$145+ Cheap flights from Sioux Falls (FSD) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — RDU
Aug 22 — Aug 291
Round-trip
1 adult, Economy
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Best
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Cheapest flights from Sioux Falls to DurhamExplore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
Explore the most affordable flight options available from Sioux Falls to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
This Expedia deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:08 pm
FSD
- RDU
1 stop14h 23m
Frontier
Fri 8/712:26 pm
RDU
- FSD
1 stop7h 57m
Frontier
Deal found 7/20![Frontier logo]()
$246
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
FSD
- RDU
1 stop9h 05m
American Airlines
Sat 9/126:00 am
RDU
- FSD
1 stop6h 36m
American Airlines
Deal found 7/19![American Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:23 pm
FSD
- RDU
1 stop5h 19m
American Airlines
Fri 8/287:04 am
RDU
- FSD
1 stop5h 32m
American Airlines
Deal found 7/22![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:00 pm
FSD
- RDU
1 stop4h 22m
Delta
Sat 10/101:47 pm
RDU
- FSD
1 stop7h 09m
Delta
Deal found 7/20![Delta logo]()
$325
Best flights from Sioux Falls to DurhamDiscover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
Discover carefully curated flight deals from Sioux Falls to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
This Delta deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:00 pm
FSD
- RDU
1 stop4h 22m
Delta
Sat 10/101:47 pm
RDU
- FSD
1 stop7h 09m
Delta
Deal found 7/18![Delta logo]()
$311
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
FSD
- RDU
1 stop9h 05m
American Airlines
Sat 9/1212:06 pm
RDU
- FSD
2 stops9h 39m
American Airlines
Deal found 7/18![American Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:08 pm
FSD
- RDU
2 stops26h 56m
Frontier
Fri 8/712:26 pm
RDU
- FSD
1 stop7h 57m
Frontier
Deal found 7/20![Frontier logo]()
$484
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:50 am
FSD
- RDU
1 stop4h 59m
United Airlines
Mon 10/125:01 pm
RDU
- FSD
1 stop7h 10m
United Airlines
Deal found 7/19![United Airlines logo]()
$493
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:57 pm
FSD
- RDU
2 stops8h 56m
American Airlines
Fri 8/2812:09 pm
RDU
- FSD
2 stops9h 22m
American Airlines
Deal found 7/22![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/214:09 pm
FSD
- RDU
1 stop6h 44m
Delta
Mon 12/286:00 am
RDU
- FSD
1 stop7h 11m
Delta
Deal found 7/18![Delta logo]()
$359
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:23 pm
FSD
- RDU
1 stop5h 19m
American Airlines
Mon 8/173:36 pm
RDU
- FSD
2 stops9h 54m
American Airlines
Deal found 7/22![American Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:03 am
FSD
- RDU
2 stops8h 44m
American Airlines
Sat 10/106:42 am
RDU
- FSD
2 stops8h 36m
American Airlines
Deal found 7/18![American Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:31 pm
FSD
- RDU
1 stop15h 17m
United Airlines
Fri 10/25:01 pm
RDU
- FSD
1 stop18h 28m
United Airlines
Deal found 7/20![United Airlines logo]()
$664
Last-minute flights from Sioux Falls to DurhamDiscover last-minute flight deals from Sioux Falls to Durham. Data last updated July 23, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Durham. Data last updated July 23, 2026 and is based on user searches.
