$225+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
Sep 10 — Sep 171
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Sioux Falls to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to Durham
Cheapest
Best
Last-minute
One-way
Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
This Frontier deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:56 pm -
1 stop21h 13m
Sun 9/67:54 pm -
1 stop25h 07m
Deal found 8/10![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:12 pm -
2 stops19h 19m
Fri 10/912:18 pm -
1 stop7h 18m
Deal found 8/6![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:12 pm -
2 stops19h 19m
Sat 10/1012:18 pm -
1 stop7h 18m
Deal found 8/6![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:52 pm -
2 stops38h 46m
Fri 10/912:18 pm -
1 stop7h 18m
Deal found 8/6![Frontier logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:48 pm -
2 stops26h 29m
Mon 11/912:48 pm -
1 stop8h 05m
Deal found 8/7![Frontier logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:13 pm -
1 stop12h 46m
Mon 11/912:48 pm -
1 stop8h 05m
Deal found 8/7![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:52 pm -
2 stops38h 46m
Sat 10/1012:18 pm -
1 stop7h 18m
Deal found 8/6![Frontier logo]()
$313
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:03 am -
1 stop5h 15m
Sat 10/106:10 am -
1 stop7h 02m
Deal found 8/10![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop6h 27m
Sat 9/126:00 am -
1 stop7h 16m
Deal found 8/7![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:23 pm -
1 stop5h 29m
Fri 9/112:18 pm -
1 stop7h 27m
Deal found 8/8![American Airlines logo]()
$329
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop9h 05m
Sat 9/126:00 am -
1 stop6h 36m
Deal found 8/8![American Airlines logo]()
$321
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:48 am -
1 stop4h 56m
Mon 11/25:19 pm -
1 stop5h 18m
Deal found 8/6![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:30 am -
1 stop4h 51m
Tue 10/137:21 pm -
1 stop5h 01m
Deal found 8/6![Delta logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:46 am -
2 stops29h 23m
Mon 11/212:48 pm -
1 stop8h 05m
Deal found 8/6![Multiple Airlines logo]()
$356
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:03 am -
1 stop5h 15m
Sat 10/106:10 am -
1 stop7h 02m
Deal found 8/9![American Airlines logo]()
$321
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/17:40 am -
1 stop7h 45m
Mon 1/45:09 pm -
1 stop6h 26m
Deal found 8/10![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:05 am -
1 stop4h 31m
Wed 10/73:08 pm -
1 stop5h 24m
Deal found 8/6![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:00 am -
1 stop6h 03m
Sun 9/206:00 am -
1 stop7h 16m
Deal found 8/9![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:28 pm -
1 stop6h 27m
Sat 10/101:45 pm -
1 stop7h 10m
Deal found 8/7![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:23 am -
1 stop4h 45m
Wed 10/73:08 pm -
1 stop5h 24m
Deal found 8/6![Delta logo]()
$367
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated August 11, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated August 11, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:56 pm -
1 stop21h 13m
Sun 9/67:54 pm -
1 stop25h 07m
Deal found 8/10![Frontier logo]()
$225
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:28 pm -
1 stop6h 26m
Sun 9/63:35 pm -
1 stop5h 24m
Deal found 8/10![Delta logo]()
$343
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:23 pm -
1 stop5h 29m
Fri 9/112:18 pm -
1 stop7h 27m
Deal found 8/8![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop9h 05m
Sat 9/126:00 am -
1 stop6h 36m
Deal found 8/10![American Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:30 am -
1 stop4h 51m
Tue 10/137:21 pm -
1 stop5h 01m
Deal found 8/6![Delta logo]()
$335
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:23 am -
1 stop4h 45m
Fri 10/93:08 pm -
1 stop5h 24m
Deal found 8/6![Delta logo]()
$340
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:23 am -
1 stop4h 45m
Mon 10/127:21 pm -
1 stop5h 01m
Deal found 8/6![Delta logo]()
$367
One-way flights from Sioux Falls to DurhamSearch for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
Search for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/81:33 pm -
1 stop8h 53m
Deal found 8/10![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/812:06 pm -
2 stops9h 47m
Deal found 8/10![American Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:47 am -
1 stop5h 20m
Deal found 8/6![United Airlines logo]()
$350
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated August 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $225 (Frontier) |
Popular in | June |
Cheapest in | October |
Average price | $332 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/9
6:00 am-4:05 pm
1 stop9h 05m
Raleigh-Durham
Sat 9/12
6:00 am-11:36 am
1 stop6h 36m
$321
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Tue 10/6
7:03 am-1:18 pm
1 stop5h 15m
Raleigh-Durham
Sat 10/10
6:10 am-12:12 pm
1 stop7h 02m
$321
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Thu 10/29
7:48 am-1:44 pm
1 stop4h 56m
Raleigh-Durham
Mon 11/2
5:19 pm-9:37 pm
1 stop5h 18m
$329
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 1/1
7:40 am-4:25 pm
1 stop7h 45m
Raleigh-Durham
Mon 1/4
5:09 pm-10:35 pm
1 stop6h 26m
$329
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Thu 9/17
7:00 am-2:03 pm
1 stop6h 03m
Raleigh-Durham
Sun 9/20
6:00 am-12:16 pm
1 stop7h 16m
$329
Quickest round-trip
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Tue 9/29
5:30 am-11:21 am
1 stop4h 51m
Raleigh-Durham
Tue 10/13
7:21 pm-11:22 pm
1 stop5h 01m
$335
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/30
5:05 am-10:36 am
1 stop4h 31m
Raleigh-Durham
Wed 10/7
3:08 pm-7:32 pm
1 stop5h 24m
$335
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 10/2
4:28 pm-11:55 pm
1 stop6h 27m
Raleigh-Durham
Sat 10/10
1:45 pm-7:55 pm
1 stop7h 10m
$339
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Thu 10/29
11:46 am-6:09 pm
2 stops29h 23m
Raleigh-Durham
Mon 11/2
12:48 pm-7:53 pm
1 stop8h 05m
$356
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Thu 10/1
8:23 am-2:08 pm
1 stop4h 45m
Raleigh-Durham
Wed 10/7
3:08 pm-7:32 pm
1 stop5h 24m
$367
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated August 11, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Sioux Falls
Popular flights
Top destinations
Alternative routes for Sioux Falls to Durham
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Sioux Falls to Durham by cabin class
Find flights from Sioux Falls to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on August 11, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on August 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$271 | Average$409 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$511 | FlexibilityNo cancel fee | On-time69% |