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Mexico City

$226+ Cheap flights from Panama City (PTY) to Mexico City (MEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
feb. 28 — mar. 71
sáb. 2/28
sáb. 3/7
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Mexico City Benito Juarez are usually found in July or December, booked 75 days in advance, depart on a Thursday or Friday and return on a Wednesday

Cheap flight deals from Panama City to Mexico City

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.

This Gotogate deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/23:10 pm
PTY
-
MEX
1 stop12h 55m
Avianca
jue. 4/911:20 pm
MEX
-
PTY
1 stop13h 55m
Avianca
Deal found 1/28$315
This Gotogate deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/159:45 am
PTY
-
MEX
1 stop14h 10m
Avianca
jue. 3/1911:10 pm
MEX
-
PTY
1 stop13h 50m
Avianca
Deal found 1/29$316
This Priceline deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/249:45 am
PTY
-
MEX
1 stop18h 15m
Avianca
sáb. 2/285:00 am
MEX
-
PTY
1 stop10h 55m
Avianca
Deal found 1/29$322
This Avianca deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/137:50 pm
PTY
-
MEX
1 stop6h 25m
Avianca
vie. 2/2011:10 pm
MEX
-
PTY
1 stop13h 50m
Avianca
Deal found 1/28$324
This Avianca deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/145:55 pm
PTY
-
MEX
1 stop10h 10m
Avianca
dom. 4/194:55 pm
MEX
-
PTY
1 stop8h 00m
Avianca
Deal found 1/28$325
This SmartFares deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/152:48 pm
PTY
-
MEX
Nonstop3h 57m
Aeromexico
dom. 3/228:55 am
MEX
-
PTY
Nonstop3h 50m
Aeromexico
Deal found 1/28$333
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/152:55 pm
PTY
-
MEX
1 stop9h 00m
Avianca
dom. 2/225:00 am
MEX
-
PTY
1 stop8h 00m
Avianca
Deal found 1/28$337
This Avianca deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/147:50 pm
PTY
-
MEX
1 stop16h 30m
Avianca
lun. 2/1612:40 am
MEX
-
PTY
1 stop12h 20m
Avianca
Deal found 1/28$341
This Copa Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/1011:41 am
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
vie. 3/209:25 am
MEX
-
PTY
Nonstop3h 39m
Copa Airlines
Deal found 1/28$352
This FlightHub deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/172:55 pm
PTY
-
MEX
1 stop9h 00m
Avianca
lun. 2/235:00 am
MEX
-
PTY
1 stop8h 00m
Avianca
Deal found 1/28$353
This Avianca deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/242:55 pm
PTY
-
MEX
1 stop9h 00m
Avianca
dom. 4/124:55 am
MEX
-
PTY
1 stop8h 20m
Avianca
Deal found 1/28$365
This Copa Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 1/319:21 am
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
sáb. 2/73:30 pm
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 1/28$374

Find flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$315
(Gotogate)

One-way from

$226
(Kiwi.com)

Popular in

June

Cheapest in

July

Average price

$367

Good round-trip deal

$352 or less

Good one-way deal

$373 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Mexico City Benito Juarez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Mexico City Benito Juarez flights.
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From Panama City Tocumen Intl to Mexico City Benito Juarez
Search Deals
One-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Mexico City Benito Juarez.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Panama City

