$249+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
Sep 29 — Oct 61
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to Durham
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Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 30, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 30, 2026.
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop9h 05m
Sat 9/126:00 am -
1 stop6h 36m
Deal found 8/27![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:18 pm -
1 stop6h 27m
Fri 10/238:25 pm -
1 stop5h 16m
Deal found 8/27![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:07 pm -
1 stop6h 38m
Sun 11/18:15 pm -
1 stop5h 14m
Deal found 8/26![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:48 pm -
2 stops8h 09m
Sat 10/105:02 am -
2 stops7h 37m
Deal found 8/27![American Airlines logo]()
$331
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:40 am -
1 stop6h 11m
Wed 9/161:42 pm -
1 stop7h 05m
Deal found 8/25![Delta logo]()
$342
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:23 pm -
1 stop5h 19m
Thu 9/107:47 pm -
1 stop5h 42m
Deal found 8/28![American Airlines logo]()
$350
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/242:18 pm -
1 stop7h 18m
Wed 12/301:51 pm -
1 stop6h 12m
Deal found 8/25![American Airlines logo]()
$381
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 30, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 30, 2026.
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:48 pm -
1 stop6h 00m
Sat 10/105:02 am -
2 stops7h 37m
Deal found 8/27![American Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:40 am -
1 stop6h 11m
Wed 9/161:42 pm -
1 stop7h 05m
Deal found 8/25![Delta logo]()
$342
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:50 am -
1 stop7h 13m
Sat 10/34:27 pm -
1 stop8h 17m
Deal found 8/29![United Airlines logo]()
$411
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:53 pm -
2 stops8h 40m
Fri 10/238:25 pm -
1 stop5h 16m
Deal found 8/27![American Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:29 pm -
1 stop7h 24m
Sun 11/88:15 pm -
1 stop5h 14m
Deal found 8/25![American Airlines logo]()
$401
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated August 30, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated August 30, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:23 pm -
1 stop5h 19m
Thu 9/107:47 pm -
1 stop5h 42m
Deal found 8/28![American Airlines logo]()
$350
This Delta deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:30 am -
1 stop7h 49m
Thu 9/106:56 pm -
1 stop4h 55m
Deal found 8/26![Delta logo]()
$390
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:23 pm -
1 stop5h 19m
Tue 9/156:23 pm -
1 stop7h 06m
Deal found 8/28![American Airlines logo]()
$406
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop9h 05m
Sat 9/126:00 am -
1 stop6h 36m
Deal found 8/27![American Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:40 am -
1 stop6h 11m
Wed 9/161:42 pm -
1 stop7h 05m
Deal found 8/25![Delta logo]()
$342
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:50 am -
1 stop7h 13m
Sat 10/34:27 pm -
1 stop8h 17m
Deal found 8/26![United Airlines logo]()
$411
One-way flights from Sioux Falls to DurhamSearch for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated August 30, 2026.
Search for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated August 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/11:56 pm -
3 stops55h 53m
Deal found 8/27![Multiple Airlines logo]()
$249
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:15 am -
1 stop6h 33m
Deal found 8/27![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
2 stops8h 54m
Deal found 8/27![American Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:48 pm -
3 stops50h 34m
Deal found 8/27![Multiple Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:48 pm -
2 stops29h 44m
Deal found 8/28![Multiple Airlines logo]()
$343
This KAYAK deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1912:53 pm -
2 stops10h 04m
Deal found 8/26![American Airlines logo]()
$353
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/911:12 am -
1 stop5h 06m
Deal found 8/28![United Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:47 am -
2 stops12h 13m
Deal found 8/28![United Airlines logo]()
$392
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:00 am -
2 stops12h 05m
Deal found 8/26![American Airlines logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/261:38 pm -
3 stops51h 27m
Deal found 8/26![Multiple Airlines logo]()
$771
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated August 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $321 (American Airlines) |
One-way from | $249 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $364 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 30, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Tue 10/6
2:48 pm-9:48 pm
1 stop6h 00m
Raleigh-Durham
Sat 10/10
5:02 am-11:39 am
2 stops7h 37m
$326
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Sat 10/17
12:53 pm-10:33 pm
2 stops8h 40m
Raleigh-Durham
Fri 10/23
8:25 pm-12:41 am
1 stop5h 16m
$330
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 9/11
10:40 am-5:51 pm
1 stop6h 11m
Raleigh-Durham
Wed 9/16
1:42 pm-7:47 pm
1 stop7h 05m
$342
Quickest round-trip
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 11/6
3:29 pm-11:53 pm
1 stop7h 24m
Raleigh-Durham
Sun 11/8
8:15 pm-12:29 am
1 stop5h 14m
$401
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/30
7:50 am-4:03 pm
1 stop7h 13m
Raleigh-Durham
Sat 10/3
4:27 pm-11:44 pm
1 stop8h 17m
$411
Cheapest one-way
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Sun 11/1
1:56 pm-10:49 pm
3 stops55h 53m
$249
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Sun 11/1
1:08 pm-8:56 pm
1 stop6h 48m
$309
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Mon 10/19
7:50 am-1:49 pm
1 stop4h 59m
$309
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/30
11:15 am-6:48 pm
1 stop6h 33m
$309
Quickest one-way
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Thu 11/26
12:11 pm-5:57 pm
1 stop4h 46m
$309
Showing 1-10 of 15 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
How much does it cost to fly round-trip from Sioux Falls to Durham?
Airfare is typical for this route at the moment.
Sioux Falls to Durham flights typically cost between $270 and $448 in September.The cheapest round-trip price found within the last 5 days was $321 on American Airlines (Sep 9-Sep 12).
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated August 30, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Sioux Falls to Durham
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Complete your trip
Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Sioux Falls to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on August 30, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on August 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$271 | Average$412 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$511 | FlexibilityNo cancel fee | On-time69% |