How long is the flight from Missouri to Lyon?

There are many flights that can get you from Missouri to Lyon in 15h 25m. Fly via United Airlines or Lufthansa to get the fastest option. There are 4602 mi between Missouri and Lyon.

In terms of precipitation, rainfall in Lyon ranges from 1.6 - 3.1 inches per month. October is typically the wettest month, when rainfall can reach 3.1 in. January is typically the driest time to visit Lyon when rainfall is around 1.6 in.

If weather is an important factor for your trip to Lyon, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 37.4 F).

What airport do you fly into for flights to Lyon from Missouri?

Most people fly into Lyon-Saint Exupéry (LYS) if they book a flight to Lyon from Missouri. Lyon-Saint Exupéry is conveniently located just 12.5 mi from Lyon’s city center.

Can I find deals for flights from Missouri to Lyon that include hotel bookings?

Yes. In addition to deals on Missouri to Lyon flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Lyon?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Lyon.

Can I find deals for business class flights from Missouri to Lyon?

Yes. Cheapflights offers flight deals from Missouri to Lyon by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$421+ Flights from Missouri to Lyon

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Missouri to Lyon with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Lyon

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$676 (United Airlines)
One-way from	$421 (Orbitz)

Provider with most accurate pricing for Lambert-St Louis-Lyon-Saint Exupéry flight deals.

Search Deals

Provider most trusted by Cheapflights users for Lambert-St Louis-Lyon-Saint Exupéry flights.

Search Deals

From Missouri to Lyon-Saint Exupéry

Search Deals

One-way flight from Missouri to Lyon-Saint Exupéry

Search Deals

Find flight deals from Missouri to Lyon

Cheapest flights from Missouri to Lyon
Explore the most affordable flight options available from Missouri to Lyon. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

Wed 12/317:40 amMCI - LYS

2 stops27h 20mUnited Airlines

Thu 1/810:40 amLYS - MCI

2 stops30h 52mUnited Airlines

Deal found 11/1

$699

Wed 12/316:00 amMCI - LYS

2 stops29h 00mUnited Airlines

Wed 1/71:05 pmLYS - MCI

2 stops57h 05mUnited Airlines

Deal found 11/2

$711

Tue 12/303:29 pmMCI - LYS

2 stops14h 56mDelta

Thu 1/812:25 pmLYS - MCI

2 stops35h 44mDelta

Deal found 11/1

$738

Sat 12/138:00 amMCI - LYS

2 stops20h 05mUnited Airlines

Sun 1/111:05 pmLYS - MCI

2 stops39h 54mUnited Airlines

Deal found 10/31

$742

Tue 12/307:40 amMCI - LYS

2 stops23h 30mUnited Airlines

Wed 1/71:05 pmLYS - MCI

2 stops57h 05mUnited Airlines

Deal found 11/2

$797

Sat 12/136:00 amMCI - LYS

2 stops22h 05mUnited Airlines

Sat 12/271:55 pmLYS - MCI

2 stops37h 36mUnited Airlines

Deal found 10/31

$807

Wed 12/317:40 amMCI - LYS

2 stops27h 20mUnited Airlines

Mon 1/510:40 amLYS - MCI

2 stops42h 19mUnited Airlines

Deal found 11/1

$812

Wed 12/317:40 amMCI - LYS

2 stops27h 20mUnited Airlines

Tue 1/610:45 amLYS - MCI

2 stops59h 25mUnited Airlines

Deal found 11/2

$820

Sat 12/138:00 amMCI - LYS

2 stops20h 05mUnited Airlines

Sun 12/286:10 amLYS - MCI

2 stops21h 21mUnited Airlines

Deal found 10/31

$832

Fri 11/76:06 amMCI - LYS

2 stops21h 59mUnited Airlines

Fri 11/216:25 amLYS - MCI

2 stops23h 03mUnited Airlines

Deal found 11/1

$866

Sat 12/276:00 amMCI - LYS

2 stops20h 55mUnited Airlines

Thu 1/810:40 amLYS - MCI

2 stops30h 52mUnited Airlines

Deal found 11/1

$877

Sun 12/287:40 amMCI - LYS

2 stops27h 00mUnited Airlines

Thu 1/810:40 amLYS - MCI

2 stops30h 52mUnited Airlines

Deal found 11/1

$879

Best flights from Missouri to Lyon
Discover carefully curated flight deals from Missouri to Lyon that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2025.

