$202+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
Aug 29 — Sep 51
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
FSD
- RDU
1 stop9h 05m
American Airlines
Sat 9/126:00 am
RDU
- FSD
1 stop6h 36m
American Airlines
Deal found 7/26![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:03 am
FSD
- RDU
1 stop5h 10m
American Airlines
Sat 10/106:10 am
RDU
- FSD
1 stop7h 03m
American Airlines
Deal found 7/26![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:23 pm
FSD
- RDU
1 stop5h 19m
American Airlines
Sun 8/306:30 am
RDU
- FSD
1 stop6h 47m
American Airlines
Deal found 7/28![American Airlines logo]()
$329
This Expedia deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/318:08 pm
FSD
- RDU
1 stop14h 23m
Frontier
Mon 8/312:26 pm
RDU
- FSD
1 stop7h 57m
Frontier
Deal found 7/26![Frontier logo]()
$340
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:28 pm
FSD
- RDU
1 stop6h 26m
Delta
Sun 8/306:00 am
RDU
- FSD
1 stop7h 38m
Delta
Deal found 7/28![Delta logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2410:28 am
FSD
- RDU
2 stops30h 47m
Multiple Airlines
Sun 8/307:54 pm
RDU
- FSD
1 stop25h 07m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$360
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/21:45 pm
FSD
- RDU
1 stop8h 20m
United Airlines
Sat 12/510:30 am
RDU
- FSD
1 stop5h 05m
United Airlines
Deal found 7/26![United Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
FSD
- RDU
1 stop9h 05m
American Airlines
Sat 9/126:00 am
RDU
- FSD
1 stop6h 36m
American Airlines
Deal found 7/25![American Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:30 am
FSD
- RDU
1 stop5h 16m
Delta
Sun 8/166:00 am
RDU
- FSD
1 stop7h 38m
Delta
Deal found 7/28![Delta logo]()
$395
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:03 am
FSD
- RDU
1 stop5h 10m
American Airlines
Sat 10/106:10 am
RDU
- FSD
1 stop7h 03m
American Airlines
Deal found 7/25![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:30 am
FSD
- RDU
1 stop4h 43m
Delta
Fri 10/166:00 am
RDU
- FSD
1 stop5h 00m
Delta
Deal found 7/28![Delta logo]()
$461
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1212:57 pm
FSD
- RDU
2 stops8h 56m
American Airlines
Sun 8/162:47 pm
RDU
- FSD
2 stops8h 20m
American Airlines
Deal found 7/28![American Airlines logo]()
$503
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:31 pm
FSD
- RDU
1 stop23h 17m
United Airlines
Fri 10/25:01 pm
RDU
- FSD
1 stop18h 28m
United Airlines
Deal found 7/29![United Airlines logo]()
$637
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated July 30, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated July 30, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/318:08 pm
FSD
- RDU
1 stop14h 23m
Frontier
Mon 8/312:26 pm
RDU
- FSD
1 stop7h 57m
Frontier
Deal found 7/26![Frontier logo]()
$340
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:23 pm
FSD
- RDU
1 stop5h 29m
American Airlines
Sat 8/152:07 pm
RDU
- FSD
1 stop7h 24m
American Airlines
Deal found 7/27![American Airlines logo]()
$406
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:30 am
FSD
- RDU
1 stop5h 16m
Delta
Sun 8/166:00 am
RDU
- FSD
1 stop7h 38m
Delta
Deal found 7/28![Delta logo]()
$395
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:24 am
FSD
- RDU
1 stop5h 24m
American Airlines
Sat 8/292:07 pm
RDU
- FSD
1 stop7h 24m
American Airlines
Deal found 7/28![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:23 pm
FSD
- RDU
1 stop5h 19m
American Airlines
Sun 8/306:30 am
RDU
- FSD
1 stop6h 47m
American Airlines
Deal found 7/28![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:28 pm
FSD
- RDU
1 stop6h 26m
Delta
Sun 8/306:00 am
RDU
- FSD
1 stop7h 38m
Delta
Deal found 7/28![Delta logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2410:28 am
FSD
- RDU
2 stops30h 47m
Multiple Airlines
Sun 8/307:54 pm
RDU
- FSD
1 stop25h 07m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:24 am
FSD
- RDU
2 stops9h 19m
American Airlines
Sat 8/297:04 am
RDU
- FSD
1 stop5h 32m
American Airlines
Deal found 7/28![American Airlines logo]()
$420
One-way flights from Sioux Falls to DurhamSearch for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
Search for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/3010:00 pm
FSD
- RDU
2 stops46h 08m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/261:50 pm
FSD
- RDU
2 stops45h 46m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:00 pm
FSD
- RDU
2 stops18h 07m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$265
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:24 am
FSD
- RDU
1 stop7h 53m
American Airlines
Deal found 7/29![American Airlines logo]()
$309
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated July 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $321 (American Airlines) |
One-way from | $202 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $412 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 12/2
1:45 pm-11:05 pm
1 stop8h 20m
Raleigh-Durham
Sat 12/5
10:30 am-2:35 pm
1 stop5h 05m
$321
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/9
6:00 am-4:05 pm
1 stop9h 05m
Raleigh-Durham
Sat 9/12
6:00 am-11:36 am
1 stop6h 36m
$321
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Tue 10/6
7:03 am-1:13 pm
1 stop5h 10m
Raleigh-Durham
Sat 10/10
6:10 am-12:13 pm
1 stop7h 03m
$325
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 8/12
5:30 am-11:46 am
1 stop5h 16m
Raleigh-Durham
Sun 8/16
6:00 am-12:38 pm
1 stop7h 38m
$395
Quickest round-trip
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Fri 10/9
8:30 am-2:13 pm
1 stop4h 43m
Raleigh-Durham
Fri 10/16
6:00 am-10:00 am
1 stop5h 00m
$461
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 8/12
12:57 pm-10:53 pm
2 stops8h 56m
Raleigh-Durham
Sun 8/16
2:47 pm-10:07 pm
2 stops8h 20m
$503
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Mon 9/28
6:31 pm-6:48 pm
1 stop23h 17m
Raleigh-Durham
Fri 10/2
5:01 pm-10:29 am
1 stop18h 28m
$637
Cheapest one-way
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sun 8/30
10:00 pm-9:08 pm
2 stops46h 08m
$202
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 8/26
1:50 pm-12:36 pm
2 stops45h 46m
$249
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Thu 8/27
10:00 pm-5:07 pm
2 stops18h 07m
$265
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated July 30, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Comfort
7.8
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Comfort
7.8
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Comfort
7.8
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on July 30, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on July 30, 2026.
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Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$364 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$473 | FlexibilityNo cancel fee | On-time69% |