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$449+ Cheap flights from Panama to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Panama to Madrid

Keep the following information in mind while searching for Panama to Madrid flight deals. Data was last updated August 14, 2025.

Round-trip from

$716
(CheapOair)

One-way from

$449
(Turkish Airlines)

Popular in

July

Cheapest in

March

Average price

$864

Good round-trip deal

$824 or less

Good one-way deal

$624 or less
From Panama to Madrid Barajas
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One-way flight from Panama to Madrid Barajas
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Highest demand for flights based on searches. 8% potential increase in price ($69 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a round-trip flight from Panama to Madrid Barajas.
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Price to beat on a one-way flight from Panama to Madrid Barajas.
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Find flight deals from Panama to Madrid

Cheapest flights from Panama to Madrid
Explore the most affordable flight options available from Panama to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This CheapOair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Sun 11/233:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/13$716
This KLM deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/146:50 pmPTY - MAD
1 stop17h 40mKLM
Sun 9/76:00 amMAD - PTY
1 stop17h 50mKLM
Deal found 8/14$717
This KLM deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/136:50 pmPTY - MAD
1 stop34h 15mKLM
Tue 9/25:10 pmMAD - PTY
1 stop30h 40mKLM
Deal found 8/13$718
This CheapOair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/219:55 pmPTY - MAD
1 stop32h 40mTurkish Airlines
Sat 10/46:20 pmMAD - PTY
1 stop32h 40mTurkish Airlines
Deal found 8/13$719
This Avianca deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:55 amPTY - MAD
1 stop14h 25mAvianca
Wed 11/51:20 amMAD - PTY
1 stop13h 30mAvianca
Deal found 8/14$720
This Air Europa deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/288:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Tue 10/73:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/14$721
This Air Europa deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/308:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Tue 10/143:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/13$722
This Avianca deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/263:25 amPTY - MAD
1 stop13h 05mAvianca
Sun 10/59:40 amMAD - PTY
1 stop18h 30mAvianca
Deal found 8/14$729
This Air Europa deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/58:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Fri 10/243:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/13$735
This CheapOair deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/128:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Tue 10/283:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/14$736
This Air Europa deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/148:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Fri 10/313:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/13$737

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Panama to Madrid that are best for you.

Fly from

Panama

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 9/25

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Mon 10/6

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 9/28

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Mon 10/6

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 9/30

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Mon 10/6

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 9/28

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Tue 10/7

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 9/30

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Tue 10/7

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 9/29

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Wed 10/8

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 9/28

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Wed 10/8

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 9/29

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Tue 10/7

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 9/27

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Mon 10/6

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 9/30

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Wed 10/8

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 17 results
1
2

Best time to book a flight from Panama to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Madrid

What is the cheapest month to book a flight from Panama to Madrid?

Currently, November is the cheapest month in which you can book a flight from Panama to Madrid (average of $543). Flying from Panama to Madrid in June is currently the most expensive (average of $1,053). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MAD?

Find hourly flight availability from Panama to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama to Madrid at noon. If you’re flexible enough to do this you can expect to save up to 3% on your trip compared to booking a flight in the morning.

Weekly flight availability from Panama to Madrid

Explore weekly flight availability from Panama to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 14, 2025.

The most flights from PA0 to MAD are scheduled on a Thursday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated August 14, 2025.
Get a feel of what it's like to fly with KLM, Air France, and Air Europa from Panama to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,381 reviews

Crew

8.4

Entertainment

7.1

Food

7.3

Boarding

7.8

Comfort

7.7

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
KLM
7.8
Good
1,381 reviews
KLM
7.8
Good
1,381 reviews

Crew

8.4

Entertainment

7.1

Food

7.3

Boarding

7.8

Comfort

7.7

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Air France
7.4
Good
1,467 reviews
KLM
7.8
Good
1,381 reviews

Crew

8.4

Entertainment

7.1

Food

7.3

Boarding

7.8

Comfort

7.7

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Air Europa
7.0
Good
545 reviews
KLM
7.8
Good
1,381 reviews

Crew

8.4

Entertainment

7.1

Food

7.3

Boarding

7.8

Comfort

7.7

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Iberia
7.0
Good
2,878 reviews
KLM
7.8
Good
1,381 reviews

Crew

8.4

Entertainment

7.1

Food

7.3

Boarding

7.8

Comfort

7.7

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Avianca
6.7
Okay
2,401 reviews
KLM
7.8
Good
1,381 reviews

Crew

8.4

Entertainment

7.1

Food

7.3

Boarding

7.8

Comfort

7.7

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Related info for your journey

Find useful and relevant information for your journey from Panama to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Panama?

    Madrid Barajas (MAD), located 8.5 mi from the city center, is the airport you fly into when you book flights from Panama to Madrid.

  • How popular is this Panama to Madrid flight route?

    This flight path from Panama to Madrid Barajas was viewed by 16 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the most reliable airlines from Panama to Madrid?

    Consider Qatar Airways (100%), Hainan Airlines (100%) or EL AL (97%) when booking your flight. These represent the most reliable airlines when flying from Panama to Madrid.

  • What are the cheapest flights from Panama to Madrid?

    On average you can expect to pay $1,507 for a flight from Panama to Madrid. The cheapest flight overall is $508 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $684.

  • Can I find deals for flights from Panama to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Madrid.

  • Can I find deals for business class flights from Panama to Madrid?

    Yes. Cheapflights offers flight deals from Panama to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Madrid?

    Currently, November is the cheapest month in which you can book a flight from Panama to Madrid (average of $543). Flying from Panama to Madrid in June is currently the most expensive (average of $1,053). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Segovia
Fuenlabrada

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Top 8 airlines flying from Panama to Madrid

Discover the top 8 airlines that operate flights from Panama to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$543Average$715FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$665Average$792FlexibilityNo cancel feeOn-time83%
IberiaCheapest$678Average$825FlexibilityNo cancel feeOn-time77%
KLMCheapest$681Average$792FlexibilityNo cancel feeOn-time75%
Air FranceCheapest$695Average$772FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$787FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$822FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$826Average$1,190FlexibilityNo cancel feeOn-time70%

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