$131+ Cheap flights from St. Louis (STL) to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Feb 7 — Feb 141
1 adult, Economy
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Find cheap flights from St. Louis to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Cayman Islands
Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated January 8, 2026.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $361 (Air Canada) |
One-way from | $131 (Delta) |
Popular in | March |
Cheapest in | September |
Average price | $571 |
Find flight deals from St. Louis to Cayman Islands
Cheapest flights from St. Louis to Cayman IslandsExplore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.
This Air Canada deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:05 pmSTL - GCM
1 stop19h 05mAir Canada
Sat 5/212:25 pmGCM - STL
1 stop7h 39mAir Canada
Deal found 1/7![Air Canada logo]()
$361
This Air Canada deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/104:05 pmSTL - GCM
1 stop19h 20mAir Canada
Tue 1/131:30 pmGCM - STL
1 stop26h 59mAir Canada
Deal found 1/6![Air Canada logo]()
$380
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:00 amSTL - GCM
1 stop5h 24mDelta
Mon 4/2712:45 pmGCM - STL
1 stop10h 48mDelta
Deal found 1/6![Delta logo]()
$392
This Air Canada deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/54:05 pmSTL - GCM
1 stop19h 20mAir Canada
Mon 2/91:30 pmGCM - STL
1 stop26h 59mAir Canada
Deal found 1/7![Air Canada logo]()
$395
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:00 amSTL - GCM
1 stop6h 30mUnited Airlines
Tue 4/281:35 pmGCM - STL
2 stops19h 00mUnited Airlines
Deal found 1/8![United Airlines logo]()
$448
This United Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:25 amSTL - GCM
1 stop6h 20mUnited Airlines
Fri 2/202:50 pmGCM - STL
1 stop7h 50mUnited Airlines
Deal found 1/7![United Airlines logo]()
$462
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:11 pmSTL - GCM
2 stops17h 21mAmerican Airlines
Sat 5/22:10 pmGCM - STL
2 stops9h 38mAmerican Airlines
Deal found 1/7![American Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:54 pmSTL - GCM
2 stops18h 17mAmerican Airlines
Tue 4/2812:00 pmGCM - STL
2 stops20h 28mAmerican Airlines
Deal found 1/8![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:54 pmSTL - GCM
2 stops18h 17mAmerican Airlines
Mon 4/2712:00 pmGCM - STL
1 stop10h 24mAmerican Airlines
Deal found 1/6![American Airlines logo]()
$492
This United Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:40 amSTL - GCM
1 stop6h 50mUnited Airlines
Thu 5/211:35 pmGCM - STL
1 stop8h 31mUnited Airlines
Deal found 1/7![United Airlines logo]()
$514
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.
Fly from
St. Louis
Fly to
Cayman Islands
Route
Depart
Return
Price
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Thu 4/23
4:05 pm-11:10 am
1 stop19h 05m
George Town Owen Roberts Intl
Tue 4/28
12:30 pm-3:24 pm
1 stop26h 54m
$361
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 4/18
4:05 pm-11:10 am
1 stop19h 05m
George Town Owen Roberts Intl
Sat 5/2
12:25 pm-8:04 pm
1 stop7h 39m
$361
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 4/22
6:00 am-11:24 am
1 stop5h 24m
George Town Owen Roberts Intl
Mon 4/27
12:45 pm-11:33 pm
1 stop10h 48m
$392
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Thu 4/23
6:00 am-12:30 pm
1 stop6h 30m
George Town Owen Roberts Intl
Tue 4/28
1:35 pm-8:35 am
2 stops19h 00m
$448
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Mon 2/16
6:25 am-1:45 pm
1 stop6h 20m
George Town Owen Roberts Intl
Fri 2/20
2:50 pm-9:40 pm
1 stop7h 50m
$462
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 4/18
6:11 pm-11:32 am
2 stops17h 21m
George Town Owen Roberts Intl
Sat 5/2
4:03 pm-8:57 am
2 stops16h 54m
$467
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Mon 2/23
6:00 am-12:29 pm
1 stop5h 29m
$131
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 2/22
6:00 am-12:29 pm
1 stop5h 29m
$131
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Mon 2/23
8:22 pm-4:05 pm
2 stops18h 43m
$165
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Mon 2/23
6:00 am-8:15 pm
2 stops13h 15m
$226
Showing 1-10 of 14 results
Best time to book a flight from St. Louis to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to the Cayman Islands
What is the cheapest month to book a flight from St. Louis to Cayman Islands?
Currently, April is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $241). Flying from St. Louis to Cayman Islands in June is currently the most expensive (average of $499). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated January 8, 2026.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Cayman Islands
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from St. Louis to Cayman Islands
Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$605 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$365 | Average$730 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$429 | Average$581 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$439 | Average$612 | FlexibilityNo cancel fee | On-time71% |