$147+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:07 am -
1 stop6h 23m
Tue 12/812:11 pm -
1 stop6h 45m
Deal found 10/29![Delta logo]()
$253
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
1 stop7h 17m
Tue 12/157:00 am -
2 stops7h 53m
Deal found 10/27![United Airlines logo]()
$258
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:00 pm -
1 stop9h 25m
Tue 12/87:25 am -
2 stops9h 15m
Deal found 10/29![Southwest logo]()
$264
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/159:45 am -
1 stop4h 35m
Fri 12/187:52 pm -
1 stop4h 23m
Deal found 10/27![United Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:55 am -
1 stop4h 10m
Mon 12/1411:20 am -
2 stops8h 30m
Deal found 10/26![Southwest logo]()
$299
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:30 am -
1 stop4h 26m
Wed 12/307:15 am -
1 stop7h 04m
Deal found 10/28![American Airlines logo]()
$303
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:30 pm -
2 stops7h 16m
Wed 11/186:00 am -
1 stop5h 30m
Deal found 10/25![United Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:00 pm -
1 stop9h 25m
Wed 12/912:45 pm -
2 stops7h 05m
Deal found 10/29![Southwest logo]()
$313
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/155:40 am -
1 stop5h 25m
Wed 3/172:10 pm -
1 stop7h 40m
Deal found 10/27![Delta logo]()
$320
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:00 am -
2 stops8h 20m
Wed 3/176:00 am -
1 stop5h 16m
Deal found 10/27![United Airlines logo]()
$325
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:00 pm -
1 stop9h 25m
Tue 12/87:25 am -
2 stops9h 15m
Deal found 10/29![Southwest logo]()
$264
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/159:45 am -
1 stop4h 35m
Fri 12/187:52 pm -
1 stop4h 23m
Deal found 10/27![United Airlines logo]()
$278
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:30 pm -
1 stop6h 29m
Wed 11/186:00 am -
1 stop5h 30m
Deal found 10/25![United Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:00 pm -
1 stop9h 25m
Wed 12/912:45 pm -
2 stops7h 05m
Deal found 10/29![Southwest logo]()
$313
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:00 am -
2 stops8h 20m
Wed 3/176:00 am -
1 stop5h 16m
Deal found 10/27![United Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:00 am -
2 stops8h 15m
Wed 12/307:52 pm -
1 stop4h 23m
Deal found 10/29![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/142:50 pm -
2 stops8h 45m
Tue 11/1711:20 am -
2 stops8h 30m
Deal found 10/26![Southwest logo]()
$380
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/151:00 pm -
2 stops9h 00m
Wed 3/1711:15 am -
2 stops9h 35m
Deal found 10/27![Southwest logo]()
$383
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:51 am -
2 stops8h 13m
Tue 11/1710:35 am -
1 stop4h 13m
Deal found 10/26![United Airlines logo]()
$375
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/141:55 pm -
1 stop5h 09m
Sat 11/216:00 am -
2 stops8h 48m
Deal found 10/29![United Airlines logo]()
$375
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated October 30, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:15 am -
1 stop5h 15m
Tue 11/173:55 pm -
1 stop4h 55m
Deal found 10/26![Southwest logo]()
$370
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/141:55 pm -
1 stop5h 09m
Sat 11/216:00 am -
2 stops8h 48m
Deal found 10/29![United Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:01 am -
1 stop6h 04m
Sat 11/2111:32 am -
1 stop6h 03m
Deal found 10/29![American Airlines logo]()
$413
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:30 pm -
1 stop6h 29m
Wed 11/186:00 am -
1 stop5h 30m
Deal found 10/25![United Airlines logo]()
$303
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:36 am -
1 stop6h 15m
Wed 11/2510:35 am -
1 stop5h 00m
Deal found 10/28![American Airlines logo]()
$366
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:45 am -
2 stops7h 35m
Wed 11/251:53 pm -
1 stop7h 01m
Deal found 10/28![United Airlines logo]()
$439
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:50 pm -
1 stop10h 35m
Wed 11/255:40 pm -
1 stop4h 05m
Deal found 10/27![Southwest logo]()
$449
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:10 pm -
1 stop6h 18m
Mon 11/306:00 am -
1 stop5h 28m
Deal found 10/26![Delta logo]()
$360
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:01 am -
1 stop4h 25m
Mon 11/307:44 pm -
1 stop4h 15m
Deal found 10/26![American Airlines logo]()
$363
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:45 am -
1 stop4h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![United Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:32 pm -
2 stops22h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$221
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:50 pm -
1 stop10h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Southwest logo]()
$269
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:45 am -
3 stops14h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![United Airlines logo]()
$661
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $253 (Delta) |
One-way from | $147 (United Airlines) |
Popular in | March |
Cheapest in | October |
Average price | $317 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 11/20
5:45 am-9:54 am
1 stop4h 09m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$147
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 11/20
9:32 pm-8:29 pm
2 stops22h 57m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$221
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 12/1
1:00 pm-10:25 pm
1 stop9h 25m
Buffalo
Tue 12/8
7:25 am-4:40 pm
2 stops9h 15m
$264
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Sun 11/22
12:50 pm-11:25 pm
1 stop10h 35m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$269
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 12/15
9:45 am-2:20 pm
1 stop4h 35m
Buffalo
Fri 12/18
7:52 pm-12:15 am
1 stop4h 23m
$278
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Mon 11/16
4:30 pm-10:59 pm
1 stop6h 29m
Buffalo
Wed 11/18
6:00 am-11:30 am
1 stop5h 30m
$303
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 12/1
1:00 pm-10:25 pm
1 stop9h 25m
Buffalo
Wed 12/9
12:45 pm-7:50 pm
2 stops7h 05m
$313
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Tue 12/15
6:00 am-2:20 pm
2 stops8h 20m
Buffalo
Wed 3/17
6:00 am-11:16 am
1 stop5h 16m
$325
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 12/25
6:00 am-2:15 pm
2 stops8h 15m
Buffalo
Wed 12/30
7:52 pm-12:15 am
1 stop4h 23m
$339
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Sat 11/14
10:51 am-7:04 pm
2 stops8h 13m
Buffalo
Tue 11/17
10:35 am-2:48 pm
1 stop4h 13m
$375
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated October 30, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Overall
7.9
Food
7.0
Comfort
8.0
Entertainment
7.4
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Boarding
8.1
Crew
8.6
Overall
7.9
Food
7.0
Comfort
8.0
Entertainment
7.4
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Boarding
8.1
Crew
8.6
Overall
7.9
Food
7.0
Comfort
8.0
Entertainment
7.4
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Boarding
8.1
Crew
8.6
Overall
7.9
Food
7.0
Comfort
8.0
Entertainment
7.4
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on October 30, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Buffalo
Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$232 | Average$326 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$397 | FlexibilityNo cancel fee | On-time63% |