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Cayman Islands

$506+ Cheap flights from Knoxville (TYS) to the Cayman Islands

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GCM
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Knoxville to Cayman Islands

Cheapest flights from Knoxville to Cayman Islands
Explore the most affordable flight options available from Knoxville to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/275:57 pm
TYS
-
GCM
2 stops18h 03m
American Airlines
Fri 5/12:10 pm
GCM
-
TYS
2 stops17h 22m
American Airlines
Deal found 1/27$506
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:00 am
TYS
-
GCM
1 stop6h 00m
American Airlines
Sat 5/24:03 pm
GCM
-
TYS
1 stop15h 29m
American Airlines
Deal found 1/27$526
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:00 am
TYS
-
GCM
1 stop8h 10m
American Airlines
Sat 7/2512:00 pm
GCM
-
TYS
1 stop10h 59m
American Airlines
Deal found 1/27$551
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/235:00 am
TYS
-
GCM
1 stop9h 13m
American Airlines
Fri 3/277:45 am
GCM
-
TYS
1 stop15h 14m
American Airlines
Deal found 1/27$556
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:38 pm
TYS
-
GCM
2 stops17h 22m
American Airlines
Mon 5/2512:00 pm
GCM
-
TYS
2 stops19h 35m
American Airlines
Deal found 1/27$566
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:00 pm
TYS
-
GCM
1 stop18h 40m
American Airlines
Sat 4/47:45 am
GCM
-
TYS
1 stop15h 14m
American Airlines
Deal found 1/26$588
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:21 pm
TYS
-
GCM
1 stop18h 59m
Multiple Airlines
Fri 3/205:05 pm
GCM
-
TYS
2 stops41h 27m
Multiple Airlines
Deal found 1/27$594

Find flight deals from Knoxville to Cayman Islands

Keep the following information in mind while searching for Knoxville to Cayman Islands flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$506
(American Airlines)

Popular in

June

Cheapest in

February

Average price

$540
Provider with most accurate pricing for Knoxville McGhee Tyson-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-George Town Owen Roberts Intl flights.
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From Knoxville McGhee Tyson to Cayman Islands
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($80 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Knoxville

Fly to

Cayman Islands

Route

Depart

Return

Price

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mon 4/27

5:57 pm-11:00 am

2 stops18h 03m

George Town Owen Roberts Intl

Fri 5/1

2:10 pm-8:32 am

2 stops17h 22m

$506

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 4/29

6:00 am-1:11 pm

1 stop8h 11m

George Town Owen Roberts Intl

Sat 5/2

2:10 pm-8:32 am

2 stops17h 22m

$531

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mon 4/27

5:57 pm-11:00 am

2 stops18h 03m

George Town Owen Roberts Intl

Sat 5/2

12:40 pm-9:57 pm

1 stop8h 17m

$531

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 7/17

6:00 am-1:10 pm

1 stop8h 10m

George Town Owen Roberts Intl

Sat 7/25

12:00 pm-11:59 pm

1 stop10h 59m

$551

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 5/20

6:38 pm-11:20 am

2 stops17h 42m

George Town Owen Roberts Intl

Mon 5/25

2:40 pm-11:45 pm

1 stop8h 05m

$556

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 3/13

6:21 pm-12:20 pm

1 stop18h 59m

George Town Owen Roberts Intl

Fri 3/20

5:05 pm-11:32 am

2 stops41h 27m

$594

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 3/28

2:54 pm-10:40 am

1 stop20h 46m

George Town Owen Roberts Intl

Sat 4/4

7:45 am-11:59 pm

1 stop15h 14m

$603

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mon 4/27

7:05 am-12:30 pm

1 stop6h 25m

George Town Owen Roberts Intl

Fri 5/1

1:35 pm-6:11 pm

1 stop27h 36m

$623

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Best time to book a flight from Knoxville to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to the Cayman Islands
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated January 29, 2026.
Peruse reviews from past customers who have flown with American Airlines from Knoxville to the Cayman Islands to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,206 reviews

Boarding

7.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Overall

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,206 reviews
American Airlines
7.2
Good
11,206 reviews

Boarding

7.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Overall

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Cayman Islands?

    If you book a flight to Cayman Islands from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Cayman Islands?

    Airlines like American Airlines fly from Knoxville to Cayman Islands in about 18h 03m. The time it takes to get you to your destination can typically vary by up to . The distance between Knoxville and Cayman Islands is about 1151 mi.

  • Can I find deals for flights from Knoxville to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Knoxville to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Cayman Islands.

  • Can I find deals for business class flights from Knoxville to Cayman Islands?

    Yes. Cheapflights offers flight deals from Knoxville to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Knoxville to Cayman Islands

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Top airline flying from Knoxville to Cayman Islands

Discover the top airline that operate flights from Knoxville to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$540Average$684FlexibilityNo cancel feeOn-time71%

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