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$490+ Cheap flights from Panama City (PTY) to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/30. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Dec 14 — Dec 211
Sun 12/14
Sun 12/21
1 adult, Economy
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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

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3. Compare prices and book

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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in March or February, booked 58 days in advance, depart on a Tuesday or Thursday and return on a Wednesday

Cheap flight deals from Panama City to Madrid

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 14, 2025.

Most accurate provider

Gotogate
3 stars

Most trusted provider

Gotogate
3 stars

Round-trip from

$680
(KLM)

One-way from

$490
(Kiwi.com)

Popular in

December

Cheapest in

March

Average price

$745

Good round-trip deal

$810 or less

Good one-way deal

$635 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Madrid Barajas flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Madrid Barajas flights.
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From Panama City Tocumen Intl to Madrid Barajas
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One-way flight from Panama City Tocumen Intl to Madrid Barajas
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Highest demand for flights based on searches. 5% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Madrid Barajas.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Madrid Barajas.
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Find flight deals from Panama City to Madrid

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 14, 2025.

This Air France deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:20 pmPTY - MAD
1 stop28h 50mMultiple Airlines
Wed 1/216:00 amMAD - PTY
1 stop16h 30mMultiple Airlines
Deal found 11/11$731
This Turkish Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:45 pmPTY - MAD
1 stop40h 05mTurkish Airlines
Tue 12/25:55 pmMAD - PTY
1 stop31h 55mTurkish Airlines
Deal found 11/12$738
This Air Europa deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Fri 3/133:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/12$757
This British Airways deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/226:20 pmPTY - MAD
Nonstop10h 05mIberia
Sat 2/1411:40 amMAD - PTY
Nonstop11h 05mIberia
Deal found 11/13$775
This FlightHub deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Wed 3/43:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/13$778
This Avianca deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:55 amPTY - MAD
1 stop14h 25mAvianca
Wed 12/311:20 amMAD - PTY
1 stop13h 30mAvianca
Deal found 11/12$786
This Air Europa deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Fri 3/133:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/12$789
This KLM deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:45 pmPTY - MAD
1 stop18h 55mKLM
Wed 1/146:00 amMAD - PTY
1 stop19h 55mKLM
Deal found 11/12$801
This Avianca deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:55 amPTY - MAD
1 stop23h 55mAvianca
Wed 1/2110:50 amMAD - PTY
1 stop19h 50mAvianca
Deal found 11/12$809
This KLM deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:45 pmPTY - MAD
1 stop22h 40mMultiple Airlines
Wed 1/146:00 amMAD - PTY
1 stop20h 10mMultiple Airlines
Deal found 11/13$818

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 14, 2025.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Panama City

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/2

10:05 pm-10:15 am

1 stop30h 10m

Madrid Barajas

Mon 2/16

6:00 am-4:30 pm

1 stop16h 30m

$680

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 3/16

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Sun 3/29

2:40 pm-6:30 pm

2 stops34h 50m

$738

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 2/4

9:45 pm-1:20 pm

1 stop33h 35m

Madrid Barajas

Thu 2/26

5:55 pm-5:05 pm

2 stops29h 10m

$738

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 3/28

6:45 pm-3:55 pm

1 stop39h 10m

Madrid Barajas

Mon 4/20

12:00 pm-6:30 pm

2 stops37h 30m

$798

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 5/4

10:55 pm-6:40 am

2 stops24h 45m

Madrid Barajas

Tue 5/19

12:45 pm-2:14 pm

2 stops32h 29m

$847

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 5/5

10:55 pm-10:50 am

2 stops28h 55m

Madrid Barajas

Tue 5/19

11:15 am-4:12 pm

2 stops35h 57m

$853

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 3/31

9:45 am-4:45 pm

2 stops24h 00m

Madrid Barajas

Sun 4/19

12:45 pm-7:31 pm

2 stops37h 46m

$874

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 1/19

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Tue 1/27

2:25 pm-5:05 pm

2 stops32h 40m

$882

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 2/17

8:55 am-4:10 pm

2 stops25h 15m

Madrid Barajas

Tue 2/24

11:15 am-2:45 pm

2 stops33h 30m

$892

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 4/14

9:45 am-7:50 pm

2 stops27h 05m

Madrid Barajas

Tue 4/21

11:15 am-6:37 pm

2 stops38h 22m

$892

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/13

Showing 1-10 of 21 results
1
2
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Compare providers for flights from Panama City to Madrid

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Madrid in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
GotogatePrice Accuracy3 starsTrust Score*3 stars
CheapOairPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Madrid flights, users find the pricing of Gotogate to be most consistent on Cheapflights vs. Gotogate Users can find the same prices on Panama City-Madrid flight deals on Cheapflights vs. Gotogate >95% of the time. Price accuracy is based on data collected from Panama City-Madrid flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Madrid flights, Cheapflights users trust Gotogate the most. Gotogate has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Madrid flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Madrid. Price data was last updated on November 7, 2025.

