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$458+ Cheap flights from Panama City (PTY) to Louisville (SDF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDF
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Find flight deals from Panama City to Louisville

Cheapest flights from Panama City to Louisville
Explore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/53:21 pmPTY - SDF
1 stop7h 13mDelta
Sat 11/298:35 amSDF - PTY
1 stop11h 24mDelta
Deal found 10/28$545
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/58:55 amPTY - SDF
2 stops13h 34mUnited Airlines
Tue 11/257:10 amSDF - PTY
1 stop7h 35mUnited Airlines
Deal found 10/27$592
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/52:49 pmPTY - SDF
2 stops22h 23mAmerican Airlines
Tue 11/257:31 pmSDF - PTY
2 stops18h 12mAmerican Airlines
Deal found 10/27$619
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/172:49 pmPTY - SDF
1 stop8h 52mAmerican Airlines
Sun 11/307:31 pmSDF - PTY
2 stops18h 12mAmerican Airlines
Deal found 10/28$625
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:41 pmPTY - SDF
1 stop20h 44mUnited Airlines
Mon 11/39:00 amSDF - PTY
2 stops10h 38mUnited Airlines
Deal found 10/29$657
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/58:55 amPTY - SDF
2 stops13h 34mUnited Airlines
Sat 11/297:10 amSDF - PTY
1 stop12h 28mUnited Airlines
Deal found 10/28$686
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/52:49 pmPTY - SDF
2 stops25h 40mAmerican Airlines
Sat 11/2912:43 pmSDF - PTY
2 stops25h 00mAmerican Airlines
Deal found 10/28$714
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/55:50 pmPTY - SDF
2 stops24h 26mMultiple Airlines
Tue 11/256:48 pmSDF - PTY
3 stops29h 52mMultiple Airlines
Deal found 10/27$803
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/162:55 amPTY - SDF
2 stops16h 01mMultiple Airlines
Sun 11/308:31 pmSDF - PTY
3 stops28h 09mMultiple Airlines
Deal found 10/28$831

Cheap flight deals from Panama City to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$458
(United Airlines)

Popular in

January

Cheapest in

October

Average price

$468
Provider with most accurate pricing for Panama City Tocumen Intl-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Louisville Intl flights.
Search Deals
From Panama City Tocumen Intl to Louisville Intl
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($104 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($43 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Panama City to Louisville that are best for you.

Fly from

Panama City

Fly to

Louisville

Route

Depart

Return

Price

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Fri 3/6

8:55 am-9:30 pm

1 stop12h 35m

Louisville Intl

Tue 3/10

9:32 am-6:38 pm

1 stop10h 06m

$458

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Mon 11/17

2:49 pm-10:11 am

2 stops19h 22m

Louisville Intl

Sun 11/30

7:31 pm-1:43 pm

2 stops18h 12m

$625

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Sun 11/16

2:55 am-6:56 pm

2 stops16h 01m

Louisville Intl

Sun 11/30

8:31 pm-12:40 am

3 stops28h 09m

$831

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Compare providers for flights from Panama City to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Louisville in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Louisville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Louisville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Louisville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Louisville

What is the cheapest month to book a flight from Panama City to Louisville?

Currently, August is the cheapest month in which you can book a flight from Panama City to Louisville (average of $221). Flying from Panama City to Louisville in January is currently the most expensive (average of $563). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SDF?

Find hourly flight availability from Panama City to Louisville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

One of the essential ways to save on airfare from Panama City to Louisville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 23% on airfare.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated October 29, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Panama City to Louisville to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,992 reviews

Overall

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!
Delta
7.9
Good
7,992 reviews
Delta
7.9
Good
7,992 reviews

Overall

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!
United Airlines
7.4
Good
8,999 reviews
Delta
7.9
Good
7,992 reviews

Overall

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,992 reviews

Overall

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!

Related info for your journey

Find useful and relevant information for your journey from Panama City to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Louisville?

    For as low as $458, United Airlines can have you in Louisville from Panama City in 12h 35m. There are 2048 mi between Panama City and Louisville.

  • What are the cheapest airlines flying from Panama City to Louisville round-trip?

    Flying on Delta is currently your cheapest option to Louisville, with prices starting at $338. Additional round-trip tickets that might be worth considering are offered by United Airlines and American Airlines, with the lowest prices starting at $366 and $370, respectively. You may be able to fly from Panama City to Louisville for 41% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Louisville that include hotel bookings?

    Yes. In addition to deals on Panama City to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Louisville.

  • Can I find deals for business class flights from Panama City to Louisville?

    Yes. Cheapflights offers flight deals from Panama City to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Louisville?

    Currently, August is the cheapest month in which you can book a flight from Panama City to Louisville (average of $221). Flying from Panama City to Louisville in January is currently the most expensive (average of $563). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Alternative routes for Panama City to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Cincinnati flights
Panama City to Nashville flights

Top 3 airlines flying from Panama City to Louisville

Discover the top 3 airlines that operate flights from Panama City to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$338Average$526FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$366Average$557FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$370Average$627FlexibilityNo cancel feeOn-time71%

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