Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Durham to Tupelo as you normally would.
Tupelo Lemons Municipal (TUP) is the airport you will fly into if you book a flight from Durham to Tupelo. You should not have trouble finding flights to Lemons Municipal from Durham; the airport handles an average of 0 inbound flights from Durham per day. You should also have plenty of airline options to choose from since 0 airlines have flights to the Tupelo airport from Durham. It is only a 3.6 mi journey from Lemons Municipal (TUP) to Tupelo’s city center.