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Italy

$345+ Cheap flights from Knoxville (TYS) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — NAP
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Find flight deals from Knoxville to Italy

Cheapest flights from Knoxville to Italy
Explore the most affordable flight options available from Knoxville to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This United deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/249:50 amTYS - FCO
2 stops19h 05mMultiple Airlines
Sun 12/71:10 pmFCO - TYS
2 stops36h 19mMultiple Airlines
Deal found 10/27$547
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:38 amTYS - FCO
2 stops22h 47mBritish Airways
Fri 12/1911:00 amFCO - TYS
1 stop15h 43mBritish Airways
Deal found 10/29$579
This Lufthansa deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:25 pmTYS - AOI
2 stops15h 05mLufthansa
Sun 12/79:45 amAOI - TYS
2 stops39h 44mLufthansa
Deal found 10/26$601
This Finnair deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:38 amTYS - FCO
1 stop19h 22mMultiple Airlines
Fri 12/1911:00 amFCO - TYS
1 stop15h 43mMultiple Airlines
Deal found 10/27$618
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/178:26 amTYS - FCO
1 stop17h 19mUnited Airlines
Mon 11/241:30 pmFCO - TYS
2 stops36h 50mUnited Airlines
Deal found 10/27$621
This KLM deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1711:25 amTYS - FCO
1 stop14h 30mKLM
Mon 11/2412:40 pmFCO - TYS
1 stop17h 01mKLM
Deal found 10/27$648
This KLM deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/122:41 pmTYS - CTA
2 stops17h 59mKLM
Sun 11/164:15 pmCTA - TYS
2 stops36h 54mKLM
Deal found 10/28$664
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/128:26 amTYS - FCO
1 stop17h 19mUnited Airlines
Fri 11/211:15 pmFCO - TYS
2 stops30h 02mUnited Airlines
Deal found 10/29$671
This Cheapflightsfares deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/41:52 pmTYS - BLQ
2 stops27h 08mLufthansa
Fri 11/146:40 amBLQ - TYS
2 stops22h 15mLufthansa
Deal found 10/27$679
This Cheapflightsfares deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:52 pmTYS - VCE
2 stops16h 23mLufthansa
Wed 11/196:55 amVCE - TYS
2 stops23h 04mLufthansa
Deal found 10/29$680
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/49:50 amTYS - BLQ
2 stops25h 10mUnited Airlines
Fri 11/1410:20 amBLQ - TYS
2 stops19h 24mUnited Airlines
Deal found 10/26$692
This Expedia deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:29 pmTYS - MXP
2 stops15h 51mBritish Airways
Thu 12/1811:30 amMXP - TYS
2 stops16h 28mBritish Airways
Deal found 10/27$734

Cheap flight deals from Knoxville to Italy

Keep the following information in mind while searching for Knoxville to Italy flight deals. Data was last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$547
(United)

One-way from

$345
(American Airlines)

Popular in

May

Cheapest in

November

Average price

$933
Provider with most accurate pricing for Knoxville McGhee Tyson-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Rome (ROM) flights.
Search Deals
From Knoxville McGhee Tyson to Italy
Search Deals
One-way flight from Knoxville McGhee Tyson to Italy
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($253 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($44 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Knoxville to Italy that are best for you.

