$134+ Cheap flights from Knoxville to Buffalo (TYS - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Apr 1 — Apr 81
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Buffalo
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Cheapest flights from Knoxville to BuffaloExplore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 2, 2026.
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
TYS
- BUF
1 stop26h 29m
Multiple Airlines
Tue 4/71:02 pm
BUF
- TYS
2 stops21h 34m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$235
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:50 am
TYS
- BUF
1 stop3h 50m
Southwest
Tue 4/74:00 pm
BUF
- TYS
1 stop4h 50m
Southwest
Deal found 3/2![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:15 am
TYS
- BUF
1 stop4h 00m
Southwest
Mon 5/44:00 pm
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 3/1![Southwest logo]()
$298
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:20 pm
TYS
- BUF
1 stop4h 30m
United Airlines
Sun 4/126:09 am
BUF
- TYS
1 stop4h 41m
United Airlines
Deal found 3/1![United Airlines logo]()
$307
This United Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:40 am
TYS
- BUF
1 stop4h 37m
United Airlines
Thu 4/96:09 am
BUF
- TYS
1 stop4h 41m
United Airlines
Deal found 2/27![United Airlines logo]()
$326
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:00 am
TYS
- BUF
2 stops6h 58m
American Airlines
Sun 4/126:00 am
BUF
- TYS
1 stop5h 15m
American Airlines
Deal found 3/1![American Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:40 am
TYS
- BUF
1 stop8h 45m
Southwest
Tue 7/144:25 pm
BUF
- TYS
1 stop4h 50m
Southwest
Deal found 2/27![Southwest logo]()
$342
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/812:50 pm
TYS
- BUF
2 stops9h 25m
Southwest
Sun 4/1212:25 pm
BUF
- TYS
2 stops8h 40m
Southwest
Deal found 3/1![Southwest logo]()
$347
Best flights from Knoxville to BuffaloDiscover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 2, 2026.
Discover carefully curated flight deals from Knoxville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 2, 2026.
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:50 am
TYS
- BUF
1 stop3h 50m
Southwest
Tue 4/74:00 pm
BUF
- TYS
1 stop4h 50m
Southwest
Deal found 3/2![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:05 am
TYS
- BUF
2 stops7h 30m
Southwest
Mon 5/44:00 pm
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 3/1![Southwest logo]()
$303
This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:40 am
TYS
- BUF
1 stop8h 45m
Southwest
Tue 7/144:25 pm
BUF
- TYS
1 stop4h 50m
Southwest
Deal found 2/27![Southwest logo]()
$342
This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:30 am
TYS
- BUF
2 stops8h 45m
Southwest
Mon 4/63:55 pm
BUF
- TYS
1 stop6h 15m
Southwest
Deal found 2/27![Southwest logo]()
$362
This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:35 pm
TYS
- BUF
2 stops9h 00m
Southwest
Sun 6/216:00 pm
BUF
- TYS
1 stop4h 25m
Southwest
Deal found 2/27![Southwest logo]()
$362
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:45 am
TYS
- BUF
2 stops9h 30m
Southwest
Sun 6/76:00 pm
BUF
- TYS
1 stop4h 25m
Southwest
Deal found 3/2![Southwest logo]()
$392
This Southwest deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/37:50 am
TYS
- BUF
1 stop3h 50m
Southwest
Mon 4/65:55 pm
BUF
- TYS
1 stop4h 15m
Southwest
Deal found 2/28![Southwest logo]()
$417
Last-minute flights from Knoxville to BuffaloDiscover last-minute flight deals from Knoxville to Buffalo. Data last updated March 2, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Buffalo. Data last updated March 2, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
TYS
- BUF
1 stop26h 29m
Multiple Airlines
Tue 4/71:02 pm
BUF
- TYS
2 stops21h 34m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$235
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:50 am
TYS
- BUF
1 stop3h 50m
Southwest
Tue 4/74:00 pm
BUF
- TYS
1 stop4h 50m
Southwest
Deal found 3/2![Southwest logo]()
$277
This United Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:40 am
TYS
- BUF
1 stop4h 37m
United Airlines
Thu 4/96:09 am
BUF
- TYS
1 stop4h 41m
United Airlines
Deal found 2/27![United Airlines logo]()
$326
This Southwest deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:30 am
TYS
- BUF
2 stops8h 45m
Southwest
Mon 4/65:55 pm
BUF
- TYS
1 stop4h 15m
Southwest
Deal found 2/28![Southwest logo]()
