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$449+ Cheap flights from Panama to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/20. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Panama to Madrid

Keep the following information in mind while searching for Panama to Madrid flight deals. Data was last updated May 1, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$698
(KLM)

One-way from

$449
(Kiwi.com)

Popular in

December

Cheapest in

March

Average price

$703

Good round-trip deal

$802 or less

Good one-way deal

$596 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Madrid Barajas flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Madrid Barajas flights.
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From Panama to Madrid Barajas
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One-way flight from Panama to Madrid Barajas
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Highest demand for flights based on searches. 4% potential increase in price ($33 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Price to beat on a round-trip flight from Panama to Madrid Barajas.
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Price to beat on a one-way flight from Panama to Madrid Barajas.
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Find flight deals from Panama to Madrid

Cheapest flights from Panama to Madrid
Explore the most affordable flight options available from Panama to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This KLM deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/106:50 pmPTY - MAD
1 stop21h 35mKLM
Sat 8/231:05 pmMAD - PTY
1 stop34h 45mKLM
Deal found 4/30$698
This KLM deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/156:50 pmPTY - MAD
1 stop34h 15mMultiple Airlines
Sun 9/2110:05 amMAD - PTY
1 stop14h 40mMultiple Airlines
Deal found 4/30$706
This Air France deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/147:55 pmPTY - MAD
1 stop30h 15mAir France
Tue 10/146:00 amMAD - PTY
1 stop18h 45mAir France
Deal found 4/30$710
This Air Europa deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/138:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Sun 9/213:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 4/30$724
This Avianca deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2010:05 pmPTY - MAD
1 stop18h 25mAvianca
Mon 11/38:30 amMAD - PTY
1 stop14h 00mAvianca
Deal found 5/1$725
This Turkish Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/219:55 pmPTY - MAD
1 stop29h 30mTurkish Airlines
Thu 5/2912:00 pmMAD - PTY
1 stop39h 00mTurkish Airlines
Deal found 4/29$740
This Iberia deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/155:20 pmPTY - MAD
Nonstop10h 05mIberia
Fri 9/1912:00 pmMAD - PTY
Nonstop10h 40mIberia
Deal found 5/1$768
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/19:45 amPTY - MAD
2 stops37h 55mUnited Airlines
Wed 10/1511:15 amMAD - PTY
2 stops38h 22mUnited Airlines
Deal found 4/29$845

Cheapflights Fare Finder

Customize your flight search to find flights from Panama to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Panama to Madrid that are best for you.

Fly from

Panama

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 7/23

6:50 pm-12:05 pm

1 stop34h 15m

Madrid Barajas

Wed 8/20

1:05 pm-4:50 pm

1 stop34h 45m

$698

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 9/14

7:55 pm-9:10 am

1 stop30h 15m

Madrid Barajas

Tue 10/14

6:00 am-5:45 pm

1 stop18h 45m

$710

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 8/2

8:05 am-9:35 am

1 stop18h 30m

Madrid Barajas

Wed 8/20

8:25 pm-4:50 pm

1 stop27h 25m

$713

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/16

9:55 pm-10:25 am

1 stop29h 30m

Madrid Barajas

Thu 6/12

6:20 pm-8:00 pm

1 stop32h 40m

$718

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 10/22

3:20 am-11:30 pm

1 stop13h 10m

Madrid Barajas

Mon 11/10

8:30 am-4:30 pm

1 stop14h 00m

$724

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 10/4

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Sat 10/11

3:05 pm-6:40 pm

Nonstop10h 35m

$744

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 5/24

5:35 pm-10:25 am

Nonstop9h 50m

Madrid Barajas

Sat 5/31

12:00 pm-4:05 pm

Nonstop11h 05m

$756

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 10/1

3:30 pm-6:40 am

2 stops32h 10m

Madrid Barajas

Thu 10/16

11:15 am-1:50 pm

2 stops33h 35m

$845

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 7/20

9:55 pm-10:25 am

1 stop29h 30m

$449

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 7/21

11:20 am-3:30 pm

1 stop21h 10m

$514

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 15 results
1
2

Best time to book a flight from Panama to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Madrid

What is the cheapest month to book a flight from Panama to Madrid?

