Which airline has the best punctuality record on Panama City to Madrid flights?

Over the last year, Pascan have had the lowest number of delays on this route, with just 6% of flights being delayed.

How often are flights from Panama City to Madrid delayed?

About 14% of weekly flights between Panama City and Madrid have experienced delays in the past year, with the average delay time being 133 minutes.

What day of the week experiences the fewest flight delays on this route?

Monday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.

What is the most punctual flight time for Panama City to Madrid flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

How popular is this Panama City to Madrid flight route?

This flight path from Panama City Tocumen Intl to Madrid Barajas was viewed by 20 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from Panama City to Madrid?

A quick flight from Panama City to Madrid can take about 9h 50m. Turkish Airlines provides one of the quickest options available for as low as $757. The distance between Panama City and Madrid is about 5065 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Panama City to Madrid round-trip?

Avianca, at $597, was found to be the cheapest airline from Panama City to Madrid.Alternate airlines to your destination round-trip include KLM and Air Europa. Avianca is 23% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Panama City to Madrid one-way?

One-way options have recently been found by users for as low as $434 on Turkish Airlines. Other airlines that offer cheap prices include Air Europa from $510 and Avianca from $541 one-way.

Weekly flight availability from Panama City to Madrid

The most flights from PTY to MAD are scheduled on a Monday (10 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (3 on average).

In terms of precipitation, rainfall in Madrid ranges from 0.4 - 2.4 inches per month. November is typically the wettest month, when rainfall can reach 2.4 in. July is typically the driest time to visit Madrid when rainfall is around 0.4 in.

If weather is an important factor for your trip to Madrid, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What are the cheapest flights from Panama City to Madrid?

Looking for the cheapest flight from Panama City to Madrid? While on average our users pay $1,559, our data indicates the cheapest price to be $603. The most popular route (Panama City Tocumen Intl - Madrid Barajas), is priced around $655.

What are the most reliable airlines from Panama City to Madrid?

Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Panama City to Madrid on time: Qatar Airways (81%), Iberia (81%), EL AL (81%).

What are the most popular airlines that fly from Panama City to Madrid?

The most popular airlines flying from Panama City to Madrid are Air Europa, Iberia and Avianca. Something to consider prior to booking your flight.

Most accurate provider : When it comes to deals on Panama City-Madrid flights, users find the pricing of CheapOair to be most consistent on Cheapflights vs. CheapOair Users can find the same prices on Panama City-Madrid flight deals on Cheapflights vs. CheapOair >95% of the time. Price accuracy is based on data collected from Panama City-Madrid flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City-Madrid flights, Cheapflights users trust CheapOair the most. CheapOair has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Madrid flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

What airports do I use to fly from Panama City to Madrid?

Madrid Barajas is the airport most travelers will use when flying to Madrid from Panama City Tocumen Intl. Booking flights from Tocumen Intl (PTY) to Barajas (MAD) should be relatively easy as there are 6 daily flights to Madrid from 7 different airlines. 9h 35m is how long a flight from Panama City to Madrid Barajas will take if you book a nonstop flight.

Can I find deals for flights from Panama City to Madrid that include hotel bookings?

Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Madrid?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

Can I find deals for business class flights from Panama City to Madrid?

Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$512+ Flights from Panama City to Madrid, Spain

Q: How much does it cost to fly round-trip from Panama City to Madrid?

Airfare is below average for this route at the moment. Panama City to Madrid flights typically cost between $717 and $1,033 in April. The cheapest round-trip price found within the last 3 days was $708 on Air Europa (Apr 13-Apr 20).

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Panama City to Madrid with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in March or May, booked 58 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Panama City to Madrid

