HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Mexico City

$180+ Cheap flights from Panama City (PTY) to Mexico City (MEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Mexico City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Mexico City Benito Juarez are usually found in July or August, booked 69 days in advance, depart on a Tuesday or Thursday and return on a Wednesday

Cheap flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$336
(Priceline)

One-way from

$180
(Cheapflightsfares)

Popular in

October

Cheapest in

July

Average price

$424

Good round-trip deal

$343 or less

Good one-way deal

$225 or less
From Panama City Tocumen Intl to Mexico City Benito Juarez
Search Deals
One-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($20 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($3 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Mexico City Benito Juarez.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez.
Search Deals

Find flight deals from Panama City to Mexico City

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Priceline deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/243:20 amPTY - MEX
1 stop15h 45mAvianca
Wed 10/112:40 amMEX - PTY
1 stop14h 50mAvianca
Deal found 9/9$336
This Cheapflightsfares deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/189:45 amPTY - MEX
1 stop14h 10mAvianca
Sun 11/2312:40 amMEX - PTY
1 stop12h 20mAvianca
Deal found 9/9$340
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2710:21 pmPTY - MEX
Nonstop3h 39mCopa Airlines
Sat 10/43:30 pmMEX - PTY
Nonstop3h 43mCopa Airlines
Deal found 9/10$343
This Aeromexico deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/232:44 pmPTY - MEX
Nonstop3h 56mAeromexico
Wed 10/158:45 amMEX - PTY
Nonstop3h 57mAeromexico
Deal found 9/10$344
This Avianca deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/52:55 amPTY - MEX
1 stop16h 15mAvianca
Sun 11/94:00 amMEX - PTY
1 stop5h 20mAvianca
Deal found 9/9$345
This Priceline deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/58:10 pmPTY - MEX
1 stop15h 45mAvianca
Fri 10/1012:40 amMEX - PTY
1 stop14h 50mAvianca
Deal found 9/8$347
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/197:50 pmPTY - MEX
1 stop6h 25mAvianca
Sat 11/2911:15 pmMEX - PTY
1 stop8h 35mAvianca
Deal found 9/9$351
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:25 pmPTY - MEX
1 stop10h 40mAvianca
Mon 11/104:00 amMEX - PTY
1 stop5h 20mAvianca
Deal found 9/8$354
This Avianca deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/68:10 pmPTY - MEX
1 stop15h 45mAvianca
Mon 10/2012:40 amMEX - PTY
1 stop7h 15mAvianca
Deal found 9/9$356
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:25 pmPTY - MEX
1 stop10h 40mAvianca
Wed 11/1212:55 pmMEX - PTY
1 stop5h 30mAvianca
Deal found 9/8$360
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2511:46 amPTY - MEX
Nonstop3h 44mCopa Airlines
Mon 9/299:50 amMEX - PTY
Nonstop3h 49mCopa Airlines
Deal found 9/11$365

