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Guayaquil

$375+ Cheap flights from Panama City, FL (ECP) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GYE
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from Panama City to Guayaquil

Cheapest flights from Panama City to Guayaquil
Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:30 am
ECP
-
GYE
2 stops17h 11m
United Airlines
Tue 3/178:32 am
GYE
-
ECP
2 stops31h 40m
United Airlines
Deal found 2/8$587
This KAYAK deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/111:35 am
ECP
-
GYE
2 stops33h 18m
Multiple Airlines
Fri 7/316:50 pm
GYE
-
ECP
2 stops16h 15m
Multiple Airlines
Deal found 2/8$648
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/281:01 pm
ECP
-
GYE
2 stops30h 45m
United Airlines
Wed 3/42:35 pm
GYE
-
ECP
2 stops32h 22m
United Airlines
Deal found 2/7$815
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:30 am
ECP
-
GYE
2 stops13h 16m
United Airlines
Fri 2/2712:20 pm
GYE
-
ECP
2 stops24h 44m
United Airlines
Deal found 2/11$977

Find flight deals from Panama City to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$587
(United Airlines)

One-way from

$375
(United Airlines)
Provider with most accurate pricing for Panama City NW Florida Beaches-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From Panama City NW Florida Beaches to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from Panama City NW Florida Beaches to Guayaquil Jose Joaquin de Olmedo
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.

Fly from

Panama City

Fly to

Guayaquil

Route

Depart

Return

Price

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Tue 3/10

6:30 am-11:41 pm

2 stops17h 11m

Guayaquil Jose Joaquin de Olmedo

Tue 3/17

8:32 am-4:12 pm

2 stops31h 40m

$587

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Wed 7/1

11:35 am-8:53 pm

2 stops33h 18m

Guayaquil Jose Joaquin de Olmedo

Fri 7/31

6:50 pm-11:05 am

2 stops16h 15m

$648

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sat 2/28

1:01 pm-8:46 pm

2 stops30h 45m

Guayaquil Jose Joaquin de Olmedo

Wed 3/4

2:35 pm-9:57 pm

2 stops32h 22m

$815

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Tue 2/24

6:30 am-8:46 pm

2 stops13h 16m

Guayaquil Jose Joaquin de Olmedo

Fri 2/27

12:20 pm-12:04 pm

2 stops24h 44m

$977

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sat 5/2

6:30 am-11:36 pm

2 stops17h 06m

$375

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Fri 5/8

6:30 am-8:52 pm

2 stops14h 22m

$380

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sat 2/28

6:30 am-8:46 pm

2 stops13h 16m

$460

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Wed 2/18

6:30 am-11:42 pm

2 stops16h 12m

$507

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sat 5/2

5:49 am-5:35 pm

3 stops35h 46m

$731

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/8

Compare providers for flights from Panama City to Guayaquil

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Guayaquil in February.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Guayaquil flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Guayaquil flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Guayaquil flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Guayaquil flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Guayaquil?

    Airlines like United Airlines fly from Panama City, Florida to Guayaquil in about 17h 11m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 2279 mi.

  • Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.

  • Can I find deals for business class flights from Panama City to Guayaquil?

    Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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