HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Italy

$357+ Cheap flights from Knoxville (TYS) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — NAP
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Italy with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Italy

Cheapest flights from Knoxville to Italy
Explore the most affordable flight options available from Knoxville to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/122:30 pmTYS - FCO
1 stop12h 00mLufthansa
Sun 12/149:40 amFCO - TYS
2 stops17h 24mLufthansa
Deal found 12/9$1,554
This FlightHub deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/122:58 pmTYS - FCO
2 stops37h 42mAer Lingus
Sun 12/148:15 pmFCO - TYS
2 stops31h 25mAer Lingus
Deal found 12/9$1,568
This Ovago deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:23 pmTYS - FCO
1 stop31h 07mLufthansa
Wed 12/313:05 pmFCO - TYS
2 stops37h 34mLufthansa
Deal found 12/10$1,660
This KLM deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:31 pmTYS - FCO
1 stop33h 24mMultiple Airlines
Wed 12/3110:05 amFCO - TYS
1 stop16h 27mMultiple Airlines
Deal found 12/10$1,779
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:23 pmTYS - FCO
2 stops35h 17mUnited Airlines
Wed 12/3110:30 amFCO - TYS
2 stops36h 30mUnited Airlines
Deal found 12/11$1,818
This Air Canada deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/129:40 amTYS - FCO
3 stops21h 05mMultiple Airlines
Sun 12/141:10 pmFCO - TYS
2 stops27h 03mMultiple Airlines
Deal found 12/9$1,868
This Justfly.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/157:25 pmTYS - CTA
2 stops34h 10mLufthansa
Wed 12/173:25 pmCTA - TYS
2 stops37h 14mLufthansa
Deal found 12/11$2,965

Find flight deals from Knoxville to Italy

Keep the following information in mind while searching for Knoxville to Italy flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$436
(Kiwi.com)

One-way from

$357
(Kiwi.com)

Popular in

May

Cheapest in

December

Average price

$705
Provider with most accurate pricing for Knoxville McGhee Tyson-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Rome (ROM) flights.
Search Deals
From Knoxville McGhee Tyson to Italy
Search Deals
One-way flight from Knoxville McGhee Tyson to Italy
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($269 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($49 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Knoxville to Italy that are best for you.

Fly from

Knoxville

Fly to

Italy

Route

Depart

Return

Price

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Tue 1/20

2:25 pm-8:30 am

1 stop12h 05m

Rome Fiumicino

Tue 1/27

7:05 am-7:27 pm

2 stops18h 22m

$436

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Wed 1/28

2:25 pm-12:35 pm

2 stops16h 10m

Milan Malpensa

Sun 2/8

6:55 am-7:27 pm

2 stops18h 32m

$478

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Wed 1/28

5:00 pm-9:05 am

1 stop34h 05m

Milan Malpensa

Sun 2/8

12:00 pm-11:45 pm

2 stops17h 45m

$481

KnoxvilleMilan

TYS - LIN

TYSLIN

Knoxville McGhee Tyson

Wed 1/28

2:25 pm-10:05 am

2 stops13h 40m

Milan Linate

Sun 2/8

6:15 am-8:52 pm

2 stops20h 37m

$493

KnoxvilleMilan

TYS - LIN

TYSLIN

Knoxville McGhee Tyson

Wed 3/11

6:10 am-11:30 am

2 stops24h 20m

Milan Linate

Sat 3/21

6:50 pm-9:05 pm

2 stops31h 15m

$494

KnoxvilleBologna

TYS - BLQ

TYSBLQ

Knoxville McGhee Tyson

Fri 1/23

2:25 pm-12:40 pm

2 stops16h 15m

Bologna Guglielmo Marconi

Tue 1/27

6:00 am-10:57 am

2 stops34h 57m

$497

KnoxvilleFlorence

TYS - FLR

TYSFLR

Knoxville McGhee Tyson

Fri 1/23

9:30 am-2:05 pm

2 stops22h 35m

Florence Peretola

Tue 1/27

6:30 am-10:57 am

2 stops34h 27m

$501

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Tue 1/20

2:25 pm-11:05 am

2 stops38h 40m

Rome Fiumicino

Tue 1/27

7:05 am-7:27 pm

2 stops18h 22m

$502

KnoxvilleVenice

TYS - VCE

TYSVCE

Knoxville McGhee Tyson

Fri 1/23

2:25 pm-11:15 am

2 stops14h 50m

Venice Marco Polo

Tue 1/27

6:45 am-7:27 pm

2 stops18h 42m

$503

KnoxvilleMilan

TYS - LIN

TYSLIN

Knoxville McGhee Tyson

Fri 1/23

1:59 pm-11:55 am

2 stops15h 56m

Milan Linate

Tue 1/27

6:15 am-8:52 pm

2 stops20h 37m

$505

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Showing 1-10 of 42 results
1
2
3
...
5

Best time to book a flight from Knoxville to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Italy

What is the cheapest month to book a flight from Knoxville to Italy?

