$235+ Cheap flights from St. Louis (STL) to the Cayman Islands
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/29. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Nov 29 — Dec 61
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from St. Louis to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Cayman Islands
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to Cayman IslandsExplore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Justfly.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:05 pm -
1 stop20h 05m
Fri 11/61:10 pm -
1 stop27h 16m
Deal found 10/27![Air Canada logo]()
$471
This Booking.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/94:05 pm -
1 stop19h 05m
Wed 12/161:10 pm -
1 stop27h 16m
Deal found 10/25![Air Canada logo]()
$478
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/93:25 pm -
2 stops20h 10m
Wed 12/161:30 pm -
1 stop6h 55m
Deal found 10/25![Southwest logo]()
$514
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:27 am -
2 stops11h 34m
Wed 12/1612:55 pm -
2 stops9h 46m
Deal found 10/25![American Airlines logo]()
$519
This Mytrip deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:02 pm -
3 stops32h 13m
Wed 12/1611:30 am -
3 stops38h 11m
Deal found 10/25![Multiple Airlines logo]()
$660
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:32 am -
2 stops12h 28m
Fri 11/612:54 pm -
1 stop9h 53m
Deal found 10/28![American Airlines logo]()
$822
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 am -
1 stop7h 00m
Wed 11/45:45 pm -
2 stops24h 14m
Deal found 10/26![United Airlines logo]()
$942
Best flights from St. Louis to Cayman IslandsDiscover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Booking.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/94:05 pm -
1 stop19h 05m
Wed 12/161:10 pm -
1 stop27h 16m
Deal found 10/25![Air Canada logo]()
$478
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/93:25 pm -
2 stops20h 10m
Wed 12/161:30 pm -
1 stop6h 55m
Deal found 10/25![Southwest logo]()
$514
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:27 am -
2 stops11h 34m
Wed 12/1612:55 pm -
2 stops9h 46m
Deal found 10/25![American Airlines logo]()
$519
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/176:00 am -
1 stop7h 05m
Sat 5/12:30 pm -
1 stop9h 09m
Deal found 10/30![Delta logo]()
$574
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/178:50 am -
1 stop6h 40m
Tue 3/231:25 pm -
1 stop9h 33m
Deal found 10/26![United Airlines logo]()
$576
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/225:00 am -
1 stop6h 55m
Sat 2/271:25 pm -
1 stop10h 55m
Deal found 10/29![Southwest logo]()
$573
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/226:00 am -
2 stops8h 14m
Sat 2/2711:50 am -
2 stops12h 56m
Deal found 10/29![American Airlines logo]()
$576
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/175:21 pm -
2 stops18h 11m
Sat 5/112:35 pm -
1 stop6h 55m
Deal found 10/29![American Airlines logo]()
$578
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/95:21 pm -
2 stops17h 39m
Fri 4/162:10 pm -
2 stops18h 47m
Deal found 10/27![American Airlines logo]()
$580
Last-minute flights from St. Louis to Cayman IslandsDiscover last-minute flight deals from St. Louis to Cayman Islands. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Cayman Islands. Data last updated October 30, 2026 and is based on user searches.
This Justfly.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:05 pm -
1 stop20h 05m
Fri 11/61:10 pm -
1 stop27h 16m
Deal found 10/27![Air Canada logo]()
$471
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:32 am -
2 stops12h 28m
Fri 11/612:54 pm -
1 stop9h 53m
Deal found 10/28![American Airlines logo]()
$822
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 am -
1 stop7h 00m
Wed 11/45:45 pm -
2 stops24h 14m
Deal found 10/26![United Airlines logo]()
$942
One-way flights from St. Louis to Cayman IslandsSearch for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/297:05 am -
1 stop5h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Delta logo]()
$235
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:08 pm -
2 stops21h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![United Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:58 pm -
3 stops40h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Multiple Airlines logo]()
$401
Find flight deals from St. Louis to Cayman Islands
Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated October 30, 2026.
Round-trip from | $418 (American Airlines) |
|---|---|
One-way from | $235 (Delta) |
Popular in | February |
Cheapest in | April |
Average price | $587 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Tue 12/29
7:05 am-1:12 pm
1 stop5h 07m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$235
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Tue 12/29
5:08 pm-4:00 pm
2 stops21h 52m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$306
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Tue 12/29
5:58 pm-11:35 am
3 stops40h 37m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$401
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Wed 12/9
4:05 pm-12:10 pm
1 stop19h 05m
George Town Owen Roberts Intl
Wed 12/16
1:10 pm-3:26 pm
1 stop27h 16m
$478
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Wed 12/9
3:25 pm-12:35 pm
2 stops20h 10m
George Town Owen Roberts Intl
Wed 12/16
1:30 pm-7:25 pm
1 stop6h 55m
$514
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Wed 12/9
7:27 am-8:01 pm
2 stops11h 34m
George Town Owen Roberts Intl
Wed 12/16
12:55 pm-9:41 pm
2 stops9h 46m
$519
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Mon 2/22
5:00 am-12:55 pm
1 stop6h 55m
George Town Owen Roberts Intl
Sat 2/27
1:25 pm-11:20 pm
1 stop10h 55m
$573
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Sat 4/17
6:00 am-1:05 pm
1 stop7h 05m
George Town Owen Roberts Intl
Sat 5/1
2:30 pm-11:39 pm
1 stop9h 09m
$574
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Wed 3/17
8:50 am-3:30 pm
1 stop6h 40m
George Town Owen Roberts Intl
Tue 3/23
1:25 pm-10:58 pm
1 stop9h 33m
$576
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Mon 2/22
6:00 am-3:14 pm
2 stops8h 14m
George Town Owen Roberts Intl
Sat 2/27
11:50 am-11:46 pm
2 stops12h 56m
$576
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from St. Louis to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
STL-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to the Cayman Islands
STL-KY0
STL-GCM
What is the cheapest month to book a flight from St. Louis to Cayman Islands?
Currently, April is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $502). Flying from St. Louis to Cayman Islands in February is currently the most expensive (average of $845). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated October 30, 2026.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.4
Overall
7.9
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.4
Overall
7.9
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.4
Overall
7.9
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.4
Overall
7.9
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.4
Overall
7.9
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top regions
Alternative routes for St. Louis to Cayman Islands
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Cayman Islands by cabin class
Find flights from St. Louis to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Cayman Islands flights
Browse other St. Louis and Cayman Islands flight options. Last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 4 airlines flying from St. Louis to Cayman Islands
Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$586 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$364 | Average$575 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$422 | Average$750 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$483 | Average$655 | FlexibilityNo cancel fee | On-time63% |