What’s the top layover airport for flights from Knoxville to Madrid?

Philadelphia (PHL) – chosen by Cheapflights users on 83% of 1-stop itineraries from Knoxville to Madrid on Cheapflights.

Which airport typically offers the quickest layover for flights from Knoxville to Madrid?

Flights via Philadelphia (PHL) offer the fastest connection on this route, with an average layover time of 1h 55m.

What’s the cheapest layover airport for flights from Knoxville to Madrid?

Philadelphia (PHL) is the most affordable 1-stop option, with an average round-trip price of $640.

What’s the fastest layover option from Knoxville to Madrid?

Flights via Philadelphia (PHL) have the shortest average one-way travel time for 1-stop routes: 9h 40m.

How long is the flight from Knoxville to Madrid?

Departing from Knoxville to Madrid will take you 17h 21m. There are 4222 mi between Knoxville and Madrid. This flight may include one or multiple stops.

What are the cheapest airlines flying from Knoxville to Madrid round-trip?

According to our current data, United Airlines ($562), British Airways ($594), and American Airlines ($594) offers the cheapest pricing from Knoxville to Madrid. United Airlines is currently priced 42% below the average price you’ll pay for this route.

What is the cheapest day to fly from Knoxville to Madrid?

Travelers seeking maximum savings on their Knoxville to Madrid flight should consider departing on Thursday afternoons when fares are most often at their lowest. Tuesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Madrid ranges from 0.4 - 2.4 inches per month. November is typically the wettest month, when rainfall can reach 2.4 in. July is typically the driest time to visit Madrid when rainfall is around 0.4 in.

If weather is an important factor for your trip to Madrid, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What are the most popular airlines that fly from Knoxville to Madrid?

The most popular airlines flying from Knoxville to Madrid are American Airlines, British Airways and United Airlines. Something to consider prior to booking your flight.

Can I find deals for flights from Knoxville to Madrid that include hotel bookings?

Yes. In addition to deals on Knoxville to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Madrid?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Madrid.

Can I find deals for business class flights from Knoxville to Madrid?

Yes. Cheapflights offers flight deals from Knoxville to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$250+ Flights from Knoxville to Madrid, Spain

Q: How much does it cost to fly round-trip from Knoxville to Madrid?

Airfare is below average for this route at the moment. Knoxville to Madrid flights typically cost between $639 and $1,140 in October. The cheapest round-trip price found within the last 3 days was $530 on American Airlines (Oct 6-Oct 22).

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Cheap flight deals from Knoxville to Madrid

Round-trip from	$530 (American Airlines)
One-way from	$250 (Kiwi.com)
Popular in	June
Cheapest in	January
Average price	$790

From Knoxville McGhee Tyson to Madrid Barajas

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One-way flight from Knoxville McGhee Tyson to Madrid Barajas

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Highest demand for flights based on searches. 25% potential increase in price ($339 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($47 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Cheapest flights from Knoxville to Madrid
Explore the most affordable flight options available from Knoxville to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Mon 10/61:01 pmTYS - MAD

