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$538+ Cheap flights from Panama to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Apr 27 — May 41
Mon 4/27
Mon 5/4
1 adult, Economy
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Cheap flight deals from Panama to Madrid

Cheapest flights from Panama to Madrid
Explore the most affordable flight options available from Panama to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.

This Air France deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:27 pm
PTY
-
MAD
1 stop14h 48m
Air France
Sun 5/315:45 pm
MAD
-
PTY
1 stop33h 20m
Air France
Deal found 3/25$678
This Avianca deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/252:55 pm
PTY
-
MAD
1 stop16h 30m
Avianca
Sat 10/316:40 am
MAD
-
PTY
1 stop16h 15m
Avianca
Deal found 3/25$682
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:45 am
PTY
-
MAD
1 stop12h 50m
Avianca
Sun 11/86:35 am
MAD
-
PTY
1 stop13h 25m
Avianca
Deal found 3/25$683
This Air France deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:27 pm
PTY
-
MAD
1 stop14h 48m
Multiple Airlines
Tue 5/198:30 pm
MAD
-
PTY
1 stop27h 20m
Multiple Airlines
Deal found 3/23$686
This Air France deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:27 pm
PTY
-
MAD
1 stop14h 48m
Multiple Airlines
Fri 5/158:30 pm
MAD
-
PTY
1 stop27h 20m
Multiple Airlines
Deal found 3/25$687
This Air France deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:27 pm
PTY
-
MAD
2 stops19h 18m
Multiple Airlines
Sat 5/161:05 pm
MAD
-
PTY
1 stop34h 45m
Multiple Airlines
Deal found 3/24$698
This Avianca deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:10 am
PTY
-
MAD
1 stop15h 55m
Avianca
Thu 10/296:35 am
MAD
-
PTY
1 stop16h 20m
Avianca
Deal found 3/26$705
This Air France deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:27 pm
PTY
-
MAD
1 stop14h 48m
Air France
Tue 5/196:00 am
MAD
-
PTY
2 stops17h 50m
Air France
Deal found 3/24$709
This Air France deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:27 pm
PTY
-
MAD
2 stops19h 18m
Air France
Wed 5/136:00 am
MAD
-
PTY
2 stops17h 50m
Air France
Deal found 3/24$720
This Air France deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:27 pm
PTY
-
MAD
1 stop14h 48m
Air France
Sat 5/308:15 pm
MAD
-
PTY
1 stop31h 05m
Air France
Deal found 3/24$721

Find flight deals from Panama to Madrid

Keep the following information in mind while searching for Panama to Madrid flight deals. Data was last updated March 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$678
(Air France)

One-way from

$538
(Mytrip)

Popular in

December

Cheapest in

February

Average price

$780

Good round-trip deal

$773 or less

Good one-way deal

$682 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Madrid Barajas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Madrid Barajas flights.
Search Deals
From Panama to Madrid Barajas
Search Deals
One-way flight from Panama to Madrid Barajas
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($34 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Panama to Madrid Barajas.
Search Deals
Price to beat on a one-way flight from Panama to Madrid Barajas.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from Panama to Madrid that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 4/28

