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Cayman Islands

$293+ Cheap flights from Des Moines (DSM) to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GCM
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Des Moines to Cayman Islands

Cheapest flights from Des Moines to Cayman Islands
Explore the most affordable flight options available from Des Moines to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/144:21 pmDSM - GCM
2 stops18h 14mMultiple Airlines
Sat 12/205:56 pmGCM - DSM
1 stop16h 00mMultiple Airlines
Deal found 12/3$521
This Delta deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:34 amDSM - GCM
1 stop6h 01mDelta
Sat 12/202:05 pmGCM - DSM
1 stop9h 26mDelta
Deal found 12/3$526
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/144:07 pmDSM - GCM
2 stops19h 17mAmerican Airlines
Sat 12/203:45 pmGCM - DSM
2 stops17h 30mAmerican Airlines
Deal found 12/3$531
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:52 pmDSM - GCM
2 stops16h 05mAmerican Airlines
Mon 1/53:45 pmGCM - DSM
2 stops20h 05mAmerican Airlines
Deal found 12/2$683
This United Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:46 pmDSM - GCM
2 stops44h 49mUnited Airlines
Sat 1/172:50 pmGCM - DSM
1 stop8h 00mUnited Airlines
Deal found 12/4$821
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:57 pmDSM - GCM
1 stop18h 38mAmerican Airlines
Sat 1/174:25 pmGCM - DSM
1 stop7h 58mAmerican Airlines
Deal found 12/2$850
This deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amDSM - GCM
1 stop9h 00mUnited Airlines
Mon 1/52:50 pmGCM - DSM
1 stop7h 50mUnited Airlines
Deal found 12/4$1,347

Find flight deals from Des Moines to Cayman Islands

Keep the following information in mind while searching for Des Moines to Cayman Islands flight deals. Data was last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$423
(Kiwi.com)

One-way from

$293
(Delta)

Popular in

December

Cheapest in

November

Average price

$947
Provider with most accurate pricing for Des Moines-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-George Town Owen Roberts Intl flights.
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From Des Moines to Cayman Islands
Search Deals
One-way flight from Des Moines to Cayman Islands
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Des Moines to the Cayman Islands that are best for you.

Fly from

Des Moines

Fly to

Cayman Islands

Route

Depart

Return

Price

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sun 1/18

5:35 am-12:40 pm

1 stop6h 05m

George Town Owen Roberts Intl

Wed 1/21

2:05 pm-10:29 pm

1 stop9h 24m

$496

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 3/11

6:00 am-7:15 pm

2 stops13h 15m

George Town Owen Roberts Intl

Wed 3/18

12:05 pm-9:51 pm

2 stops9h 46m

$501

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Mon 3/9

7:00 am-11:35 am

2 stops28h 35m

George Town Owen Roberts Intl

Tue 3/17

1:00 pm-10:22 am

2 stops21h 22m

$501

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Mon 3/9

4:25 pm-11:35 am

2 stops19h 10m

George Town Owen Roberts Intl

Thu 3/12

1:00 pm-9:35 am

2 stops20h 35m

$501

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Mon 3/9

11:02 am-11:35 am

2 stops24h 33m

George Town Owen Roberts Intl

Wed 3/11

1:00 pm-9:35 am

2 stops20h 35m

$501

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Tue 3/10

7:00 am-11:35 am

2 stops28h 35m

George Town Owen Roberts Intl

Tue 3/17

1:00 pm-10:22 am

2 stops21h 22m

$501

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sun 12/14

5:34 am-12:35 pm

1 stop6h 01m

George Town Owen Roberts Intl

Sat 12/20

2:05 pm-10:31 pm

1 stop9h 26m

$526

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/16

5:16 pm-11:00 am

1 stop16h 44m

George Town Owen Roberts Intl

Tue 1/27

2:05 pm-10:29 pm

1 stop9h 24m

$526

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 4/23

2:05 pm-10:45 am

2 stops20h 40m

George Town Owen Roberts Intl

Thu 4/30

2:50 pm-9:44 pm

1 stop6h 54m

$531

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 2/19

4:21 pm-12:29 pm

2 stops19h 08m

George Town Owen Roberts Intl

Thu 2/26

1:54 pm-10:17 am

2 stops21h 23m

$531

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 14 results
1
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Best time to book a flight from Des Moines to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to the Cayman Islands

What is the cheapest month to book a flight from Des Moines to Cayman Islands?

Currently, December is the cheapest month in which you can book a flight from Des Moines to Cayman Islands (average of $496). Flying from Des Moines to Cayman Islands in April is currently the most expensive (average of $708). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to KY?

Find hourly flight availability from Des Moines to Cayman Islands. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to Cayman Islands in the evening. If you’re flexible enough to do this you can expect to save up to 32% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated December 4, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to the Cayman Islands. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,063 reviews
Delta
7.9
Good
8,011 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,045 reviews
Delta
7.9
Good
8,011 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Cayman Islands?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Cayman Islands. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to Cayman Islands?

    A quick flight from Des Moines to Cayman Islands can take about 6h 05m. Delta provides one of the quickest options available for as low as $496. Des Moines and Cayman Islands are separated by a distance of 1697 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Des Moines to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Des Moines to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Cayman Islands.

  • Can I find deals for business class flights from Des Moines to Cayman Islands?

    Yes. Cheapflights offers flight deals from Des Moines to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Cayman Islands?

    Currently, December is the cheapest month in which you can book a flight from Des Moines to Cayman Islands (average of $496). Flying from Des Moines to Cayman Islands in April is currently the most expensive (average of $708). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Cayman Islands

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Top 3 airlines flying from Des Moines to Cayman Islands

Discover the top 3 airlines that operate flights from Des Moines to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$555Average$605FlexibilityNo cancel feeOn-time69%
DeltaCheapest$565Average$707FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$575Average$671FlexibilityNo cancel feeOn-time71%

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