It’s generally more expensive to depart on a Wednesday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.
It’s typically best to fly out from Des Moines to Belgrade in the morning. Doing so could potentially save you 17% on the flight price compared to flying in the afternoon, which is usually more expensive.
When booking a flight from Des Moines to Belgrade, you may want to consider flying on Delta, KLM or Lufthansa as they are the most popular for this route.