This KAYAK deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/244:43 pm
FSD
- RDU
1 stop6h 16m
American Airlines
Thu 7/305:16 am
RDU
- FSD
1 stop7h 54m
American Airlines
Deal found 7/20![American Airlines logo]()
$469
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:23 am
FSD
- RDU
1 stop4h 28m
Delta
Sun 8/26:00 am
RDU
- FSD
1 stop5h 15m
Delta
Deal found 7/22![Delta logo]()
$470
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:43 pm
FSD
- RDU
1 stop6h 16m
American Airlines
Tue 8/47:14 pm
RDU
- FSD
1 stop6h 04m
American Airlines
Deal found 7/20![American Airlines logo]()
$441
This Expedia deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:08 pm
FSD
- RDU
1 stop14h 23m
Frontier
Fri 8/712:26 pm
RDU
- FSD
1 stop7h 57m
Frontier
Deal found 7/20![Frontier logo]()
$246
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:23 pm
FSD
- RDU
1 stop5h 19m
American Airlines
Mon 8/173:36 pm
RDU
- FSD
2 stops9h 54m
American Airlines
Deal found 7/22![American Airlines logo]()
$394
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:08 pm
FSD
- RDU
1 stop22h 01m
Frontier
Fri 8/216:05 am
RDU
- FSD
2 stops14h 56m
Frontier
Deal found 7/21![Frontier logo]()
$449
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:23 pm
FSD
- RDU
1 stop5h 19m
American Airlines
Fri 8/287:04 am
RDU
- FSD
1 stop5h 32m
American Airlines
Deal found 7/22![American Airlines logo]()
$319
One-way flights from Sioux Falls to DurhamSearch for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
Search for one-way flight options from Sioux Falls to Durham. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:31 pm
FSD
- RDU
2 stops18h 36m
Frontier
Deal found 7/20![Frontier logo]()
$145
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am
FSD
- RDU
1 stop6h 27m
American Airlines
Deal found 7/20![American Airlines logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:31 pm
FSD
- RDU
2 stops18h 16m
Frontier
Deal found 7/19![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:31 pm
FSD
- RDU
3 stops19h 43m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:09 pm
FSD
- RDU
3 stops51h 08m
Multiple Airlines
Deal found 7/19![Multiple Airlines logo]()
$243
Find flight deals from Sioux Falls to Durham
Keep the following information in mind while searching for Sioux Falls to Durham flight deals. Data was last updated July 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $246 (Expedia) |
One-way from | $145 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $412 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Sioux Falls to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Tue 10/6
1:00 pm-6:22 pm
1 stop4h 22m
Raleigh-Durham
Sat 10/10
1:47 pm-7:56 pm
1 stop7h 09m
$311
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Wed 9/9
6:00 am-4:05 pm
1 stop9h 05m
Raleigh-Durham
Sat 9/12
12:06 pm-8:45 pm
2 stops9h 39m
$316
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Fri 8/21
12:57 pm-10:53 pm
2 stops8h 56m
Raleigh-Durham
Fri 8/28
12:09 pm-8:31 pm
2 stops9h 22m
$329
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Mon 12/21
4:09 pm-11:53 pm
1 stop6h 44m
Raleigh-Durham
Mon 12/28
6:00 am-12:11 pm
1 stop7h 11m
$359
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Fri 8/14
5:23 pm-11:42 pm
1 stop5h 19m
Raleigh-Durham
Mon 8/17
3:36 pm-12:30 am
2 stops9h 54m
$394
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Tue 10/6
7:03 am-4:47 pm
2 stops8h 44m
Raleigh-Durham
Sat 10/10
6:42 am-2:18 pm
2 stops8h 36m
$403
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Mon 8/3
8:08 pm-12:04 am
2 stops26h 56m
Raleigh-Durham
Fri 8/7
12:26 pm-7:23 pm
1 stop7h 57m
$484
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Thu 10/8
7:50 am-1:49 pm
1 stop4h 59m
Raleigh-Durham
Mon 10/12
5:01 pm-11:11 pm
1 stop7h 10m
$493
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Mon 9/28
6:31 pm-10:48 am
1 stop15h 17m
Raleigh-Durham
Fri 10/2
5:01 pm-10:29 am
1 stop18h 28m
$664
Cheapest one-way
Sioux FallsRaleigh
FSD - RDU
FSDRDU
Sioux Falls Joe Foss Field
Fri 9/11
7:31 pm-3:07 pm
2 stops18h 36m
$145
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Sioux Falls with our price prediction graph.
FSD-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Durham
FSD-DU8
FSD-RDU
How much does it cost to fly round-trip from Sioux Falls to Durham?
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated July 23, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Sioux Falls to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Durham flights
Browse other Sioux Falls and Durham flight options. Last updated on July 23, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on July 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Durham flights
Consider these flights traveling from Sioux Falls to Durham.
Top 3 airlines flying from Sioux Falls to Durham
Discover the top 3 airlines that operate flights from Sioux Falls to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$364 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$473 | FlexibilityNo cancel fee | On-time69% |