$157+ Cheap flights from St. Louis (STL) to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Aug 31 — Sep 71
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Cayman Islands
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to Cayman IslandsExplore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
This Expedia deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:10 pm
STL
- GCM
2 stops47h 20m
Air Canada
Tue 10/2712:10 pm
GCM
- STL
1 stop27h 16m
Air Canada
Deal found 8/1![Air Canada logo]()
$400
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:00 am
STL
- GCM
1 stop6h 00m
American Airlines
Sat 9/1911:55 am
GCM
- STL
2 stops10h 47m
American Airlines
Deal found 7/30![American Airlines logo]()
$411
This Air Canada deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:55 am
STL
- GCM
1 stop26h 30m
Air Canada
Mon 9/1412:25 pm
GCM
- STL
1 stop25h 35m
Air Canada
Deal found 8/1![Air Canada logo]()
$415
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:00 am
STL
- GCM
1 stop6h 00m
American Airlines
Thu 9/1712:36 pm
GCM
- STL
1 stop10h 06m
American Airlines
Deal found 7/28![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:18 pm
STL
- GCM
2 stops18h 12m
American Airlines
Sat 10/103:15 pm
GCM
- STL
1 stop8h 27m
American Airlines
Deal found 7/30![American Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:07 pm
STL
- GCM
2 stops17h 03m
American Airlines
Tue 8/252:10 pm
GCM
- STL
2 stops8h 45m
American Airlines
Deal found 7/27![American Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:22 am
STL
- GCM
1 stop25h 05m
American Airlines
Sun 8/302:10 pm
GCM
- STL
1 stop8h 30m
American Airlines
Deal found 7/30![American Airlines logo]()
$433
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:54 pm
STL
- GCM
1 stop21h 33m
American Airlines
Sat 9/1211:55 am
GCM
- STL
2 stops20h 35m
American Airlines
Deal found 7/30![American Airlines logo]()
$437
This flygcity.se deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure flygcity.se is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:00 am
STL
- GCM
1 stop6h 00m
Multiple Airlines
Sat 9/1910:40 am
GCM
- STL
1 stop9h 40m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$441
Best flights from St. Louis to Cayman IslandsDiscover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
Discover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:15 am
STL
- GCM
1 stop6h 15m
American Airlines
Fri 9/2512:36 pm
GCM
- STL
1 stop10h 06m
American Airlines
Deal found 7/29![American Airlines logo]()
$419
This Flightnetwork deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:55 am
STL
- GCM
1 stop26h 30m
Air Canada
Mon 9/1412:25 pm
GCM
- STL
1 stop7h 55m
Air Canada
Deal found 7/31![Air Canada logo]()
$429
This flygcity.se deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure flygcity.se is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:34 pm
STL
- GCM
2 stops19h 53m
Multiple Airlines
Sat 9/1910:40 am
GCM
- STL
1 stop9h 40m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$441
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am
STL
- GCM
1 stop5h 40m
Delta
Fri 11/61:55 pm
GCM
- STL
1 stop10h 59m
Delta
Deal found 7/27![Delta logo]()
$499
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am
STL
- GCM
2 stops13h 00m
American Airlines
Fri 11/63:45 pm
GCM
- STL
1 stop7h 02m
American Airlines
Deal found 7/29![American Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:00 am
STL
- GCM
1 stop8h 10m
American Airlines
Tue 8/2512:30 pm
GCM
- STL
1 stop10h 25m
American Airlines
Deal found 7/27![American Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:53 am
STL
- GCM
1 stop28h 37m
American Airlines
Sat 10/103:15 pm
GCM
- STL
1 stop8h 27m
American Airlines
Deal found 8/1![American Airlines logo]()
$428
Last-minute flights from St. Louis to Cayman IslandsDiscover last-minute flight deals from St. Louis to Cayman Islands. Data last updated August 1, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Cayman Islands. Data last updated August 1, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:13 pm
STL
- GCM
2 stops16h 42m
American Airlines
Fri 8/72:10 pm
GCM
- STL
2 stops19h 22m
