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Greenville

$185+ Cheap flights from Portland, ME to Greenville (PWM - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — GSP
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Portland to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$240
(Delta)

One-way from

$185
(United Airlines)

Popular in

June

Cheapest in

September

Average price

$258
From Portland to Greenville
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One-way flight from Portland to Greenville
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Highest demand for flights based on searches. 9% potential increase in price ($40 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Portland to Greenville

Cheapest flights from Portland to Greenville
Explore the most affordable flight options available from Portland to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/304:55 pmPWM - GSP
1 stop5h 46mDelta
Thu 10/27:45 pmGSP - PWM
1 stop4h 26mDelta
Deal found 9/9$240
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:14 amPWM - GSP
1 stop5h 32mUnited Airlines
Mon 10/69:35 amGSP - PWM
1 stop8h 07mUnited Airlines
Deal found 9/10$243
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/95:43 amPWM - GSP
1 stop4h 20mAmerican Airlines
Tue 11/117:38 pmGSP - PWM
1 stop4h 21mAmerican Airlines
Deal found 9/10$259
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/23:56 pmPWM - GSP
1 stop5h 04mAmerican Airlines
Sun 10/57:44 pmGSP - PWM
1 stop4h 01mAmerican Airlines
Deal found 9/10$298
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/295:45 amPWM - GSP
1 stop4h 15mSouthwest
Mon 11/34:45 pmGSP - PWM
1 stop5h 30mSouthwest
Deal found 9/8$303
This Breeze Airways deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/233:15 pmPWM - GSP
1 stop4h 08mBreeze Airways
Sun 10/2610:33 amGSP - PWM
1 stop3h 57mBreeze Airways
Deal found 9/11$305
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:00 amPWM - GSP
1 stop7h 10mDelta
Tue 11/111:58 pmGSP - PWM
2 stops9h 56mDelta
Deal found 9/10$313
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/21:35 pmPWM - GSP
1 stop6h 50mDelta
Sun 10/55:30 amGSP - PWM
2 stops8h 30mDelta
Deal found 9/10$316
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/297:44 amPWM - GSP
2 stops7h 05mAmerican Airlines
Mon 11/37:38 pmGSP - PWM
1 stop4h 21mAmerican Airlines
Deal found 9/8$327
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:21 pmPWM - GSP
1 stop16h 42mAmerican Airlines
Wed 11/127:38 amGSP - PWM
1 stop4h 08mAmerican Airlines
Deal found 9/10$343

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Portland to Greenville that are best for you.

Fly from

Portland

Fly to

Greenville

Route

Depart

Return

Price

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Tue 9/30

4:55 pm-10:41 pm

1 stop5h 46m

Greenville

Thu 10/2

7:45 pm-12:11 am

1 stop4h 26m

$240

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Thu 10/2

6:14 am-11:46 am

1 stop5h 32m

Greenville

Mon 10/6

9:35 am-5:42 pm

1 stop8h 07m

$243

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Thu 10/2

3:56 pm-9:00 pm

1 stop5h 04m

Greenville

Sun 10/5

7:44 pm-11:45 pm

1 stop4h 01m

$298

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 10/29

5:45 am-10:00 am

1 stop4h 15m

Greenville

Mon 11/3

4:45 pm-10:15 pm

1 stop5h 30m

$303

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Thu 10/23

3:15 pm-7:23 pm

1 stop4h 08m

Greenville

Sun 10/26

10:33 am-2:30 pm

1 stop3h 57m

$305

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Sun 11/9

6:00 am-1:10 pm

1 stop7h 10m

Greenville

Tue 11/11

1:58 pm-11:54 pm

2 stops9h 56m

$313

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Thu 10/2

1:35 pm-8:25 pm

1 stop6h 50m

Greenville

Sun 10/5

5:30 am-2:00 pm

2 stops8h 30m

$316

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Sun 11/9

5:43 am-2:06 pm

2 stops8h 23m

Greenville

Tue 11/11

7:38 pm-11:59 pm

1 stop4h 21m

$318

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Fri 11/7

5:21 pm-10:03 am

1 stop16h 42m

Greenville

Wed 11/12

7:38 am-11:46 am

1 stop4h 08m

$343

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 9/24

3:21 pm-10:28 am

1 stop19h 07m

Greenville

Mon 9/29

7:26 pm-10:41 am

2 stops39h 15m

$354

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 12 results
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Best time to book a flight from Portland to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Greenville

What is the cheapest month to book a flight from Portland, Maine to Greenville?

Currently, August is the cheapest month in which you can book a flight from Portland, Maine to Greenville (average of $322). Flying from Portland, Maine to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Portland to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,960 reviews
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,937 reviews
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Portland to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Portland, Maine to Greenville?

    There are many flights that can get you from Portland, Maine to Greenville in 5h 04m. Fly via Delta, United Airlines, or American Airlines to get the fastest option. The distance between Portland, Maine and Greenville is about 876 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Portland, Maine to Greenville round-trip?

    Currently priced at $258, American Airlines will fly you from Portland, Maine to Greenville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $270 and $296, respectively. American Airlines is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Portland to Greenville that include hotel bookings?

    Yes. In addition to deals on Portland to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Greenville.

  • Can I find deals for business class flights from Portland to Greenville?

    Yes. Cheapflights offers flight deals from Portland to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Greenville?

    Currently, August is the cheapest month in which you can book a flight from Portland, Maine to Greenville (average of $322). Flying from Portland, Maine to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 4 airlines flying from Portland to Greenville

Discover the top 4 airlines that operate flights from Portland to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$394FlexibilityNo cancel feeOn-time71%
DeltaCheapest$270Average$364FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$296Average$340FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$301Average$416FlexibilityNo cancel feeOn-time63%

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