Find a great deal and save up to 17% by booking at least 15 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Des Moines to Cheyenne within the next two weeks, with the cheapest ticket starting at $144.
Flights from Des Moines to Cheyenne lean towards being more expensive in October. Prices are generally better when you fly from Des Moines to Cheyenne in April, with the cheapest ticket starting at $57.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Cheyenne as you normally would.