$103+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Jun 15 — Jun 221
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 16, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2410:05 pm
TYS
- BUF
1 stop23h 09m
Multiple Airlines
Thu 7/3011:35 am
BUF
- TYS
2 stops29h 07m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/259:22 am
TYS
- BUF
2 stops25h 17m
Multiple Airlines
Thu 7/309:02 pm
BUF
- TYS
1 stop26h 31m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:25 pm
TYS
- BUF
1 stop6h 34m
Delta
Wed 6/176:29 am
BUF
- TYS
1 stop3h 58m
Delta
Deal found 5/13![Delta logo]()
$323
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:12 am
TYS
- BUF
1 stop4h 07m
American Airlines
Tue 6/167:32 pm
BUF
- TYS
1 stop4h 15m
American Airlines
Deal found 5/12![American Airlines logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/112:55 pm
TYS
- BUF
2 stops21h 46m
Multiple Airlines
Thu 6/48:49 pm
BUF
- TYS
1 stop26h 50m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:25 am
TYS
- BUF
1 stop4h 20m
Southwest
Tue 10/67:30 am
BUF
- TYS
2 stops9h 15m
Southwest
Deal found 5/14![Southwest logo]()
$337
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/37:41 pm
TYS
- BUF
1 stop4h 18m
Delta
Mon 8/107:19 pm
BUF
- TYS
1 stop4h 33m
Delta
Deal found 5/14![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:10 am
TYS
- BUF
1 stop4h 00m
Southwest
Mon 7/135:55 pm
BUF
- TYS
1 stop4h 35m
Southwest
Deal found 5/15![Southwest logo]()
$342
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1712:45 pm
TYS
- BUF
2 stops8h 40m
Southwest
Fri 6/195:55 pm
BUF
- TYS
1 stop4h 35m
Southwest
Deal found 5/14![Southwest logo]()
$347
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:12 am
TYS
- BUF
1 stop4h 07m
American Airlines
Mon 6/155:00 am
BUF
- TYS
1 stop5h 48m
American Airlines
Deal found 5/12![American Airlines logo]()
$348
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 16, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 16, 2026.
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:00 am
TYS
- BUF
1 stop6h 20m
Southwest
Fri 9/1812:30 pm
BUF
- TYS
1 stop6h 05m
Southwest
Deal found 5/15![Southwest logo]()
$342
This Delta deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:47 am
TYS
- BUF
1 stop6h 40m
Delta
Mon 10/197:40 pm
BUF
- TYS
1 stop4h 06m
Delta
Deal found 5/16![Delta logo]()
$348
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:00 am
TYS
- BUF
1 stop4h 16m
American Airlines
Sun 7/196:32 am
BUF
- TYS
1 stop5h 58m
American Airlines
Deal found 5/11![American Airlines logo]()
$417
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:25 am
TYS
- BUF
2 stops12h 25m
Southwest
Tue 10/67:30 am
BUF
- TYS
2 stops9h 15m
Southwest
Deal found 5/14![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:10 am
TYS
- BUF
2 stops8h 05m
Southwest
Sun 8/96:20 am
BUF
- TYS
2 stops8h 40m
Southwest
Deal found 5/11![Southwest logo]()
$368
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/512:50 pm
TYS
- BUF
1 stop10h 25m
Southwest
Mon 10/1211:10 am
BUF
- TYS
1 stop5h 35m
Southwest
Deal found 5/15![Southwest logo]()
$382
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:40 am
TYS
- BUF
1 stop9h 20m
Southwest
Tue 6/1610:25 am
BUF
- TYS
2 stops10h 50m
Southwest
Deal found 5/12![Southwest logo]()
$384
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/168:10 am
TYS
- BUF
1 stop6h 10m
Southwest
Thu 6/1812:40 pm
BUF
- TYS
2 stops8h 30m
Southwest
Deal found 5/14![Southwest logo]()
$387
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated May 16, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated May 16, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/112:55 pm
TYS
- BUF
2 stops21h 46m
Multiple Airlines
Thu 6/48:49 pm
BUF
- TYS
1 stop26h 50m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$336
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:25 pm
TYS
- BUF
1 stop6h 34m
Delta
Wed 6/176:29 am
BUF
- TYS
1 stop3h 58m
Delta
Deal found 5/13![Delta logo]()
$323
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:25 pm
TYS
- BUF
1 stop6h 34m
Delta
Tue 6/166:00 am
BUF
- TYS
1 stop5h 09m
Delta
Deal found 5/14![Delta logo]()
$352
This Southwest deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1112:35 pm
TYS
- BUF
2 stops11h 35m
Southwest
Wed 6/176:25 am
BUF
- TYS
1 stop10h 35m
Southwest
Deal found 5/13![Southwest logo]()
$369
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:12 am
TYS
- BUF
1 stop4h 07m
American Airlines
Tue 6/167:32 pm
BUF
- TYS
1 stop4h 15m
American Airlines
Deal found 5/12![American Airlines logo]()
$332
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:12 am
TYS
- BUF
1 stop4h 07m
American Airlines
Mon 6/155:00 am
BUF
- TYS
1 stop5h 48m
American Airlines
Deal found 5/12![American Airlines logo]()