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Sun 12/286:45 pmPTY - MAD

1 stop33h 30mMultiple Airlines

Mon 1/196:45 pmMAD - PTY

1 stop31h 25mMultiple Airlines

Deal found 12/26

$911

Mon 12/296:45 pmPTY - MAD

1 stop33h 30mKLM

Sat 1/31:05 pmMAD - PTY

1 stop33h 25mKLM

Deal found 12/27

$926

Tue 12/306:45 pmPTY - MAD

1 stop22h 40mKLM

Sun 1/184:50 pmMAD - PTY

1 stop29h 40mKLM

Deal found 12/25

$948

Mon 12/296:20 pmPTY - MAD

Nonstop10h 05mIberia

Thu 1/153:50 pmMAD - PTY

2 stops51h 37mIberia

Deal found 12/26

$963

Tue 12/306:45 pmPTY - MAD

1 stop33h 30mMultiple Airlines

Wed 1/146:00 amMAD - PTY

1 stop20h 10mMultiple Airlines

Deal found 12/26

$1,022

Mon 12/296:45 pmPTY - MAD

1 stop33h 30mMultiple Airlines

Mon 1/1210:00 amMAD - PTY

1 stop16h 10mMultiple Airlines

Deal found 12/25

$1,024

Fri 12/2610:20 pmPTY - MAD

1 stop18h 45mAir France

Sun 1/116:45 pmMAD - PTY

1 stop31h 25mAir France

Deal found 12/26

$1,041

Wed 12/3110:20 pmPTY - MAD

1 stop18h 45mMultiple Airlines

Thu 1/156:00 amMAD - PTY

1 stop16h 30mMultiple Airlines

Deal found 12/26

$1,044

Wed 12/3110:20 pmPTY - MAD

1 stop18h 45mAir France

Thu 1/156:45 pmMAD - PTY

1 stop31h 25mAir France

Deal found 12/27

$1,068

Tue 12/306:45 pmPTY - MAD

1 stop22h 40mKLM

Thu 1/156:00 amMAD - PTY

1 stop16h 30mKLM

Deal found 12/26

$1,081

Fri 12/261:56 pmPTY - MAD

1 stop15h 24mMultiple Airlines

Fri 1/303:10 pmMAD - PTY

Nonstop10h 35mMultiple Airlines

Deal found 12/26

$1,086

Best flights from Panama City to Madrid
Discover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 28, 2025.

Wed 3/119:45 pmPTY - MAD

1 stop30h 40mTurkish Airlines

Mon 3/2311:55 amMAD - PTY

2 stops35h 10mTurkish Airlines

Deal found 12/27

$739

Fri 5/89:30 pmPTY - MAD

Nonstop9h 50mIberia

Wed 5/133:55 pmMAD - PTY

Nonstop11h 05mIberia

Deal found 12/28

$757

Fri 5/296:50 pmPTY - MAD

1 stop21h 35mMultiple Airlines

Sat 6/66:00 amMAD - PTY

2 stops17h 50mMultiple Airlines

Deal found 12/27

$813

Wed 4/2910:20 pmPTY - MAD

1 stop32h 15mTurkish Airlines

Sat 5/167:30 amMAD - PTY

2 stops41h 55mTurkish Airlines

Deal found 12/26

$739

Fri 6/56:50 pmPTY - MAD

1 stop31h 40mMultiple Airlines

Sat 6/205:45 pmMAD - PTY

1 stop33h 00mMultiple Airlines

Deal found 12/26

$814

Wed 3/259:45 pmPTY - MAD

1 stop36h 40mTurkish Airlines

Tue 3/317:30 amMAD - PTY

2 stops41h 55mTurkish Airlines

Deal found 12/27

$748

Wed 4/1510:20 pmPTY - MAD

1 stop35h 35mTurkish Airlines

Wed 4/292:40 pmMAD - PTY

2 stops34h 50mTurkish Airlines

Deal found 12/27

$761

Sun 2/226:45 pmPTY - MAD

1 stop36h 35mTurkish Airlines

Fri 3/135:55 pmMAD - PTY

1 stop31h 55mTurkish Airlines

Deal found 12/27

$761

Tue 3/176:45 pmPTY - MAD

1 stop22h 45mTurkish Airlines

Sat 4/1112:00 pmMAD - PTY

2 stops37h 25mTurkish Airlines

Deal found 12/28

$773

Mon 2/29:45 pmPTY - MAD

1 stop30h 40mTurkish Airlines

Mon 2/1611:55 amMAD - PTY

2 stops35h 10mTurkish Airlines

Deal found 12/26

$792

Sun 3/86:45 pmPTY - MAD

1 stop22h 45mTurkish Airlines

Sat 3/142:25 pmMAD - PTY

2 stops32h 40mTurkish Airlines

Deal found 12/28

$803

Last-minute flights from Panama City to Madrid
Discover last-minute flight deals from Panama City to Madrid. Data last updated December 28, 2025 and is based on user searches.

