How long is the flight from Missouri to Syracuse?

There are many flights that can get you from Missouri to Syracuse in 4h 21m. Fly via United Airlines, American Airlines, or Delta to get the fastest option. The distance between Missouri and Syracuse is about 801 mi. This flight may include one or multiple stops.

What are the cheapest airlines to fly from Missouri to Syracuse one-way?

One-way options have recently been found by users for as low as $63 on American Airlines. Other airlines that offer cheap prices include Frontier from $64 and Delta from $155 one-way.

In terms of precipitation, rainfall in Syracuse ranges from 2.1 - 3.8 inches per month. July is typically the wettest month, when rainfall can reach 3.8 in. February is typically the driest time to visit Syracuse when rainfall is around 2.1 in.

If weather is an important factor for your trip to Syracuse, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What are the most popular routes from Missouri to Syracuse?

While some choose either Kansas City - Syracuse Hancock Intl or Springfield-Branson - Syracuse Hancock Intl, Lambert-St Louis - Syracuse Hancock Intl is the most popular route from Missouri to Syracuse.

What airport do you fly into for flights to Syracuse from Missouri?

Located just 4.8 mi from the city center, Syracuse Hancock Intl (SYR) is the airport most travelers will use when flying to Syracuse from Missouri.

Can I find deals for flights from Missouri to Syracuse that include hotel bookings?

Yes. In addition to deals on Missouri to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Syracuse?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Syracuse.

Can I find deals for business class flights from Missouri to Syracuse?

Yes. Cheapflights offers flight deals from Missouri to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$128+ Flights from Missouri to Syracuse

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Cheap flight deals from Missouri to Syracuse

Cheapest flights from Missouri to Syracuse
Explore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Sat 12/135:00 pmSTL - SYR

1 stop5h 11mDelta

Wed 12/176:00 amSYR - STL

1 stop5h 45mDelta

Deal found 12/6

$339

Wed 12/245:55 pmSTL - SYR

1 stop4h 21mDelta

Fri 1/26:00 amSYR - STL

1 stop4h 24mDelta

Deal found 12/8

$364

Fri 12/195:16 pmSTL - SYR

1 stop5h 13mAmerican Airlines

Tue 12/237:47 pmSYR - STL

1 stop13h 48mAmerican Airlines

Deal found 12/7

$396

Fri 12/125:12 pmMCI - SYR

1 stop5h 21mDelta

Mon 12/1512:18 pmSYR - MCI

1 stop6h 12mDelta

Deal found 12/7

$409

Fri 12/129:08 amMCI - SYR

1 stop7h 08mAmerican Airlines

Mon 12/155:12 amSYR - MCI

2 stops8h 33mAmerican Airlines

Deal found 12/7

$414

Mon 12/225:59 pmSTL - SYR

1 stop4h 18mDelta

Sat 12/2712:19 pmSYR - STL

1 stop6h 11mDelta

Deal found 12/8

$459

Sat 12/139:00 amCOU - SYR

2 stops13h 00mUnited Airlines

Wed 12/175:23 pmSYR - COU

1 stop4h 59mUnited Airlines

Deal found 12/6

$476

Tue 12/235:59 pmSTL - SYR

1 stop4h 18mDelta

Fri 1/26:00 amSYR - STL

1 stop4h 24mDelta

Deal found 12/8

$478

Wed 12/245:55 pmSTL - SYR

1 stop4h 21mDelta

Sat 12/2712:19 pmSYR - STL

1 stop6h 11mDelta

Deal found 12/8

$490

Mon 12/153:22 pmSTL - SYR

1 stop7h 17mAmerican Airlines

Mon 12/225:32 pmSYR - STL

1 stop6h 12mAmerican Airlines

Deal found 12/8

$495

Wed 12/246:00 amSTL - SYR

2 stops8h 11mAmerican Airlines

Fri 1/27:26 pmSYR - STL

1 stop5h 29mAmerican Airlines

Deal found 12/8

$503

Sat 12/206:15 pmMCI - SYR

1 stop22h 35mMultiple Airlines

Tue 12/237:58 pmSYR - MCI

2 stops22h 12mMultiple Airlines

Deal found 12/7

$508

Best flights from Missouri to Syracuse
Discover carefully curated flight deals from Missouri to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 8, 2025.

