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$500+ Cheap flights from Panama to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/17. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Dec 12 — Dec 191
Fri 12/12
Fri 12/19
1 adult, Economy
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Find flight deals from Panama to Madrid

Cheapest flights from Panama to Madrid
Explore the most affordable flight options available from Panama to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

This Turkish Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/229:45 pmPTY - MAD
1 stop31h 05mTurkish Airlines
Sat 2/146:20 amMAD - PTY
1 stop19h 30mTurkish Airlines
Deal found 11/10$729
This Air France deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:20 pmPTY - MAD
1 stop28h 50mMultiple Airlines
Wed 1/216:00 amMAD - PTY
1 stop16h 30mMultiple Airlines
Deal found 11/11$731
This Turkish Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:45 pmPTY - MAD
1 stop34h 05mTurkish Airlines
Tue 11/182:25 pmMAD - PTY
1 stop35h 25mTurkish Airlines
Deal found 11/10$738
This British Airways deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/226:20 pmPTY - MAD
Nonstop10h 05mIberia
Sat 2/1411:40 amMAD - PTY
Nonstop11h 05mIberia
Deal found 11/10$742
This Air France deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:20 pmPTY - MAD
1 stop14h 50mMultiple Airlines
Sat 1/246:00 amMAD - PTY
1 stop19h 55mMultiple Airlines
Deal found 11/9$753
This Air Europa deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Fri 3/133:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/12$757
This Turkish Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/229:45 pmPTY - MAD
1 stop31h 05mTurkish Airlines
Mon 12/82:25 pmMAD - PTY
2 stops32h 40mTurkish Airlines
Deal found 11/11$764
This KLM deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:45 pmPTY - MAD
1 stop15h 20mKLM
Wed 1/147:05 amMAD - PTY
1 stop18h 50mKLM
Deal found 11/11$775
This FlightHub deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Wed 3/43:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/11$778

Cheap flight deals from Panama to Madrid

Keep the following information in mind while searching for Panama to Madrid flight deals. Data was last updated November 12, 2025.

Most accurate provider

Gotogate
3 stars

Most trusted provider

Gotogate
3 stars

Round-trip from

$678
(KLM)

One-way from

$500
(Kiwi.com)

Popular in

December

Cheapest in

March

Average price

$745

Good round-trip deal

$810 or less

Good one-way deal

$635 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Madrid Barajas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Madrid Barajas flights.
Search Deals
From Panama to Madrid Barajas
Search Deals
One-way flight from Panama to Madrid Barajas
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Panama to Madrid Barajas.
Search Deals
Price to beat on a one-way flight from Panama to Madrid Barajas.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
Use the filters below to find and compare flights from Panama to Madrid that are best for you.

Fly from

Panama

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 5/3

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Fri 5/8

3:05 pm-6:40 pm

Nonstop10h 35m

$725

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 2/28

9:45 pm-10:50 am

1 stop31h 05m

Madrid Barajas

Tue 3/31

6:25 pm-8:20 pm

1 stop32h 55m

$725

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 5/2

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Fri 5/8

3:05 pm-6:40 pm

Nonstop10h 35m

$725

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 3/16

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Sun 3/29

2:40 pm-6:30 pm

2 stops34h 50m

$738

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 3/22

6:45 pm-4:25 pm

1 stop39h 40m

Madrid Barajas

Wed 4/1

7:30 am-8:20 pm

1 stop19h 50m

$738

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 3/14

9:45 pm-4:25 pm

1 stop36h 40m

Madrid Barajas

Sun 3/22

2:25 pm-5:05 pm

2 stops32h 40m

$738

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 3/17

6:45 pm-4:25 pm

1 stop39h 40m

Madrid Barajas

Sat 4/11

6:25 pm-6:30 pm

2 stops31h 05m

$750

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 3/30

10:55 pm-6:40 am

2 stops24h 45m

Madrid Barajas

Wed 4/15

12:45 pm-4:04 am

2 stops22h 19m

$851

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 3/1

4:41 pm-8:00 am

2 stops33h 19m

Madrid Barajas

Sun 3/8

1:45 pm-6:38 pm

2 stops58h 53m

$891

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 4/16

7:55 am-4:20 pm

2 stops25h 25m

Madrid Barajas

Thu 4/23

11:15 am-6:37 pm

2 stops38h 22m

$892

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 22 results
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Best time to book a flight from Panama to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Madrid

What is the cheapest month to book a flight from Panama to Madrid?

