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$264+ Cheap flights from Roanoke (ROA) to Mississippi

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — JAN
Dec 31 — Jan 71
Wed 12/31
Wed 1/7
1 adult, Economy
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Find flight deals from Roanoke to Mississippi

Cheapest flights from Roanoke to Mississippi
Explore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 1, 2025.

This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:07 pmROA - MEM
1 stop5h 49mAmerican Airlines
Wed 12/315:00 amMEM - ROA
1 stop4h 31mAmerican Airlines
Deal found 11/29$294
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:03 pmROA - MEM
1 stop4h 52mAmerican Airlines
Fri 12/128:49 amMEM - ROA
1 stop6h 49mAmerican Airlines
Deal found 11/28$309
This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:31 pmROA - MEM
1 stop4h 22mAmerican Airlines
Mon 12/1510:29 amMEM - ROA
2 stops9h 01mAmerican Airlines
Deal found 11/29$314
This United Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:40 pmROA - MEM
1 stop5h 19mUnited Airlines
Sat 12/63:01 pmMEM - ROA
1 stop4h 44mUnited Airlines
Deal found 11/28$339
This Delta deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amROA - MEM
1 stop6h 42mDelta
Sun 12/77:21 pmMEM - ROA
1 stop3h 50mDelta
Deal found 11/30$354
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:54 pmROA - MEM
2 stops8h 10mAmerican Airlines
Sun 12/75:05 amMEM - ROA
1 stop4h 29mAmerican Airlines
Deal found 12/1$374
This United Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:45 amROA - MEM
1 stop5h 11mUnited Airlines
Sun 12/147:39 amMEM - ROA
2 stops10h 17mUnited Airlines
Deal found 11/29$384
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1510:50 amROA - MOB
2 stops11h 57mUnited Airlines
Fri 12/1912:59 pmMOB - ROA
1 stop24h 17mUnited Airlines
Deal found 11/30$617
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/29:01 amROA - JAN
1 stop5h 19mAmerican Airlines
Fri 12/51:46 pmJAN - ROA
1 stop17h 48mAmerican Airlines
Deal found 12/1$821

Cheap flight deals from Roanoke to Mississippi

Keep the following information in mind while searching for Roanoke to Mississippi flight deals. Data was last updated December 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(American Airlines)

Popular in

June

Cheapest in

August

Average price

$491
Provider with most accurate pricing for Roanoke-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Roanoke-Jackson-Evers Intl flights.
Search Deals
From Roanoke to Mississippi
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($6 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 1, 2025.
Use the filters below to find and compare flights from Roanoke to Mississippi that are best for you.

Fly from

Roanoke

Fly to

Mississippi

Route

Depart

Return

Price

RoanokeJackson

ROA - JAN

ROAJAN

Roanoke

Sat 2/7

11:24 am-2:06 pm

1 stop3h 42m

Jackson-Evers Intl

Wed 2/11

4:58 pm-11:49 pm

1 stop5h 51m

$264

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Tue 1/20

11:24 am-4:16 pm

1 stop5h 52m

Memphis

Sat 1/24

5:22 pm-12:04 am

1 stop5h 42m

$264

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 1/24

6:00 am-11:45 am

1 stop6h 45m

Mobile

Tue 1/27

9:10 am-3:07 pm

1 stop4h 57m

$293

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Wed 4/15

6:00 am-8:30 am

1 stop3h 30m

Mobile

Sat 4/18

5:00 pm-11:49 pm

1 stop5h 49m

$293

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 1/24

6:00 am-11:45 am

1 stop6h 45m

Mobile

Wed 1/28

6:00 am-10:39 am

1 stop3h 39m

$293

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Fri 12/26

7:07 pm-11:56 pm

1 stop5h 49m

Memphis

Wed 12/31

5:00 am-10:31 am

1 stop4h 31m

$294

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Fri 12/5

5:03 pm-8:55 pm

1 stop4h 52m

Memphis

Fri 12/12

8:49 am-4:38 pm

1 stop6h 49m

$309

RoanokeMemphis

ROA - MEM

ROAMEM

Roanoke

Fri 12/12

6:00 am-9:27 am

1 stop4h 27m

Memphis

Mon 12/15

7:21 pm-12:11 am

1 stop3h 50m

$309

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 1/24

8:00 am-4:59 pm

2 stops9h 59m

Mobile

Wed 1/28

11:14 am-6:58 pm

1 stop6h 44m

$324

RoanokeMobile

ROA - MOB

ROAMOB

Roanoke

Sat 1/24

8:00 am-4:59 pm

2 stops9h 59m

Mobile

Tue 1/27

11:14 am-6:58 pm

1 stop6h 44m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/30

Showing 1-10 of 17 results
1
2

Best time to book a flight from Roanoke to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Mississippi

What is the cheapest month to book a flight from Roanoke to Mississippi?

Currently, March is the cheapest month in which you can book a flight from Roanoke to Mississippi (average of $145). Flying from Roanoke to Mississippi in September is currently the most expensive (average of $319). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated December 1, 2025.
Read through reviews of airlines operating flights from Roanoke to Mississippi, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,010 reviews

Comfort

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,010 reviews
Delta
7.9
Good
8,010 reviews

Comfort

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,041 reviews
Delta
7.9
Good
8,010 reviews

Comfort

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Mississippi?

    Most people fly from Roanoke (ROA) if they book a flight from Roanoke to Mississippi. Roanoke is conveniently located just 4.2 mi from Roanoke’s city center.

  • How long is the flight from Roanoke to Mississippi?

    Delta and American Airlines can get you from Roanoke to Mississippi in just under 3h 42m. Your travel time can differ by up to 2h 07m. Airlines will cover a distance of 669 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Roanoke to Mississippi?

    Most travelers choose Roanoke - Memphis, Roanoke - Mobile or Roanoke - Jackson-Evers Intl when deciding on the best route from Roanoke to Mississippi.

  • Can I find deals for flights from Roanoke to Mississippi that include hotel bookings?

    Yes. In addition to deals on Roanoke to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Mississippi.

  • Can I find deals for business class flights from Roanoke to Mississippi?

    Yes. Cheapflights offers flight deals from Roanoke to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Mississippi?

    Currently, March is the cheapest month in which you can book a flight from Roanoke to Mississippi (average of $145). Flying from Roanoke to Mississippi in September is currently the most expensive (average of $319). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Roanoke to Mississippi

Discover the top 2 airlines that operate flights from Roanoke to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$371FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$308FlexibilityNo cancel feeOn-timeN/A

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