$138+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
Sep 21 — Sep 281
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 22, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 22, 2026.
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop6h 27m
Sat 9/126:00 am -
1 stop7h 16m
Deal found 8/17![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:56 pm -
1 stop7h 08m
Tue 9/227:47 pm -
1 stop5h 42m
Deal found 8/18![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:00 am -
1 stop7h 03m
Mon 11/236:00 am -
1 stop7h 31m
Deal found 8/21![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:05 am -
2 stops8h 42m
Sat 10/105:02 am -
2 stops7h 37m
Deal found 8/17![American Airlines logo]()
$331
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:48 am -
1 stop4h 56m
Mon 11/233:00 pm -
2 stops7h 37m
Deal found 8/21![United Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:05 am -
1 stop4h 31m
Wed 9/236:56 pm -
1 stop4h 55m
Deal found 8/19![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:30 am -
1 stop7h 24m
Wed 9/161:42 pm -
1 stop7h 05m
Deal found 8/19![Delta logo]()
$342
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:06 pm -
1 stop5h 43m
Wed 9/235:00 pm -
1 stop7h 12m
Deal found 8/19![United Airlines logo]()
$377
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 22, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 22, 2026.
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:12 am -
1 stop5h 12m
Wed 9/235:00 pm -
1 stop7h 12m
Deal found 8/19![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:05 am -
2 stops8h 42m
Sat 10/1011:39 am -
1 stop6h 44m
Deal found 8/21![American Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:23 am -
1 stop4h 45m
Sat 10/103:34 pm -
1 stop5h 21m
Deal found 8/18![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:48 am -
1 stop7h 29m
Sat 11/215:24 pm -
1 stop5h 13m
Deal found 8/21![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:00 am -
1 stop7h 03m
Mon 11/236:00 am -
1 stop7h 31m
Deal found 8/21![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:48 am -
1 stop4h 56m
Tue 12/15:30 pm -
1 stop5h 13m
Deal found 8/17![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
2 stops9h 54m
Sat 9/1212:06 pm -
2 stops9h 39m
Deal found 8/20![American Airlines logo]()
$360
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:48 am -
1 stop4h 56m
Mon 11/233:00 pm -
2 stops7h 37m
Deal found 8/21![United Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:50 am -
1 stop7h 13m
Sat 10/34:27 pm -
1 stop8h 17m
Deal found 8/21![United Airlines logo]()
$411
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated August 22, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated August 22, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:24 am -
1 stop7h 53m
Wed 9/236:23 pm -
1 stop7h 06m
Deal found 8/19![American Airlines logo]()
$405
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:06 pm -
1 stop5h 43m
Wed 9/235:00 pm -
1 stop7h 12m
Deal found 8/19![United Airlines logo]()
$377
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2512:06 pm -
2 stops9h 47m
Wed 9/237:47 pm -
1 stop5h 42m
Deal found 8/19![American Airlines logo]()
$382
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop6h 27m
Sat 9/126:00 am -
1 stop7h 16m
Deal found 8/17![American Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:30 am -
1 stop7h 24m
Wed 9/161:42 pm -
1 stop7h 05m
Deal found 8/19![Delta logo]()
$342
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:56 pm -
1 stop7h 08m
Tue 9/227:47 pm -
1 stop5h 42m
Deal found 8/18![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:05 am -
1 stop4h 31m
Wed 9/236:56 pm -
1 stop4h 55m
Deal found 8/19![Delta logo]()
$339
One-way flights from Sioux Falls to DurhamSearch for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated August 22, 2026.
Search for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated August 22, 2026.
This Jetabroad deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jetabroad is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:56 pm -
1 stop21h 13m
Deal found 8/20![Frontier logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3111:58 am -
2 stops20h 54m
Deal found 8/20![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:00 pm -
2 stops36h 21m
Deal found 8/19![Multiple Airlines logo]()
$301
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
1 stop8h 21m
Deal found 8/19![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:06 pm -
1 stop6h 41m
Deal found 8/17![American Airlines logo]()
$384
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated August 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $321 (American Airlines) |
One-way from | $138 (Jetabroad) |
Popular in | June |
Cheapest in | October |
Average price | $364 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 22, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/16
11:12 am-5:24 pm
1 stop5h 12m
Raleigh-Durham
Wed 9/23
5:00 pm-11:12 pm
1 stop7h 12m
$325
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 11/20
7:48 am-4:17 pm
1 stop7h 29m
Raleigh-Durham
Sat 11/21
5:24 pm-9:37 pm
1 stop5h 13m
$325
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Sun 11/22
7:48 am-1:44 pm
1 stop4h 56m
Raleigh-Durham
Tue 12/1
5:30 pm-9:43 pm
1 stop5h 13m
$325
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Tue 10/6
7:05 am-4:47 pm
2 stops8h 42m
Raleigh-Durham
Sat 10/10
11:39 am-5:23 pm
1 stop6h 44m
$326
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Thu 11/19
7:00 am-3:03 pm
1 stop7h 03m
Raleigh-Durham
Mon 11/23
6:00 am-12:31 pm
1 stop7h 31m
$329
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Thu 11/19
7:48 am-1:44 pm
1 stop4h 56m
Raleigh-Durham
Mon 11/23
3:00 pm-9:37 pm
2 stops7h 37m
$334
Quickest round-trip
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Fri 10/2
8:23 am-2:08 pm
1 stop4h 45m
Raleigh-Durham
Sat 10/10
3:34 pm-7:55 pm
1 stop5h 21m
$339
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/9
6:00 am-4:54 pm
2 stops9h 54m
Raleigh-Durham
Sat 9/12
12:06 pm-8:45 pm
2 stops9h 39m
$360
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/30
7:50 am-4:03 pm
1 stop7h 13m
Raleigh-Durham
Sat 10/3
4:27 pm-11:44 pm
1 stop8h 17m
$411
Cheapest one-way
Sioux FallsRaleigh
FSD Sioux Falls Joe Foss Field - RDU Raleigh-Durham
FSDRDU
Sioux Falls Joe Foss Field
Mon 8/31
11:58 am-9:52 am
2 stops20h 54m
$207
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
How much does it cost to fly round-trip from Sioux Falls to Durham?
Airfare is typical for this route at the moment.
Sioux Falls to Durham flights typically cost between $301 and $456 in September.The cheapest round-trip price found within the last 5 days was $321 on American Airlines (Sep 9-Sep 12).
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated August 22, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Food
7.2
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Food
7.2
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Food
7.2
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on August 22, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on August 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$271 | Average$409 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$511 | FlexibilityNo cancel fee | On-time69% |