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$251+ Cheap flights from Des Moines (DSM) to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BRU
Feb 7 — Feb 141
Sat 2/7
Sat 2/14
1 adult, Economy
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Cheap flight deals from Des Moines to Brussels

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Brussels (BR1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 8, 2026.

Round-trip from

$469
(Ticket)

One-way from

$251
(oojo)
From Des Moines to Brussels
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One-way flight from Des Moines to Brussels
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Find flight deals from Des Moines to Brussels

Cheapest flights from Des Moines to Brussels
Explore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This Ticket deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ticket is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/2210:40 amDSM - BRU
2 stops13h 55mKLM
Sun 3/110:45 amBRU - DSM
2 stops17h 04mKLM
Deal found 1/8$469
This Flighttix deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/223:24 pmDSM - BRU
2 stops33h 26mMultiple Airlines
Sun 3/19:30 amBRU - DSM
2 stops19h 11mMultiple Airlines
Deal found 1/8$479
This oojo deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/221:38 pmDSM - BRU
2 stops20h 02mBritish Airways
Sun 3/111:20 amBRU - DSM
2 stops19h 20mBritish Airways
Deal found 1/7$484
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/208:00 amDSM - BRU
2 stops22h 15mUnited Airlines
Fri 2/2710:00 amBRU - DSM
2 stops42h 41mUnited Airlines
Deal found 1/8$485
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/223:24 pmDSM - BRU
1 stop10h 31mUnited Airlines
Sun 3/19:30 amBRU - DSM
2 stops19h 11mUnited Airlines
Deal found 1/8$506
This United Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/213:24 pmDSM - BRU
1 stop10h 31mUnited Airlines
Sat 2/2810:00 amBRU - DSM
2 stops35h 27mUnited Airlines
Deal found 1/6$512

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Des Moines to Brussels that are best for you.

Fly from

Des Moines

Fly to

Brussels

Route

Depart

Return

Price

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 2/20

8:00 am-1:15 pm

2 stops22h 15m

Brussels Bruxelles-National

Fri 2/27

10:00 am-9:41 pm

2 stops42h 41m

$485

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sun 2/22

11:17 am-6:25 pm

2 stops24h 08m

Brussels Bruxelles-National

Sun 3/1

7:10 pm-11:48 pm

2 stops35h 38m

$491

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sun 2/22

3:24 pm-8:55 am

1 stop10h 31m

Brussels Bruxelles-National

Sun 3/1

9:30 am-9:41 pm

2 stops19h 11m

$506

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 5/2

8:01 pm-2:15 pm

2 stops35h 14m

$251

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 5/2

5:15 pm-7:40 am

1 stop31h 25m

$262

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 5/2

8:00 am-7:45 am

3 stops16h 45m

$507

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/7

Best time to book a flight from Des Moines to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Brussels
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated January 8, 2026.
See what other customers who have flown with United Airlines from Des Moines to Brussels have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,139 reviews

Boarding

7.7

Crew

8.1

Food

6.6

Entertainment

7.1

Comfort

7.3

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

IAD - TYS

It was a short flight on a small express plane, so no time for amenities. Quickly on, quickly off. No complaints.
United Airlines
7.4
Good
9,139 reviews
United Airlines
7.4
Good
9,139 reviews

Boarding

7.7

Crew

8.1

Food

6.6

Entertainment

7.1

Comfort

7.3

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

IAD - TYS

It was a short flight on a small express plane, so no time for amenities. Quickly on, quickly off. No complaints.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Brussels?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Brussels. 1 airline have flights from Des Moines to Brussels on a regular basis. Booking flights from Des Moines to Brussels should not be difficult; the airport handles an average of 0 outbound flights to Brussels per day.

  • How long is the flight from Des Moines to Brussels?

    There are many flights that can get you from Des Moines to Brussels in 22h 15m. Fly via United Airlines to get the fastest option. The distance from Des Moines to Brussels is about 4377 mi.

  • What is the cheapest airline to fly from Des Moines to Brussels round-trip?

    According to our current data, United Airlines ($707), offers the cheapest pricing from Des Moines to Brussels.

  • Can I find deals for flights from Des Moines to Brussels that include hotel bookings?

    Yes. In addition to deals on Des Moines to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Brussels.

  • Can I find deals for business class flights from Des Moines to Brussels?

    Yes. Cheapflights offers flight deals from Des Moines to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Des Moines to Brussels

Discover the top airline that operate flights from Des Moines to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$707Average$1,444FlexibilityNo cancel feeOn-time69%

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