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Cayman Islands

$485+ Cheap flights from Des Moines (DSM) to the Cayman Islands

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GCM
ago. 16 — ago. 231
sáb. 8/16
sáb. 8/23
1 adult, Economy
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Cheap flight deals from Des Moines to Cayman Islands

Keep the following information in mind while searching for Des Moines to Cayman Islands flight deals. Data was last updated agosto 11, 2025.

Round-trip from

$485
(Southwest)

Popular in

December

Cheapest in

August

Average price

$576
From Des Moines to Cayman Islands
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($97 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($43 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Des Moines to Cayman Islands

Cheapest flights from Des Moines to Cayman Islands
Explore the most affordable flight options available from Des Moines to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 11, 2025.

This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/64:10 pmDSM - GCM
2 stops19h 25mSouthwest
jue. 11/131:30 pmGCM - DSM
2 stops11h 05mSouthwest
Deal found 8/11$485
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/610:50 amDSM - GCM
2 stops28h 15mMultiple Airlines
jue. 11/1312:40 pmGCM - DSM
1 stop21h 38mMultiple Airlines
Deal found 8/11$589
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/66:00 amDSM - GCM
1 stop13h 20mAmerican Airlines
jue. 11/133:14 pmGCM - DSM
1 stop9h 02mAmerican Airlines
Deal found 8/11$618
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/245:38 pmDSM - GCM
1 stop17h 44mAmerican Airlines
mié. 10/112:25 pmGCM - DSM
2 stops19h 44mAmerican Airlines
Deal found 8/10$626
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/276:06 pmDSM - GCM
1 stop17h 50mAmerican Airlines
sáb. 1/172:00 pmGCM - DSM
1 stop8h 57mAmerican Airlines
Deal found 8/10$760
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/234:23 pmDSM - GCM
2 stops18h 47mAmerican Airlines
sáb. 8/303:15 pmGCM - DSM
1 stop7h 15mAmerican Airlines
Deal found 8/10$840
This deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/285:49 amDSM - GCM
1 stop6h 07mAmerican Airlines
jue. 1/12:00 pmGCM - DSM
1 stop9h 06mAmerican Airlines
Deal found 8/10$993
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/297:20 pmDSM - GCM
2 stops18h 55mAmerican Airlines
lun. 9/12:10 pmGCM - DSM
2 stops20h 11mAmerican Airlines
Deal found 8/10$1,141

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 11, 2025.
Use the filters below to find and compare flights from Des Moines to the Cayman Islands that are best for you.

Fly from

Des Moines

Fly to

Cayman Islands

Route

Depart

Return

Price

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

jue. 11/6

4:10 pm-12:35 pm

2 stops19h 25m

George Town Owen Roberts Intl

jue. 11/13

1:30 pm-11:35 pm

2 stops11h 05m

$485

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

jue. 11/6

10:50 am-4:05 pm

2 stops28h 15m

George Town Owen Roberts Intl

jue. 11/13

12:40 pm-9:18 am

1 stop21h 38m

$589

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

vie. 1/2

5:49 am-12:56 pm

1 stop6h 07m

George Town Owen Roberts Intl

jue. 1/8

8:30 am-10:25 pm

1 stop14h 55m

$601

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

jue. 11/6

6:00 am-8:20 pm

1 stop13h 20m

George Town Owen Roberts Intl

jue. 11/13

3:14 pm-11:16 pm

1 stop9h 02m

$618

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

jue. 2/5

5:45 am-12:35 pm

1 stop5h 50m

George Town Owen Roberts Intl

vie. 2/13

2:00 pm-10:28 pm

1 stop9h 28m

$625

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

mié. 9/24

5:38 pm-11:22 am

1 stop17h 44m

George Town Owen Roberts Intl

mié. 10/1

12:25 pm-8:09 am

2 stops19h 44m

$626

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

jue. 2/5

5:45 am-12:35 pm

1 stop5h 50m

George Town Owen Roberts Intl

mié. 2/11

2:00 pm-9:30 am

2 stops20h 30m

$629

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

jue. 2/5

10:15 am-12:35 pm

2 stops25h 20m

George Town Owen Roberts Intl

sáb. 2/14

12:25 pm-8:53 pm

2 stops9h 28m

$630

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

jue. 2/5

5:45 am-12:35 pm

1 stop5h 50m

George Town Owen Roberts Intl

lun. 2/9

2:00 pm-10:28 pm

1 stop9h 28m

$650

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

sáb. 2/7

1:44 pm-12:00 pm

2 stops21h 16m

George Town Owen Roberts Intl

mié. 2/11

2:15 pm-10:25 pm

1 stop9h 10m

$690

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/11

Best time to book a flight from Des Moines to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to the Cayman Islands

What is the cheapest time of day to fly from DSM to KY?

Find hourly flight availability from Des Moines to Cayman Islands. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Cayman Islands as you normally would.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated agosto 11, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to the Cayman Islands. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,978 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,922 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Cayman Islands?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Cayman Islands. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • Can I find deals for flights from Des Moines to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Des Moines to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Cayman Islands.

  • Can I find deals for business class flights from Des Moines to Cayman Islands?

    Yes. Cheapflights offers flight deals from Des Moines to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Cayman Islands?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Cayman Islands (average of $467). Flying from Des Moines to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Des Moines to Cayman Islands

Discover the top 2 airlines that operate flights from Des Moines to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$457Average$605FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$555Average$655FlexibilityNo cancel feeOn-time71%

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