$487+ Cheap flights from Panama to Madrid, Spain (MAD)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Mar 14 — Mar 211
1 adult, Economy
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Cheapest flights from Panama to MadridExplore the most affordable flight options available from Panama to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
Explore the most affordable flight options available from Panama to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
This KLM deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:45 pm
PTY
- MAD
1 stop33h 30m
KLM
Sun 2/154:50 pm
MAD
- PTY
1 stop33h 05m
KLM
Deal found 2/9![KLM logo]()
$641
This KLM deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:50 pm
PTY
- MAD
1 stop31h 40m
Multiple Airlines
Thu 6/255:45 pm
MAD
- PTY
1 stop33h 00m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$643
This Air France deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:27 pm
PTY
- MAD
1 stop14h 48m
Multiple Airlines
Fri 5/158:30 pm
MAD
- PTY
1 stop27h 20m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$644
This Air France deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/169:55 pm
PTY
- MAD
1 stop18h 20m
Air France
Thu 6/254:40 pm
MAD
- PTY
1 stop34h 05m
Air France
Deal found 2/11![Air France logo]()
$645
This KLM deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:50 pm
PTY
- MAD
1 stop14h 35m
Multiple Airlines
Wed 6/174:40 pm
MAD
- PTY
1 stop34h 05m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$647
This KLM deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:50 pm
PTY
- MAD
1 stop21h 35m
Multiple Airlines
Fri 6/196:00 am
MAD
- PTY
1 stop20h 45m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$648
This Air France deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:27 pm
PTY
- MAD
1 stop14h 48m
Air France
Tue 5/196:00 am
MAD
- PTY
2 stops17h 50m
Air France
Deal found 2/9![Air France logo]()
$650
This Air France deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:20 pm
PTY
- MAD
1 stop14h 55m
Air France
Thu 5/216:00 am
MAD
- PTY
2 stops17h 50m
Air France
Deal found 2/11![Air France logo]()
$651
This Air France deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/62:28 pm
PTY
- MAD
1 stop14h 47m
Air France
Sat 4/118:15 pm
MAD
- PTY
1 stop30h 30m
Air France
Deal found 2/11![Air France logo]()
$657
This Air France deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/249:55 pm
PTY
- MAD
1 stop28h 15m
Air France
Mon 6/16:00 am
MAD
- PTY
1 stop20h 45m
Air France
Deal found 2/9![Air France logo]()
$658
This Gotogate deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:25 pm
PTY
- MAD
Nonstop9h 50m
Air Europa
Tue 5/193:05 pm
MAD
- PTY
Nonstop10h 35m
Air Europa
Deal found 2/9![Air Europa logo]()
$659
Best flights from Panama to MadridDiscover carefully curated flight deals from Panama to Madrid that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
Discover carefully curated flight deals from Panama to Madrid that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
This KLM deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:50 pm
PTY
- MAD
1 stop34h 20m
Multiple Airlines
Thu 6/258:15 pm
MAD
- PTY
1 stop30h 30m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$644
This KLM deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:50 pm
PTY
- MAD
1 stop35h 50m
KLM
Wed 5/276:00 am
MAD
- PTY
1 stop17h 50m
KLM
Deal found 2/8![KLM logo]()
$668
This Air Europa deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/28:25 pm
PTY
- MAD
Nonstop9h 50m
Air Europa
Sat 6/203:05 pm
MAD
- PTY
Nonstop10h 35m
Air Europa
Deal found 2/11![Air Europa logo]()
$727
This British Airways deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:20 pm
PTY
- MAD
Nonstop10h 05m
Iberia
Sun 3/294:00 pm
MAD
- PTY
Nonstop11h 00m
Iberia
Deal found 2/11![Iberia logo]()
$791
This Turkish Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2710:20 pm
PTY
- MAD
1 stop29h 10m
Turkish Airlines
Sun 5/107:30 am
MAD
- PTY
2 stops42h 00m
Turkish Airlines
Deal found 2/9![Turkish Airlines logo]()
$801
This Air Europa deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:25 pm
PTY
- MAD
Nonstop9h 50m
Air Europa
Sun 5/103:05 pm
MAD
- PTY
Nonstop10h 35m
Air Europa
Deal found 2/9![Air Europa logo]()
$727
This KLM deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:50 pm
PTY
- MAD
1 stop31h 40m
KLM
Mon 6/18:30 pm
MAD
- PTY
1 stop27h 20m
KLM
Deal found 2/10![KLM logo]()
$777
This Air Europa deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/59:30 pm
PTY
- MAD
Nonstop9h 35m
Air Europa
Sun 3/83:10 pm
MAD
- PTY
Nonstop10h 35m
Air Europa
Deal found 2/11![Air Europa logo]()
$781
This Air Europa deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:25 pm
PTY
- MAD
Nonstop9h 50m
Air Europa
Sat 6/203:05 pm
MAD
- PTY
Nonstop10h 35m
Air Europa
Deal found 2/11![Air Europa logo]()
$791
This Air Europa deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:25 pm
PTY
- MAD
Nonstop9h 50m
Air Europa
Fri 6/193:05 pm
MAD
- PTY
Nonstop10h 35m
Air Europa
Deal found 2/11![Air Europa logo]()
$791
This Air Europa deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:25 pm
PTY
- MAD
Nonstop9h 50m
Air Europa
Fri 6/193:05 pm
MAD
- PTY
Nonstop10h 35m
Air Europa
Deal found 2/11![Air Europa logo]()
$791
Last-minute flights from Panama to MadridDiscover last-minute flight deals from Panama to Madrid. Data last updated February 12, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to Madrid. Data last updated February 12, 2026 and is based on user searches.