Wed 12/312:55 amPTY - MAD

1 stop14h 25mAvianca

Fri 1/94:20 pmMAD - PTY

1 stop14h 20mAvianca

Deal found 12/26

$1,464

Fri 1/29:30 pmPTY - MAD

Nonstop9h 35mMultiple Airlines

Fri 1/234:00 amMAD - PTY

1 stop18h 27mMultiple Airlines

Deal found 12/26

$1,514

Sat 1/39:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Sat 1/313:10 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 12/25

$1,399

Sat 1/39:30 pmPTY - MAD

Nonstop9h 35mMultiple Airlines

Sat 1/316:40 amMAD - PTY

1 stop24h 20mMultiple Airlines

Deal found 12/26

$1,523

Mon 1/59:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Fri 3/273:10 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 12/27

$1,452

Mon 1/59:30 pmPTY - MAD

Nonstop9h 35mMultiple Airlines

Thu 3/261:45 amMAD - PTY

1 stop20h 59mMultiple Airlines

Deal found 12/27

$1,462

Mon 1/52:55 pmPTY - MAD

1 stop26h 25mAvianca

Fri 3/2710:50 amMAD - PTY

1 stop28h 00mAvianca

Deal found 12/26

$1,480

Mon 1/59:45 pmPTY - MAD

1 stop33h 35mTurkish Airlines

Sat 7/187:30 amMAD - PTY

1 stop19h 55mTurkish Airlines

Deal found 12/26

$1,520

Mon 1/59:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Sat 7/183:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 12/27

$1,527

One-way flights from Panama City to Madrid
Search for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated December 28, 2025.

Mon 1/199:33 pmPTY - MAD

2 stops52h 47mMultiple Airlines

Deal found 12/26

$512

Mon 2/239:33 pmPTY - MAD

2 stops36h 27mMultiple Airlines

Deal found 12/27

$528

Wed 3/112:55 pmPTY - MAD

2 stops16h 55mAvianca

Deal found 12/26

$557

Wed 1/282:55 amPTY - MAD

1 stop28h 30mAvianca

Deal found 12/26

$572

Mon 1/199:45 amPTY - MAD

1 stop17h 05mAvianca

Deal found 12/26

$573

Tue 3/102:55 amPTY - MAD

3 stops26h 15mMultiple Airlines

Deal found 12/26

$585

Wed 3/182:55 pmPTY - MAD

2 stops16h 55mAvianca

Deal found 12/26

$594

Mon 2/239:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 12/27

$615

Sat 1/106:34 pmPTY - MAD

2 stops41h 31mMultiple Airlines

Deal found 12/26

$622

Fri 2/209:45 amPTY - MAD

2 stops46h 05mAvianca

Deal found 12/26

$623

Fri 2/209:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 12/26

$624

Find flight deals from Panama City to Madrid

Most accurate provider	CheapOair 3 stars
Most trusted provider	CheapOair 3 stars
Round-trip from	$710 (Gotogate)
One-way from	$512 (Kiwi.com)
Popular in	December
Cheapest in	March
Average price	$928
Good round-trip deal	$773 or less
Good one-way deal	$657 or less

Provider with most accurate pricing for Panama City Tocumen Intl-Madrid Barajas flight deals.

Search Deals

Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Madrid Barajas flights.

Search Deals

From Panama City Tocumen Intl to Madrid Barajas

Search Deals

One-way flight from Panama City Tocumen Intl to Madrid Barajas

Search Deals

Highest demand for flights based on searches. 5% potential increase in price ($47 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Price to beat on a round-trip flight from Panama City Tocumen Intl to Madrid Barajas.

Search Deals

Price to beat on a one-way flight from Panama City Tocumen Intl to Madrid Barajas.

