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Biloxi

$229+ Cheap flights from Knoxville (TYS) to Biloxi, MS

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Knoxville to Biloxi

Keep the following information in mind while searching for Knoxville to Biloxi flight deals. Data was last updated September 11, 2025.

Round-trip from

$239
(Delta)

Popular in

July

Cheapest in

June

Average price

$398
From Knoxville McGhee Tyson to Biloxi
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($14 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Biloxi

Cheapest flights from Knoxville to Biloxi
Explore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/75:44 amTYS - GPT
1 stop4h 32mDelta
Tue 10/146:05 pmGPT - TYS
1 stop4h 02mDelta
Deal found 9/9$229
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/247:45 pmTYS - GPT
1 stop3h 57mAmerican Airlines
Sun 9/286:34 pmGPT - TYS
1 stop4h 33mAmerican Airlines
Deal found 9/9$239
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/167:45 pmTYS - GPT
1 stop3h 57mAmerican Airlines
Fri 9/265:32 pmGPT - TYS
1 stop4h 31mAmerican Airlines
Deal found 9/9$254
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/277:45 pmTYS - GPT
1 stop3h 57mAmerican Airlines
Wed 10/15:32 pmGPT - TYS
1 stop4h 31mAmerican Airlines
Deal found 9/8$294
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/238:23 amTYS - GPT
1 stop6h 08mAmerican Airlines
Thu 9/256:34 pmGPT - TYS
1 stop4h 33mAmerican Airlines
Deal found 9/8$417
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/279:30 amTYS - GPT
1 stop7h 42mUnited Airlines
Wed 10/15:25 pmGPT - TYS
2 stops15h 45mUnited Airlines
Deal found 9/8$423
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/118:36 pmTYS - GPT
1 stop4h 29mAmerican Airlines
Sun 9/1412:52 pmGPT - TYS
1 stop5h 54mAmerican Airlines
Deal found 9/9$427
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:05 pmTYS - GPT
1 stop27h 05mMultiple Airlines
Mon 12/296:51 pmGPT - TYS
1 stop15h 15mMultiple Airlines
Deal found 9/9$455
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/247:20 amTYS - GPT
1 stop7h 53mUnited Airlines
Sun 9/285:25 pmGPT - TYS
2 stops15h 45mUnited Airlines
Deal found 9/9$512
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/259:30 amTYS - GPT
1 stop4h 55mUnited Airlines
Mon 9/295:25 pmGPT - TYS
2 stops28h 25mUnited Airlines
Deal found 9/10$514

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Knoxville to Biloxi that are best for you.

Fly from

Knoxville

Fly to

Biloxi

Route

Depart

Return

Price

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 10/7

5:44 am-9:16 am

1 stop4h 32m

Gulfport Biloxi Regional

Tue 10/14

6:05 pm-11:07 pm

1 stop4h 02m

$229

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Thu 9/25

5:45 am-9:19 am

1 stop4h 34m

Gulfport Biloxi Regional

Mon 9/29

6:04 pm-11:44 pm

1 stop4h 40m

$239

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Sat 9/27

7:45 pm-10:42 pm

1 stop3h 57m

Gulfport Biloxi Regional

Wed 10/1

5:32 pm-11:03 pm

1 stop4h 31m

$294

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 9/23

8:23 am-1:31 pm

1 stop6h 08m

Gulfport Biloxi Regional

Thu 9/25

6:34 pm-12:07 am

1 stop4h 33m

$417

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Sat 9/27

9:30 am-4:12 pm

1 stop7h 42m

Gulfport Biloxi Regional

Wed 10/1

5:25 pm-10:10 am

2 stops15h 45m

$423

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Wed 12/24

5:05 pm-7:10 pm

1 stop27h 05m

Gulfport Biloxi Regional

Mon 12/29

6:51 pm-11:06 am

1 stop15h 15m

$455

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Wed 9/24

7:20 am-2:13 pm

1 stop7h 53m

Gulfport Biloxi Regional

Sun 9/28

5:25 pm-10:10 am

2 stops15h 45m

$512

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Thu 9/25

9:30 am-1:25 pm

1 stop4h 55m

Gulfport Biloxi Regional

Mon 9/29

5:25 pm-10:50 pm

2 stops28h 25m

$514

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 9/16

12:00 pm-4:05 pm

1 stop5h 05m

$289

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fri 10/3

11:18 am-5:00 pm

1 stop6h 42m

$445

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 11 results
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Best time to book a flight from Knoxville to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Biloxi

What is the cheapest month to book a flight from Knoxville to Biloxi?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Biloxi (average of $256). Flying from Knoxville to Biloxi in April is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to B1L?

Find hourly flight availability from Knoxville to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Knoxville to Biloxi, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Knoxville to Biloxi?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Biloxi. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Biloxi flight should consider departing on Thursday mornings when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Biloxi by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Biloxi?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Biloxi. You should not have trouble finding flights to Biloxi from McGhee Tyson; the airport handles an average of 0 outbound flights to Biloxi per day. You should also have plenty of airline options to choose from since 4 airlines have flights from the Knoxville airport to Biloxi. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Biloxi?

    A quick flight from Knoxville to Biloxi can take about 3h 57m. Delta provides one of the quickest options available for as low as $294. The distance from Knoxville to Biloxi is about 474 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Biloxi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Biloxi.

  • Can I find deals for business class flights from Knoxville to Biloxi?

    Yes. Cheapflights offers flight deals from Knoxville to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Biloxi?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Biloxi (average of $256). Flying from Knoxville to Biloxi in April is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Knoxville to Biloxi

Discover the top 4 airlines that operate flights from Knoxville to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$71Average$88FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$223Average$438FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$228Average$363FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$429FlexibilityNo cancel feeOn-timeN/A

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