$144+ Cheap flights from St. Louis (STL) to the Cayman Islands
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Cayman Islands
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Best
Last-minute
One-way
Cheapest flights from St. Louis to Cayman IslandsExplore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This Orbitz deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/64:05 pm -
1 stop19h 05m
Wed 12/91:10 pm -
1 stop27h 16m
Deal found 9/14![Air Canada logo]()
$387
This Travelocity deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:10 pm -
2 stops45h 35m
Sat 10/3112:10 pm -
1 stop28h 13m
Deal found 9/11![Air Canada logo]()
$397
This Air Canada deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:55 am -
1 stop26h 30m
Mon 10/512:25 pm -
1 stop25h 35m
Deal found 9/15![Air Canada logo]()
$401
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:00 am -
1 stop6h 30m
Thu 10/158:00 am -
1 stop9h 27m
Deal found 9/16![American Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:15 pm -
2 stops14h 40m
Wed 12/98:15 am -
2 stops11h 16m
Deal found 9/14![American Airlines logo]()
$410
This Air Canada deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/48:55 am -
1 stop26h 30m
Sat 10/1011:25 am -
1 stop26h 35m
Deal found 9/12![Air Canada logo]()
$411
This Air Canada deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:10 pm -
2 stops47h 15m
Sat 10/1011:25 am -
1 stop26h 35m
Deal found 9/15![Air Canada logo]()
$414
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:00 am -
1 stop14h 00m
Fri 11/68:23 am -
1 stop14h 24m
Deal found 9/16![American Airlines logo]()
$417
Best flights from St. Louis to Cayman IslandsDiscover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:05 pm -
1 stop20h 05m
Sat 11/71:10 pm -
1 stop27h 16m
Deal found 9/15![Air Canada logo]()
$425
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:20 pm -
2 stops16h 15m
Wed 12/91:30 pm -
1 stop9h 55m
Deal found 9/13![Southwest logo]()
$498
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:00 am -
2 stops10h 30m
Wed 11/45:45 pm -
2 stops19h 25m
Deal found 9/15![United Airlines logo]()
$530
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:29 am -
2 stops11h 31m
Sat 11/78:23 am -
1 stop10h 02m
Deal found 9/15![American Airlines logo]()
$540
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:00 am -
1 stop5h 40m
Fri 10/912:55 pm -
1 stop10h 59m
Deal found 9/12![Delta logo]()
$555
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:00 am -
2 stops10h 30m
Wed 11/45:45 pm -
2 stops22h 58m
Deal found 9/12![United Airlines logo]()
$540
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop5h 40m
Sun 10/41:00 pm -
1 stop10h 42m
Deal found 9/12![Delta logo]()
$641
Last-minute flights from St. Louis to Cayman IslandsDiscover last-minute flight deals from St. Louis to Cayman Islands. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Cayman Islands. Data last updated September 17, 2026 and is based on user searches.
This Air Canada deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:10 pm -
2 stops47h 15m
Sat 10/1011:25 am -
1 stop26h 35m
Deal found 9/15![Air Canada logo]()
$414
This Air Canada deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:55 am -
1 stop26h 30m
Mon 10/512:25 pm -
1 stop25h 35m
Deal found 9/15![Air Canada logo]()
$401
This Travelocity deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:10 pm -
2 stops45h 35m
Sat 10/3112:10 pm -
1 stop28h 13m
Deal found 9/11![Air Canada logo]()
$397
This Air Canada deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/48:55 am -
1 stop26h 30m
Sat 10/1011:25 am -
1 stop26h 35m
Deal found 9/12![Air Canada logo]()
$411
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:00 am -
1 stop6h 30m
Thu 10/158:00 am -
1 stop9h 27m
Deal found 9/16![American Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:00 am -
1 stop14h 00m
Fri 11/68:23 am -
1 stop14h 24m
Deal found 9/16![American Airlines logo]()
$417
This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:05 pm -
1 stop20h 05m
Sat 11/71:10 pm -
1 stop27h 16m
Deal found 9/15![Air Canada logo]()
$425
One-way flights from St. Louis to Cayman IslandsSearch for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This Air Canada deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/162:40 pm -
1 stop19h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Air Canada logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:35 pm -
3 stops20h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:19 pm -
3 stops28h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$483
Find flight deals from St. Louis to Cayman Islands
Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated September 17, 2026.
Round-trip from | $387 (Orbitz) |
|---|---|
One-way from | $144 (Air Canada) |
Popular in | June |
Cheapest in | April |
Average price | $627 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Wed 10/21
8:55 am-11:25 am
1 stop26h 30m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$144
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Fri 10/16
2:40 pm-10:30 am
1 stop19h 50m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$144
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Fri 10/16
6:35 pm-2:50 pm
3 stops20h 15m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$278
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Sat 10/31
4:05 pm-12:10 pm
1 stop20h 05m
George Town Owen Roberts Intl
Sat 11/7
1:10 pm-3:26 pm
1 stop27h 16m
$425
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Wed 10/21
4:19 pm-9:15 pm
3 stops28h 56m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$483
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Sun 12/6
7:20 pm-12:35 pm
2 stops16h 15m
George Town Owen Roberts Intl
Wed 12/9
1:30 pm-10:25 pm
1 stop9h 55m
$498
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Mon 11/2
5:00 am-4:30 pm
2 stops10h 30m
George Town Owen Roberts Intl
Wed 11/4
5:45 pm-12:10 pm
2 stops19h 25m
$530
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Sat 10/31
7:29 am-7:00 pm
2 stops11h 31m
George Town Owen Roberts Intl
Sat 11/7
8:23 am-5:25 pm
1 stop10h 02m
$540
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Wed 10/28
5:00 am-3:30 pm
2 stops10h 30m
George Town Owen Roberts Intl
Wed 11/4
5:45 pm-3:43 pm
2 stops22h 58m
$540
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Mon 10/5
6:00 am-11:40 am
1 stop5h 40m
George Town Owen Roberts Intl
Fri 10/9
12:55 pm-11:54 pm
1 stop10h 59m
$555
Showing 1-10 of 11 resultsSorted by cheapest first
Best time to book a flight from St. Louis to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
STL-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to the Cayman Islands
STL-KY0
STL-GCM
What is the cheapest month to book a flight from St. Louis to Cayman Islands?
Currently, April is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $502). Flying from St. Louis to Cayman Islands in June is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated September 17, 2026.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Overall
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Overall
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Overall
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Overall
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Cayman Islands
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Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from St. Louis to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Cayman Islands flights
Browse other St. Louis and Cayman Islands flight options. Last updated on September 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 4 airlines flying from St. Louis to Cayman Islands
Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$586 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$364 | Average$559 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$422 | Average$679 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$483 | Average$774 | FlexibilityNo cancel fee | On-time63% |