HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Italy

$299+ Cheap flights from Knoxville (TYS) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — NAP
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Italy with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Italy

Keep the following information in mind while searching for Knoxville to Italy flight deals. Data was last updated September 11, 2025.

Round-trip from

$552
(FlightHub)

One-way from

$299
(Kiwi.com)

Popular in

May

Cheapest in

November

Average price

$1,117
From Knoxville McGhee Tyson to Italy
Search Deals
One-way flight from Knoxville McGhee Tyson to Italy
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($261 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($47 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Knoxville to Italy

Cheapest flights from Knoxville to Italy
Explore the most affordable flight options available from Knoxville to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This FlightHub deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/129:50 amTYS - FCO
2 stops17h 05mAir Canada
Fri 11/211:15 pmFCO - TYS
2 stops40h 44mAir Canada
Deal found 9/10$552
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/225:44 amTYS - FCO
1 stop19h 51mDelta
Thu 11/610:05 amFCO - TYS
1 stop17h 08mDelta
Deal found 9/8$575
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/222:16 pmTYS - FCO
1 stop16h 49mUnited Airlines
Thu 11/67:05 amFCO - TYS
2 stops19h 15mUnited Airlines
Deal found 9/8$578
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/266:12 amTYS - FCO
2 stops21h 33mDelta
Fri 11/712:00 pmFCO - TYS
2 stops29h 04mDelta
Deal found 9/8$579
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/278:26 amTYS - FCO
2 stops18h 29mUnited Airlines
Wed 11/57:05 amFCO - TYS
2 stops22h 54mUnited Airlines
Deal found 9/10$583
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/222:16 pmTYS - FCO
1 stop11h 59mUnited Airlines
Wed 11/57:00 amFCO - TYS
2 stops19h 33mUnited Airlines
Deal found 9/8$589
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/277:15 amTYS - FCO
1 stop25h 25mMultiple Airlines
Fri 11/77:00 pmFCO - TYS
2 stops49h 05mMultiple Airlines
Deal found 9/11$590
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/277:15 amTYS - FCO
1 stop25h 25mMultiple Airlines
Sat 11/87:25 amFCO - TYS
2 stops36h 40mMultiple Airlines
Deal found 9/11$598
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/272:25 pmTYS - FCO
2 stops18h 35mUnited Airlines
Tue 11/119:45 amFCO - TYS
2 stops20h 14mUnited Airlines
Deal found 9/11$599
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/265:52 pmTYS - FCO
2 stops19h 23mUnited Airlines
Wed 11/57:05 amFCO - TYS
2 stops19h 28mUnited Airlines
Deal found 9/10$601
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/279:50 amTYS - FCO
2 stops20h 10mUnited Airlines
Fri 11/79:45 amFCO - TYS
1 stop33h 32mUnited Airlines
Deal found 9/8$603
This KLM deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/122:50 pmTYS - CTA
2 stops23h 55mKLM
Sun 11/163:25 pmCTA - TYS
2 stops34h 41mKLM
Deal found 9/8$636

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Knoxville to Italy that are best for you.

