$132+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Aug 23 — Aug 301
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 24, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 24, 2026.
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:15 am
TYS
- BUF
1 stop6h 51m
American Airlines
Tue 8/185:38 pm
BUF
- TYS
1 stop3h 56m
American Airlines
Deal found 7/22![American Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:32 pm
TYS
- BUF
1 stop5h 24m
American Airlines
Mon 8/315:00 am
BUF
- TYS
1 stop5h 45m
American Airlines
Deal found 7/22![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:01 pm
TYS
- BUF
2 stops22h 17m
Multiple Airlines
Sun 10/258:54 pm
BUF
- TYS
1 stop14h 20m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$296
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:55 pm
TYS
- BUF
1 stop5h 45m
Southwest
Wed 10/1412:35 pm
BUF
- TYS
2 stops8h 25m
Southwest
Deal found 7/21![Southwest logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:51 pm
TYS
- BUF
1 stop18h 32m
Multiple Airlines
Mon 8/3111:36 am
BUF
- TYS
2 stops46h 28m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:51 pm
TYS
- BUF
1 stop7h 39m
American Airlines
Mon 9/286:00 am
BUF
- TYS
1 stop7h 07m
American Airlines
Deal found 7/22![American Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:31 pm
TYS
- BUF
1 stop4h 05m
American Airlines
Mon 8/246:59 pm
BUF
- TYS
1 stop3h 59m
American Airlines
Deal found 7/20![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:40 am
TYS
- BUF
1 stop5h 30m
Delta
Sun 10/46:05 am
BUF
- TYS
1 stop5h 13m
Delta
Deal found 7/22![Delta logo]()
$323
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:11 pm
TYS
- BUF
1 stop5h 29m
American Airlines
Wed 9/236:30 am
BUF
- TYS
1 stop5h 11m
American Airlines
Deal found 7/24![American Airlines logo]()
$327
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:00 pm
TYS
- BUF
1 stop6h 59m
Delta
Sun 9/136:05 am
BUF
- TYS
1 stop5h 18m
Delta
Deal found 7/23![Delta logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:08 pm
TYS
- BUF
2 stops21h 10m
Multiple Airlines
Sun 10/188:54 pm
BUF
- TYS
1 stop14h 20m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$334
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 24, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 24, 2026.
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:55 pm
TYS
- BUF
1 stop5h 45m
Southwest
Wed 10/1412:35 pm
BUF
- TYS
2 stops8h 25m
Southwest
Deal found 7/21![Southwest logo]()
$304
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:45 am
TYS
- BUF
1 stop5h 31m
Delta
Sun 10/1812:22 pm
BUF
- TYS
1 stop5h 14m
Delta
Deal found 7/23![Delta logo]()
$323
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:20 pm
TYS
- BUF
1 stop4h 24m
United Airlines
Thu 8/136:12 am
BUF
- TYS
1 stop4h 25m
United Airlines
Deal found 7/21![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 am
TYS
- BUF
1 stop3h 51m
Delta
Mon 10/196:55 pm
BUF
- TYS
1 stop5h 04m
Delta
Deal found 7/19![Delta logo]()
$338
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:00 pm
TYS
- BUF
2 stops8h 55m
Southwest
Sun 9/136:45 am
BUF
- TYS
1 stop8h 15m
Southwest
Deal found 7/24![Southwest logo]()
$343
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:40 pm
TYS
- BUF
2 stops9h 10m
Southwest
Mon 8/315:40 am
BUF
- TYS
2 stops6h 40m
Southwest
Deal found 7/22![Southwest logo]()
$343
This Delta deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:23 pm
TYS
- BUF
1 stop5h 29m
Delta
Sun 9/206:20 am
BUF
- TYS
1 stop3h 58m
Delta
Deal found 7/21![Delta logo]()
$348
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:00 pm
TYS
- BUF
2 stops8h 50m
Southwest
Mon 8/245:40 am
BUF
- TYS
2 stops7h 45m
Southwest
Deal found 7/20![Southwest logo]()
$359
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated July 24, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated July 24, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:20 pm
TYS
- BUF
1 stop4h 24m
United Airlines
Thu 8/136:12 am
BUF
- TYS
1 stop4h 25m
United Airlines
Deal found 7/21![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:05 pm
TYS
- BUF
1 stop3h 50m
American Airlines
Tue 8/186:59 pm
BUF
- TYS
1 stop3h 59m
American Airlines
Deal found 7/22![American Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:22 pm
TYS
- BUF
1 stop6h 36m
Delta
Sat 8/156:27 am
BUF
- TYS
1 stop3h 49m
Delta
Deal found 7/20![Delta logo]()
$358
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:15 am
TYS
- BUF
1 stop6h 51m
American Airlines
Tue 8/185:38 pm
BUF
- TYS
1 stop3h 56m
American Airlines
Deal found 7/22![American Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:50 am
TYS
- BUF
2 stops9h 55m
Southwest
Tue 8/1812:35 pm
BUF
- TYS
2 stops6h 20m
Southwest
Deal found 7/22![Southwest logo]()
$369
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:31 pm
TYS
- BUF
1 stop4h 05m
American Airlines
Mon 8/246:59 pm
BUF
- TYS
1 stop3h 59m
American Airlines
Deal found 7/20![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:00 pm
TYS
- BUF
1 stop9h 40m
Southwest
Mon 8/245:40 am
BUF
- TYS
2 stops7h 45m
Southwest
Deal found 7/20![Southwest logo]()
