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$125+ Cheap flights from Knoxville to Buffalo (TYS - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Aug 29 — Sep 51
Sat 8/29
Sat 9/5
1 adult, Economy
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Cheap flight deals from Knoxville to Buffalo

Cheapest flights from Knoxville to Buffalo
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.

This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:33 am
TYS
-
BUF
1 stop3h 49m
Delta
Tue 9/226:05 am
BUF
-
TYS
1 stop5h 13m
Delta
Deal found 7/28$287
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:55 pm
TYS
-
BUF
2 stops21h 34m
Multiple Airlines
Mon 8/246:54 pm
BUF
-
TYS
1 stop19h 41m
Multiple Airlines
Deal found 7/26$288
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:05 am
TYS
-
BUF
1 stop6h 15m
Southwest
Tue 8/258:55 am
BUF
-
TYS
2 stops10h 00m
Southwest
Deal found 7/26$292
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:00 pm
TYS
-
BUF
2 stops8h 55m
Southwest
Mon 9/146:00 am
BUF
-
TYS
1 stop11h 10m
Southwest
Deal found 7/27$298
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:00 pm
TYS
-
BUF
2 stops8h 55m
Southwest
Mon 9/146:00 am
BUF
-
TYS
1 stop11h 10m
Southwest
Deal found 7/27$299
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:41 pm
TYS
-
BUF
1 stop4h 18m
Delta
Sat 9/126:05 am
BUF
-
TYS
1 stop4h 39m
Delta
Deal found 7/29$300
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:54 am
TYS
-
BUF
1 stop22h 29m
Multiple Airlines
Mon 8/2411:36 am
BUF
-
TYS
2 stops22h 04m
Multiple Airlines
Deal found 7/25$302
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:55 pm
TYS
-
BUF
2 stops21h 34m
Multiple Airlines
Sun 8/239:29 pm
BUF
-
TYS
1 stop21h 36m
Multiple Airlines
Deal found 7/26$304
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:30 pm
TYS
-
BUF
1 stop8h 05m
Southwest
Tue 9/228:55 am
BUF
-
TYS
2 stops10h 05m
Southwest
Deal found 7/28$305
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:54 pm
TYS
-
BUF
2 stops22h 27m
Multiple Airlines
Tue 9/296:51 pm
BUF
-
TYS
1 stop19h 51m
Multiple Airlines
Deal found 7/27$311

Find flight deals from Knoxville to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$287
(Delta)

One-way from

$125
(Kiwi.com)

Popular in

December

Cheapest in

November

Average price

$396
Provider with most accurate pricing for Knoxville McGhee Tyson-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Buffalo flights.
Search Deals
From Knoxville McGhee Tyson to Buffalo
Search Deals
One-way flight from Knoxville McGhee Tyson to Buffalo
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($113 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 8/19

6:57 am-12:38 pm

1 stop5h 41m

Buffalo

Mon 8/24

4:49 pm-8:59 pm

1 stop4h 10m

$287
Quickest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 8/22

5:45 am-9:48 am

1 stop4h 03m

Buffalo

Sat 8/22

7:59 pm-11:59 pm

1 stop4h 00m

$302

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Mon 9/28

7:25 pm-11:52 pm

1 stop4h 27m

Buffalo

Fri 10/2

6:05 am-11:18 am

1 stop5h 13m

$318

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 9/9

8:55 am-4:03 pm

1 stop7h 08m

Buffalo

Sun 9/20

6:05 am-11:18 am

1 stop5h 13m

$327

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 11/3

7:55 am-5:35 pm

2 stops9h 40m

Buffalo

Fri 11/6

5:30 pm-9:40 pm

1 stop4h 10m

$331

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 8/15

7:00 am-2:18 pm

2 stops7h 18m

Buffalo

Sat 8/22

6:55 am-1:18 pm

1 stop6h 23m

$361

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 9/15

6:00 am-2:18 pm

2 stops8h 18m

Buffalo

Fri 9/18

5:58 pm-10:49 pm

1 stop4h 51m

$374

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 10/2

1:50 pm-11:40 pm

2 stops9h 50m

Buffalo

Tue 10/6

7:25 am-4:40 pm

1 stop9h 15m

$378

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 8/27

5:45 am-9:48 am

1 stop4h 03m

Buffalo

Sat 9/12

2:53 pm-10:49 pm

2 stops7h 56m

$393

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 8/19

12:45 pm-9:05 pm

2 stops8h 20m

Buffalo

Sun 8/23

6:20 am-3:00 pm

2 stops8h 40m

$400

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/26

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Buffalo

What is the cheapest month to book a flight from Knoxville to Buffalo?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $283). Flying from Knoxville to Buffalo in December is currently the most expensive (average of $798). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated July 30, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,227 reviews

Overall

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
6.0
Good

Sharilynn,May 2024

HOU - LGA

The free WiFi was so bad, I couldn’t even watch an inflight movie.
Southwest
8.0
Very good
4,227 reviews
Southwest
8.0
Very good
4,227 reviews

Overall

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
6.0
Good

Sharilynn,May 2024

HOU - LGA

The free WiFi was so bad, I couldn’t even watch an inflight movie.
Delta
7.8
Good
8,487 reviews
Southwest
8.0
Very good
4,227 reviews

Overall

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
6.0
Good

Sharilynn,May 2024

HOU - LGA

The free WiFi was so bad, I couldn’t even watch an inflight movie.
American Airlines
7.1
Good
11,842 reviews
Southwest
8.0
Very good
4,227 reviews

Overall

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
6.0
Good

Sharilynn,May 2024

HOU - LGA

The free WiFi was so bad, I couldn’t even watch an inflight movie.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Buffalo?

    Delta and Southwest can get you from Knoxville to Buffalo in just under 3h 49m. Your travel time can differ by up to 2h 26m. There are 567 mi between Knoxville and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Buffalo round-trip?

    Flying on Delta is currently your cheapest option to Buffalo, with prices starting at $159. Additional round-trip tickets that might be worth considering are offered by American Airlines and Southwest, with the lowest prices starting at $253 and $316, respectively. These flights start at 64% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Knoxville to Buffalo one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $125. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Knoxville to Buffalo for a low price.

  • Can I find deals for flights from Knoxville to Buffalo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Buffalo.

  • Can I find deals for business class flights from Knoxville to Buffalo?

    Yes. Cheapflights offers flight deals from Knoxville to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Buffalo?

    Currently, November is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $283). Flying from Knoxville to Buffalo in December is currently the most expensive (average of $798). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Knoxville to Buffalo

Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$159Average$300FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$393FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$316Average$397FlexibilityNo cancel feeOn-time63%

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