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$576+ Cheap flights from Knoxville (TYS) to Istanbul

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IST
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Cheap flight deals from Knoxville to Istanbul

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Istanbul (TR5). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octubre 30, 2025.

Round-trip from

$576
(British Airways)

Popular in

December

Cheapest in

February

Average price

$945
From Knoxville McGhee Tyson to Istanbul
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Highest demand for flights based on searches. 0% potential increase in price ($2 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($39 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Knoxville to Istanbul

Cheapest flights from Knoxville to Istanbul
Explore the most affordable flight options available from Knoxville to Istanbul. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/187:30 amTYS - SAW
3 stops29h 55mMultiple Airlines
jue. 11/208:30 amSAW - TYS
3 stops21h 33mMultiple Airlines
Deal found 10/30$951
This Priceline deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/123:40 pmTYS - IST
2 stops17h 45mBritish Airways
vie. 12/198:10 amIST - TYS
2 stops21h 48mBritish Airways
Deal found 10/27$1,019
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/142:30 pmTYS - IST
2 stops18h 15mUnited Airlines
dom. 12/2110:35 amIST - TYS
2 stops41h 16mUnited Airlines
Deal found 10/29$1,169
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/146:00 amTYS - IST
3 stops28h 25mMultiple Airlines
dom. 12/217:45 amIST - TYS
2 stops22h 11mMultiple Airlines
Deal found 10/29$1,254
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/127:15 amTYS - IST
3 stops27h 10mMultiple Airlines
vie. 12/192:00 pmIST - TYS
2 stops32h 55mMultiple Airlines
Deal found 10/27$1,283
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/147:59 pmTYS - IST
2 stops23h 51mDelta
sáb. 12/204:50 amIST - TYS
2 stops22h 37mDelta
Deal found 10/29$1,404
This KLM deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/193:53 pmTYS - SAW
2 stops21h 27mKLM
dom. 11/233:45 pmSAW - TYS
2 stops39h 56mKLM
Deal found 10/29$1,536
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/23:59 pmTYS - IST
2 stops27h 51mDelta
dom. 11/95:55 pmIST - TYS
2 stops34h 05mDelta
Deal found 10/28$1,548
This KLM deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/182:41 pmTYS - SAW
2 stops18h 44mKLM
jue. 11/209:00 amSAW - TYS
2 stops20h 50mKLM
Deal found 10/30$3,734

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Istanbul that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Knoxville to Istanbul that are best for you.

Fly from

Knoxville

Fly to

Istanbul

Route

Depart

Return

Price

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

jue. 1/8

7:44 am-1:10 am

2 stops33h 26m

Istanbul

vie. 1/23

8:10 am-10:09 pm

2 stops21h 59m

$576

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

jue. 1/8

6:19 am-4:55 pm

2 stops26h 36m

Istanbul

jue. 1/22

4:50 am-8:47 pm

2 stops23h 57m

$688

KnoxvilleIstanbul

TYS - SAW

TYSSAW

Knoxville McGhee Tyson

mar. 11/18

7:30 am-9:25 pm

3 stops29h 55m

Istanbul Sabiha Gokcen

jue. 11/20

8:30 am-10:03 pm

3 stops21h 33m

$951

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

vie. 12/12

3:40 pm-5:25 pm

2 stops17h 45m

Istanbul

vie. 12/19

8:10 am-9:58 pm

2 stops21h 48m

$1,019

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

dom. 12/14

2:30 pm-4:45 pm

2 stops18h 15m

Istanbul

dom. 12/21

10:35 am-7:51 pm

2 stops41h 16m

$1,169

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

dom. 12/14

6:00 am-6:25 pm

3 stops28h 25m

Istanbul

sáb. 12/20

2:20 am-9:56 pm

2 stops27h 36m

$1,254

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

vie. 12/12

7:15 am-6:25 pm

3 stops27h 10m

Istanbul

vie. 12/19

2:00 pm-2:55 pm

2 stops32h 55m

$1,283

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

dom. 12/14

7:59 pm-3:50 am

2 stops23h 51m

Istanbul

sáb. 12/20

4:50 am-7:27 pm

2 stops22h 37m

$1,404

KnoxvilleIstanbul

TYS - SAW

TYSSAW

Knoxville McGhee Tyson

mié. 11/19

3:53 pm-9:20 pm

2 stops21h 27m

Istanbul Sabiha Gokcen

dom. 11/23

3:45 pm-11:41 pm

2 stops39h 56m

$1,536

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

dom. 11/2

3:59 pm-3:50 am

2 stops27h 51m

Istanbul

dom. 11/9

5:55 pm-8:00 pm

2 stops34h 05m

$1,548

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 12 results
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Best time to book a flight from Knoxville to Istanbul

Have a flexible travel schedule? Discover the best time to fly to Istanbul from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Istanbul

What is the cheapest month to book a flight from Knoxville to Istanbul?

Currently, February is the cheapest month in which you can book a flight from Knoxville to Istanbul (average of $554). Flying from Knoxville to Istanbul in June is currently the most expensive (average of $1,362). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IST?

Find hourly flight availability from Knoxville to Istanbul. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 15% on flights from Knoxville to Istanbul by exploring options for tickets at noon.

Reviews of airlines servicing Istanbul

Get insights into the airlines that provide service to Istanbul. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Istanbul. Reviews last updated octubre 30, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Istanbul. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,993 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,030 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Lufthansa
6.8
Okay
7,541 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
British Airways
6.7
Okay
7,487 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Istanbul. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Istanbul?

    If you book a flight to Istanbul from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from McGhee Tyson to Istanbul per day from 5 different airlines.

  • How long is the flight from Knoxville to Istanbul?

    British Airways, Delta, and United Airlines can get you from Knoxville to Istanbul in just under 18h 15m. Your travel time can differ by up to 15h 11m. Airlines will cover a distance of 5617 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Istanbul round-trip?

    Our cheapest airline available from Knoxville to Istanbul is Lufthansa. Our recent data shows that you can find tickets from as low as $648 on this airline. Additional options worth looking into are British Airways and American Airlines, starting at $758 and $770 round-trip. These flights start at 41% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to Istanbul that include hotel bookings?

    Yes. In addition to deals on Knoxville to Istanbul flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Istanbul?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Istanbul.

  • Can I find deals for business class flights from Knoxville to Istanbul?

    Yes. Cheapflights offers flight deals from Knoxville to Istanbul by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Istanbul?

    Currently, February is the cheapest month in which you can book a flight from Knoxville to Istanbul (average of $554). Flying from Knoxville to Istanbul in June is currently the most expensive (average of $1,362). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Knoxville to Istanbul

Discover the top 5 airlines that operate flights from Knoxville to Istanbul. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$648Average$1,231FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$758Average$1,071FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$770Average$1,173FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$930Average$1,180FlexibilityNo cancel feeOn-time69%
DeltaCheapest$954Average$1,185FlexibilityNo cancel feeOn-timeN/A

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