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$373+ Cheap flights from Knoxville (TYS) to Istanbul

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IST
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Knoxville to Istanbul

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Istanbul (TR5). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$1,087
(Orbitz)

One-way from

$373
(Mytrip)

Popular in

October

Cheapest in

February

Average price

$956
From Knoxville McGhee Tyson to Istanbul
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One-way flight from Knoxville McGhee Tyson to Istanbul
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Highest demand for flights based on searches. 10% potential increase in price ($150 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($108 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Istanbul

Cheapest flights from Knoxville to Istanbul
Explore the most affordable flight options available from Knoxville to Istanbul. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:08 pmTYS - IST
2 stops26h 17mDelta
Sun 10/125:05 pmIST - TYS
2 stops30h 26mDelta
Deal found 9/16$1,159
This oojo deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/210:57 amTYS - SAW
2 stops48h 48mQatar Airways
Sun 10/121:35 pmSAW - TYS
2 stops41h 16mQatar Airways
Deal found 9/16$1,709
This Ovago deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/24:49 pmTYS - IST
2 stops20h 41mRoyal Jordanian
Sat 10/112:00 amIST - TYS
2 stops26h 03mRoyal Jordanian
Deal found 9/16$1,886
This Air Canada deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/22:16 pmTYS - IST
3 stops19h 54mAir Canada
Sun 10/128:30 pmIST - TYS
3 stops31h 41mAir Canada
Deal found 9/16$3,550
This oojo deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/164:49 pmTYS - IST
2 stops20h 41mRoyal Jordanian
Tue 9/239:40 pmIST - TYS
2 stops30h 20mRoyal Jordanian
Deal found 9/15$3,806
This oojo deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/166:10 amTYS - SAW
2 stops47h 00mQatar Airways
Tue 9/238:05 pmSAW - TYS
2 stops32h 09mQatar Airways
Deal found 9/15$9,236
This oojo deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:15 amTYS - SAW
2 stops46h 55mQatar Airways
Thu 10/98:05 pmSAW - TYS
2 stops34h 34mQatar Airways
Deal found 9/15$9,557
This oojo deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:15 amTYS - IST
2 stops46h 40mQatar Airways
Thu 10/98:05 pmIST - TYS
2 stops34h 34mQatar Airways
Deal found 9/15$9,562

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Istanbul that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to Istanbul that are best for you.

Fly from

Knoxville

Fly to

Istanbul

Route

Depart

Return

Price

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Thu 10/2

6:08 pm-3:25 am

2 stops26h 17m

Istanbul

Sun 10/12

5:05 pm-4:31 pm

2 stops30h 26m

$1,159

KnoxvilleIstanbul

TYS - SAW

TYSSAW

Knoxville McGhee Tyson

Thu 10/2

10:57 am-6:45 pm

2 stops48h 48m

Istanbul Sabiha Gokcen

Sun 10/12

1:35 pm-11:51 pm

2 stops41h 16m

$1,709

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Thu 10/2

4:49 pm-8:30 pm

2 stops20h 41m

Istanbul

Sat 10/11

2:00 am-9:03 pm

2 stops26h 03m

$1,886

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Thu 10/2

2:16 pm-5:10 pm

3 stops19h 54m

Istanbul

Sun 10/12

8:30 pm-9:11 pm

3 stops31h 41m

$3,550

KnoxvilleIstanbul

TYS - SAW

TYSSAW

Knoxville McGhee Tyson

Tue 10/7

6:15 am-12:10 pm

2 stops46h 55m

Istanbul Sabiha Gokcen

Thu 10/9

8:05 pm-11:39 pm

2 stops34h 34m

$9,557

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Tue 10/7

6:15 am-11:55 am

2 stops46h 40m

Istanbul

Thu 10/9

8:05 pm-11:39 pm

2 stops34h 34m

$9,562

KnoxvilleIstanbul

TYS - SAW

TYSSAW

Knoxville McGhee Tyson

Wed 10/15

7:15 am-9:35 pm

3 stops31h 20m

$373

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Wed 10/15

7:15 am-3:50 am

3 stops37h 35m

$439

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Best time to book a flight from Knoxville to Istanbul

Have a flexible travel schedule? Discover the best time to fly to Istanbul from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Istanbul

What is the cheapest month to book a flight from Knoxville to Istanbul?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Istanbul (average of $910). Flying from Knoxville to Istanbul in June is currently the most expensive (average of $1,358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IST?

Find hourly flight availability from Knoxville to Istanbul. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 16% on flights from Knoxville to Istanbul by exploring options for tickets at noon.

How much does it cost to fly round-trip from Knoxville to Istanbul?

Reviews of airlines servicing Istanbul

Get insights into the airlines that provide service to Istanbul. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Istanbul. Reviews last updated September 17, 2025.
Read reviews from past customers who have flown Delta, Air France, and United Airlines from Knoxville to Istanbul. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Air France
7.4
Good
1,468 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
British Airways
6.7
Okay
7,367 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Istanbul. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Istanbul?

    If you book a flight to Istanbul from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from McGhee Tyson to Istanbul per day from 6 different airlines.

  • How long is the flight from Knoxville to Istanbul?

    Delta, Qatar Airways, and Royal Jordanian can get you from Knoxville to Istanbul in just under 20h 41m. Your travel time can differ by up to 28h 07m. Airlines will cover a distance of 5617 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Istanbul round-trip?

    Our cheapest airline available from Knoxville to Istanbul is Lufthansa. Our recent data shows that you can find tickets from as low as $648 on this airline. Additional options worth looking into are British Airways and American Airlines, starting at $765 and $770 round-trip. These flights start at 47% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to Istanbul that include hotel bookings?

    Yes. In addition to deals on Knoxville to Istanbul flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Istanbul?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Istanbul.

  • Can I find deals for business class flights from Knoxville to Istanbul?

    Yes. Cheapflights offers flight deals from Knoxville to Istanbul by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Istanbul?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Istanbul (average of $910). Flying from Knoxville to Istanbul in June is currently the most expensive (average of $1,358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 6 airlines flying from Knoxville to Istanbul

Discover the top 6 airlines that operate flights from Knoxville to Istanbul. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$648Average$1,231FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$765Average$1,071FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$770Average$1,321FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$930Average$1,180FlexibilityNo cancel feeOn-time69%
DeltaCheapest$954Average$1,185FlexibilityNo cancel feeOn-timeN/A
Air FranceCheapest$2,396Average$2,396FlexibilityNo cancel feeOn-time77%

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