$114+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
May 22 — May 291
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Best
Last-minute
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:33 pm
TYS
- BUF
1 stop4h 26m
Delta
Tue 6/24:55 pm
BUF
- TYS
1 stop7h 06m
Delta
Deal found 4/20![Delta logo]()
$233
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:33 pm
TYS
- BUF
1 stop4h 26m
Delta
Tue 5/266:15 am
BUF
- TYS
1 stop6h 55m
Delta
Deal found 4/21![Delta logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:42 pm
TYS
- BUF
1 stop27h 30m
Multiple Airlines
Mon 6/157:57 pm
BUF
- TYS
1 stop19h 58m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:27 am
TYS
- BUF
2 stops26h 27m
Multiple Airlines
Sat 5/92:47 pm
BUF
- TYS
1 stop21h 37m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$264
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:05 am
TYS
- BUF
2 stops9h 30m
Southwest
Tue 5/2611:55 am
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/21![Southwest logo]()
$281
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:05 am
TYS
- BUF
2 stops11h 10m
Southwest
Tue 6/211:55 am
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/20![Southwest logo]()
$307
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:30 am
TYS
- BUF
1 stop3h 55m
Southwest
Thu 8/2712:30 pm
BUF
- TYS
1 stop6h 05m
Southwest
Deal found 4/20![Southwest logo]()
$319
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:27 am
TYS
- BUF
2 stops26h 27m
Multiple Airlines
Sat 5/92:47 pm
BUF
- TYS
1 stop21h 37m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$264
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:05 am
TYS
- BUF
2 stops11h 10m
Southwest
Tue 6/211:55 am
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/20![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:19 pm
TYS
- BUF
1 stop4h 40m
United Airlines
Wed 6/175:52 pm
BUF
- TYS
1 stop6h 38m
United Airlines
Deal found 4/17![United Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:20 pm
TYS
- BUF
1 stop4h 35m
Delta
Mon 10/194:30 pm
BUF
- TYS
1 stop5h 15m
Delta
Deal found 4/19![Delta logo]()
$357
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:20 pm
TYS
- BUF
1 stop4h 38m
Delta
Sun 10/47:40 pm
BUF
- TYS
1 stop4h 07m
Delta
Deal found 4/21![Delta logo]()
$357
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/2412:45 pm
TYS
- BUF
2 stops8h 40m
Southwest
Thu 6/255:55 pm
BUF
- TYS
1 stop4h 35m
Southwest
Deal found 4/18![Southwest logo]()
$372
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:19 pm
TYS
- BUF
1 stop4h 40m
United Airlines
Mon 6/16:00 am
BUF
- TYS
1 stop4h 42m
United Airlines
Deal found 4/20![United Airlines logo]()
$382
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:25 am
TYS
- BUF
2 stops12h 25m
Southwest
Mon 9/145:40 am
BUF
- TYS
2 stops7h 45m
Southwest
Deal found 4/19![Southwest logo]()
$373
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:33 pm
TYS
- BUF
1 stop4h 26m
Delta
Mon 5/116:25 am
BUF
- TYS
1 stop3h 56m
Delta
Deal found 4/21![Delta logo]()
$388
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:40 am
TYS
- BUF
2 stops8h 50m
Southwest
Wed 6/1712:50 pm
BUF
- TYS
2 stops7h 30m
Southwest
Deal found 4/17![Southwest logo]()
$393
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:05 am
TYS
- BUF
2 stops10h 10m
Southwest
Sat 5/96:00 am
BUF
- TYS
2 stops9h 20m
Southwest
Deal found 4/17![Southwest logo]()
$418
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated April 22, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated April 22, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:10 pm
TYS
- BUF
1 stop16h 57m
Multiple Airlines
Sun 5/38:08 pm
BUF
- TYS
2 stops25h 40m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:27 am
TYS
- BUF
2 stops26h 27m
Multiple Airlines
Sat 5/92:47 pm
BUF
- TYS
1 stop21h 37m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$264
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:33 pm
TYS
- BUF
1 stop4h 26m
Delta
Mon 5/116:25 am
BUF
- TYS
1 stop3h 56m
Delta
Deal found 4/21![Delta logo]()
$388
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:00 am
TYS
- BUF
2 stops6h 58m
American Airlines
Mon 5/117:28 pm
BUF
- TYS
1 stop4h 27m
American Airlines
Deal found 4/21![American Airlines logo]()
$393
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:33 pm
TYS
- BUF
1 stop4h 26m
Delta
Tue 5/266:15 am
BUF
- TYS
1 stop6h 55m
Delta
Deal found 4/21![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:05 am
TYS
- BUF
2 stops9h 30m
Southwest
