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$511+ Cheap flights from Panama to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
oct. 25 — nov. 11
sáb. 10/25
sáb. 11/1
1 adult, Economy
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Cheap flight deals from Panama to Madrid

Keep the following information in mind while searching for Panama to Madrid flight deals. Data was last updated septiembre 25, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$670
(Gotogate)

One-way from

$511
(KLM)

Popular in

July

Cheapest in

March

Average price

$818

Good round-trip deal

$714 or less

Good one-way deal

$524 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Madrid Barajas flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Madrid Barajas flights.
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From Panama to Madrid Barajas
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One-way flight from Panama to Madrid Barajas
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Highest demand for flights based on searches. 7% potential increase in price ($65 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Panama to Madrid Barajas.
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Price to beat on a one-way flight from Panama to Madrid Barajas.
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Find flight deals from Panama to Madrid

Cheapest flights from Panama to Madrid
Explore the most affordable flight options available from Panama to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 25, 2025.

This Gotogate deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/279:30 pmPTY - MAD
Nonstop9h 35mAir Europa
vie. 12/123:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/25$670
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/72:55 amPTY - MAD
1 stop38h 25mAvianca
lun. 11/246:35 amMAD - PTY
1 stop13h 25mAvianca
Deal found 9/24$675
This Avianca deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/302:55 amPTY - MAD
1 stop14h 25mAvianca
sáb. 11/154:20 pmMAD - PTY
1 stop14h 40mAvianca
Deal found 9/25$678
This FlightHub deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/89:30 pmPTY - MAD
Nonstop9h 35mAir Europa
dom. 11/233:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/24$684
This Iberia deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/75:10 pmPTY - MAD
Nonstop10h 05mIberia
jue. 10/1612:00 pmMAD - PTY
Nonstop10h 40mIberia
Deal found 9/25$685
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/15:55 pmPTY - MAD
1 stop23h 25mAvianca
lun. 11/106:35 amMAD - PTY
1 stop24h 05mAvianca
Deal found 9/24$689
This Avianca deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/219:55 amPTY - MAD
1 stop18h 15mAvianca
jue. 11/66:35 amMAD - PTY
1 stop16h 20mAvianca
Deal found 9/25$702
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/252:55 amPTY - MAD
1 stop19h 40mAvianca
mar. 11/116:35 amMAD - PTY
1 stop13h 25mAvianca
Deal found 9/24$713
This KLM deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/136:45 pmPTY - MAD
1 stop18h 55mMultiple Airlines
jue. 11/276:00 amMAD - PTY
1 stop20h 10mMultiple Airlines
Deal found 9/25$718
This CheapOair deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/229:45 pmPTY - MAD
1 stop36h 40mTurkish Airlines
sáb. 11/296:20 amMAD - PTY
1 stop19h 30mTurkish Airlines
Deal found 9/24$719
This Booking.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/86:20 pmPTY - MAD
Nonstop10h 05mIberia
lun. 11/2411:40 amMAD - PTY
Nonstop11h 05mIberia
Deal found 9/24$720
This British Airways deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/65:10 pmPTY - MAD
Nonstop10h 05mIberia
jue. 10/2312:00 pmMAD - PTY
Nonstop10h 40mIberia
Deal found 9/24$725

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 25, 2025.
Use the filters below to find and compare flights from Panama to Madrid that are best for you.

Fly from

Panama

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

mié. 2/11

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

lun. 2/23

3:10 pm-7:45 pm

Nonstop10h 35m

$725

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

sáb. 10/25

5:10 pm-10:15 am

Nonstop10h 05m

Madrid Barajas

sáb. 11/8

11:40 am-4:45 pm

Nonstop11h 05m

$757

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

lun. 11/24

6:45 pm-11:25 pm

1 stop22h 40m

Madrid Barajas

mar. 12/2

8:05 pm-8:10 pm

1 stop30h 05m

$782

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

dom. 10/19

6:50 pm-9:30 am

1 stop31h 40m

Madrid Barajas

jue. 10/30

7:05 am-4:30 pm

1 stop15h 25m

$797

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

jue. 2/12

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

jue. 2/19

3:10 pm-7:45 pm

Nonstop10h 35m

$827

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

dom. 10/12

6:50 pm-11:25 pm

1 stop21h 35m

Madrid Barajas

mié. 11/12

6:00 am-8:10 pm

1 stop20h 10m

$829

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

lun. 10/13

6:50 pm-7:30 pm

1 stop17h 40m

Madrid Barajas

mié. 11/12

6:00 am-8:10 pm

1 stop20h 10m

$836

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

dom. 3/22

6:45 pm-4:25 pm

1 stop39h 40m

Madrid Barajas

mié. 4/1

6:25 pm-6:30 pm

2 stops31h 05m

$852

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

dom. 3/15

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

mié. 3/25

3:10 pm-7:45 pm

Nonstop10h 35m

$854

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

jue. 12/25

2:53 pm-8:30 pm

2 stops23h 37m

Madrid Barajas

mié. 3/4

11:40 am-4:45 pm

Nonstop11h 05m

$866

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/23

Showing 1-10 of 22 results
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Best time to book a flight from Panama to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Madrid

What is the cheapest month to book a flight from Panama to Madrid?

