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$440+ Cheap flights from Cape Cod and the Islands to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/14. Fares are subject to change and may not be available on all flights or dates of travel.
MVY — TYS
May 3 — May 101
Sun 5/3
Sun 5/10
1 adult, Economy
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Cheap flight deals from Cape Cod and the Islands to Knoxville

Cheapest flights from Cape Cod and the Islands to Knoxville
Explore the most affordable flight options available from Cape Cod and the Islands to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.

This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:42 am
MVY
-
TYS
1 stop4h 56m
Delta
Mon 7/206:00 am
TYS
-
MVY
1 stop5h 01m
Delta
Deal found 3/30$440
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/811:42 am
MVY
-
TYS
1 stop5h 01m
Delta
Wed 6/106:00 am
TYS
-
MVY
1 stop5h 02m
Delta
Deal found 3/31$644

Find flight deals from Cape Cod and the Islands to Knoxville

Keep the following information in mind while searching for Cape Cod and the Islands to Knoxville flight deals. Data was last updated April 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$440
(Delta)

Popular in

March

Cheapest in

February

Average price

$340
Provider with most accurate pricing for Boston Logan Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Boston Logan Intl-Knoxville McGhee Tyson flights.
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From Cape Cod and the Islands to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($7 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Cape Cod and the Islands to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Cape Cod and the Islands to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

West TisburyKnoxville

MVY - TYS

MVYTYS

West Tisbury Martha's Vineyard

Tue 7/14

11:42 am-4:38 pm

1 stop4h 56m

Knoxville McGhee Tyson

Mon 7/20

6:00 am-11:01 am

1 stop5h 01m

$440

West TisburyKnoxville

MVY - TYS

MVYTYS

West Tisbury Martha's Vineyard

Mon 6/8

11:42 am-4:43 pm

1 stop5h 01m

Knoxville McGhee Tyson

Wed 6/10

6:00 am-11:02 am

1 stop5h 02m

$644

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Sorted by cheapest first

Best time to book a flight from Cape Cod and the Islands to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Cape Cod and the Islands with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cape Cod and the Islands to Knoxville
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Cape Cod and the Islands to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Cape Cod and the Islands?

    If you book a flight to Knoxville from Cape Cod and the Islands, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Cape Cod and the Islands to Knoxville?

    Departing from Cape Cod and the Islands to Knoxville will take you 4h 56m. Cape Cod and the Islands and Knoxville are separated by a distance of 817 mi.

  • Can I find deals for flights from Cape Cod and the Islands to Knoxville that include hotel bookings?

    Yes. In addition to deals on Cape Cod and the Islands to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cape Cod and the Islands to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cape Cod and the Islands to Knoxville.

  • Can I find deals for business class flights from Cape Cod and the Islands to Knoxville?

    Yes. Cheapflights offers flight deals from Cape Cod and the Islands to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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