$140+ Cheap flights from St. Louis (STL) to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Feb 3 — Feb 101
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Cayman Islands
Cheapest flights from St. Louis to Cayman IslandsExplore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 4, 2026.
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 4, 2026.
This Delta deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:00 amSTL - GCM
1 stop5h 29mDelta
Tue 2/241:54 pmGCM - STL
1 stop10h 42mDelta
Deal found 1/2![Delta logo]()
$361
This Air Canada deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:05 pmSTL - GCM
1 stop19h 05mAir Canada
Sat 5/212:25 pmGCM - STL
1 stop7h 39mAir Canada
Deal found 1/4![Air Canada logo]()
$376
This Air Canada deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/104:05 pmSTL - GCM
1 stop19h 20mAir Canada
Tue 1/131:30 pmGCM - STL
1 stop26h 59mAir Canada
Deal found 1/3![Air Canada logo]()
$385
This Delta deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:00 amSTL - GCM
1 stop5h 29mDelta
Tue 2/241:54 pmGCM - STL
1 stop6h 45mDelta
Deal found 1/3![Delta logo]()
$391
This Air Canada deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/254:05 pmSTL - GCM
1 stop19h 20mAir Canada
Mon 3/3012:30 pmGCM - STL
1 stop26h 54mAir Canada
Deal found 1/3![Air Canada logo]()
$400
This Southwest deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/175:10 amSTL - GCM
1 stop6h 45mSouthwest
Tue 3/31:50 pmGCM - STL
1 stop6h 50mSouthwest
Deal found 1/1![Southwest logo]()
$443
This Delta deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:00 amSTL - GCM
1 stop5h 29mDelta
Tue 3/31:54 pmGCM - STL
1 stop10h 42mDelta
Deal found 1/2![Delta logo]()
$459
This American Airlines deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:00 amSTL - GCM
1 stop7h 25mAmerican Airlines
Tue 3/31:05 pmGCM - STL
2 stops11h 17mAmerican Airlines
Deal found 1/2![American Airlines logo]()
$464
This American Airlines deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:53 pmSTL - GCM
2 stops18h 18mAmerican Airlines
Sat 5/22:10 pmGCM - STL
2 stops18h 13mAmerican Airlines
Deal found 1/2![American Airlines logo]()
$476
Find flight deals from St. Louis to Cayman Islands
Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated January 4, 2026.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $361 (Delta) |
One-way from | $140 (United Airlines) |
Popular in | March |
Cheapest in | September |
Average price | $571 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 4, 2026.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.
Fly from
St. Louis
Fly to
Cayman Islands
Route
Depart
Return
Price
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 2/17
6:00 am-12:29 pm
1 stop5h 29m
George Town Owen Roberts Intl
Tue 2/24
1:54 pm-11:36 pm
1 stop10h 42m
$361
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 4/18
4:05 pm-11:10 am
1 stop19h 05m
George Town Owen Roberts Intl
Sat 5/2
12:25 pm-8:04 pm
1 stop7h 39m
$376
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 3/25
6:25 am-12:45 pm
1 stop6h 20m
George Town Owen Roberts Intl
Mon 3/30
1:50 pm-8:35 am
1 stop18h 45m
$391
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Thu 2/19
6:00 am-12:29 pm
1 stop5h 29m
George Town Owen Roberts Intl
Tue 2/24
1:54 pm-7:39 pm
1 stop6h 45m
$391
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 2/17
5:10 am-12:55 pm
1 stop6h 45m
George Town Owen Roberts Intl
Tue 3/3
1:50 pm-7:40 pm
1 stop6h 50m
$443
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 2/17
6:00 am-12:29 pm
1 stop5h 29m
George Town Owen Roberts Intl
Tue 3/3
1:54 pm-11:36 pm
1 stop10h 42m
$459
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Mon 4/6
6:00 am-12:30 pm
1 stop6h 30m
$140
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Mon 4/6
7:30 pm-12:10 pm
2 stops16h 40m
$170
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 6/13
1:00 pm-11:30 am
2 stops46h 30m
$187
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 6/13
6:12 pm-11:20 am
1 stop17h 08m
$242
Showing 1-10 of 11 results
Best time to book a flight from St. Louis to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to the Cayman Islands
What is the cheapest month to book a flight from St. Louis to Cayman Islands?
Currently, April is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $241). Flying from St. Louis to Cayman Islands in June is currently the most expensive (average of $499). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated January 4, 2026.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Cayman Islands
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from St. Louis to Cayman Islands
Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$605 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$365 | Average$730 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$429 | Average$581 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$439 | Average$612 | FlexibilityNo cancel fee | On-time71% |