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Cayman Islands

$562+ Cheap flights from Des Moines (DSM) to the Cayman Islands

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GCM
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Des Moines to Cayman Islands

Cheapest flights from Des Moines to Cayman Islands
Explore the most affordable flight options available from Des Moines to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:00 am
DSM
-
GCM
2 stops13h 20m
American Airlines
Tue 4/712:35 pm
GCM
-
DSM
2 stops22h 53m
American Airlines
Deal found 1/19$562
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:44 pm
DSM
-
GCM
1 stop17h 00m
American Airlines
Sat 3/145:16 pm
GCM
-
DSM
1 stop17h 18m
American Airlines
Deal found 1/20$587
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:00 am
DSM
-
GCM
1 stop6h 14m
American Airlines
Thu 3/122:15 pm
GCM
-
DSM
1 stop7h 44m
American Airlines
Deal found 1/19$590
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:04 am
DSM
-
GCM
1 stop28h 41m
United Airlines
Wed 4/151:50 pm
GCM
-
DSM
1 stop7h 37m
United Airlines
Deal found 1/20$595
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:45 pm
DSM
-
GCM
2 stops17h 45m
United Airlines
Tue 6/161:35 pm
GCM
-
DSM
1 stop8h 55m
United Airlines
Deal found 1/21$597
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:58 pm
DSM
-
GCM
2 stops15h 02m
American Airlines
Tue 7/142:40 pm
GCM
-
DSM
1 stop8h 32m
American Airlines
Deal found 1/20$602
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:01 pm
DSM
-
GCM
2 stops15h 31m
American Airlines
Thu 4/3012:35 pm
GCM
-
DSM
1 stop24h 36m
American Airlines
Deal found 1/19$603
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/81:41 pm
DSM
-
GCM
1 stop21h 39m
American Airlines
Tue 6/1612:20 pm
GCM
-
DSM
1 stop11h 31m
American Airlines
Deal found 1/21$619

Find flight deals from Des Moines to Cayman Islands

Keep the following information in mind while searching for Des Moines to Cayman Islands flight deals. Data was last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$562
(American Airlines)

Popular in

February

Cheapest in

November

Average price

$750
Provider with most accurate pricing for Des Moines-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-George Town Owen Roberts Intl flights.
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From Des Moines to Cayman Islands
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($113 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Des Moines to the Cayman Islands that are best for you.

Fly from

Des Moines

Fly to

Cayman Islands

Route

Depart

Return

Price

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Tue 3/31

6:40 am-1:44 pm

1 stop7h 04m

George Town Owen Roberts Intl

Tue 4/7

12:00 pm-11:26 am

2 stops23h 26m

$562

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 3/7

7:44 pm-1:44 pm

1 stop17h 00m

George Town Owen Roberts Intl

Sat 3/14

5:16 pm-10:34 am

1 stop17h 18m

$587

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 4/10

3:21 pm-12:30 pm

2 stops21h 09m

George Town Owen Roberts Intl

Fri 4/17

1:50 pm-9:27 pm

1 stop7h 37m

$592

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 4/9

3:21 pm-12:30 pm

2 stops21h 09m

George Town Owen Roberts Intl

Wed 4/15

1:35 pm-10:43 pm

1 stop9h 08m

$592

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Best time to book a flight from Des Moines to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to the Cayman Islands

What is the cheapest month to book a flight from Des Moines to Cayman Islands?

Currently, December is the cheapest month in which you can book a flight from Des Moines to Cayman Islands (average of $496). Flying from Des Moines to Cayman Islands in April is currently the most expensive (average of $720). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated January 21, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to the Cayman Islands. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,089 reviews

Entertainment

7.8

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,089 reviews
Delta
7.9
Good
8,089 reviews

Entertainment

7.8

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,191 reviews
Delta
7.9
Good
8,089 reviews

Entertainment

7.8

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,174 reviews
Delta
7.9
Good
8,089 reviews

Entertainment

7.8

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Cayman Islands?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Cayman Islands. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to Cayman Islands?

    A quick flight from Des Moines to Cayman Islands can take about 7h 04m. American Airlines provides one of the quickest options available for as low as $562. Des Moines and Cayman Islands are separated by a distance of 1697 mi.

  • Can I find deals for flights from Des Moines to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Des Moines to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Cayman Islands.

  • Can I find deals for business class flights from Des Moines to Cayman Islands?

    Yes. Cheapflights offers flight deals from Des Moines to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Cayman Islands?

    Currently, December is the cheapest month in which you can book a flight from Des Moines to Cayman Islands (average of $496). Flying from Des Moines to Cayman Islands in April is currently the most expensive (average of $720). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Cayman Islands

Discover the top 3 airlines that operate flights from Des Moines to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$496Average$605FlexibilityNo cancel feeOn-time69%
DeltaCheapest$565Average$750FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$575Average$617FlexibilityNo cancel feeOn-time71%

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