Fri 3/274:50 pmSTL - LYS

1 stop15h 25mUnited Airlines

Tue 3/311:45 pmLYS - STL

2 stops28h 24mUnited Airlines

Deal found 11/1

$682

Fri 3/274:50 pmSTL - LYS

1 stop15h 25mLufthansa

Tue 3/3110:25 amLYS - STL

1 stop34h 05mLufthansa

Deal found 11/1

$718

Fri 3/2710:00 amSTL - LYS

2 stops18h 05mAir Canada

Tue 3/311:45 pmLYS - STL

2 stops29h 35mAir Canada

Deal found 10/30

$855

Fri 3/275:59 pmSTL - LYS

2 stops17h 31mBritish Airways

Tue 3/3111:20 amLYS - STL

2 stops17h 28mBritish Airways

Deal found 11/1

$943

Wed 12/317:40 amMCI - LYS

2 stops27h 20mUnited Airlines

Thu 1/810:40 amLYS - MCI

2 stops30h 52mUnited Airlines

Deal found 11/1

$699

Wed 12/316:00 amMCI - LYS

2 stops29h 00mUnited Airlines

Wed 1/71:05 pmLYS - MCI

2 stops57h 05mUnited Airlines

Deal found 11/2

$711

Sat 12/138:00 amMCI - LYS

2 stops20h 05mUnited Airlines

Sun 1/111:05 pmLYS - MCI

2 stops39h 54mUnited Airlines

Deal found 10/31

$742

Tue 12/307:40 amMCI - LYS

2 stops23h 30mUnited Airlines

Wed 1/71:05 pmLYS - MCI

2 stops57h 05mUnited Airlines

Deal found 11/2

$797

Sat 12/136:00 amMCI - LYS

2 stops22h 05mUnited Airlines

Sat 12/271:55 pmLYS - MCI

2 stops37h 36mUnited Airlines

Deal found 10/31

$807

Thu 1/17:40 amMCI - LYS

2 stops27h 40mUnited Airlines

Mon 1/510:40 amLYS - MCI

2 stops42h 19mUnited Airlines

Deal found 11/1

$812

Wed 12/317:40 amMCI - LYS

2 stops27h 20mUnited Airlines

Mon 1/510:40 amLYS - MCI

2 stops42h 19mUnited Airlines

Deal found 11/1

$812

Wed 12/317:40 amMCI - LYS

2 stops27h 20mUnited Airlines

Tue 1/610:45 amLYS - MCI

2 stops59h 25mUnited Airlines

Deal found 11/2

$820

Sat 12/138:00 amMCI - LYS

2 stops20h 05mUnited Airlines

Sun 12/286:10 amLYS - MCI

2 stops21h 21mUnited Airlines

Deal found 10/31

$832

Fri 11/76:06 amMCI - LYS

2 stops21h 59mUnited Airlines

Fri 11/216:25 amLYS - MCI

2 stops23h 03mUnited Airlines

Deal found 11/1

$866

Sat 12/276:00 amMCI - LYS

2 stops20h 55mUnited Airlines

Thu 1/810:40 amLYS - MCI

2 stops30h 52mUnited Airlines

Deal found 11/1

$877

Sat 12/276:00 amMCI - LYS

2 stops20h 55mUnited Airlines

Wed 1/71:05 pmLYS - MCI

2 stops57h 05mUnited Airlines

Deal found 11/2

$889

Last-minute flights from Missouri to Lyon
Discover last-minute flight deals from Missouri to Lyon. Data last updated November 3, 2025 and is based on user searches.

Fri 11/76:06 amMCI - LYS

2 stops21h 59mUnited Airlines

Fri 11/216:25 amLYS - MCI

2 stops23h 03mUnited Airlines

Deal found 11/1

$866

Fri 11/76:00 amMCI - LYS

2 stops26h 30mMultiple Airlines

Fri 11/217:05 amLYS - MCI

3 stops39h 14mMultiple Airlines

Deal found 11/1

$1,084

One-way flights from Missouri to Lyon
Search for one-way flight options from Missouri to Lyon. Find affordable one-way fares based on user searches. Data last updated November 3, 2025.

