$154+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/29. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
Jun 11 — Jun 181
Round-trip
1 adult, Economy
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Best
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Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 12, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 12, 2026.
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:19 am
FSD
- RDU
1 stop6h 32m
American Airlines
Sat 9/1211:52 am
RDU
- FSD
1 stop6h 30m
American Airlines
Deal found 5/12![American Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:25 am
FSD
- RDU
2 stops9h 08m
Delta
Sat 9/128:45 am
RDU
- FSD
2 stops11h 21m
Delta
Deal found 5/9![Delta logo]()
$321
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:25 am
FSD
- RDU
1 stop6h 24m
Delta
Sat 10/101:00 pm
RDU
- FSD
2 stops10h 12m
Delta
Deal found 5/8![Delta logo]()
$326
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:25 am
FSD
- RDU
1 stop6h 36m
Delta
Mon 9/143:30 pm
RDU
- FSD
1 stop7h 39m
Delta
Deal found 5/11![Delta logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:14 pm
FSD
- RDU
1 stop19h 05m
Multiple Airlines
Wed 6/175:30 pm
RDU
- FSD
1 stop25h 31m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$331
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
FSD
- RDU
1 stop6h 23m
American Airlines
Sat 6/66:11 pm
RDU
- FSD
1 stop6h 45m
American Airlines
Deal found 5/11![American Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:51 pm
FSD
- RDU
1 stop13h 28m
Multiple Airlines
Wed 6/175:30 pm
RDU
- FSD
1 stop25h 31m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:24 am
FSD
- RDU
1 stop6h 20m
Delta
Wed 6/171:49 pm
RDU
- FSD
1 stop7h 10m
Delta
Deal found 5/10![Delta logo]()
$365
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 12, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 12, 2026.
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:58 am
FSD
- RDU
1 stop5h 54m
Delta
Mon 9/141:00 pm
RDU
- FSD
2 stops10h 09m
Delta
Deal found 5/11![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2312:07 pm
FSD
- RDU
1 stop6h 21m
American Airlines
Fri 5/294:49 pm
RDU
- FSD
1 stop6h 28m
American Airlines
Deal found 5/8![American Airlines logo]()
$386
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:35 am
FSD
- RDU
1 stop5h 26m
United Airlines
Sat 5/303:14 pm
RDU
- FSD
2 stops9h 12m
United Airlines
Deal found 5/12![United Airlines logo]()
$435
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:20 am
FSD
- RDU
1 stop5h 15m
Delta
Thu 8/136:00 am
RDU
- FSD
1 stop5h 20m
Delta
Deal found 5/9![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:24 am
FSD
- RDU
1 stop6h 20m
Delta
Wed 6/171:49 pm
RDU
- FSD
1 stop7h 10m
Delta
Deal found 5/10![Delta logo]()
$365
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am
FSD
- RDU
1 stop5h 33m
United Airlines
Sat 10/35:30 pm
RDU
- FSD
1 stop5h 13m
United Airlines
Deal found 5/11![United Airlines logo]()
$489
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated May 12, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated May 12, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2312:07 pm
FSD
- RDU
1 stop6h 21m
American Airlines
Fri 5/294:49 pm
RDU
- FSD
1 stop6h 28m
American Airlines
Deal found 5/8![American Airlines logo]()
$386
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:35 pm
FSD
- RDU
2 stops8h 51m
Delta
Fri 5/296:00 am
RDU
- FSD
1 stop5h 15m
Delta
Deal found 5/8![Delta logo]()
$389
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
FSD
- RDU
1 stop6h 23m
American Airlines
Sat 5/3011:39 am
RDU
- FSD
1 stop6h 16m
American Airlines
Deal found 5/8![American Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
FSD
- RDU
1 stop6h 23m
American Airlines
Sat 6/66:11 pm
RDU
- FSD
1 stop6h 45m
American Airlines
Deal found 5/11![American Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:24 am
FSD
- RDU
1 stop6h 20m
Delta
Wed 6/171:49 pm
RDU
- FSD
1 stop7h 10m
Delta
Deal found 5/10![Delta logo]()
$365
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:06 pm
FSD
- RDU
2 stops41h 57m
Multiple Airlines
Wed 6/175:30 pm
RDU
- FSD
1 stop25h 31m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:51 pm
FSD
- RDU
1 stop13h 28m
Multiple Airlines
Wed 6/175:30 pm
RDU
- FSD
1 stop25h 31m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:14 pm
FSD
- RDU
1 stop19h 05m
Multiple Airlines
Wed 6/175:30 pm
RDU
- FSD
1 stop25h 31m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$331
One-way flights from Sioux Falls to DurhamSearch for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated May 12, 2026.
Search for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated May 12, 2026.
This Expedia deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/298:14 pm
FSD
- RDU
1 stop14h 17m
Frontier
Deal found 5/8![Frontier logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:14 pm
FSD
- RDU
1 stop19h 05m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:51 pm
FSD
- RDU
1 stop13h 09m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/286:51 pm
FSD
- RDU
1 stop13h 28m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/88:42 pm
FSD
- RDU
2 stops37h 49m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/298:42 pm
FSD
- RDU
2 stops37h 49m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/84:25 pm
FSD
- RDU
2 stops31h 04m
Frontier
Deal found 5/12![Frontier logo]()
$204
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated May 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $311 (American Airlines) |
One-way from | $154 (Expedia) |
Popular in | March |
Cheapest in | August |
Average price | $365 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 12, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/9
10:58 am-5:52 pm
1 stop5h 54m
Raleigh-Durham
Mon 9/14
1:00 pm-10:09 pm
2 stops10h 09m
$335
Quickest round-trip
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Thu 7/30
5:20 am-11:35 am
1 stop5h 15m
Raleigh-Durham
Thu 8/13
6:00 am-10:20 am
1 stop5h 20m
$349
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 6/10
5:24 am-12:44 pm
1 stop6h 20m
Raleigh-Durham
Wed 6/17
1:49 pm-7:59 pm
1 stop7h 10m
$365
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sat 5/23
12:07 pm-7:28 pm
1 stop6h 21m
Raleigh-Durham
Fri 5/29
4:49 pm-10:17 pm
1 stop6h 28m
$386
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sun 5/24
7:35 am-2:01 pm
1 stop5h 26m
Raleigh-Durham
Sat 5/30
3:14 pm-11:26 pm
2 stops9h 12m
$435
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/30
6:00 am-12:33 pm
1 stop5h 33m
Raleigh-Durham
Sat 10/3
5:30 pm-9:43 pm
1 stop5h 13m
$489
Cheapest one-way
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Mon 6/29
8:14 pm-11:31 am
1 stop14h 17m
$154
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Tue 6/9
1:14 pm-9:19 am
1 stop19h 05m
$167
Quickest one-way
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sun 6/7
6:51 pm-9:00 am
1 stop13h 09m
$169
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Mon 6/8
4:25 pm-12:29 am
2 stops31h 04m
$204
Showing 1-10 of 13 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
How much does it cost to fly round-trip from Sioux Falls to Durham?
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated May 12, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Find flights from Sioux Falls to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on May 12, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on May 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$358 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$498 | FlexibilityNo cancel fee | On-time69% |