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$545+ Cheap flights from Des Moines (DSM) to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BRU
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Des Moines to Brussels

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Brussels (BR1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$554
(lastminute.com)

One-way from

$545
(KLM)
From Des Moines to Brussels
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One-way flight from Des Moines to Brussels
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Find flight deals from Des Moines to Brussels

Cheapest flights from Des Moines to Brussels
Explore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This lastminute.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:13 pmDSM - BRU
2 stops37h 27mScandinavian Airlines
Thu 11/63:10 pmBRU - DSM
2 stops38h 20mScandinavian Airlines
Deal found 9/15$554
This Finnair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:04 amDSM - BRU
2 stops35h 26mMultiple Airlines
Thu 11/67:10 pmBRU - DSM
2 stops34h 49mMultiple Airlines
Deal found 9/15$675
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3010:00 amDSM - BRU
2 stops22h 15mDelta
Thu 11/611:00 amBRU - DSM
2 stops30h 05mDelta
Deal found 9/15$676
This Finnair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:04 amDSM - BRU
2 stops31h 21mMultiple Airlines
Fri 11/77:05 amBRU - DSM
2 stops22h 54mMultiple Airlines
Deal found 9/16$787
This lol.travel deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:15 pmDSM - BRU
2 stops15h 20mUnited Airlines
Fri 11/710:10 amBRU - DSM
1 stop18h 22mUnited Airlines
Deal found 9/16$862

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Brussels that are best for you.

Fly from

Des Moines

Fly to

Brussels

Route

Depart

Return

Price

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

5:04 am-10:30 pm

2 stops35h 26m

Brussels Bruxelles-National

Thu 11/6

7:10 pm-10:59 pm

2 stops34h 49m

$675

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

10:00 am-2:15 pm

2 stops22h 15m

Brussels Bruxelles-National

Thu 11/6

11:00 am-10:05 am

2 stops30h 05m

$676

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 10/31

5:04 am-6:25 pm

2 stops31h 21m

Brussels Bruxelles-National

Fri 11/7

7:05 am-10:59 pm

2 stops22h 54m

$787

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 10/31

12:30 pm-7:35 am

2 stops13h 05m

$545

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

2:40 pm-10:10 am

2 stops13h 30m

$584

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

11:26 am-7:55 am

1 stop14h 29m

$618

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 10/31

8:02 am-7:55 am

1 stop17h 53m

$618

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

1:05 pm-1:15 pm

3 stops18h 10m

$624

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 10/31

1:05 pm-1:15 pm

3 stops18h 10m

$625

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 9/20

5:12 pm-8:40 am

2 stops32h 28m

$994

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 11 results
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Best time to book a flight from Des Moines to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Brussels
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated September 17, 2025.
See what other customers who have flown with United Airlines from Des Moines to Brussels have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,926 reviews

Entertainment

7.1

Overall

7.4

Boarding

7.7

Comfort

7.3

Crew

8.1

Food

6.6

Reviews

1 / 20
10.0
Excellent

Julia,Sep 2025

BUF - DEN

The staff were amazing, from check in to boarding and on the flight. The range of entertainment options were really good as well.
United Airlines
7.4
Good
8,926 reviews
United Airlines
7.4
Good
8,926 reviews

Entertainment

7.1

Overall

7.4

Boarding

7.7

Comfort

7.3

Crew

8.1

Food

6.6

Reviews

1 / 20
10.0
Excellent

Julia,Sep 2025

BUF - DEN

The staff were amazing, from check in to boarding and on the flight. The range of entertainment options were really good as well.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Brussels?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Brussels. 1 airline have flights from Des Moines to Brussels on a regular basis. Booking flights from Des Moines to Brussels should not be difficult; the airport handles an average of 0 outbound flights to Brussels per day.

  • How long is the flight from Des Moines to Brussels?

    There are many flights that can get you from Des Moines to Brussels in 22h 15m. Fly via Delta to get the fastest option. The distance from Des Moines to Brussels is about 4377 mi.

  • What is the cheapest airline to fly from Des Moines to Brussels round-trip?

    According to our current data, United Airlines ($705), offers the cheapest pricing from Des Moines to Brussels.

  • Can I find deals for flights from Des Moines to Brussels that include hotel bookings?

    Yes. In addition to deals on Des Moines to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Brussels.

  • Can I find deals for business class flights from Des Moines to Brussels?

    Yes. Cheapflights offers flight deals from Des Moines to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Brussels?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Brussels (average of $614). Flying from Des Moines to Brussels in June is currently the most expensive (average of $1,077). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to Bruxelles-National flights
Omaha to Bruxelles-National flights

Top airline flying from Des Moines to Brussels

Discover the top airline that operate flights from Des Moines to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$705Average$1,141FlexibilityNo cancel feeOn-time69%

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