$179+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Jul 2 — Jul 91
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 2, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 2, 2026.
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:46 pm
TYS
- BUF
1 stop4h 13m
Delta
Thu 7/167:24 pm
BUF
- TYS
1 stop4h 28m
Delta
Deal found 5/31![Delta logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:20 pm
TYS
- BUF
1 stop25h 47m
Multiple Airlines
Thu 7/169:29 pm
BUF
- TYS
1 stop26h 04m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:23 pm
TYS
- BUF
1 stop6h 35m
Delta
Wed 7/157:24 pm
BUF
- TYS
1 stop4h 28m
Delta
Deal found 5/31![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:10 am
TYS
- BUF
1 stop4h 00m
Southwest
Wed 7/1511:00 am
BUF
- TYS
2 stops9h 25m
Southwest
Deal found 6/1![Southwest logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:20 pm
TYS
- BUF
1 stop23h 46m
Multiple Airlines
Thu 7/169:29 pm
BUF
- TYS
1 stop26h 04m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:00 am
TYS
- BUF
1 stop5h 42m
American Airlines
Wed 10/76:07 am
BUF
- TYS
1 stop6h 49m
American Airlines
Deal found 6/1![American Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/2412:45 pm
TYS
- BUF
2 stops9h 55m
Southwest
Wed 7/16:25 am
BUF
- TYS
1 stop10h 35m
Southwest
Deal found 5/31![Southwest logo]()
$318
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:05 pm
TYS
- BUF
1 stop5h 54m
Delta
Tue 7/147:24 pm
BUF
- TYS
1 stop4h 28m
Delta
Deal found 5/31![Delta logo]()
$320
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
TYS
- BUF
2 stops12h 04m
United Airlines
Wed 8/1210:30 am
BUF
- TYS
1 stop6h 28m
United Airlines
Deal found 6/1![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:50 am
TYS
- BUF
1 stop9h 45m
Southwest
Wed 10/77:30 am
BUF
- TYS
2 stops9h 15m
Southwest
Deal found 6/1![Southwest logo]()
$327
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 2, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 2, 2026.
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:10 am
TYS
- BUF
1 stop6h 10m
Southwest
Tue 7/1411:00 am
BUF
- TYS
2 stops9h 25m
Southwest
Deal found 5/31![Southwest logo]()
$312
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
TYS
- BUF
2 stops12h 04m
United Airlines
Wed 8/1210:30 am
BUF
- TYS
1 stop6h 28m
United Airlines
Deal found 6/1![United Airlines logo]()
$322
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:41 pm
TYS
- BUF
1 stop4h 18m
Delta
Mon 8/177:19 pm
BUF
- TYS
1 stop4h 33m
Delta
Deal found 5/28![Delta logo]()
$338
This Southwest deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/712:45 pm
TYS
- BUF
2 stops10h 00m
Southwest
Tue 7/144:25 pm
BUF
- TYS
1 stop4h 55m
Southwest
Deal found 5/29![Southwest logo]()
$312
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/812:45 pm
TYS
- BUF
2 stops10h 00m
Southwest
Wed 7/1510:25 am
BUF
- TYS
2 stops10h 55m
Southwest
Deal found 6/1![Southwest logo]()
$317
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:05 am
TYS
- BUF
1 stop5h 22m
Delta
Mon 10/197:40 pm
BUF
- TYS
1 stop4h 06m
Delta
Deal found 5/31![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:50 am
TYS
- BUF
1 stop9h 45m
Southwest
Wed 10/77:30 am
BUF
- TYS
2 stops9h 15m
Southwest
Deal found 6/1![Southwest logo]()
$327
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/912:35 pm
TYS
- BUF
2 stops11h 40m
Southwest
Tue 7/144:25 pm
BUF
- TYS
1 stop4h 55m
Southwest
Deal found 6/1![Southwest logo]()
$337
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/111:35 pm
TYS
- BUF
2 stops9h 40m
Southwest
Tue 7/144:25 pm
BUF
- TYS
1 stop4h 55m
Southwest
Deal found 6/1![Southwest logo]()
$347
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated June 2, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated June 2, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/2412:45 pm
TYS
- BUF
2 stops9h 55m
Southwest
Wed 7/16:25 am
BUF
- TYS
1 stop10h 35m
Southwest
Deal found 5/31![Southwest logo]()
$318
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:46 pm
TYS
- BUF
1 stop4h 13m
Delta
Thu 7/167:24 pm
BUF
- TYS
1 stop4h 28m
Delta
Deal found 5/31![Delta logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:20 pm
TYS
- BUF
1 stop23h 46m
Multiple Airlines
Thu 7/169:29 pm
BUF
- TYS
1 stop26h 04m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:23 pm
TYS
- BUF
1 stop6h 35m
Delta
Wed 7/157:24 pm
BUF
- TYS
1 stop4h 28m
Delta
Deal found 5/31![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:10 am