Fri 12/264:05 pmSTL - LYS

2 stops36h 00mAir Canada

Deal found 11/2

$421

Fri 12/263:50 pmSTL - LYS

1 stop11h 15mLufthansa

Deal found 11/2

$670

Fri 12/268:42 pmSTL - LYS

3 stops38h 33mMultiple Airlines

Deal found 11/2

$711

Fly from

Fly to

Route

Depart

Return

Price

St. LouisLyon

STL - LYS

STLLYS

Lambert-St Louis

Fri 3/27

4:50 pm-2:15 pm

1 stop15h 25m

Lyon-Saint Exupéry

Tue 3/31

1:45 pm-11:09 am

2 stops28h 24m

$682

Kansas CityLyon

MCI - LYS

MCILYS

Kansas City

Wed 12/31

7:40 am-6:00 pm

2 stops27h 20m

Lyon-Saint Exupéry

Thu 1/8

10:40 am-10:32 am

2 stops30h 52m

$699

Kansas CityLyon

MCI - LYS

MCILYS

Kansas City

Wed 12/31

6:00 am-6:00 pm

2 stops29h 00m

Lyon-Saint Exupéry

Wed 1/7

1:05 pm-3:10 pm

2 stops57h 05m

$711

St. LouisLyon

STL - LYS

STLLYS

Lambert-St Louis

Fri 3/27

4:50 pm-2:15 pm

1 stop15h 25m

Lyon-Saint Exupéry

Tue 3/31

10:25 am-1:30 pm

1 stop34h 05m

$718

Kansas CityLyon

MCI - LYS

MCILYS

Kansas City

Sat 12/13

8:00 am-11:05 am

2 stops20h 05m

Lyon-Saint Exupéry

Sun 1/11

1:05 pm-9:59 pm

2 stops39h 54m

$742

Kansas CityLyon

MCI - LYS

MCILYS

Kansas City

Tue 12/30

7:40 am-2:10 pm

2 stops23h 30m

Lyon-Saint Exupéry

Wed 1/7

1:05 pm-3:10 pm

2 stops57h 05m

$797

Kansas CityLyon

MCI - LYS

MCILYS

Kansas City

Sat 12/13

6:00 am-11:05 am

2 stops22h 05m

Lyon-Saint Exupéry

Sat 12/27

1:55 pm-8:31 pm

2 stops37h 36m

$807

Kansas CityLyon

MCI - LYS

MCILYS

Kansas City

Thu 1/1

7:40 am-6:20 pm

2 stops27h 40m

Lyon-Saint Exupéry

Mon 1/5

10:40 am-9:59 pm

2 stops42h 19m

$812

Kansas CityLyon

MCI - LYS

MCILYS

Kansas City

Wed 12/31

7:40 am-6:00 pm

2 stops27h 20m

Lyon-Saint Exupéry

Mon 1/5

10:40 am-9:59 pm

2 stops42h 19m

$812

Kansas CityLyon

MCI - LYS

MCILYS

Kansas City

Wed 12/31

7:40 am-6:00 pm

2 stops27h 20m

Lyon-Saint Exupéry

Tue 1/6

10:45 am-3:10 pm

2 stops59h 25m

$820

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 19 results

Best time to book a flight from Missouri to Lyon

Have a flexible travel schedule? Discover the best time to fly to Lyon from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Lyon

What is the cheapest time of day to fly from MO to LYS?

Unlike in the evening, when flights are generally more expensive, you can save up to 33% on flights from Missouri to Lyon by exploring options for tickets in the morning.

Related info for your journey

What airport do you fly into for flights to Lyon from Missouri?
Most people fly into Lyon-Saint Exupéry (LYS) if they book a flight to Lyon from Missouri. Lyon-Saint Exupéry is conveniently located just 12.5 mi from Lyon’s city center.
How long is the flight from Missouri to Lyon?
There are many flights that can get you from Missouri to Lyon in 15h 25m. Fly via United Airlines or Lufthansa to get the fastest option. There are 4602 mi between Missouri and Lyon.
Can I find deals for flights from Missouri to Lyon that include hotel bookings?
Yes. In addition to deals on Missouri to Lyon flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Lyon?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Lyon.
Can I find deals for business class flights from Missouri to Lyon?
Yes. Cheapflights offers flight deals from Missouri to Lyon by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Annemasse

Huez

Browse thousands of different options on Cheapflights for your next trip

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$421+ Cheap flights from Missouri to Lyon (LYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/26. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Missouri to Lyon with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Missouri to Lyon

Keep the following information in mind while searching for Missouri to Lyon flight deals. Data was last updated November 3, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Find flight deals from Missouri to Lyon

Cheapest flights from Missouri to LyonExplore the most affordable flight options available from Missouri to Lyon. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

Explore the most affordable flight options available from Missouri to Lyon. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Lyon that are best for you.

Best time to book a flight from Missouri to Lyon

Have a flexible travel schedule? Discover the best time to fly to Lyon from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Lyon

What is the cheapest time of day to fly from MO to LYS?

Find hourly flight availability from Missouri to Lyon. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Lyon. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Lyon from Missouri?

How long is the flight from Missouri to Lyon?

Can I find deals for flights from Missouri to Lyon that include hotel bookings?

How can I find direct flights from Missouri to Lyon?

Can I find deals for business class flights from Missouri to Lyon?

Traveling to a place near Lyon?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Lyon

See prices for flight routes from nearby airports that may be better suited for you.

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Missouri to Lyon
Explore the most affordable flight options available from Missouri to Lyon. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.