$200+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
Jun 6 — Jun 131
Round-trip
1 adult, Economy
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Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.
This Trip.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:18 pm
FSD
- RDU
1 stop15h 13m
Frontier
Sun 5/2412:26 pm
RDU
- FSD
1 stop28h 14m
Frontier
Deal found 5/5![Frontier logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:08 pm
FSD
- RDU
1 stop14h 51m
Multiple Airlines
Mon 6/87:53 pm
RDU
- FSD
1 stop17h 31m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 pm
FSD
- RDU
1 stop4h 27m
American Airlines
Sat 9/126:30 am
RDU
- FSD
1 stop6h 16m
American Airlines
Deal found 5/5![American Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:24 am
FSD
- RDU
1 stop6h 20m
Delta
Wed 6/1712:49 pm
RDU
- FSD
1 stop8h 10m
Delta
Deal found 5/6![Delta logo]()
$321
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:06 am
FSD
- RDU
2 stops9h 30m
American Airlines
Tue 7/284:15 pm
RDU
- FSD
2 stops9h 03m
American Airlines
Deal found 5/3![American Airlines logo]()
$322
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:46 pm
FSD
- RDU
1 stop6h 08m
American Airlines
Tue 6/26:20 pm
RDU
- FSD
1 stop5h 48m
American Airlines
Deal found 5/5![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:20 am
FSD
- RDU
1 stop5h 15m
Delta
Mon 7/2711:33 am
RDU
- FSD
1 stop5h 08m
Delta
Deal found 5/3![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:16 pm
FSD
- RDU
1 stop6h 24m
Delta
Wed 6/106:00 am
RDU
- FSD
1 stop5h 16m
Delta
Deal found 5/4![Delta logo]()
$345
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 7, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 7, 2026.
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:24 am
FSD
- RDU
1 stop6h 20m
Delta
Wed 6/1712:49 pm
RDU
- FSD
1 stop8h 10m
Delta
Deal found 5/6![Delta logo]()
$321
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:40 am
FSD
- RDU
1 stop5h 21m
United Airlines
Sat 7/115:12 pm
RDU
- FSD
1 stop7h 19m
United Airlines
Deal found 5/4![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:46 pm
FSD
- RDU
1 stop6h 08m
American Airlines
Sat 5/3011:39 am
RDU
- FSD
1 stop6h 16m
American Airlines
Deal found 5/2![American Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:20 am
FSD
- RDU
1 stop5h 15m
Delta
Mon 7/2711:33 am
RDU
- FSD
1 stop5h 08m
Delta
Deal found 5/3![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:30 am
FSD
- RDU
1 stop5h 39m
United Airlines
Sun 5/245:12 pm
RDU
- FSD
1 stop7h 14m
United Airlines
Deal found 5/3![United Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:26 pm
FSD
- RDU
1 stop6h 33m
Delta
Tue 7/286:00 am
RDU
- FSD
1 stop5h 15m
Delta
Deal found 5/3![Delta logo]()
$345
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:16 pm
FSD
- RDU
1 stop6h 24m
Delta
Wed 6/106:00 am
RDU
- FSD
1 stop5h 16m
Delta
Deal found 5/4![Delta logo]()
$345
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:19 am
FSD
- RDU
2 stops7h 34m
Delta
Tue 6/212:57 pm
RDU
- FSD
1 stop7h 52m
Delta
Deal found 5/5![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:20 am
FSD
- RDU
2 stops8h 42m
Delta
Tue 6/29:37 am
RDU
- FSD
2 stops11h 12m
Delta
Deal found 5/5![Delta logo]()
$369
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated May 7, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated May 7, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:18 pm
FSD
- RDU
1 stop15h 13m
Frontier
Sun 5/2412:26 pm
RDU
- FSD
1 stop28h 14m
Frontier
Deal found 5/5![Frontier logo]()
$267
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:30 am
FSD
- RDU
1 stop5h 39m
United Airlines
Sun 5/245:12 pm
RDU
- FSD
1 stop7h 14m
United Airlines
Deal found 5/3![United Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:41 pm
FSD
- RDU
1 stop6h 29m
American Airlines
Sun 5/243:12 pm
RDU
- FSD
2 stops8h 45m
American Airlines
Deal found 5/3![American Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:46 pm
FSD
- RDU
1 stop6h 08m
American Airlines
Tue 6/26:20 pm
RDU
- FSD
1 stop5h 48m
American Airlines
Deal found 5/5![American Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:08 pm
FSD
- RDU
1 stop14h 51m
Multiple Airlines
Mon 6/87:53 pm
RDU
- FSD
1 stop17h 31m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:16 pm
FSD
- RDU
1 stop6h 24m
Delta
Wed 6/106:00 am
RDU
- FSD
1 stop5h 16m
Delta
Deal found 5/4![Delta logo]()
$345
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:24 am
FSD
- RDU
1 stop6h 20m
Delta
Wed 6/1712:49 pm
RDU
- FSD
1 stop8h 10m
Delta
Deal found 5/6![Delta logo]()
$321
One-way flights from Sioux Falls to DurhamSearch for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated May 7, 2026.
