How long is the flight from Panama City, Florida to Guayaquil?

Airlines like United Airlines and American Airlines fly from Panama City, Florida to Guayaquil in about 10h 49m. The time it takes to get you to your destination can typically vary by up to 10h 12m. Airlines will cover a distance of 2279 mi. Both multi-stop and nonstop flights can be found to your destination and back.

In terms of precipitation, rainfall in Guayaquil ranges from 0.0 - 11.0 inches per month. March is typically the wettest month, when rainfall can reach 11.0 in. July is typically the driest time to visit Guayaquil when rainfall is around 0.0 in.

If weather is an important factor for your trip to Guayaquil, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 77.0 F).

What is the cheapest time of day to fly from ECP to GYE?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to Guayaquil as you normally would.

Most accurate provider : When it comes to deals on Panama City, Florida-Guayaquil flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Guayaquil flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Guayaquil flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City, Florida-Guayaquil flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?

Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Guayaquil?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.

Can I find deals for business class flights from Panama City to Guayaquil?

Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$632+ Flights from Panama City, FL to Guayaquil

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Panama City to Guayaquil with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Guayaquil

Best flights from Panama City to Guayaquil
Discover carefully curated flight deals from Panama City to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.

Wed 5/136:40 amECP - GYE

2 stops10h 49mUnited Airlines

Sun 5/178:28 amGYE - ECP

2 stops37h 28mUnited Airlines

Deal found 12/24

$632

Sun 2/154:30 pmECP - GYE

2 stops21h 01mAmerican Airlines

Fri 2/203:31 pmGYE - ECP

2 stops21h 36mAmerican Airlines

Deal found 12/25

$680

Thu 1/296:30 amECP - GYE

2 stops16h 12mUnited Airlines

Mon 2/28:34 amGYE - ECP

2 stops32h 39mUnited Airlines

Deal found 12/25

$649

Wed 1/76:30 amECP - GYE

2 stops16h 12mUnited Airlines

Thu 1/228:34 amGYE - ECP

2 stops28h 28mUnited Airlines

Deal found 12/26

$909

Last-minute flights from Panama City to Guayaquil
Discover last-minute flight deals from Panama City to Guayaquil. Data last updated December 27, 2025 and is based on user searches.

Wed 1/76:30 amECP - GYE

2 stops16h 12mUnited Airlines

Thu 1/228:34 amGYE - ECP

2 stops28h 28mUnited Airlines

Deal found 12/26

$909

Thu 1/296:30 amECP - GYE

2 stops16h 12mUnited Airlines

Mon 2/28:34 amGYE - ECP

2 stops32h 39mUnited Airlines

Deal found 12/25

$649

Find flight deals from Panama City to Guayaquil

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$632 (United Airlines)

Provider with most accurate pricing for Panama City NW Florida Beaches-Guayaquil Jose Joaquin de Olmedo flight deals.

Search Deals

Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Guayaquil Jose Joaquin de Olmedo flights.

Search Deals

From Panama City NW Florida Beaches to Guayaquil Jose Joaquin de Olmedo

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Wed 5/13

6:40 am-5:29 pm

2 stops10h 49m

Guayaquil Jose Joaquin de Olmedo

Sun 5/17

8:28 am-9:56 pm

2 stops37h 28m

$632

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Thu 1/29

6:30 am-11:42 pm

2 stops16h 12m

Guayaquil Jose Joaquin de Olmedo

Mon 2/2

8:34 am-4:13 pm

2 stops32h 39m

$649

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sun 2/15

4:30 pm-2:31 pm

2 stops21h 01m

Guayaquil Jose Joaquin de Olmedo

Fri 2/20

3:31 pm-12:07 pm

2 stops21h 36m

$680

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Wed 1/7

6:30 am-11:42 pm

2 stops16h 12m

Guayaquil Jose Joaquin de Olmedo

Thu 1/22

8:34 am-12:02 pm

2 stops28h 28m

$909

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/24

Compare providers for flights from Panama City to Guayaquil

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Guayaquil in December.

Provider	Price Accuracy	Trust Score*
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City, Florida-Guayaquil flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Guayaquil flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Guayaquil flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City, Florida-Guayaquil flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

How long is the flight from Panama City, Florida to Guayaquil?
Airlines like United Airlines and American Airlines fly from Panama City, Florida to Guayaquil in about 10h 49m. The time it takes to get you to your destination can typically vary by up to 10h 12m. Airlines will cover a distance of 2279 mi. Both multi-stop and nonstop flights can be found to your destination and back.
Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?
Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Guayaquil?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.
Can I find deals for business class flights from Panama City to Guayaquil?
Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Panama City to Guayaquil

Miami to Quito flights

Miami to Guayaquil flights

Fort Lauderdale to Guayaquil flights

Fort Lauderdale to Quito flights

Tampa to Quito flights

Orlando to Guayaquil flights

Orlando to Quito flights

Miami to Baltra flights

Tampa to Guayaquil flights

Jacksonville to Quito flights

Miami to San Cristobal flights

West Palm Beach to Quito flights

Jacksonville to Guayaquil flights

West Palm Beach to Guayaquil flights

Orlando to Manta flights

Gainesville to Quito flights

Miami to Cuenca flights

Fort Myers to Quito flights

Tallahassee to Quito flights

Fort Lauderdale to Baltra flights

Pensacola to Guayaquil flights

Tampa to Cuenca flights

Fort Lauderdale to Cuenca flights

Sarasota to Quito flights

Miami to Puerto Francisco de Orellana flights

Orlando to San Cristobal flights

Orlando to Baltra flights

Tampa to San Cristobal flights

Fort Lauderdale to San Cristobal flights

Tallahassee to Guayaquil flights

Valparaiso to Quito flights

Daytona Beach to Quito flights

Tampa to Baltra flights

Orlando to Cuenca flights

Melbourne to Quito flights

Orlando to Loja flights

Other flights to Guayaquil

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$632+ Cheap flights from Panama City, FL (ECP) to Guayaquil (GYE)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/13. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Guayaquil with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to Guayaquil

Best flights from Panama City to GuayaquilDiscover carefully curated flight deals from Panama City to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.

Discover carefully curated flight deals from Panama City to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.

Find flight deals from Panama City to Guayaquil

Most accurate provider

Most trusted provider

Round-trip from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.

Compare providers for flights from Panama City to Guayaquil

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Guayaquil in December.

Best time to book a flight from Panama City to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Panama City, Florida to Guayaquil?

Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?

How can I find direct flights from Panama City to Guayaquil?

Can I find deals for business class flights from Panama City to Guayaquil?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.

100% Free

Book with Flexibility

Travel Smart

Best flights from Panama City to Guayaquil
Discover carefully curated flight deals from Panama City to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.