$139+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Mar 15 — Mar 221
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/177:25 pm
TYS
- BUF
1 stop4h 17m
United Airlines
Thu 3/196:07 am
BUF
- TYS
1 stop4h 42m
United Airlines
Deal found 2/11![United Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/121:52 pm
TYS
- BUF
1 stop27h 49m
Multiple Airlines
Thu 3/1912:50 pm
BUF
- TYS
2 stops19h 18m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:30 am
TYS
- BUF
2 stops52h 35m
Multiple Airlines
Mon 3/211:37 am
BUF
- TYS
1 stop6h 54m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/145:00 pm
TYS
- BUF
1 stop6h 50m
American Airlines
Sat 3/217:02 pm
BUF
- TYS
1 stop4h 48m
American Airlines
Deal found 2/12![American Airlines logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1412:54 pm
TYS
- BUF
2 stops22h 56m
Multiple Airlines
Sat 3/2110:44 am
BUF
- TYS
1 stop12h 32m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:50 am
TYS
- BUF
1 stop3h 50m
Southwest
Thu 3/193:55 pm
BUF
- TYS
1 stop6h 15m
Southwest
Deal found 2/12![Southwest logo]()
$348
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:50 am
TYS
- BUF
2 stops7h 25m
Southwest
Sun 3/226:00 pm
BUF
- TYS
1 stop4h 00m
Southwest
Deal found 2/9![Southwest logo]()
$372
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1712:30 pm
TYS
- BUF
2 stops10h 10m
Southwest
Thu 3/1912:05 pm
BUF
- TYS
2 stops9h 10m
Southwest
Deal found 2/11![Southwest logo]()
$377
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:30 am
TYS
- BUF
2 stops7h 43m
United Airlines
Thu 7/166:00 am
BUF
- TYS
1 stop4h 41m
United Airlines
Deal found 2/11![United Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:12 am
TYS
- BUF
1 stop5h 07m
American Airlines
Sun 6/218:00 am
BUF
- TYS
1 stop4h 44m
American Airlines
Deal found 2/10![American Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:38 pm
TYS
- BUF
1 stop4h 11m
American Airlines
Sat 2/285:29 am
BUF
- TYS
1 stop5h 42m
American Airlines
Deal found 2/10![American Airlines logo]()
$417
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/177:25 pm
TYS
- BUF
1 stop4h 17m
United Airlines
Thu 3/196:07 am
BUF
- TYS
1 stop4h 42m
United Airlines
Deal found 2/11![United Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/121:52 pm
TYS
- BUF
1 stop27h 49m
Multiple Airlines
Thu 3/1912:50 pm
BUF
- TYS
2 stops19h 18m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$315
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/194:02 pm
TYS
- BUF
1 stop7h 38m
American Airlines
Sun 3/225:29 am
BUF
- TYS
1 stop5h 29m
American Airlines
Deal found 2/9![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:50 am
TYS
- BUF
1 stop3h 50m
Southwest
Thu 3/193:55 pm
BUF
- TYS
1 stop6h 15m
Southwest
Deal found 2/12![Southwest logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:30 am
TYS
- BUF
2 stops52h 35m
Multiple Airlines
Mon 3/211:37 am
BUF
- TYS
1 stop6h 54m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:41 pm
TYS
- BUF
1 stop5h 10m
American Airlines
Thu 7/165:13 am
BUF
- TYS
1 stop5h 35m
American Airlines
Deal found 2/11![American Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/145:00 pm
TYS
- BUF
1 stop6h 50m
American Airlines
Sat 3/217:02 pm
BUF
- TYS
1 stop4h 48m
American Airlines
Deal found 2/12![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:50 am
TYS
- BUF
2 stops7h 25m
Southwest
Sun 3/226:00 pm
BUF
- TYS
1 stop4h 00m
Southwest
Deal found 2/9![Southwest logo]()
$372
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1712:30 pm
TYS
- BUF
2 stops10h 10m
Southwest
Thu 3/1912:05 pm
BUF
- TYS
2 stops9h 10m
Southwest
Deal found 2/11![Southwest logo]()
$377
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:12 am
TYS
- BUF
1 stop5h 07m
American Airlines
Sun 6/218:00 am
BUF
- TYS
1 stop4h 44m
American Airlines
Deal found 2/10![American Airlines logo]()
$397
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated February 13, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated February 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:38 pm
TYS
- BUF
1 stop4h 11m
American Airlines
Sat 2/285:29 am
BUF
- TYS
1 stop5h 42m
American Airlines
Deal found 2/10![American Airlines logo]()
$417
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:30 am
TYS
- BUF
2 stops52h 35m
Multiple Airlines
Mon 3/211:37 am
BUF
- TYS
1 stop6h 54m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/121:52 pm
TYS
- BUF
1 stop27h 49m
Multiple Airlines
Thu 3/1912:50 pm
BUF
- TYS
2 stops19h 18m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$315
This Southwest deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:50 am
TYS
