$173+ Cheap flights from Des Moines (DSM) to Mexico City Federal District
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Mar 6 — Mar 131
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Mexico City Federal District
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Cheapest flights from Des Moines to Mexico City Federal DistrictExplore the most affordable flight options available from Des Moines to Mexico City Federal District. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
Explore the most affordable flight options available from Des Moines to Mexico City Federal District. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
- MEX
1 stop21h 44m
Multiple Airlines
Wed 3/258:10 am
MEX
- DSM
1 stop10h 06m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- MEX
2 stops26h 09m
Multiple Airlines
Fri 3/138:10 am
MEX
- DSM
1 stop10h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$444
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
- MEX
1 stop21h 38m
Multiple Airlines
Tue 3/1010:05 pm
MEX
- DSM
2 stops20h 11m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$446
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:22 pm
DSM
- MEX
1 stop24h 43m
Multiple Airlines
Fri 3/271:20 pm
MEX
- DSM
2 stops28h 56m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$464
This Priceline deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
- MEX
2 stops26h 09m
Frontier
Tue 3/103:45 pm
MEX
- DSM
2 stops26h 31m
Frontier
Deal found 2/3![Frontier logo]()
$506
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:27 pm
DSM
- MEX
1 stop21h 38m
Multiple Airlines
Wed 3/188:10 am
MEX
- DSM
1 stop10h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$512
Best flights from Des Moines to Mexico City Federal DistrictDiscover carefully curated flight deals from Des Moines to Mexico City Federal District that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
Discover carefully curated flight deals from Des Moines to Mexico City Federal District that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
- MEX
1 stop21h 44m
Multiple Airlines
Wed 3/258:10 am
MEX
- DSM
1 stop10h 06m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$403
This Priceline deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
- MEX
2 stops27h 03m
Frontier
Tue 3/103:45 pm
MEX
- DSM
2 stops26h 31m
Frontier
Deal found 2/1![Frontier logo]()
$522
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
- MEX
1 stop21h 38m
Multiple Airlines
Tue 3/1010:05 pm
MEX
- DSM
2 stops20h 11m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$446
This CheapOair deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
- MEX
2 stops26h 39m
Frontier
Tue 3/247:00 am
MEX
- DSM
2 stops35h 16m
Frontier
Deal found 2/1![Frontier logo]()
$523
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:22 pm
DSM
- MEX
1 stop24h 43m
Multiple Airlines
Fri 3/271:20 pm
MEX
- DSM
2 stops28h 56m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$480
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:27 pm
DSM
- MEX
1 stop21h 38m
Multiple Airlines
Wed 3/188:10 am
MEX
- DSM
1 stop10h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$512
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
- MEX
2 stops15h 59m
Multiple Airlines
Tue 3/1011:00 am
MEX
- DSM
1 stop28h 02m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$519
Last-minute flights from Des Moines to Mexico City Federal DistrictDiscover last-minute flight deals from Des Moines to Mexico City Federal District. Data last updated February 4, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico City Federal District. Data last updated February 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:27 pm
DSM
- MEX
1 stop21h 38m
Multiple Airlines
Wed 3/188:10 am
MEX
- DSM
1 stop10h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$512
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
- MEX
1 stop21h 38m
Multiple Airlines
Tue 3/1010:05 pm
MEX
- DSM
2 stops20h 11m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$446
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- MEX
2 stops26h 09m
Multiple Airlines
Fri 3/138:10 am
MEX
- DSM
1 stop10h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$444
This Priceline deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
- MEX
2 stops26h 09m
Frontier
Tue 3/103:45 pm
MEX
- DSM
2 stops26h 31m
Frontier
Deal found 2/3![Frontier logo]()
$506
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
- MEX
1 stop21h 44m
Multiple Airlines
Wed 3/258:10 am
MEX
- DSM
1 stop10h 06m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:22 pm
DSM
- MEX
1 stop24h 43m
Multiple Airlines
Fri 3/271:20 pm
MEX
- DSM
2 stops28h 56m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$464
One-way flights from Des Moines to Mexico City Federal DistrictSearch for one-way flight options from Des Moines to Mexico City Federal District. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
Search for one-way flight options from Des Moines to Mexico City Federal District. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:27 pm
DSM
- MEX
1 stop21h 38m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/168:21 pm
DSM
- MEX
2 stops24h 59m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:11 pm
DSM
- MEX
1 stop28h 34m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:59 am
DSM
- MEX
3 stops34h 01m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/295:05 pm
DSM
- MEX
3 stops41h 40m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/110:59 am
DSM
- MEX
3 stops37h 06m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$293
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:45 am
DSM
- MEX
2 stops10h 25m
Delta
Deal found 2/1![Delta logo]()
$294
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:30 pm
DSM
- MEX
2 stops14h 50m
Delta
Deal found 2/1![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:20 am
DSM
- MEX
1 stop10h 20m
United Airlines
Deal found 2/1![United Airlines logo]()
$321
Find flight deals from Des Moines to Mexico City Federal District
Keep the following information in mind while searching for Des Moines to Mexico City Federal District flight deals. Data was last updated February 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $402 (Kiwi.com) |
One-way from | $173 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $575 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico City Federal District that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico City Federal District that are best for you.
