$128+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Aug 16 — Aug 231
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Last-minute
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 17, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/214:18 pm
TYS
- BUF
1 stop25h 16m
Multiple Airlines
Tue 9/296:29 pm
BUF
- TYS
1 stop20h 13m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/712:50 pm
TYS
- BUF
2 stops22h 43m
Multiple Airlines
Thu 8/139:33 pm
BUF
- TYS
1 stop25h 11m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:40 pm
TYS
- BUF
2 stops21h 49m
Multiple Airlines
Thu 8/139:33 pm
BUF
- TYS
1 stop25h 11m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:54 am
TYS
- BUF
2 stops25h 27m
Multiple Airlines
Tue 9/296:29 pm
BUF
- TYS
1 stop20h 13m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/214:18 pm
TYS
- BUF
1 stop25h 16m
Multiple Airlines
Sun 9/271:16 pm
BUF
- TYS
2 stops30h 18m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:55 pm
TYS
- BUF
2 stops15h 26m
Multiple Airlines
Thu 10/18:54 pm
BUF
- TYS
1 stop26h 04m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/214:18 pm
TYS
- BUF
1 stop25h 16m
Multiple Airlines
Mon 9/281:16 pm
BUF
- TYS
2 stops44h 49m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/72:30 pm
TYS
- BUF
1 stop18h 53m
Multiple Airlines
Sun 9/131:16 pm
BUF
- TYS
2 stops30h 18m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$278
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:21 pm
TYS
- BUF
1 stop5h 38m
Delta
Wed 10/214:09 pm
BUF
- TYS
1 stop3h 59m
Delta
Deal found 7/13![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
TYS
- BUF
2 stops7h 12m
United Airlines
Tue 8/187:59 pm
BUF
- TYS
1 stop4h 00m
United Airlines
Deal found 7/14![United Airlines logo]()
$284
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 17, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 17, 2026.
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:45 am
TYS
- BUF
1 stop5h 31m
Delta
Thu 10/226:55 pm
BUF
- TYS
1 stop5h 04m
Delta
Deal found 7/13![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:45 am
TYS
- BUF
1 stop4h 06m
United Airlines
Mon 8/1710:30 am
BUF
- TYS
1 stop6h 28m
United Airlines
Deal found 7/13![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:00 pm
TYS
- BUF
1 stop9h 40m
Southwest
Sat 9/197:50 am
BUF
- TYS
2 stops11h 30m
Southwest
Deal found 7/15![Southwest logo]()
$315
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:15 am
TYS
- BUF
1 stop6h 51m
American Airlines
Sun 8/307:54 pm
BUF
- TYS
1 stop4h 05m
American Airlines
Deal found 7/16![American Airlines logo]()
$357
This United Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am
TYS
- BUF
2 stops8h 18m
United Airlines
Tue 9/297:59 pm
BUF
- TYS
1 stop4h 00m
United Airlines
Deal found 7/11![United Airlines logo]()
$284
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:00 am
TYS
- BUF
2 stops7h 20m
Southwest
Tue 9/299:45 am
BUF
- TYS
2 stops10h 05m
Southwest
Deal found 7/11![Southwest logo]()
$329
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:20 pm
TYS
- BUF
1 stop4h 24m
United Airlines
Sat 9/195:58 pm
BUF
- TYS
1 stop4h 51m
United Airlines
Deal found 7/15![United Airlines logo]()
$300
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:21 pm
TYS
- BUF
1 stop5h 38m
Delta
Sun 10/116:00 am
BUF
- TYS
1 stop5h 01m
Delta
Deal found 7/15![Delta logo]()
$346
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:05 am
TYS
- BUF
1 stop4h 25m
Southwest
Sun 9/276:20 am
BUF
- TYS
2 stops8h 40m
Southwest
Deal found 7/12![Southwest logo]()
$333
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:20 pm
TYS
- BUF
1 stop4h 24m
United Airlines
Wed 8/1210:30 am
BUF
- TYS
1 stop6h 28m
United Airlines
Deal found 7/14![United Airlines logo]()
$359
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated July 17, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated July 17, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:40 pm
TYS
- BUF
2 stops21h 49m
Multiple Airlines
Thu 8/139:33 pm
BUF
- TYS
1 stop25h 11m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$250
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:22 pm
TYS
- BUF
1 stop6h 36m
Delta
Tue 8/117:19 pm
BUF
- TYS
1 stop4h 33m
Delta
Deal found 7/13![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:40 am
TYS
- BUF
1 stop5h 28m
Delta
Fri 8/143:54 pm
BUF
- TYS
1 stop5h 40m
Delta
Deal found 7/13![Delta logo]()
$318
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:22 pm
TYS
- BUF
1 stop6h 36m
Delta
Wed 8/127:19 pm
BUF
- TYS
1 stop4h 35m
Delta
Deal found 7/13![Delta logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/712:50 pm
TYS
- BUF
2 stops22h 43m
Multiple Airlines
Thu 8/139:33 pm
BUF
- TYS
1 stop25h 11m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/93:56 pm
