$93+ Cheap flights from Portland, ME (PWM) to Key Largo, FL
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — MIA
Apr 23 — Apr 301
Round-trip
1 adult, Economy
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Find cheap flights from Portland to Key Largo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to Key Largo
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Best
Last-minute
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Cheapest flights from Portland to Key LargoExplore the most affordable flight options available from Portland to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.
Explore the most affordable flight options available from Portland to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:39 pm
PWM
- MIA
1 stop6h 17m
American Airlines
Wed 4/155:20 pm
MIA
- PWM
1 stop6h 07m
American Airlines
Deal found 3/23![American Airlines logo]()
$201
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:50 pm
PWM
- MIA
1 stop6h 10m
Southwest
Wed 4/154:50 pm
MIA
- PWM
1 stop5h 45m
Southwest
Deal found 3/23![Southwest logo]()
$203
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:50 pm
PWM
- MIA
1 stop8h 10m
Southwest
Thu 4/166:25 pm
MIA
- PWM
1 stop5h 00m
Southwest
Deal found 3/23![Southwest logo]()
$220
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:23 pm
PWM
- MIA
1 stop5h 36m
American Airlines
Wed 4/295:20 pm
MIA
- PWM
1 stop6h 07m
American Airlines
Deal found 3/23![American Airlines logo]()
$235
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:21 am
PWM
- MIA
1 stop8h 51m
Delta
Fri 5/83:35 pm
MIA
- PWM
1 stop9h 08m
Delta
Deal found 3/23![Delta logo]()
$277
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:56 am
PWM
- MIA
1 stop6h 46m
American Airlines
Sun 5/246:45 am
MIA
- PWM
1 stop5h 32m
American Airlines
Deal found 3/23![American Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/124:20 pm
PWM
- MIA
1 stop6h 25m
Southwest
Thu 4/161:50 pm
MIA
- PWM
2 stops9h 35m
Southwest
Deal found 3/22![Southwest logo]()
$282
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/55:30 am
PWM
- MIA
2 stops10h 10m
Southwest
Thu 4/96:05 am
MIA
- PWM
2 stops8h 05m
Southwest
Deal found 3/21![Southwest logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:01 pm
PWM
- MIA
1 stop17h 26m
Multiple Airlines
Wed 5/135:22 pm
MIA
- PWM
2 stops25h 54m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$292
Best flights from Portland to Key LargoDiscover carefully curated flight deals from Portland to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 24, 2026.
Discover carefully curated flight deals from Portland to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 24, 2026.
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:50 pm
PWM
- MIA
1 stop8h 10m
Southwest
Thu 4/166:25 pm
MIA
- PWM
1 stop5h 00m
Southwest
Deal found 3/23![Southwest logo]()
$220
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:20 am
PWM
- MIA
1 stop6h 56m
United Airlines
Wed 5/612:10 pm
MIA
- PWM
1 stop9h 09m
United Airlines
Deal found 3/23![United Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:57 pm
PWM
- MIA
1 stop5h 58m
Delta
Fri 8/78:01 am
MIA
- PWM
1 stop8h 00m
Delta
Deal found 3/23![Delta logo]()
$338
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:30 am
PWM
- MIA
2 stops9h 50m
Southwest
Thu 6/46:50 pm
MIA
- PWM
1 stop5h 15m
Southwest
Deal found 3/21![Southwest logo]()
$282
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/99:20 am
PWM
- MIA
1 stop6h 56m
United Airlines
Wed 5/136:10 pm
MIA
- PWM
1 stop5h 49m
United Airlines
Deal found 3/19![United Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/223:55 pm
PWM
- MIA
1 stop5h 15m
Southwest
Wed 4/2912:10 pm
MIA
- PWM
2 stops10h 25m
Southwest
Deal found 3/23![Southwest logo]()
$403
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/53:10 pm
PWM
- MIA
1 stop8h 05m
Southwest
Sun 6/146:20 am
MIA
- PWM
