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$435+ Cheap flights from Panama to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Panama to Madrid

Keep the following information in mind while searching for Panama to Madrid flight deals. Data was last updated June 12, 2025.

Round-trip from

$715
(Air France)

One-way from

$435
(Turkish Airlines)

Popular in

July

Cheapest in

March

Average price

$788

Good round-trip deal

$841 or less

Good one-way deal

$640 or less
From Panama to Madrid Barajas
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One-way flight from Panama to Madrid Barajas
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Highest demand for flights based on searches. 9% potential increase in price ($77 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Price to beat on a round-trip flight from Panama to Madrid Barajas.
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Price to beat on a one-way flight from Panama to Madrid Barajas.
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Find flight deals from Panama to Madrid

Cheapest flights from Panama to Madrid
Explore the most affordable flight options available from Panama to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Air France deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/37:55 pmPTY - MAD
1 stop13h 50mMultiple Airlines
Thu 8/215:10 pmMAD - PTY
1 stop30h 40mMultiple Airlines
Deal found 6/10$715
This Air France deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/37:55 pmPTY - MAD
1 stop13h 50mAir France
Thu 8/216:00 amMAD - PTY
1 stop18h 45mAir France
Deal found 6/12$716
This Air Europa deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/38:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Fri 8/223:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 6/10$724
This CheapOair deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/11:30 pmPTY - MAD
2 stops17h 55mAvianca
Sat 11/158:30 amMAD - PTY
2 stops34h 05mAvianca
Deal found 6/10$739
This Turkish Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/179:55 pmPTY - MAD
1 stop32h 40mTurkish Airlines
Tue 9/306:20 pmMAD - PTY
1 stop32h 40mTurkish Airlines
Deal found 6/10$740
This KLM deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/186:50 pmPTY - MAD
1 stop21h 35mKLM
Fri 8/298:25 pmMAD - PTY
1 stop27h 25mKLM
Deal found 6/10$749
This Booking.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:20 pmPTY - MAD
Nonstop10h 05mIberia
Sat 11/1511:45 amMAD - PTY
Nonstop11h 05mIberia
Deal found 6/10$778
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1010:55 pmPTY - MAD
2 stops24h 45mUnited Airlines
Fri 7/2510:50 amMAD - PTY
1 stop15h 41mUnited Airlines
Deal found 6/10$846

Cheapflights Fare Finder

Customize your flight search to find flights from Panama to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Panama to Madrid that are best for you.

Fly from

Panama

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 7/3

7:55 pm-4:45 pm

1 stop13h 50m

Madrid Barajas

Thu 8/21

5:10 pm-4:50 pm

1 stop30h 40m

$715

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 7/3

7:55 pm-4:45 pm

1 stop13h 50m

Madrid Barajas

Thu 8/21

6:00 am-5:45 pm

1 stop18h 45m

$716

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 8/3

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Sun 8/24

3:05 pm-6:40 pm

Nonstop10h 35m

$724

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 11/1

1:30 pm-1:25 pm

2 stops17h 55m

Madrid Barajas

Sat 11/15

8:30 am-12:35 pm

2 stops34h 05m

$739

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 10/24

9:55 pm-11:25 am

1 stop30h 30m

Madrid Barajas

Tue 11/11

11:55 am-7:50 pm

1 stop37h 55m

$740

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 7/18

6:50 pm-11:25 pm

1 stop21h 35m

Madrid Barajas

Fri 8/29

8:25 pm-4:50 pm

1 stop27h 25m

$749

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 11/3

6:20 pm-10:25 am

Nonstop10h 05m

Madrid Barajas

Sat 11/15

11:45 am-4:50 pm

Nonstop11h 05m

$778

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 7/10

10:55 pm-6:40 am

2 stops24h 45m

Madrid Barajas

Wed 7/23

10:50 am-7:31 pm

1 stop15h 41m

$846

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 9/21

9:55 pm-10:25 am

1 stop29h 30m

$435

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 7/14

10:05 pm-1:00 am

3 stops43h 55m

$460

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 16 results
1
2

Best time to book a flight from Panama to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Madrid

What is the cheapest month to book a flight from Panama to Madrid?

