Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Columbus to Laredo as you normally would.
Located just 3.9 mi from the city center, Laredo is the airport most travelers will use when flying to Laredo from Columbus. Booking flights from Columbus to Laredo (LRD) should be relatively easy as there are 0 daily inbound flights from Columbus from 0 different airlines.