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 3/11

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Mon 3/23

11:55 am-5:05 pm

2 stops35h 10m

$739

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 4/29

10:20 pm-1:35 pm

1 stop32h 15m

Madrid Barajas

Sat 5/16

7:30 am-6:25 pm

2 stops41h 55m

$739

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 3/25

9:45 pm-4:25 pm

1 stop36h 40m

Madrid Barajas

Tue 3/31

7:30 am-6:25 pm

2 stops41h 55m

$748

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/8

9:30 pm-2:20 pm

Nonstop9h 50m

Madrid Barajas

Wed 5/13

3:55 pm-8:00 pm

Nonstop11h 05m

$757

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 4/15

10:20 pm-4:55 pm

1 stop35h 35m

Madrid Barajas

Wed 4/29

2:40 pm-6:30 pm

2 stops34h 50m

$761

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 2/22

6:45 pm-1:20 pm

1 stop36h 35m

Madrid Barajas

Fri 3/13

5:55 pm-7:50 pm

1 stop31h 55m

$761

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 3/17

6:45 pm-11:30 pm

1 stop22h 45m

Madrid Barajas

Sat 4/11

12:00 pm-6:25 pm

2 stops37h 25m

$773

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/2

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Mon 2/16

11:55 am-5:05 pm

2 stops35h 10m

$792

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 3/8

6:45 pm-11:30 pm

1 stop22h 45m

Madrid Barajas

Sat 3/14

2:25 pm-5:05 pm

2 stops32h 40m

$803

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/29

6:50 pm-11:25 pm

1 stop21h 35m

Madrid Barajas

Sat 6/6

6:00 am-4:50 pm

2 stops17h 50m

$813

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/26

Showing 1-10 of 21 results

Compare providers for flights from Panama City to Madrid

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Madrid in December.

Provider	Price Accuracy	Trust Score*
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
CheapOair	Price Accuracy3 stars	Trust Score*3 stars
Gotogate	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City-Madrid flights, users find the pricing of CheapOair to be most consistent on Cheapflights vs. CheapOair Users can find the same prices on Panama City-Madrid flight deals on Cheapflights vs. CheapOair >95% of the time. Price accuracy is based on data collected from Panama City-Madrid flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City-Madrid flights, Cheapflights users trust CheapOair the most. CheapOair has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Madrid flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

Prices

Airlines

Delays

How far ahead should I book a flight from Panama City to Madrid?

The price you pay for your flight from Panama City to Madrid may vary depending on when you book. For the best chance of a lower fare, look to book 58 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, April is the cheapest month in which you can book a flight from Panama City to Madrid (average of $595). Flying from Panama City to Madrid in July is currently the most expensive (average of $711). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

When flying from Panama City to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Panama City to Madrid?

The best insider tips for Panama City to Madrid flights

Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Madrid trip

Airports

PTY

For nighttime flights, bring snacks as most eateries close by 10 pm at PTY, ensuring you're not left hungry during your journey.

MAD

Upon arrival at MAD, rideshares like Uber and Cabify offer quick, affordable transport to the city center from dedicated pickup points.

Our travel experts

Lori Zaino

Expert on MAD

Taryn White

Expert on PTY

Reviews of airlines servicing Madrid

Get a feel of what it's like to fly with Copa Airlines, Air France, and Air Europa from Panama City to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.6