Search for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated May 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:35 am
FSD
- RDU
1 stop20h 46m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$200
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:20 am
FSD
- RDU
1 stop5h 32m
Delta
Deal found 5/5![Delta logo]()
$314
This KAYAK deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:46 pm
FSD
- RDU
1 stop6h 08m
American Airlines
Deal found 5/7![American Airlines logo]()
$379
This KAYAK deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:00 am
FSD
- RDU
1 stop5h 16m
United Airlines
Deal found 5/6![United Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:35 pm
FSD
- RDU
1 stop8h 15m
United Airlines
Deal found 5/5![United Airlines logo]()
$447
This KAYAK deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:16 am
FSD
- RDU
2 stops11h 13m
United Airlines
Deal found 5/7![United Airlines logo]()
$480
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
FSD
- RDU
1 stop14h 37m
United Airlines
Deal found 5/5![United Airlines logo]()
$535
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated May 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $267 (Trip.com) |
One-way from | $200 (Kiwi.com) |
Popular in | April |
Cheapest in | August |
Average price | $378 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 6/10
5:24 am-12:44 pm
1 stop6h 20m
Raleigh-Durham
Wed 6/17
12:49 pm-7:59 pm
1 stop8h 10m
$321
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 7/1
7:40 am-2:01 pm
1 stop5h 21m
Raleigh-Durham
Sat 7/11
5:12 pm-11:31 pm
1 stop7h 19m
$325
Quickest round-trip
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Mon 7/13
5:20 am-11:35 am
1 stop5h 15m
Raleigh-Durham
Mon 7/27
11:33 am-3:41 pm
1 stop5h 08m
$339
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Tue 7/14
4:26 pm-11:59 pm
1 stop6h 33m
Raleigh-Durham
Tue 7/28
6:00 am-10:15 am
1 stop5h 15m
$345
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 6/3
4:16 pm-11:40 pm
1 stop6h 24m
Raleigh-Durham
Wed 6/10
6:00 am-10:16 am
1 stop5h 16m
$345
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 5/20
7:30 am-2:09 pm
1 stop5h 39m
Raleigh-Durham
Sun 5/24
5:12 pm-11:26 pm
1 stop7h 14m
$354
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Thu 5/21
8:19 am-4:53 pm
2 stops7h 34m
Raleigh-Durham
Tue 6/2
12:57 pm-7:49 pm
1 stop7h 52m
$359
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Thu 5/28
5:20 am-3:02 pm
2 stops8h 42m
Raleigh-Durham
Tue 6/2
9:37 am-7:49 pm
2 stops11h 12m
$369
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Sun 5/24
4:46 pm-11:54 pm
1 stop6h 08m
Raleigh-Durham
Sat 5/30
11:39 am-4:55 pm
1 stop6h 16m
$409
Cheapest one-way
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Thu 5/28
5:20 am-11:52 am
1 stop5h 32m
$314
Showing 1-10 of 16 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
How much does it cost to fly round-trip from Sioux Falls to Durham?
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated May 7, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.9
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Entertainment
7.8
Comfort
7.9
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Entertainment
7.8
Comfort
7.9
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Entertainment
7.8
Comfort
7.9
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Find flights from Sioux Falls to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on May 7, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on May 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$368 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$355 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$498 | FlexibilityNo cancel fee | On-time69% |