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$135+ Cheap flights from Portland to Knoxville (PDX - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
PDX — TYS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Portland to Knoxville McGhee Tyson are usually found in February or August, booked 75 days in advance, depart on a Tuesday or Wednesday and return on a Wednesday

Cheap flight deals from Portland to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Portland (PDX) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$247
(Kiwi.com)

One-way from

$135
(American Airlines)

Popular in

December

Cheapest in

February

Average price

$419
From Portland to Knoxville McGhee Tyson
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One-way flight from Portland to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 7% potential increase in price ($37 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Portland to Knoxville

Cheapest flights from Portland to Knoxville
Explore the most affordable flight options available from Portland to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1111:45 amPDX - TYS
1 stop7h 37mMultiple Airlines
Sun 12/146:30 amTYS - PDX
1 stop8h 27mMultiple Airlines
Deal found 9/14$247
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/511:26 amPDX - TYS
1 stop8h 56mDelta
Wed 11/123:51 pmTYS - PDX
1 stop9h 30mDelta
Deal found 9/16$269
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:15 pmPDX - TYS
1 stop9h 48mDelta
Tue 11/185:25 amTYS - PDX
2 stops10h 23mDelta
Deal found 9/16$274
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:15 amPDX - TYS
1 stop27h 18mMultiple Airlines
Sun 10/55:44 pmTYS - PDX
2 stops45h 04mMultiple Airlines
Deal found 9/16$291
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/55:00 amPDX - TYS
1 stop6h 43mUnited Airlines
Wed 11/125:45 amTYS - PDX
2 stops11h 02mUnited Airlines
Deal found 9/16$293
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1811:59 pmPDX - TYS
1 stop8h 45mAmerican Airlines
Wed 10/226:43 pmTYS - PDX
1 stop7h 46mAmerican Airlines
Deal found 9/15$294
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1510:10 pmPDX - TYS
1 stop8h 27mDelta
Sat 11/223:51 pmTYS - PDX
1 stop9h 30mDelta
Deal found 9/16$299
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/155:30 amPDX - TYS
2 stops10h 30mDelta
Thu 11/203:51 pmTYS - PDX
1 stop9h 30mDelta
Deal found 9/16$304
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:15 pmPDX - TYS
2 stops10h 08mDelta
Wed 11/195:25 amTYS - PDX
2 stops10h 23mDelta
Deal found 9/16$309
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:15 amPDX - TYS
1 stop27h 18mMultiple Airlines
Thu 10/97:00 amTYS - PDX
1 stop7h 38mMultiple Airlines
Deal found 9/15$311

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Portland

Fly to

Knoxville

Route

Depart

Return

Price

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Mon 11/17

12:35 am-2:46 pm

2 stops11h 11m

Knoxville McGhee Tyson

Wed 11/19

5:25 am-12:48 pm

2 stops10h 23m

$279

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 11/18

11:15 pm-12:03 pm

1 stop9h 48m

Knoxville McGhee Tyson

Sat 11/22

3:51 pm-10:21 pm

1 stop9h 30m

$299

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Fri 11/14

11:15 pm-12:23 pm

2 stops10h 08m

Knoxville McGhee Tyson

Tue 11/18

6:29 am-12:48 pm

1 stop9h 19m

$304

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 11/15

10:10 pm-9:37 am

1 stop8h 27m

Knoxville McGhee Tyson

Fri 11/21

5:25 am-12:48 pm

2 stops10h 23m

$334

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 2/21

9:45 pm-9:13 am

1 stop8h 28m

Knoxville McGhee Tyson

Wed 2/25

11:30 am-8:30 pm

2 stops12h 00m

$334

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Fri 11/14

11:15 pm-12:23 pm

2 stops10h 08m

Knoxville McGhee Tyson

Sat 11/22

3:51 pm-10:21 pm

1 stop9h 30m

$334

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 11/19

12:00 pm-12:08 am

1 stop9h 08m

$135

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 10/29

2:05 pm-12:23 am

1 stop7h 18m

$135

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 10/28

12:40 am-1:42 pm

2 stops10h 02m

$140

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 11/19

5:30 am-7:00 pm

2 stops10h 30m

$140

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 12 results
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Best time to book a flight from Portland to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Knoxville

How far ahead should I book a flight from Portland to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Portland to Knoxville. Price data was last updated on September 12, 2025.

The best time to book flights from Portland to Knoxville is 75 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Portland to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Portland to Knoxville (average of $295). Flying from Portland to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PDX to TYS?

Find hourly flight availability from Portland to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from Portland to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 4% versus a flight in the afternoon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Portland to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.8
Fair
3,173 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Portland to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Portland to Knoxville?

    For as low as $279, Delta can have you in Knoxville from Portland in 11h 11m. There are 2107 mi between Portland and Knoxville.

  • What are the cheapest airlines flying from Portland to Knoxville round-trip?

    Cheapflights users have booked flights from Portland to Knoxville round-trip from $157. Other airlines that can offer you cheap pricing are United Airlines, from $258, and American Airlines, from $293. Frontier is 66% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Portland to Knoxville that include hotel bookings?

    Yes. In addition to deals on Portland to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Knoxville.

  • Can I find deals for business class flights from Portland to Knoxville?

    Yes. Cheapflights offers flight deals from Portland to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Portland to Knoxville (average of $295). Flying from Portland to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 4 airlines flying from Portland to Knoxville

Discover the top 4 airlines that operate flights from Portland to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$157Average$273FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$258Average$488FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$293Average$466FlexibilityNo cancel feeOn-time71%
DeltaCheapest$308Average$471FlexibilityNo cancel feeOn-timeN/A

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