Fri 1/231:42 pmMCI - SYR

1 stop8h 31mUnited Airlines

Mon 1/267:45 amSYR - MCI

1 stop9h 23mUnited Airlines

Deal found 12/8

$259

Sat 1/176:00 amMCI - SYR

1 stop4h 26mAmerican Airlines

Mon 1/196:29 pmSYR - MCI

1 stop6h 06mAmerican Airlines

Deal found 12/7

$259

Wed 12/245:55 pmSTL - SYR

1 stop4h 21mDelta

Fri 1/26:00 amSYR - STL

1 stop4h 24mDelta

Deal found 12/8

$364

Sat 1/1711:29 amMCI - SYR

2 stops10h 56mUnited Airlines

Mon 1/197:45 amSYR - MCI

1 stop9h 23mUnited Airlines

Deal found 12/7

$264

Sat 2/1411:15 amCOU - SYR

2 stops11h 06mUnited Airlines

Wed 2/1810:23 amSYR - COU

2 stops11h 17mUnited Airlines

Deal found 12/6

$319

Fri 1/307:45 amSGF - SYR

1 stop7h 30mUnited Airlines

Tue 2/34:57 pmSYR - SGF

1 stop6h 01mUnited Airlines

Deal found 12/6

$325

Fri 12/195:16 pmSTL - SYR

1 stop5h 13mAmerican Airlines

Tue 12/237:47 pmSYR - STL

1 stop13h 48mAmerican Airlines

Deal found 12/7

$396

Thu 1/88:00 amMCI - SYR

1 stop7h 15mUnited Airlines

Mon 1/124:57 pmSYR - MCI

1 stop6h 02mUnited Airlines

Deal found 12/6

$329

Mon 12/225:59 pmSTL - SYR

1 stop4h 18mDelta

Sat 12/2712:19 pmSYR - STL

1 stop6h 11mDelta

Deal found 12/8

$459

Sat 5/22:30 pmJLN - SYR

1 stop7h 53mUnited Airlines

Wed 5/66:07 amSYR - JLN

2 stops8h 30mUnited Airlines

Deal found 12/6

$344

Tue 12/235:59 pmSTL - SYR

1 stop4h 18mDelta

Fri 1/26:00 amSYR - STL

1 stop4h 24mDelta

Deal found 12/8

$478

Wed 12/245:55 pmSTL - SYR

1 stop4h 21mDelta

Sat 12/2712:19 pmSYR - STL

1 stop6h 11mDelta

Deal found 12/8

$490

Mon 12/295:58 pmSGF - SYR

1 stop4h 40mAmerican Airlines

Wed 12/3111:38 amSYR - SGF

1 stop6h 50mAmerican Airlines

Deal found 12/6

$541

Thu 1/812:44 pmSTL - SYR

2 stops9h 41mUnited Airlines

Mon 1/1210:19 amSYR - STL

1 stop24h 54mUnited Airlines

Deal found 12/6

$446

Tue 12/2310:17 amCOU - SYR

1 stop6h 13mAmerican Airlines

Sat 12/276:06 pmSYR - COU

1 stop4h 53mAmerican Airlines

Deal found 12/7

$617

Mon 12/2911:24 amSGF - SYR

1 stop8h 45mUnited Airlines

Wed 12/315:30 amSYR - SGF

2 stops10h 08mUnited Airlines

Deal found 12/6

$606

Tue 12/236:34 pmCOU - SYR

2 stops23h 13mUnited Airlines

Sat 12/276:15 amSYR - COU

1 stop9h 20mUnited Airlines

Deal found 12/7

$725

Fri 12/266:20 pmSGF - SYR

1 stop25h 49mUnited Airlines

Sun 12/287:30 pmSYR - SGF

2 stops23h 57mUnited Airlines

Deal found 12/6

$812

Last-minute flights from Missouri to Syracuse
Discover last-minute flight deals from Missouri to Syracuse. Data last updated December 8, 2025 and is based on user searches.

