HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$118+ Cheap flights from Knoxville to Buffalo (TYS - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Jan 7 — Jan 141
Wed 1/7
Wed 1/14
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Buffalo

Cheapest flights from Knoxville to Buffalo
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

This United Airlines deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:45 amTYS - BUF
1 stop4h 01mUnited Airlines
Sat 12/277:48 pmBUF - TYS
1 stop4h 11mUnited Airlines
Deal found 12/7$467
This American Airlines deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:42 amTYS - BUF
1 stop5h 25mAmerican Airlines
Sun 12/286:00 amBUF - TYS
1 stop4h 24mAmerican Airlines
Deal found 12/7$598
This American Airlines deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:00 amTYS - BUF
2 stops7h 17mAmerican Airlines
Sat 12/271:15 pmBUF - TYS
2 stops6h 51mAmerican Airlines
Deal found 12/7$809

Find flight deals from Knoxville to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 8, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$235
(American Airlines)

One-way from

$118
(American Airlines)

Popular in

December

Cheapest in

March

Average price

$555
Provider with most accurate pricing for Knoxville McGhee Tyson-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Buffalo flights.
Search Deals
From Knoxville McGhee Tyson to Buffalo
Search Deals
One-way flight from Knoxville McGhee Tyson to Buffalo
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($59 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 8, 2025.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Knoxville

Fly to

Buffalo

Route

Depart

Return

Price

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 1/17

8:09 am-12:08 pm

1 stop3h 59m

Buffalo

Tue 1/20

7:30 am-12:46 pm

1 stop5h 16m

$235

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 1/9

6:18 pm-5:38 pm

1 stop23h 20m

Buffalo

Mon 1/12

9:08 am-10:28 pm

1 stop13h 20m

$265

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/25

7:30 am-11:43 am

1 stop4h 13m

Buffalo

Sat 2/28

6:03 am-12:08 pm

1 stop6h 05m

$277

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 1/1

5:42 am-11:07 am

1 stop5h 25m

Buffalo

Thu 1/8

5:16 pm-10:09 pm

1 stop4h 53m

$286

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 1/10

6:45 am-1:24 pm

1 stop6h 39m

Buffalo

Tue 1/13

9:55 am-2:49 pm

1 stop4h 54m

$347

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/25

10:17 am-4:54 pm

2 stops6h 37m

Buffalo

Sat 2/28

11:24 am-6:13 pm

2 stops6h 49m

$347

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 1/1

5:42 am-11:07 am

1 stop5h 25m

$118

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 1/6

1:00 pm-4:59 pm

1 stop3h 59m

$139

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 1/6

4:00 pm-11:42 pm

2 stops7h 42m

$144

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sun 12/28

5:08 pm-10:44 pm

1 stop5h 36m

$189

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/7

Showing 1-10 of 13 results
1
2

Compare providers for flights from Knoxville to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Buffalo

What is the cheapest month to book a flight from Knoxville to Buffalo?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $159). Flying from Knoxville to Buffalo in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to BUF?

Find hourly flight availability from Knoxville to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 8, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Buffalo in the afternoon. If you’re flexible enough to do this you can expect to save up to 30% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated December 8, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,013 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,013 reviews
Delta
7.9
Good
8,013 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
11,042 reviews
Delta
7.9
Good
8,013 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Buffalo?

    American Airlines and Delta can get you from Knoxville to Buffalo in just under 3h 59m. Your travel time can differ by up to 14m. There are 567 mi between Knoxville and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Buffalo round-trip?

    Flying on Delta is currently your cheapest option to Buffalo, with prices starting at $164. Another option worth looking into is American Airlines, starting at $224 round trip. These flights start at 50% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to Buffalo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Buffalo.

  • Can I find deals for business class flights from Knoxville to Buffalo?

    Yes. Cheapflights offers flight deals from Knoxville to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Buffalo?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $159). Flying from Knoxville to Buffalo in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to LaGuardia flights
Nashville to John F Kennedy Intl flights
Nashville to Newark flights
Memphis to LaGuardia flights
Memphis to John F Kennedy Intl flights
Chattanooga to LaGuardia flights
Knoxville to LaGuardia flights
Memphis to Newark flights
Chattanooga to John F Kennedy Intl flights
Knoxville to John F Kennedy Intl flights
Knoxville to Newark flights
Chattanooga to Newark flights
Nashville to Syracuse flights
Nashville to Buffalo flights
Nashville to Stewart flights
Blountville to John F Kennedy Intl flights
Knoxville to Stewart flights
Blountville to LaGuardia flights
Blountville to Newark flights
Nashville to Albany flights
Memphis to Stewart flights
Memphis to Buffalo flights
Chattanooga to Buffalo flights
Nashville to Rochester flights
Nashville to White Plains flights
Knoxville to Rochester flights
Knoxville to White Plains flights
Knoxville to Syracuse flights
Memphis to White Plains flights
Chattanooga to Syracuse flights
Knoxville to Islip flights
Knoxville to Albany flights
Memphis to Rochester flights
Blountville to Albany flights
Chattanooga to Rochester flights
Chattanooga to Stewart flights
Nashville to Islip flights
Memphis to Albany flights
Memphis to Syracuse flights
Blountville to Stewart flights
Nashville to Ithaca flights
Chattanooga to Albany flights
Blountville to Syracuse flights
Knoxville to Ithaca flights
Chattanooga to White Plains flights
Blountville to White Plains flights
Blountville to Buffalo flights
Memphis to Binghamton flights
Nashville to Elmira flights

Top 2 airlines flying from Knoxville to Buffalo

Discover the top 2 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 8, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$164Average$248FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$224Average$322FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.