$157+ Cheap flights from St. Louis (STL) to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Jul 31 — Aug 71
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Cayman Islands with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Cayman Islands
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Last-minute
One-way
Cheapest flights from St. Louis to Cayman IslandsExplore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2026.
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2026.
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:10 am
STL
- GCM
1 stop6h 15m
American Airlines
Tue 8/1812:00 pm
GCM
- STL
1 stop10h 40m
American Airlines
Deal found 6/26![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:00 am
STL
- GCM
1 stop8h 10m
American Airlines
Tue 8/2512:30 pm
GCM
- STL
1 stop10h 25m
American Airlines
Deal found 7/1![American Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:25 pm
STL
- GCM
2 stops18h 45m
American Airlines
Sat 8/154:00 pm
GCM
- STL
2 stops16h 24m
American Airlines
Deal found 6/27![American Airlines logo]()
$460
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:21 am
STL
- GCM
1 stop26h 06m
American Airlines
Sun 8/1612:30 pm
GCM
- STL
1 stop11h 24m
American Airlines
Deal found 6/27![American Airlines logo]()
$469
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am
STL
- GCM
1 stop5h 40m
Delta
Sat 10/3112:55 pm
GCM
- STL
1 stop6h 51m
Delta
Deal found 7/1![Delta logo]()
$471
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am
STL
- GCM
2 stops13h 00m
American Airlines
Sat 10/3112:00 pm
GCM
- STL
2 stops11h 59m
American Airlines
Deal found 7/1![American Airlines logo]()
$476
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:40 am
STL
- GCM
1 stop6h 55m
United Airlines
Sat 11/72:50 pm
GCM
- STL
1 stop7h 23m
United Airlines
Deal found 6/28![United Airlines logo]()
$491
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am
STL
- GCM
2 stops13h 00m
American Airlines
Sat 11/71:00 pm
GCM
- STL
2 stops12h 05m
American Airlines
Deal found 6/28![American Airlines logo]()
$496
Best flights from St. Louis to Cayman IslandsDiscover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 1, 2026.
Discover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 1, 2026.
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:00 am
STL
- GCM
1 stop8h 10m
American Airlines
Tue 8/2512:30 pm
GCM
- STL
1 stop10h 25m
American Airlines
Deal found 6/30![American Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am
STL
- GCM
1 stop5h 40m
Delta
Sat 10/3112:55 pm
GCM
- STL
1 stop6h 51m
Delta
Deal found 7/1![Delta logo]()
$471
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:40 am
STL
- GCM
1 stop6h 55m
United Airlines
Sat 11/72:50 pm
GCM
- STL
1 stop7h 23m
United Airlines
Deal found 6/28![United Airlines logo]()
$491
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:00 am
STL
- GCM
1 stop8h 10m
American Airlines
Fri 8/212:10 pm
GCM
- STL
1 stop8h 30m
American Airlines
Deal found 6/29![American Airlines logo]()
$471
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:45 pm
STL
- GCM
1 stop16h 55m
American Airlines
Sat 11/141:10 pm
GCM
- STL
1 stop8h 45m
American Airlines
Deal found 6/30![American Airlines logo]()
$476
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am
STL
- GCM
2 stops13h 00m
American Airlines
Sat 11/71:00 pm
GCM
- STL
2 stops12h 05m
American Airlines
Deal found 6/28![American Airlines logo]()
$496
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:03 am
STL
- GCM
2 stops11h 57m
American Airlines
Fri 11/61:00 pm
GCM
- STL
1 stop10h 32m
American Airlines
Deal found 6/30![American Airlines logo]()
$530
Last-minute flights from St. Louis to Cayman IslandsDiscover last-minute flight deals from St. Louis to Cayman Islands. Data last updated July 1, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Cayman Islands. Data last updated July 1, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:10 am
STL
- GCM
1 stop9h 53m
American Airlines
Sat 7/1812:45 pm
GCM
- STL
1 stop10h 47m
American Airlines
Deal found 6/27![American Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:07 am
STL
- GCM
1 stop6h 29m
American Airlines
Wed 7/2212:02 pm
GCM
- STL
1 stop10h 52m
American Airlines
Deal found 6/30![American Airlines logo]()
$623
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:18 am
STL
- GCM
1 stop10h 52m
American Airlines
Sun 7/265:10 pm
GCM
- STL
1 stop17h 14m
American Airlines
Deal found 6/28![American Airlines logo]()
$652
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:10 am
STL
- GCM
1 stop9h 53m
American Airlines
Sat 8/13:15 pm
GCM
- STL
1 stop17h 31m
American Airlines
Deal found 6/30![American Airlines logo]()
$579
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/258:06 pm
STL
- GCM
2 stops15h 19m
American Airlines
Wed 7/292:41 pm
GCM
- STL
1 stop9h 17m
American Airlines
Deal found 6/30![American Airlines logo]()
$584
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:05 pm
STL
- GCM
2 stops41h 25m
United Airlines
Tue 8/41:35 pm
GCM
- STL
3 stops22h 36m
United Airlines
Deal found 6/28![United Airlines logo]()
$654
One-way flights from St. Louis to Cayman IslandsSearch for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated July 1, 2026.