1 stop12h 54mAmerican Airlines

Wed 10/2211:50 amMAD - TYS

1 stop16h 19mAmerican Airlines

Deal found 9/13

$530

Tue 11/251:25 pmTYS - MAD

1 stop10h 20mMultiple Airlines

Fri 12/511:35 amMAD - TYS

1 stop16h 03mMultiple Airlines

Deal found 9/16

$537

Tue 11/258:59 amTYS - MAD

1 stop14h 46mAmerican Airlines

Fri 12/512:30 pmMAD - TYS

2 stops15h 06mAmerican Airlines

Deal found 9/16

$542

Tue 11/115:45 amTYS - MAD

2 stops20h 15mUnited Airlines

Wed 11/195:55 amMAD - TYS

2 stops24h 04mUnited Airlines

Deal found 9/13

$543

Tue 11/255:45 amTYS - MAD

2 stops28h 25mUnited Airlines

Fri 12/51:35 pmMAD - TYS

2 stops31h 08mUnited Airlines

Deal found 9/16

$546

Wed 11/53:59 pmTYS - MAD

2 stops17h 21mDelta

Thu 11/1311:15 amMAD - TYS

1 stop14h 51mDelta

Deal found 9/13

$556

Thu 11/65:45 amTYS - MAD

2 stops20h 15mUnited Airlines

Fri 11/141:35 pmMAD - TYS

2 stops39h 20mUnited Airlines

Deal found 9/15

$564

Wed 11/51:52 pmTYS - MAD

2 stops20h 48mUnited Airlines

Fri 11/141:35 pmMAD - TYS

2 stops26h 30mUnited Airlines

Deal found 9/15

$565

Wed 11/51:52 pmTYS - MAD

2 stops20h 48mUnited Airlines

Wed 11/195:55 amMAD - TYS

2 stops23h 00mUnited Airlines

Deal found 9/15

$571

Sun 11/93:51 pmTYS - MAD

1 stop11h 24mDelta

Wed 11/196:00 amMAD - TYS

2 stops19h 00mDelta

Deal found 9/15

$576

Best flights from Knoxville to Madrid
Discover carefully curated flight deals from Knoxville to Madrid that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2025.

Tue 11/251:25 pmTYS - MAD

1 stop10h 20mMultiple Airlines

Fri 12/511:35 amMAD - TYS

1 stop16h 03mMultiple Airlines

Deal found 9/16

$537

Wed 11/53:59 pmTYS - MAD

2 stops17h 21mDelta

Thu 11/1310:00 amMAD - TYS

2 stops16h 06mDelta

Deal found 9/15

$561

Thu 11/65:45 amTYS - MAD

2 stops20h 15mAir Canada

Fri 11/141:35 pmMAD - TYS

2 stops31h 08mAir Canada

Deal found 9/15

$564

Thu 11/65:45 amTYS - MAD

2 stops20h 15mUnited Airlines

Fri 11/141:35 pmMAD - TYS

2 stops39h 20mUnited Airlines

Deal found 9/15

$564

Mon 2/162:45 pmTYS - MAD

2 stops12h 30mUnited Airlines

Mon 2/231:35 pmMAD - TYS

2 stops37h 32mUnited Airlines

Deal found 9/14

$569

Thu 10/212:51 pmTYS - MAD

1 stop13h 04mMultiple Airlines

Fri 10/1011:35 amMAD - TYS

1 stop15h 28mMultiple Airlines

Deal found 9/16

$587

Mon 2/168:47 amTYS - MAD

1 stop18h 13mDelta

Mon 2/2311:00 amMAD - TYS

1 stop18h 44mDelta

Deal found 9/15

$587

Mon 11/101:52 pmTYS - MAD

2 stops19h 58mUnited Airlines

Wed 11/195:55 amMAD - TYS

2 stops24h 04mUnited Airlines

Deal found 9/13

$570

Sun 2/1511:10 amTYS - MAD

1 stop12h 25mMultiple Airlines

Sun 2/2210:00 amMAD - TYS

1 stop13h 35mMultiple Airlines

Deal found 9/14

$587

Thu 11/610:50 amTYS - MAD

1 stop12h 55mMultiple Airlines

Fri 11/141:00 pmMAD - TYS

1 stop15h 51mMultiple Airlines

Deal found 9/15

$587

Last-minute flights from Knoxville to Madrid
Discover last-minute flight deals from Knoxville to Madrid. Data last updated September 16, 2025 and is based on user searches.

