$529+ Cheap flights from Panama City, FL (ECP) to Guayaquil (GYE)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/28. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GYE
Dec 13 — Dec 201
1 adult, Economy
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1. Tell us where you want to go
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Cheapest flights from Panama City to GuayaquilExplore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.
Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.
This United deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:30 amECP - GYE
2 stops16h 11mMultiple Airlines
Tue 11/189:05 amGYE - ECP
2 stops31h 58mMultiple Airlines
Deal found 11/11![Multiple Airlines logo]()
$1,009
Cheap flight deals from Panama City to Guayaquil
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $682 (United Airlines) |
One-way from | $529 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.
Fly from
Panama City
Fly to
Guayaquil
Route
Depart
Return
Price
Panama CityGuayaquil
ECP - GYE
ECPGYE
Panama City NW Florida Beaches
Sun 4/5
4:55 pm-8:46 pm
2 stops27h 51m
Guayaquil Jose Joaquin de Olmedo
Wed 4/8
12:20 pm-9:52 am
2 stops21h 32m
$682
Panama CityGuayaquil
ECP - GYE
ECPGYE
Panama City NW Florida Beaches
Sun 12/28
4:45 pm-11:41 pm
2 stops29h 56m
$529
Compare providers for flights from Panama City to Guayaquil
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Guayaquil in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Guayaquil flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Guayaquil flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Guayaquil flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Guayaquil flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Guayaquil
Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.