$134+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
May 29 — Jun 51
Round-trip
1 adult, Economy
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Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:25 am
FSD
- RDU
1 stop6h 36m
Delta
Sat 9/123:15 pm
RDU
- FSD
1 stop4h 51m
Delta
Deal found 4/25![Delta logo]()
$311
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:25 am
FSD
- RDU
1 stop6h 24m
Delta
Sat 10/103:30 pm
RDU
- FSD
1 stop7h 42m
Delta
Deal found 4/28![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:46 pm
FSD
- RDU
1 stop5h 49m
American Airlines
Sat 5/306:11 pm
RDU
- FSD
1 stop5h 46m
American Airlines
Deal found 4/24![American Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:35 pm
FSD
- RDU
2 stops20h 53m
Multiple Airlines
Sun 5/1711:47 am
RDU
- FSD
1 stop30h 34m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:35 pm
FSD
- RDU
2 stops9h 43m
Delta
Sat 5/306:00 am
RDU
- FSD
1 stop7h 49m
Delta
Deal found 4/26![Delta logo]()
$330
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:20 am
FSD
- RDU
2 stops8h 42m
Delta
Tue 6/29:37 am
RDU
- FSD
2 stops11h 12m
Delta
Deal found 4/28![Delta logo]()
$336
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
FSD
- RDU
1 stop7h 01m
United Airlines
Sat 5/305:12 pm
RDU
- FSD
1 stop6h 00m
United Airlines
Deal found 4/26![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:20 am
FSD
- RDU
1 stop5h 32m
Delta
Sat 5/306:00 am
RDU
- FSD
1 stop7h 49m
Delta
Deal found 4/27![Delta logo]()
$345
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:41 pm
FSD
- RDU
1 stop6h 29m
American Airlines
Sat 5/163:54 pm
RDU
- FSD
1 stop8h 12m
American Airlines
Deal found 4/24![American Airlines logo]()
$354
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:20 am
FSD
- RDU
2 stops8h 42m
Delta
Tue 6/26:00 am
RDU
- FSD
1 stop5h 15m
Delta
Deal found 4/28![Delta logo]()
$330
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
FSD
- RDU
1 stop7h 01m
United Airlines
Sat 5/305:12 pm
RDU
- FSD
1 stop6h 00m
United Airlines
Deal found 4/26![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:35 pm
FSD
- RDU
2 stops9h 43m
Delta
Sat 5/306:00 am
RDU
- FSD
1 stop7h 49m
Delta
Deal found 4/26![Delta logo]()
$330
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:15 am
FSD
- RDU
1 stop5h 12m
Delta
Mon 9/286:40 pm
RDU
- FSD
1 stop5h 06m
Delta
Deal found 4/27![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:20 am
FSD
- RDU
1 stop7h 16m
Delta
Sat 5/305:20 am
RDU
- FSD
2 stops8h 29m
Delta
Deal found 4/25![Delta logo]()
$350
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:00 am
FSD
- RDU
1 stop4h 36m
Delta
Sun 5/316:00 am
RDU
- FSD
1 stop5h 15m
Delta
Deal found 4/25![Delta logo]()
$409
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated April 29, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated April 29, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:41 pm
FSD
- RDU
1 stop6h 29m
American Airlines
Sat 5/163:54 pm
RDU
- FSD
1 stop8h 12m
American Airlines
Deal found 4/24![American Airlines logo]()
$354
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:35 pm
FSD
- RDU
2 stops20h 53m
Multiple Airlines
Sun 5/1711:47 am
RDU
- FSD
1 stop30h 34m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$326
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:52 am
FSD
- RDU
1 stop5h 05m
American Airlines
Sun 5/175:00 am
RDU
- FSD
1 stop8h 56m
American Airlines
Deal found 4/28![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:20 am
FSD
- RDU
2 stops8h 42m
Delta
Tue 6/29:37 am
RDU
- FSD
2 stops11h 12m
Delta
Deal found 4/28![Delta logo]()
$336
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:46 pm
FSD
- RDU
1 stop5h 49m
American Airlines
Sat 5/306:11 pm
RDU
- FSD
1 stop5h 46m
American Airlines
Deal found 4/24![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:35 pm
FSD
- RDU
2 stops9h 43m
Delta
Sat 5/306:00 am
RDU
- FSD
1 stop7h 49m
Delta
Deal found 4/26![Delta logo]()
$330
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
FSD
- RDU
1 stop7h 01m
United Airlines
Sat 5/305:12 pm
RDU
- FSD
1 stop6h 00m
United Airlines
Deal found 4/26![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:20 am
FSD
- RDU
1 stop5h 32m
Delta
Sat 5/306:00 am
RDU
- FSD
1 stop7h 49m
Delta
Deal found 4/26![Delta logo]()
$311
One-way flights from Sioux Falls to DurhamSearch for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
Search for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
This Expedia deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:14 pm
FSD
- RDU
1 stop14h 17m
Frontier
Deal found 4/28![Frontier logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:07 pm
FSD
- RDU
2 stops35h 12m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:51 pm
FSD
- RDU
1 stop13h 09m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$212
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/144:26 pm
FSD
- RDU
2 stops7h 16m
Delta
Deal found 4/28![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:17 am
FSD
- RDU
1 stop7h 24m
United Airlines
Deal found 4/28![United Airlines logo]()
$348
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated April 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $311 (Delta) |
One-way from | $134 (Expedia) |
Popular in | April |
Cheapest in | August |
Average price | $523 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Thu 5/21
5:20 am-3:02 pm
2 stops8h 42m
Raleigh-Durham
Tue 6/2
6:00 am-10:15 am
1 stop5h 15m
$330
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sat 5/23
1:35 pm-12:18 am
2 stops9h 43m
Raleigh-Durham
Sat 5/30
6:00 am-12:49 pm
1 stop7h 49m
$330
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sat 5/23
6:00 am-2:01 pm
1 stop7h 01m
Raleigh-Durham
Sat 5/30
5:12 pm-10:12 pm
1 stop6h 00m
$339
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Fri 9/25
5:15 am-11:27 am
1 stop5h 12m
Raleigh-Durham
Mon 9/28
6:40 pm-10:46 pm
1 stop5h 06m
$339
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sun 5/24
5:20 am-1:36 pm
1 stop7h 16m
Raleigh-Durham
Sat 5/30
5:20 am-12:49 pm
2 stops8h 29m
$350
Quickest round-trip
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Thu 5/28
5:00 am-10:36 am
1 stop4h 36m
Raleigh-Durham
Sun 5/31
6:00 am-10:15 am
1 stop5h 15m
$409
Cheapest one-way
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Mon 6/15
8:14 pm-11:31 am
1 stop14h 17m
$134
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Mon 6/15
9:07 pm-9:19 am
2 stops35h 12m
$157
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sun 6/14
6:51 pm-9:00 am
1 stop13h 09m
$212
Quickest one-way
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sun 6/14
4:26 pm-12:42 am
2 stops7h 16m
$319
Showing 1-10 of 11 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
How much does it cost to fly round-trip from Sioux Falls to Durham?
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated April 29, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Entertainment
7.8
Crew
8.5
Comfort
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Entertainment
7.8
Crew
8.5
Comfort
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Entertainment
7.8
Crew
8.5
Comfort
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Entertainment
7.8
Crew
8.5
Comfort
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Sioux Falls to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on April 29, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on April 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$368 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$345 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$498 | FlexibilityNo cancel fee | On-time69% |