TYS
- BUF
1 stop27h 10m
Multiple Airlines
Thu 8/2011:36 am
BUF
- TYS
2 stops30h 59m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$291
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
TYS
- BUF
2 stops7h 12m
United Airlines
Tue 8/187:59 pm
BUF
- TYS
1 stop4h 00m
United Airlines
Deal found 7/14![United Airlines logo]()
$284
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:20 pm
TYS
- BUF
1 stop4h 24m
United Airlines
Mon 8/1710:30 am
BUF
- TYS
1 stop6h 28m
United Airlines
Deal found 7/14![United Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:51 pm
TYS
- BUF
2 stops43h 38m
Multiple Airlines
Sun 8/309:29 pm
BUF
- TYS
1 stop21h 34m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$322
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 17, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:58 pm
TYS
- BUF
2 stops40h 20m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$128
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:55 am
TYS
- BUF
1 stop5h 58m
Delta
Deal found 7/14![Delta logo]()
$140
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm
TYS
- BUF
2 stops8h 20m
Southwest
Deal found 7/14![Southwest logo]()
$145
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:40 pm
TYS
- BUF
1 stop4h 30m
Southwest
Deal found 7/14![Southwest logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:14 pm
TYS
- BUF
3 stops25h 20m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$204
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:45 am
TYS
- BUF
1 stop4h 06m
United Airlines
Deal found 7/15![United Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/303:38 pm
TYS
- BUF
2 stops43h 55m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$229
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $221 (Kiwi.com) |
One-way from | $128 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $396 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 17, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 10/13
5:45 am-11:16 am
1 stop5h 31m
Buffalo
Thu 10/22
6:55 pm-11:59 pm
1 stop5h 04m
$279
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 8/10
5:45 am-9:51 am
1 stop4h 06m
Buffalo
Mon 8/17
10:30 am-4:58 pm
1 stop6h 28m
$279
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 9/22
6:00 am-2:18 pm
2 stops8h 18m
Buffalo
Tue 9/29
7:59 pm-11:59 pm
1 stop4h 00m
$284
Quickest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 9/17
7:20 pm-11:44 pm
1 stop4h 24m
Buffalo
Sat 9/19
5:58 pm-10:49 pm
1 stop4h 51m
$300
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 9/17
1:00 pm-10:40 pm
1 stop9h 40m
Buffalo
Sat 9/19
7:50 am-7:20 pm
2 stops11h 30m
$315
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 9/22
7:00 am-2:20 pm
2 stops7h 20m
Buffalo
Tue 9/29
9:45 am-7:50 pm
2 stops10h 05m
$329
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 9/22
8:05 am-12:30 pm
1 stop4h 25m
Buffalo
Sun 9/27
6:20 am-3:00 pm
2 stops8h 40m
$333
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 10/6
6:21 pm-11:59 pm
1 stop5h 38m
Buffalo
Sun 10/11
6:00 am-11:01 am
1 stop5h 01m
$346
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 8/21
5:15 am-12:06 pm
1 stop6h 51m
Buffalo
Sun 8/30
7:54 pm-11:59 pm
1 stop4h 05m
$357
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 8/11
7:20 pm-11:44 pm
1 stop4h 24m
Buffalo
Wed 8/12
10:30 am-4:58 pm
1 stop6h 28m
$359
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, August is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $278). Flying from Knoxville to Buffalo in December is currently the most expensive (average of $798). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated July 17, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Boarding
8.1
Food
7.0
Overall
8.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Crew
8.6
Boarding
8.1
Food
7.0
Overall
8.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Crew
8.6
Boarding
8.1
Food
7.0
Overall
8.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Crew
8.6
Boarding
8.1
Food
7.0
Overall
8.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Alternative routes for Knoxville to Buffalo
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 17, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Buffalo by cabin class
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Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on July 17, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on July 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Buffalo
Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$159 | Average$300 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$253 | Average$393 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$397 | FlexibilityNo cancel fee | On-time63% |