American Airlines
Deal found 7/27![American Airlines logo]()
$782
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:14 am
STL
- GCM
1 stop6h 16m
United Airlines
Fri 8/71:35 pm
GCM
- STL
1 stop9h 10m
United Airlines
Deal found 7/27![United Airlines logo]()
$897
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/95:00 am
STL
- GCM
1 stop6h 00m
American Airlines
Fri 8/1412:00 pm
GCM
- STL
1 stop10h 40m
American Airlines
Deal found 7/31![American Airlines logo]()
$717
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:00 am
STL
- GCM
1 stop8h 10m
American Airlines
Tue 8/2512:30 pm
GCM
- STL
1 stop10h 25m
American Airlines
Deal found 7/27![American Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:00 am
STL
- GCM
1 stop5h 39m
Delta
Tue 8/251:04 pm
GCM
- STL
1 stop10h 17m
Delta
Deal found 7/31![Delta logo]()
$623
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:22 am
STL
- GCM
1 stop25h 05m
American Airlines
Sun 8/302:10 pm
GCM
- STL
1 stop8h 30m
American Airlines
Deal found 7/30![American Airlines logo]()
$433
One-way flights from St. Louis to Cayman IslandsSearch for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
Search for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/285:00 am
STL
- GCM
1 stop13h 58m
American Airlines
Deal found 8/1![American Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:31 pm
STL
- GCM
3 stops20h 49m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$604
Find flight deals from St. Louis to Cayman Islands
Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated August 1, 2026.
Round-trip from | $411 (American Airlines) |
|---|---|
One-way from | $157 (American Airlines) |
Popular in | June |
Cheapest in | April |
Average price | $638 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 9/20
5:15 am-11:30 am
1 stop6h 15m
George Town Owen Roberts Intl
Fri 9/25
12:36 pm-10:42 pm
1 stop10h 06m
$419
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 10/31
6:00 am-7:00 pm
2 stops13h 00m
George Town Owen Roberts Intl
Fri 11/6
3:45 pm-9:47 pm
1 stop7h 02m
$424
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 8/19
5:00 am-1:10 pm
1 stop8h 10m
George Town Owen Roberts Intl
Tue 8/25
12:30 pm-10:55 pm
1 stop10h 25m
$424
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 9/26
6:53 am-11:30 am
1 stop28h 37m
George Town Owen Roberts Intl
Sat 10/10
3:15 pm-11:42 pm
1 stop8h 27m
$428
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 9/6
8:55 am-11:25 am
1 stop26h 30m
George Town Owen Roberts Intl
Mon 9/14
12:25 pm-8:20 pm
1 stop7h 55m
$429
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Thu 9/10
3:34 pm-11:27 am
2 stops19h 53m
George Town Owen Roberts Intl
Sat 9/19
10:40 am-8:20 pm
1 stop9h 40m
$441
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 10/31
6:00 am-11:40 am
1 stop5h 40m
George Town Owen Roberts Intl
Fri 11/6
1:55 pm-11:54 pm
1 stop10h 59m
$499
Cheapest one-way
Quickest one-way
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 11/28
7:24 am-7:58 pm
2 stops11h 34m
$157
Sorted by cheapest first
Best time to book a flight from St. Louis to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
STL-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to the Cayman Islands
STL-KY0
STL-GCM
What is the cheapest month to book a flight from St. Louis to Cayman Islands?
Currently, April is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $502). Flying from St. Louis to Cayman Islands in June is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated August 1, 2026.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from St. Louis to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Cayman Islands flights
Browse other St. Louis and Cayman Islands flight options. Last updated on August 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 4 airlines flying from St. Louis to Cayman Islands
Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$586 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$364 | Average$604 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$433 | Average$578 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$464 | Average$662 | FlexibilityNo cancel fee | On-time71% |