- BUF
1 stop3h 50m
Southwest
Thu 3/193:55 pm
BUF
- TYS
1 stop6h 15m
Southwest
Deal found 2/12![Southwest logo]()
$348
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/145:00 pm
TYS
- BUF
1 stop6h 50m
American Airlines
Sat 3/217:02 pm
BUF
- TYS
1 stop4h 48m
American Airlines
Deal found 2/12![American Airlines logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1412:54 pm
TYS
- BUF
2 stops22h 56m
Multiple Airlines
Sat 3/2110:44 am
BUF
- TYS
1 stop12h 32m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/177:25 pm
TYS
- BUF
1 stop4h 17m
United Airlines
Thu 3/196:07 am
BUF
- TYS
1 stop4h 42m
United Airlines
Deal found 2/11![United Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1712:30 pm
TYS
- BUF
2 stops10h 10m
Southwest
Thu 3/1912:05 pm
BUF
- TYS
2 stops9h 10m
Southwest
Deal found 2/11![Southwest logo]()
$377
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:50 am
TYS
- BUF
2 stops7h 25m
Southwest
Sun 3/226:00 pm
BUF
- TYS
1 stop4h 00m
Southwest
Deal found 2/9![Southwest logo]()
$372
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:24 pm
TYS
- BUF
1 stop5h 31m
Delta
Deal found 2/12![Delta logo]()
$139
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:00 am
TYS
- BUF
2 stops7h 14m
American Airlines
Deal found 2/12![American Airlines logo]()
$144
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:40 am
TYS
- BUF
1 stop4h 04m
Delta
Deal found 2/12![Delta logo]()
$149
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:52 pm
TYS
- BUF
1 stop6h 51m
United Airlines
Deal found 2/10![United Airlines logo]()
$169
This Southwest deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:30 am
TYS
- BUF
2 stops8h 45m
Southwest
Deal found 2/12![Southwest logo]()
$185
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:35 am
TYS
- BUF
2 stops10h 05m
Southwest
Deal found 2/10![Southwest logo]()
$194
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/137:00 am
TYS
- BUF
2 stops8h 50m
Southwest
Deal found 2/11![Southwest logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1211:55 am
TYS
- BUF
3 stops29h 46m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/114:25 pm
TYS
- BUF
3 stops19h 40m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:00 am
TYS
- BUF
3 stops28h 13m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/138:45 am
TYS
- BUF
3 stops28h 29m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$419
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $287 (United Airlines) |
One-way from | $139 (Delta) |
Popular in | January |
Cheapest in | March |
Average price | $353 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Knoxville
Fly to
Buffalo
Route
Depart
Return
Price
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 3/17
7:25 pm-11:42 pm
1 stop4h 17m
Buffalo
Thu 3/19
6:07 am-10:49 am
1 stop4h 42m
$287
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 3/12
1:52 pm-5:41 pm
1 stop27h 49m
Buffalo
Thu 3/19
12:50 pm-8:08 am
2 stops19h 18m
$315
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 2/26
6:30 am-11:05 am
2 stops52h 35m
Buffalo
Mon 3/2
11:37 am-6:31 pm
1 stop6h 54m
$325
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 3/19
4:02 pm-11:40 pm
1 stop7h 38m
Buffalo
Sun 3/22
5:29 am-10:58 am
1 stop5h 29m
$337
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 7/9
6:41 pm-11:51 pm
1 stop5h 10m
Buffalo
Thu 7/16
5:13 am-10:48 am
1 stop5h 35m
$337
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sat 3/14
5:00 pm-11:50 pm
1 stop6h 50m
Buffalo
Sat 3/21
7:02 pm-11:50 pm
1 stop4h 48m
$337
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 3/12
7:50 am-11:40 am
1 stop3h 50m
Buffalo
Thu 3/19
3:55 pm-10:10 pm
1 stop6h 15m
$348
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 3/19
7:50 am-3:15 pm
2 stops7h 25m
Buffalo
Sun 3/22
6:00 pm-10:00 pm
1 stop4h 00m
$372
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 3/17
12:30 pm-10:40 pm
2 stops10h 10m
Buffalo
Thu 3/19
12:05 pm-9:15 pm
2 stops9h 10m
$377
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 6/18
7:12 am-12:19 pm
1 stop5h 07m
Buffalo
Sun 6/21
8:00 am-12:44 pm
1 stop4h 44m
$397
Showing 1-10 of 19 results
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated February 13, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
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Knoxville and Buffalo flights
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Top 2 airlines flying from Knoxville to Buffalo
Discover the top 2 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$164 | Average$248 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$298 | FlexibilityNo cancel fee | On-time71% |