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Greenville

$297+ Cheap flights from Portland, ME to Greenville (PWM - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — GSP
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Portland to Greenville

Cheapest flights from Portland to Greenville
Explore the most affordable flight options available from Portland to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/412:43 pm
PWM
-
GSP
1 stop4h 31m
Delta
Mon 3/95:41 pm
GSP
-
PWM
1 stop5h 41m
Delta
Deal found 1/27$297
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:00 am
PWM
-
GSP
1 stop4h 20m
American Airlines
Mon 3/307:37 pm
GSP
-
PWM
1 stop4h 18m
American Airlines
Deal found 1/26$325
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/65:31 am
PWM
-
GSP
1 stop5h 42m
Delta
Mon 3/95:41 pm
GSP
-
PWM
1 stop5h 41m
Delta
Deal found 1/27$352
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:07 pm
PWM
-
GSP
1 stop17h 18m
American Airlines
Fri 2/277:37 pm
GSP
-
PWM
1 stop4h 13m
American Airlines
Deal found 1/25$354
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/95:20 am
PWM
-
GSP
1 stop5h 10m
American Airlines
Wed 2/117:42 pm
GSP
-
PWM
1 stop4h 01m
American Airlines
Deal found 1/26$359
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:50 pm
PWM
-
GSP
1 stop7h 00m
Southwest
Mon 3/912:25 pm
GSP
-
PWM
2 stops11h 40m
Southwest
Deal found 1/27$365
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:00 am
PWM
-
GSP
1 stop4h 19m
American Airlines
Mon 3/97:37 pm
GSP
-
PWM
1 stop4h 18m
American Airlines
Deal found 1/25$367
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
PWM
-
GSP
1 stop4h 26m
Delta
Sun 7/126:00 am
GSP
-
PWM
1 stop7h 21m
Delta
Deal found 1/26$387
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2011:50 am
PWM
-
GSP
2 stops7h 15m
Southwest
Fri 2/278:30 am
GSP
-
PWM
1 stop5h 15m
Southwest
Deal found 1/25$388

Find flight deals from Portland to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$325
(American Airlines)

Popular in

November

Cheapest in

September

Average price

$584
Provider with most accurate pricing for Portland-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Greenville flights.
Search Deals
From Portland to Greenville
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($61 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Portland to Greenville that are best for you.

Fly from

Portland

Fly to

Greenville

Route

Depart

Return

Price

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 3/4

12:43 pm-5:14 pm

1 stop4h 31m

Greenville

Mon 3/9

5:41 pm-11:22 pm

1 stop5h 41m

$297

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Fri 3/27

6:00 am-10:20 am

1 stop4h 20m

Greenville

Mon 3/30

7:37 pm-11:55 pm

1 stop4h 18m

$325

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Fri 2/20

5:07 pm-10:25 am

1 stop17h 18m

Greenville

Fri 2/27

7:37 pm-11:50 pm

1 stop4h 13m

$354

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Mon 2/9

5:20 am-10:30 am

1 stop5h 10m

Greenville

Wed 2/11

5:40 pm-10:07 pm

1 stop4h 27m

$359

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Thu 3/5

2:50 pm-9:50 pm

1 stop7h 00m

Greenville

Mon 3/9

12:25 pm-12:05 am

2 stops11h 40m

$365

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Fri 3/6

5:31 am-11:13 am

1 stop5h 42m

Greenville

Mon 3/9

5:40 am-12:09 pm

2 stops6h 29m

$379

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Fri 2/20

11:50 am-7:05 pm

2 stops7h 15m

Greenville

Fri 2/27

8:30 am-1:45 pm

1 stop5h 15m

$388

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 3/4

5:45 am-5:40 pm

2 stops11h 55m

Greenville

Mon 3/9

12:25 pm-12:05 am

2 stops11h 40m

$403

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Fri 3/6

5:07 pm-10:05 pm

1 stop4h 58m

Greenville

Mon 3/9

7:37 pm-11:55 pm

1 stop4h 18m

$407

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Sat 4/18

1:20 pm-10:46 pm

2 stops9h 26m

$335

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Compare providers for flights from Portland to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Greenville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Portland, Maine-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland, Maine-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland, Maine-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Portland, Maine-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland, Maine-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Portland to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Greenville

What is the cheapest month to book a flight from Portland, Maine to Greenville?

Currently, May is the cheapest month in which you can book a flight from Portland, Maine to Greenville (average of $54). Flying from Portland, Maine to Greenville in January is currently the most expensive (average of $140). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Portland, Maine to Greenville?

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated January 27, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Portland to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,118 reviews

Food

7.2

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,118 reviews
Delta
7.9
Good
8,118 reviews

Food

7.2

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,197 reviews
Delta
7.9
Good
8,118 reviews

Food

7.2

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Portland to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Portland, Maine to Greenville?

    There are many flights that can get you from Portland, Maine to Greenville in 4h 20m. Fly via Delta or American Airlines to get the fastest option. The distance between Portland, Maine and Greenville is about 876 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Portland, Maine to Greenville round-trip?

    Currently priced at $213, Delta will fly you from Portland, Maine to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $258. Delta is priced at 50% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Portland, Maine to Greenville one-way?

    $94 is the cheapest one-way deal found within the past few days, from Breeze Airways. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $118 and $148, respectively.

  • Can I find deals for flights from Portland to Greenville that include hotel bookings?

    Yes. In addition to deals on Portland to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Greenville.

  • Can I find deals for business class flights from Portland to Greenville?

    Yes. Cheapflights offers flight deals from Portland to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Greenville?

    Currently, May is the cheapest month in which you can book a flight from Portland, Maine to Greenville (average of $54). Flying from Portland, Maine to Greenville in January is currently the most expensive (average of $140). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top 2 airlines flying from Portland to Greenville

Discover the top 2 airlines that operate flights from Portland to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$213Average$380FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$366FlexibilityNo cancel feeOn-time71%

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