Fly from

Knoxville

Fly to

Italy

Route

Depart

Return

Price

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Sun 3/1

7:00 am-7:45 am

1 stop18h 45m

Rome Fiumicino

Tue 3/31

11:30 am-1:18 pm

2 stops31h 48m

$552

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Sun 10/26

11:40 am-6:55 am

1 stop14h 15m

Rome Fiumicino

Thu 11/6

10:05 am-9:13 pm

1 stop17h 08m

$575

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Sun 3/1

7:58 am-9:00 am

1 stop19h 02m

Rome Fiumicino

Tue 3/31

1:10 pm-12:04 am

1 stop16h 54m

$575

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Wed 11/12

8:30 am-10:30 am

1 stop20h 00m

Rome Fiumicino

Fri 11/21

10:05 am-7:00 pm

1 stop14h 55m

$575

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Wed 10/22

8:50 am-9:15 am

2 stops18h 25m

Rome Fiumicino

Thu 11/6

9:45 am-8:33 pm

1 stop16h 48m

$575

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Wed 10/22

11:35 am-9:20 am

2 stops15h 45m

Rome Fiumicino

Fri 11/7

12:00 pm-11:04 am

2 stops29h 04m

$579

KnoxvilleRome

TYS - FCO

TYSFCO

Knoxville McGhee Tyson

Sun 10/26

11:40 am-6:55 am

1 stop14h 15m

Rome Fiumicino

Fri 11/7

12:00 pm-11:04 am

2 stops29h 04m

$579

KnoxvilleCatania

TYS - CTA

TYSCTA

Knoxville McGhee Tyson

Wed 11/12

2:50 pm-8:45 pm

2 stops23h 55m

Catania Fontanarossa

Sun 11/16

3:25 pm-8:06 pm

2 stops34h 41m

$636

KnoxvilleFlorence

TYS - FLR

TYSFLR

Knoxville McGhee Tyson

Sun 3/1

9:15 am-4:30 pm

2 stops25h 15m

Florence Peretola

Sun 3/8

6:30 am-10:53 pm

2 stops22h 23m

$641

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Wed 10/1

7:26 pm-6:05 pm

2 stops16h 39m

Milan Malpensa

Wed 10/15

3:20 pm-10:50 pm

1 stop13h 30m

$676

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 39 results
1
2
3
4

Best time to book a flight from Knoxville to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Italy

What is the cheapest month to book a flight from Knoxville to Italy?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Italy (average of $703). Flying from Knoxville to Italy in June is currently the most expensive (average of $1,202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IT?

Find hourly flight availability from Knoxville to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Knoxville to Italy, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated September 11, 2025.
See what other customers who have flown with Delta, KLM, and United Airlines from Knoxville to Italy have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
KLM
7.8
Good
1,385 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
British Airways
6.7
Okay
7,361 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Italy?

    For a flight from Knoxville to Italy, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Italy?

    There are many flights that can get you from Knoxville to Italy in 14h 15m. Fly via United Airlines, KLM, or Delta to get the fastest option. Airlines will cover a distance of 4908 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Italy?

    The most popular flight routes from Knoxville to Italy are Knoxville McGhee Tyson - Rome Fiumicino, Knoxville McGhee Tyson - Venice Marco Polo and Knoxville McGhee Tyson - Florence Peretola.

  • Can I find deals for flights from Knoxville to Italy that include hotel bookings?

    Yes. In addition to deals on Knoxville to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Italy.

  • Can I find deals for business class flights from Knoxville to Italy?

    Yes. Cheapflights offers flight deals from Knoxville to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Italy?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Italy (average of $703). Flying from Knoxville to Italy in June is currently the most expensive (average of $1,202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Italy

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Heathrow flights
Nashville to Gatwick flights
Nashville to Dublin flights
Nashville to Leonardo da Vinci/Fiumicino flights
Nashville to Charles de Gaulle flights
Nashville to Orly flights
Nashville to London City flights
Nashville to Keflavik Intl flights
Nashville to Barcelona-El Prat flights
Nashville to Lisbon flights
Nashville to Malpensa flights
Nashville to Madrid flights
Nashville to Frankfurt flights
Knoxville to Heathrow flights
Nashville to Athens flights
Nashville to Istanbul flights
Memphis to Heathrow flights
Nashville to Stansted flights
Nashville to Copenhagen flights
Nashville to Amsterdam flights
Knoxville to Frankfurt flights
Nashville to Linate flights
Knoxville to Charles de Gaulle flights
Nashville to Sabiha Gokcen flights
Nashville to Naples flights
Nashville to Munich flights
Nashville to Budapest flights
Knoxville to Dublin flights
Nashville to Zurich flights
Memphis to Charles de Gaulle flights
Memphis to Leonardo da Vinci/Fiumicino flights
Knoxville to Leonardo da Vinci/Fiumicino flights
Nashville to Edinburgh flights
Memphis to Malpensa flights
Knoxville to Edinburgh flights
Knoxville to London City flights
Nashville to Frederic Chopin flights
Nashville to Bruxelles-National flights
Nashville to Manchester flights
Memphis to London City flights
Memphis to Athens flights
Nashville to Glasgow Intl flights
Nashville to Vienna flights
Memphis to Gatwick flights
Knoxville to Vicenza flights
Blountville to Heathrow flights
Nashville to Arlanda flights
Memphis to Dublin flights
Memphis to Frankfurt flights
Knoxville to Frederic Chopin flights

Top 5 airlines flying from Knoxville to Italy

Discover the top 5 airlines that operate flights from Knoxville to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$649Average$1,096FlexibilityNo cancel feeOn-time76%
American AirlinesCheapest$679Average$1,262FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$702Average$1,202FlexibilityNo cancel feeOn-time69%
DeltaCheapest$717Average$1,166FlexibilityNo cancel feeOn-timeN/A
British AirwaysCheapest$765Average$957FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.