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Biloxi

$269+ Cheap flights from Knoxville (TYS) to Biloxi, MS

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Apr 11 — Apr 181
Sat 4/11
Sat 4/18
1 adult, Economy
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Cheap flight deals from Knoxville to Biloxi

Cheapest flights from Knoxville to Biloxi
Explore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.

This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:30 am
TYS
-
GPT
1 stop5h 05m
Delta
Tue 10/276:00 pm
GPT
-
TYS
1 stop4h 46m
Delta
Deal found 3/8$269
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:40 am
TYS
-
GPT
1 stop4h 10m
Delta
Mon 3/305:57 pm
GPT
-
TYS
1 stop5h 00m
Delta
Deal found 3/10$318
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:40 am
TYS
-
GPT
1 stop4h 10m
Delta
Mon 3/305:57 pm
GPT
-
TYS
1 stop5h 00m
Delta
Deal found 3/10$338
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:40 am
TYS
-
GPT
1 stop4h 10m
Delta
Mon 4/135:55 pm
GPT
-
TYS
1 stop4h 59m
Delta
Deal found 3/9$343
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:05 am
TYS
-
GPT
1 stop7h 16m
United Airlines
Wed 4/155:15 pm
GPT
-
TYS
1 stop5h 26m
United Airlines
Deal found 3/11$347
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:40 am
TYS
-
GPT
1 stop4h 10m
Delta
Sat 4/43:00 pm
GPT
-
TYS
1 stop4h 20m
Delta
Deal found 3/9$374
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:20 pm
TYS
-
GPT
1 stop3h 46m
Delta
Thu 8/276:00 pm
GPT
-
TYS
1 stop4h 47m
Delta
Deal found 3/8$397
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:45 am
TYS
-
GPT
1 stop4h 36m
Delta
Fri 6/126:00 pm
GPT
-
TYS
1 stop4h 46m
Delta
Deal found 3/9$417
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:07 pm
TYS
-
GPT
1 stop6h 54m
American Airlines
Sat 6/136:38 pm
GPT
-
TYS
1 stop4h 09m
American Airlines
Deal found 3/9$455
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:15 am
TYS
-
GPT
1 stop7h 11m
United Airlines
Wed 8/262:00 pm
GPT
-
TYS
2 stops29h 48m
United Airlines
Deal found 3/8$468
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:05 am
TYS
-
GPT
1 stop13h 48m
United Airlines
Sat 4/254:26 pm
GPT
-
TYS
1 stop6h 15m
United Airlines
Deal found 3/11$473

Find flight deals from Knoxville to Biloxi

Keep the following information in mind while searching for Knoxville to Biloxi flight deals. Data was last updated March 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$268
(Kiwi.com)

Popular in

March

Cheapest in

June

Average price

$734
Provider with most accurate pricing for Knoxville McGhee Tyson-Gulfport Biloxi Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Gulfport Biloxi Regional flights.
Search Deals
From Knoxville McGhee Tyson to Biloxi
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($98 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Knoxville to Biloxi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 3/31

5:40 am-8:50 am

1 stop4h 10m

Gulfport Biloxi Regional

Sat 4/4

3:00 pm-8:20 pm

1 stop4h 20m

$374

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 6/8

7:20 pm-10:07 pm

1 stop3h 47m

Gulfport Biloxi Regional

Fri 6/12

6:00 pm-11:46 pm

1 stop4h 46m

$417

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Sat 6/6

5:45 am-9:21 am

1 stop4h 36m

Gulfport Biloxi Regional

Sun 6/14

6:00 pm-11:46 pm

1 stop4h 46m

$417

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 6/8

7:20 pm-10:07 pm

1 stop3h 47m

Gulfport Biloxi Regional

Sun 6/14

6:00 pm-11:46 pm

1 stop4h 46m

$417

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 8/24

7:20 pm-10:06 pm

1 stop3h 46m

Gulfport Biloxi Regional

Thu 8/27

6:00 pm-11:47 pm

1 stop4h 47m

$428

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Sat 8/22

7:15 am-1:26 pm

1 stop7h 11m

Gulfport Biloxi Regional

Wed 8/26

2:00 pm-10:08 am

2 stops19h 08m

$468

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 3/23

6:38 pm-10:15 pm

1 stop4h 37m

Gulfport Biloxi Regional

Fri 3/27

5:57 pm-11:57 pm

1 stop5h 00m

$488
Cheapest one-way
Quickest one-way

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 3/16

5:47 pm-11:57 pm

1 stop7h 10m

$359

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 3/16

5:43 pm-4:06 pm

2 stops23h 23m

$697

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Sorted by cheapest first

Best time to book a flight from Knoxville to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Biloxi

What is the cheapest month to book a flight from Knoxville to Biloxi?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Biloxi (average of $130). Flying from Knoxville to Biloxi in February is currently the most expensive (average of $277). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated March 12, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Biloxi by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,286 reviews

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,286 reviews
Delta
7.9
Good
8,286 reviews

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,435 reviews
Delta
7.9
Good
8,286 reviews

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Biloxi?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Biloxi. You should not have trouble finding flights to Biloxi from McGhee Tyson; the airport handles an average of 0 outbound flights to Biloxi per day. You should also have plenty of airline options to choose from since 4 airlines have flights from the Knoxville airport to Biloxi. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Biloxi?

    A quick flight from Knoxville to Biloxi can take about 4h 10m. Delta provides one of the quickest options available for as low as $318. The distance from Knoxville to Biloxi is about 474 mi.

  • Can I find deals for flights from Knoxville to Biloxi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Biloxi.

  • Can I find deals for business class flights from Knoxville to Biloxi?

    Yes. Cheapflights offers flight deals from Knoxville to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Biloxi?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Biloxi (average of $130). Flying from Knoxville to Biloxi in February is currently the most expensive (average of $277). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Knoxville to Biloxi

Discover the top 4 airlines that operate flights from Knoxville to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$71Average$88FlexibilityNo cancel feeOn-time88%
DeltaCheapest$209Average$382FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$362FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$286Average$376FlexibilityNo cancel feeOn-time63%

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