How long is the flight from Knoxville to La Crosse?

For as low as $450, American Airlines can have you in La Crosse from Knoxville in 3h 57m. Knoxville and La Crosse are separated by a distance of 677 mi.

What is the cheapest airline to fly from Knoxville to La Crosse round-trip?

American Airlines, at $400, was found to be the cheapest airline from Knoxville to La Crosse..

In terms of precipitation, rainfall in La Crosse ranges from 1.1 - 4.3 inches per month. June is typically the wettest month, when rainfall can reach 4.3 in. January is typically the driest time to visit La Crosse when rainfall is around 1.1 in.

If weather is an important factor for your trip to La Crosse, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 17.6 F).

What is the cheapest time of day to fly from TYS to LSE?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to La Crosse as you normally would.

Most accurate provider : When it comes to deals on Knoxville-La Crosse flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-La Crosse flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-La Crosse flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Knoxville-La Crosse flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-La Crosse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Knoxville to La Crosse that include hotel bookings?

Yes. In addition to deals on Knoxville to La Crosse flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to La Crosse?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to La Crosse.

Can I find deals for business class flights from Knoxville to La Crosse?

Yes. Cheapflights offers flight deals from Knoxville to La Crosse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$450+ Flights from Knoxville to La Crosse

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Cheap flight deals from Knoxville to La Crosse

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$450 (American Airlines)

Provider with most accurate pricing for Knoxville McGhee Tyson-La Crosse flight deals.

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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-La Crosse flights.

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From Knoxville McGhee Tyson to La Crosse

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Find flight deals from Knoxville to La Crosse

Cheapest flights from Knoxville to La Crosse
Explore the most affordable flight options available from Knoxville to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

Tue 11/111:13 pmTYS - LSE

1 stop3h 57mAmerican Airlines

Sat 11/159:59 amLSE - TYS

1 stop5h 54mAmerican Airlines

Deal found 10/27

$450

Best flights from Knoxville to La Crosse
Discover carefully curated flight deals from Knoxville to La Crosse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 28, 2025.

Tue 11/111:13 pmTYS - LSE

1 stop3h 57mAmerican Airlines

Sat 11/159:59 amLSE - TYS

1 stop5h 54mAmerican Airlines

Deal found 10/27

$450

Last-minute flights from Knoxville to La Crosse
Discover last-minute flight deals from Knoxville to La Crosse. Data last updated October 28, 2025 and is based on user searches.

Tue 11/111:13 pmTYS - LSE

1 stop3h 57mAmerican Airlines

Sat 11/159:59 amLSE - TYS

1 stop5h 54mAmerican Airlines

Deal found 10/27

$450

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Tue 11/11

1:13 pm-4:10 pm

1 stop3h 57m

La Crosse

Sat 11/15

9:59 am-4:53 pm

1 stop5h 54m

$450

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Compare providers for flights from Knoxville to La Crosse

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to La Crosse in October.

Provider	Price Accuracy	Trust Score*
FlightHub	Price Accuracy3 stars	Trust Score*1 star
Expedia	Price Accuracy2 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Knoxville-La Crosse flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-La Crosse flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-La Crosse flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Knoxville-La Crosse flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-La Crosse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to La Crosse

Have a flexible travel schedule? Discover the best time to fly to La Crosse from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing La Crosse

Read through reviews of airlines operating flights from Knoxville to La Crosse, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,032 reviews

Reviews

1 / 20

2.0

Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

American Airlines

7.2

Good

11,032 reviews

American Airlines

7.2

Good

11,032 reviews

Reviews

1 / 20

2.0

Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

How long is the flight from Knoxville to La Crosse?
For as low as $450, American Airlines can have you in La Crosse from Knoxville in 3h 57m. Knoxville and La Crosse are separated by a distance of 677 mi.
What is the cheapest airline to fly from Knoxville to La Crosse round-trip?
American Airlines, at $400, was found to be the cheapest airline from Knoxville to La Crosse..
Can I find deals for flights from Knoxville to La Crosse that include hotel bookings?
Yes. In addition to deals on Knoxville to La Crosse flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to La Crosse?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to La Crosse.
Can I find deals for business class flights from Knoxville to La Crosse?
Yes. Cheapflights offers flight deals from Knoxville to La Crosse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Top airline flying from Knoxville to La Crosse

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$400	Average$449	FlexibilityNo cancel fee	On-time71%

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$450+ Cheap flights from Knoxville to La Crosse (TYS - LSE)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to La Crosse with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Knoxville to La Crosse

Most accurate provider

Most trusted provider

Round-trip from

Find flight deals from Knoxville to La Crosse

Cheapest flights from Knoxville to La CrosseExplore the most affordable flight options available from Knoxville to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

Explore the most affordable flight options available from Knoxville to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Compare providers for flights from Knoxville to La Crosse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to La Crosse in October.

Best time to book a flight from Knoxville to La Crosse

Have a flexible travel schedule? Discover the best time to fly to La Crosse from Knoxville with our price prediction graph.

Reviews of airlines servicing La Crosse

Read through reviews of airlines operating flights from Knoxville to La Crosse, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Knoxville to La Crosse?

What is the cheapest airline to fly from Knoxville to La Crosse round-trip?

Can I find deals for flights from Knoxville to La Crosse that include hotel bookings?

How can I find direct flights from Knoxville to La Crosse?

Can I find deals for business class flights from Knoxville to La Crosse?

Traveling to a place near La Crosse?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to La Crosse

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Knoxville to La Crosse

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Book with Flexibility

Travel Smart

Cheapest flights from Knoxville to La Crosse
Explore the most affordable flight options available from Knoxville to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.