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Cayman Islands

$489+ Cheap flights from Knoxville (TYS) to the Cayman Islands

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GCM
Mrz 17 — Mrz 241
Di 3/17
Di 3/24
1 adult, Economy
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Cheap flight deals from Knoxville to Cayman Islands

Cheapest flights from Knoxville to Cayman Islands
Explore the most affordable flight options available from Knoxville to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Februar 15, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 3/297:00 am
TYS
-
GCM
1 stop6h 57m
Multiple Airlines
So 4/51:52 pm
GCM
-
TYS
1 stop17h 18m
Multiple Airlines
Deal found 2/12$489
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 2/183:52 pm
TYS
-
GCM
1 stop21h 51m
Multiple Airlines
So 2/222:49 pm
GCM
-
TYS
2 stops32h 49m
Multiple Airlines
Deal found 2/13$501
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 3/289:36 pm
TYS
-
GCM
1 stop16h 21m
Multiple Airlines
Sa 4/41:15 pm
GCM
-
TYS
2 stops22h 52m
Multiple Airlines
Deal found 2/13$552
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 6/166:07 pm
TYS
-
GCM
2 stops17h 55m
American Airlines
Sa 6/274:07 pm
GCM
-
TYS
2 stops17h 41m
American Airlines
Deal found 2/14$561
This Kiwi.com deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 3/79:03 pm
TYS
-
GCM
1 stop15h 40m
Multiple Airlines
Do 3/121:52 pm
GCM
-
TYS
1 stop7h 32m
Multiple Airlines
Deal found 2/14$572
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/207:46 pm
TYS
-
GCM
1 stop21h 25m
American Airlines
Sa 6/274:07 pm
GCM
-
TYS
2 stops17h 41m
American Airlines
Deal found 2/11$574
This United Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 4/17:00 am
TYS
-
GCM
1 stop6h 45m
United Airlines
Mi 4/81:50 pm
GCM
-
TYS
1 stop8h 13m
United Airlines
Deal found 2/15$579
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 4/17:40 am
TYS
-
GCM
2 stops12h 35m
American Airlines
Mi 4/812:00 pm
GCM
-
TYS
2 stops10h 56m
American Airlines
Deal found 2/15$589
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 4/175:57 pm
TYS
-
GCM
2 stops17h 58m
American Airlines
Fr 4/2412:00 pm
GCM
-
TYS
2 stops19h 32m
American Airlines
Deal found 2/14$596
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 7/246:00 am
TYS
-
GCM
1 stop6h 00m
American Airlines
Fr 7/312:10 pm
GCM
-
TYS
1 stop8h 49m
American Airlines
Deal found 2/14$609

Find flight deals from Knoxville to Cayman Islands

Keep the following information in mind while searching for Knoxville to Cayman Islands flight deals. Data was last updated Februar 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$489
(Kiwi.com)

Popular in

March

Cheapest in

February

Average price

$519
Provider with most accurate pricing for Knoxville McGhee Tyson-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-George Town Owen Roberts Intl flights.
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From Knoxville McGhee Tyson to Cayman Islands
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Februar 15, 2026.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Knoxville

Fly to

Cayman Islands

Route

Depart

Return

Price

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

So 3/29

7:00 am-12:57 pm

1 stop6h 57m

George Town Owen Roberts Intl

So 4/5

1:52 pm-8:10 am

1 stop17h 18m

$489

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mi 2/18

3:52 pm-1:43 pm

1 stop21h 51m

George Town Owen Roberts Intl

So 2/22

2:49 pm-11:38 pm

2 stops32h 49m

$501

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sa 3/28

9:36 pm-12:57 pm

1 stop16h 21m

George Town Owen Roberts Intl

Sa 4/4

1:15 pm-1:07 pm

2 stops22h 52m

$552

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sa 3/7

9:03 pm-12:43 pm

1 stop15h 40m

George Town Owen Roberts Intl

Do 3/12

1:52 pm-10:24 pm

1 stop7h 32m

$572

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mi 4/1

7:00 am-12:45 pm

1 stop6h 45m

George Town Owen Roberts Intl

Mi 4/8

1:50 pm-11:03 pm

1 stop8h 13m

$579

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mi 4/1

6:00 am-7:15 pm

1 stop14h 15m

George Town Owen Roberts Intl

Mi 4/8

2:10 pm-10:26 am

2 stops19h 16m

$589

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fr 4/17

5:00 am-11:33 am

1 stop7h 33m

George Town Owen Roberts Intl

Fr 4/24

2:10 pm-11:15 am

2 stops20h 05m

$596

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sa 3/28

2:54 pm-10:40 am

1 stop20h 46m

George Town Owen Roberts Intl

Sa 4/4

7:45 am-11:59 pm

1 stop15h 14m

$617

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sa 3/28

5:40 am-9:45 am

1 stop5h 05m

George Town Owen Roberts Intl

Sa 4/4

2:30 pm-11:57 pm

1 stop8h 27m

$651

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/12

Best time to book a flight from Knoxville to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to the Cayman Islands
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated Februar 15, 2026.
Peruse reviews from past customers who have flown with American Airlines from Knoxville to the Cayman Islands to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,294 reviews

Entertainment

6.9

Comfort

7.2

Food

6.4

Overall

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,294 reviews
American Airlines
7.2
Good
11,294 reviews

Entertainment

6.9

Comfort

7.2

Food

6.4

Overall

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Cayman Islands?

    If you book a flight to Cayman Islands from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • Can I find deals for flights from Knoxville to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Knoxville to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Cayman Islands.

  • Can I find deals for business class flights from Knoxville to Cayman Islands?

    Yes. Cheapflights offers flight deals from Knoxville to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Knoxville to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Knoxville to Cayman Islands

Discover the top airline that operate flights from Knoxville to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Februar 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$540Average$684FlexibilityNo cancel feeOn-time71%

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