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$271+ Cheap flights from Panama City (PTY) to Louisville (SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDF
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Panama City to Louisville

Cheapest flights from Panama City to Louisville
Explore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/13:30 pm
PTY
-
SDF
2 stops17h 11m
United Airlines
Mon 5/116:00 am
SDF
-
PTY
1 stop13h 37m
United Airlines
Deal found 1/27$472
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:55 am
PTY
-
SDF
1 stop12h 35m
United Airlines
Thu 5/287:05 am
SDF
-
PTY
1 stop10h 07m
United Airlines
Deal found 1/26$481
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/169:45 am
PTY
-
SDF
1 stop11h 37m
United Airlines
Sun 5/245:45 am
SDF
-
PTY
2 stops13h 52m
United Airlines
Deal found 1/27$485
This Faresmojo deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:20 pm
PTY
-
SDF
1 stop7h 34m
JetBlue
Mon 5/116:00 am
SDF
-
PTY
1 stop7h 55m
JetBlue
Deal found 1/26$572
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/64:41 pm
PTY
-
SDF
2 stops24h 08m
United Airlines
Sun 12/137:30 am
SDF
-
PTY
2 stops12h 08m
United Airlines
Deal found 1/25$581
This Mytrip deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/13:50 pm
PTY
-
SDF
3 stops26h 46m
Multiple Airlines
Sat 5/98:31 pm
SDF
-
PTY
3 stops30h 24m
Multiple Airlines
Deal found 1/25$868
This KAYAK deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:55 pm
PTY
-
SDF
1 stop16h 00m
Copa Airlines
Sat 5/96:00 am
SDF
-
PTY
1 stop13h 37m
Copa Airlines
Deal found 1/25$1,094
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/19:39 am
PTY
-
SDF
2 stops13h 20m
United Airlines
Sat 5/95:50 am
SDF
-
PTY
3 stops15h 37m
United Airlines
Deal found 1/25$5,563

Find flight deals from Panama City to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$472
(United Airlines)

One-way from

$271
(United Airlines)

Popular in

December

Cheapest in

November

Average price

$627
Provider with most accurate pricing for Panama City Tocumen Intl-Louisville Intl flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Louisville Intl flights.
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From Panama City Tocumen Intl to Louisville Intl
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One-way flight from Panama City Tocumen Intl to Louisville Intl
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($54 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Panama City to Louisville that are best for you.

Fly from

Panama City

Fly to

Louisville

Route

Depart

Return

Price

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Fri 5/1

10:55 pm-1:22 pm

2 stops13h 27m

Louisville Intl

Sat 5/9

6:00 am-2:14 pm

1 stop9h 14m

$472

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Fri 5/1

10:55 pm-1:22 pm

2 stops13h 27m

Louisville Intl

Mon 5/11

7:20 pm-2:14 pm

2 stops19h 54m

$472

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Tue 5/26

7:55 am-9:30 pm

1 stop12h 35m

Louisville Intl

Thu 5/28

7:05 am-6:37 pm

1 stop12h 32m

$481

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Fri 3/6

10:00 am-7:31 pm

1 stop9h 31m

$271

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Sun 3/8

3:41 pm-7:51 pm

1 stop27h 10m

$271

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Sat 3/7

10:55 pm-9:13 pm

2 stops22h 18m

$277

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Wed 3/4

9:45 am-8:40 am

3 stops46h 55m

$290

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Sun 3/1

2:55 am-2:38 pm

2 stops35h 43m

$308

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Thu 3/5

4:41 pm-9:59 pm

1 stop29h 18m

$318

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Wed 3/4

4:41 pm-1:17 pm

2 stops20h 36m

$318

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 12 results
1
2
  • Most accurate provider: When it comes to deals on Panama City-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Louisville

What is the cheapest month to book a flight from Panama City to Louisville?

Currently, August is the cheapest month in which you can book a flight from Panama City to Louisville (average of $217). Flying from Panama City to Louisville in January is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated January 27, 2026.
Peruse reviews from past customers who have flown with United Airlines from Panama City to Louisville to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,205 reviews

Crew

8.1

Food

6.6

Entertainment

7.1

Overall

7.4

Boarding

7.7

Comfort

7.3

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats
United Airlines
7.4
Good
9,205 reviews
United Airlines
7.4
Good
9,205 reviews

Crew

8.1

Food

6.6

Entertainment

7.1

Overall

7.4

Boarding

7.7

Comfort

7.3

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats

Related info for your journey

Find useful and relevant information for your journey from Panama City to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Louisville?

    For as low as $472, United Airlines can have you in Louisville from Panama City in 13h 27m. There are 2048 mi between Panama City and Louisville.

  • What is the cheapest airline to fly from Panama City to Louisville round-trip?

    Flying on United Airlines is currently your cheapest option to Louisville, with prices starting at $366. You may be able to fly from Panama City to Louisville for 33% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to Louisville that include hotel bookings?

    Yes. In addition to deals on Panama City to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Louisville.

  • Can I find deals for business class flights from Panama City to Louisville?

    Yes. Cheapflights offers flight deals from Panama City to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Louisville?

    Currently, August is the cheapest month in which you can book a flight from Panama City to Louisville (average of $217). Flying from Panama City to Louisville in January is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Nashville flights
Panama City to Cincinnati flights

Top airline flying from Panama City to Louisville

Discover the top airline that operate flights from Panama City to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$366Average$617FlexibilityNo cancel feeOn-time69%

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