Fly from
Des Moines
Fly to
Mexico City Federal District
Route
Depart
Return
Price
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Wed 3/18
8:21 pm-5:05 pm
1 stop21h 44m
Mexico City Benito Juarez
Wed 3/25
8:10 am-7:16 pm
1 stop10h 06m
$403
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Thu 3/5
7:27 pm-5:05 pm
1 stop21h 38m
Mexico City Benito Juarez
Tue 3/10
10:05 pm-7:16 pm
2 stops20h 11m
$446
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Fri 3/20
8:22 pm-8:05 pm
1 stop24h 43m
Mexico City Benito Juarez
Fri 3/27
1:20 pm-7:16 pm
2 stops28h 56m
$480
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Thu 2/26
7:27 pm-5:05 pm
1 stop21h 38m
Mexico City Benito Juarez
Wed 3/18
8:10 am-7:16 pm
1 stop10h 06m
$512
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Sat 3/7
8:21 pm-12:20 pm
2 stops15h 59m
Mexico City Benito Juarez
Tue 3/10
11:00 am-4:02 pm
1 stop28h 02m
$519
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Thu 3/5
7:27 pm-10:30 pm
2 stops27h 03m
Mexico City Benito Juarez
Tue 3/10
3:45 pm-7:16 pm
2 stops26h 31m
$522
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Wed 3/18
8:21 pm-10:00 pm
2 stops26h 39m
Mexico City Benito Juarez
Tue 3/24
7:00 am-7:16 pm
2 stops35h 16m
$523
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Thu 2/26
7:27 pm-5:05 pm
1 stop21h 38m
$173
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Tue 6/30
4:11 pm-7:45 pm
1 stop28h 34m
$248
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Wed 7/8
10:59 am-8:00 pm
3 stops34h 01m
$255
Showing 1-10 of 16 results
Best time to book a flight from Des Moines to Mexico City Federal District
Have a flexible travel schedule? Discover the best time to fly to Mexico City Federal District from Des Moines with our price prediction graph.
DSM-MEX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico City Federal District
DSM-MXDF
DSM-MEX
What is the cheapest month to book a flight from Des Moines to Mexico City Federal District?
Currently, August is the cheapest month in which you can book a flight from Des Moines to Mexico City Federal District (average of $375). Flying from Des Moines to Mexico City Federal District in January is currently the most expensive (average of $591). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico City Federal District
Get insights into the airlines that provide service to Mexico City Federal District. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City Federal District. Reviews last updated February 4, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to Mexico City Federal District. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico City Federal District. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Find flights from Des Moines to Mexico City Federal District, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Mexico City Federal District flights
Browse other Des Moines and Mexico City Federal District flight options. Last updated on February 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Mexico City Federal District
Discover the top 3 airlines that operate flights from Des Moines to Mexico City Federal District. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$373 | Average$602 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$379 | Average$583 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$382 | Average$654 | FlexibilityNo cancel fee | On-time71% |