How long is the flight from Santo Domingo to Knoxville?

There are many flights that can get you from Santo Domingo to Knoxville in 13h 57m. Fly via American Airlines to get the fastest option. Santo Domingo and Knoxville are separated by a distance of 1484 mi.

What is the cheapest airline to fly from Santo Domingo to Knoxville round-trip?

Our cheapest airline available from Santo Domingo to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $513 on this airline. You may be able to fly from Santo Domingo to Knoxville for 12% less than the average price by searching for this airline.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What is the cheapest time of day to fly from SDQ to TYS?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santo Domingo to Knoxville as you normally would.

Most accurate provider : When it comes to deals on Santo Domingo-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-Knoxville flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santo Domingo-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Santo Domingo to Knoxville that include hotel bookings?

Yes. In addition to deals on Santo Domingo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santo Domingo to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Knoxville.

Can I find deals for business class flights from Santo Domingo to Knoxville?

Yes. Cheapflights offers flight deals from Santo Domingo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$210+ Flights from Santo Domingo to Knoxville

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santo Domingo to Knoxville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$636 (American Airlines)
One-way from	$210 (Mytrip)
Popular in	May
Cheapest in	February
Average price	$552

Provider with most accurate pricing for Santo Domingo Las Americas-Knoxville McGhee Tyson flight deals.

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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Knoxville McGhee Tyson flights.

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From Santo Domingo Las Americas to Knoxville McGhee Tyson

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One-way flight from Santo Domingo Las Americas to Knoxville McGhee Tyson

Search Deals

Highest demand for flights based on searches. 14% potential increase in price ($102 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).

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Average for round-trip flights in November 2025

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Find flight deals from Santo Domingo to Knoxville

Best flights from Santo Domingo to Knoxville
Discover carefully curated flight deals from Santo Domingo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2025.

Thu 2/1911:02 amSDQ - TYS

1 stop13h 57mAmerican Airlines

Sun 2/226:00 amTYS - SDQ

1 stop10h 48mAmerican Airlines

Deal found 11/10

$636

One-way flights from Santo Domingo to Knoxville
Search for one-way flight options from Santo Domingo to Knoxville. Find affordable one-way fares based on user searches. Data last updated November 13, 2025.

Sat 12/64:21 pmSDQ - TYS

2 stops20h 10mMultiple Airlines

Deal found 11/12

$210

Tue 5/127:00 amSDQ - TYS

2 stops14h 44mDelta

Deal found 11/11

$324

Sat 12/64:58 pmSDQ - TYS

1 stop7h 59mAmerican Airlines

Deal found 11/11

$334

Mon 11/243:05 pmSDQ - TYS

1 stop9h 54mAmerican Airlines

Deal found 11/11

$340

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 2/19

11:02 am-11:59 pm

1 stop13h 57m

Knoxville McGhee Tyson

Sun 2/22

6:00 am-5:48 pm

1 stop10h 48m

$636

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 12/6

4:21 pm-3:57 pm

3 stops24h 36m

$234

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Tue 5/12

2:45 pm-9:44 pm

1 stop6h 59m

$324

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 12/6

6:35 am-6:58 pm

2 stops13h 23m

$324

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 12/6

6:00 am-4:33 pm

1 stop11h 33m

$335

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 11/24

3:05 pm-11:59 pm

1 stop9h 54m

$340

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/13

Compare providers for flights from Santo Domingo to Knoxville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Knoxville in November.

Provider	Price Accuracy	Trust Score*
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santo Domingo-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-Knoxville flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santo Domingo-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santo Domingo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get a feel of what it's like to fly with American Airlines from Santo Domingo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,051 reviews

Reviews

1 / 20

8.0

Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.

American Airlines

7.2

Good

11,051 reviews

American Airlines

7.2

Good

11,051 reviews

Reviews

1 / 20

8.0

Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.

Related info for your journey

How long is the flight from Santo Domingo to Knoxville?
There are many flights that can get you from Santo Domingo to Knoxville in 13h 57m. Fly via American Airlines to get the fastest option. Santo Domingo and Knoxville are separated by a distance of 1484 mi.
What is the cheapest airline to fly from Santo Domingo to Knoxville round-trip?
Our cheapest airline available from Santo Domingo to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $513 on this airline. You may be able to fly from Santo Domingo to Knoxville for 12% less than the average price by searching for this airline.
Can I find deals for flights from Santo Domingo to Knoxville that include hotel bookings?
Yes. In addition to deals on Santo Domingo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santo Domingo to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Knoxville.
Can I find deals for business class flights from Santo Domingo to Knoxville?
Yes. Cheapflights offers flight deals from Santo Domingo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Morristown

Cherokee

Crossville

Corbin

Bryson City

Alcoa

Oak Ridge

Murphy

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Top airline flying from Santo Domingo to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$513	Average$517	FlexibilityNo cancel fee	On-time71%

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$210+ Cheap flights from Santo Domingo (SDQ) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santo Domingo to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Santo Domingo to Knoxville

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Santo Domingo to Knoxville

Best flights from Santo Domingo to KnoxvilleDiscover carefully curated flight deals from Santo Domingo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2025.

Discover carefully curated flight deals from Santo Domingo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Compare providers for flights from Santo Domingo to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Knoxville in November.

Best time to book a flight from Santo Domingo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santo Domingo with our price prediction graph.

Reviews of airlines servicing Knoxville

Get a feel of what it's like to fly with American Airlines from Santo Domingo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Santo Domingo to Knoxville?

What is the cheapest airline to fly from Santo Domingo to Knoxville round-trip?

Can I find deals for flights from Santo Domingo to Knoxville that include hotel bookings?

How can I find direct flights from Santo Domingo to Knoxville?

Can I find deals for business class flights from Santo Domingo to Knoxville?

Traveling to a place near Knoxville?

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Alternative routes for Santo Domingo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Santo Domingo to Knoxville

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Book with Flexibility

Travel Smart

Best flights from Santo Domingo to Knoxville
Discover carefully curated flight deals from Santo Domingo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2025.