$131+ Cheap flights from St. Louis (STL) to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
May 7 — May 141
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Cayman Islands
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to Cayman IslandsExplore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 7, 2026.
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 7, 2026.
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 5/51:35 pm
GCM
- STL
1 stop8h 55m
United Airlines
Deal found 4/5![United Airlines logo]()
$461
This Air Canada deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:05 pm
STL
- GCM
1 stop18h 50m
Air Canada
Sat 5/210:55 am
GCM
- STL
1 stop9h 14m
Air Canada
Deal found 4/6![Air Canada logo]()
$463
This Air Canada deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/28:55 am
STL
- GCM
1 stop26h 30m
Air Canada
Sat 8/810:40 am
GCM
- STL
1 stop9h 27m
Air Canada
Deal found 4/3![Air Canada logo]()
$465
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:24 am
STL
- GCM
1 stop7h 46m
American Airlines
Wed 5/1312:00 pm
GCM
- STL
2 stops10h 19m
American Airlines
Deal found 4/6![American Airlines logo]()
$471
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:54 pm
STL
- GCM
2 stops16h 06m
American Airlines
Fri 5/2212:33 pm
GCM
- STL
1 stop6h 27m
American Airlines
Deal found 4/3![American Airlines logo]()
$525
This Orbitz deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/288:40 am
STL
- GCM
1 stop26h 45m
Air Canada
Sat 7/410:55 am
GCM
- STL
1 stop9h 12m
Air Canada
Deal found 4/6![Air Canada logo]()
$545
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:30 pm
STL
- GCM
2 stops17h 40m
Southwest
Tue 5/261:05 pm
GCM
- STL
2 stops19h 55m
Southwest
Deal found 4/4![Southwest logo]()
$556
Best flights from St. Louis to Cayman IslandsDiscover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 7, 2026.
Discover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 7, 2026.
This Air Canada deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:05 pm
STL
- GCM
1 stop18h 50m
Air Canada
Sat 5/210:55 am
GCM
- STL
1 stop25h 11m
Air Canada
Deal found 4/4![Air Canada logo]()
$463
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 5/51:35 pm
GCM
- STL
2 stops19h 04m
United Airlines
Deal found 4/5![United Airlines logo]()
$466
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:30 am
STL
- GCM
1 stop6h 40m
Southwest
Tue 5/261:05 pm
GCM
- STL
2 stops19h 55m
Southwest
Deal found 4/4![Southwest logo]()
$525
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:00 am
STL
- GCM
1 stop6h 00m
Delta
Wed 4/291:25 pm
GCM
- STL
1 stop10h 11m
Delta
Deal found 4/5![Delta logo]()
$564
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/267:55 pm
STL
- GCM
2 stops15h 30m
American Airlines
Wed 7/2912:02 pm
GCM
- STL
2 stops11h 30m
American Airlines
Deal found 4/2![American Airlines logo]()
$584
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:30 am
STL
- GCM
1 stop7h 00m
United Airlines
Wed 4/291:35 pm
GCM
- STL
2 stops19h 04m
United Airlines
Deal found 4/5![United Airlines logo]()
$569
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
STL
- GCM
1 stop5h 54m
Delta
Wed 6/31:19 pm
GCM
- STL
1 stop8h 19m
Delta
Deal found 4/5![Delta logo]()
$579
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Wed 5/61:35 pm
GCM
- STL
1 stop8h 55m
United Airlines
Deal found 4/2![United Airlines logo]()
$581
Last-minute flights from St. Louis to Cayman IslandsDiscover last-minute flight deals from St. Louis to Cayman Islands. Data last updated April 7, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Cayman Islands. Data last updated April 7, 2026 and is based on user searches.
