$125+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Nov 9 — Nov 161
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Best
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:56 am -
1 stop6h 31m
Sat 10/3111:38 am -
1 stop4h 40m
Deal found 10/6![American Airlines logo]()
$239
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:45 am -
1 stop4h 09m
Sat 10/316:00 am -
2 stops9h 52m
Deal found 10/6![United Airlines logo]()
$244
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/81:00 pm -
2 stops8h 55m
Sat 1/168:40 am -
2 stops9h 00m
Deal found 10/8![Southwest logo]()
$249
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:10 am -
1 stop4h 08m
Sun 11/226:00 am -
1 stop5h 28m
Deal found 10/7![Delta logo]()
$277
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/171:56 pm -
2 stops9h 03m
Sun 11/226:00 am -
1 stop5h 30m
Deal found 10/7![United Airlines logo]()
$282
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:26 am -
1 stop3h 41m
Wed 11/113:55 pm -
1 stop5h 34m
Deal found 10/8![Delta logo]()
$359
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/171:56 pm -
2 stops9h 03m
Sun 11/226:00 am -
1 stop5h 30m
Deal found 10/7![United Airlines logo]()
$282
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:26 am -
1 stop3h 41m
Wed 11/113:55 pm -
1 stop5h 34m
Deal found 10/8![Delta logo]()
$359
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/171:00 pm -
2 stops9h 00m
Sun 11/228:05 am -
2 stops8h 45m
Deal found 10/7![Southwest logo]()
$405
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:45 am -
1 stop4h 09m
Sat 10/311:53 pm -
1 stop7h 01m
Deal found 10/7![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/288:00 am -
2 stops7h 35m
Fri 1/17:25 am -
2 stops9h 15m
Deal found 10/9![Southwest logo]()
$487
This Southwest deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/288:00 am -
2 stops7h 35m
Thu 12/317:25 am -
2 stops9h 15m
Deal found 10/9![Southwest logo]()
$507
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated October 10, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated October 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:56 am -
1 stop6h 31m
Sat 10/3111:38 am -
1 stop4h 40m
Deal found 10/6![American Airlines logo]()
$239
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:45 am -
1 stop4h 09m
Sat 10/316:00 am -
2 stops9h 52m
Deal found 10/6![United Airlines logo]()
$244
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:26 am -
1 stop3h 41m
Wed 11/113:55 pm -
1 stop5h 34m
Deal found 10/8![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:10 am -
1 stop4h 08m
Sun 11/226:00 am -
1 stop5h 28m
Deal found 10/7![Delta logo]()
$277
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/171:56 pm -
2 stops9h 03m
Sun 11/226:00 am -
1 stop5h 30m
Deal found 10/7![United Airlines logo]()
$282
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2312:40 pm -
1 stop11h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Southwest logo]()
$125
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
1 stop4h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Delta logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:37 pm -
2 stops22h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:45 am -
2 stops29h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$214
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:45 pm -
1 stop4h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Delta logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:04 pm -
3 stops46h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:05 am -
2 stops7h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Southwest logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:51 pm -
2 stops22h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Multiple Airlines logo]()
$304
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:35 am -
1 stop5h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![American Airlines logo]()
$305
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:42 am -
2 stops12h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![United Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:52 pm -
3 stops21h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$318
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $239 (American Airlines) |
One-way from | $125 (Southwest) |
Popular in | March |
Cheapest in | November |
Average price | $317 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Wed 12/23
12:40 pm-11:55 pm
1 stop11h 15m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$125
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Thu 10/15
2:37 pm-12:59 pm
2 stops22h 22m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$198
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Thu 10/22
7:45 am-12:59 pm
2 stops29h 14m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$214
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 10/20
7:04 pm-5:52 pm
3 stops46h 48m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$257
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 11/20
7:05 am-2:25 pm
2 stops7h 20m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$259
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 11/17
1:56 pm-10:59 pm
2 stops9h 03m
Buffalo
Sun 11/22
6:00 am-11:30 am
1 stop5h 30m
$282
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 10/20
8:30 am-3:10 pm
1 stop6h 40m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$305
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Wed 10/14
10:42 am-11:11 pm
2 stops12h 29m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$310
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Wed 10/28
5:45 am-9:54 am
1 stop4h 09m
Buffalo
Sat 10/31
1:53 pm-8:54 pm
1 stop7h 01m
$339
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Wed 10/14
4:14 pm-5:52 pm
3 stops25h 38m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$341
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, November is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $268). Flying from Knoxville to Buffalo in March is currently the most expensive (average of $682). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Airfare is below average for this route at the moment.
Knoxville to Buffalo flights typically cost between $286 and $396 in October.The cheapest round-trip price found within the last 5 days was $239 on American Airlines (Oct 28-Oct 31).
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated October 10, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Overall
7.9
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.4
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Comfort
8.0
Overall
7.9
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.4
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Comfort
8.0
Overall
7.9
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.4
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Comfort
8.0
Overall
7.9
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.4
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 10, 2026.
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Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on October 10, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Buffalo
Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$232 | Average$326 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$397 | FlexibilityNo cancel fee | On-time63% |