Tue 5/2611:55 am
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/21![Southwest logo]()
$281
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:33 pm
TYS
- BUF
1 stop4h 26m
Delta
Tue 6/24:55 pm
BUF
- TYS
1 stop7h 06m
Delta
Deal found 4/20![Delta logo]()
$233
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:05 am
TYS
- BUF
2 stops11h 10m
Southwest
Tue 6/211:55 am
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 4/20![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:19 pm
TYS
- BUF
1 stop4h 40m
United Airlines
Mon 6/16:00 am
BUF
- TYS
1 stop4h 42m
United Airlines
Deal found 4/20![United Airlines logo]()
$382
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:15 am
TYS
- BUF
2 stops29h 39m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:02 pm
TYS
- BUF
2 stops21h 39m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$115
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:20 pm
TYS
- BUF
1 stop4h 38m
Delta
Deal found 4/21![Delta logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:04 pm
TYS
- BUF
2 stops17h 36m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:45 am
TYS
- BUF
2 stops27h 56m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$142
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:12 am
TYS
- BUF
1 stop4h 07m
American Airlines
Deal found 4/21![American Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/297:22 pm
TYS
- BUF
1 stop23h 50m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$146
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:53 pm
TYS
- BUF
1 stop5h 03m
American Airlines
Deal found 4/17![American Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:56 am
TYS
- BUF
2 stops22h 45m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$155
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:45 am
TYS
- BUF
1 stop4h 06m
United Airlines
Deal found 4/17![United Airlines logo]()
$156
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/91:52 pm
TYS
- BUF
1 stop7h 09m
United Airlines
Deal found 4/18![United Airlines logo]()
$159
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (Delta) |
One-way from | $114 (Kiwi.com) |
Popular in | January |
Cheapest in | June |
Average price | $343 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 5/7
11:27 am-1:54 pm
2 stops26h 27m
Buffalo
Sat 5/9
2:47 pm-12:24 pm
1 stop21h 37m
$264
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 5/26
7:05 am-6:15 pm
2 stops11h 10m
Buffalo
Tue 6/2
11:55 am-5:10 pm
1 stop5h 15m
$307
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 6/12
7:19 pm-11:59 pm
1 stop4h 40m
Buffalo
Wed 6/17
5:52 pm-12:30 am
1 stop6h 38m
$326
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 10/16
7:20 pm-11:55 pm
1 stop4h 35m
Buffalo
Mon 10/19
4:30 pm-9:45 pm
1 stop5h 15m
$357
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 10/1
7:20 pm-11:58 pm
1 stop4h 38m
Buffalo
Sun 10/4
7:40 pm-11:47 pm
1 stop4h 07m
$357
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 6/24
12:45 pm-9:25 pm
2 stops8h 40m
Buffalo
Thu 6/25
5:55 pm-10:30 pm
1 stop4h 35m
$372
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 9/10
8:25 am-8:50 pm
2 stops12h 25m
Buffalo
Mon 9/14
5:40 am-1:25 pm
2 stops7h 45m
$373
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 5/29
7:19 pm-11:59 pm
1 stop4h 40m
Buffalo
Mon 6/1
6:00 am-10:42 am
1 stop4h 42m
$382
Quickest round-trip
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 5/7
7:33 pm-11:59 pm
1 stop4h 26m
Buffalo
Mon 5/11
6:25 am-10:21 am
1 stop3h 56m
$388
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 6/12
6:40 am-3:30 pm
2 stops8h 50m
Buffalo
Wed 6/17
12:50 pm-8:20 pm
2 stops7h 30m
$393
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, June is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $248). Flying from Knoxville to Buffalo in January is currently the most expensive (average of $617). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated April 22, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Overall
7.9
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Crew
8.5
Food
7.2
Overall
7.9
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Crew
8.5
Food
7.2
Overall
7.9
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
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Top 2 airlines flying from Knoxville to Buffalo
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$159 | Average$250 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$323 | FlexibilityNo cancel fee | On-time71% |