Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Durham to Lancaster, Pennsylvania as you normally would.
For a flight from Durham to Lancaster, you will be flying into Lancaster. Lancaster (LNS) is just 5.8 mi from the center of the city. Lancaster is the only Lancaster airport and it handles 0 inbound flights from Durham per day. 0 airlines have flights to Lancaster from Durham on a regular basis.