$127+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
Sep 4 — Sep 111
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
This Expedia deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:08 pm -
1 stop14h 23m
Wed 8/1212:26 pm -
1 stop7h 57m
Deal found 8/3![Frontier logo]()
$292
This Expedia deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:08 pm -
1 stop14h 23m
Fri 8/1412:26 pm -
1 stop7h 57m
Deal found 8/3![Frontier logo]()
$310
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop9h 05m
Sat 9/126:00 am -
1 stop6h 36m
Deal found 7/31![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:03 am -
1 stop5h 15m
Sat 10/106:10 am -
1 stop7h 02m
Deal found 8/3![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/223:26 pm -
1 stop7h 27m
Tue 12/19:35 am -
1 stop6h 31m
Deal found 8/3![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/412:57 pm -
2 stops8h 56m
Mon 9/76:30 am -
1 stop6h 47m
Deal found 8/3![American Airlines logo]()
$334
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop9h 05m
Sat 9/126:00 am -
1 stop6h 36m
Deal found 8/1![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:03 am -
1 stop5h 15m
Sat 10/106:10 am -
1 stop7h 02m
Deal found 8/4![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:24 am -
1 stop5h 24m
Mon 9/73:36 pm -
2 stops9h 54m
Deal found 8/1![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:23 pm -
1 stop5h 19m
Mon 9/76:30 am -
1 stop6h 47m
Deal found 8/3![American Airlines logo]()
$399
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated August 5, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated August 5, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:08 pm -
1 stop14h 23m
Wed 8/1212:26 pm -
1 stop7h 57m
Deal found 8/3![Frontier logo]()
$292
This Expedia deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:08 pm -
1 stop14h 23m
Fri 8/1412:26 pm -
1 stop7h 57m
Deal found 8/3![Frontier logo]()
$310
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:28 pm -
1 stop6h 26m
Mon 9/76:00 am -
1 stop5h 20m
Deal found 8/1![Delta logo]()
$345
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:24 am -
1 stop5h 24m
Mon 9/73:36 pm -
2 stops9h 54m
Deal found 8/1![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/412:57 pm -
2 stops8h 56m
Mon 9/76:30 am -
1 stop6h 47m
Deal found 8/3![American Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop9h 05m
Sat 9/126:00 am -
1 stop6h 36m
Deal found 7/31![American Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:28 pm -
1 stop6h 27m
Fri 9/256:56 pm -
1 stop4h 55m
Deal found 8/3![Delta logo]()
$382
One-way flights from Sioux Falls to DurhamSearch for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
Search for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:22 pm -
1 stop12h 56m
Deal found 8/4![Multiple Airlines logo]()
$127
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/121:33 pm -
1 stop6h 46m
Deal found 8/4![United Airlines logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/511:29 am -
1 stop28h 30m
Deal found 8/4![Multiple Airlines logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:55 am -
2 stops22h 14m
Deal found 8/4![Multiple Airlines logo]()
$165
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1212:56 pm -
2 stops9h 01m
Deal found 8/4![American Airlines logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:55 am -
2 stops22h 14m
Deal found 8/4![Multiple Airlines logo]()
$168
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:30 am -
1 stop4h 56m
Deal found 8/4![Delta logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:52 pm -
2 stops38h 46m
Deal found 8/4![Frontier logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:52 pm -
2 stops38h 46m
Deal found 8/4![Frontier logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:48 pm -
3 stops44h 22m
Deal found 8/4![Multiple Airlines logo]()
$198
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated August 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $321 (American Airlines) |
One-way from | $127 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $332 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/9
6:00 am-4:05 pm
1 stop9h 05m
Raleigh-Durham
Sat 9/12
6:00 am-11:36 am
1 stop6h 36m
$321
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Tue 10/6
7:03 am-1:18 pm
1 stop5h 15m
Raleigh-Durham
Sat 10/10
6:10 am-12:12 pm
1 stop7h 02m
$325
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Mon 8/31
6:24 am-12:48 pm
1 stop5h 24m
Raleigh-Durham
Mon 9/7
3:36 pm-12:30 am
2 stops9h 54m
$354
Quickest round-trip
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 9/4
5:23 pm-11:42 pm
1 stop5h 19m
Raleigh-Durham
Mon 9/7
6:30 am-12:17 pm
1 stop6h 47m
$399
Cheapest one-way
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Mon 9/21
9:55 am-4:31 pm
2 stops29h 36m
$178
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Thu 9/10
5:30 am-11:26 am
1 stop4h 56m
$178
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 9/11
10:40 am-5:51 pm
1 stop6h 11m
$178
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Mon 9/21
7:40 am-4:02 pm
1 stop7h 22m
$309
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Sun 9/27
10:02 pm-5:22 pm
3 stops18h 20m
$314
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Sun 9/13
5:30 am-1:54 pm
1 stop7h 24m
$322
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated August 5, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Sioux Falls to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on August 5, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on August 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$398 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$511 | FlexibilityNo cancel fee | On-time69% |