$128+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Jul 20 — Jul 271
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Best
Last-minute
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 20, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2712:55 pm
TYS
- BUF
2 stops21h 34m
Multiple Airlines
Mon 8/316:54 pm
BUF
- TYS
1 stop19h 41m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$250
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:00 pm
TYS
- BUF
1 stop5h 54m
Delta
Wed 9/306:59 pm
BUF
- TYS
1 stop4h 51m
Delta
Deal found 6/17![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:45 pm
TYS
- BUF
2 stops8h 20m
Southwest
Tue 9/296:50 am
BUF
- TYS
1 stop6h 15m
Southwest
Deal found 6/17![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:35 pm
TYS
- BUF
2 stops9h 40m
Southwest
Sat 7/252:40 pm
BUF
- TYS
1 stop6h 45m
Southwest
Deal found 6/20![Southwest logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:19 pm
TYS
- BUF
2 stops23h 02m
Multiple Airlines
Thu 10/18:54 pm
BUF
- TYS
1 stop26h 04m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/233:53 pm
TYS
- BUF
2 stops22h 00m
Multiple Airlines
Tue 7/289:09 pm
BUF
- TYS
1 stop21h 16m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$298
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:11 pm
TYS
- BUF
1 stop5h 43m
Delta
Tue 9/296:20 am
BUF
- TYS
1 stop3h 57m
Delta
Deal found 6/17![Delta logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/214:18 pm
TYS
- BUF
1 stop25h 16m
Multiple Airlines
Wed 9/301:16 pm
BUF
- TYS
2 stops18h 22m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:19 pm
TYS
- BUF
2 stops23h 02m
Multiple Airlines
Thu 10/18:54 pm
BUF
- TYS
1 stop26h 04m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/14:00 pm
TYS
- BUF
2 stops8h 10m
Southwest
Wed 10/77:30 am
BUF
- TYS
2 stops9h 15m
Southwest
Deal found 6/20![Southwest logo]()
$309
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 20, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 20, 2026.
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:10 am
TYS
- BUF
1 stop6h 10m
Southwest
Tue 7/144:25 pm
BUF
- TYS
1 stop4h 55m
Southwest
Deal found 6/18![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2712:40 pm
TYS
- BUF
2 stops9h 10m
Southwest
Mon 8/319:40 am
BUF
- TYS
2 stops7h 30m
Southwest
Deal found 6/17![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:25 am
TYS
- BUF
2 stops12h 25m
Southwest
Sun 8/1612:55 pm
BUF
- TYS
1 stop7h 50m
Southwest
Deal found 6/20![Southwest logo]()
$393
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:10 am
TYS
- BUF
2 stops8h 35m
Southwest
Sat 7/112:40 pm
BUF
- TYS
1 stop6h 45m
Southwest
Deal found 6/19![Southwest logo]()
$422
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/712:45 pm
TYS
- BUF
2 stops10h 00m
Southwest
Fri 7/1012:40 pm
BUF
- TYS
2 stops8h 35m
Southwest
Deal found 6/17![Southwest logo]()
$427
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:30 am
TYS
- BUF
1 stop6h 45m
Southwest
Fri 7/1012:40 pm
BUF
- TYS
2 stops8h 35m
Southwest
Deal found 6/18![Southwest logo]()
$432
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:35 pm
TYS
- BUF
1 stop10h 05m
Southwest
Sun 7/126:10 am
BUF
- TYS
2 stops9h 35m
Southwest
Deal found 6/17![Southwest logo]()
$438
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:30 am
TYS
- BUF
1 stop4h 35m
Southwest
Mon 7/136:05 am
BUF
- TYS
2 stops7h 40m
Southwest
Deal found 6/16![Southwest logo]()
$442
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated June 20, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated June 20, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/612:40 pm
TYS
- BUF
2 stops21h 49m
Multiple Airlines
Fri 7/107:57 pm
BUF
- TYS
1 stop14h 00m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:35 pm
TYS
- BUF
2 stops9h 40m
Southwest
Sat 7/252:40 pm
BUF
- TYS
1 stop6h 45m
Southwest
Deal found 6/20![Southwest logo]()
$293
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1811:16 am
TYS
- BUF
1 stop5h 04m
American Airlines
Sat 7/257:36 pm
BUF
- TYS
1 stop4h 15m
American Airlines
Deal found 6/20![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:17 pm
TYS
- BUF
1 stop4h 42m
American Airlines
Mon 7/277:35 pm
