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$331+ Cheap flights from Panama City (PTY) to Louisville (SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDF
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Panama City to Louisville

Cheapest flights from Panama City to Louisville
Explore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:55 pmPTY - SDF
2 stops20h 37mUnited Airlines
Thu 1/86:12 pmSDF - PTY
2 stops20h 33mUnited Airlines
Deal found 12/11$536
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2211:35 amPTY - SDF
2 stops22h 28mUnited Airlines
Thu 1/86:12 pmSDF - PTY
2 stops22h 55mUnited Airlines
Deal found 12/9$545
This Delta deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:00 amPTY - SDF
1 stop7h 59mDelta
Thu 1/87:05 amSDF - PTY
1 stop6h 50mDelta
Deal found 12/9$592
This Mytrip deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/212:55 amPTY - SDF
3 stops21h 04mMultiple Airlines
Thu 1/87:00 amSDF - PTY
3 stops27h 30mMultiple Airlines
Deal found 12/9$688

Find flight deals from Panama City to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$449
(United Airlines)

One-way from

$331
(Kiwi.com)

Popular in

January

Cheapest in

December

Average price

$386
Provider with most accurate pricing for Panama City Tocumen Intl-Louisville Intl flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Louisville Intl flights.
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From Panama City Tocumen Intl to Louisville Intl
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One-way flight from Panama City Tocumen Intl to Louisville Intl
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($155 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 13% potential price decrease ($70 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Panama City to Louisville that are best for you.

Fly from

Panama City

Fly to

Louisville

Route

Depart

Return

Price

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Fri 5/1

10:55 pm-10:09 pm

2 stops22h 14m

Louisville Intl

Mon 5/11

6:00 pm-4:12 pm

2 stops23h 12m

$449

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Wed 1/21

8:55 am-7:54 pm

1 stop10h 59m

Louisville Intl

Sun 1/25

8:30 am-8:02 pm

1 stop11h 32m

$510

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Wed 1/14

9:34 am-2:41 pm

2 stops29h 07m

$331

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Wed 1/14

3:20 pm-11:55 pm

1 stop8h 35m

$398

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Wed 1/14

2:27 pm-11:59 pm

1 stop9h 32m

$456

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Compare providers for flights from Panama City to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Louisville in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Louisville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Louisville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Louisville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Louisville

What is the cheapest month to book a flight from Panama City to Louisville?

Currently, December is the cheapest month in which you can book a flight from Panama City to Louisville (average of $203). Flying from Panama City to Louisville in January is currently the most expensive (average of $575). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SDF?

Find hourly flight availability from Panama City to Louisville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

One of the essential ways to save on airfare from Panama City to Louisville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 23% on airfare.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with United Airlines from Panama City to Louisville to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,095 reviews

Entertainment

7.1

Crew

8.1

Boarding

7.7

Overall

7.4

Food

6.6

Comfort

7.3

Reviews

1 / 20
8.0
Excellent

Anonymous,Dec 2025

AMS - EWR

It was good! The first 3/4 of the trip was uncomfortably cold. Only one option for lunch that I didn’t enjoy (vegetarian).
United Airlines
7.4
Good
9,095 reviews
United Airlines
7.4
Good
9,095 reviews

Entertainment

7.1

Crew

8.1

Boarding

7.7

Overall

7.4

Food

6.6

Comfort

7.3

Reviews

1 / 20
8.0
Excellent

Anonymous,Dec 2025

AMS - EWR

It was good! The first 3/4 of the trip was uncomfortably cold. Only one option for lunch that I didn’t enjoy (vegetarian).

Related info for your journey

Find useful and relevant information for your journey from Panama City to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Louisville?

    For as low as $449, United Airlines can have you in Louisville from Panama City in 22h 14m. There are 2048 mi between Panama City and Louisville.

  • What is the cheapest airline to fly from Panama City to Louisville round-trip?

    Flying on United Airlines is currently your cheapest option to Louisville, with prices starting at $188. You may be able to fly from Panama City to Louisville for 67% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to Louisville that include hotel bookings?

    Yes. In addition to deals on Panama City to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Louisville.

  • Can I find deals for business class flights from Panama City to Louisville?

    Yes. Cheapflights offers flight deals from Panama City to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Louisville?

    Currently, December is the cheapest month in which you can book a flight from Panama City to Louisville (average of $203). Flying from Panama City to Louisville in January is currently the most expensive (average of $575). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Alternative routes for Panama City to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama City to Louisville

Discover the top airline that operate flights from Panama City to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$366Average$557FlexibilityNo cancel feeOn-time69%

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