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Cayman Islands

$248+ Cheap flights from Knoxville (TYS) to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GCM
Mar 20 — Mar 271
Fri 3/20
Fri 3/27
1 adult, Economy
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Cheap flight deals from Knoxville to Cayman Islands

Cheapest flights from Knoxville to Cayman Islands
Explore the most affordable flight options available from Knoxville to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 18, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/111:26 am
TYS
-
GCM
1 stop26h 31m
Multiple Airlines
Wed 4/88:00 am
GCM
-
TYS
2 stops37h 05m
Multiple Airlines
Deal found 2/16$556
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:07 pm
TYS
-
GCM
2 stops17h 55m
American Airlines
Sat 6/274:07 pm
GCM
-
TYS
2 stops17h 41m
American Airlines
Deal found 2/14$561
This Kiwi.com deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/79:03 pm
TYS
-
GCM
1 stop15h 40m
Multiple Airlines
Thu 3/121:52 pm
GCM
-
TYS
1 stop7h 32m
Multiple Airlines
Deal found 2/14$572
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:46 pm
TYS
-
GCM
1 stop21h 25m
American Airlines
Sat 6/274:07 pm
GCM
-
TYS
2 stops17h 41m
American Airlines
Deal found 2/16$574
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:00 am
TYS
-
GCM
1 stop8h 32m
American Airlines
Fri 7/312:10 pm
GCM
-
TYS
1 stop8h 49m
American Airlines
Deal found 2/17$576
This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:00 am
TYS
-
GCM
1 stop6h 45m
United Airlines
Tue 4/71:50 pm
GCM
-
TYS
1 stop7h 39m
United Airlines
Deal found 2/16$579
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:40 am
TYS
-
GCM
1 stop7h 04m
American Airlines
Tue 4/77:45 am
GCM
-
TYS
2 stops12h 36m
American Airlines
Deal found 2/16$589
This United Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/257:00 am
TYS
-
GCM
1 stop6h 45m
United Airlines
Wed 4/11:35 pm
GCM
-
TYS
1 stop9h 06m
United Airlines
Deal found 2/15$591
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:57 pm
TYS
-
GCM
2 stops17h 58m
American Airlines
Fri 4/2412:00 pm
GCM
-
TYS
2 stops19h 32m
American Airlines
Deal found 2/14$596
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/111:26 am
TYS
-
GCM
1 stop26h 31m
Multiple Airlines
Tue 4/74:25 pm
GCM
-
TYS
2 stops42h 10m
Multiple Airlines
Deal found 2/16$600
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:00 am
TYS
-
GCM
1 stop9h 13m
American Airlines
Tue 3/242:35 pm
GCM
-
TYS
1 stop8h 24m
American Airlines
Deal found 2/15$601

Find flight deals from Knoxville to Cayman Islands

Keep the following information in mind while searching for Knoxville to Cayman Islands flight deals. Data was last updated February 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$552
(Kiwi.com)

One-way from

$248
(American Airlines)

Popular in

March

Cheapest in

February

Average price

$519
Provider with most accurate pricing for Knoxville McGhee Tyson-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-George Town Owen Roberts Intl flights.
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From Knoxville McGhee Tyson to Cayman Islands
Search Deals
One-way flight from Knoxville McGhee Tyson to Cayman Islands
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Knoxville

Fly to

Cayman Islands

Route

Depart

Return

Price

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 4/1

11:26 am-12:57 pm

1 stop26h 31m

George Town Owen Roberts Intl

Wed 4/8

8:00 am-10:05 pm

2 stops37h 05m

$556

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 6/16

6:07 pm-11:02 am

2 stops17h 55m

George Town Owen Roberts Intl

Sat 6/27

4:07 pm-10:48 am

2 stops17h 41m

$561

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 7/24

6:30 pm-11:00 am

1 stop17h 30m

George Town Owen Roberts Intl

Fri 7/31

2:10 pm-10:48 am

2 stops19h 38m

$561

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 3/7

9:03 pm-12:43 pm

1 stop15h 40m

George Town Owen Roberts Intl

Thu 3/12

1:52 pm-10:24 pm

1 stop7h 32m

$572

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 3/31

7:00 am-12:45 pm

1 stop6h 45m

George Town Owen Roberts Intl

Tue 4/7

1:50 pm-10:29 pm

1 stop7h 39m

$579

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 4/1

7:00 am-12:45 pm

1 stop6h 45m

George Town Owen Roberts Intl

Wed 4/8

1:50 pm-11:03 pm

1 stop8h 13m

$579

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sun 3/29

7:00 am-12:57 pm

1 stop6h 57m

George Town Owen Roberts Intl

Wed 4/8

8:00 am-10:05 pm

2 stops37h 05m

$589

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 4/1

6:00 am-7:15 pm

1 stop14h 15m

George Town Owen Roberts Intl

Wed 4/8

2:10 pm-10:26 am

2 stops19h 16m

$589

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 6/24

6:00 am-11:02 am

1 stop6h 02m

$248

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 6/24

1:02 pm-11:35 am

3 stops23h 33m

$402

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/16

Best time to book a flight from Knoxville to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to the Cayman Islands
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated February 18, 2026.
Peruse reviews from past customers who have flown with American Airlines from Knoxville to the Cayman Islands to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,304 reviews

Comfort

7.2

Crew

8.0

Overall

7.2

Food

6.4

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,304 reviews
American Airlines
7.2
Good
11,304 reviews

Comfort

7.2

Crew

8.0

Overall

7.2

Food

6.4

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Cayman Islands?

    If you book a flight to Cayman Islands from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Cayman Islands?

    Airlines like American Airlines fly from Knoxville to Cayman Islands in about 17h 55m. The time it takes to get you to your destination can typically vary by up to . The distance between Knoxville and Cayman Islands is about 1151 mi.

  • Can I find deals for flights from Knoxville to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Knoxville to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Cayman Islands.

  • Can I find deals for business class flights from Knoxville to Cayman Islands?

    Yes. Cheapflights offers flight deals from Knoxville to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Knoxville to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Knoxville to Cayman Islands

Discover the top airline that operate flights from Knoxville to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$540Average$684FlexibilityNo cancel feeOn-time71%

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