TYS
- BUF
1 stop4h 00m
Southwest
Wed 7/1511:00 am
BUF
- TYS
2 stops9h 25m
Southwest
Deal found 6/1![Southwest logo]()
$312
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:23 pm
TYS
- BUF
1 stop6h 35m
Delta
Wed 7/157:24 pm
BUF
- TYS
1 stop4h 28m
Delta
Deal found 5/31![Delta logo]()
$332
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:05 pm
TYS
- BUF
1 stop5h 54m
Delta
Tue 7/147:24 pm
BUF
- TYS
1 stop4h 28m
Delta
Deal found 5/31![Delta logo]()
$320
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/912:35 pm
TYS
- BUF
2 stops11h 40m
Southwest
Tue 7/144:25 pm
BUF
- TYS
1 stop4h 55m
Southwest
Deal found 6/1![Southwest logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:20 pm
TYS
- BUF
1 stop25h 47m
Multiple Airlines
Thu 7/169:29 pm
BUF
- TYS
1 stop26h 04m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$304
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 2, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 2, 2026.
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:30 am
TYS
- BUF
1 stop3h 42m
Delta
Deal found 5/28![Delta logo]()
$179
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/912:35 pm
TYS
- BUF
2 stops11h 40m
Southwest
Deal found 6/1![Southwest logo]()
$184
This Southwest deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:30 am
TYS
- BUF
1 stop8h 35m
Southwest
Deal found 5/29![Southwest logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2312:55 pm
TYS
- BUF
2 stops25h 00m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/53:38 pm
TYS
- BUF
2 stops22h 15m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$274
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am
TYS
- BUF
2 stops7h 46m
United Airlines
Deal found 5/28![United Airlines logo]()
$295
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $271 (Delta) |
One-way from | $179 (Delta) |
Popular in | January |
Cheapest in | August |
Average price | $356 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 2, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 7/8
8:10 am-2:20 pm
1 stop6h 10m
Buffalo
Tue 7/14
11:00 am-8:25 pm
2 stops9h 25m
$312
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 7/7
12:45 pm-10:45 pm
2 stops10h 00m
Buffalo
Tue 7/14
4:25 pm-9:20 pm
1 stop4h 55m
$312
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 7/8
12:45 pm-10:45 pm
2 stops10h 00m
Buffalo
Wed 7/15
10:25 am-9:20 pm
2 stops10h 55m
$317
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 8/11
7:00 am-7:04 pm
2 stops12h 04m
Buffalo
Wed 8/12
10:30 am-4:58 pm
1 stop6h 28m
$322
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sat 9/26
7:50 am-5:35 pm
1 stop9h 45m
Buffalo
Wed 10/7
7:30 am-4:45 pm
2 stops9h 15m
$327
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 7/9
12:35 pm-12:15 am
2 stops11h 40m
Buffalo
Tue 7/14
4:25 pm-9:20 pm
1 stop4h 55m
$337
Quickest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 8/14
7:41 pm-11:59 pm
1 stop4h 18m
Buffalo
Mon 8/17
7:19 pm-11:52 pm
1 stop4h 33m
$338
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sat 7/11
1:35 pm-11:15 pm
2 stops9h 40m
Buffalo
Tue 7/14
4:25 pm-9:20 pm
1 stop4h 55m
$347
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 10/16
10:05 am-3:27 pm
1 stop5h 22m
Buffalo
Mon 10/19
7:40 pm-11:46 pm
1 stop4h 06m
$351
Cheapest one-way
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 10/23
5:57 pm-11:55 pm
1 stop5h 58m
$179
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, August is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $253). Flying from Knoxville to Buffalo in January is currently the most expensive (average of $617). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated June 2, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Comfort
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Overall
7.9
Comfort
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Overall
7.9
Comfort
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 2, 2026.
Complete your trip
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Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on June 2, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 2, 2026.
Popular flight searches
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Top 2 airlines flying from Knoxville to Buffalo
Discover the top 2 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$159 | Average$273 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$253 | Average$362 | FlexibilityNo cancel fee | On-time71% |