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Biloxi

$187+ Cheap flights from Knoxville (TYS) to Biloxi, MS

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Jan 15 — Jan 221
Thu 1/15
Thu 1/22
1 adult, Economy
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Cheap flight deals from Knoxville to Biloxi

Cheapest flights from Knoxville to Biloxi
Explore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:44 pmTYS - GPT
2 stops26h 26mMultiple Airlines
Sun 12/287:50 pmGPT - TYS
1 stop13h 25mMultiple Airlines
Deal found 12/14$330
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/254:54 pmTYS - GPT
1 stop5h 46mDelta
Sun 12/286:00 amGPT - TYS
1 stop4h 09mDelta
Deal found 12/16$427
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/177:23 pmTYS - GPT
1 stop4h 10mAmerican Airlines
Mon 12/2912:35 pmGPT - TYS
1 stop6h 06mAmerican Airlines
Deal found 12/13$502
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:35 amTYS - GPT
1 stop5h 51mDelta
Sun 12/286:00 amGPT - TYS
1 stop4h 09mDelta
Deal found 12/15$548
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amTYS - GPT
1 stop7h 22mUnited Airlines
Sun 12/285:15 pmGPT - TYS
2 stops28h 24mUnited Airlines
Deal found 12/16$553
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:00 amTYS - GPT
1 stop6h 01mAmerican Airlines
Sun 12/284:48 pmGPT - TYS
1 stop4h 10mAmerican Airlines
Deal found 12/14$556
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/216:00 amTYS - GPT
1 stop4h 59mDelta
Wed 12/245:21 pmGPT - TYS
1 stop5h 12mDelta
Deal found 12/15$566
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:45 amTYS - GPT
2 stops31h 37mUnited Airlines
Sun 12/285:15 pmGPT - TYS
2 stops28h 24mUnited Airlines
Deal found 12/14$718
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:45 amTYS - GPT
2 stops15h 52mUnited Airlines
Sun 12/285:15 pmGPT - TYS
2 stops28h 24mUnited Airlines
Deal found 12/15$728
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/215:40 pmTYS - GPT
1 stop7h 32mAmerican Airlines
Wed 12/242:32 pmGPT - TYS
2 stops21h 20mAmerican Airlines
Deal found 12/15$745

Find flight deals from Knoxville to Biloxi

Keep the following information in mind while searching for Knoxville to Biloxi flight deals. Data was last updated December 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$314
(Delta)

One-way from

$187
(Kiwi.com)

Popular in

July

Cheapest in

June

Average price

$288
Provider with most accurate pricing for Knoxville McGhee Tyson-Gulfport Biloxi Regional flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Gulfport Biloxi Regional flights.
Search Deals
From Knoxville McGhee Tyson to Biloxi
Search Deals
One-way flight from Knoxville McGhee Tyson to Biloxi
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($21 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Knoxville to Biloxi that are best for you.

Fly from

Knoxville

Fly to

Biloxi

Route

Depart

Return

Price

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Sat 1/10

6:59 am-1:22 pm

1 stop7h 23m

Gulfport Biloxi Regional

Tue 1/13

4:42 pm-11:44 pm

1 stop6h 02m

$344

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Thu 12/25

4:54 pm-9:40 pm

1 stop5h 46m

Gulfport Biloxi Regional

Sun 12/28

6:00 am-11:09 am

1 stop4h 09m

$427

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Sat 2/7

7:11 pm-11:08 pm

1 stop4h 57m

Gulfport Biloxi Regional

Mon 2/16

4:36 pm-11:54 pm

1 stop6h 18m

$427

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 12/23

8:35 am-1:26 pm

1 stop5h 51m

Gulfport Biloxi Regional

Sun 12/28

6:00 am-11:09 am

1 stop4h 09m

$548

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Sat 12/20

6:13 pm-7:15 pm

1 stop26h 02m

$187

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 1/6

5:40 am-9:33 am

1 stop4h 53m

$189

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 1/12

9:05 am-3:58 pm

1 stop7h 53m

$199

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 1/12

6:09 pm-9:53 pm

1 stop4h 44m

$199

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fri 12/19

7:00 am-12:16 pm

1 stop6h 16m

$339

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fri 12/19

7:00 am-1:22 pm

1 stop7h 22m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 11 results
1
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Best time to book a flight from Knoxville to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Biloxi

What is the cheapest month to book a flight from Knoxville to Biloxi?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Biloxi (average of $130). Flying from Knoxville to Biloxi in December is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to B1L?

Find hourly flight availability from Knoxville to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 16, 2025.

When flying from Knoxville to Biloxi, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 21% versus a flight in the morning.

What is the cheapest day to fly from Knoxville to Biloxi?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Biloxi. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Biloxi flight should consider departing on Wednesday mornings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated December 16, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Biloxi by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,010 reviews

Food

7.3

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,010 reviews
Delta
7.9
Good
8,010 reviews

Food

7.3

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,048 reviews
Delta
7.9
Good
8,010 reviews

Food

7.3

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Biloxi?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Biloxi. You should not have trouble finding flights to Biloxi from McGhee Tyson; the airport handles an average of 0 outbound flights to Biloxi per day. You should also have plenty of airline options to choose from since 4 airlines have flights from the Knoxville airport to Biloxi. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Biloxi?

    A quick flight from Knoxville to Biloxi can take about 4h 57m. United Airlines provides one of the quickest options available for as low as $427. The distance from Knoxville to Biloxi is about 474 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Biloxi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Biloxi.

  • Can I find deals for business class flights from Knoxville to Biloxi?

    Yes. Cheapflights offers flight deals from Knoxville to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Biloxi?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Biloxi (average of $130). Flying from Knoxville to Biloxi in December is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 4 airlines flying from Knoxville to Biloxi

Discover the top 4 airlines that operate flights from Knoxville to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$72Average$88FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$228Average$354FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$331FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$253Average$438FlexibilityNo cancel feeOn-time69%

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