The price you pay for your flight from Panama City to Madrid may vary depending on when you book. For the best chance of a lower fare, look to book 58 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, March is the cheapest month in which you can book a flight from Panama City to Madrid (average of $595). Flying from Panama City to Madrid in July is currently the most expensive (average of $708). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 14, 2025.

When flying from Panama City to Madrid, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 18% versus a flight at noon.

How much does it cost to fly round-trip from Panama City to Madrid?

The best insider tips for Panama City to Madrid flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Madrid trip
Airports
PTY

For nighttime flights, bring snacks as most eateries close by 10 pm at PTY, ensuring you're not left hungry during your journey.

Read more about PTYby Taryn White
MAD

Upon arrival at MAD, rideshares like Uber and Cabify offer quick, affordable transport to the city center from dedicated pickup points.

Read more about MADby Lori Zaino
Our travel experts
Lori Zaino

Lori Zaino

Expert on MAD

Lori Zaino

Lori Zaino

US-born but now based in Spain, Lori's visited 60 countries---and written about them for publications like CNN, Forbes, The Points Guy, NBC, and TripAdvisor. She loves combining affordable adventures with luxury travel experiences and feels equally at home salsa dancing in Colombia, sipping wine in a French castle, or backpacking through Malaysia.

Read more
Taryn White

Taryn White

Expert on PTY

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated November 14, 2025.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Air Europa from Panama City to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,487 reviews

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air France
7.4
Good
1,487 reviews
Air France
7.4
Good
1,487 reviews

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Turkish Airlines
7.3
Good
4,043 reviews
Air France
7.4
Good
1,487 reviews

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air Europa
7.0
Good
569 reviews
Air France
7.4
Good
1,487 reviews

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Iberia
7.0
Good
3,012 reviews
Air France
7.4
Good
1,487 reviews

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Avianca
6.6
Okay
2,476 reviews
Air France
7.4
Good
1,487 reviews

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Madrid?

    Madrid Barajas is the airport most travelers will use when flying to Madrid from Panama City Tocumen Intl. Booking flights from Tocumen Intl (PTY) to Barajas (MAD) should be relatively easy as there are 6 daily flights to Madrid from 8 different airlines. 9h 35m is how long a flight from Panama City to Madrid Barajas will take if you book a nonstop flight.

  • How popular is this Panama City to Madrid flight route?

    This flight path from Panama City Tocumen Intl to Madrid Barajas was viewed by 19 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Madrid?

    A quick flight from Panama City to Madrid can take about 28h 55m. KLM provides one of the quickest options available for as low as $853. The distance between Panama City and Madrid is about 5065 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City to Madrid round-trip?

    Avianca, at $614, was found to be the cheapest airline from Panama City to Madrid.Alternate airlines to your destination round-trip include KLM and Air Europa. Avianca is 21% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Panama City to Madrid?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Panama City to Madrid on time: Air Europa (89%), Etihad Airways (89%), China Eastern (89%).

  • What are the cheapest flights from Panama City to Madrid?

    Looking for the cheapest flight from Panama City to Madrid? While on average our users pay $858, our data indicates the cheapest price to be $526. The most popular route (Panama City Tocumen Intl - Madrid Barajas), is priced around $667.

  • Can I find deals for flights from Panama City to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

  • Can I find deals for business class flights from Panama City to Madrid?

    Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Madrid?

    Currently, March is the cheapest month in which you can book a flight from Panama City to Madrid (average of $595). Flying from Panama City to Madrid in July is currently the most expensive (average of $708). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Getafe

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Top 8 airlines flying from Panama City to Madrid

Discover the top 8 airlines that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$614Average$736FlexibilityNo cancel feeOn-time71%
KLMCheapest$654Average$786FlexibilityNo cancel feeOn-time75%
Air EuropaCheapest$661Average$805FlexibilityNo cancel feeOn-time83%
IberiaCheapest$677Average$828FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$697Average$786FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$768FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$822FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$728Average$1,232FlexibilityNo cancel feeOn-time70%

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