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$175+ Cheap flights from Panama City (PTY) to Mexico City (MEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/24. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
Jan 13 — Jan 201
Tue 1/13
Tue 1/20
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Mexico City Benito Juarez are usually found in July or August, booked 81 days in advance, depart on a Tuesday or Thursday and return on a Wednesday

Cheap flight deals from Panama City to Mexico City

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.

This Copa Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:18 amPTY - MEX
Nonstop3h 52mCopa Airlines
Tue 12/303:30 pmMEX - PTY
Nonstop3h 45mCopa Airlines
Deal found 12/12$276
This Copa Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:14 pmPTY - MEX
Nonstop3h 46mCopa Airlines
Sat 1/101:10 pmMEX - PTY
Nonstop3h 38mCopa Airlines
Deal found 12/12$310
This Copa Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:18 amPTY - MEX
Nonstop3h 52mCopa Airlines
Sat 12/272:00 amMEX - PTY
Nonstop3h 41mCopa Airlines
Deal found 12/12$331
This Copa Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:28 pmPTY - MEX
Nonstop3h 47mCopa Airlines
Mon 1/53:30 pmMEX - PTY
Nonstop3h 37mCopa Airlines
Deal found 12/12$344
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/272:55 pmPTY - MEX
Nonstop4h 05mAeromexico
Tue 12/308:55 amMEX - PTY
Nonstop3h 45mAeromexico
Deal found 12/12$354
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:50 pmPTY - MEX
1 stop16h 30mMultiple Airlines
Tue 12/309:25 amMEX - PTY
Nonstop3h 49mMultiple Airlines
Deal found 12/12$361
This Copa Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:14 pmPTY - MEX
Nonstop3h 46mCopa Airlines
Tue 12/301:10 pmMEX - PTY
Nonstop3h 46mCopa Airlines
Deal found 12/12$365
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:38 amPTY - MEX
Nonstop3h 52mCopa Airlines
Fri 12/261:20 amMEX - PTY
Nonstop3h 40mCopa Airlines
Deal found 12/12$378
This Copa Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/299:18 amPTY - MEX
Nonstop3h 52mCopa Airlines
Sat 1/35:55 amMEX - PTY
Nonstop3h 40mCopa Airlines
Deal found 12/13$387
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:55 pmPTY - MEX
Nonstop4h 05mMultiple Airlines
Fri 12/264:00 amMEX - PTY
1 stop5h 30mMultiple Airlines
Deal found 12/12$394
This Cheapflightsfares deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:45 amPTY - MEX
1 stop9h 25mAvianca
Sun 12/284:50 pmMEX - PTY
1 stop16h 40mAvianca
Deal found 12/12$417
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:18 amPTY - MEX
Nonstop3h 52mMultiple Airlines
Fri 12/264:00 amMEX - PTY
1 stop5h 30mMultiple Airlines
Deal found 12/12$420

Find flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 14, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$276
(Copa Airlines)

One-way from

$175
(Cheapflightsfares)

Popular in

June

Cheapest in

July

Average price

$362

Good round-trip deal

$247 or less

Good one-way deal

$284 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Mexico City Benito Juarez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Mexico City Benito Juarez flights.
Search Deals
From Panama City Tocumen Intl to Mexico City Benito Juarez
Search Deals
One-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($4 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($3 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Mexico City Benito Juarez.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Panama City

