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Cayman Islands

$386+ Cheap flights from Des Moines (DSM) to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GCM
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Find flight deals from Des Moines to Cayman Islands

Cheapest flights from Des Moines to Cayman Islands
Explore the most affordable flight options available from Des Moines to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/124:10 pmDSM - GCM
2 stops19h 50mSouthwest
Tue 12/161:30 pmGCM - DSM
2 stops9h 05mSouthwest
Deal found 10/15$540
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:04 pmDSM - GCM
1 stop17h 25mAmerican Airlines
Tue 12/161:25 pmGCM - DSM
1 stop11h 04mAmerican Airlines
Deal found 10/15$635
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:05 amDSM - GCM
1 stop9h 25mUnited Airlines
Sun 11/165:45 pmGCM - DSM
2 stops19h 29mUnited Airlines
Deal found 10/15$640
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:42 amDSM - GCM
2 stops8h 04mAmerican Airlines
Sun 11/163:36 pmGCM - DSM
2 stops17h 56mAmerican Airlines
Deal found 10/15$645
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:46 pmDSM - GCM
2 stops20h 14mUnited Airlines
Sat 1/105:30 pmGCM - DSM
2 stops18h 25mUnited Airlines
Deal found 10/15$665
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/306:00 amDSM - GCM
1 stop7h 46mAmerican Airlines
Sun 12/71:25 pmGCM - DSM
1 stop11h 04mAmerican Airlines
Deal found 10/16$674
This Mytrip deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/3012:51 pmDSM - GCM
2 stops27h 29mMultiple Airlines
Sun 12/72:40 pmGCM - DSM
1 stop8h 41mMultiple Airlines
Deal found 10/16$677

Cheap flight deals from Des Moines to Cayman Islands

Keep the following information in mind while searching for Des Moines to Cayman Islands flight deals. Data was last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$540
(Southwest)

One-way from

$386
(Kiwi.com)

Popular in

December

Cheapest in

November

Average price

$635
Provider with most accurate pricing for Des Moines-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-George Town Owen Roberts Intl flights.
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From Des Moines to Cayman Islands
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One-way flight from Des Moines to Cayman Islands
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Highest demand for flights based on searches. 15% potential increase in price ($136 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($60 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Des Moines to the Cayman Islands that are best for you.

Fly from

Des Moines

Fly to

Cayman Islands

Route

Depart

Return

Price

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 12/12

4:10 pm-1:00 pm

2 stops19h 50m

George Town Owen Roberts Intl

Tue 12/16

1:30 pm-9:35 pm

2 stops9h 05m

$540

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 3/11

6:56 am-6:51 pm

2 stops11h 55m

George Town Owen Roberts Intl

Wed 3/18

8:30 am-10:50 pm

2 stops14h 20m

$581

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 1/31

5:00 pm-11:49 am

1 stop17h 49m

George Town Owen Roberts Intl

Wed 2/11

8:45 am-11:29 pm

1 stop15h 44m

$588

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/2

6:46 pm-4:20 pm

2 stops20h 34m

George Town Owen Roberts Intl

Fri 1/9

2:50 pm-9:50 pm

1 stop8h 00m

$635

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 12/12

5:04 pm-11:29 am

1 stop17h 25m

George Town Owen Roberts Intl

Tue 12/16

1:25 pm-11:29 pm

1 stop11h 04m

$635

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/2

6:40 am-2:35 pm

1 stop6h 55m

George Town Owen Roberts Intl

Thu 1/8

3:40 pm-11:29 pm

1 stop8h 49m

$635

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 12/12

8:15 am-4:30 pm

1 stop7h 15m

George Town Owen Roberts Intl

Tue 12/16

5:45 pm-2:20 pm

2 stops21h 35m

$640

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 10/24

8:30 am-9:15 pm

2 stops12h 45m

$386

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 10/23

2:37 pm-9:15 pm

3 stops30h 38m

$402

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Mon 10/27

6:22 pm-11:10 am

2 stops16h 48m

$418

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 16 results
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Best time to book a flight from Des Moines to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to the Cayman Islands

What is the cheapest month to book a flight from Des Moines to Cayman Islands?

Currently, November is the cheapest month in which you can book a flight from Des Moines to Cayman Islands (average of $555). Flying from Des Moines to Cayman Islands in May is currently the most expensive (average of $679). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to KY?

Find hourly flight availability from Des Moines to Cayman Islands. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to Cayman Islands in the evening. If you’re flexible enough to do this you can expect to save up to 32% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated October 16, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to the Cayman Islands. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,982 reviews
Delta
8.0
Very good
7,984 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,043 reviews
Delta
8.0
Very good
7,984 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Cayman Islands?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Cayman Islands. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to Cayman Islands?

    A quick flight from Des Moines to Cayman Islands can take about 11h 55m. Southwest provides one of the quickest options available for as low as $581. Des Moines and Cayman Islands are separated by a distance of 1697 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Cayman Islands one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $418. United Airlines flights start at $418 while deals on Delta start at $418 one-way.

  • Can I find deals for flights from Des Moines to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Des Moines to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Cayman Islands.

  • Can I find deals for business class flights from Des Moines to Cayman Islands?

    Yes. Cheapflights offers flight deals from Des Moines to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Cayman Islands?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Cayman Islands (average of $555). Flying from Des Moines to Cayman Islands in May is currently the most expensive (average of $679). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Cayman Islands

Discover the top 3 airlines that operate flights from Des Moines to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$507Average$634FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$555Average$610FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$575Average$674FlexibilityNo cancel feeOn-time71%

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