$348
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1712:45 pm
TYS
- BUF
2 stops8h 40m
Southwest
Fri 6/195:55 pm
BUF
- TYS
1 stop4h 35m
Southwest
Deal found 5/14![Southwest logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:30 am
TYS
- BUF
2 stops11h 42m
Multiple Airlines
Thu 6/259:02 pm
BUF
- TYS
1 stop26h 32m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:03 pm
TYS
- BUF
1 stop4h 51m
American Airlines
Sun 7/55:24 am
BUF
- TYS
1 stop6h 03m
American Airlines
Deal found 5/15![American Airlines logo]()
$372
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated May 16, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated May 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/112:55 pm
TYS
- BUF
2 stops21h 46m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2612:40 pm
TYS
- BUF
2 stops22h 54m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$156
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:03 pm
TYS
- BUF
1 stop4h 51m
American Airlines
Deal found 5/11![American Airlines logo]()
$178
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:15 pm
TYS
- BUF
1 stop6h 44m
Delta
Deal found 5/13![Delta logo]()
$179
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:53 pm
TYS
- BUF
1 stop5h 03m
American Airlines
Deal found 5/12![American Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:22 pm
TYS
- BUF
3 stops39h 18m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:03 pm
TYS
- BUF
1 stop24h 56m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:46 pm
TYS
- BUF
2 stops26h 18m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2210:03 pm
TYS
- BUF
1 stop20h 56m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2311:19 am
TYS
- BUF
1 stop4h 58m
American Airlines
Deal found 5/15![American Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:12 am
TYS
- BUF
2 stops9h 29m
American Airlines
Deal found 5/15![American Airlines logo]()
$339
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $215 (Kiwi.com) |
One-way from | $103 (Kiwi.com) |
Popular in | January |
Cheapest in | August |
Average price | $318 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 16, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 9/16
8:00 am-2:20 pm
1 stop6h 20m
Buffalo
Fri 9/18
12:30 pm-6:35 pm
1 stop6h 05m
$342
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 10/16
8:47 am-3:27 pm
1 stop6h 40m
Buffalo
Mon 10/19
7:40 pm-11:46 pm
1 stop4h 06m
$348
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 9/25
8:25 am-8:50 pm
2 stops12h 25m
Buffalo
Tue 10/6
7:30 am-4:45 pm
2 stops9h 15m
$358
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 8/6
7:10 am-3:15 pm
2 stops8h 05m
Buffalo
Sun 8/9
6:20 am-3:00 pm
2 stops8h 40m
$368
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 10/5
12:50 pm-11:15 pm
1 stop10h 25m
Buffalo
Mon 10/12
11:10 am-4:45 pm
1 stop5h 35m
$382
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 6/15
6:40 am-4:00 pm
1 stop9h 20m
Buffalo
Tue 6/16
10:25 am-9:15 pm
2 stops10h 50m
$384
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 6/16
8:10 am-2:20 pm
1 stop6h 10m
Buffalo
Thu 6/18
12:40 pm-9:10 pm
2 stops8h 30m
$387
Quickest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 7/17
6:00 am-10:16 am
1 stop4h 16m
Buffalo
Sun 7/19
6:32 am-12:30 pm
1 stop5h 58m
$417
Cheapest one-way
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 6/1
12:55 pm-10:41 am
2 stops21h 46m
$103
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 6/26
12:40 pm-11:34 am
2 stops22h 54m
$156
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, August is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $253). Flying from Knoxville to Buffalo in January is currently the most expensive (average of $617). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated May 16, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Overall
7.9
Entertainment
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Comfort
7.8
Overall
7.9
Entertainment
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Comfort
7.8
Overall
7.9
Entertainment
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden
West Seneca
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights
Alternative routes for Knoxville to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 16, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Buffalo by cabin class
Find flights from Knoxville to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on May 16, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on May 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Buffalo
Discover the top 2 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$159 | Average$273 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$328 | FlexibilityNo cancel fee | On-time71% |