Currently, March is the cheapest month in which you can book a flight from Panama to Madrid (average of $595). Flying from Panama to Madrid in July is currently the most expensive (average of $708). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MAD?

Find hourly flight availability from Panama to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 12, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama to Madrid in the morning. If you’re flexible enough to do this you can expect to save up to 18% on your trip compared to booking a flight at noon.

Weekly flight availability from Panama to Madrid

Explore weekly flight availability from Panama to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 12, 2025.

The most flights from PA0 to MAD are scheduled on a Monday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated November 12, 2025.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Air Europa from Panama to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,486 reviews

Food

7.0

Comfort

7.4

Boarding

7.4

Crew

8.2

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Air France
7.4
Good
1,486 reviews
Air France
7.4
Good
1,486 reviews

Food

7.0

Comfort

7.4

Boarding

7.4

Crew

8.2

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Turkish Airlines
7.3
Good
4,043 reviews
Air France
7.4
Good
1,486 reviews

Food

7.0

Comfort

7.4

Boarding

7.4

Crew

8.2

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Air Europa
7.0
Good
569 reviews
Air France
7.4
Good
1,486 reviews

Food

7.0

Comfort

7.4

Boarding

7.4

Crew

8.2

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Iberia
7.0
Good
3,009 reviews
Air France
7.4
Good
1,486 reviews

Food

7.0

Comfort

7.4

Boarding

7.4

Crew

8.2

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Avianca
6.6
Okay
2,473 reviews
Air France
7.4
Good
1,486 reviews

Food

7.0

Comfort

7.4

Boarding

7.4

Crew

8.2

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.

Related info for your journey

Find useful and relevant information for your journey from Panama to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Panama?

    Madrid Barajas (MAD), located 8.5 mi from the city center, is the airport you fly into when you book flights from Panama to Madrid.

  • How popular is this Panama to Madrid flight route?

    This flight path from Panama to Madrid Barajas was viewed by 19 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama to Madrid?

    For as low as $725, Air Europa can have you in Madrid from Panama in 9h 50m. Airlines will cover a distance of 5065 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from Panama to Madrid?

    Consider Air Europa (89%), Etihad Airways (89%) or China Eastern (89%) when booking your flight. These represent the most reliable airlines when flying from Panama to Madrid.

  • What are the cheapest flights from Panama to Madrid?

    On average you can expect to pay $858 for a flight from Panama to Madrid. The cheapest flight overall is $526 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $663.

  • Can I find deals for flights from Panama to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Madrid.

  • Can I find deals for business class flights from Panama to Madrid?

    Yes. Cheapflights offers flight deals from Panama to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Madrid?

    Currently, March is the cheapest month in which you can book a flight from Panama to Madrid (average of $595). Flying from Panama to Madrid in July is currently the most expensive (average of $708). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Getafe

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Top 8 airlines flying from Panama to Madrid

Discover the top 8 airlines that operate flights from Panama to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$614Average$736FlexibilityNo cancel feeOn-time71%
KLMCheapest$654Average$786FlexibilityNo cancel feeOn-time75%
Air EuropaCheapest$661Average$805FlexibilityNo cancel feeOn-time83%
IberiaCheapest$677Average$828FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$697Average$786FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$768FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$822FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$728Average$1,232FlexibilityNo cancel feeOn-time70%

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