Sun 9/218:36 pmTYS - MAD

1 stop26h 54mBritish Airways

Tue 9/301:00 pmMAD - TYS

1 stop11h 50mBritish Airways

Deal found 9/14

$805

Sun 9/217:20 amTYS - MAD

2 stops18h 45mUnited Airlines

Tue 9/3012:45 pmMAD - TYS

2 stops38h 26mUnited Airlines

Deal found 9/14

$977

Thu 10/212:51 pmTYS - MAD

1 stop13h 04mMultiple Airlines

Fri 10/1011:35 amMAD - TYS

1 stop15h 28mMultiple Airlines

Deal found 9/16

$587

Thu 10/212:51 pmTYS - MAD

1 stop13h 04mMultiple Airlines

Sat 10/114:00 pmMAD - TYS

1 stop25h 44mMultiple Airlines

Deal found 9/15

$823

Thu 10/27:00 amTYS - MAD

2 stops17h 40mUnited Airlines

Fri 10/1012:45 pmMAD - TYS

2 stops27h 25mUnited Airlines

Deal found 9/15

$877

Thu 10/28:31 pmTYS - MAD

2 stops37h 44mBritish Airways

Sat 10/115:25 pmMAD - TYS

2 stops28h 28mBritish Airways

Deal found 9/16

$959

Fri 10/36:24 pmTYS - MAD

1 stop14h 01mMultiple Airlines

Tue 10/1411:30 amMAD - TYS

1 stop18h 09mMultiple Airlines

Deal found 9/15

$956

Mon 10/61:01 pmTYS - MAD

1 stop12h 54mAmerican Airlines

Wed 10/2211:50 amMAD - TYS

1 stop16h 19mAmerican Airlines

Deal found 9/13

$530

Mon 10/611:35 amTYS - MAD

1 stop16h 00mDelta

Wed 10/2212:40 pmMAD - TYS

2 stops26h 40mDelta

Deal found 9/13

$592

One-way flights from Knoxville to Madrid
Search for one-way flight options from Knoxville to Madrid. Find affordable one-way fares based on user searches. Data last updated September 16, 2025.

Mon 2/27:15 amTYS - MAD

2 stops33h 25mMultiple Airlines

Deal found 9/15

$250

Fri 1/307:15 amTYS - MAD

2 stops30h 35mMultiple Airlines

Deal found 9/15

$252

Sat 1/315:59 pmTYS - MAD

3 stops44h 16mMultiple Airlines

Deal found 9/15

$337

Tue 2/31:00 pmTYS - MAD

3 stops47h 05mMultiple Airlines

Deal found 9/15

$351

Thu 2/59:29 amTYS - MAD

3 stops48h 41mMultiple Airlines

Deal found 9/15

$379

Sun 2/11:39 pmTYS - MAD

2 stops24h 41mMultiple Airlines

Deal found 9/15

$400

Tue 2/311:55 amTYS - MAD

1 stop14h 05mDelta

Deal found 9/15

$443

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Tue 11/25

1:25 pm-5:45 am

1 stop10h 20m

Madrid Barajas

Fri 12/5

11:35 am-9:38 pm

1 stop16h 03m

$537

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 11/5

3:59 pm-3:20 pm

2 stops17h 21m

Madrid Barajas

Thu 11/13

10:00 am-8:06 pm

2 stops16h 06m

$561

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Thu 11/6

5:45 am-8:00 am

2 stops20h 15m

Madrid Barajas

Fri 11/14

1:35 pm-2:43 pm

2 stops31h 08m

$564

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Thu 11/6

5:45 am-8:00 am

2 stops20h 15m

Madrid Barajas

Fri 11/14

1:35 pm-10:55 pm

2 stops39h 20m

$564

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 2/16

2:45 pm-9:15 am

2 stops12h 30m

Madrid Barajas

Mon 2/23

1:35 pm-9:07 pm

2 stops37h 32m

$569

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 11/10

1:52 pm-3:50 pm

2 stops19h 58m

Madrid Barajas

Wed 11/19

5:55 am-11:59 pm

2 stops24h 04m

$570

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Thu 10/2

12:51 pm-7:55 am

1 stop13h 04m

Madrid Barajas

Fri 10/10

11:35 am-9:03 pm

1 stop15h 28m

$587

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 2/16

8:47 am-9:00 am

1 stop18h 13m

Madrid Barajas

Mon 2/23

11:00 am-11:44 pm

1 stop18h 44m

$587

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sun 2/15

11:10 am-5:35 am

1 stop12h 25m

Madrid Barajas

Sun 2/22

10:00 am-5:35 pm

1 stop13h 35m

$587

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Thu 11/6

10:50 am-5:45 am

1 stop12h 55m

Madrid Barajas

Fri 11/14

1:00 pm-10:51 pm

1 stop15h 51m

$587

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 20 results

Best time to book a flight from Knoxville to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Madrid

Prices

What is the cheapest month to book a flight from Knoxville to Madrid?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Madrid (average of $543). Flying from Knoxville to Madrid in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MAD?

