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Biloxi

$198+ Cheap flights from Knoxville (TYS) to Biloxi, MS

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Knoxville to Biloxi

Cheapest flights from Knoxville to Biloxi
Explore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:35 am
TYS
-
GPT
1 stop4h 49m
Delta
Wed 3/115:57 pm
GPT
-
TYS
1 stop5h 00m
Delta
Deal found 1/26$275
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:35 am
TYS
-
GPT
1 stop4h 49m
Delta
Tue 3/36:00 am
GPT
-
TYS
1 stop4h 08m
Delta
Deal found 1/25$276
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/35:17 pm
TYS
-
GPT
1 stop6h 24m
American Airlines
Tue 2/105:29 pm
GPT
-
TYS
1 stop4h 25m
American Airlines
Deal found 1/27$279
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/65:14 pm
TYS
-
GPT
1 stop6h 27m
American Airlines
Sun 2/86:32 am
GPT
-
TYS
1 stop4h 15m
American Airlines
Deal found 1/27$299
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/275:17 pm
TYS
-
GPT
1 stop6h 24m
American Airlines
Mon 2/25:29 pm
GPT
-
TYS
1 stop4h 25m
American Airlines
Deal found 1/26$309
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/105:17 pm
TYS
-
GPT
1 stop6h 24m
American Airlines
Sat 2/144:29 pm
GPT
-
TYS
1 stop4h 26m
American Airlines
Deal found 1/26$347
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/309:05 am
TYS
-
GPT
1 stop7h 53m
United Airlines
Sun 2/17:00 am
GPT
-
TYS
1 stop5h 50m
United Airlines
Deal found 1/27$364
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:35 pm
TYS
-
GPT
2 stops18h 25m
Multiple Airlines
Sun 4/267:20 pm
GPT
-
TYS
1 stop21h 10m
Multiple Airlines
Deal found 1/26$368
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:25 pm
TYS
-
GPT
2 stops27h 15m
Multiple Airlines
Sun 4/267:20 pm
GPT
-
TYS
1 stop21h 10m
Multiple Airlines
Deal found 1/26$369
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/59:13 pm
TYS
-
GPT
1 stop12h 47m
Multiple Airlines
Thu 3/127:20 pm
GPT
-
TYS
1 stop20h 29m
Multiple Airlines
Deal found 1/26$388
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:35 am
TYS
-
GPT
1 stop4h 49m
Delta
Tue 3/175:57 pm
GPT
-
TYS
1 stop5h 00m
Delta
Deal found 1/26$397
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/43:54 pm
TYS
-
GPT
2 stops27h 46m
Multiple Airlines
Thu 3/127:20 pm
GPT
-
TYS
1 stop20h 29m
Multiple Airlines
Deal found 1/26$420

Find flight deals from Knoxville to Biloxi

Keep the following information in mind while searching for Knoxville to Biloxi flight deals. Data was last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$275
(Delta)

One-way from

$198
(Delta)

Popular in

December

Cheapest in

June

Average price

$309
Provider with most accurate pricing for Knoxville McGhee Tyson-Gulfport Biloxi Regional flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Gulfport Biloxi Regional flights.
Search Deals
From Knoxville McGhee Tyson to Biloxi
Search Deals
One-way flight from Knoxville McGhee Tyson to Biloxi
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($55 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Knoxville to Biloxi that are best for you.

Fly from

Knoxville

Fly to

Biloxi

Route

Depart

Return

Price

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 3/3

5:35 am-9:24 am

1 stop4h 49m

Gulfport Biloxi Regional

Wed 3/11

5:57 pm-11:57 pm

1 stop5h 00m

$275

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 2/24

5:35 am-9:24 am

1 stop4h 49m

Gulfport Biloxi Regional

Tue 3/3

6:00 am-11:08 am

1 stop4h 08m

$276

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 2/10

5:17 pm-10:41 pm

1 stop6h 24m

Gulfport Biloxi Regional

Sat 2/14

4:29 pm-9:55 pm

1 stop4h 26m

$347

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Wed 4/22

4:25 pm-6:40 pm

2 stops27h 15m

Gulfport Biloxi Regional

Sun 4/26

7:20 pm-5:30 pm

1 stop21h 10m

$369

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Thu 3/5

9:13 pm-9:00 am

1 stop12h 47m

Gulfport Biloxi Regional

Thu 3/12

7:20 pm-4:49 pm

1 stop20h 29m

$388

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Thu 3/5

5:35 am-9:24 am

1 stop4h 49m

Gulfport Biloxi Regional

Tue 3/17

5:57 pm-11:57 pm

1 stop5h 00m

$397

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Sun 2/22

6:41 pm-9:54 pm

1 stop4h 13m

Gulfport Biloxi Regional

Sun 3/1

6:00 pm-11:52 pm

1 stop4h 52m

$439

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Wed 3/4

5:35 am-9:24 am

1 stop4h 49m

Gulfport Biloxi Regional

Thu 3/12

9:48 am-4:06 pm

1 stop5h 18m

$439

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 3/3

9:10 am-1:20 pm

1 stop5h 10m

Gulfport Biloxi Regional

Tue 3/10

2:00 pm-1:18 pm

2 stops22h 18m

$473

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fri 4/24

5:54 pm-10:13 pm

1 stop5h 19m

Gulfport Biloxi Regional

Sun 4/26

6:00 am-5:08 pm

1 stop10h 08m

$533

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 23 results
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Best time to book a flight from Knoxville to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Biloxi

What is the cheapest month to book a flight from Knoxville to Biloxi?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Biloxi (average of $130). Flying from Knoxville to Biloxi in January is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated January 28, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Biloxi by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,123 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,123 reviews
Delta
7.9
Good
8,123 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,201 reviews
Delta
7.9
Good
8,123 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Biloxi?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Biloxi. You should not have trouble finding flights to Biloxi from McGhee Tyson; the airport handles an average of 0 outbound flights to Biloxi per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Biloxi. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Biloxi?

    A quick flight from Knoxville to Biloxi can take about 4h 49m. Delta provides one of the quickest options available for as low as $275. The distance from Knoxville to Biloxi is about 474 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Biloxi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Biloxi.

  • Can I find deals for business class flights from Knoxville to Biloxi?

    Yes. Cheapflights offers flight deals from Knoxville to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Biloxi?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Biloxi (average of $130). Flying from Knoxville to Biloxi in January is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Knoxville to Biloxi

Discover the top 3 airlines that operate flights from Knoxville to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$72Average$88FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$228Average$352FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$351FlexibilityNo cancel feeOn-timeN/A

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