$134+ Cheap flights from Portland to Knoxville (PDX - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
PDX — TYS
Mar 13 — Mar 201
1 adult, Economy
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Find cheap flights from Portland to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to Knoxville
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Best
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Cheapest flights from Portland to KnoxvilleExplore the most affordable flight options available from Portland to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.
Explore the most affordable flight options available from Portland to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:48 pm
PDX
- TYS
1 stop22h 45m
Multiple Airlines
Mon 5/41:43 pm
TYS
- PDX
2 stops26h 19m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$326
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/229:59 am
PDX
- TYS
1 stop10h 54m
American Airlines
Sat 8/295:35 am
TYS
- PDX
1 stop16h 18m
American Airlines
Deal found 2/8![American Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/131:48 pm
PDX
- TYS
1 stop22h 45m
Multiple Airlines
Mon 5/181:15 pm
TYS
- PDX
2 stops26h 47m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:22 am
PDX
- TYS
1 stop11h 59m
American Airlines
Tue 4/2111:31 am
TYS
- PDX
1 stop14h 11m
American Airlines
Deal found 2/8![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:59 pm
PDX
- TYS
1 stop7h 20m
United Airlines
Tue 3/174:18 pm
TYS
- PDX
1 stop7h 52m
United Airlines
Deal found 2/10![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:40 pm
PDX
- TYS
1 stop7h 46m
American Airlines
Sat 5/27:50 am
TYS
- PDX
1 stop9h 34m
American Airlines
Deal found 2/11![American Airlines logo]()
$363
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/912:30 am
PDX
- TYS
2 stops13h 13m
Delta
Tue 3/175:40 am
TYS
- PDX
2 stops10h 08m
Delta
Deal found 2/10![Delta logo]()
$370
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:55 pm
PDX
- TYS
1 stop8h 13m
United Airlines
Tue 4/212:25 pm
TYS
- PDX
1 stop9h 17m
United Airlines
Deal found 2/9![United Airlines logo]()
$372
Best flights from Portland to KnoxvilleDiscover carefully curated flight deals from Portland to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 11, 2026.
Discover carefully curated flight deals from Portland to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:48 pm
PDX
- TYS
1 stop22h 45m
Multiple Airlines
Mon 5/41:43 pm
TYS
- PDX
2 stops26h 19m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$326
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:59 pm
PDX
- TYS
1 stop7h 20m
United Airlines
Tue 3/174:18 pm
TYS
- PDX
1 stop7h 52m
United Airlines
Deal found 2/10![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:47 pm
PDX
- TYS
1 stop8h 31m
American Airlines
Sat 5/23:58 pm
TYS
- PDX
2 stops9h 59m
American Airlines
Deal found 2/9![American Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/212:40 am
PDX
- TYS
2 stops11h 35m
Delta
Wed 3/1811:18 am
TYS
- PDX
2 stops12h 07m
Delta
Deal found 2/10![Delta logo]()
$380
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:59 pm
PDX
- TYS
1 stop7h 13m
United Airlines
Wed 3/187:05 am
TYS
- PDX
1 stop8h 30m
United Airlines
Deal found 2/10![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:06 pm
PDX
- TYS
2 stops10h 21m
Delta
Tue 5/123:00 pm
TYS
- PDX
1 stop9h 40m
Delta
Deal found 2/10![Delta logo]()
$387
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:50 am
PDX
- TYS
1 stop8h 48m
United Airlines
Sat 4/187:00 am
TYS
- PDX
1 stop7h 44m
United Airlines
Deal found 2/11![United Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:55 pm
PDX
- TYS
1 stop8h 13m
United Airlines
Tue 4/212:25 pm
TYS
- PDX
1 stop9h 17m
United Airlines
Deal found 2/9![United Airlines logo]()
$372
Last-minute flights from Portland to KnoxvilleDiscover last-minute flight deals from Portland to Knoxville. Data last updated February 11, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Knoxville. Data last updated February 11, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/212:40 am
PDX
- TYS
2 stops11h 35m
Delta
Wed 3/1811:18 am
TYS
- PDX
2 stops12h 07m
Delta
Deal found 2/10![Delta logo]()
$380
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/212:04 pm
PDX
- TYS
1 stop9h 24m
American Airlines
Mon 3/94:29 pm
TYS
- PDX
1 stop9h 40m
American Airlines
Deal found 2/9![American Airlines logo]()
$385
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:57 pm
PDX
- TYS
2 stops11h 15m
United Airlines
Mon 3/94:18 pm
TYS
- PDX
1 stop7h 52m
United Airlines
Deal found 2/8![United Airlines logo]()
$390
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/711:35 pm
PDX
- TYS
1 stop7h 10m
American Airlines
Sat 3/146:21 pm
TYS
- PDX
1 stop7h 45m
American Airlines
Deal found 2/8![American Airlines logo]()
$411
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/712:09 pm
PDX
- TYS
1 stop8h 43m
Delta
Sat 3/145:40 am
TYS
- PDX
1 stop7h 50m
Delta
Deal found 2/11![Delta logo]()
$416
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/912:30 am
PDX
- TYS
2 stops13h 13m
Delta
Tue 3/175:40 am
TYS
- PDX
2 stops10h 08m
Delta
Deal found 2/10![Delta logo]()
$370
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:59 pm
PDX
- TYS
1 stop7h 20m
United Airlines
Tue 3/174:18 pm
TYS
- PDX
1 stop7h 52m
United Airlines
Deal found 2/10![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/1611:59 pm
PDX
- TYS
1 stop8h 31m
American Airlines
Tue 3/314:29 pm
TYS
- PDX
1 stop8h 33m
American Airlines
Deal found 2/10![American Airlines logo]()
$394
One-way flights from Portland to KnoxvilleSearch for one-way flight options from Portland to Knoxville. Find affordable one-way fares based on user searches. Data last updated February 11, 2026.