BUF
- TYS
1 stop4h 16m
American Airlines
Deal found 6/18![American Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:10 am
TYS
- BUF
1 stop4h 00m
Southwest
Mon 7/276:05 am
BUF
- TYS
2 stops7h 40m
Southwest
Deal found 6/18![Southwest logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/233:53 pm
TYS
- BUF
2 stops22h 00m
Multiple Airlines
Tue 7/289:09 pm
BUF
- TYS
1 stop21h 16m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2312:35 pm
TYS
- BUF
2 stops11h 40m
Southwest
Tue 7/2811:00 am
BUF
- TYS
2 stops9h 25m
Southwest
Deal found 6/18![Southwest logo]()
$338
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:00 am
TYS
- BUF
1 stop4h 16m
American Airlines
Mon 7/275:25 pm
BUF
- TYS
1 stop4h 08m
American Airlines
Deal found 6/18![American Airlines logo]()
$357
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 20, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:50 pm
TYS
- BUF
2 stops21h 50m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3112:40 pm
TYS
- BUF
2 stops22h 53m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$130
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:41 pm
TYS
- BUF
1 stop4h 18m
Delta
Deal found 6/16![Delta logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:00 am
TYS
- BUF
1 stop15h 07m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:40 pm
TYS
- BUF
2 stops41h 13m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$182
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/251:35 pm
TYS
- BUF
2 stops9h 40m
Southwest
Deal found 6/16![Southwest logo]()
$194
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:00 am
TYS
- BUF
1 stop7h 13m
United Airlines
Deal found 6/16![United Airlines logo]()
$199
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $250 (Kiwi.com) |
One-way from | $128 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $397 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 7/7
8:10 am-2:20 pm
1 stop6h 10m
Buffalo
Tue 7/14
4:25 pm-9:20 pm
1 stop4h 55m
$358
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 8/27
12:40 pm-9:50 pm
2 stops9h 10m
Buffalo
Mon 8/31
9:40 am-5:10 pm
2 stops7h 30m
$358
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 8/14
8:25 am-8:50 pm
2 stops12h 25m
Buffalo
Sun 8/16
12:55 pm-8:45 pm
1 stop7h 50m
$393
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 7/8
7:10 am-3:45 pm
2 stops8h 35m
Buffalo
Sat 7/11
2:40 pm-9:25 pm
1 stop6h 45m
$422
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 7/7
12:45 pm-10:45 pm
2 stops10h 00m
Buffalo
Fri 7/10
12:40 pm-9:15 pm
2 stops8h 35m
$427
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 7/6
7:30 am-2:15 pm
1 stop6h 45m
Buffalo
Fri 7/10
12:40 pm-9:15 pm
2 stops8h 35m
$432
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 7/10
12:35 pm-10:40 pm
1 stop10h 05m
Buffalo
Sun 7/12
6:10 am-3:45 pm
2 stops9h 35m
$438
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 7/6
7:30 am-12:05 pm
1 stop4h 35m
Buffalo
Mon 7/13
6:05 am-1:45 pm
2 stops7h 40m
$442
Cheapest one-way
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 7/31
12:40 pm-11:33 am
2 stops22h 53m
$130
Quickest one-way
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 8/17
7:41 pm-11:59 pm
1 stop4h 18m
$168
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, August is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $253). Flying from Knoxville to Buffalo in December is currently the most expensive (average of $798). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated June 20, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Comfort
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Overall
7.8
Comfort
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Overall
7.8
Comfort
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 20, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Knoxville to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on June 20, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Buffalo
Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$159 | Average$300 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$253 | Average$388 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$366 | FlexibilityNo cancel fee | On-time63% |