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$512+ Cheap flights from Panama to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/19. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
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Cheap flight deals from Panama to Madrid

Cheapest flights from Panama to Madrid
Explore the most affordable flight options available from Panama to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

This KLM deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:45 pmPTY - MAD
1 stop33h 30mMultiple Airlines
Mon 1/196:45 pmMAD - PTY
1 stop31h 25mMultiple Airlines
Deal found 12/26$911
This KLM deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:45 pmPTY - MAD
1 stop33h 30mKLM
Sat 1/31:05 pmMAD - PTY
1 stop33h 25mKLM
Deal found 12/27$926
This KLM deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:45 pmPTY - MAD
1 stop22h 40mKLM
Sun 1/184:50 pmMAD - PTY
1 stop29h 40mKLM
Deal found 12/25$948
This Expedia deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:20 pmPTY - MAD
Nonstop10h 05mIberia
Thu 1/153:50 pmMAD - PTY
2 stops51h 37mIberia
Deal found 12/26$963
This KLM deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:45 pmPTY - MAD
1 stop33h 30mMultiple Airlines
Wed 1/146:00 amMAD - PTY
1 stop20h 10mMultiple Airlines
Deal found 12/26$1,022
This KLM deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:45 pmPTY - MAD
1 stop33h 30mMultiple Airlines
Mon 1/1210:00 amMAD - PTY
1 stop16h 10mMultiple Airlines
Deal found 12/25$1,024
This Air France deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:20 pmPTY - MAD
1 stop18h 45mAir France
Sun 1/116:45 pmMAD - PTY
1 stop31h 25mAir France
Deal found 12/26$1,041
This Air France deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:20 pmPTY - MAD
1 stop18h 45mMultiple Airlines
Thu 1/156:00 amMAD - PTY
1 stop16h 30mMultiple Airlines
Deal found 12/26$1,044
This Air France deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:20 pmPTY - MAD
1 stop18h 45mAir France
Thu 1/156:45 pmMAD - PTY
1 stop31h 25mAir France
Deal found 12/27$1,068
This KLM deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:45 pmPTY - MAD
1 stop22h 40mKLM
Thu 1/156:00 amMAD - PTY
1 stop16h 30mKLM
Deal found 12/26$1,081
This Air Europa deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/261:56 pmPTY - MAD
1 stop15h 24mMultiple Airlines
Fri 1/303:10 pmMAD - PTY
Nonstop10h 35mMultiple Airlines
Deal found 12/26$1,086

Find flight deals from Panama to Madrid

Keep the following information in mind while searching for Panama to Madrid flight deals. Data was last updated December 28, 2025.

Most accurate provider

CheapOair
3 stars

Most trusted provider

CheapOair
3 stars

Round-trip from

$710
(Gotogate)

One-way from

$512
(Kiwi.com)

Popular in

December

Cheapest in

March

Average price

$928

Good round-trip deal

$773 or less

Good one-way deal

$657 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Madrid Barajas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Madrid Barajas flights.
Search Deals
From Panama to Madrid Barajas
Search Deals
One-way flight from Panama to Madrid Barajas
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($47 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Panama to Madrid Barajas.
Search Deals
Price to beat on a one-way flight from Panama to Madrid Barajas.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Panama to Madrid that are best for you.

