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$249+ Cheap flights from Roanoke (ROA) to Mississippi

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — JAN
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
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Find flight deals from Roanoke to Mississippi

Cheapest flights from Roanoke to Mississippi
Explore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:45 amROA - MEM
1 stop5h 13mUnited Airlines
Sat 11/1510:30 amMEM - ROA
1 stop5h 26mUnited Airlines
Deal found 10/12$249
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/285:38 pmROA - MEM
1 stop5h 20mUnited Airlines
Sat 11/110:30 amMEM - ROA
1 stop5h 26mUnited Airlines
Deal found 10/13$259
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:40 pmROA - MEM
1 stop5h 08mUnited Airlines
Wed 10/297:30 amMEM - ROA
2 stops10h 13mUnited Airlines
Deal found 10/13$314
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:38 pmROA - MEM
1 stop5h 21mUnited Airlines
Sat 11/152:55 pmMEM - ROA
1 stop5h 13mUnited Airlines
Deal found 10/13$319
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:18 pmROA - JAN
1 stop4h 54mAmerican Airlines
Sat 10/187:08 amJAN - ROA
1 stop6h 32mAmerican Airlines
Deal found 10/11$324
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:45 amROA - MOB
2 stops8h 37mUnited Airlines
Sat 11/17:00 amMOB - ROA
2 stops8h 56mUnited Airlines
Deal found 10/13$339
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/193:29 pmROA - MEM
1 stop6h 24mAmerican Airlines
Sun 11/237:02 amMEM - ROA
1 stop6h 18mAmerican Airlines
Deal found 10/13$362

Cheap flight deals from Roanoke to Mississippi

Keep the following information in mind while searching for Roanoke to Mississippi flight deals. Data was last updated October 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Delta)

Popular in

December

Cheapest in

August

Average price

$668
Provider with most accurate pricing for Roanoke-Jackson-Evers Intl flight deals.
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Provider most trusted by Cheapflights users for Roanoke-Jackson-Evers Intl flights.
Search Deals
From Roanoke to Mississippi
Search Deals
Highest demand for flights based on searches. 32% potential increase in price ($202 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Roanoke to Mississippi that are best for you.

Fly from

Roanoke

Fly to

Mississippi

Route

Depart

Return

Price

RoanokeJackson

ROA - JAN

ROAJAN

Roanoke

Sat 2/21

7:50 pm-11:23 pm

1 stop4h 33m

Jackson-Evers Intl

Tue 2/24

7:45 am-2:39 pm

1 stop5h 54m

$249

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Sat 11/8

6:45 am-10:58 am

1 stop5h 13m

Memphis

Sat 11/15

10:30 am-4:56 pm

1 stop5h 26m

$249

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 2/21

7:50 pm-10:59 pm

1 stop4h 09m

Mobile

Tue 2/24

5:55 am-10:33 am

1 stop3h 38m

$249

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Tue 10/28

6:20 am-3:33 pm

2 stops10h 13m

Memphis

Sat 11/1

2:55 pm-11:30 pm

2 stops7h 35m

$269

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Fri 10/24

5:40 pm-9:48 pm

1 stop5h 08m

Memphis

Wed 10/29

7:30 am-6:43 pm

2 stops10h 13m

$314

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Wed 11/12

6:45 am-10:56 am

1 stop5h 11m

Memphis

Sat 11/15

2:55 pm-9:08 pm

1 stop5h 13m

$319

RoanokeJackson

ROA - JAN

ROAJAN

Roanoke

Sat 2/21

8:30 am-3:40 pm

2 stops8h 10m

Jackson-Evers Intl

Tue 2/24

6:47 pm-11:41 pm

1 stop3h 54m

$324

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 2/21

4:06 pm-9:32 pm

1 stop6h 26m

Mobile

Tue 2/24

5:22 am-4:25 pm

2 stops10h 03m

$324

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Sat 2/21

6:00 am-10:56 am

1 stop5h 56m

Memphis

Wed 2/25

5:10 pm-11:49 pm

1 stop5h 39m

$352

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Tue 10/28

7:50 pm-8:12 pm

1 stop25h 22m

Mobile

Sat 11/1

7:00 am-4:56 pm

2 stops8h 56m

$438

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/11

Best time to book a flight from Roanoke to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Mississippi

What is the cheapest month to book a flight from Roanoke to Mississippi?

Currently, March is the cheapest month in which you can book a flight from Roanoke to Mississippi (average of $145). Flying from Roanoke to Mississippi in October is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated October 14, 2025.
Read through reviews of airlines operating flights from Roanoke to Mississippi, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,045 reviews
Delta
8.0
Very good
7,973 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Mississippi?

    Most people fly from Roanoke (ROA) if they book a flight from Roanoke to Mississippi. Roanoke is conveniently located just 4.2 mi from Roanoke’s city center.

  • How long is the flight from Roanoke to Mississippi?

    Delta, United Airlines, and American Airlines can get you from Roanoke to Mississippi in just under 4h 33m. Your travel time can differ by up to 3h 37m. Airlines will cover a distance of 669 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Roanoke to Mississippi?

    Most travelers choose Roanoke - Memphis, Roanoke - Jackson-Evers Intl or Roanoke - Mobile when deciding on the best route from Roanoke to Mississippi.

  • Can I find deals for flights from Roanoke to Mississippi that include hotel bookings?

    Yes. In addition to deals on Roanoke to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Mississippi.

  • Can I find deals for business class flights from Roanoke to Mississippi?

    Yes. Cheapflights offers flight deals from Roanoke to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Mississippi?

    Currently, March is the cheapest month in which you can book a flight from Roanoke to Mississippi (average of $145). Flying from Roanoke to Mississippi in October is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Roanoke to Mississippi

Discover the top 2 airlines that operate flights from Roanoke to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$353FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$366FlexibilityNo cancel feeOn-timeN/A

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