This Air Canada deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:05 pm
STL
- GCM
1 stop18h 50m
Air Canada
Sat 5/210:55 am
GCM
- STL
1 stop9h 14m
Air Canada
Deal found 4/6![Air Canada logo]()
$463
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:00 am
STL
- GCM
1 stop6h 00m
Delta
Wed 4/291:25 pm
GCM
- STL
1 stop10h 11m
Delta
Deal found 4/5![Delta logo]()
$564
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:30 am
STL
- GCM
1 stop7h 00m
United Airlines
Wed 4/291:35 pm
GCM
- STL
2 stops19h 04m
United Airlines
Deal found 4/5![United Airlines logo]()
$569
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 5/51:35 pm
GCM
- STL
1 stop8h 55m
United Airlines
Deal found 4/5![United Airlines logo]()
$461
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:24 am
STL
- GCM
1 stop7h 46m
American Airlines
Wed 5/1312:00 pm
GCM
- STL
2 stops10h 19m
American Airlines
Deal found 4/6![American Airlines logo]()
$471
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:54 pm
STL
- GCM
2 stops16h 06m
American Airlines
Fri 5/2212:33 pm
GCM
- STL
1 stop6h 27m
American Airlines
Deal found 4/3![American Airlines logo]()
$525
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:30 pm
STL
- GCM
2 stops17h 40m
Southwest
Tue 5/261:05 pm
GCM
- STL
2 stops19h 55m
Southwest
Deal found 4/4![Southwest logo]()
$556
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:24 am
STL
- GCM
1 stop5h 36m
American Airlines
Fri 6/55:12 pm
GCM
- STL
2 stops15h 26m
American Airlines
Deal found 4/2![American Airlines logo]()
$575
One-way flights from St. Louis to Cayman IslandsSearch for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated April 7, 2026.
Search for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated April 7, 2026.
This Air Canada deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:05 am
STL
- GCM
1 stop26h 55m
Air Canada
Deal found 4/2![Air Canada logo]()
$131
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:30 pm
STL
- GCM
2 stops16h 00m
United Airlines
Deal found 4/2![United Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/159:18 pm
STL
- GCM
3 stops44h 02m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$315
Find flight deals from St. Louis to Cayman Islands
Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated April 7, 2026.
Round-trip from | $461 (United Airlines) |
|---|---|
One-way from | $131 (Air Canada) |
Popular in | December |
Cheapest in | September |
Average price | $497 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 7, 2026.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 4/18
4:05 pm-10:55 am
1 stop18h 50m
George Town Owen Roberts Intl
Sat 5/2
10:55 am-12:06 pm
1 stop25h 11m
$463
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Thu 4/30
6:00 am-12:30 pm
1 stop6h 30m
George Town Owen Roberts Intl
Tue 5/5
1:35 pm-8:39 am
2 stops19h 04m
$466
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 5/19
5:30 am-12:10 pm
1 stop6h 40m
George Town Owen Roberts Intl
Tue 5/26
1:05 pm-9:00 am
2 stops19h 55m
$525
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 4/25
6:00 am-12:00 pm
1 stop6h 00m
George Town Owen Roberts Intl
Wed 4/29
1:25 pm-11:36 pm
1 stop10h 11m
$564
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 4/25
6:30 am-1:30 pm
1 stop7h 00m
George Town Owen Roberts Intl
Wed 4/29
1:35 pm-8:39 am
2 stops19h 04m
$569
Quickest round-trip
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Fri 5/29
6:00 am-11:54 am
1 stop5h 54m
George Town Owen Roberts Intl
Wed 6/3
1:19 pm-9:38 pm
1 stop8h 19m
$579
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Mon 5/4
6:00 am-12:30 pm
1 stop6h 30m
George Town Owen Roberts Intl
Wed 5/6
1:35 pm-10:30 pm
1 stop8h 55m
$581
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 7/26
7:55 pm-11:25 am
2 stops15h 30m
George Town Owen Roberts Intl
Wed 7/29
12:02 pm-11:32 pm
2 stops11h 30m
$584
Cheapest one-way
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Fri 5/15
7:05 am-10:00 am
1 stop26h 55m
$131
Quickest one-way
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Fri 5/15
8:30 pm-12:30 pm
2 stops16h 00m
$237
Sorted by cheapest first
Best time to book a flight from St. Louis to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
STL-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to the Cayman Islands
STL-KY0
STL-GCM
What is the cheapest month to book a flight from St. Louis to Cayman Islands?
Currently, August is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $248). Flying from St. Louis to Cayman Islands in June is currently the most expensive (average of $570). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated April 7, 2026.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Cayman Islands
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Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Cayman Islands by cabin class
Find flights from St. Louis to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Cayman Islands flights
Browse other St. Louis and Cayman Islands flight options. Last updated on April 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 4 airlines flying from St. Louis to Cayman Islands
Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$190 | Average$597 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$364 | Average$625 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$424 | Average$622 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$429 | Average$578 | FlexibilityNo cancel fee | On-time63% |