1 stop10h 40m
Southwest
Deal found 3/21![Southwest logo]()
$437
Last-minute flights from Portland to Key LargoDiscover last-minute flight deals from Portland to Key Largo. Data last updated March 24, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Key Largo. Data last updated March 24, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/55:30 am
PWM
- MIA
2 stops10h 10m
Southwest
Thu 4/96:05 am
MIA
- PWM
2 stops8h 05m
Southwest
Deal found 3/21![Southwest logo]()
$287
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/114:35 pm
PWM
- MIA
1 stop6h 40m
Southwest
Sat 4/186:35 am
MIA
- PWM
1 stop5h 20m
Southwest
Deal found 3/21![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/124:20 pm
PWM
- MIA
1 stop6h 25m
Southwest
Thu 4/161:50 pm
MIA
- PWM
2 stops9h 35m
Southwest
Deal found 3/22![Southwest logo]()
$282
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:39 pm
PWM
- MIA
1 stop6h 17m
American Airlines
Wed 4/155:20 pm
MIA
- PWM
1 stop6h 07m
American Airlines
Deal found 3/23![American Airlines logo]()
$201
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:50 pm
PWM
- MIA
1 stop6h 10m
Southwest
Wed 4/154:50 pm
MIA
- PWM
1 stop5h 45m
Southwest
Deal found 3/23![Southwest logo]()
$203
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:50 pm
PWM
- MIA
1 stop8h 10m
Southwest
Thu 4/166:25 pm
MIA
- PWM
1 stop5h 00m
Southwest
Deal found 3/23![Southwest logo]()
$220
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:23 pm
PWM
- MIA
1 stop5h 36m
American Airlines
Wed 4/295:20 pm
MIA
- PWM
1 stop6h 07m
American Airlines
Deal found 3/23![American Airlines logo]()
$235
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:23 pm
PWM
- MIA
1 stop5h 36m
American Airlines
Thu 4/303:40 pm
MIA
- PWM
1 stop7h 06m
American Airlines
Deal found 3/23![American Airlines logo]()
$295
One-way flights from Portland to Key LargoSearch for one-way flight options from Portland to Key Largo. Find affordable one-way fares based on user searches. Data last updated March 24, 2026.
Search for one-way flight options from Portland to Key Largo. Find affordable one-way fares based on user searches. Data last updated March 24, 2026.
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:00 pm
PWM
- MIA
1 stop8h 10m
Southwest
Deal found 3/22![Southwest logo]()
$93
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
PWM
- MIA
1 stop7h 55m
Delta
Deal found 3/23![Delta logo]()
$110
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:23 pm
PWM
- MIA
1 stop5h 36m
American Airlines
Deal found 3/23![American Airlines logo]()
$117
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:30 am
PWM
- MIA
2 stops12h 00m
Southwest
Deal found 3/23![Southwest logo]()
$133
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:00 am
PWM
- MIA
1 stop6h 29m
American Airlines
Deal found 3/20![American Airlines logo]()
$139
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/97:23 pm
PWM
- MIA
1 stop5h 36m
American Airlines
Deal found 3/21![American Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:01 pm
PWM
- MIA
2 stops23h 26m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$143
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/55:30 am
PWM
- MIA
2 stops10h 10m
Southwest
Deal found 3/20![Southwest logo]()
$144
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:15 am
PWM
- MIA
2 stops9h 49m
United Airlines
Deal found 3/19![United Airlines logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:19 pm
PWM
- MIA
2 stops30h 20m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$177
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/211:00 pm
PWM
- MIA
2 stops8h 55m
Southwest
Deal found 3/22![Southwest logo]()
$195
Find flight deals from Portland to Key Largo
Keep the following information in mind while searching for Portland to Key Largo flight deals. Data was last updated March 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $201 (American Airlines) |
