$106+ Cheap flights from St. Louis (STL) to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from St. Louis to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Cayman Islands
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Best
Last-minute
One-way
Cheapest flights from St. Louis to Cayman IslandsExplore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 4/71:35 pm
GCM
- STL
1 stop8h 53m
United Airlines
Deal found 2/1![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:00 am
STL
- GCM
2 stops13h 15m
American Airlines
Wed 3/257:45 am
GCM
- STL
2 stops11h 45m
American Airlines
Deal found 1/31![American Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:00 am
STL
- GCM
1 stop7h 25m
American Airlines
Thu 3/263:30 pm
GCM
- STL
1 stop17h 25m
American Airlines
Deal found 2/3![American Airlines logo]()
$392
This Air Canada deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:05 pm
STL
- GCM
1 stop18h 50m
Air Canada
Sat 5/212:25 pm
GCM
- STL
1 stop23h 41m
Air Canada
Deal found 2/1![Air Canada logo]()
$396
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:05 am
STL
- GCM
2 stops12h 10m
American Airlines
Mon 4/63:50 pm
GCM
- STL
1 stop17h 04m
American Airlines
Deal found 2/3![American Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:00 am
STL
- GCM
2 stops13h 15m
American Airlines
Tue 4/77:45 am
GCM
- STL
2 stops15h 14m
American Airlines
Deal found 2/2![American Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:00 am
STL
- GCM
2 stops10h 30m
United Airlines
Mon 3/301:35 pm
GCM
- STL
1 stop8h 53m
United Airlines
Deal found 1/31![United Airlines logo]()
$417
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:55 pm
STL
- GCM
2 stops16h 05m
American Airlines
Mon 4/2712:35 pm
GCM
- STL
1 stop25h 58m
American Airlines
Deal found 2/1![American Airlines logo]()
$430
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:03 pm
STL
- GCM
2 stops15h 30m
American Airlines
Sat 5/24:03 pm
GCM
- STL
1 stop16h 27m
American Airlines
Deal found 2/3![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:33 pm
STL
- GCM
1 stop19h 11m
American Airlines
Sun 3/294:38 pm
GCM
- STL
1 stop16h 17m
American Airlines
Deal found 2/2![American Airlines logo]()
$448
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:25 am
STL
- GCM
1 stop6h 20m
United Airlines
Thu 2/262:50 pm
GCM
- STL
1 stop7h 50m
United Airlines
Deal found 2/2![United Airlines logo]()
$471
Best flights from St. Louis to Cayman IslandsDiscover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/185:00 am
STL
- GCM
1 stop7h 45m
United Airlines
Wed 3/251:50 pm
GCM
- STL
1 stop7h 52m
United Airlines
Deal found 1/31![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:35 am
STL
- GCM
2 stops9h 40m
American Airlines
Tue 4/77:45 am
GCM
- STL
1 stop14h 39m
American Airlines
Deal found 2/2![American Airlines logo]()
$372
This Air Canada deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:05 pm
STL
- GCM
1 stop18h 50m
Air Canada
Sat 5/212:25 pm
GCM
- STL
1 stop23h 41m
Air Canada
Deal found 2/1![Air Canada logo]()
$396
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 4/71:35 pm
GCM
- STL
1 stop8h 53m
United Airlines
Deal found 2/1![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/257:00 am
STL
- GCM
1 stop7h 25m
American Airlines
Mon 3/303:50 pm
GCM
- STL
1 stop17h 05m
American Airlines
Deal found 1/31![American Airlines logo]()
$392
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
STL
- GCM
1 stop6h 15m
United Airlines
Mon 4/271:35 pm
GCM
- STL
1 stop8h 53m
United Airlines
Deal found 2/1![United Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/195:12 am
STL
- GCM
1 stop9h 13m
American Airlines
Tue 3/243:30 pm
GCM
- STL
1 stop7h 52m
American Airlines
Deal found 1/31![American Airlines logo]()
$392
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:05 am
STL
- GCM
2 stops12h 10m
American Airlines
Mon 4/63:50 pm
GCM
- STL
1 stop17h 04m
American Airlines
Deal found 2/3![American Airlines logo]()
$397
Last-minute flights from St. Louis to Cayman IslandsDiscover last-minute flight deals from St. Louis to Cayman Islands. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Cayman Islands. Data last updated February 3, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:25 am
STL
- GCM
1 stop6h 20m
United Airlines
Thu 2/262:50 pm
GCM
- STL
1 stop7h 50m
United Airlines
Deal found 2/2![United Airlines logo]()
$471
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:57 pm
STL
- GCM
1 stop15h 26m
American Airlines
Thu 2/2612:50 pm
GCM
- STL
2 stops9h 47m
American Airlines
Deal found 2/2![American Airlines logo]()
$487
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:00 am
STL
- GCM
2 stops13h 15m
American Airlines
Wed 3/257:45 am
GCM
- STL
2 stops11h 45m
American Airlines
Deal found 1/31![American Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:00 am
STL
- GCM
1 stop7h 25m
American Airlines
Thu 3/263:30 pm
GCM
- STL
1 stop17h 25m
American Airlines
Deal found 2/3![American Airlines logo]()
$392
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 am
