$422+ Cheap flights from St. Louis (STL) to the Cayman Islands
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Sep 20 — Sep 271
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Cayman Islands
Cheapest
Best
Last-minute
Cheapest flights from St. Louis to Cayman IslandsExplore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
Explore the most affordable flight options available from St. Louis to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
2 stops13h 00m
Fri 11/68:15 am -
1 stop14h 32m
Deal found 8/18![American Airlines logo]()
$422
This Travelocity deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:05 pm -
1 stop20h 05m
Sat 11/71:10 pm -
1 stop27h 16m
Deal found 8/20![Air Canada logo]()
$433
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:05 pm -
1 stop20h 05m
Fri 11/61:10 pm -
1 stop27h 16m
Deal found 8/19![Air Canada logo]()
$442
This Air Canada deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:10 pm -
2 stops47h 15m
Sat 10/1012:25 pm -
2 stops54h 16m
Deal found 8/17![Air Canada logo]()
$445
This Orbitz deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:05 pm -
1 stop19h 05m
Sat 11/211:10 pm -
1 stop27h 16m
Deal found 8/16![Air Canada logo]()
$456
This Expedia deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:10 pm -
2 stops47h 20m
Thu 10/1512:25 pm -
1 stop7h 35m
Deal found 8/16![Air Canada logo]()
$458
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:03 am -
2 stops11h 57m
Wed 10/2112:00 pm -
2 stops11h 59m
Deal found 8/18![American Airlines logo]()
$494
Best flights from St. Louis to Cayman IslandsDiscover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
Discover carefully curated flight deals from St. Louis to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:03 am -
2 stops11h 57m
Fri 11/612:55 pm -
2 stops10h 04m
Deal found 8/19![American Airlines logo]()
$422
This Justfly.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:05 pm -
1 stop20h 05m
Fri 11/61:10 pm -
1 stop27h 16m
Deal found 8/20![Air Canada logo]()
$442
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop5h 40m
Fri 10/912:55 pm -
1 stop8h 28m
Deal found 8/18![Delta logo]()
$515
This Orbitz deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:05 pm -
1 stop19h 05m
Sat 11/211:10 pm -
1 stop27h 16m
Deal found 8/16![Air Canada logo]()
$456
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:10 am -
2 stops10h 48m
Sat 11/213:45 pm -
2 stops9h 13m
Deal found 8/19![American Airlines logo]()
$494
This Expedia deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:10 pm -
2 stops47h 20m
Thu 10/1512:25 pm -
1 stop7h 35m
Deal found 8/16![Air Canada logo]()
$458
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:00 am -
1 stop5h 40m
Mon 9/211:00 pm -
1 stop10h 42m
Deal found 8/19![Delta logo]()
$519
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop5h 40m
Sat 10/101:05 pm -
1 stop10h 49m
Deal found 8/21![Delta logo]()
$519
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:34 pm -
2 stops19h 26m
Mon 9/2112:36 pm -
2 stops11h 07m
Deal found 8/19![American Airlines logo]()
$524
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:00 am -
1 stop14h 00m
Thu 10/1512:35 pm -
1 stop6h 43m
Deal found 8/16![American Airlines logo]()
$559
Last-minute flights from St. Louis to Cayman IslandsDiscover last-minute flight deals from St. Louis to Cayman Islands. Data last updated August 21, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Cayman Islands. Data last updated August 21, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:37 pm -
2 stops18h 23m
Sat 9/1911:55 am -
2 stops21h 29m
Deal found 8/20![American Airlines logo]()
$534
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:53 pm -
2 stops41h 32m
Sat 9/191:35 pm -
1 stop20h 35m
Deal found 8/20![United Airlines logo]()
$542
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/223:34 pm -
2 stops19h 53m
Sun 9/2712:00 pm -
2 stops21h 24m
Deal found 8/19![American Airlines logo]()
$613
This Air Canada deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:10 pm -
2 stops47h 15m
Sat 10/1012:25 pm -
1 stop7h 35m
Deal found 8/17![Air Canada logo]()
$442
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop5h 40m
Sat 10/101:05 pm -
1 stop10h 49m
Deal found 8/21![Delta logo]()
$519
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:34 pm -
2 stops19h 26m
Sat 10/103:15 pm -
1 stop8h 27m
Deal found 8/18![American Airlines logo]()
$524
Find flight deals from St. Louis to Cayman Islands
Keep the following information in mind while searching for St. Louis to Cayman Islands flight deals. Data was last updated August 21, 2026.
