HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Brussels

$400+ Cheap flights from Des Moines (DSM) to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BRU
Apr 7 — Apr 141
Tue 4/7
Tue 4/14
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Brussels with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Brussels

Cheapest flights from Des Moines to Brussels
Explore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.

This Expedia deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:16 pm
DSM
-
BRU
2 stops17h 59m
British Airways
Tue 4/2110:55 am
BRU
-
DSM
2 stops19h 54m
British Airways
Deal found 3/3$629
This Flighttix deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:20 am
DSM
-
BRU
2 stops17h 50m
Air Canada
Tue 4/219:55 am
BRU
-
DSM
2 stops18h 37m
Air Canada
Deal found 3/4$636
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/63:15 pm
DSM
-
BRU
2 stops15h 00m
United Airlines
Wed 12/910:10 am
BRU
-
DSM
1 stop18h 07m
United Airlines
Deal found 3/6$637
This Bravofly deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:16 pm
DSM
-
BRU
2 stops13h 59m
Lufthansa
Mon 4/277:30 pm
BRU
-
DSM
2 stops34h 47m
Lufthansa
Deal found 3/5$638
This Flighttix deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:16 pm
DSM
-
BRU
2 stops29h 34m
Multiple Airlines
Tue 4/2110:15 am
BRU
-
DSM
1 stop18h 17m
Multiple Airlines
Deal found 3/4$643
This Ticket deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ticket is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:20 am
DSM
-
BRU
2 stops17h 50m
Air Canada
Mon 4/279:55 am
BRU
-
DSM
2 stops35h 30m
Air Canada
Deal found 3/6$645
This Flighttix deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:04 am
DSM
-
BRU
2 stops16h 06m
Air Canada
Tue 4/289:55 am
BRU
-
DSM
2 stops18h 37m
Air Canada
Deal found 3/7$646
This Bravofly deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:16 pm
DSM
-
BRU
2 stops13h 59m
Lufthansa
Tue 4/288:30 am
BRU
-
DSM
2 stops20h 02m
Lufthansa
Deal found 3/7$654
This Booking.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/143:21 pm
DSM
-
BRU
2 stops32h 49m
Air Canada
Tue 4/289:55 am
BRU
-
DSM
2 stops33h 34m
Air Canada
Deal found 3/6$658
This KLM deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:31 pm
DSM
-
BRU
1 stop30h 09m
KLM
Tue 4/289:45 am
BRU
-
DSM
1 stop19h 49m
KLM
Deal found 3/7$659

Find flight deals from Des Moines to Brussels

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Brussels (BR1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 8, 2026.

Round-trip from

$629
(Expedia)

One-way from

$400
(oojo)
From Des Moines to Brussels
Search Deals
One-way flight from Des Moines to Brussels
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
Use the filters below to find and compare flights from Des Moines to Brussels that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 4/21

6:31 pm-7:40 am

1 stop30h 09m

Brussels Bruxelles-National

Tue 4/28

9:45 am-10:34 pm

1 stop19h 49m

$659
Quickest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 4/21

3:21 pm-1:15 pm

2 stops14h 54m

Brussels Bruxelles-National

Tue 4/28

10:15 am-11:17 pm

1 stop20h 02m

$671

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sun 4/19

12:06 pm-2:10 pm

2 stops19h 04m

Brussels Bruxelles-National

Sun 4/26

11:20 am-10:26 am

2 stops30h 06m

$676

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 4/21

10:56 am-2:40 pm

2 stops20h 44m

Brussels Bruxelles-National

Tue 4/28

9:45 am-5:45 pm

1 stop15h 00m

$683

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 4/17

5:00 am-6:20 pm

2 stops30h 20m

Brussels Bruxelles-National

Fri 4/24

6:30 am-6:35 pm

2 stops19h 05m

$715
Cheapest one-way

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 4/21

7:16 pm-7:10 am

2 stops28h 54m

$531

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 5/2

7:05 pm-9:00 am

1 stop30h 55m

$579

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 4/18

2:44 pm-7:40 am

1 stop33h 56m

$612

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 4/21

2:44 pm-7:40 am

1 stop33h 56m

$615
Quickest one-way

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 4/17

11:51 am-7:40 am

1 stop12h 49m

$657

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/6

Sorted by cheapest first

Best time to book a flight from Des Moines to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Brussels
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated March 8, 2026.
See what other customers who have flown with United Airlines from Des Moines to Brussels have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,405 reviews

Entertainment

7.1

Crew

8.1

Comfort

7.3

Food

6.6

Overall

7.4

Boarding

7.7

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,405 reviews
United Airlines
7.4
Good
9,405 reviews

Entertainment

7.1

Crew

8.1

Comfort

7.3

Food

6.6

Overall

7.4

Boarding

7.7

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Brussels?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Brussels. 1 airline have flights from Des Moines to Brussels on a regular basis. Booking flights from Des Moines to Brussels should not be difficult; the airport handles an average of 0 outbound flights to Brussels per day.

  • How long is the flight from Des Moines to Brussels?

    There are many flights that can get you from Des Moines to Brussels in 14h 54m. Fly via KLM or United Airlines to get the fastest option. The distance from Des Moines to Brussels is about 4377 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Des Moines to Brussels round-trip?

    According to our current data, United Airlines ($707), offers the cheapest pricing from Des Moines to Brussels.

  • Can I find deals for flights from Des Moines to Brussels that include hotel bookings?

    Yes. In addition to deals on Des Moines to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Brussels.

  • Can I find deals for business class flights from Des Moines to Brussels?

    Yes. Cheapflights offers flight deals from Des Moines to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Des Moines to Brussels

Discover the top airline that operate flights from Des Moines to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$707Average$1,444FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.