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$239+ Cheap flights from Roanoke (ROA) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — JAN
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
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Cheap flight deals from Roanoke to Mississippi

Keep the following information in mind while searching for Roanoke to Mississippi flight deals. Data was last updated August 18, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$239
(Delta)

Popular in

December

Cheapest in

August

Average price

$248
From Roanoke to Mississippi
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One-way flight from Roanoke to Mississippi
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Highest demand for flights based on searches. 26% potential increase in price ($158 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Roanoke to Mississippi

Cheapest flights from Roanoke to Mississippi
Explore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/185:00 amROA - MEM
1 stop4h 18mAmerican Airlines
Sun 9/215:04 amMEM - ROA
1 stop4h 43mAmerican Airlines
Deal found 8/16$249
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/147:59 pmROA - MOB
1 stop3h 49mDelta
Mon 10/206:59 pmMOB - ROA
1 stop4h 10mDelta
Deal found 8/17$249
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/27:51 pmROA - JAN
1 stop4h 29mDelta
Sat 9/66:50 pmJAN - ROA
1 stop4h 42mDelta
Deal found 8/17$259
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:00 amROA - MEM
1 stop3h 31mDelta
Sun 10/196:06 pmMEM - ROA
1 stop5h 03mDelta
Deal found 8/16$279
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:00 amROA - MOB
1 stop3h 33mDelta
Tue 10/216:59 pmMOB - ROA
1 stop4h 10mDelta
Deal found 8/17$279
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:00 amROA - MOB
1 stop3h 33mDelta
Sat 10/189:13 amMOB - ROA
1 stop4h 49mDelta
Deal found 8/17$309
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1810:50 amROA - MEM
1 stop7h 49mUnited Airlines
Sun 9/212:50 pmMEM - ROA
2 stops7h 34mUnited Airlines
Deal found 8/16$324
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:27 pmROA - MOB
1 stop4h 30mAmerican Airlines
Wed 10/226:40 amMOB - ROA
2 stops9h 49mAmerican Airlines
Deal found 8/16$327
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/147:59 pmROA - MOB
1 stop3h 49mDelta
Tue 10/215:43 amMOB - ROA
2 stops16h 02mDelta
Deal found 8/17$353
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:00 amROA - MOB
1 stop3h 33mDelta
Wed 10/226:59 pmMOB - ROA
1 stop4h 10mDelta
Deal found 8/17$363
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:00 amROA - MOB
1 stop3h 33mDelta
Thu 10/236:59 pmMOB - ROA
1 stop4h 10mDelta
Deal found 8/17$393
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/147:05 amROA - MOB
2 stops16h 43mDelta
Fri 10/246:59 pmMOB - ROA
1 stop4h 10mDelta
Deal found 8/17$408

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Roanoke to Mississippi that are best for you.

Fly from

Roanoke

Fly to

Mississippi

Route

Depart

Return

Price

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Thu 9/18

5:00 am-8:18 am

1 stop4h 18m

Memphis

Sun 9/21

5:04 am-10:47 am

1 stop4h 43m

$249

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 10/18

7:59 pm-10:48 pm

1 stop3h 49m

Mobile

Tue 10/21

6:59 pm-12:09 am

1 stop4h 10m

$249

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Tue 10/14

7:59 pm-10:48 pm

1 stop3h 49m

Mobile

Wed 10/22

6:59 pm-12:09 am

1 stop4h 10m

$249

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Tue 10/14

7:59 pm-10:48 pm

1 stop3h 49m

Mobile

Mon 10/20

6:59 pm-12:09 am

1 stop4h 10m

$249

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 10/18

6:00 am-8:25 am

1 stop3h 25m

Mobile

Fri 10/24

6:59 pm-12:09 am

1 stop4h 10m

$249

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 10/18

6:00 am-8:25 am

1 stop3h 25m

Mobile

Wed 10/22

6:59 pm-12:09 am

1 stop4h 10m

$249

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 10/18

6:00 am-8:25 am

1 stop3h 25m

Mobile

Mon 10/20

6:59 pm-12:09 am

1 stop4h 10m

$249

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Tue 10/14

7:59 pm-10:48 pm

1 stop3h 49m

Mobile

Tue 10/21

6:59 pm-12:09 am

1 stop4h 10m

$249

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Tue 10/14

7:59 pm-10:48 pm

1 stop3h 49m

Mobile

Fri 10/24

6:59 pm-12:09 am

1 stop4h 10m

$249

RoanokeJackson

ROA - JAN

ROAJAN

Roanoke

Tue 9/2

7:51 pm-11:20 pm

1 stop4h 29m

Jackson-Evers Intl

Sat 9/6

6:50 pm-12:32 am

1 stop4h 42m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/16

Showing 1-10 of 29 results
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Best time to book a flight from Roanoke to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Mississippi

What is the cheapest month to book a flight from Roanoke to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Roanoke to Mississippi (average of $371). Flying from Roanoke to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to MS?

Find hourly flight availability from Roanoke to Mississippi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 18, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Roanoke to Mississippi as you normally would.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated August 18, 2025.
Read through reviews of airlines operating flights from Roanoke to Mississippi, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Mississippi?

    Most people fly from Roanoke (ROA) if they book a flight from Roanoke to Mississippi. Roanoke is conveniently located just 4.2 mi from Roanoke’s city center.

  • What are the most popular routes from Roanoke to Mississippi?

    Most travelers choose Roanoke - Memphis, Roanoke - Mobile or Roanoke - Jackson-Evers Intl when deciding on the best route from Roanoke to Mississippi.

  • Can I find deals for flights from Roanoke to Mississippi that include hotel bookings?

    Yes. In addition to deals on Roanoke to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Mississippi.

  • Can I find deals for business class flights from Roanoke to Mississippi?

    Yes. Cheapflights offers flight deals from Roanoke to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Roanoke to Mississippi (average of $371). Flying from Roanoke to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Roanoke to Mississippi

Discover the top 2 airlines that operate flights from Roanoke to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$353FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$340FlexibilityNo cancel feeOn-timeN/A

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