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$377+ Cheap flights from Panama City (PTY) to Louisville (SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDF
Apr 15 — Apr 221
Wed 4/15
Wed 4/22
1 adult, Economy
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Cheap flight deals from Panama City to Louisville

Cheapest flights from Panama City to Louisville
Explore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.

This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:55 pm
PTY
-
SDF
2 stops14h 12m
United Airlines
Mon 5/117:56 pm
SDF
-
PTY
2 stops19h 18m
United Airlines
Deal found 3/12$547
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:55 am
PTY
-
SDF
1 stop13h 20m
United Airlines
Thu 5/289:30 am
SDF
-
PTY
1 stop10h 07m
United Airlines
Deal found 3/12$556
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:55 am
PTY
-
SDF
1 stop11h 05m
United Airlines
Sun 5/247:10 am
SDF
-
PTY
2 stops13h 21m
United Airlines
Deal found 3/13$560
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/271:49 pm
PTY
-
SDF
1 stop9h 10m
American Airlines
Mon 5/47:52 pm
SDF
-
PTY
2 stops17h 54m
American Airlines
Deal found 3/13$562
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:43 pm
PTY
-
SDF
1 stop8h 56m
American Airlines
Mon 12/76:00 am
SDF
-
PTY
1 stop9h 37m
American Airlines
Deal found 3/13$567
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:30 pm
PTY
-
SDF
2 stops16h 55m
United Airlines
Mon 5/117:56 pm
SDF
-
PTY
2 stops19h 18m
United Airlines
Deal found 3/14$568

Find flight deals from Panama City to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$547
(United Airlines)

One-way from

$377
(Kiwi.com)

Popular in

January

Cheapest in

November

Average price

$581
Provider with most accurate pricing for Panama City Tocumen Intl-Louisville Intl flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Louisville Intl flights.
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From Panama City Tocumen Intl to Louisville Intl
Search Deals
One-way flight from Panama City Tocumen Intl to Louisville Intl
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($126 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Panama City to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Fri 5/1

10:55 pm-2:07 pm

2 stops14h 12m

Louisville Intl

Mon 5/11

7:56 pm-2:14 pm

2 stops19h 18m

$547
Quickest round-trip

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Tue 5/26

7:55 am-10:15 pm

1 stop13h 20m

Louisville Intl

Thu 5/28

9:30 am-6:37 pm

1 stop10h 07m

$556

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Sat 5/16

9:45 am-10:22 pm

1 stop11h 37m

Louisville Intl

Sun 5/24

7:10 am-7:31 pm

2 stops13h 21m

$560

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Wed 5/13

7:55 am-9:59 pm

1 stop13h 04m

Louisville Intl

Wed 5/27

9:00 am-6:37 pm

2 stops10h 37m

$568
Cheapest one-way
Quickest one-way

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Wed 4/1

1:40 pm-11:59 pm

1 stop9h 19m

$382

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Tue 3/24

3:41 pm-7:51 pm

1 stop27h 10m

$399

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Tue 3/24

9:45 am-11:14 am

3 stops24h 29m

$551

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/13

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Panama City-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Louisville

What is the cheapest month to book a flight from Panama City to Louisville?

Currently, August is the cheapest month in which you can book a flight from Panama City to Louisville (average of $217). Flying from Panama City to Louisville in January is currently the most expensive (average of $518). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated March 16, 2026.
Peruse reviews from past customers who have flown with United Airlines from Panama City to Louisville to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,428 reviews

Entertainment

7.1

Crew

8.1

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats
United Airlines
7.4
Good
9,428 reviews
United Airlines
7.4
Good
9,428 reviews

Entertainment

7.1

Crew

8.1

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats

Related info for your journey

Find useful and relevant information for your journey from Panama City to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Louisville?

    For as low as $547, United Airlines can have you in Louisville from Panama City in 13h 27m. There are 2048 mi between Panama City and Louisville.

  • What is the cheapest airline to fly from Panama City to Louisville round-trip?

    Flying on United Airlines is currently your cheapest option to Louisville, with prices starting at $366. You may be able to fly from Panama City to Louisville for 35% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to Louisville that include hotel bookings?

    Yes. In addition to deals on Panama City to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Louisville.

  • Can I find deals for business class flights from Panama City to Louisville?

    Yes. Cheapflights offers flight deals from Panama City to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Louisville?

    Currently, August is the cheapest month in which you can book a flight from Panama City to Louisville (average of $217). Flying from Panama City to Louisville in January is currently the most expensive (average of $518). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Alternative routes for Panama City to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Nashville flights
Panama City to Cincinnati flights

Top airline flying from Panama City to Louisville

Discover the top airline that operate flights from Panama City to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$366Average$620FlexibilityNo cancel feeOn-time69%

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