Search for one-way flight options from Portland to Knoxville. Find affordable one-way fares based on user searches. Data last updated February 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:48 pm
PDX
- TYS
1 stop22h 45m
Frontier
Deal found 2/9![Frontier logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:48 pm
PDX
- TYS
1 stop22h 45m
Frontier
Deal found 2/9![Frontier logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:48 pm
PDX
- TYS
3 stops28h 02m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:48 am
PDX
- TYS
3 stops48h 53m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$178
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:00 am
PDX
- TYS
1 stop9h 04m
American Airlines
Deal found 2/10![American Airlines logo]()
$180
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:47 pm
PDX
- TYS
2 stops10h 28m
American Airlines
Deal found 2/9![American Airlines logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:48 am
PDX
- TYS
2 stops32h 03m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$187
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/1611:59 pm
PDX
- TYS
1 stop7h 20m
United Airlines
Deal found 2/10![United Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/249:43 am
PDX
- TYS
3 stops58h 16m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:48 pm
PDX
- TYS
3 stops29h 09m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$209
Find flight deals from Portland to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Portland (PDX) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $326 (Kiwi.com) |
One-way from | $134 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $448 |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.
Fly from
Portland
Fly to
Knoxville
Route
Depart
Return
Price
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Wed 4/29
1:48 pm-3:33 pm
1 stop22h 45m
Knoxville McGhee Tyson
Mon 5/4
1:43 pm-1:02 pm
2 stops26h 19m
$326
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Tue 3/10
11:59 pm-10:19 am
1 stop7h 20m
Knoxville McGhee Tyson
Tue 3/17
4:18 pm-9:10 pm
1 stop7h 52m
$359
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Tue 3/3
11:59 pm-10:12 am
1 stop7h 13m
Knoxville McGhee Tyson
Wed 3/18
7:05 am-12:35 pm
1 stop8h 30m
$359
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Tue 4/14
10:50 am-10:38 pm
1 stop8h 48m
Knoxville McGhee Tyson
Sat 4/18
7:00 am-11:44 am
1 stop7h 44m
$363
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Tue 4/28
11:47 pm-11:18 am
1 stop8h 31m
Knoxville McGhee Tyson
Sat 5/2
3:58 pm-10:57 pm
2 stops9h 59m
$368
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Thu 4/16
10:55 pm-10:08 am
1 stop8h 13m
Knoxville McGhee Tyson
Tue 4/21
2:25 pm-8:42 pm
1 stop9h 17m
$372
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Mon 3/2
12:40 am-3:15 pm
2 stops11h 35m
Knoxville McGhee Tyson
Wed 3/18
11:18 am-8:25 pm
2 stops12h 07m
$380
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Mon 5/11
8:06 pm-9:27 am
2 stops10h 21m
Knoxville McGhee Tyson
Tue 5/12
3:00 pm-9:40 pm
1 stop9h 40m
$387
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Wed 5/6
1:48 pm-3:33 pm
1 stop22h 45m
$134
PortlandKnoxville
PDX - TYS
PDXTYS
Portland
Wed 4/29
1:48 pm-3:33 pm
1 stop22h 45m
$142
Showing 1-10 of 18 results
Compare providers for flights from Portland to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Knoxville in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Portland-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Portland-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Portland to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Portland with our price prediction graph.
PDX-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to Knoxville
How far ahead should I book a flight from Portland to Knoxville?
Use this chart to determine the optimal time to book a round-trip flight from Portland to Knoxville. Price data was last updated on February 6, 2026.
The best time to book flights from Portland to Knoxville is 75 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Portland to Knoxville?
Currently, July is the cheapest month in which you can book a flight from Portland to Knoxville (average of $126). Flying from Portland to Knoxville in May is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 11, 2026.
Read through reviews of airlines operating flights from Portland to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Portland to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy
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Find flights from Portland to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 11, 2026.
Portland and Knoxville flights
Browse other Portland and Knoxville flight options. Last updated on February 11, 2026.
Other flights from Portland
Browse through other flights departing from Portland. Flights are based on user searches made on Cheapflights and were last updated on February 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Portland to Knoxville
Discover the top 4 airlines that operate flights from Portland to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$240 | Average$326 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$248 | Average$462 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$268 | Average$429 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$298 | Average$459 | FlexibilityNo cancel fee | On-time71% |