Fly from

Panama

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 3/11

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Mon 3/23

11:55 am-5:05 pm

2 stops35h 10m

$739

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 4/29

10:20 pm-1:35 pm

1 stop32h 15m

Madrid Barajas

Sat 5/16

7:30 am-6:25 pm

2 stops41h 55m

$739

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 3/25

9:45 pm-4:25 pm

1 stop36h 40m

Madrid Barajas

Tue 3/31

7:30 am-6:25 pm

2 stops41h 55m

$748

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/8

9:30 pm-2:20 pm

Nonstop9h 50m

Madrid Barajas

Wed 5/13

3:55 pm-8:00 pm

Nonstop11h 05m

$757

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 4/15

10:20 pm-4:55 pm

1 stop35h 35m

Madrid Barajas

Wed 4/29

2:40 pm-6:30 pm

2 stops34h 50m

$761

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 2/22

6:45 pm-1:20 pm

1 stop36h 35m

Madrid Barajas

Fri 3/13

5:55 pm-7:50 pm

1 stop31h 55m

$761

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 3/17

6:45 pm-11:30 pm

1 stop22h 45m

Madrid Barajas

Sat 4/11

12:00 pm-6:25 pm

2 stops37h 25m

$773

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/2

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Mon 2/16

11:55 am-5:05 pm

2 stops35h 10m

$792

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 3/8

6:45 pm-11:30 pm

1 stop22h 45m

Madrid Barajas

Sat 3/14

2:25 pm-5:05 pm

2 stops32h 40m

$803

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/29

6:50 pm-11:25 pm

1 stop21h 35m

Madrid Barajas

Sat 6/6

6:00 am-4:50 pm

2 stops17h 50m

$813

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/26

Showing 1-10 of 21 results
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Best time to book a flight from Panama to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Madrid

What is the cheapest month to book a flight from Panama to Madrid?

Currently, April is the cheapest month in which you can book a flight from Panama to Madrid (average of $595). Flying from Panama to Madrid in July is currently the most expensive (average of $711). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MAD?

Find hourly flight availability from Panama to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 28, 2025.

When flying from Panama to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Panama to Madrid

Explore weekly flight availability from Panama to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 28, 2025.

The most flights from PA0 to MAD are scheduled on a Monday (10 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (3 on average).

How often are flights from Panama to Madrid delayed?

About 14% of weekly flights between Panama and Madrid have experienced delays in the past year, with the average delay time being 133 minutes.

What is the most punctual flight time for Panama to Madrid flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Monday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama to Madrid flights?

Over the last year, Pascan have had the lowest number of delays on this route, with just 6% of flights being delayed.

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated December 28, 2025.
Get a feel of what it's like to fly with Copa Airlines, Air France, and Air Europa from Panama to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Entertainment

6.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Entertainment

6.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Air France
7.4
Good
1,515 reviews
Copa Airlines
7.6
Good
1,561 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Entertainment

6.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Air Europa
7.0
Good
577 reviews
Copa Airlines
7.6
Good
1,561 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Entertainment

6.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Iberia
7.0
Good
3,059 reviews
Copa Airlines
7.6
Good
1,561 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Entertainment

6.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,489 reviews
Copa Airlines
7.6
Good
1,561 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Entertainment

6.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Panama?

    Madrid Barajas (MAD), located 8.5 mi from the city center, is the airport you fly into when you book flights from Panama to Madrid.

  • How popular is this Panama to Madrid flight route?

    This flight path from Panama to Madrid Barajas was viewed by 20 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama to Madrid?

    For as low as $757, Turkish Airlines can have you in Madrid from Panama in 9h 50m. Airlines will cover a distance of 5065 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Panama to Madrid one-way?

    $434 is the cheapest one-way deal found within the past few days, from Turkish Airlines. You may also be able to find cheap deals on Air Europa and Avianca, with prices starting from $510 and $541, respectively.

  • What are the most reliable airlines from Panama to Madrid?

    Consider Qatar Airways (81%), Iberia (81%) or EL AL (81%) when booking your flight. These represent the most reliable airlines when flying from Panama to Madrid.

  • What are the cheapest flights from Panama to Madrid?

    On average you can expect to pay $1,559 for a flight from Panama to Madrid. The cheapest flight overall is $603 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $655.

  • Can I find deals for flights from Panama to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Madrid.

  • Can I find deals for business class flights from Panama to Madrid?

    Yes. Cheapflights offers flight deals from Panama to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Madrid?

    Currently, April is the cheapest month in which you can book a flight from Panama to Madrid (average of $595). Flying from Panama to Madrid in July is currently the most expensive (average of $711). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Getafe

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Top 7 airlines flying from Panama to Madrid

Discover the top 7 airlines that operate flights from Panama to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$614Average$734FlexibilityNo cancel feeOn-time71%
KLMCheapest$654Average$763FlexibilityNo cancel feeOn-time75%
Air EuropaCheapest$665Average$825FlexibilityNo cancel feeOn-time83%
IberiaCheapest$677Average$831FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$695Average$782FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$762FlexibilityNo cancel feeOn-time77%
Copa AirlinesCheapest$728Average$1,274FlexibilityNo cancel feeOn-time70%

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