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Panama City

Fly to

Mexico City

Route

Depart

Return

Price

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Mon 10/6

9:26 am-12:10 pm

Nonstop3h 44m

Mexico City Benito Juarez

Tue 10/21

9:50 am-2:39 pm

Nonstop3h 49m

$343

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 10/10

11:50 am-2:30 pm

Nonstop3h 40m

Mexico City Benito Juarez

Fri 10/17

3:30 pm-8:13 pm

Nonstop3h 43m

$343

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 9/27

10:21 pm-1:00 am

Nonstop3h 39m

Mexico City Benito Juarez

Sat 10/4

3:30 pm-8:13 pm

Nonstop3h 43m

$343

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 10/4

10:21 pm-1:00 am

Nonstop3h 39m

Mexico City Benito Juarez

Wed 10/15

1:05 pm-5:50 pm

Nonstop3h 45m

$343

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 9/19

9:21 am-12:10 pm

Nonstop3h 49m

Mexico City Benito Juarez

Sun 10/5

1:05 pm-5:50 pm

Nonstop3h 45m

$343

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 9/17

10:21 pm-1:00 am

Nonstop3h 39m

Mexico City Benito Juarez

Mon 9/22

1:05 pm-5:49 pm

Nonstop3h 44m

$365

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 11/20

10:03 pm-1:00 am

Nonstop3h 57m

Mexico City Benito Juarez

Tue 11/25

3:30 pm-8:14 pm

Nonstop3h 44m

$365

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 10/10

9:26 am-12:10 pm

Nonstop3h 44m

Mexico City Benito Juarez

Thu 10/16

1:05 pm-5:50 pm

Nonstop3h 45m

$365

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sun 10/5

9:26 am-12:10 pm

Nonstop3h 44m

Mexico City Benito Juarez

Sat 10/11

1:05 pm-5:50 pm

Nonstop3h 45m

$365

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 9/19

9:21 am-12:10 pm

Nonstop3h 49m

Mexico City Benito Juarez

Sun 9/21

9:50 am-2:39 pm

Nonstop3h 49m

$365

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 19 results
1
2

The best insider tips for Panama City to Mexico City flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Mexico City trip
Airports
PTY

For a smooth departure, use authorized taxis or Uber from PTY to Panama City. Confirm taxi rates before leaving the airport.

Read more about PTYby Taryn White
MEX

For a quick arrival at MEX, consider using Uber. It's cheaper and more reliable than taxis for reaching downtown Mexico City.

Read more about MEXby Brandon Schultz
Our travel experts
Brandon Schultz

Brandon Schultz

Expert on MEX

Brandon Schultz

Brandon Schultz

Brandon Schultz is an award-winning food and travel writer based in New York City. His work has appeared in Forbes, AAA, Thrillist, Travel + Leisure, and The Daily Meal, among many others, and he is the author of 6 books, including 3 cookbooks.

Read more
Taryn White

Taryn White

Expert on PTY

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Mexico City. Price data was last updated on August 29, 2025.

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, May is the cheapest month in which you can book a flight from Panama City to Mexico City (average of $387). Flying from Panama City to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s typically best to fly out from Panama City to Mexico City in the morning. Doing so could potentially save you 35% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Panama City to Mexico City?

Use this chart to determine the cheapest time to fly round-trip from Panama City to Mexico City. Price data was last updated on September 7, 2025.

Travelers seeking maximum savings on their Panama City to Mexico City flight should consider departing on Friday at noon when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated September 11, 2025.
See what other customers who have flown with Copa Airlines, Aeromexico, and Avianca from Panama City to Mexico City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Aeromexico
7.5
Good
1,701 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Mexico City?

    Booking a flight from Panama City Tocumen Intl (PTY) to Mexico City Benito Juarez (MEX) is your only option if you wish to fly from Panama City to Mexico City. On a typical day, there are 8 flights from Tocumen Intl to Benito Juarez, all of which are around 3h 38m for a nonstop flight. You can also purchase a plane ticket from 3 airlines when you book a flight from Tocumen Intl to Mexico City.

  • How popular is this Panama City to Mexico City flight route?

    The Panama City Tocumen Intl to Mexico City Benito Juarez flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Mexico City?

    There are many flights that can get you from Panama City to Mexico City in 3h 44m. Fly via Copa Airlines to get the fastest option. There are 1497 mi between Panama City and Mexico City. All flights are typically nonstop.

  • What are the cheapest airlines flying from Panama City to Mexico City round-trip?

    Cheapflights users have booked flights from Panama City to Mexico City round-trip from $212. Other airlines that can offer you cheap pricing are Avianca, from $306, and Copa Airlines, from $340. Aeromexico is 48% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Panama City to Mexico City?

    The top 3 most reliable airlines when flying from Panama City to Mexico City are AeroMexico Connect (100%), Emirates (96%) and Copa Airlines (90%).

  • What are the cheapest flights from Panama City to Mexico City?

    Looking for the cheapest flight from Panama City to Mexico City? While on average our users pay $442, our data indicates the cheapest price to be $192. The most popular route (Panama City Tocumen Intl - Mexico City Benito Juarez), is priced around $332.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, May is the cheapest month in which you can book a flight from Panama City to Mexico City (average of $387). Flying from Panama City to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Panama City to Mexico City

Discover the top 3 airlines that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$212Average$344FlexibilityNo cancel feeOn-timeN/A
AviancaCheapest$306Average$428FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$340Average$440FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.