Fly from

Knoxville

Fly to

Italy

Route

Depart

Return

Price

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Mon 11/24

9:50 am-10:55 am

2 stops19h 05m

Rome Fiumicino

Sun 12/7

1:10 pm-7:29 pm

2 stops36h 19m

$547

KnoxvilleVenice

TYS - VCE

TYSVCE

Knoxville McGhee Tyson

Thu 1/15

1:00 pm-11:45 am

2 stops16h 45m

Venice Marco Polo

Mon 1/19

6:30 am-8:47 pm

2 stops20h 17m

$550

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Thu 4/2

12:00 pm-9:25 am

1 stop15h 25m

Milan Malpensa

Thu 4/9

11:40 am-11:44 pm

1 stop18h 04m

$556

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Tue 1/13

11:10 am-6:15 pm

2 stops25h 05m

Rome Fiumicino

Fri 1/30

7:05 am-9:02 pm

2 stops19h 57m

$559

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Tue 1/13

6:10 pm-4:25 pm

2 stops16h 15m

Rome Fiumicino

Fri 1/30

12:40 pm-9:24 pm

1 stop14h 44m

$565

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Thu 4/2

12:00 pm-9:25 am

1 stop15h 25m

Milan Malpensa

Thu 4/9

11:25 am-11:44 pm

2 stops18h 19m

$566

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Fri 12/12

7:38 am-9:00 am

1 stop19h 22m

Rome Fiumicino

Fri 12/19

11:00 am-8:43 pm

1 stop15h 43m

$583

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Wed 2/25

6:35 am-9:00 am

1 stop20h 25m

Rome Fiumicino

Mon 3/9

6:40 pm-11:41 pm

2 stops34h 01m

$592

KnoxvilleAncona

TYS - AOI

TYSAOI

Knoxville McGhee Tyson

Wed 12/3

7:25 pm-4:30 pm

2 stops15h 05m

Ancona Falconara

Sun 12/7

9:45 am-7:29 pm

2 stops39h 44m

$601

KnoxvilleVenice

TYS - VCE

TYSVCE

Knoxville McGhee Tyson

Sun 3/15

9:40 am-12:45 pm

2 stops22h 05m

Venice Marco Polo

Mon 3/23

3:15 pm-2:56 pm

2 stops52h 41m

$608

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 44 results
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Best time to book a flight from Knoxville to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Italy

What is the cheapest month to book a flight from Knoxville to Italy?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Italy (average of $587). Flying from Knoxville to Italy in June is currently the most expensive (average of $1,084). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IT?

Find hourly flight availability from Knoxville to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Italy at noon. If you’re flexible enough to do this you can expect to save up to 13% on your trip compared to booking a flight in the evening.

What is the cheapest day to fly from Knoxville to Italy?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Italy. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Italy flight should consider departing on Friday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated October 29, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Italy have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Lufthansa
6.8
Okay
7,538 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
British Airways
6.7
Okay
7,483 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Italy?

    For a flight from Knoxville to Italy, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Italy?

    There are many flights that can get you from Knoxville to Italy in 15h 25m. Fly via Delta, KLM, or United Airlines to get the fastest option. Airlines will cover a distance of 4624 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Knoxville to Italy one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $345. However, be on the lookout for offers from Delta and Lufthansa, as they are both options that can get you from Knoxville to Italy for a low price.

  • What are the most popular routes from Knoxville to Italy?

    The most popular flight routes from Knoxville to Italy are Knoxville McGhee Tyson - Rome Fiumicino, Knoxville McGhee Tyson - Bologna Guglielmo Marconi and Knoxville McGhee Tyson - Venice Marco Polo.

  • Can I find deals for flights from Knoxville to Italy that include hotel bookings?

    Yes. In addition to deals on Knoxville to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Italy.

  • Can I find deals for business class flights from Knoxville to Italy?

    Yes. Cheapflights offers flight deals from Knoxville to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Italy?

    Currently, November is the cheapest month in which you can book a flight from Knoxville to Italy (average of $587). Flying from Knoxville to Italy in June is currently the most expensive (average of $1,084). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Knoxville to Italy

Discover the top 5 airlines that operate flights from Knoxville to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$612Average$1,137FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$620Average$1,202FlexibilityNo cancel feeOn-time69%
LufthansaCheapest$649Average$1,056FlexibilityNo cancel feeOn-time76%
American AirlinesCheapest$679Average$1,210FlexibilityNo cancel feeOn-time71%
British AirwaysCheapest$765Average$874FlexibilityNo cancel feeOn-time70%

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