One-way from | $93 (Southwest) |
Popular in | July |
Cheapest in | September |
Average price | $432 |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Portland to Key Largo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PortlandMiami
PWM - MIA
PWMMIA
Portland
Mon 4/13
2:50 pm-11:00 pm
1 stop8h 10m
Miami
Thu 4/16
6:25 pm-11:25 pm
1 stop5h 00m
$220
PortlandMiami
PWM - MIA
PWMMIA
Portland
Mon 6/1
5:30 am-3:20 pm
2 stops9h 50m
Miami
Thu 6/4
6:50 pm-12:05 am
1 stop5h 15m
$282
PortlandMiami
PWM - MIA
PWMMIA
Portland
Sat 5/2
9:20 am-4:16 pm
1 stop6h 56m
Miami
Wed 5/6
12:10 pm-9:19 pm
1 stop9h 09m
$308
PortlandMiami
PWM - MIA
PWMMIA
Portland
Fri 7/31
6:57 pm-12:55 am
1 stop5h 58m
Miami
Fri 8/7
8:01 am-4:01 pm
1 stop8h 00m
$338
Quickest round-trip
PortlandMiami
PWM - MIA
PWMMIA
Portland
Sat 5/9
9:20 am-4:16 pm
1 stop6h 56m
Miami
Wed 5/13
6:10 pm-11:59 pm
1 stop5h 49m
$367
PortlandMiami
PWM - MIA
PWMMIA
Portland
Wed 4/22
3:55 pm-9:10 pm
1 stop5h 15m
Miami
Wed 4/29
12:10 pm-10:35 pm
2 stops10h 25m
$403
PortlandMiami
PWM - MIA
PWMMIA
Portland
Fri 6/5
3:10 pm-11:15 pm
1 stop8h 05m
Miami
Sun 6/14
6:20 am-5:00 pm
1 stop10h 40m
$437
Cheapest one-way
PortlandMiami
PWM - MIA
PWMMIA
Portland
Mon 4/20
6:30 am-2:25 pm
1 stop7h 55m
$110
PortlandMiami
PWM - MIA
PWMMIA
Portland
Thu 4/30
2:50 pm-11:00 pm
1 stop8h 10m
$139
Quickest one-way
PortlandMiami
PWM - MIA
PWMMIA
Portland
Thu 4/9
7:23 pm-12:59 am
1 stop5h 36m
$139
Showing 1-10 of 18 resultsSorted by cheapest first
Best time to book a flight from Portland to Key Largo
Have a flexible travel schedule? Discover the best time to fly to Key Largo from Portland with our price prediction graph.
PWM-MIA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to Key Largo
PWM-KE9
PWM-MIA
How far ahead should I book a flight from Portland, Maine to Key Largo?
Use this chart to determine the optimal time to book a round-trip flight from Portland to Key Largo. Price data was last updated on March 13, 2026.
Booking 46 days in advance of your planned departure date is, on average, the best time to get cheap flights from Portland, Maine to Key Largo. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Portland, Maine to Key Largo?
Currently, January is the cheapest month in which you can book a flight from Portland, Maine to Key Largo (average of $60). Flying from Portland, Maine to Key Largo in December is currently the most expensive (average of $108). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Key Largo
Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated March 24, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Portland to Key Largo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Portland to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
Complete your trip to Key Largo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Portland to Key Largo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Portland and Key Largo flights
Browse other Portland and Key Largo flight options. Last updated on March 24, 2026.
Other flights from Portland
Browse through other flights departing from Portland. Flights are based on user searches made on Cheapflights and were last updated on March 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Portland to Key Largo flights
Consider these flights traveling from Portland to Key Largo.
Top 5 airlines flying from Portland to Key Largo
Discover the top 5 airlines that operate flights from Portland to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$336 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$200 | Average$314 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$215 | Average$398 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$216 | Average$436 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$216 | Average$372 | FlexibilityNo cancel fee | On-time69% |