$100+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
May 11 — May 181
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:27 am
TYS
- BUF
2 stops26h 27m
Multiple Airlines
Sun 5/178:49 pm
BUF
- TYS
1 stop20h 41m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:00 am
TYS
- BUF
2 stops10h 46m
Multiple Airlines
Sun 5/108:49 pm
BUF
- TYS
1 stop20h 41m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:15 pm
TYS
- BUF
1 stop6h 11m
Multiple Airlines
Fri 4/2412:18 pm
BUF
- TYS
2 stops29h 45m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:32 pm
TYS
- BUF
2 stops15h 01m
Multiple Airlines
Sun 5/178:49 pm
BUF
- TYS
1 stop20h 41m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:15 am
TYS
- BUF
1 stop4h 00m
Southwest
Wed 5/1311:55 am
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/8![Southwest logo]()
$295
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:50 am
TYS
- BUF
1 stop3h 55m
Delta
Mon 5/187:39 pm
BUF
- TYS
1 stop4h 17m
Delta
Deal found 4/6![Delta logo]()
$311
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:05 am
TYS
- BUF
2 stops10h 10m
Southwest
Mon 6/14:00 pm
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/8![Southwest logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:32 pm
TYS
- BUF
2 stops37h 17m
Multiple Airlines
Mon 4/2711:19 am
BUF
- TYS
1 stop6h 11m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$320
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 11, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 11, 2026.
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:50 am
TYS
- BUF
1 stop3h 55m
Delta
Mon 5/187:39 pm
BUF
- TYS
1 stop4h 17m
Delta
Deal found 4/6![Delta logo]()
$311
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/177:10 am
TYS
- BUF
2 stops8h 30m
Southwest
Sat 6/202:30 pm
BUF
- TYS
1 stop6h 50m
Southwest
Deal found 4/8![Southwest logo]()
$331
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:19 pm
TYS
- BUF
1 stop4h 33m
United Airlines
Sat 8/2910:54 am
BUF
- TYS
1 stop6h 05m
United Airlines
Deal found 4/8![United Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:56 am
TYS
- BUF
1 stop6h 48m
Delta
Sun 5/177:39 pm
BUF
- TYS
1 stop4h 17m
Delta
Deal found 4/10![Delta logo]()
$334
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:15 am
TYS
- BUF
1 stop6h 20m
Southwest
Tue 5/511:55 am
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/10![Southwest logo]()
$366
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:00 am
TYS
- BUF
1 stop6h 18m
United Airlines
Sat 5/21:57 pm
BUF
- TYS
1 stop6h 48m
United Airlines
Deal found 4/8![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:50 am
TYS
- BUF
2 stops9h 55m
Southwest
Sat 8/2910:50 am
BUF
- TYS
1 stop8h 30m
Southwest
Deal found 4/8![Southwest logo]()
$368
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:25 am
TYS
- BUF
1 stop4h 20m
Southwest
Sun 8/2311:30 am
BUF
- TYS
1 stop10h 15m
Southwest
Deal found 4/8![Southwest logo]()
$372
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/812:15 pm
TYS
- BUF
2 stops7h 30m
Southwest
Sun 5/1012:25 pm
BUF
- TYS
2 stops8h 40m
Southwest
Deal found 4/11![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:25 am
TYS
- BUF
1 stop4h 20m
Southwest
Sun 9/136:20 am
BUF
- TYS
2 stops8h 40m
Southwest
Deal found 4/8![Southwest logo]()
$412
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated April 11, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated April 11, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:15 pm
TYS
- BUF
1 stop6h 11m
Multiple Airlines
Fri 4/2412:18 pm
BUF
- TYS
2 stops29h 45m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:32 pm
TYS
- BUF
2 stops37h 17m
Multiple Airlines
Mon 4/2711:19 am
BUF
- TYS
1 stop6h 11m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$320
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:50 am
TYS
- BUF
1 stop3h 55m
Delta
Mon 5/187:39 pm
BUF
- TYS
1 stop4h 17m
Delta
Deal found 4/6![Delta logo]()
$311
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:15 am
TYS
- BUF
1 stop4h 00m
Southwest
Wed 5/1311:55 am
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/8![Southwest logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:00 am
TYS
- BUF
2 stops10h 46m
Multiple Airlines
Sun 5/108:49 pm
BUF
- TYS
1 stop20h 41m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:27 am
TYS
- BUF
2 stops26h 27m
Multiple Airlines
Sun 5/178:49 pm
BUF
- TYS
1 stop20h 41m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:32 pm
TYS
- BUF
2 stops15h 01m
Multiple Airlines
Sun 5/178:49 pm
BUF
- TYS
1 stop20h 41m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:05 am
TYS
- BUF
2 stops10h 10m
Southwest
Mon 6/14:00 pm
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/8![Southwest logo]()
$316
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 11, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1510:03 pm
TYS
- BUF
1 stop21h 09m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:27 am
TYS
- BUF
2 stops31h 19m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2912:55 pm
TYS
- BUF
2 stops22h 33m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:20 pm
TYS
- BUF
2 stops39h 20m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- BUF
2 stops21h 26m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:20 pm
TYS
- BUF
3 stops39h 20m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$151
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $205 (Kiwi.com) |
One-way from | $100 (Kiwi.com) |
Popular in | January |
Cheapest in | June |
Average price | $343 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sat 5/2
7:50 am-11:45 am
1 stop3h 55m
Buffalo
Mon 5/18
7:39 pm-11:56 pm
1 stop4h 17m
$311
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 6/17
7:10 am-3:40 pm
2 stops8h 30m
Buffalo
Sat 6/20
2:30 pm-9:20 pm
1 stop6h 50m
$331
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 5/14
11:56 am-6:44 pm
1 stop6h 48m
Buffalo
Sun 5/17
7:39 pm-11:56 pm
1 stop4h 17m
$334
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sat 8/22
7:19 pm-11:52 pm
1 stop4h 33m
Buffalo
Sat 8/29
10:54 am-4:59 pm
1 stop6h 05m
$357
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 4/29
8:15 am-2:35 pm
1 stop6h 20m
Buffalo
Tue 5/5
11:55 am-5:10 pm
1 stop5h 15m
$366
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sat 8/22
6:50 am-4:45 pm
2 stops9h 55m
Buffalo
Sat 8/29
10:50 am-7:20 pm
1 stop8h 30m
$368
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 8/20
8:25 am-12:45 pm
1 stop4h 20m
Buffalo
Sun 8/23
11:30 am-9:45 pm
1 stop10h 15m
$372
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 4/30
7:00 am-1:18 pm
1 stop6h 18m
Buffalo
Sat 5/2
1:57 pm-8:45 pm
1 stop6h 48m
$391
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 5/8
12:15 pm-7:45 pm
2 stops7h 30m
Buffalo
Sun 5/10
12:25 pm-9:05 pm
2 stops8h 40m
$407
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 9/10
8:25 am-12:45 pm
1 stop4h 20m
Buffalo
Sun 9/13
6:20 am-3:00 pm
2 stops8h 40m
$412
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, July is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $186). Flying from Knoxville to Buffalo in March is currently the most expensive (average of $272). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated April 11, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Food
7.2
Boarding
8.1
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Food
7.2
Boarding
8.1
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 11, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on April 11, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on April 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Buffalo
Discover the top 2 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$159 | Average$250 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$323 | FlexibilityNo cancel fee | On-time71% |