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$129+ Cheap flights from Knoxville to Buffalo (TYS - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
abr. 23 — abr. 301
dj. 4/23
dj. 4/30
1 adult, Economy
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Cheap flight deals from Knoxville to Buffalo

Cheapest flights from Knoxville to Buffalo
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on març 24, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dc. 4/224:25 pm
TYS
-
BUF
2 stops19h 15m
Multiple Airlines
dg. 4/263:58 pm
BUF
-
TYS
1 stop25h 32m
Multiple Airlines
Deal found 3/20$246
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dj. 4/167:20 pm
TYS
-
BUF
1 stop4h 30m
United Airlines
dl. 4/206:02 pm
BUF
-
TYS
1 stop4h 32m
United Airlines
Deal found 3/23$279
This Delta deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dc. 4/157:50 am
TYS
-
BUF
1 stop3h 49m
Delta
dt. 4/2112:50 pm
BUF
-
TYS
1 stop3h 52m
Delta
Deal found 3/20$295
This United Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dt. 4/147:00 am
TYS
-
BUF
1 stop6h 13m
United Airlines
ds. 4/186:09 am
BUF
-
TYS
1 stop4h 41m
United Airlines
Deal found 3/20$303
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dt. 4/146:38 pm
TYS
-
BUF
1 stop5h 11m
American Airlines
ds. 4/185:42 pm
BUF
-
TYS
2 stops6h 13m
American Airlines
Deal found 3/20$308
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dj. 4/305:26 pm
TYS
-
BUF
1 stop5h 13m
Delta
dl. 5/46:05 am
BUF
-
TYS
1 stop4h 16m
Delta
Deal found 3/19$311
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dc. 4/154:25 pm
TYS
-
BUF
2 stops19h 15m
Multiple Airlines
dg. 4/193:58 pm
BUF
-
TYS
1 stop25h 32m
Multiple Airlines
Deal found 3/20$316
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dj. 4/168:05 am
TYS
-
BUF
1 stop3h 55m
Southwest
dl. 4/205:20 pm
BUF
-
TYS
1 stop3h 55m
Southwest
Deal found 3/20$321
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dj. 4/165:00 am
TYS
-
BUF
2 stops6h 58m
American Airlines
dl. 4/207:28 pm
BUF
-
TYS
1 stop4h 27m
American Airlines
Deal found 3/23$325
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dt. 4/146:38 pm
TYS
-
BUF
1 stop5h 11m
American Airlines
dg. 4/196:19 am
BUF
-
TYS
1 stop4h 42m
American Airlines
Deal found 3/20$326
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dv. 5/15:24 pm
TYS
-
BUF
1 stop5h 15m
Delta
dl. 5/46:05 am
BUF
-
TYS
1 stop4h 16m
Delta
Deal found 3/19$334

Find flight deals from Knoxville to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated març 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$246
(Kiwi.com)

One-way from

$129
(Kiwi.com)

Popular in

January

Cheapest in

June

Average price

$499
Provider with most accurate pricing for Knoxville McGhee Tyson-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Buffalo flights.
Search Deals
From Knoxville McGhee Tyson to Buffalo
Search Deals
One-way flight from Knoxville McGhee Tyson to Buffalo
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($148 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated març 24, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

ds. 5/2

7:50 am-11:45 am

1 stop3h 55m

Buffalo

dl. 5/4

6:05 am-10:21 am

1 stop4h 16m

$311

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

dc. 6/17

7:19 pm-11:59 pm

1 stop4h 40m

Buffalo

ds. 6/20

10:34 am-2:27 pm

1 stop3h 53m

$357

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

dc. 6/17

8:10 am-2:20 pm

1 stop6h 10m

Buffalo

ds. 6/20

5:25 pm-9:20 pm

1 stop3h 55m

$357

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

dv. 5/1

8:05 am-12:00 pm

1 stop3h 55m

Buffalo

dl. 5/4

6:00 am-2:10 pm

2 stops8h 10m

$362

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

dj. 5/21

7:15 am-6:59 pm

2 stops35h 44m

Buffalo

dg. 5/31

8:49 pm-11:37 pm

1 stop26h 48m

$366

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

dc. 6/24

12:45 pm-10:40 pm

2 stops9h 55m

Buffalo

ds. 6/27

5:25 pm-9:20 pm

1 stop3h 55m

$372

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

dt. 4/14

12:50 pm-10:15 pm

2 stops9h 25m

Buffalo

dg. 4/19

12:25 pm-9:05 pm

2 stops8h 40m

$394
Quickest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

dj. 5/21

8:05 am-12:00 pm

1 stop3h 55m

Buffalo

dg. 5/31

5:50 pm-10:00 pm

1 stop4h 10m

$407
Cheapest one-way

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

dj. 5/7

11:27 am-6:46 pm

2 stops31h 19m

$147

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

ds. 4/25

7:00 am-1:13 pm

1 stop6h 13m

$159

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/23

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Buffalo

What is the cheapest month to book a flight from Knoxville to Buffalo?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $160). Flying from Knoxville to Buffalo in February is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated març 24, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,320 reviews

Crew

8.5

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,320 reviews
Delta
7.9
Good
8,320 reviews

Crew

8.5

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.1
Good
11,491 reviews
Delta
7.9
Good
8,320 reviews

Crew

8.5

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Buffalo?

    United Airlines, Delta, and American Airlines can get you from Knoxville to Buffalo in just under 3h 49m. Your travel time can differ by up to 1h 22m. There are 567 mi between Knoxville and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Buffalo round-trip?

    Flying on Delta is currently your cheapest option to Buffalo, with prices starting at $159. Another option worth looking into is American Airlines, starting at $248 round trip. These flights start at 58% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to Buffalo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Buffalo.

  • Can I find deals for business class flights from Knoxville to Buffalo?

    Yes. Cheapflights offers flight deals from Knoxville to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Buffalo?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $160). Flying from Knoxville to Buffalo in February is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to Buffalo

Discover the top 2 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated març 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$159Average$248FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$318FlexibilityNo cancel feeOn-time71%

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