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$168+ Cheap flights from Knoxville to Buffalo (TYS - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Cheap flight deals from Knoxville to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$277
(Delta)

One-way from

$168
(Kiwi.com)

Popular in

May

Cheapest in

March

Average price

$283
Provider with most accurate pricing for Knoxville McGhee Tyson-Buffalo flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Buffalo flights.
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From Knoxville McGhee Tyson to Buffalo
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One-way flight from Knoxville McGhee Tyson to Buffalo
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Highest demand for flights based on searches. 3% potential increase in price ($10 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Knoxville to Buffalo

Cheapest flights from Knoxville to Buffalo
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/95:40 amTYS - BUF
1 stop5h 24mDelta
Sat 1/176:00 amBUF - TYS
1 stop6h 09mDelta
Deal found 11/2$277
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/99:40 amTYS - BUF
1 stop4h 42mUnited Airlines
Sat 1/179:55 amBUF - TYS
2 stops11h 07mUnited Airlines
Deal found 11/2$282
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/910:20 amTYS - BUF
2 stops6h 29mAmerican Airlines
Sat 1/179:41 amBUF - TYS
2 stops6h 36mAmerican Airlines
Deal found 11/2$357
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:26 pmTYS - BUF
1 stop5h 35mDelta
Sat 11/226:12 amBUF - TYS
1 stop5h 28mDelta
Deal found 11/2$417
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/188:26 amTYS - BUF
2 stops10h 20mUnited Airlines
Sat 11/227:30 pmBUF - TYS
1 stop4h 29mUnited Airlines
Deal found 11/2$422
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/183:17 pmTYS - BUF
2 stops7h 39mAmerican Airlines
Sat 11/223:27 pmBUF - TYS
2 stops7h 27mAmerican Airlines
Deal found 11/2$427
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:38 pmTYS - BUF
2 stops20h 09mMultiple Airlines
Sun 11/96:59 pmBUF - TYS
1 stop18h 58mMultiple Airlines
Deal found 11/3$598
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/268:04 pmTYS - BUF
1 stop4h 04mAmerican Airlines
Sat 11/296:10 amBUF - TYS
1 stop6h 33mAmerican Airlines
Deal found 11/2$604
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/35:44 amTYS - BUF
1 stop5h 17mDelta
Mon 11/106:12 amBUF - TYS
1 stop5h 33mDelta
Deal found 11/2$607
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:16 pmTYS - BUF
1 stop5h 20mAmerican Airlines
Mon 11/103:27 pmBUF - TYS
2 stops7h 24mAmerican Airlines
Deal found 11/2$612
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/69:50 amTYS - BUF
1 stop4h 30mUnited Airlines
Sun 11/95:40 pmBUF - TYS
1 stop5h 15mUnited Airlines
Deal found 11/3$647

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Knoxville

Fly to

Buffalo

Route

Depart

Return

Price

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 12/9

5:40 am-11:04 am

1 stop5h 24m

Buffalo

Sat 1/17

6:00 am-12:09 pm

1 stop6h 09m

$277

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 12/9

9:40 am-2:22 pm

1 stop4h 42m

Buffalo

Sat 1/17

9:55 am-9:02 pm

2 stops11h 07m

$282

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 12/9

10:20 am-4:49 pm

2 stops6h 29m

Buffalo

Sat 1/17

9:41 am-4:17 pm

2 stops6h 36m

$357

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 11/18

5:26 pm-11:01 pm

1 stop5h 35m

Buffalo

Sat 11/22

6:12 am-11:40 am

1 stop5h 28m

$417

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 11/18

8:26 am-6:46 pm

2 stops10h 20m

Buffalo

Sat 11/22

7:30 pm-11:59 pm

1 stop4h 29m

$422

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 11/18

3:17 pm-10:56 pm

2 stops7h 39m

Buffalo

Sat 11/22

3:27 pm-10:54 pm

2 stops7h 27m

$427

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 11/6

5:38 pm-1:47 pm

2 stops20h 09m

Buffalo

Sun 11/9

6:59 pm-1:57 pm

1 stop18h 58m

$598

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 11/26

8:04 pm-12:08 am

1 stop4h 04m

Buffalo

Sat 11/29

6:10 am-12:43 pm

1 stop6h 33m

$604

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 11/6

9:50 am-2:20 pm

1 stop4h 30m

Buffalo

Sun 11/9

5:40 pm-10:55 pm

1 stop5h 15m

$647

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 11/26

7:20 pm-9:59 am

2 stops14h 39m

Buffalo

Sat 11/29

7:30 pm-11:59 pm

1 stop4h 29m

$928

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 15 results
1
2

Compare providers for flights from Knoxville to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Buffalo

What is the cheapest month to book a flight from Knoxville to Buffalo?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $159). Flying from Knoxville to Buffalo in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to BUF?

Find hourly flight availability from Knoxville to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Buffalo in the afternoon. If you’re flexible enough to do this you can expect to save up to 30% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated November 3, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Overall

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Overall

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
8,002 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Overall

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Buffalo?

    Delta, United Airlines, and American Airlines can get you from Knoxville to Buffalo in just under 4h 42m. Your travel time can differ by up to 1h 47m. There are 567 mi between Knoxville and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Buffalo round-trip?

    Flying on Delta is currently your cheapest option to Buffalo, with prices starting at $232. Another option worth looking into is American Airlines, starting at $248 round trip. These flights start at 26% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to Buffalo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Buffalo.

  • Can I find deals for business class flights from Knoxville to Buffalo?

    Yes. Cheapflights offers flight deals from Knoxville to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Buffalo?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $159). Flying from Knoxville to Buffalo in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Buffalo

Discover the top 2 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$232Average$248FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$315FlexibilityNo cancel feeOn-time71%

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