$320+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
Oct 5 — Oct 121
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to Durham
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Best
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Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:14 pm -
2 stops27h 43m
Thu 11/194:48 pm -
1 stop18h 19m
Deal found 9/3![Multiple Airlines logo]()
$320
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:05 am -
1 stop5h 13m
Sat 10/106:10 am -
1 stop7h 03m
Deal found 9/2![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:18 pm -
1 stop7h 49m
Wed 12/26:02 am -
1 stop6h 36m
Deal found 9/5![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:00 am -
1 stop7h 02m
Sun 11/158:15 pm -
1 stop5h 14m
Deal found 9/4![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:48 am -
1 stop4h 56m
Tue 12/13:03 pm -
2 stops9h 27m
Deal found 9/2![United Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:00 pm -
1 stop5h 48m
Tue 12/16:00 am -
1 stop5h 17m
Deal found 9/2![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:31 am -
1 stop4h 41m
Tue 12/16:00 am -
1 stop5h 17m
Deal found 9/5![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:31 am -
1 stop4h 41m
Thu 12/33:06 pm -
1 stop6h 03m
Deal found 9/5![Delta logo]()
$363
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:48 am -
1 stop4h 56m
Tue 12/16:25 am -
1 stop5h 07m
Deal found 9/2![United Airlines logo]()
$366
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:30 am -
1 stop6h 03m
Wed 9/306:56 pm -
1 stop4h 55m
Deal found 9/2![Delta logo]()
$369
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:30 am -
1 stop6h 03m
Wed 9/306:56 pm -
1 stop4h 55m
Deal found 9/1![Delta logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:52 pm -
2 stops26h 37m
Thu 10/84:48 pm -
1 stop17h 31m
Deal found 9/5![Multiple Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/232:18 pm -
1 stop7h 18m
Mon 12/287:06 pm -
1 stop6h 40m
Deal found 9/5![American Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:50 am -
1 stop7h 13m
Sat 10/34:27 pm -
1 stop8h 17m
Deal found 8/31![United Airlines logo]()
$411
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:27 pm -
2 stops7h 32m
Tue 12/15:00 am -
2 stops7h 41m
Deal found 9/2![American Airlines logo]()
$417
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/124:09 pm -
1 stop6h 44m
Mon 2/156:00 am -
1 stop7h 11m
Deal found 9/3![Delta logo]()
$439
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:00 am -
2 stops8h 54m
Wed 9/303:36 pm -
2 stops9h 53m
Deal found 9/3![American Airlines logo]()
$466
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated September 5, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated September 5, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:47 am -
1 stop7h 15m
Tue 9/224:23 pm -
1 stop8h 21m
Deal found 9/3![United Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:30 am -
1 stop6h 03m
Wed 9/306:56 pm -
1 stop4h 55m
Deal found 9/2![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:00 am -
1 stop6h 03m
Wed 9/3011:42 am -
1 stop9h 00m
Deal found 9/4![American Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:50 am -
1 stop7h 13m
Sat 10/34:27 pm -
1 stop8h 17m
Deal found 8/31![United Airlines logo]()
$411
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:52 pm -
2 stops26h 37m
Thu 10/84:48 pm -
1 stop17h 31m
Deal found 9/5![Multiple Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:05 am -
1 stop5h 13m
Sat 10/106:10 am -
1 stop7h 03m
Deal found 9/2![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:48 pm -
1 stop6h 00m
Sun 10/116:00 am -
1 stop6h 34m
Deal found 9/1![American Airlines logo]()
$397
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated September 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $320 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $338 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Sat 9/19
5:30 am-12:33 pm
1 stop6h 03m
Raleigh-Durham
Wed 9/30
6:56 pm-10:51 pm
1 stop4h 55m
$369
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 10/2
8:52 pm-12:29 am
2 stops26h 37m
Raleigh-Durham
Thu 10/8
4:48 pm-9:19 am
1 stop17h 31m
$384
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 12/23
2:18 pm-10:36 pm
1 stop7h 18m
Raleigh-Durham
Mon 12/28
7:06 pm-12:46 am
1 stop6h 40m
$409
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/30
7:50 am-4:03 pm
1 stop7h 13m
Raleigh-Durham
Sat 10/3
4:27 pm-11:44 pm
1 stop8h 17m
$411
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Mon 11/23
3:27 pm-11:59 pm
2 stops7h 32m
Raleigh-Durham
Tue 12/1
5:00 am-11:41 am
2 stops7h 41m
$417
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 2/12
4:09 pm-11:53 pm
1 stop6h 44m
Raleigh-Durham
Mon 2/15
6:00 am-12:11 pm
1 stop7h 11m
$439
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Sat 9/19
7:00 am-4:54 pm
2 stops8h 54m
Raleigh-Durham
Wed 9/30
3:36 pm-12:29 am
2 stops9h 53m
$466
Sorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
How much does it cost to fly round-trip from Sioux Falls to Durham?
Airfare is typical for this route at the moment.
Sioux Falls to Durham flights typically cost between $270 and $448 in November.The cheapest round-trip price found within the last 5 days was $320 on Multiple Airlines (Nov 15-Nov 19).
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated September 5, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Sioux Falls to Durham
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Complete your trip
Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Sioux Falls to Durham by cabin class
Find flights from Sioux Falls to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on September 5, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on September 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$340 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$299 | Average$412 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$511 | FlexibilityNo cancel fee | On-time69% |