Good

1,561 reviews

Reviews

1 / 20

2.0

Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Copa Airlines

7.6

Good

1,561 reviews

Copa Airlines

7.6

Good

1,561 reviews

Reviews

1 / 20

2.0

Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Air France

7.4

Good

1,515 reviews

Copa Airlines

7.6

Good

1,561 reviews

Reviews

1 / 20

2.0

Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Air Europa

7.0

Good

577 reviews

Copa Airlines

7.6

Good

1,561 reviews

Reviews

1 / 20

2.0

Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Iberia

7.0

Good

3,059 reviews

Copa Airlines

7.6

Good

1,561 reviews

Reviews

1 / 20

2.0

Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Avianca

6.6

Okay

2,489 reviews

Copa Airlines

7.6

Good

1,561 reviews

Reviews

1 / 20

2.0

Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

What airports do I use to fly from Panama City to Madrid?
Madrid Barajas is the airport most travelers will use when flying to Madrid from Panama City Tocumen Intl. Booking flights from Tocumen Intl (PTY) to Barajas (MAD) should be relatively easy as there are 6 daily flights to Madrid from 7 different airlines. 9h 35m is how long a flight from Panama City to Madrid Barajas will take if you book a nonstop flight.
How popular is this Panama City to Madrid flight route?
This flight path from Panama City Tocumen Intl to Madrid Barajas was viewed by 20 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Panama City to Madrid?
A quick flight from Panama City to Madrid can take about 9h 50m. Turkish Airlines provides one of the quickest options available for as low as $757. The distance between Panama City and Madrid is about 5065 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Panama City to Madrid round-trip?
Avianca, at $597, was found to be the cheapest airline from Panama City to Madrid.Alternate airlines to your destination round-trip include KLM and Air Europa. Avianca is 23% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Panama City to Madrid one-way?
One-way options have recently been found by users for as low as $434 on Turkish Airlines. Other airlines that offer cheap prices include Air Europa from $510 and Avianca from $541 one-way.
What are the most reliable airlines from Panama City to Madrid?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Panama City to Madrid on time: Qatar Airways (81%), Iberia (81%), EL AL (81%).
What are the cheapest flights from Panama City to Madrid?
Looking for the cheapest flight from Panama City to Madrid? While on average our users pay $1,559, our data indicates the cheapest price to be $603. The most popular route (Panama City Tocumen Intl - Madrid Barajas), is priced around $655.
Can I find deals for flights from Panama City to Madrid that include hotel bookings?
Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Madrid?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.
Can I find deals for business class flights from Panama City to Madrid?
Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, April is the cheapest month in which you can book a flight from Panama City to Madrid (average of $595). Flying from Panama City to Madrid in July is currently the most expensive (average of $711). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Getafe

Browse thousands of different options on Cheapflights for your next trip

Complete your trip

Madrid car rentals

Madrid Barajas Airport car rentals

Barajas car rentals

Gran Via car rentals

Centro car rentals

Chamartin car rentals

Salamanca car rentals

Other flights to Madrid

Top 7 airlines flying from Panama City to Madrid

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$614	Average$734	FlexibilityNo cancel fee	On-time71%
KLM	Cheapest$654	Average$763	FlexibilityNo cancel fee	On-time75%
Air Europa	Cheapest$665	Average$825	FlexibilityNo cancel fee	On-time83%
Iberia	Cheapest$677	Average$831	FlexibilityNo cancel fee	On-time77%
Air France	Cheapest$695	Average$782	FlexibilityNo cancel fee	On-time77%
Turkish Airlines	Cheapest$698	Average$762	FlexibilityNo cancel fee	On-time77%
Copa Airlines	Cheapest$728	Average$1,274	FlexibilityNo cancel fee	On-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$512+ Cheap flights from Panama City (PTY) to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/19. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Madrid with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in March or May, booked 58 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Panama City to Madrid

Cheapest flights from Panama City to MadridExplore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Find flight deals from Panama City to Madrid

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Compare providers for flights from Panama City to Madrid

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Madrid in December.

Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

What is the cheapest month to book a flight from Panama City to Madrid?

What is the cheapest time of day to fly from PTY to MAD?

How much does it cost to fly round-trip from Panama City to Madrid?

Weekly flight availability from Panama City to Madrid

How often are flights from Panama City to Madrid delayed?

What is the most punctual flight time for Panama City to Madrid flights?

What day of the week experiences the fewest flight delays on this route?

Which airline has the best punctuality record on Panama City to Madrid flights?

The best insider tips for Panama City to Madrid flights

AI-powered summary based on content written by travel experts. AI can make mistakes.

Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Madrid trip

Airports

PTY

MAD

Our travel experts

Reviews of airlines servicing Madrid

Get a feel of what it's like to fly with Copa Airlines, Air France, and Air Europa from Panama City to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Panama City to Madrid?

How popular is this Panama City to Madrid flight route?

How long is the flight from Panama City to Madrid?

What are the cheapest airlines flying from Panama City to Madrid round-trip?

What are the cheapest airlines to fly from Panama City to Madrid one-way?

What are the most reliable airlines from Panama City to Madrid?

What are the cheapest flights from Panama City to Madrid?

Can I find deals for flights from Panama City to Madrid that include hotel bookings?

How can I find direct flights from Panama City to Madrid?

Can I find deals for business class flights from Panama City to Madrid?

What is the cheapest month to book a flight from Panama City to Madrid?

Traveling to a place near Madrid?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Madrid by adding a car rental and/or hotel reservation to your travel itinerary.

Top 7 airlines flying from Panama City to Madrid

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.