This KLM deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1810:05 pm
PTY
- MAD
1 stop33h 35m
KLM
Wed 2/251:05 pm
MAD
- PTY
1 stop33h 25m
KLM
Deal found 2/11![KLM logo]()
$680
This KLM deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1810:05 pm
PTY
- MAD
1 stop33h 35m
KLM
Tue 5/128:30 pm
MAD
- PTY
1 stop27h 20m
KLM
Deal found 2/10![KLM logo]()
$681
This KLM deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1810:05 pm
PTY
- MAD
1 stop33h 35m
KLM
Thu 5/145:20 pm
MAD
- PTY
1 stop30h 30m
KLM
Deal found 2/11![KLM logo]()
$682
This KLM deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1810:05 pm
PTY
- MAD
1 stop33h 35m
Multiple Airlines
Sat 3/76:45 pm
MAD
- PTY
1 stop31h 25m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$694
This KLM deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1810:05 pm
PTY
- MAD
1 stop33h 35m
Multiple Airlines
Tue 5/126:00 am
MAD
- PTY
2 stops17h 50m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$702
This Avianca deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/29:45 am
PTY
- MAD
1 stop12h 50m
Avianca
Mon 3/166:35 am
MAD
- PTY
1 stop13h 25m
Avianca
Deal found 2/9![Avianca logo]()
$678
This Gotogate deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/179:30 pm
PTY
- MAD
Nonstop9h 35m
Air Europa
Mon 3/233:10 pm
MAD
- PTY
Nonstop10h 35m
Air Europa
Deal found 2/10![Air Europa logo]()
$684
This deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/182:55 am
PTY
- MAD
1 stop14h 25m
Avianca
Thu 3/261:20 am
MAD
- PTY
1 stop13h 30m
Avianca
Deal found 2/9![Avianca logo]()
$651
This Air Europa deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/259:30 pm
PTY
- MAD
Nonstop9h 35m
Air Europa
Fri 5/293:05 pm
MAD
- PTY
Nonstop10h 35m
Air Europa
Deal found 2/11![Air Europa logo]()
$700
This Air France deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/302:28 pm
PTY
- MAD
1 stop14h 47m
Multiple Airlines
Wed 4/156:00 am
MAD
- PTY
1 stop17h 50m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$644
One-way flights from Panama to MadridSearch for one-way flight options from Panama to Madrid. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
Search for one-way flight options from Panama to Madrid. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/99:45 am
PTY
- MAD
3 stops49h 20m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/69:34 am
PTY
- MAD
3 stops26h 36m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$509
This Avianca deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/92:55 am
PTY
- MAD
1 stop14h 25m
Avianca
Deal found 2/9![Avianca logo]()
$518
This Avianca deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/62:55 am
PTY
- MAD
1 stop14h 25m
Avianca
Deal found 2/9![Avianca logo]()
$519
This Avianca deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/132:55 pm
PTY
- MAD
1 stop26h 25m
Avianca
Deal found 2/10![Avianca logo]()
$522
This Mytrip deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/172:55 am
PTY
- MAD
3 stops32h 15m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$533
This FlightHub deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/73:55 am
PTY
- MAD
1 stop18h 40m
Avianca
Deal found 2/9![Avianca logo]()
$539
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/85:50 pm
PTY
- MAD
3 stops42h 10m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$544
This FlightHub deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:25 am
PTY
- MAD
1 stop13h 55m
Avianca
Deal found 2/10![Avianca logo]()
$548
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:50 pm
PTY
- MAD
3 stops42h 15m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$562
This Mytrip deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:10 am
PTY
- MAD
3 stops26h 00m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$563
Find flight deals from Panama to Madrid
Keep the following information in mind while searching for Panama to Madrid flight deals. Data was last updated February 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $643 (KLM) |
One-way from | $487 (Kiwi.com) |
Popular in | December |
Cheapest in | May |
Average price | $732 |
Good round-trip deal | $726 or less |
Good one-way deal | $846 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Panama to Madrid that are best for you.
