What is the cheapest airline to fly from Knoxville to La Crosse round-trip?

American Airlines, at $497, was found to be the cheapest airline from Knoxville to La Crosse..

In terms of precipitation, rainfall in La Crosse ranges from 1.1 - 4.3 inches per month. June is typically the wettest month, when rainfall can reach 4.3 in. January is typically the driest time to visit La Crosse when rainfall is around 1.1 in.

If weather is an important factor for your trip to La Crosse, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 17.6 F).

What is the cheapest time of day to fly from TYS to LSE?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to La Crosse as you normally would.

Can I find deals for flights from Knoxville to La Crosse that include hotel bookings?

Yes. In addition to deals on Knoxville to La Crosse flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to La Crosse?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to La Crosse.

Can I find deals for business class flights from Knoxville to La Crosse?

Yes. Cheapflights offers flight deals from Knoxville to La Crosse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$497+ Flights from Knoxville to La Crosse

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Cheap flight deals from Knoxville to La Crosse

Round-trip from	$497 (American Airlines)

From Knoxville McGhee Tyson to La Crosse

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Find flight deals from Knoxville to La Crosse

Cheapest flights from Knoxville to La Crosse
Explore the most affordable flight options available from Knoxville to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

jue. 9/182:34 pmTYS - LSE

2 stops9h 43mAmerican Airlines

lun. 9/226:00 amLSE - TYS

2 stops10h 43mAmerican Airlines

Deal found 7/29

$497

Best flights from Knoxville to La Crosse
Discover carefully curated flight deals from Knoxville to La Crosse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 30, 2025.

jue. 9/182:34 pmTYS - LSE

2 stops9h 43mAmerican Airlines

lun. 9/226:00 amLSE - TYS

2 stops10h 43mAmerican Airlines

Deal found 7/29

$497

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

jue. 9/18

2:34 pm-11:17 pm

2 stops9h 43m

La Crosse

lun. 9/22

6:00 am-5:43 pm

2 stops10h 43m

$497

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Knoxville to La Crosse

Have a flexible travel schedule? Discover the best time to fly to La Crosse from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing La Crosse

Read through reviews of airlines operating flights from Knoxville to La Crosse, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

2.0

Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break

American Airlines

7.2

Good

10,000 reviews

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

2.0

Mediocre

Andrew,May 2025

LAX - MIA

Related info for your journey

What is the cheapest airline to fly from Knoxville to La Crosse round-trip?
American Airlines, at $497, was found to be the cheapest airline from Knoxville to La Crosse..
Can I find deals for flights from Knoxville to La Crosse that include hotel bookings?
Yes. In addition to deals on Knoxville to La Crosse flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to La Crosse?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to La Crosse.
Can I find deals for business class flights from Knoxville to La Crosse?
Yes. Cheapflights offers flight deals from Knoxville to La Crosse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top airline flying from Knoxville to La Crosse

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$400	Average$445	FlexibilityNo cancel fee	On-time71%

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$497+ Cheap flights from Knoxville to La Crosse (TYS - LSE)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to La Crosse with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Knoxville to La Crosse

Round-trip from

Find flight deals from Knoxville to La Crosse

Cheapest flights from Knoxville to La CrosseExplore the most affordable flight options available from Knoxville to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

Explore the most affordable flight options available from Knoxville to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Best time to book a flight from Knoxville to La Crosse

Have a flexible travel schedule? Discover the best time to fly to La Crosse from Knoxville with our price prediction graph.

Reviews of airlines servicing La Crosse

Read through reviews of airlines operating flights from Knoxville to La Crosse, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What is the cheapest airline to fly from Knoxville to La Crosse round-trip?

Can I find deals for flights from Knoxville to La Crosse that include hotel bookings?

How can I find direct flights from Knoxville to La Crosse?

Can I find deals for business class flights from Knoxville to La Crosse?

Traveling to a place near La Crosse?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to La Crosse

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Knoxville to La Crosse

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Knoxville to La Crosse
Explore the most affordable flight options available from Knoxville to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.