$360
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:32 pm
TYS
- BUF
1 stop5h 24m
American Airlines
Mon 8/315:00 am
BUF
- TYS
1 stop5h 45m
American Airlines
Deal found 7/22![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:51 pm
TYS
- BUF
1 stop18h 32m
Multiple Airlines
Mon 8/3111:36 am
BUF
- TYS
2 stops46h 28m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:40 pm
TYS
- BUF
2 stops9h 10m
Southwest
Mon 8/315:40 am
BUF
- TYS
2 stops6h 40m
Southwest
Deal found 7/22![Southwest logo]()
$343
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2812:09 pm
TYS
- BUF
1 stop5h 53m
American Airlines
Sun 8/3010:43 am
BUF
- TYS
1 stop7h 21m
American Airlines
Deal found 7/23![American Airlines logo]()
$367
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 24, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/3012:55 pm
TYS
- BUF
2 stops21h 34m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$132
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:20 pm
TYS
- BUF
1 stop4h 24m
United Airlines
Deal found 7/23![United Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/612:52 pm
TYS
- BUF
2 stops21h 37m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$144
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:00 pm
TYS
- BUF
1 stop6h 59m
Delta
Deal found 7/23![Delta logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:03 pm
TYS
- BUF
2 stops17h 26m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:25 am
TYS
- BUF
2 stops25h 53m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$180
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/305:45 am
TYS
- BUF
1 stop4h 03m
United Airlines
Deal found 7/23![United Airlines logo]()
$184
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:05 pm
TYS
- BUF
1 stop4h 35m
American Airlines
Deal found 7/22![American Airlines logo]()
$195
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:22 pm
TYS
- BUF
1 stop6h 36m
Delta
Deal found 7/22![Delta logo]()
$224
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:05 am
TYS
- BUF
2 stops7h 10m
Southwest
Deal found 7/22![Southwest logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:20 pm
TYS
- BUF
1 stop25h 47m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$256
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $278 (American Airlines) |
One-way from | $132 (Kiwi.com) |
Popular in | December |
Cheapest in | November |
Average price | $396 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 24, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sat 10/10
2:55 pm-8:40 pm
1 stop5h 45m
Buffalo
Wed 10/14
12:35 pm-9:00 pm
2 stops8h 25m
$304
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 10/15
5:45 am-11:16 am
1 stop5h 31m
Buffalo
Sun 10/18
12:22 pm-5:36 pm
1 stop5h 14m
$323
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 10/16
7:25 am-11:16 am
1 stop3h 51m
Buffalo
Mon 10/19
6:55 pm-11:59 pm
1 stop5h 04m
$338
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 9/11
1:00 pm-9:55 pm
2 stops8h 55m
Buffalo
Sun 9/13
6:45 am-3:00 pm
1 stop8h 15m
$343
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 8/24
12:40 pm-9:50 pm
2 stops9h 10m
Buffalo
Mon 8/31
5:40 am-12:20 pm
2 stops6h 40m
$343
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 9/17
12:23 pm-5:52 pm
1 stop5h 29m
Buffalo
Sun 9/20
6:20 am-10:18 am
1 stop3h 58m
$348
Quickest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 8/12
7:20 pm-11:44 pm
1 stop4h 24m
Buffalo
Thu 8/13
6:12 am-10:37 am
1 stop4h 25m
$359
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 8/17
1:00 pm-9:50 pm
2 stops8h 50m
Buffalo
Mon 8/24
5:40 am-1:25 pm
2 stops7h 45m
$359
Cheapest one-way
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Mon 11/9
5:57 pm-11:55 pm
1 stop5h 58m
$140
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sun 9/6
12:52 pm-10:29 am
2 stops21h 37m
$144
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, November is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $283). Flying from Knoxville to Buffalo in December is currently the most expensive (average of $798). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Airfare is below average for this route at the moment.
Knoxville to Buffalo flights typically cost between $302 and $416 in August.The cheapest round-trip price found within the last 5 days was $278 on American Airlines (Aug 15-Aug 18).
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated July 24, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Alternative routes for Knoxville to Buffalo
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 24, 2026.
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Knoxville and Buffalo flights
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Other flights from Knoxville
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Top 3 airlines flying from Knoxville to Buffalo
Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$159 | Average$300 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$253 | Average$393 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$397 | FlexibilityNo cancel fee | On-time63% |