Search for one-way flight options from St. Louis to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated July 1, 2026.
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:53 pm
STL
- GCM
1 stop16h 07m
American Airlines
Deal found 6/27![American Airlines logo]()
$157
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:00 am
STL
- GCM
2 stops10h 00m
American Airlines
Deal found 6/27![American Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:57 pm
STL
- GCM
2 stops42h 38m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$205
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2212:40 pm
STL
- GCM
1 stop22h 45m
American Airlines
Deal found 6/26![American Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/154:57 pm
STL
- GCM
3 stops24h 23m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$304
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/65:10 am
STL
- GCM
1 stop6h 15m
American Airlines
Deal found 6/29![American Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/68:08 pm
STL
- GCM
3 stops19h 57m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$565
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:45 am
STL
- GCM
3 stops26h 40m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$1,108
Find flight deals from St. Louis to Cayman Islands
Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated July 1, 2026.
Round-trip from | $419 (American Airlines) |
|---|---|
One-way from | $157 (American Airlines) |
Popular in | June |
Cheapest in | April |
Average price | $612 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2026.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 8/19
5:00 am-1:10 pm
1 stop8h 10m
George Town Owen Roberts Intl
Tue 8/25
12:30 pm-10:55 pm
1 stop10h 25m
$424
Quickest round-trip
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 10/24
6:00 am-11:40 am
1 stop5h 40m
George Town Owen Roberts Intl
Sat 10/31
12:55 pm-7:46 pm
1 stop6h 51m
$471
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Fri 8/14
5:00 am-1:10 pm
1 stop8h 10m
George Town Owen Roberts Intl
Fri 8/21
2:10 pm-10:40 pm
1 stop8h 30m
$471
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 11/11
6:45 pm-12:40 pm
1 stop16h 55m
George Town Owen Roberts Intl
Sat 11/14
1:10 pm-8:55 pm
1 stop8h 45m
$476
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 10/31
8:40 am-3:35 pm
1 stop6h 55m
George Town Owen Roberts Intl
Sat 11/7
2:50 pm-9:13 pm
1 stop7h 23m
$491
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 10/31
6:00 am-7:00 pm
2 stops13h 00m
George Town Owen Roberts Intl
Sat 11/7
1:00 pm-12:05 am
2 stops12h 05m
$496
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 10/31
7:03 am-7:00 pm
2 stops11h 57m
George Town Owen Roberts Intl
Fri 11/6
1:00 pm-10:32 pm
1 stop10h 32m
$530
Cheapest one-way
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 12/15
9:53 am-8:15 pm
2 stops9h 22m
$157
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 7/22
4:57 pm-11:35 am
2 stops42h 38m
$205
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 7/22
12:40 pm-11:25 am
1 stop22h 45m
$259
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from St. Louis to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
STL-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to the Cayman Islands
STL-KY0
STL-GCM
What is the cheapest month to book a flight from St. Louis to Cayman Islands?
Currently, January is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $198). Flying from St. Louis to Cayman Islands in March is currently the most expensive (average of $502). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated July 1, 2026.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Boarding
8.1
Overall
7.9
Comfort
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Boarding
8.1
Overall
7.9
Comfort
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Boarding
8.1
Overall
7.9
Comfort
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Boarding
8.1
Overall
7.9
Comfort
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Boarding
8.1
Overall
7.9
Comfort
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Cayman Islands by cabin class
Find flights from St. Louis to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Cayman Islands flights
Browse other St. Louis and Cayman Islands flight options. Last updated on July 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 4 airlines flying from St. Louis to Cayman Islands
Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$346 | Average$597 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$364 | Average$604 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$429 | Average$578 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$458 | Average$660 | FlexibilityNo cancel fee | On-time71% |