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$210+ Cheap flights from Roanoke (ROA) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/22. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — JAN
Feb 15 — Feb 221
Sun 2/15
Sun 2/22
1 adult, Economy
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Cheap flight deals from Roanoke to Mississippi

Keep the following information in mind while searching for Roanoke to Mississippi flight deals. Data was last updated January 16, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$269
(Delta)

One-way from

$210
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$464
Provider with most accurate pricing for Roanoke-Jackson-Evers Intl flight deals.
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Provider most trusted by Cheapflights users for Roanoke-Jackson-Evers Intl flights.
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From Roanoke to Mississippi
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One-way flight from Roanoke to Mississippi
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Highest demand for flights based on searches. 3% potential increase in price ($12 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Roanoke to Mississippi

Cheapest flights from Roanoke to Mississippi
Explore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 16, 2026.

This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/126:00 am
ROA
-
MEM
1 stop5h 52m
Delta
Thu 2/197:13 pm
MEM
-
ROA
1 stop3h 53m
Delta
Deal found 1/15$269
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:00 pm
ROA
-
MEM
1 stop4h 51m
American Airlines
Sun 2/158:53 am
MEM
-
ROA
2 stops7h 45m
American Airlines
Deal found 1/15$274
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/305:14 pm
ROA
-
JAN
1 stop7h 31m
American Airlines
Tue 2/36:15 am
JAN
-
ROA
1 stop4h 54m
American Airlines
Deal found 1/15$279
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/296:00 am
ROA
-
MEM
1 stop5h 52m
Delta
Mon 2/26:55 pm
MEM
-
ROA
1 stop4h 09m
Delta
Deal found 1/14$279
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/293:39 pm
ROA
-
MEM
1 stop7h 20m
United Airlines
Mon 2/27:30 am
MEM
-
ROA
2 stops11h 01m
United Airlines
Deal found 1/14$284
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:00 am
ROA
-
MEM
1 stop4h 12m
American Airlines
Sun 2/1511:21 am
MEM
-
ROA
1 stop5h 17m
American Airlines
Deal found 1/13$289
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/51:56 pm
ROA
-
MEM
1 stop4h 16m
American Airlines
Mon 2/96:35 am
MEM
-
ROA
2 stops8h 35m
American Airlines
Deal found 1/13$294
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/158:00 pm
ROA
-
JAN
1 stop4h 44m
American Airlines
Sun 2/226:42 pm
JAN
-
ROA
1 stop4h 03m
American Airlines
Deal found 1/16$304
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/312:55 pm
ROA
-
MEM
2 stops7h 59m
United Airlines
Wed 2/48:00 am
MEM
-
ROA
2 stops10h 31m
United Airlines
Deal found 1/15$315
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/52:55 pm
ROA
-
MEM
2 stops8h 04m
United Airlines
Mon 2/97:30 am
MEM
-
ROA
2 stops11h 01m
United Airlines
Deal found 1/13$341
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1710:15 am
ROA
-
MEM
2 stops12h 44m
United Airlines
Mon 2/237:30 am
MEM
-
ROA
2 stops11h 37m
United Airlines
Deal found 1/14$418
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:38 pm
ROA
-
MEM
1 stop5h 15m
United Airlines
Sat 10/317:30 am
MEM
-
ROA
2 stops10h 08m
United Airlines
Deal found 1/13$433

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 16, 2026.
Use the filters below to find and compare flights from Roanoke to Mississippi that are best for you.

Fly from

Roanoke

Fly to

Mississippi

Route

Depart

Return

Price

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Thu 2/12

6:00 am-10:52 am

1 stop5h 52m

Memphis

Thu 2/19

7:13 pm-12:06 am

1 stop3h 53m

$269

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Thu 2/12

8:00 pm-11:51 pm

1 stop4h 51m

Memphis

Thu 2/19

11:04 am-5:38 pm

1 stop5h 34m

$269

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Thu 2/5

6:00 am-10:52 am

1 stop5h 52m

Memphis

Mon 2/9

5:22 pm-12:04 am

1 stop5h 42m

$269

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Fri 2/13

8:00 pm-11:51 pm

1 stop4h 51m

Memphis

Sun 2/15

5:00 am-10:37 am

1 stop4h 37m

$269

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Tue 2/17

8:15 am-5:11 pm

2 stops9h 56m

Memphis

Mon 2/23

11:04 am-5:38 pm

1 stop5h 34m

$274

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Sat 1/31

5:39 pm-9:54 pm

1 stop5h 15m

Memphis

Wed 2/4

8:00 am-2:46 pm

1 stop5h 46m

$279

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Thu 1/29

6:00 am-10:52 am

1 stop5h 52m

Memphis

Mon 2/2

6:55 pm-12:04 am

1 stop4h 09m

$279

RoanokeJackson

ROA - JAN

ROAJAN

Roanoke

Fri 1/30

5:14 pm-11:45 pm

1 stop7h 31m

Jackson-Evers Intl

Tue 2/3

6:15 am-12:09 pm

1 stop4h 54m

$279

RoanokeJackson

ROA - JAN

ROAJAN

Roanoke

Sun 2/15

8:00 pm-11:44 pm

1 stop4h 44m

Jackson-Evers Intl

Sun 2/22

6:42 pm-11:45 pm

1 stop4h 03m

$304

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Tue 2/10

2:55 pm-7:51 pm

1 stop5h 56m

Mobile

Sat 2/14

4:55 pm-2:12 pm

2 stops20h 17m

$478

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/13

Showing 1-10 of 19 results
1
2

Best time to book a flight from Roanoke to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Mississippi

What is the cheapest month to book a flight from Roanoke to Mississippi?

Currently, March is the cheapest month in which you can book a flight from Roanoke to Mississippi (average of $145). Flying from Roanoke to Mississippi in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated January 16, 2026.
Read through reviews of airlines operating flights from Roanoke to Mississippi, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,051 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,051 reviews
Delta
7.9
Good
8,051 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,136 reviews
Delta
7.9
Good
8,051 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Mississippi?

    Most people fly from Roanoke (ROA) if they book a flight from Roanoke to Mississippi. Roanoke is conveniently located just 4.2 mi from Roanoke’s city center.

  • How long is the flight from Roanoke to Mississippi?

    Delta, American Airlines, and United Airlines can get you from Roanoke to Mississippi in just under 4h 51m. Your travel time can differ by up to 1h 05m. Airlines will cover a distance of 579 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Roanoke to Mississippi?

    Most travelers choose Roanoke - Memphis, Roanoke - Mobile or Roanoke - Jackson-Evers Intl when deciding on the best route from Roanoke to Mississippi.

  • Can I find deals for flights from Roanoke to Mississippi that include hotel bookings?

    Yes. In addition to deals on Roanoke to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Mississippi.

  • Can I find deals for business class flights from Roanoke to Mississippi?

    Yes. Cheapflights offers flight deals from Roanoke to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Mississippi?

    Currently, March is the cheapest month in which you can book a flight from Roanoke to Mississippi (average of $145). Flying from Roanoke to Mississippi in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Roanoke to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Roanoke to Mississippi

Discover the top 2 airlines that operate flights from Roanoke to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$371FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$318FlexibilityNo cancel feeOn-timeN/A

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