Currently, November is the cheapest month in which you can book a flight from Panama to Madrid (average of $543). Flying from Panama to Madrid in June is currently the most expensive (average of $1,086). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MAD?

Find hourly flight availability from Panama to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama to Madrid at noon. If you’re flexible enough to do this you can expect to save up to 4% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Panama to Madrid?

Use this chart to determine the cheapest time to fly round-trip from Panama to Madrid. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Panama to Madrid flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Wednesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Madrid by month

Plan your trip to Madrid by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Madrid ranges from 0.4 - 2.4 inches per month. November is typically the wettest month, when rainfall can reach 2.4 in. July is typically the driest time to visit Madrid when rainfall is around 0.4 in.

Temperature in Madrid by month

Plan your trip to Madrid by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Madrid, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated May 1, 2025.
To help decide which airline to fly from Panama to Madrid, see what other customers have to say about KLM, Air France and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,334 reviews

Boarding

7.8

Food

7.2

Overall

7.8

Comfort

7.7

Entertainment

7.1

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
KLM
7.8
Good
1,334 reviews
KLM
7.8
Good
1,334 reviews

Boarding

7.8

Food

7.2

Overall

7.8

Comfort

7.7

Entertainment

7.1

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
Air France
7.4
Good
1,446 reviews
KLM
7.8
Good
1,334 reviews

Boarding

7.8

Food

7.2

Overall

7.8

Comfort

7.7

Entertainment

7.1

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
United Airlines
7.4
Good
8,696 reviews
KLM
7.8
Good
1,334 reviews

Boarding

7.8

Food

7.2

Overall

7.8

Comfort

7.7

Entertainment

7.1

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
Turkish Airlines
7.3
Good
3,790 reviews
KLM
7.8
Good
1,334 reviews

Boarding

7.8

Food

7.2

Overall

7.8

Comfort

7.7

Entertainment

7.1

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
Iberia
7.0
Good
2,700 reviews
KLM
7.8
Good
1,334 reviews

Boarding

7.8

Food

7.2

Overall

7.8

Comfort

7.7

Entertainment

7.1

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.

Related info for your journey

Find useful and relevant information for your journey from Panama to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Panama?

    Madrid Barajas (MAD), located 8.5 mi from the city center, is the airport you fly into when you book flights from Panama to Madrid.

  • How popular is this Panama to Madrid flight route?

    This flight path from Panama to Madrid Barajas was viewed by 17 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Panama to Madrid one-way?

    $449 is the cheapest one-way deal found within the past few days, from Turkish Airlines. You may also be able to find cheap deals on Avianca and Air Europa, with prices starting from $514 and $515, respectively.

  • What are the most reliable airlines from Panama to Madrid?

    Consider Air Europa (81%), Etihad Airways (81%) or China Eastern (81%) when booking your flight. These represent the most reliable airlines when flying from Panama to Madrid.

  • What are the cheapest flights from Panama to Madrid?

    On average you can expect to pay $1,712 for a flight from Panama to Madrid. The cheapest flight overall is $466 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $698.

  • Can I find deals for flights from Panama to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Madrid.

  • Can I find deals for business class flights from Panama to Madrid?

    Yes. Cheapflights offers flight deals from Panama to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Madrid?

    Currently, November is the cheapest month in which you can book a flight from Panama to Madrid (average of $543). Flying from Panama to Madrid in June is currently the most expensive (average of $1,086). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama?

Book flights to Panama if you plan to visit one of these locations
Segovia
Fuenlabrada

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Top 7 airlines flying from Panama to Madrid

Discover the top 7 airlines that operate flights from Panama to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$543Average$683FlexibilityNo cancel feeOn-time71%
IberiaCheapest$641Average$818FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$643Average$777FlexibilityNo cancel feeOn-time83%
KLMCheapest$670Average$800FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$678Average$813FlexibilityNo cancel feeOn-time69%
Air FranceCheapest$681Average$772FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$787Average$849FlexibilityNo cancel feeOn-time77%

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