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Cayman Islands

$255+ Cheap flights from Knoxville (TYS) to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GCM
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Knoxville to Cayman Islands

Keep the following information in mind while searching for Knoxville to Cayman Islands flight deals. Data was last updated September 17, 2025.

Round-trip from

$505
(American Airlines)

One-way from

$255
(Kiwi.com)

Popular in

March

Cheapest in

January

Average price

$634
From Knoxville McGhee Tyson to Cayman Islands
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One-way flight from Knoxville McGhee Tyson to Cayman Islands
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High demand for flights, 0% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Cayman Islands

Cheapest flights from Knoxville to Cayman Islands
Explore the most affordable flight options available from Knoxville to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:58 amTYS - GCM
2 stops26h 27mMultiple Airlines
Thu 11/61:30 pmGCM - TYS
2 stops32h 56mMultiple Airlines
Deal found 9/14$526
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:15 amTYS - GCM
1 stop7h 55mAmerican Airlines
Thu 11/63:10 pmGCM - TYS
1 stop7h 44mAmerican Airlines
Deal found 9/14$558
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/112:52 pmTYS - GCM
1 stop21h 33mAmerican Airlines
Sat 10/183:15 pmGCM - TYS
2 stops17h 17mAmerican Airlines
Deal found 9/16$621
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:53 pmTYS - GCM
1 stop19h 57mAmerican Airlines
Sat 1/37:30 amGCM - TYS
1 stop10h 53mAmerican Airlines
Deal found 9/15$1,034
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:15 amTYS - GCM
1 stop6h 20mDelta
Sat 10/1812:55 pmGCM - TYS
1 stop9h 12mDelta
Deal found 9/16$1,113

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Knoxville

Fly to

Cayman Islands

Route

Depart

Return

Price

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 1/6

6:58 am-12:00 pm

1 stop5h 02m

George Town Owen Roberts Intl

Mon 1/12

2:00 pm-10:08 pm

1 stop8h 08m

$505

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 10/30

9:58 am-11:25 am

2 stops26h 27m

George Town Owen Roberts Intl

Thu 11/6

1:30 pm-10:26 pm

2 stops32h 56m

$526

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 3/10

7:07 am-11:35 am

1 stop5h 28m

George Town Owen Roberts Intl

Wed 3/11

1:00 pm-9:43 pm

1 stop7h 43m

$550

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 10/30

6:15 am-1:10 pm

1 stop7h 55m

George Town Owen Roberts Intl

Thu 11/6

3:10 pm-10:54 pm

1 stop7h 44m

$558

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 10/11

2:52 pm-11:25 am

1 stop21h 33m

George Town Owen Roberts Intl

Sat 10/18

3:15 pm-9:32 am

2 stops17h 17m

$621

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 10/10

7:02 pm-11:35 am

3 stops41h 33m

$255

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 10/10

5:44 am-11:35 am

1 stop6h 51m

$301

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Best time to book a flight from Knoxville to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to the Cayman Islands
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated September 17, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to the Cayman Islands to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Cayman Islands?

    If you book a flight to Cayman Islands from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Cayman Islands?

    Airlines like American Airlines fly from Knoxville to Cayman Islands in about 5h 02m. The time it takes to get you to your destination can typically vary by up to . The distance between Knoxville and Cayman Islands is about 1151 mi.

  • Can I find deals for flights from Knoxville to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Knoxville to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Cayman Islands.

  • Can I find deals for business class flights from Knoxville to Cayman Islands?

    Yes. Cheapflights offers flight deals from Knoxville to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Cayman Islands?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Cayman Islands (average of $467). Flying from Knoxville to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Knoxville to Cayman Islands

Discover the top 2 airlines that operate flights from Knoxville to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$469Average$529FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$519Average$684FlexibilityNo cancel feeOn-time71%

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