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Key Largo

$122+ Cheap flights from San Diego (SAN) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — MIA
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from San Diego to Key Largo are usually found in January or April, booked 68 days in advance, depart on a Wednesday or Friday and return on a Wednesday

Cheap flight deals from San Diego to Key Largo

Keep the following information in mind while searching for San Diego to Key Largo flight deals. Data was last updated September 15, 2025.

Round-trip from

$248
(Kiwi.com)

One-way from

$122
(United Airlines)

Popular in

December

Cheapest in

January

Average price

$423
From San Diego to Key Largo
Search Deals
One-way flight from San Diego to Key Largo
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from San Diego to Key Largo

Cheapest flights from San Diego to Key Largo
Explore the most affordable flight options available from San Diego to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2310:52 amSAN - MIA
1 stop16h 27mFrontier
Mon 10/278:00 amMIA - SAN
2 stops18h 04mFrontier
Deal found 9/14$248
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:35 amSAN - MIA
1 stop15h 09mMultiple Airlines
Mon 9/293:50 pmMIA - SAN
2 stops23h 41mMultiple Airlines
Deal found 9/13$249
This CheapOair deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/109:03 pmSAN - MIA
1 stop16h 11mFrontier
Mon 10/136:00 amMIA - SAN
1 stop20h 50mFrontier
Deal found 9/13$251
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2910:30 pmSAN - MIA
1 stop10h 19mUnited Airlines
Tue 11/44:50 pmMIA - SAN
1 stop8h 03mUnited Airlines
Deal found 9/13$252
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:35 amSAN - MIA
2 stops14h 37mFrontier
Sun 10/56:00 amMIA - SAN
1 stop8h 09mFrontier
Deal found 9/13$253
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/112:24 pmSAN - MIA
2 stops15h 30mMultiple Airlines
Sat 10/186:00 amMIA - SAN
1 stop10h 28mMultiple Airlines
Deal found 9/13$254
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/910:35 pmSAN - MIA
Nonstop4h 48mAmerican Airlines
Tue 12/167:15 amMIA - SAN
1 stop11h 04mAmerican Airlines
Deal found 9/14$255
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/28:25 amSAN - MIA
2 stops12h 34mMultiple Airlines
Sun 10/56:00 amMIA - SAN
1 stop8h 09mMultiple Airlines
Deal found 9/13$256
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:20 amSAN - MIA
1 stop8h 48mDelta
Mon 11/247:40 amMIA - SAN
1 stop10h 44mDelta
Deal found 9/14$257
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/112:30 pmSAN - MIA
Nonstop4h 53mAmerican Airlines
Wed 11/57:10 amMIA - SAN
1 stop11h 06mAmerican Airlines
Deal found 9/14$260
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2512:04 pmSAN - MIA
1 stop9h 40mMultiple Airlines
Sun 9/286:00 amMIA - SAN
2 stops28h 29mMultiple Airlines
Deal found 9/14$261

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from San Diego to Key Largo that are best for you.