Currently, November is the cheapest month in which you can book a flight from Panama to Madrid (average of $543). Flying from Panama to Madrid in June is currently the most expensive (average of $1,057). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MAD?

Find hourly flight availability from Panama to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama to Madrid at noon. If you’re flexible enough to do this you can expect to save up to 5% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Panama to Madrid?

Use this chart to determine the cheapest time to fly round-trip from Panama to Madrid. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Panama to Madrid flight should consider departing on Tuesday evenings when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Panama to Madrid

Explore weekly flight availability from Panama to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 12, 2025.

The most flights from PA0 to MAD are scheduled on a Saturday (9 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (3 on average).

Rainfall in Madrid by month

Plan your trip to Madrid by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Madrid ranges from 0.4 - 2.4 inches per month. November is typically the wettest month, when rainfall can reach 2.4 in. July is typically the driest time to visit Madrid when rainfall is around 0.4 in.

Temperature in Madrid by month

Plan your trip to Madrid by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Madrid, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated June 12, 2025.
To help decide which airline to fly from Panama to Madrid, see what other customers have to say about KLM, Air France and Copa Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,358 reviews

Boarding

7.8

Comfort

7.7

Entertainment

7.1

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
KLM
7.8
Good
1,358 reviews
KLM
7.8
Good
1,358 reviews

Boarding

7.8

Comfort

7.7

Entertainment

7.1

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
Air France
7.5
Good
1,463 reviews
KLM
7.8
Good
1,358 reviews

Boarding

7.8

Comfort

7.7

Entertainment

7.1

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
Copa Airlines
7.5
Good
1,451 reviews
KLM
7.8
Good
1,358 reviews

Boarding

7.8

Comfort

7.7

Entertainment

7.1

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
United Airlines
7.4
Good
8,790 reviews
KLM
7.8
Good
1,358 reviews

Boarding

7.8

Comfort

7.7

Entertainment

7.1

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
Turkish Airlines
7.3
Good
3,848 reviews
KLM
7.8
Good
1,358 reviews

Boarding

7.8

Comfort

7.7

Entertainment

7.1

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.

Related info for your journey

Find useful and relevant information for your journey from Panama to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Panama?

    Madrid Barajas (MAD), located 8.5 mi from the city center, is the airport you fly into when you book flights from Panama to Madrid.

  • How popular is this Panama to Madrid flight route?

    This flight path from Panama to Madrid Barajas was viewed by 17 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Panama to Madrid one-way?

    $435 is the cheapest one-way deal found within the past few days, from Turkish Airlines. You may also be able to find cheap deals on KLM and Air Europa, with prices starting from $507 and $511, respectively.

  • What are the most reliable airlines from Panama to Madrid?

    Consider Air Europa (88%), Etihad Airways (88%) or China Eastern (88%) when booking your flight. These represent the most reliable airlines when flying from Panama to Madrid.

  • What are the cheapest flights from Panama to Madrid?

    On average you can expect to pay $1,574 for a flight from Panama to Madrid. The cheapest flight overall is $534 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $706.

  • Can I find deals for flights from Panama to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Madrid.

  • Can I find deals for business class flights from Panama to Madrid?

    Yes. Cheapflights offers flight deals from Panama to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Madrid?

    Currently, November is the cheapest month in which you can book a flight from Panama to Madrid (average of $543). Flying from Panama to Madrid in June is currently the most expensive (average of $1,057). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama?

Book flights to Panama if you plan to visit one of these locations
Segovia
Fuenlabrada

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Top 7 airlines flying from Panama to Madrid

Discover the top 7 airlines that operate flights from Panama to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$543Average$703FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$666Average$785FlexibilityNo cancel feeOn-time83%
KLMCheapest$670Average$798FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$678Average$813FlexibilityNo cancel feeOn-time69%
IberiaCheapest$680Average$831FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$681Average$763FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$729Average$800FlexibilityNo cancel feeOn-time77%

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