Fly to

Mexico City

Route

Depart

Return

Price

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

vie. 3/13

2:55 pm-10:55 pm

1 stop9h 00m

Mexico City Benito Juarez

lun. 3/16

12:40 am-2:00 pm

1 stop12h 20m

$322

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

mar. 2/10

9:45 am-6:10 pm

1 stop9h 25m

Mexico City Benito Juarez

jue. 2/12

12:40 am-4:55 pm

1 stop15h 15m

$322

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

mié. 2/18

9:45 am-6:10 pm

1 stop9h 25m

Mexico City Benito Juarez

sáb. 2/21

5:00 am-2:00 pm

1 stop8h 00m

$337

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

jue. 4/2

9:19 am-12:10 pm

Nonstop3h 51m

Mexico City Benito Juarez

jue. 4/9

3:30 pm-8:10 pm

Nonstop3h 40m

$352

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

mar. 3/10

11:41 am-2:30 pm

Nonstop3h 49m

Mexico City Benito Juarez

vie. 3/20

9:25 am-2:04 pm

Nonstop3h 39m

$352

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

dom. 3/1

4:23 pm-7:20 pm

Nonstop3h 57m

Mexico City Benito Juarez

mar. 3/17

9:25 am-2:04 pm

Nonstop3h 39m

$352

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

mié. 2/18

11:45 am-2:30 pm

Nonstop3h 45m

Mexico City Benito Juarez

mar. 2/24

1:20 am-6:00 am

Nonstop3h 40m

$352

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

sáb. 2/14

7:02 pm-10:05 pm

Nonstop4h 03m

Mexico City Benito Juarez

sáb. 2/21

1:10 pm-5:48 pm

Nonstop3h 38m

$352

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

mié. 2/25

9:25 pm-12:15 am

Nonstop3h 50m

Mexico City Benito Juarez

mar. 3/3

1:20 am-5:54 am

Nonstop3h 34m

$352

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

mar. 3/10

9:22 am-12:10 pm

Nonstop3h 48m

Mexico City Benito Juarez

mar. 3/17

3:30 pm-8:13 pm

Nonstop3h 43m

$352

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 21 results
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  • Most accurate provider: When it comes to deals on Panama City-Mexico City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Mexico City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Mexico City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Mexico City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Mexico City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Mexico City. Price data was last updated on January 23, 2026.

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 75 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of $171). Flying from Panama City to Mexico City in March is currently the most expensive (average of $322). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated enero 29, 2026.

It’s typically best to fly out from Panama City to Mexico City at noon. Doing so could potentially save you 40% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Panama City to Mexico City?

Use this chart to determine the cheapest time to fly round-trip from Panama City to Mexico City. Price data was last updated on January 24, 2026.

Travelers seeking maximum savings on their Panama City to Mexico City flight should consider departing on Tuesday evenings when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Panama City to Mexico City?

The best insider tips for Panama City to Mexico City flights

AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Mexico City trip
Our travel experts
Brandon Schultz

Brandon Schultz

Expert on MEX

Brandon Schultz is an award-winning food and travel writer based in New York City. His work has appeared in Forbes, AAA, Thrillist, Travel + Leisure, and The Daily Meal, among many others, and he is the author of 6 books, including 3 cookbooks.

Read more
Taryn White

Taryn White

Expert on PTY

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated enero 29, 2026.
See what other customers who have flown with Copa Airlines, Aeromexico, and Avianca from Panama City to Mexico City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,560 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.5
Good
1,560 reviews
Copa Airlines
7.5
Good
1,560 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Aeromexico
7.4
Good
1,586 reviews
Copa Airlines
7.5
Good
1,560 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Avianca
6.6
Okay
2,492 reviews
Copa Airlines
7.5
Good
1,560 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Mexico City?

    Booking a flight from Panama City Tocumen Intl (PTY) to Mexico City Benito Juarez (MEX) is your only option if you wish to fly from Panama City to Mexico City. On a typical day, there are 7 flights from Tocumen Intl to Benito Juarez, all of which are around 3h 43m for a nonstop flight. You can also purchase a plane ticket from 3 airlines when you book a flight from Tocumen Intl to Mexico City.

  • How popular is this Panama City to Mexico City flight route?

    The Panama City Tocumen Intl to Mexico City Benito Juarez flight path was viewed by 7 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Mexico City?

    There are many flights that can get you from Panama City to Mexico City in 3h 51m. Fly via Avianca or Copa Airlines to get the fastest option. There are 1497 mi between Panama City and Mexico City. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City to Mexico City round-trip?

    Cheapflights users have booked flights from Panama City to Mexico City round-trip from $183. Other airlines that can offer you cheap pricing are Copa Airlines, from $201, and Avianca, from $214. Aeromexico is 52% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City to Mexico City one-way?

    The cheapest airline one-way is Avianca, with whom users have recently found tickets for as low as $157. However, be on the lookout for offers from Aeromexico and Copa Airlines, as they are both options that can get you from Panama City to Mexico City for a low price.

  • What are the most reliable airlines from Panama City to Mexico City?

    The top 3 most reliable airlines when flying from Panama City to Mexico City are AeroMexico Connect (97%), Copa Airlines (94%) and Aeromexico (93%).

  • What are the cheapest flights from Panama City to Mexico City?

    Looking for the cheapest flight from Panama City to Mexico City? While on average our users pay $406, our data indicates the cheapest price to be $261. The most popular route (Panama City Tocumen Intl - Mexico City Benito Juarez), is priced around $333.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of $171). Flying from Panama City to Mexico City in March is currently the most expensive (average of $322). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mexico City?

Book flights to Mexico City if you plan to visit one of these locations
Taxco

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Top 3 airlines flying from Panama City to Mexico City

Discover the top 3 airlines that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$183Average$344FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$201Average$415FlexibilityNo cancel feeOn-time70%
AviancaCheapest$214Average$423FlexibilityNo cancel feeOn-time71%

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