Round-trip from | $417 (American Airlines) |
|---|---|
Popular in | October |
Cheapest in | April |
Average price | $699 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
Use the filters below to find and compare flights from St. Louis to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Sat 10/31
7:03 am-7:00 pm
2 stops11h 57m
George Town Owen Roberts Intl
Fri 11/6
12:55 pm-9:59 pm
2 stops10h 04m
$422
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Sat 10/31
4:05 pm-12:10 pm
1 stop20h 05m
George Town Owen Roberts Intl
Fri 11/6
1:10 pm-3:26 pm
1 stop27h 16m
$442
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Tue 11/17
4:05 pm-12:10 pm
1 stop19h 05m
George Town Owen Roberts Intl
Sat 11/21
1:10 pm-3:26 pm
1 stop27h 16m
$456
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Sat 10/10
12:10 pm-11:30 am
2 stops47h 20m
George Town Owen Roberts Intl
Thu 10/15
12:25 pm-8:00 pm
1 stop7h 35m
$458
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Tue 11/17
8:10 am-7:58 pm
2 stops10h 48m
George Town Owen Roberts Intl
Sat 11/21
3:45 pm-11:58 pm
2 stops9h 13m
$494
Quickest round-trip
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Fri 10/2
6:00 am-11:40 am
1 stop5h 40m
George Town Owen Roberts Intl
Fri 10/9
12:55 pm-9:23 pm
1 stop8h 28m
$515
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Thu 9/10
6:00 am-11:40 am
1 stop5h 40m
George Town Owen Roberts Intl
Mon 9/21
1:00 pm-11:42 pm
1 stop10h 42m
$519
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Sat 9/26
6:00 am-11:40 am
1 stop5h 40m
George Town Owen Roberts Intl
Sat 10/10
1:05 pm-11:54 pm
1 stop10h 49m
$519
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Thu 9/10
3:34 pm-11:00 am
2 stops19h 26m
George Town Owen Roberts Intl
Mon 9/21
12:36 pm-11:43 pm
2 stops11h 07m
$524
St. LouisGeorge Town
STL Lambert-St Louis - GCM George Town Owen Roberts Intl
STLGCM
Lambert-St Louis
Sat 10/10
5:00 am-7:00 pm
1 stop14h 00m
George Town Owen Roberts Intl
Thu 10/15
12:35 pm-7:18 pm
1 stop6h 43m
$559
Sorted by cheapest first
Best time to book a flight from St. Louis to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from St. Louis with our price prediction graph.
STL-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to the Cayman Islands
STL-KY0
STL-GCM
What is the cheapest month to book a flight from St. Louis to Cayman Islands?
Currently, April is the cheapest month in which you can book a flight from St. Louis to Cayman Islands (average of $502). Flying from St. Louis to Cayman Islands in October is currently the most expensive (average of $881). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated August 21, 2026.
Read through reviews of airlines operating flights from St. Louis to the Cayman Islands, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Cayman Islands
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Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Cayman Islands by cabin class
Find flights from St. Louis to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Cayman Islands flights
Browse other St. Louis and Cayman Islands flight options. Last updated on August 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 4 airlines flying from St. Louis to Cayman Islands
Discover the top 4 airlines that operate flights from St. Louis to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$597 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$364 | Average$604 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$468 | Average$679 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$483 | Average$627 | FlexibilityNo cancel fee | On-time63% |