Fly from
Panama
Fly to
Madrid
Route
Depart
Return
Price
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Tue 6/16
6:50 pm-12:10 pm
1 stop34h 20m
Madrid Barajas
Thu 6/25
8:15 pm-7:45 pm
1 stop30h 30m
$644
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Wed 5/20
6:50 pm-1:40 pm
1 stop35h 50m
Madrid Barajas
Wed 5/27
6:00 am-4:50 pm
1 stop17h 50m
$668
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Tue 6/2
8:25 pm-1:15 pm
Nonstop9h 50m
Madrid Barajas
Sat 6/20
3:05 pm-6:40 pm
Nonstop10h 35m
$727
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Mon 4/27
8:25 pm-1:15 pm
Nonstop9h 50m
Madrid Barajas
Sun 5/10
3:05 pm-6:40 pm
Nonstop10h 35m
$727
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Sun 5/24
6:50 pm-9:30 am
1 stop31h 40m
Madrid Barajas
Mon 6/1
8:30 pm-4:50 pm
1 stop27h 20m
$777
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Thu 3/5
9:30 pm-1:05 pm
Nonstop9h 35m
Madrid Barajas
Sun 3/8
3:10 pm-7:45 pm
Nonstop10h 35m
$781
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Mon 3/16
6:20 pm-10:25 am
Nonstop10h 05m
Madrid Barajas
Sun 3/29
4:00 pm-8:00 pm
Nonstop11h 00m
$791
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Sun 5/31
8:25 pm-1:15 pm
Nonstop9h 50m
Madrid Barajas
Sat 6/20
3:05 pm-6:40 pm
Nonstop10h 35m
$791
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Sat 5/30
8:25 pm-1:15 pm
Nonstop9h 50m
Madrid Barajas
Fri 6/19
3:05 pm-6:40 pm
Nonstop10h 35m
$791
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Thu 6/4
8:25 pm-1:15 pm
Nonstop9h 50m
Madrid Barajas
Fri 6/19
3:05 pm-6:40 pm
Nonstop10h 35m
$791
Showing 1-10 of 21 results
Best time to book a flight from Panama to Madrid
Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama with our price prediction graph.
PTY-MAD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to Madrid
PA0-MAD
PTY-MAD
What is the cheapest month to book a flight from Panama to Madrid?
Currently, May is the cheapest month in which you can book a flight from Panama to Madrid (average of $608). Flying from Panama to Madrid in July is currently the most expensive (average of $716). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to MAD?
Find hourly flight availability from Panama to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 12, 2026.
When flying from Panama to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Weekly flight availability from Panama to Madrid
Explore weekly flight availability from Panama to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 12, 2026.
The most flights from PA0 to MAD are scheduled on a Monday (10 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (4 on average).
How often are flights from Panama to Madrid delayed?
About 12% of weekly flights between Panama and Madrid have experienced delays in the past year, with the average delay time being 140 minutes.
What is the most punctual flight time for Panama to Madrid flights?
Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Sunday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama to Madrid flights?
Over the last year, Pascan have had the lowest number of delays on this route, with just 6% of flights being delayed.
Reviews of airlines servicing Madrid
Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated February 12, 2026.
Get a feel of what it's like to fly with Copa Airlines, Air France, and Iberia from Panama to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Comfort
7.4
Food
6.8
Overall
7.5
Crew
8.1
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Comfort
7.4
Food
6.8
Overall
7.5
Crew
8.1
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Comfort
7.4
Food
6.8
Overall
7.5
Crew
8.1
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Comfort
7.4
Food
6.8
Overall
7.5
Crew
8.1
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Comfort
7.4
Food
6.8
Overall
7.5
Crew
8.1
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Comfort
7.4
Food
6.8
Overall
7.5
Crew
8.1
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Madrid?
Book flights to Madrid if you plan to visit one of these locationsGetafe
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Complete your trip
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Search flights from Panama to Madrid by cabin class
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Other flights to Madrid
Explore flights to Madrid departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 12, 2026.
Panama and Madrid flights
Browse other Panama and Madrid flight options. Last updated on February 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 8 airlines flying from Panama to Madrid
Discover the top 8 airlines that operate flights from Panama to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$623 | Average$742 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$654 | Average$763 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$670 | Average$837 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$672 | Average$841 | FlexibilityNo cancel fee | On-time83% | |
| Cheapest$694 | Average$783 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$698 | Average$762 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$722 | Average$1,269 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$823 | Average$953 | FlexibilityNo cancel fee | On-time69% |