$143+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Oct 2 — Oct 91
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:28 pm -
1 stop6h 25m
Wed 9/306:20 am -
1 stop3h 58m
Deal found 9/1![Delta logo]()
$287
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop6h 46m
Mon 10/197:53 pm -
1 stop4h 02m
Deal found 9/1![American Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
2 stops17h 55m
Thu 10/2212:53 pm -
1 stop23h 21m
Deal found 9/1![Multiple Airlines logo]()
$312
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:25 pm -
1 stop4h 25m
Wed 10/76:30 am -
2 stops8h 12m
Deal found 9/1![United Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:55 am -
1 stop4h 10m
Mon 12/1411:20 am -
2 stops8h 25m
Deal found 8/29![Southwest logo]()
$354
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 am -
1 stop6h 12m
Sun 10/46:27 am -
1 stop4h 04m
Deal found 8/31![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:45 am -
1 stop3h 50m
Wed 9/306:30 am -
2 stops8h 12m
Deal found 9/1![United Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:45 am -
1 stop6h 31m
Sat 10/311:53 pm -
1 stop7h 01m
Deal found 9/1![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:50 am -
1 stop3h 52m
Mon 11/237:44 pm -
1 stop4h 15m
Deal found 9/1![American Airlines logo]()
$368
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:23 pm -
1 stop5h 36m
Sun 10/256:00 am -
1 stop4h 54m
Deal found 8/31![Delta logo]()
$358
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:45 am -
2 stops7h 35m
Sat 10/311:53 pm -
1 stop7h 01m
Deal found 9/1![United Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:25 pm -
2 stops12h 50m
Sun 10/259:00 am -
2 stops10h 05m
Deal found 8/31![Southwest logo]()
$424
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
2 stops8h 23m
Mon 10/266:00 am -
1 stop5h 30m
Deal found 8/29![United Airlines logo]()
$459
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated September 2, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated September 2, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:28 pm -
1 stop6h 25m
Wed 9/306:20 am -
1 stop3h 58m
Deal found 9/1![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:45 am -
1 stop3h 50m
Wed 9/306:30 am -
2 stops8h 12m
Deal found 9/1![United Airlines logo]()
$363
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 am -
1 stop6h 12m
Sun 10/46:27 am -
1 stop4h 04m
Deal found 8/31![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:25 pm -
1 stop4h 25m
Wed 10/76:30 am -
2 stops8h 12m
Deal found 9/1![United Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
2 stops17h 55m
Thu 10/2212:53 pm -
1 stop23h 21m
Deal found 9/1![Multiple Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1311:45 am -
1 stop3h 28m
Thu 10/226:00 am -
1 stop5h 02m
Deal found 9/1![Delta logo]()
$373
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop6h 46m
Mon 10/197:53 pm -
1 stop4h 02m
Deal found 9/1![American Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:25 pm -
2 stops12h 50m
Sun 10/257:00 pm -
1 stop3h 45m
Deal found 8/31![Southwest logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:45 am -
1 stop6h 31m
Sat 10/311:53 pm -
1 stop7h 01m
Deal found 9/1![United Airlines logo]()
$367
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 2, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:08 pm -
2 stops21h 51m
Deal found 8/29![Multiple Airlines logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:22 pm -
1 stop29h 27m
Deal found 8/31![Multiple Airlines logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/271:19 pm -
2 stops23h 36m
Deal found 8/31![Multiple Airlines logo]()
$170
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:18 pm -
1 stop6h 41m
Deal found 8/29![Delta logo]()
$175
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/277:33 am -
1 stop3h 49m
Deal found 8/31![Delta logo]()
$350
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/287:25 pm -
3 stops21h 18m
Deal found 8/31![United Airlines logo]()
$463
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $287 (Delta) |
One-way from | $143 (Kiwi.com) |
Popular in | March |
Cheapest in | May |
Average price | $328 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 10/23
6:23 pm-11:59 pm
1 stop5h 36m
Buffalo
Sun 10/25
6:00 am-10:54 am
1 stop4h 54m
$358
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Wed 10/28
6:45 am-2:20 pm
2 stops7h 35m
Buffalo
Sat 10/31
1:53 pm-8:54 pm
1 stop7h 01m
$372
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 10/23
7:25 pm-8:15 am
2 stops12h 50m
Buffalo
Sun 10/25
9:00 am-7:05 pm
2 stops10h 05m
$424
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 10/23
6:00 am-2:23 pm
2 stops8h 23m
Buffalo
Mon 10/26
6:00 am-11:30 am
1 stop5h 30m
$459
Cheapest one-way
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Thu 10/15
3:08 pm-12:59 pm
2 stops21h 51m
$143
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Mon 9/28
12:22 pm-5:49 pm
1 stop29h 27m
$146
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Thu 10/15
5:18 pm-11:59 pm
1 stop6h 41m
$175
Quickest one-way
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Sun 9/27
7:33 am-11:22 am
1 stop3h 49m
$350
Sorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, May is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $318). Flying from Knoxville to Buffalo in March is currently the most expensive (average of $682). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Airfare is typical for this route at the moment.
Knoxville to Buffalo flights typically cost between $266 and $383 in September.The cheapest round-trip price found within the last 5 days was $287 on Delta (Sep 28-Sep 30).
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 2, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 2, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on September 2, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Buffalo
Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$232 | Average$300 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$397 | FlexibilityNo cancel fee | On-time63% |