$193+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Sep 26 — Oct 31
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 27, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 27, 2026.
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:40 am -
1 stop5h 36m
Wed 10/216:15 am -
1 stop4h 02m
Deal found 8/22![Delta logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:57 pm -
2 stops23h 53m
Tue 10/66:51 pm -
1 stop27h 50m
Deal found 8/23![Multiple Airlines logo]()
$291
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
2 stops9h 10m
Wed 10/217:59 pm -
1 stop4h 00m
Deal found 8/22![United Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
2 stops17h 55m
Thu 10/2212:53 pm -
1 stop23h 21m
Deal found 8/25![Multiple Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop6h 46m
Mon 10/197:53 pm -
1 stop4h 02m
Deal found 8/26![American Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:55 pm -
2 stops7h 50m
Tue 10/208:00 am -
2 stops8h 40m
Deal found 8/22![Southwest logo]()
$318
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
2 stops12h 25m
Mon 10/192:50 pm -
1 stop6h 40m
Deal found 8/22![Southwest logo]()
$319
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:40 am -
1 stop5h 30m
Sun 10/46:05 am -
1 stop5h 13m
Deal found 8/24![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:15 am -
1 stop5h 51m
Sun 9/205:37 am -
1 stop5h 01m
Deal found 8/25![American Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:55 pm -
2 stops7h 50m
Wed 10/219:45 am -
2 stops6h 55m
Deal found 8/22![Southwest logo]()
$349
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 am -
1 stop6h 12m
Sun 10/46:27 am -
1 stop4h 04m
Deal found 8/26![American Airlines logo]()
$358
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 27, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 27, 2026.
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
2 stops12h 25m
Mon 10/192:50 pm -
1 stop6h 40m
Deal found 8/22![Southwest logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 am -
1 stop6h 12m
Sun 10/46:27 am -
1 stop4h 04m
Deal found 8/22![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:45 am -
1 stop4h 09m
Sat 11/216:00 am -
1 stop5h 30m
Deal found 8/27![United Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:55 pm -
2 stops7h 50m
Wed 10/219:45 am -
2 stops6h 55m
Deal found 8/22![Southwest logo]()
$349
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2810:45 am -
1 stop6h 17m
Sat 10/3110:51 am -
2 stops10h 03m
Deal found 8/25![United Airlines logo]()
$372
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:53 pm -
2 stops9h 19m
Sun 9/206:10 am -
1 stop4h 27m
Deal found 8/25![United Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:05 am -
2 stops7h 20m
Sat 11/2112:50 pm -
2 stops9h 50m
Deal found 8/27![Southwest logo]()
$387
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated August 27, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated August 27, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/75:45 am -
1 stop4h 03m
Fri 9/116:55 am -
1 stop6h 23m
Deal found 8/23![United Airlines logo]()
$419
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/812:45 pm -
2 stops8h 25m
Thu 9/1012:30 pm -
2 stops7h 30m
Deal found 8/24![Southwest logo]()
$429
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:25 am -
2 stops12h 30m
Tue 9/158:55 am -
2 stops10h 05m
Deal found 8/27![Southwest logo]()
$435
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:45 am -
1 stop4h 03m
Thu 9/175:57 pm -
1 stop4h 52m
Deal found 8/23![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:15 am -
1 stop5h 51m
Sun 9/205:37 am -
1 stop5h 01m
Deal found 8/26![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:15 am -
1 stop5h 51m
Sun 9/205:37 am -
1 stop5h 01m
Deal found 8/25![American Airlines logo]()
$347
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:53 pm -
2 stops9h 19m
Sun 9/206:10 am -
1 stop4h 27m
Deal found 8/25![United Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:19 pm -
2 stops23h 36m
Sun 9/2712:49 pm -
1 stop27h 54m
Deal found 8/22![Multiple Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:30 am -
1 stop6h 12m
Sun 9/277:00 am -
1 stop4h 53m
Deal found 8/22![American Airlines logo]()
$387
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 27, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:54 pm -
2 stops22h 56m
Deal found 8/25![Multiple Airlines logo]()
$193
This Southwest deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:25 am -
1 stop4h 20m
Deal found 8/25![Southwest logo]()
$196
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am -
2 stops8h 18m
Deal found 8/25![United Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/34:57 pm -
3 stops49h 12m
Deal found 8/26![Multiple Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:08 am -
1 stop5h 51m
Deal found 8/26![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/307:15 am -
1 stop4h 07m
Deal found 8/25![Delta logo]()
$341
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am -
2 stops7h 18m
Deal found 8/26![United Airlines logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/3010:54 am -
3 stops46h 29m
Deal found 8/25![Multiple Airlines logo]()
$345
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/307:00 am -
2 stops7h 18m
Deal found 8/25![United Airlines logo]()
$346
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $287 (Delta) |
One-way from | $193 (Kiwi.com) |
Popular in | December |
Cheapest in | November |
Average price | $402 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 27, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Thu 10/15
7:25 pm-7:50 am
2 stops12h 25m
Buffalo
Mon 10/19
2:50 pm-9:30 pm
1 stop6h 40m
$319
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Sat 10/17
2:55 pm-10:45 pm
2 stops7h 50m
Buffalo
Wed 10/21
9:45 am-4:40 pm
2 stops6h 55m
$349
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Thu 10/1
6:30 am-12:42 pm
1 stop6h 12m
Buffalo
Sun 10/4
6:27 am-10:31 am
1 stop4h 04m
$358
Quickest round-trip
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 11/20
5:45 am-9:54 am
1 stop4h 09m
Buffalo
Sat 11/21
6:00 am-11:30 am
1 stop5h 30m
$367
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Wed 10/28
10:45 am-5:02 pm
1 stop6h 17m
Buffalo
Sat 10/31
10:51 am-8:54 pm
2 stops10h 03m
$372
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Sat 9/19
1:53 pm-11:12 pm
2 stops9h 19m
Buffalo
Sun 9/20
6:10 am-10:37 am
1 stop4h 27m
$377
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 11/20
7:05 am-2:25 pm
2 stops7h 20m
Buffalo
Sat 11/21
12:50 pm-10:40 pm
2 stops9h 50m
$387
Cheapest one-way
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 9/11
1:54 pm-12:50 pm
2 stops22h 56m
$193
Quickest one-way
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 9/11
8:25 am-12:45 pm
1 stop4h 20m
$196
KnoxvilleBuffalo
TYS Knoxville McGhee Tyson - BUF Buffalo
TYSBUF
Knoxville McGhee Tyson
Fri 9/11
5:45 pm-11:52 pm
1 stop6h 07m
$196
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
What is the cheapest month to book a flight from Knoxville to Buffalo?
Currently, November is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $283). Flying from Knoxville to Buffalo in December is currently the most expensive (average of $798). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Buffalo?
Airfare is typical for this route at the moment.
Knoxville to Buffalo flights typically cost between $266 and $383 in October.The cheapest round-trip price found within the last 5 days was $287 on Delta (Oct 17-Oct 20).
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated August 27, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Food
7.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Food
7.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Food
7.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 27, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Knoxville to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on August 27, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Buffalo
Discover the top 3 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$159 | Average$300 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$372 | FlexibilityNo cancel fee | On-time63% |