STL
- GCM
1 stop9h 30m
United Airlines
Tue 3/244:45 pm
GCM
- STL
2 stops19h 42m
United Airlines
Deal found 1/31![United Airlines logo]()
$482
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:33 pm
STL
- GCM
1 stop19h 11m
American Airlines
Sun 3/294:38 pm
GCM
- STL
1 stop16h 17m
American Airlines
Deal found 2/2![American Airlines logo]()
$448
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:00 am
STL
- GCM
2 stops10h 30m
United Airlines
Mon 3/301:35 pm
GCM
- STL
1 stop8h 53m
United Airlines
Deal found 1/31![United Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 4/71:35 pm
GCM
- STL
1 stop8h 53m
United Airlines
Deal found 2/1![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:05 am
STL
- GCM
2 stops12h 10m
American Airlines
Mon 4/63:50 pm
GCM
- STL
1 stop17h 04m
American Airlines
Deal found 2/3![American Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:00 am
STL
- GCM
2 stops13h 15m
American Airlines
Tue 4/77:45 am
GCM
- STL
2 stops15h 14m
American Airlines
Deal found 2/1![American Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Wed 4/11:50 pm
GCM
- STL
1 stop9h 06m
United Airlines
Deal found 2/2![United Airlines logo]()
$477
One-way flights from St. Louis to Cayman IslandsSearch for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:00 am
STL
- GCM
1 stop5h 29m
Delta
Deal found 2/2![Delta logo]()
$106
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/239:37 am
STL
- GCM
2 stops9h 38m
American Airlines
Deal found 2/1![American Airlines logo]()
$120
This Gotogate deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:30 am
STL
- GCM
1 stop28h 00m
Air Canada
Deal found 2/2![Air Canada logo]()
$138
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:45 pm
STL
- GCM
2 stops15h 25m
Southwest
Deal found 2/2![Southwest logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:13 pm
STL
- GCM
3 stops45h 47m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$471
Find flight deals from St. Louis to Cayman Islands
Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $367 (United Airlines) |
One-way from | $106 (Delta) |
Popular in | March |
Cheapest in | September |
Average price | $708 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.
Fly from
St. Louis
Fly to
Cayman Islands
Route
Depart
Return
Price
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 3/18
5:00 am-12:45 pm
1 stop7h 45m
George Town Owen Roberts Intl
Wed 3/25
1:50 pm-9:42 pm
1 stop7h 52m
$367
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 3/31
6:00 am-12:30 pm
1 stop6h 30m
George Town Owen Roberts Intl
Tue 4/7
1:35 pm-10:28 pm
1 stop8h 53m
$367
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 3/31
9:35 am-7:15 pm
2 stops9h 40m
George Town Owen Roberts Intl
Tue 4/7
7:45 am-10:24 pm
1 stop14h 39m
$372
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Thu 4/23
6:30 am-12:45 pm
1 stop6h 15m
George Town Owen Roberts Intl
Mon 4/27
1:35 pm-10:28 pm
1 stop8h 53m
$372
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 3/25
7:00 am-2:25 pm
1 stop7h 25m
George Town Owen Roberts Intl
Mon 3/30
3:50 pm-8:55 am
1 stop17h 05m
$392
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Thu 3/19
5:12 am-2:25 pm
1 stop9h 13m
George Town Owen Roberts Intl
Tue 3/24
3:30 pm-11:22 pm
1 stop7h 52m
$392
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 4/18
4:05 pm-10:55 am
1 stop18h 50m
George Town Owen Roberts Intl
Sat 5/2
12:25 pm-12:06 pm
1 stop23h 41m
$396
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 3/31
7:05 am-7:15 pm
2 stops12h 10m
George Town Owen Roberts Intl
Mon 4/6
3:50 pm-8:54 am
1 stop17h 04m
$397
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Mon 2/23
6:00 am-12:29 pm
1 stop5h 29m
$106
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Mon 2/23
9:37 am-8:15 pm
2 stops9h 38m
$120
Showing 1-10 of 13 results
Best time to book a flight from St. Louis to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
STL-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to the Cayman Islands
STL-KY0
STL-GCM
What is the cheapest month to book a flight from St. Louis to Cayman Islands?
Currently, April is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $258). Flying from St. Louis to Cayman Islands in March is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated February 3, 2026.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
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St. Louis and Cayman Islands flights
Browse other St. Louis and Cayman Islands flight options. Last updated on February 3, 2026.
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Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 4 airlines flying from St. Louis to Cayman Islands
Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$198 | Average$605 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$360 | Average$625 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$429 | Average$585 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$446 | Average$626 | FlexibilityNo cancel fee | On-time71% |