It’s generally more expensive to depart on a Sunday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.
Flights from Key West to Honolulu lean towards being more expensive in December. Prices are generally better when you fly from Key West to Honolulu in March, with the cheapest ticket starting at $229.
A simple way to save on the total cost of your ticket is to fly from Key West to Honolulu at noon. If you’re flexible enough to do this you can expect to save up to 48% on your trip compared to booking a flight in the morning.