Fly from

San Diego

Fly to

Key Largo

Route

Depart

Return

Price

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Wed 10/29

10:30 pm-11:49 am

1 stop10h 19m

Miami

Tue 11/4

4:50 pm-9:53 pm

1 stop8h 03m

$252

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Sat 10/18

7:25 am-9:27 pm

1 stop11h 02m

Miami

Fri 10/24

6:45 pm-11:58 pm

1 stop8h 13m

$257

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Tue 12/16

7:07 pm-6:25 am

1 stop8h 18m

Miami

Tue 2/10

6:00 am-1:18 pm

1 stop10h 18m

$257

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Tue 10/7

10:15 pm-11:16 am

1 stop10h 01m

Miami

Sat 10/11

4:17 pm-10:14 pm

1 stop8h 57m

$257

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Sat 10/11

7:25 am-9:27 pm

1 stop11h 02m

Miami

Sat 10/18

8:30 am-2:32 pm

1 stop9h 02m

$257

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Tue 11/18

7:06 pm-6:25 am

1 stop8h 19m

Miami

Mon 11/24

7:40 am-3:24 pm

1 stop10h 44m

$257

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Mon 11/24

9:10 pm-3:57 pm

1 stop15h 47m

Miami

Tue 12/2

5:00 pm-9:49 am

1 stop19h 49m

$294

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Fri 1/30

6:15 am-5:14 pm

1 stop7h 59m

Miami

Mon 2/9

8:00 am-3:22 pm

1 stop10h 22m

$308

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Tue 12/30

10:30 pm-9:27 am

1 stop7h 57m

Miami

Thu 1/8

8:00 am-3:22 pm

1 stop10h 22m

$308

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Sun 11/16

10:00 pm-11:07 am

1 stop10h 07m

Miami

Sat 11/22

8:05 am-2:15 pm

1 stop9h 10m

$312

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 21 results
1
2
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Best time to book a flight from San Diego to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Key Largo

How far ahead should I book a flight from San Diego to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from San Diego to Key Largo. Price data was last updated on September 12, 2025.

Booking 68 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Key Largo. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Diego to Key Largo?

Currently, September is the cheapest month in which you can book a flight from San Diego to Key Largo (average of $232). Flying from San Diego to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to KE9?

Find hourly flight availability from San Diego to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from San Diego to Key Largo as you normally would.

What is the cheapest day to fly from San Diego to Key Largo?

Use this chart to determine the cheapest time to fly round-trip from San Diego to Key Largo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Diego to Key Largo flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from San Diego to Key Largo

Explore weekly flight availability from San Diego to Key Largo. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 15, 2025.

The most flights from SAN to KE9 are scheduled on a Monday (2 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated September 15, 2025.
See what other customers who have flown with Alaska Airlines, Delta, and American Airlines from San Diego to Key Largo have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Entertainment

7.0

Comfort

7.8

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Entertainment

7.0

Comfort

7.8

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
8.0
Very good
7,956 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Entertainment

7.0

Comfort

7.8

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Entertainment

7.0

Comfort

7.8

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Spirit Airlines
6.3
Okay
8,016 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Entertainment

7.0

Comfort

7.8

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,173 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Entertainment

7.0

Comfort

7.8

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Diego to Key Largo?

    San Diego (SAN), located 2.6 mi from the city center, is the airport you fly out of when you book flights from San Diego to Key Largo. 9 airlines have flights from San Diego to Key Largo on a regular basis. Booking flights from San Diego to Key Largo should not be difficult; the airport handles an average of 2 outbound flights to Key Largo per day.

  • How popular is this San Diego to Key Largo flight route?

    The San Diego to Key Largo flight path was viewed by 11 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from San Diego to Key Largo?

    United Airlines and Delta can get you from San Diego to Key Largo in just under 10h 19m. Your travel time can differ by up to 43m. The distance between San Diego and Key Largo is about 2262 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most reliable airlines from San Diego to Key Largo?

    Before booking your flight to Key Largo from San Diego, check out the most reliable airlines to get you to your destination on time: American Airlines (85%), Alaska Airlines (85%), GOL( 83%).

  • What are the cheapest flights from San Diego to Key Largo?

    The cheapest flight price from San Diego to Key Largo is $121. On average you can expect to pay $1,114. The most popular route, (San Diego - Miami), can usually be booked for $164.

  • Can I find deals for flights from San Diego to Key Largo that include hotel bookings?

    Yes. In addition to deals on San Diego to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Key Largo.

  • Can I find deals for business class flights from San Diego to Key Largo?

    Yes. Cheapflights offers flight deals from San Diego to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Key Largo?

    Currently, September is the cheapest month in which you can book a flight from San Diego to Key Largo (average of $232). Flying from San Diego to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 9 airlines flying from San Diego to Key Largo

Discover the top 9 airlines that operate flights from San Diego to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$89Average$203FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$107Average$213FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$216Average$450FlexibilityNo cancel feeOn-time71%
JetBlueCheapest$218Average$505FlexibilityNo cancel feeOn-time62%
Alaska AirlinesCheapest$237Average$517FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$244Average$427FlexibilityNo cancel feeOn-time69%
DeltaCheapest$256Average$372FlexibilityNo cancel feeOn-timeN/A
Hawaiian AirlinesCheapest$267Average$367FlexibilityNo cancel feeOn-time85%
SouthwestCheapest$280Average$497FlexibilityNo cancel feeOn-time63%

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