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$189+ Cheap flights from Panama City (PTY) to Mexico City (MEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Mexico City Benito Juarez are usually found in July or June, booked 69 days in advance, depart on a Tuesday or Thursday and return on a Wednesday

Cheap flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2025.

Round-trip from

$313
(Priceline)

One-way from

$189
(Avianca)

Popular in

October

Cheapest in

July

Average price

$349

Good round-trip deal

$342 or less

Good one-way deal

$404 or less
From Panama City Tocumen Intl to Mexico City Benito Juarez
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One-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez
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Highest demand for flights based on searches. 5% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Mexico City Benito Juarez.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez.
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Find flight deals from Panama City to Mexico City

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This Priceline deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1710:05 pmPTY - MEX
1 stop21h 00mAvianca
Mon 9/225:00 amMEX - PTY
1 stop8h 40mAvianca
Deal found 7/28$313
This SmartFares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/52:44 pmPTY - MEX
Nonstop3h 56mAeromexico
Fri 9/198:50 amMEX - PTY
Nonstop3h 49mAeromexico
Deal found 7/29$322
This Copa Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/159:21 amPTY - MEX
Nonstop3h 49mCopa Airlines
Mon 9/222:00 amMEX - PTY
Nonstop3h 44mCopa Airlines
Deal found 7/29$342
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1110:05 pmPTY - MEX
2 stops24h 40mMultiple Airlines
Mon 8/184:50 pmMEX - PTY
1 stop16h 35mMultiple Airlines
Deal found 7/28$416

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Panama City

Fly to

Mexico City

Route

Depart

Return

Price

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 9/17

10:05 pm-6:05 pm

1 stop21h 00m

Mexico City Benito Juarez

Mon 9/22

5:00 am-2:40 pm

1 stop8h 40m

$313

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 9/5

2:44 pm-5:40 pm

Nonstop3h 56m

Mexico City Benito Juarez

Fri 9/19

8:50 am-1:39 pm

Nonstop3h 49m

$322

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Mon 9/15

9:21 am-12:10 pm

Nonstop3h 49m

Mexico City Benito Juarez

Mon 9/22

2:00 am-6:44 am

Nonstop3h 44m

$342

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Mon 8/11

10:05 pm-9:45 pm

2 stops24h 40m

Mexico City Benito Juarez

Mon 8/18

4:50 pm-10:25 am

1 stop16h 35m

$416

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 8/15

3:40 pm-10:55 am

1 stop20h 15m

$189

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 8/15

10:05 pm-7:45 pm

2 stops22h 40m

$281

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 8/15

9:32 pm-12:15 am

Nonstop3h 43m

$399

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sun 9/21

9:22 am-8:35 am

3 stops24h 13m

$1,942

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

The best insider tips for Panama City to Mexico City flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Mexico City trip
Airports
PTY

For a smooth departure, use authorized taxis or Uber from PTY to Panama City. Confirm taxi rates before leaving the airport.

Read more about PTYby Taryn White
MEX

For a quick arrival at MEX, consider using Uber. It's cheaper and more reliable than taxis for reaching downtown Mexico City.

Read more about MEXby Brandon Schultz
Our travel experts
Brandon Schultz

Brandon Schultz

Expert on MEX

Brandon Schultz

Brandon Schultz

Brandon Schultz is an award-winning food and travel writer based in New York City. His work has appeared in Forbes, AAA, Thrillist, Travel + Leisure, and The Daily Meal, among many others, and he is the author of 6 books, including 3 cookbooks.

Read more
Taryn White

Taryn White

Expert on PTY

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Mexico City. Price data was last updated on July 25, 2025.

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, May is the cheapest month in which you can book a flight from Panama City to Mexico City (average of $388). Flying from Panama City to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

It’s typically best to fly out from Panama City to Mexico City in the evening. Doing so could potentially save you 62% on the flight price compared to flying at noon, which is usually more expensive.

Weekly flight availability from Panama City to Mexico City

Explore weekly flight availability from Panama City to Mexico City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 30, 2025.

The most flights from PTY to MEX are scheduled on a Wednesday (8 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (1 on average).

How much does it cost to fly round-trip from Panama City to Mexico City?

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated July 30, 2025.
See what other customers who have flown with Copa Airlines, Aeromexico, and United Airlines from Panama City to Mexico City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,493 reviews

Boarding

7.8

Crew

8.1

Food

6.8

Overall

7.5

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,493 reviews
Copa Airlines
7.5
Good
1,493 reviews

Boarding

7.8

Crew

8.1

Food

6.8

Overall

7.5

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Aeromexico
7.5
Good
1,721 reviews
Copa Airlines
7.5
Good
1,493 reviews

Boarding

7.8

Crew

8.1

Food

6.8

Overall

7.5

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
United Airlines
7.4
Good
8,896 reviews
Copa Airlines
7.5
Good
1,493 reviews

Boarding

7.8

Crew

8.1

Food

6.8

Overall

7.5

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Avianca
6.7
Okay
2,387 reviews
Copa Airlines
7.5
Good
1,493 reviews

Boarding

7.8

Crew

8.1

Food

6.8

Overall

7.5

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Mexico City?

    Booking a flight from Panama City Tocumen Intl (PTY) to Mexico City Benito Juarez (MEX) is your only option if you wish to fly from Panama City to Mexico City. On a typical day, there are 4 flights from Tocumen Intl to Benito Juarez, all of which are around 3h 42m for a nonstop flight. You can also purchase a plane ticket from 3 airlines when you book a flight from Tocumen Intl to Mexico City.

  • How popular is this Panama City to Mexico City flight route?

    The Panama City Tocumen Intl to Mexico City Benito Juarez flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Panama City to Mexico City round-trip?

    Cheapflights users have booked flights from Panama City to Mexico City round-trip from $313. Other airlines that can offer you cheap pricing are Aeromexico, from $322, and Copa Airlines, from $342. Avianca is 25% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City to Mexico City one-way?

    The cheapest airline one-way is Avianca, with whom users have recently found tickets for as low as $189. However, be on the lookout for offers from Copa Airlines and United Airlines, as they are both options that can get you from Panama City to Mexico City for a low price.

  • What are the most reliable airlines from Panama City to Mexico City?

    The top 3 most reliable airlines when flying from Panama City to Mexico City are Emirates (90%), Copa Airlines (89%) and Aeromexico (61%).

  • What are the cheapest flights from Panama City to Mexico City?

    Looking for the cheapest flight from Panama City to Mexico City? While on average our users pay $496, our data indicates the cheapest price to be $321. The most popular route (Panama City Tocumen Intl - Mexico City Benito Juarez), is priced around $329.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, May is the cheapest month in which you can book a flight from Panama City to Mexico City (average of $388). Flying from Panama City to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Panama City to Mexico City

Discover the top 3 airlines that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$227Average$334FlexibilityNo cancel feeOn-timeN/A
AviancaCheapest$321Average$425FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$340Average$464FlexibilityNo cancel feeOn-time70%

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