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Cayman Islands

$226+ Cheap flights from St. Louis (STL) to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
nov. 15 — nov. 221
sáb. 11/15
sáb. 11/22
1 adult, Economy
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Find flight deals from St. Louis to Cayman Islands

Cheapest flights from St. Louis to Cayman Islands
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 16, 2025.

This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/305:15 amSTL - GCM
1 stop5h 58mAmerican Airlines
dom. 12/73:14 pmGCM - STL
1 stop19h 18mAmerican Airlines
Deal found 10/16$378
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/36:00 amSTL - GCM
1 stop5h 44mDelta
sáb. 11/82:00 pmGCM - STL
1 stop9h 04mDelta
Deal found 10/16$413
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/125:17 amSTL - GCM
2 stops8h 29mAmerican Airlines
lun. 11/179:00 amGCM - STL
2 stops15h 07mAmerican Airlines
Deal found 10/16$418
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/246:00 amSTL - GCM
1 stop5h 35mDelta
jue. 10/301:05 pmGCM - STL
1 stop8h 23mDelta
Deal found 10/16$453
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/206:00 amSTL - GCM
1 stop5h 35mDelta
jue. 10/301:05 pmGCM - STL
1 stop8h 23mDelta
Deal found 10/16$468
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/186:00 amSTL - GCM
1 stop5h 35mDelta
jue. 10/301:05 pmGCM - STL
1 stop8h 23mDelta
Deal found 10/16$493
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/306:43 pmSTL - GCM
2 stops20h 47mUnited Airlines
dom. 12/75:45 pmGCM - STL
1 stop17h 15mUnited Airlines
Deal found 10/16$495
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/215:23 amSTL - GCM
1 stop5h 47mAmerican Airlines
mar. 10/2812:25 pmGCM - STL
1 stop10h 40mAmerican Airlines
Deal found 10/16$501
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/246:00 amSTL - GCM
1 stop5h 35mDelta
lun. 10/2712:55 pmGCM - STL
1 stop10h 46mDelta
Deal found 10/16$509
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/208:01 pmSTL - GCM
1 stop17h 34mAmerican Airlines
mié. 12/247:30 amGCM - STL
1 stop10h 08mAmerican Airlines
Deal found 10/15$523
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/36:43 pmSTL - GCM
2 stops20h 47mUnited Airlines
sáb. 11/85:30 pmGCM - STL
2 stops23h 16mUnited Airlines
Deal found 10/16$528
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/206:00 amSTL - GCM
1 stop5h 35mDelta
lun. 10/2712:55 pmGCM - STL
1 stop10h 46mDelta
Deal found 10/16$533

Cheap flight deals from St. Louis to Cayman Islands

Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated octubre 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$365
(Delta)

One-way from

$226
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$541
Provider with most accurate pricing for Lambert-St Louis-George Town Owen Roberts Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-George Town Owen Roberts Intl flights.
Search Deals
From Lambert-St Louis to Cayman Islands
Search Deals
One-way flight from Lambert-St Louis to Cayman Islands
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($68 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 16, 2025.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.

Fly from

St. Louis

Fly to

Cayman Islands

Route

Depart

Return

Price

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

mar. 2/3

6:00 am-12:35 pm

1 stop5h 35m

George Town Owen Roberts Intl

sáb. 2/7

2:00 pm-11:40 pm

1 stop10h 40m

$365

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

mar. 2/3

6:00 am-8:23 pm

2 stops13h 23m

George Town Owen Roberts Intl

sáb. 2/7

3:23 pm-11:26 pm

1 stop9h 03m

$370

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

dom. 11/30

5:15 am-12:13 pm

1 stop5h 58m

George Town Owen Roberts Intl

dom. 12/7

3:14 pm-9:32 am

1 stop19h 18m

$378

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

mié. 11/12

6:00 am-12:35 pm

1 stop5h 35m

George Town Owen Roberts Intl

lun. 11/17

1:50 pm-11:44 pm

1 stop10h 54m

$413

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

lun. 11/3

8:20 am-4:30 pm

1 stop7h 10m

George Town Owen Roberts Intl

sáb. 11/8

5:45 pm-10:51 am

2 stops18h 06m

$418

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

mié. 11/12

5:15 am-12:20 pm

1 stop6h 05m

George Town Owen Roberts Intl

lun. 11/17

9:00 am-11:07 pm

2 stops15h 07m

$418

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

dom. 11/30

6:43 pm-4:30 pm

2 stops20h 47m

George Town Owen Roberts Intl

dom. 12/7

5:45 pm-10:00 am

1 stop17h 15m

$495

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

dom. 3/29

6:00 am-11:35 am

1 stop5h 35m

$226

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

jue. 3/26

6:00 am-3:30 pm

1 stop9h 30m

$226

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

jue. 3/26

7:29 am-6:51 pm

2 stops11h 22m

$226

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 19 results
1
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Best time to book a flight from St. Louis to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to the Cayman Islands

What is the cheapest month to book a flight from St. Louis to Cayman Islands?

Currently, August is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $267). Flying from St. Louis to Cayman Islands in December is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated octubre 16, 2025.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,984 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,982 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,043 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Cayman Islands?

    Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to Cayman Islands from St. Louis.

  • How long is the flight from St. Louis to Cayman Islands?

    Airlines like Delta and American Airlines fly from St. Louis to Cayman Islands in about 5h 35m. The time it takes to get you to your destination can typically vary by up to 7h 48m. The distance between St. Louis and Cayman Islands is about 1448 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from St. Louis to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on St. Louis to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Cayman Islands.

  • Can I find deals for business class flights from St. Louis to Cayman Islands?

    Yes. Cheapflights offers flight deals from St. Louis to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Cayman Islands?

    Currently, August is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $267). Flying from St. Louis to Cayman Islands in December is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from St. Louis to Cayman Islands

Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$266Average$613FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$424Average$602FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$429Average$585FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$469Average$698FlexibilityNo cancel feeOn-time69%

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