Currently, November is the cheapest month in which you can book a flight from Panama to Madrid (average of $543). Flying from Panama to Madrid in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MAD?

Find hourly flight availability from Panama to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 25, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama to Madrid at noon. If you’re flexible enough to do this you can expect to save up to 2% on your trip compared to booking a flight in the morning.

Weekly flight availability from Panama to Madrid

Explore weekly flight availability from Panama to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated septiembre 25, 2025.

The most flights from PA0 to MAD are scheduled on a Monday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated septiembre 25, 2025.
Get a feel of what it's like to fly with KLM, Air France, and Air Europa from Panama to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,390 reviews

Entertainment

7.1

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Food

7.3

Reviews

1 / 20
10.0
Excellent

Bobby,Sep 2025

EDI - ATL

Food was above average but could be better, The flight was operated by Delta and was excellent
KLM
7.8
Good
1,390 reviews
KLM
7.8
Good
1,390 reviews

Entertainment

7.1

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Food

7.3

Reviews

1 / 20
10.0
Excellent

Bobby,Sep 2025

EDI - ATL

Food was above average but could be better, The flight was operated by Delta and was excellent
Air France
7.4
Good
1,466 reviews
KLM
7.8
Good
1,390 reviews

Entertainment

7.1

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Food

7.3

Reviews

1 / 20
10.0
Excellent

Bobby,Sep 2025

EDI - ATL

Food was above average but could be better, The flight was operated by Delta and was excellent
Air Europa
7.0
Good
559 reviews
KLM
7.8
Good
1,390 reviews

Entertainment

7.1

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Food

7.3

Reviews

1 / 20
10.0
Excellent

Bobby,Sep 2025

EDI - ATL

Food was above average but could be better, The flight was operated by Delta and was excellent
Iberia
7.0
Good
2,955 reviews
KLM
7.8
Good
1,390 reviews

Entertainment

7.1

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Food

7.3

Reviews

1 / 20
10.0
Excellent

Bobby,Sep 2025

EDI - ATL

Food was above average but could be better, The flight was operated by Delta and was excellent
Avianca
6.7
Okay
2,442 reviews
KLM
7.8
Good
1,390 reviews

Entertainment

7.1

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Food

7.3

Reviews

1 / 20
10.0
Excellent

Bobby,Sep 2025

EDI - ATL

Food was above average but could be better, The flight was operated by Delta and was excellent

Related info for your journey

Find useful and relevant information for your journey from Panama to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Panama?

    Madrid Barajas (MAD), located 8.5 mi from the city center, is the airport you fly into when you book flights from Panama to Madrid.

  • How popular is this Panama to Madrid flight route?

    This flight path from Panama to Madrid Barajas was viewed by 16 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama to Madrid?

    For as low as $725, Air Europa can have you in Madrid from Panama in 9h 35m. Airlines will cover a distance of 5065 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from Panama to Madrid?

    Consider Air Europa (93%), Etihad Airways (93%) or China Eastern (93%) when booking your flight. These represent the most reliable airlines when flying from Panama to Madrid.

  • What are the cheapest flights from Panama to Madrid?

    On average you can expect to pay $742 for a flight from Panama to Madrid. The cheapest flight overall is $520 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $684.

  • Can I find deals for flights from Panama to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Madrid.

  • Can I find deals for business class flights from Panama to Madrid?

    Yes. Cheapflights offers flight deals from Panama to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Madrid?

    Currently, November is the cheapest month in which you can book a flight from Panama to Madrid (average of $543). Flying from Panama to Madrid in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Fuenlabrada
Getafe

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Top 8 airlines flying from Panama to Madrid

Discover the top 8 airlines that operate flights from Panama to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$604Average$777FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$659Average$790FlexibilityNo cancel feeOn-time83%
KLMCheapest$681Average$788FlexibilityNo cancel feeOn-time75%
IberiaCheapest$683Average$822FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$695Average$785FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$785FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$822FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$826Average$1,180FlexibilityNo cancel feeOn-time70%

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