3:30 pm-8:05 am

2 stops33h 35m

Madrid Barajas

Tue 6/2

12:45 pm-7:31 pm

2 stops37h 46m

$852
Quickest round-trip

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 5/7

9:45 am-9:00 am

1 stop16h 15m

Madrid Barajas

Thu 5/21

10:50 am-7:31 pm

1 stop15h 41m

$853

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 6/11

3:30 pm-8:50 am

2 stops34h 20m

Madrid Barajas

Wed 6/24

11:15 am-6:37 pm

2 stops38h 22m

$856

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 9/23

9:45 am-9:00 am

1 stop16h 15m

Madrid Barajas

Thu 10/8

11:15 am-2:14 pm

2 stops33h 59m

$857

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 9/16

9:45 am-6:50 am

2 stops38h 05m

Madrid Barajas

Tue 9/29

11:15 am-2:14 pm

2 stops33h 59m

$860

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 4/20

9:45 am-6:50 am

2 stops38h 05m

Madrid Barajas

Wed 5/20

11:15 am-4:12 pm

2 stops35h 57m

$860

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 9/22

9:45 am-9:00 am

1 stop16h 15m

Madrid Barajas

Sun 10/4

1:30 pm-6:37 pm

2 stops36h 07m

$861

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 4/29

3:30 pm-8:05 am

2 stops33h 35m

Madrid Barajas

Sat 5/16

11:15 am-4:12 pm

2 stops35h 57m

$861

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/29

9:45 am-11:50 am

2 stops19h 05m

Madrid Barajas

Sun 6/7

10:50 am-7:31 pm

1 stop15h 41m

$880

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 6/2

9:45 am-4:45 pm

2 stops24h 00m

Madrid Barajas

Thu 6/11

10:50 am-7:31 pm

1 stop15h 41m

$880

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/26

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Best time to book a flight from Panama to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Madrid

What is the cheapest month to book a flight from Panama to Madrid?

Currently, May is the cheapest month in which you can book a flight from Panama to Madrid (average of $614). Flying from Panama to Madrid in July is currently the most expensive (average of $717). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MAD?

Find hourly flight availability from Panama to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2026.

When flying from Panama to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How often are flights from Panama to Madrid delayed?

About 13% of weekly flights between Panama and Madrid have experienced delays in the past year, with the average delay time being 152 minutes.

What is the most punctual flight time for Panama to Madrid flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Sunday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama to Madrid flights?

Over the last year, Air Europa have had the lowest number of delays on this route, with just 11% of flights being delayed.

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated March 28, 2026.
Get a feel of what it's like to fly with Copa Airlines,Air France, andIberia from Panama to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,577 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.5

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,577 reviews
Copa Airlines
7.5
Good
1,577 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.5

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Air France
7.4
Good
1,555 reviews
Copa Airlines
7.5
Good
1,577 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.5

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Iberia
7.0
Good
3,158 reviews
Copa Airlines
7.5
Good
1,577 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.5

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Air Europa
6.9
Okay
597 reviews
Copa Airlines
7.5
Good
1,577 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.5

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Avianca
6.5
Okay
2,506 reviews
Copa Airlines
7.5
Good
1,577 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.5

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from Panama to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Panama?

    Madrid Barajas (MAD), located 8.5 mi from the city center, is the airport you fly into when you book flights from Panama to Madrid.

  • How popular is this Panama to Madrid flight route?

    This flight path from Panama to Madrid Barajas was viewed by 25 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama to Madrid?

    For as low as $852, United Airlines can have you in Madrid from Panama in 33h 35m. Airlines will cover a distance of 5065 mi.

  • What are the cheapest airlines to fly from Panama to Madrid one-way?

    $434 is the cheapest one-way deal found within the past few days, from Turkish Airlines. You may also be able to find cheap deals on Avianca and Air Europa, with prices starting from $508 and $518, respectively.

  • What are the most reliable airlines from Panama to Madrid?

    Consider Air Europa (87%), Etihad Airways (87%) or China Eastern (87%) when booking your flight. These represent the most reliable airlines when flying from Panama to Madrid.

  • What are the cheapest flights from Panama to Madrid?

    On average you can expect to pay $1,444 for a flight from Panama to Madrid. The cheapest flight overall is $586 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $726.

  • Can I find deals for flights from Panama to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Madrid.

  • Can I find deals for business class flights from Panama to Madrid?

    Yes. Cheapflights offers flight deals from Panama to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Madrid?

    Currently, May is the cheapest month in which you can book a flight from Panama to Madrid (average of $614). Flying from Panama to Madrid in July is currently the most expensive (average of $717). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Getafe

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Alternative routes for Panama to Madrid

See prices for flight routes from nearby airports that may be better suited for you.
San José to Madrid flights
Panama City to Madrid flights
San Salvador to Madrid flights
Guatemala City to Madrid flights
Managua to Madrid flights
San Pedro Sula to Madrid flights

Top 8 airlines flying from Panama to Madrid

Discover the top 8 airlines that operate flights from Panama to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$618Average$795FlexibilityNo cancel feeOn-time75%
AviancaCheapest$635Average$734FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$674Average$852FlexibilityNo cancel feeOn-time83%
IberiaCheapest$677Average$857FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$685Average$776FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$762FlexibilityNo cancel feeOn-time77%
Copa AirlinesCheapest$722Average$1,269FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$848Average$953FlexibilityNo cancel feeOn-time69%

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