$352
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:20 pm
TYS
- BUF
1 stop4h 30m
United Airlines
Sun 4/126:09 am
BUF
- TYS
1 stop4h 41m
United Airlines
Deal found 3/1![United Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:00 am
TYS
- BUF
2 stops6h 58m
American Airlines
Sun 4/126:00 am
BUF
- TYS
1 stop5h 15m
American Airlines
Deal found 3/1![American Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/812:50 pm
TYS
- BUF
2 stops9h 25m
Southwest
Sun 4/1212:25 pm
BUF
- TYS
2 stops8h 40m
Southwest
Deal found 3/1![Southwest logo]()
$347
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
TYS
- BUF
1 stop5h 58m
American Airlines
Sun 4/126:00 am
BUF
- TYS
1 stop5h 15m
American Airlines
Deal found 3/1![American Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:15 am
TYS
- BUF
1 stop4h 00m
Southwest
Mon 5/44:00 pm
BUF
- TYS
1 stop5h 15m
Southwest
Deal found 3/1![Southwest logo]()
$298
One-way flights from Knoxville to BuffaloSearch for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated March 2, 2026.
Search for one-way flight options from Knoxville to Buffalo. Find affordable one-way fares based on user searches. Data last updated March 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:27 am
TYS
- BUF
2 stops23h 56m
Multiple Airlines
Deal found 2/28![Multiple Airlines logo]()
$134
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:26 pm
TYS
- BUF
1 stop5h 13m
Delta
Deal found 2/27![Delta logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:24 pm
TYS
- BUF
2 stops41h 41m
Multiple Airlines
Deal found 2/27![Multiple Airlines logo]()
$248
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:40 am
TYS
- BUF
1 stop4h 04m
Delta
Deal found 2/27![Delta logo]()
$284
Find flight deals from Knoxville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $235 (Kiwi.com) |
One-way from | $134 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $243 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 2, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 4/1
7:50 am-11:40 am
1 stop3h 50m
Buffalo
Tue 4/7
4:00 pm-8:50 pm
1 stop4h 50m
$277
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Wed 4/29
7:05 am-2:35 pm
2 stops7h 30m
Buffalo
Mon 5/4
4:00 pm-9:15 pm
1 stop5h 15m
$303
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 7/10
6:40 am-3:25 pm
1 stop8h 45m
Buffalo
Tue 7/14
4:25 pm-9:15 pm
1 stop4h 50m
$342
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 4/2
6:30 am-3:15 pm
2 stops8h 45m
Buffalo
Mon 4/6
3:55 pm-10:10 pm
1 stop6h 15m
$362
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 6/18
12:35 pm-9:35 pm
2 stops9h 00m
Buffalo
Sun 6/21
6:00 pm-10:25 pm
1 stop4h 25m
$362
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Sun 5/31
7:45 am-5:15 pm
2 stops9h 30m
Buffalo
Sun 6/7
6:00 pm-10:25 pm
1 stop4h 25m
$392
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Fri 4/3
7:50 am-11:40 am
1 stop3h 50m
Buffalo
Mon 4/6
5:55 pm-10:10 pm
1 stop4h 15m
$417
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 4/30
11:27 am-11:23 am
2 stops23h 56m
$134
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Thu 4/30
5:26 pm-10:39 pm
1 stop5h 13m
$160
KnoxvilleBuffalo
TYS - BUF
TYSBUF
Knoxville McGhee Tyson
Tue 3/10
6:24 pm-12:05 pm
2 stops41h 41m
$248
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Buffalo in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
TYS-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Buffalo
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated March 2, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.9
Crew
8.5
Comfort
7.9
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Overall
7.9
Crew
8.5
Comfort
7.9
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Overall
7.9
Crew
8.5
Comfort
7.9
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
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Other flights to Buffalo
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Knoxville and Buffalo flights
Browse other Knoxville and Buffalo flight options. Last updated on March 2, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on March 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Buffalo
Discover the top 2 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$198 | Average$308 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$232 | Average$248 | FlexibilityNo cancel fee | On-timeN/A |