Fly to

Mexico City

Route

Depart

Return

Price

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 12/25

9:18 am-12:10 pm

Nonstop3h 52m

Mexico City Benito Juarez

Wed 12/31

1:10 pm-5:56 pm

Nonstop3h 46m

$276

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 12/30

10:14 pm-1:00 am

Nonstop3h 46m

Mexico City Benito Juarez

Fri 1/2

1:10 pm-5:48 pm

Nonstop3h 38m

$276

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 12/30

9:28 pm-12:15 am

Nonstop3h 47m

Mexico City Benito Juarez

Sat 1/10

9:25 am-2:06 pm

Nonstop3h 41m

$310

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 12/25

9:18 am-12:10 pm

Nonstop3h 52m

Mexico City Benito Juarez

Sat 12/27

2:00 am-6:41 am

Nonstop3h 41m

$331

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 3/13

9:45 am-6:10 pm

1 stop9h 25m

Mexico City Benito Juarez

Fri 3/20

11:10 pm-8:50 am

1 stop8h 40m

$333

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 2/7

2:55 am-12:10 pm

1 stop10h 15m

Mexico City Benito Juarez

Sun 2/15

5:00 am-2:00 pm

1 stop8h 00m

$351

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 2/7

6:57 pm-10:00 pm

Nonstop4h 03m

Mexico City Benito Juarez

Tue 2/17

3:30 pm-8:07 pm

Nonstop3h 37m

$351

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 3/13

9:26 pm-12:15 am

Nonstop3h 49m

Mexico City Benito Juarez

Fri 3/20

9:25 am-2:04 pm

Nonstop3h 39m

$351

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 2/13

11:45 am-2:30 pm

Nonstop3h 45m

Mexico City Benito Juarez

Fri 2/20

9:25 am-2:06 pm

Nonstop3h 41m

$351

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 1/28

9:21 am-12:10 pm

Nonstop3h 49m

Mexico City Benito Juarez

Tue 2/3

2:00 am-6:41 am

Nonstop3h 41m

$351

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/13

Showing 1-10 of 22 results
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Compare providers for flights from Panama City to Mexico City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Mexico City in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Mexico City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Mexico City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Mexico City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Mexico City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Mexico City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Mexico City. Price data was last updated on December 12, 2025.

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 81 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of $171). Flying from Panama City to Mexico City in March is currently the most expensive (average of $347). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 14, 2025.

It’s typically best to fly out from Panama City to Mexico City at noon. Doing so could potentially save you 42% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Panama City to Mexico City?

Use this chart to determine the cheapest time to fly round-trip from Panama City to Mexico City. Price data was last updated on December 13, 2025.

Travelers seeking maximum savings on their Panama City to Mexico City flight should consider departing on Friday at noon when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

The best insider tips for Panama City to Mexico City flights

AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Mexico City trip
Airports
PTY

For a smooth departure, use authorized taxis or Uber from PTY to Panama City. Confirm taxi rates before leaving the airport.

Read more about PTYBy Taryn White
MEX

For a quick arrival at MEX, consider using Uber. It's cheaper and more reliable than taxis for reaching downtown Mexico City.

Read more about MEXBy Brandon Schultz
Our travel experts
Brandon Schultz

Brandon Schultz

Expert on MEX

Brandon Schultz

Brandon Schultz

Brandon Schultz is an award-winning food and travel writer based in New York City. His work has appeared in Forbes, AAA, Thrillist, Travel + Leisure, and The Daily Meal, among many others, and he is the author of 6 books, including 3 cookbooks.

Read more
Taryn White

Taryn White

Expert on PTY

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated December 14, 2025.
See what other customers who have flown with Copa Airlines, Aeromexico, and Avianca from Panama City to Mexico City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Food

6.8

Overall

7.6

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,557 reviews
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Food

6.8

Overall

7.6

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Aeromexico
7.4
Good
1,636 reviews
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Food

6.8

Overall

7.6

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,485 reviews
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Food

6.8

Overall

7.6

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Mexico City?

    Booking a flight from Panama City Tocumen Intl (PTY) to Mexico City Benito Juarez (MEX) is your only option if you wish to fly from Panama City to Mexico City. On a typical day, there are 8 flights from Tocumen Intl to Benito Juarez, all of which are around 3h 38m for a nonstop flight. You can also purchase a plane ticket from 3 airlines when you book a flight from Tocumen Intl to Mexico City.

  • How popular is this Panama City to Mexico City flight route?

    The Panama City Tocumen Intl to Mexico City Benito Juarez flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Mexico City?

    There are many flights that can get you from Panama City to Mexico City in 3h 52m. Fly via Copa Airlines or Avianca to get the fastest option. There are 1497 mi between Panama City and Mexico City. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City to Mexico City round-trip?

    Cheapflights users have booked flights from Panama City to Mexico City round-trip from $192. Other airlines that can offer you cheap pricing are Avianca, from $214, and Copa Airlines, from $222. Aeromexico is 50% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City to Mexico City one-way?

    The cheapest airline one-way is Avianca, with whom users have recently found tickets for as low as $157. However, be on the lookout for offers from Aeromexico and Copa Airlines, as they are both options that can get you from Panama City to Mexico City for a low price.

  • What are the most reliable airlines from Panama City to Mexico City?

    The top 3 most reliable airlines when flying from Panama City to Mexico City are Copa Airlines (95%), AeroMexico Connect (92%) and Aeromexico (92%).

  • What are the cheapest flights from Panama City to Mexico City?

    Looking for the cheapest flight from Panama City to Mexico City? While on average our users pay $405, our data indicates the cheapest price to be $178. The most popular route (Panama City Tocumen Intl - Mexico City Benito Juarez), is priced around $342.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of $171). Flying from Panama City to Mexico City in March is currently the most expensive (average of $347). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mexico City?

Book flights to Mexico City if you plan to visit one of these locations
Taxco

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Top 3 airlines flying from Panama City to Mexico City

Discover the top 3 airlines that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$195Average$344FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$242Average$418FlexibilityNo cancel feeOn-time70%
AviancaCheapest$293Average$438FlexibilityNo cancel feeOn-time71%

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