$133+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Jul 27 — Aug 31
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Last-minute
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 27, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 27, 2026.
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:10 pm
TYS
- BUF
1 stop4h 41m
American Airlines
Sat 7/257:36 pm
BUF
- TYS
1 stop4h 15m
American Airlines
Deal found 6/22![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:10 am
TYS
- BUF
1 stop6h 10m
Southwest
Wed 7/2910:25 am
BUF
- TYS
2 stops10h 55m
Southwest
Deal found 6/24![Southwest logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/310:05 pm
TYS
- BUF
1 stop21h 01m
Multiple Airlines
Fri 8/72:48 pm
BUF
- TYS
2 stops19h 38m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:20 pm
TYS
- BUF
1 stop23h 46m
Multiple Airlines
Fri 7/242:48 pm
BUF
- TYS
2 stops19h 14m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:37 pm
TYS
- BUF
1 stop5h 16m
American Airlines
Tue 8/46:01 am
BUF
- TYS
1 stop4h 37m
American Airlines
Deal found 6/24![American Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:30 am
TYS
- BUF
1 stop6h 12m
American Airlines
Mon 9/146:00 am
BUF
- TYS
1 stop7h 07m
American Airlines
Deal found 6/24![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2112:45 pm
TYS
- BUF
2 stops10h 00m
Southwest
Sat 7/252:40 pm
BUF
- TYS
1 stop6h 45m
Southwest
Deal found 6/22![Southwest logo]()
$323
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:05 am
TYS
- BUF
1 stop5h 22m
Delta
Mon 10/197:40 pm
BUF
- TYS
1 stop4h 06m
Delta
Deal found 6/23![Delta logo]()
$338
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 27, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 27, 2026.
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:10 am
TYS
- BUF
1 stop6h 10m
Southwest
Wed 7/2910:25 am
BUF
- TYS
2 stops10h 55m
Southwest
Deal found 6/24![Southwest logo]()
$284
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:45 am
TYS
- BUF
1 stop4h 06m
United Airlines
Wed 8/1210:30 am
BUF
- TYS
1 stop6h 28m
United Airlines
Deal found 6/25![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:00 pm
TYS
- BUF
1 stop6h 59m
Delta
Wed 8/126:27 am
BUF
- TYS
1 stop3h 53m
Delta
Deal found 6/23![Delta logo]()
$389
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:10 am
TYS
- BUF
2 stops8h 05m
Southwest
Mon 9/285:40 am
BUF
- TYS
2 stops7h 45m
Southwest
Deal found 6/22![Southwest logo]()
$357
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/14:00 pm
TYS
- BUF
2 stops8h 10m
Southwest
Thu 10/155:05 am
BUF
- TYS
1 stop11h 40m
Southwest
Deal found 6/24![Southwest logo]()
$369
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:00 am
TYS
- BUF
2 stops6h 46m
United Airlines
Wed 12/97:00 am
BUF
- TYS
1 stop6h 18m
United Airlines
Deal found 6/24![United Airlines logo]()
$469
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3012:35 pm
TYS
- BUF
1 stop10h 05m
Southwest
Mon 8/312:40 pm
BUF
- TYS
2 stops8h 35m
Southwest
Deal found 6/24![Southwest logo]()
$418
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:45 am
TYS
- BUF
1 stop4h 05m
United Airlines
Wed 8/1210:30 am
BUF
- TYS
2 stops10h 23m
United Airlines
Deal found 6/23![United Airlines logo]()
$514
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:10 am
TYS
- BUF
1 stop6h 10m
Southwest
Sat 7/116:00 am
BUF
- TYS
2 stops10h 40m
Southwest
Deal found 6/22![Southwest logo]()
$442
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2412:35 pm
TYS
- BUF
2 stops11h 40m
Southwest
Mon 7/275:55 pm
BUF
- TYS
1 stop4h 40m
Southwest
Deal found 6/24![Southwest logo]()
$482
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated June 27, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated June 27, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:40 pm
TYS
- BUF
2 stops22h 53m
Multiple Airlines
Sun 7/199:29 pm
BUF
- TYS
1 stop23h 46m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:20 pm
TYS
- BUF
1 stop23h 46m
Multiple Airlines
Fri 7/242:48 pm
BUF
- TYS
2 stops19h 14m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:10 pm
TYS
- BUF
1 stop4h 41m
American Airlines
Sat 7/257:36 pm
BUF
- TYS
1 stop4h 15m
American Airlines
Deal found 6/22![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2112:45 pm
TYS
- BUF
2 stops10h 00m
Southwest
Sat 7/252:40 pm
BUF
- TYS
1 stop6h 45m
Southwest
Deal found 6/22![Southwest logo]()
$323
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:10 am
TYS
- BUF
1 stop6h 10m
Southwest
Wed 7/2910:25 am
BUF
- TYS
2 stops10h 55m
Southwest
Deal found 6/24![Southwest logo]()
$284
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:37 pm
TYS
- BUF
1 stop5h 16m
American Airlines
Mon 7/275:25 pm
BUF
- TYS
1 stop4h 08m
