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La Crosse

$436+ Cheap flights from Knoxville to La Crosse (TYS - LSE)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — LSE
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Knoxville to La Crosse

Cheapest flights from Knoxville to La Crosse
Explore the most affordable flight options available from Knoxville to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:33 pm
TYS
-
LSE
1 stop6h 26m
American Airlines
Tue 8/1810:53 am
LSE
-
TYS
2 stops10h 07m
American Airlines
Deal found 1/27$436
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:33 pm
TYS
-
LSE
1 stop6h 26m
American Airlines
Sat 6/611:31 am
LSE
-
TYS
1 stop5h 40m
American Airlines
Deal found 1/24$631

Find flight deals from Knoxville to La Crosse

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to La Crosse (LSE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$631
(American Airlines)
Provider with most accurate pricing for Knoxville McGhee Tyson-La Crosse flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-La Crosse flights.
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From Knoxville McGhee Tyson to La Crosse
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Fly from

Knoxville

Fly to

La Crosse

Route

Depart

Return

Price

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 6/5

11:26 am-4:55 pm

1 stop6h 29m

La Crosse

Sun 6/7

6:00 am-12:43 pm

1 stop5h 43m

$641

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Compare providers for flights from Knoxville to La Crosse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to La Crosse in January.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-La Crosse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-La Crosse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-La Crosse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-La Crosse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-La Crosse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to La Crosse

Have a flexible travel schedule? Discover the best time to fly to La Crosse from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing La Crosse

Get insights into the airlines that provide service to La Crosse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to La Crosse. Reviews last updated January 27, 2026.
Read through reviews of airlines operating flights from Knoxville to La Crosse, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,197 reviews

Overall

7.2

Food

6.4

Crew

8.0

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,197 reviews
American Airlines
7.2
Good
11,197 reviews

Overall

7.2

Food

6.4

Crew

8.0

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to La Crosse?

    For as low as $641, American Airlines can have you in La Crosse from Knoxville in 6h 29m. Knoxville and La Crosse are separated by a distance of 677 mi.

  • Can I find deals for flights from Knoxville to La Crosse that include hotel bookings?

    Yes. In addition to deals on Knoxville to La Crosse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to La Crosse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to La Crosse.

  • Can I find deals for business class flights from Knoxville to La Crosse?

    Yes. Cheapflights offers flight deals from Knoxville to La Crosse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Decorah
Winona

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Top airline flying from Knoxville to La Crosse

Discover the top airline that operate flights from Knoxville to La Crosse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$420Average$420FlexibilityNo cancel feeOn-time71%

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