Unlike in the evening, when flights are generally more expensive, you can save up to 25% on flights from Knoxville to Madrid by exploring options for tickets in the afternoon.

How much does it cost to fly round-trip from Knoxville to Madrid?

Reviews of airlines servicing Madrid

See what other customers who have flown with United Airlines, American Airlines, and British Airways from Knoxville to Madrid have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

United Airlines

7.4

Good

8,924 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

United Airlines

7.4

Good

8,924 reviews

United Airlines

7.4

Good

8,924 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

American Airlines

7.2

Good

10,000 reviews

United Airlines

7.4

Good

8,924 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

British Airways

6.7

Okay

7,363 reviews

United Airlines

7.4

Good

8,924 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

How long is the flight from Knoxville to Madrid?
Departing from Knoxville to Madrid will take you 17h 21m. There are 4222 mi between Knoxville and Madrid. This flight may include one or multiple stops.
What are the cheapest airlines flying from Knoxville to Madrid round-trip?
According to our current data, United Airlines ($562), British Airways ($594), and American Airlines ($594) offers the cheapest pricing from Knoxville to Madrid. United Airlines is currently priced 42% below the average price you’ll pay for this route.
Can I find deals for flights from Knoxville to Madrid that include hotel bookings?
Yes. In addition to deals on Knoxville to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Madrid?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Madrid.
Can I find deals for business class flights from Knoxville to Madrid?
Yes. Cheapflights offers flight deals from Knoxville to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Madrid?
Currently, November is the cheapest month in which you can book a flight from Knoxville to Madrid (average of $543). Flying from Knoxville to Madrid in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Fuenlabrada

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Alternative routes for Knoxville to Madrid

Nashville to Madrid flights

Memphis to Madrid flights

Other flights to Madrid

Top 3 airlines flying from Knoxville to Madrid

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$562	Average$875	FlexibilityNo cancel fee	On-time69%
British Airways	Cheapest$594	Average$800	FlexibilityNo cancel fee	On-time70%
American Airlines	Cheapest$594	Average$1,106	FlexibilityNo cancel fee	On-time71%

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$250+ Cheap flights from Knoxville (TYS) to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.

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Find flight deals from Knoxville to Madrid

Cheapest flights from Knoxville to MadridExplore the most affordable flight options available from Knoxville to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Explore the most affordable flight options available from Knoxville to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Madrid that are best for you.

Best time to book a flight from Knoxville to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Madrid

What is the cheapest month to book a flight from Knoxville to Madrid?

What is the cheapest time of day to fly from TYS to MAD?

How much does it cost to fly round-trip from Knoxville to Madrid?

What’s the top layover airport for flights from Knoxville to Madrid?

What’s the fastest layover option from Knoxville to Madrid?

What’s the fastest layover option from Knoxville to Madrid?

Which airport typically offers the quickest layover for flights from Knoxville to Madrid?

Reviews of airlines servicing Madrid

See what other customers who have flown with United Airlines, American Airlines, and British Airways from Knoxville to Madrid have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Knoxville to Madrid?

What are the cheapest airlines flying from Knoxville to Madrid round-trip?

Can I find deals for flights from Knoxville to Madrid that include hotel bookings?

How can I find direct flights from Knoxville to Madrid?

Can I find deals for business class flights from Knoxville to Madrid?

What is the cheapest month to book a flight from Knoxville to Madrid?

Traveling to a place near Madrid?

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Alternative routes for Knoxville to Madrid

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Knoxville to Madrid

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Cheapest flights from Knoxville to Madrid
Explore the most affordable flight options available from Knoxville to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.