American Airlines
Deal found 6/24![American Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:37 pm
TYS
- BUF
1 stop5h 16m
American Airlines
Tue 8/46:01 am
BUF
- TYS
1 stop4h 37m
American Airlines
Deal found 6/24![American Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3012:35 pm
TYS
- BUF
2 stops11h 40m
Southwest
Tue 8/48:05 am
BUF
- TYS
2 stops10h 50m
Southwest
Deal found 6/24![Southwest logo]()
$363
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 27, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:53 pm
TYS
- BUF
2 stops45h 36m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$133
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:20 pm
TYS
- BUF
1 stop4h 24m
United Airlines
Deal found 6/23![United Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:10 am
TYS
- BUF
2 stops8h 35m
Southwest
Deal found 6/22![Southwest logo]()
$145
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:04 pm
TYS
- BUF
1 stop4h 04m
American Airlines
Deal found 6/26![American Airlines logo]()
$146
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:40 am
TYS
- BUF
1 stop5h 28m
Delta
Deal found 6/26![Delta logo]()
$149
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
TYS
- BUF
2 stops7h 20m
Southwest
Deal found 6/26![Southwest logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:03 pm
TYS
- BUF
2 stops17h 26m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$155
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:41 pm
TYS
- BUF
1 stop4h 18m
Delta
Deal found 6/23![Delta logo]()
$160
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/11:35 pm
TYS
- BUF
2 stops9h 40m
Southwest
Deal found 6/22![Southwest logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1312:40 pm
TYS
- BUF
2 stops21h 49m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:05 pm
TYS
- BUF
2 stops36h 24m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$202
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $279 (American Airlines) |
One-way from | $133 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $397 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 27, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 7/22
8:10 am-2:20 pm
1 stop6h 10m
Buffalo
Wed 7/29
10:25 am-9:20 pm
2 stops10h 55m
$284
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 9/25
7:10 am-3:15 pm
2 stops8h 05m
Buffalo
Mon 9/28
5:40 am-1:25 pm
2 stops7h 45m
$357
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 10/1
4:00 pm-12:10 am
2 stops8h 10m
Buffalo
Thu 10/15
5:05 am-4:45 pm
1 stop11h 40m
$369
Quickest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 8/10
5:45 am-9:51 am
1 stop4h 06m
Buffalo
Wed 8/12
10:30 am-4:58 pm
1 stop6h 28m
$379
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sat 8/8
5:00 pm-11:59 pm
1 stop6h 59m
Buffalo
Wed 8/12
6:27 am-10:20 am
1 stop3h 53m
$389
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 7/30
12:35 pm-10:40 pm
1 stop10h 05m
Buffalo
Mon 8/3
12:40 pm-9:15 pm
2 stops8h 35m
$418
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 7/7
8:10 am-2:20 pm
1 stop6h 10m
Buffalo
Sat 7/11
6:00 am-4:40 pm
2 stops10h 40m
$442
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 12/8
7:00 am-1:46 pm
2 stops6h 46m
Buffalo
Wed 12/9
7:00 am-1:18 pm
1 stop6h 18m
$469
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 7/24
12:35 pm-12:15 am
2 stops11h 40m
Buffalo
Mon 7/27
5:55 pm-10:35 pm
1 stop4h 40m
$482
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sat 8/8
5:45 am-9:50 am
1 stop4h 05m
Buffalo
Wed 8/12
10:30 am-8:53 pm
2 stops10h 23m
$514
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, August is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $278). Flying from Knoxville to Buffalo in December is currently the most expensive (average of $798). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated June 27, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Overall
7.9
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Overall
7.9
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Overall
7.9
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden
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Alternative routes for Knoxville to Buffalo
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 27, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Buffalo by cabin class
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Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on June 27, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Buffalo
Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$159 | Average$300 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$253 | Average$388 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$366 | FlexibilityNo cancel fee | On-time63% |