HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Istanbul

$650+ Cheap flights from Knoxville (TYS) to Istanbul

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IST
dic. 17 — dic. 241
mié. 12/17
mié. 12/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Istanbul with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Istanbul

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Istanbul (TR5). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated noviembre 17, 2025.

Round-trip from

$650
(United Airlines)

Popular in

June

Cheapest in

February

Average price

$770
From Knoxville McGhee Tyson to Istanbul
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($310 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($39 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Find flight deals from Knoxville to Istanbul

Cheapest flights from Knoxville to Istanbul
Explore the most affordable flight options available from Knoxville to Istanbul. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 17, 2025.

This Lufthansa deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/47:25 pmTYS - IST
2 stops14h 40mLufthansa
lun. 12/86:30 amIST - TYS
2 stops22h 34mLufthansa
Deal found 11/16$775
This Delta deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/47:59 pmTYS - IST
2 stops23h 51mDelta
dom. 12/74:50 amIST - TYS
2 stops25h 00mDelta
Deal found 11/16$787
This KLM deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/412:50 pmTYS - SAW
2 stops20h 35mKLM
lun. 12/89:00 amSAW - TYS
2 stops22h 28mKLM
Deal found 11/16$934
This Trip.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/287:15 amTYS - IST
2 stops26h 10mMultiple Airlines
jue. 12/117:35 amIST - TYS
2 stops36h 20mMultiple Airlines
Deal found 11/17$945
This United Airlines deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/302:00 pmTYS - IST
2 stops19h 45mUnited Airlines
mar. 1/610:35 amIST - TYS
2 stops42h 17mUnited Airlines
Deal found 11/14$998
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/283:53 pmTYS - IST
2 stops27h 57mDelta
mié. 12/104:50 amIST - TYS
2 stops26h 38mDelta
Deal found 11/17$1,022
This Ovago deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/161:52 pmTYS - IST
2 stops19h 53mLufthansa
mar. 12/236:30 amIST - TYS
2 stops25h 29mLufthansa
Deal found 11/16$1,188
This Mytrip deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/168:06 amTYS - IST
3 stops26h 19mMultiple Airlines
mar. 12/232:15 pmIST - TYS
3 stops34h 00mMultiple Airlines
Deal found 11/16$1,637
This oojo deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/165:03 pmTYS - SAW
2 stops35h 07mQatar Airways
mar. 12/231:40 pmSAW - TYS
2 stops33h 59mQatar Airways
Deal found 11/16$3,163
This oojo deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/225:15 amTYS - SAW
2 stops46h 55mQatar Airways
lun. 1/51:40 pmSAW - TYS
2 stops35h 26mQatar Airways
Deal found 11/16$5,139

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Istanbul that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 17, 2025.
Use the filters below to find and compare flights from Knoxville to Istanbul that are best for you.

Fly from

Knoxville

Fly to

Istanbul

Route

Depart

Return

Price

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

lun. 4/13

9:40 am-12:55 pm

2 stops20h 15m

Istanbul

mié. 5/6

1:50 pm-9:59 am

2 stops51h 09m

$650

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

mié. 4/15

9:15 am-9:15 pm

2 stops29h 00m

Istanbul

mié. 5/6

1:50 pm-1:18 pm

2 stops54h 28m

$652

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

jue. 12/4

7:25 pm-6:05 pm

2 stops14h 40m

Istanbul

lun. 12/8

6:30 am-9:04 pm

2 stops22h 34m

$775

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

jue. 12/4

7:59 pm-3:50 am

2 stops23h 51m

Istanbul

dom. 12/7

4:50 am-9:50 pm

2 stops25h 00m

$787

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

vie. 3/27

4:00 pm-4:30 am

2 stops29h 30m

Istanbul

mar. 3/31

4:30 am-11:44 pm

2 stops26h 14m

$858

KnoxvilleIstanbul

TYS - SAW

TYSSAW

Knoxville McGhee Tyson

jue. 12/4

12:50 pm-5:25 pm

2 stops20h 35m

Istanbul Sabiha Gokcen

lun. 12/8

9:00 am-11:28 pm

2 stops22h 28m

$934

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

vie. 11/28

7:15 am-5:25 pm

2 stops26h 10m

Istanbul

jue. 12/11

7:35 am-11:55 am

2 stops36h 20m

$945

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

lun. 5/11

7:55 am-3:50 pm

2 stops24h 55m

Istanbul

lun. 5/25

8:15 pm-9:12 pm

2 stops31h 57m

$985

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

mar. 12/30

2:00 pm-5:45 pm

2 stops19h 45m

Istanbul

mar. 1/6

10:35 am-8:52 pm

2 stops42h 17m

$998

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

vie. 11/28

3:53 pm-3:50 am

2 stops27h 57m

Istanbul

mié. 12/10

4:50 am-11:28 pm

2 stops26h 38m

$1,022

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/15

Showing 1-10 of 15 results
1
2

Best time to book a flight from Knoxville to Istanbul

Have a flexible travel schedule? Discover the best time to fly to Istanbul from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Istanbul

What is the cheapest month to book a flight from Knoxville to Istanbul?

Currently, February is the cheapest month in which you can book a flight from Knoxville to Istanbul (average of $554). Flying from Knoxville to Istanbul in June is currently the most expensive (average of $1,362). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IST?

Find hourly flight availability from Knoxville to Istanbul. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 17, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 15% on flights from Knoxville to Istanbul by exploring options for tickets at noon.

Reviews of airlines servicing Istanbul

Get insights into the airlines that provide service to Istanbul. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Istanbul. Reviews last updated noviembre 17, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Istanbul. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,006 reviews

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,006 reviews
Delta
7.9
Good
8,006 reviews

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,014 reviews
Delta
7.9
Good
8,006 reviews

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,046 reviews
Delta
7.9
Good
8,006 reviews

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Lufthansa
6.8
Okay
7,576 reviews
Delta
7.9
Good
8,006 reviews

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
British Airways
6.7
Okay
7,528 reviews
Delta
7.9
Good
8,006 reviews

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Istanbul. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Istanbul?

    If you book a flight to Istanbul from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from McGhee Tyson to Istanbul per day from 5 different airlines.

  • How long is the flight from Knoxville to Istanbul?

    United Airlines, Lufthansa, and Delta can get you from Knoxville to Istanbul in just under 14h 40m. Your travel time can differ by up to 9h 11m. Airlines will cover a distance of 5617 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Istanbul round-trip?

    Our cheapest airline available from Knoxville to Istanbul is Lufthansa. Our recent data shows that you can find tickets from as low as $648 on this airline. Additional options worth looking into are British Airways and American Airlines, starting at $758 and $770 round-trip. These flights start at 38% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to Istanbul that include hotel bookings?

    Yes. In addition to deals on Knoxville to Istanbul flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Istanbul?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Istanbul.

  • Can I find deals for business class flights from Knoxville to Istanbul?

    Yes. Cheapflights offers flight deals from Knoxville to Istanbul by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Istanbul?

    Currently, February is the cheapest month in which you can book a flight from Knoxville to Istanbul (average of $554). Flying from Knoxville to Istanbul in June is currently the most expensive (average of $1,362). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 5 airlines flying from Knoxville to Istanbul

Discover the top 5 airlines that operate flights from Knoxville to Istanbul. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$648Average$1,231FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$758Average$1,071FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$770Average$1,173FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$930Average$1,180FlexibilityNo cancel feeOn-time69%
DeltaCheapest$954Average$1,185FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.