Currently, December is the cheapest month in which you can book a flight from Knoxville to Italy (average of $501). Flying from Knoxville to Italy in June is currently the most expensive (average of $1,097). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IT?

Find hourly flight availability from Knoxville to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Italy in the afternoon. If you’re flexible enough to do this you can expect to save up to 16% on your trip compared to booking a flight in the evening.

What is the cheapest day to fly from Knoxville to Italy?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Italy. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Italy flight should consider departing on Friday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated December 12, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Italy have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,009 reviews

Food

7.3

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,009 reviews
Delta
7.9
Good
8,009 reviews

Food

7.3

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,009 reviews

Food

7.3

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,048 reviews
Delta
7.9
Good
8,009 reviews

Food

7.3

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Lufthansa
6.8
Okay
7,626 reviews
Delta
7.9
Good
8,009 reviews

Food

7.3

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
British Airways
6.7
Okay
7,571 reviews
Delta
7.9
Good
8,009 reviews

Food

7.3

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Italy?

    For a flight from Knoxville to Italy, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Italy?

    There are many flights that can get you from Knoxville to Italy in 12h 05m. Fly via Lufthansa, KLM, or British Airways to get the fastest option. Airlines will cover a distance of 4908 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Italy?

    The most popular flight routes from Knoxville to Italy are Knoxville McGhee Tyson - Rome Fiumicino, Knoxville McGhee Tyson - Milan Malpensa and Knoxville McGhee Tyson - Milan Linate.

  • Can I find deals for flights from Knoxville to Italy that include hotel bookings?

    Yes. In addition to deals on Knoxville to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Italy.

  • Can I find deals for business class flights from Knoxville to Italy?

    Yes. Cheapflights offers flight deals from Knoxville to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Italy?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to Italy (average of $501). Flying from Knoxville to Italy in June is currently the most expensive (average of $1,097). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Italy

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Heathrow flights
Nashville to Dublin flights
Nashville to Gatwick flights
Nashville to Leonardo da Vinci/Fiumicino flights
Nashville to Charles de Gaulle flights
Nashville to Orly flights
Nashville to London City flights
Nashville to Stansted flights
Nashville to Amsterdam flights
Nashville to Barcelona-El Prat flights
Nashville to Athens flights
Nashville to Keflavik Intl flights
Nashville to Madrid flights
Memphis to Heathrow flights
Nashville to Florence flights
Nashville to Malpensa flights
Nashville to Zurich flights
Knoxville to Heathrow flights
Nashville to Frankfurt flights
Nashville to Linate flights
Nashville to Edinburgh flights
Nashville to Istanbul flights
Memphis to Charles de Gaulle flights
Knoxville to Charles de Gaulle flights
Knoxville to Frankfurt flights
Nashville to Bologna flights
Memphis to Dublin flights
Memphis to Orly flights
Knoxville to Dublin flights
Nashville to Lisbon flights
Nashville to Arlanda flights
Nashville to Bruxelles-National flights
Memphis to Leonardo da Vinci/Fiumicino flights
Nashville to Sabiha Gokcen flights
Knoxville to Leonardo da Vinci/Fiumicino flights
Nashville to Munich flights
Memphis to Gatwick flights
Nashville to Oslo Gardermoen flights
Memphis to Athens flights
Knoxville to London City flights
Knoxville to Barcelona-El Prat flights
Memphis to London City flights
Nashville to Manchester flights
Nashville to Vicenza flights
Nashville to Budapest flights
Nashville to Frederic Chopin flights
Nashville to Prague flights
Knoxville to Gatwick flights
Nashville to Glasgow Intl flights
Memphis to Madrid flights

Top 5 airlines flying from Knoxville to Italy

Discover the top 5 airlines that operate flights from Knoxville to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$500Average$994FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$583Average$1,213FlexibilityNo cancel feeOn-time71%
DeltaCheapest$612Average$1,078FlexibilityNo cancel feeOn-timeN/A
LufthansaCheapest$649Average$1,056FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$765Average$874FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.