$144+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Best
Last-minute
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/259:30 am -
1 stop4h 45m
Thu 12/317:52 pm -
1 stop4h 23m
Deal found 11/3![United Airlines logo]()
$287
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:38 am -
1 stop4h 02m
Wed 12/307:15 am -
1 stop7h 04m
Deal found 11/1![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:50 am -
1 stop3h 52m
Thu 12/105:19 am -
1 stop5h 33m
Deal found 11/3![American Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:00 am -
2 stops8h 15m
Wed 12/307:52 pm -
1 stop4h 23m
Deal found 11/2![United Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:02 am -
2 stops25h 17m
Fri 12/112:30 pm -
1 stop19h 41m
Deal found 11/3![Multiple Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/206:38 am -
1 stop4h 02m
Wed 12/307:15 am -
1 stop7h 04m
Deal found 11/1![American Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:00 pm -
1 stop9h 25m
Thu 12/1011:20 am -
2 stops9h 30m
Deal found 11/4![Southwest logo]()
$353
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:17 pm -
1 stop4h 30m
Thu 12/317:05 am -
1 stop7h 14m
Deal found 11/2![American Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:10 pm -
1 stop8h 10m
Mon 11/236:00 am -
2 stops9h 00m
Deal found 11/1![Southwest logo]()
$376
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/31:00 pm -
2 stops9h 00m
Mon 12/1411:20 am -
2 stops8h 30m
Deal found 11/3![Southwest logo]()
$379
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/257:25 am -
1 stop4h 02m
Tue 12/296:00 am -
1 stop5h 33m
Deal found 11/2![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/259:30 am -
1 stop4h 45m
Thu 12/317:52 pm -
1 stop4h 23m
Deal found 11/3![United Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:55 am -
1 stop8h 35m
Fri 12/1112:40 pm -
2 stops7h 55m
Deal found 11/3![Southwest logo]()
$380
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2212:13 pm -
1 stop5h 06m
Tue 12/296:00 am -
1 stop5h 33m
Deal found 11/2![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
2 stops8h 20m
Mon 12/1410:30 am -
1 stop6h 30m
Deal found 11/2![United Airlines logo]()
$292
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/112:45 pm -
1 stop7h 39m
Tue 12/811:23 am -
2 stops8h 24m
Deal found 11/2![United Airlines logo]()
$292
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:00 am -
2 stops8h 15m
Wed 12/307:52 pm -
1 stop4h 23m
Deal found 11/2![United Airlines logo]()
$330
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:45 pm -
1 stop5h 25m
Mon 12/710:00 am -
1 stop4h 53m
Deal found 11/3![United Airlines logo]()
$387
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated November 4, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:10 pm -
1 stop8h 10m
Mon 11/236:00 am -
2 stops9h 00m
Deal found 11/1![Southwest logo]()
$376
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:50 am -
1 stop3h 52m
Thu 12/105:19 am -
1 stop5h 33m
Deal found 11/3![American Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:02 am -
2 stops25h 17m
Fri 12/112:30 pm -
1 stop19h 41m
Deal found 11/3![Multiple Airlines logo]()
$342
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:00 pm -
1 stop9h 25m
Thu 12/1011:20 am -
2 stops9h 30m
Deal found 11/4![Southwest logo]()
$353
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/31:00 pm -
2 stops9h 00m
Mon 12/1411:20 am -
2 stops8h 30m
Deal found 11/3![Southwest logo]()
$379
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/206:38 am -
1 stop4h 02m
Wed 12/307:15 am -
1 stop7h 04m
Deal found 11/1![American Airlines logo]()
$351
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:38 am -
1 stop4h 02m
Wed 12/307:15 am -
1 stop7h 04m
Deal found 11/1![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/259:30 am -
1 stop4h 45m
Thu 12/317:52 pm -
1 stop4h 23m
Deal found 11/3![United Airlines logo]()
$287
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:00 am -
2 stops8h 15m
Wed 12/307:52 pm -
1 stop4h 23m
Deal found 11/2![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:17 pm -
1 stop4h 30m
Thu 12/317:05 am -
1 stop7h 14m
Deal found 11/2![American Airlines logo]()
$359
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:40 am -
1 stop5h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Delta logo]()
$144
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/26:45 am -
2 stops8h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Southwest logo]()
$149
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:17 pm -
1 stop4h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$176
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/217:07 am -
1 stop4h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Delta logo]()
$194
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:07 pm -
2 stops9h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![United Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:00 am -
3 stops31h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:42 pm -
2 stops23h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$251
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:00 am -
2 stops8h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![United Airlines logo]()
$254
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/266:30 am -
1 stop4h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$256
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/16:00 am -
2 stops13h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![United Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/216:40 am -
2 stops8h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Southwest logo]()
$289
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:00 am -
2 stops9h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$290
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $287 (United Airlines) |
One-way from | $144 (Delta) |
Popular in | March |
Cheapest in | October |
Average price | $366 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Thu 12/31
4:27 pm-11:06 pm
1 stop6h 39m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$144
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 12/1
5:40 am-11:05 am
1 stop5h 25m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$144
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 3/2
6:45 am-3:00 pm
2 stops8h 15m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$149
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 1/1
7:15 am-11:42 am
1 stop4h 27m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$176
Quickest round-trip
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Sun 3/21
5:45 am-9:47 am
1 stop4h 02m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$194
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Sun 3/21
7:07 am-11:15 am
1 stop4h 08m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$194
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 12/29
6:00 am-2:15 pm
2 stops8h 15m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$254
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 1/1
6:00 am-7:05 pm
2 stops13h 05m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$263
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 12/25
7:25 am-11:27 am
1 stop4h 02m
Buffalo
Tue 12/29
6:00 am-11:33 am
1 stop5h 33m
$287
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 12/25
9:30 am-2:15 pm
1 stop4h 45m
Buffalo
Thu 12/31
7:52 pm-12:15 am
1 stop4h 23m
$287
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated November 4, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Overall
8.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Overall
8.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Overall
8.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 4, 2026.
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Knoxville and Buffalo flights
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Other flights from Knoxville
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Top 3 airlines flying from Knoxville to Buffalo
Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$232 | Average$326 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$252 | Average$396 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$286 | Average$406 | FlexibilityNo cancel fee | On-time71% |