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$452+ Cheap flights from Des Moines (DSM) to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BRU
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Find flight deals from Des Moines to Brussels

Cheapest flights from Des Moines to Brussels
Explore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:45 amDSM - BRU
2 stops24h 30mUnited Airlines
Mon 12/292:25 pmBRU - DSM
2 stops34h 40mUnited Airlines
Deal found 11/2$658
This Billigflug deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1611:35 amDSM - BRU
2 stops18h 40mMultiple Airlines
Tue 12/237:10 pmBRU - DSM
2 stops33h 30mMultiple Airlines
Deal found 11/1$719
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/168:00 amDSM - BRU
2 stops22h 15mUnited Airlines
Tue 12/237:00 amBRU - DSM
2 stops34h 50mUnited Airlines
Deal found 11/1$738
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1511:35 amDSM - BRU
2 stops18h 40mUnited Airlines
Mon 12/224:55 pmBRU - DSM
2 stops34h 35mUnited Airlines
Deal found 11/1$741
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:15 amDSM - BRU
2 stops22h 00mUnited Airlines
Sun 12/2810:10 amBRU - DSM
1 stop31h 40mUnited Airlines
Deal found 11/2$799
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/178:00 amDSM - BRU
2 stops22h 15mUnited Airlines
Wed 12/2411:55 amBRU - DSM
2 stops33h 38mUnited Airlines
Deal found 11/2$803
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/173:17 pmDSM - BRU
2 stops14h 58mMultiple Airlines
Wed 12/2410:30 amBRU - DSM
2 stops15h 59mMultiple Airlines
Deal found 11/1$804

Cheap flight deals from Des Moines to Brussels

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Brussels (BR1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 3, 2025.

Round-trip from

$633
(United Airlines)

One-way from

$452
(Thrive Travel)
From Des Moines to Brussels
Search Deals
One-way flight from Des Moines to Brussels
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Des Moines to Brussels that are best for you.

Fly from

Des Moines

Fly to

Brussels

Route

Depart

Return

Price

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 3/27

8:00 am-7:15 am

2 stops17h 15m

Brussels Bruxelles-National

Tue 3/31

10:00 am-2:11 pm

2 stops35h 11m

$638

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 3/27

11:04 am-8:00 am

1 stop14h 56m

Brussels Bruxelles-National

Tue 3/31

10:45 am-10:28 pm

1 stop18h 43m

$656

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 12/13

5:45 am-1:15 pm

2 stops24h 30m

Brussels Bruxelles-National

Mon 12/29

2:25 pm-6:05 pm

2 stops34h 40m

$658

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 12/16

8:00 am-1:15 pm

2 stops22h 15m

Brussels Bruxelles-National

Tue 12/23

7:00 am-10:50 am

2 stops34h 50m

$738

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 12/15

11:35 am-1:15 pm

2 stops18h 40m

Brussels Bruxelles-National

Mon 12/22

4:55 pm-8:30 pm

2 stops34h 35m

$741

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 5/2

11:30 am-9:00 am

1 stop14h 30m

$452

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 5/2

6:45 pm-8:05 am

2 stops30h 20m

$456

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 12/16

6:50 pm-1:15 pm

2 stops35h 25m

$569

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 12/16

11:35 am-1:15 pm

3 stops18h 40m

$630

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/1

Best time to book a flight from Des Moines to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Brussels
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated November 3, 2025.
See what other customers who have flown with United Airlines from Des Moines to Brussels have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,997 reviews

Entertainment

7.1

Crew

8.1

Boarding

7.7

Food

6.6

Comfort

7.3

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
8,997 reviews
United Airlines
7.4
Good
8,997 reviews

Entertainment

7.1

Crew

8.1

Boarding

7.7

Food

6.6

Comfort

7.3

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Brussels?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Brussels. 1 airline have flights from Des Moines to Brussels on a regular basis. Booking flights from Des Moines to Brussels should not be difficult; the airport handles an average of 0 outbound flights to Brussels per day.

  • How long is the flight from Des Moines to Brussels?

    There are many flights that can get you from Des Moines to Brussels in 14h 56m. Fly via United Airlines or Delta to get the fastest option. The distance from Des Moines to Brussels is about 4377 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Des Moines to Brussels round-trip?

    According to our current data, United Airlines ($794), offers the cheapest pricing from Des Moines to Brussels.

  • Can I find deals for flights from Des Moines to Brussels that include hotel bookings?

    Yes. In addition to deals on Des Moines to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Brussels.

  • Can I find deals for business class flights from Des Moines to Brussels?

    Yes. Cheapflights offers flight deals from Des Moines to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to Bruxelles-National flights
Omaha to Bruxelles-National flights

Top airline flying from Des Moines to Brussels

Discover the top airline that operate flights from Des Moines to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$794Average$1,421FlexibilityNo cancel feeOn-time69%

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