HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Cayman Islands

$750+ Cheap flights from Knoxville (TYS) to the Cayman Islands

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GCM
Dec 2 — Dec 91
Tue 12/2
Tue 12/9
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Cayman Islands with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Knoxville to Cayman Islands

Cheapest flights from Knoxville to Cayman Islands
Explore the most affordable flight options available from Knoxville to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2025.

This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/47:00 amTYS - GCM
1 stop9h 30mUnited Airlines
Sat 11/82:50 pmGCM - TYS
1 stop8h 05mUnited Airlines
Deal found 11/1$750
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:06 amTYS - GCM
2 stops8h 08mAmerican Airlines
Sat 11/81:20 pmGCM - TYS
2 stops10h 31mAmerican Airlines
Deal found 11/1$755
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/218:59 amTYS - GCM
1 stop5h 15mAmerican Airlines
Wed 11/263:10 pmGCM - TYS
1 stop7h 44mAmerican Airlines
Deal found 11/2$790
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/275:40 pmTYS - GCM
1 stop18h 17mAmerican Airlines
Sat 1/37:30 amGCM - TYS
1 stop10h 53mAmerican Airlines
Deal found 11/2$1,159
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:44 amTYS - GCM
1 stop7h 00mDelta
Sat 11/82:00 pmGCM - TYS
1 stop9h 22mDelta
Deal found 11/1$1,163

Cheap flight deals from Knoxville to Cayman Islands

Keep the following information in mind while searching for Knoxville to Cayman Islands flight deals. Data was last updated November 2, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$563
(American Airlines)

Popular in

March

Cheapest in

January

Average price

$684
Provider with most accurate pricing for Knoxville McGhee Tyson-George Town Owen Roberts Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-George Town Owen Roberts Intl flights.
Search Deals
From Knoxville McGhee Tyson to Cayman Islands
Search Deals
High demand for flights, 2% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Knoxville

Fly to

Cayman Islands

Route

Depart

Return

Price

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 11/21

8:59 am-2:14 pm

1 stop5h 15m

George Town Owen Roberts Intl

Wed 11/26

3:10 pm-10:54 pm

1 stop7h 44m

$790

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 12/27

5:40 pm-11:57 am

1 stop18h 17m

George Town Owen Roberts Intl

Sat 1/3

7:30 am-6:23 pm

1 stop10h 53m

$1,159

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Best time to book a flight from Knoxville to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to the Cayman Islands
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated November 2, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to the Cayman Islands to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,001 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Overall

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,001 reviews
Delta
7.9
Good
8,001 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Overall

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,034 reviews
Delta
7.9
Good
8,001 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Overall

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Cayman Islands?

    If you book a flight to Cayman Islands from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Cayman Islands?

    Airlines like American Airlines fly from Knoxville to Cayman Islands in about 5h 15m. The time it takes to get you to your destination can typically vary by up to . The distance between Knoxville and Cayman Islands is about 1151 mi.

  • Can I find deals for flights from Knoxville to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Knoxville to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Cayman Islands.

  • Can I find deals for business class flights from Knoxville to Cayman Islands?

    Yes. Cheapflights offers flight deals from Knoxville to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Luis Munoz Marin Intl flights
Memphis to Luis Munoz Marin Intl flights
Nashville to Punta Cana flights
Nashville to Saint Thomas Island flights
Nashville to Oranjestad flights
Nashville to Montego Bay flights
Nashville to Nassau flights
Memphis to Montego Bay flights
Knoxville to Luis Munoz Marin Intl flights
Nashville to Castries flights
Memphis to Punta Cana flights
Nashville to Willemstad flights
Nashville to Providenciales flights
Knoxville to Montego Bay flights
Knoxville to Oranjestad flights
Nashville to Santo Domingo flights
Memphis to Oranjestad flights
Memphis to Saint Thomas Island flights
Chattanooga to Luis Munoz Marin Intl flights
Knoxville to Providenciales flights
Knoxville to Saint Thomas Island flights
Blountville to Luis Munoz Marin Intl flights
Chattanooga to Montego Bay flights
Nashville to Kingston flights
Knoxville to Castries flights
Nashville to Bridgetown flights
Nashville to Road Town flights
Blountville to Montego Bay flights
Nashville to George Town flights
Memphis to Simpson Bay flights
Nashville to Simpson Bay flights
Knoxville to Punta Cana flights
Memphis to Nassau flights
Chattanooga to Saint Thomas Island flights
Nashville to St. George's flights
Memphis to Santo Domingo flights
Memphis to Providenciales flights
Nashville to Havana flights
Nashville to Port of Spain flights
Nashville to Gregory Town flights
Memphis to Bridgetown flights
Chattanooga to Oranjestad flights
Nashville to St. John's flights
Chattanooga to Christiansted flights
Chattanooga to Nassau flights
Knoxville to George Town flights
Nashville to Christiansted flights
Memphis to Kingston flights
Nashville to Puerto Plata flights

Top 2 airlines flying from Knoxville to Cayman Islands

Discover the top 2 airlines that operate flights from Knoxville to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$469Average$529FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$508Average$684FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.