Fri 12/125:12 pmMCI - SYR

1 stop5h 21mDelta

Mon 12/1512:18 pmSYR - MCI

1 stop6h 12mDelta

Deal found 12/7

$409

Fri 12/129:08 amMCI - SYR

1 stop7h 08mAmerican Airlines

Mon 12/155:12 amSYR - MCI

2 stops8h 33mAmerican Airlines

Deal found 12/7

$414

Sat 12/135:00 pmSTL - SYR

1 stop5h 11mDelta

Wed 12/176:00 amSYR - STL

1 stop5h 45mDelta

Deal found 12/6

$339

Fri 12/195:16 pmSTL - SYR

1 stop5h 13mAmerican Airlines

Tue 12/237:47 pmSYR - STL

1 stop13h 48mAmerican Airlines

Deal found 12/7

$396

Mon 12/225:59 pmSTL - SYR

1 stop4h 18mDelta

Sat 12/2712:19 pmSYR - STL

1 stop6h 11mDelta

Deal found 12/8

$459

Wed 12/245:55 pmSTL - SYR

1 stop4h 21mDelta

Fri 1/26:00 amSYR - STL

1 stop4h 24mDelta

Deal found 12/8

$364

Thu 1/88:00 amMCI - SYR

1 stop7h 15mUnited Airlines

Mon 1/124:57 pmSYR - MCI

1 stop6h 02mUnited Airlines

Deal found 12/6

$329

Thu 1/812:44 pmSTL - SYR

2 stops9h 41mUnited Airlines

Mon 1/1210:19 amSYR - STL

1 stop24h 54mUnited Airlines

Deal found 12/6

$446

Sat 1/176:00 amMCI - SYR

1 stop4h 26mAmerican Airlines

Mon 1/196:29 pmSYR - MCI

1 stop6h 06mAmerican Airlines

Deal found 12/7

$259

Sat 1/1711:29 amMCI - SYR

2 stops10h 56mUnited Airlines

Mon 1/197:45 amSYR - MCI

1 stop9h 23mUnited Airlines

Deal found 12/7

$264

Fri 1/2311:29 amMCI - SYR

2 stops10h 56mUnited Airlines

Mon 1/262:42 pmSYR - MCI

2 stops9h 48mUnited Airlines

Deal found 12/8

$269

Fri 1/307:45 amSGF - SYR

1 stop7h 30mUnited Airlines

Tue 2/34:57 pmSYR - SGF

1 stop6h 01mUnited Airlines

Deal found 12/6

$325

One-way flights from Missouri to Syracuse
Search for one-way flight options from Missouri to Syracuse. Find affordable one-way fares based on user searches. Data last updated December 8, 2025.

Wed 2/115:44 pmSTL - SYR

2 stops21h 38mFrontier

Deal found 12/7

$128

Wed 2/117:43 pmSTL - SYR

3 stops44h 56mMultiple Airlines

Deal found 12/7

$156

Mon 12/159:54 amSTL - SYR

1 stop6h 56mFrontier

Deal found 12/8

$163

Sun 1/1811:26 amMCI - SYR

2 stops21h 10mMultiple Airlines

Deal found 12/7

$171

Mon 12/159:54 amSTL - SYR

2 stops25h 11mMultiple Airlines

Deal found 12/8

$192

Wed 2/1111:05 amSTL - SYR

1 stop11h 49mAmerican Airlines

Deal found 12/7

$219

Thu 1/221:35 pmSTL - SYR

1 stop9h 19mAmerican Airlines

Deal found 12/8

$222

Mon 12/296:15 pmMCI - SYR

1 stop15h 30mMultiple Airlines

Deal found 12/8

$228

Thu 1/225:42 pmSTL - SYR

3 stops24h 14mMultiple Airlines

Deal found 12/8

$240

Sun 12/148:45 pmMCI - SYR

3 stops38h 20mMultiple Airlines

Deal found 12/8

$262

Sun 1/1810:58 amMCI - SYR

1 stop5h 40mAmerican Airlines

Deal found 12/8

$271

Thu 1/2211:20 amSTL - SYR

2 stops24h 50mUnited Airlines

Deal found 12/8

$290

Find flight deals from Missouri to Syracuse

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$259 (American Airlines)
One-way from	$128 (Kiwi.com)
Popular in	December
Cheapest in	January
Average price	$448

Provider with most accurate pricing for Lambert-St Louis-Syracuse Hancock Intl flight deals.

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Provider most trusted by Cheapflights users for Lambert-St Louis-Syracuse Hancock Intl flights.

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From Missouri to Syracuse Hancock Intl

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One-way flight from Missouri to Syracuse Hancock Intl

Search Deals

Highest demand for flights based on searches. 2% potential increase in price ($8 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Fri 1/23

1:42 pm-11:13 pm

1 stop8h 31m

Syracuse Hancock Intl

Mon 1/26

7:45 am-4:08 pm

1 stop9h 23m

$259

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Sat 1/17

6:00 am-11:26 am

1 stop4h 26m

Syracuse Hancock Intl

Mon 1/19

6:29 pm-11:35 pm

1 stop6h 06m

$259

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Sat 1/17

11:29 am-11:25 pm

2 stops10h 56m

Syracuse Hancock Intl

Mon 1/19

7:45 am-4:08 pm

1 stop9h 23m

$264

ColumbiaSyracuse

COU - SYR

COUSYR

Columbia Regional

Sat 2/14

11:15 am-11:21 pm

2 stops11h 06m

Syracuse Hancock Intl

Wed 2/18

10:23 am-8:40 pm

2 stops11h 17m

$319

SpringfieldSyracuse

SGF - SYR

SGFSYR

Springfield-Branson

Fri 1/30

7:45 am-4:15 pm

1 stop7h 30m

Syracuse Hancock Intl

Tue 2/3

4:57 pm-9:58 pm

1 stop6h 01m

$325

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Thu 1/8

8:00 am-4:15 pm

1 stop7h 15m

Syracuse Hancock Intl

Mon 1/12

4:57 pm-9:59 pm

1 stop6h 02m

$329

JoplinSyracuse

JLN - SYR

JLNSYR

Joplin

Sat 5/2

2:30 pm-11:23 pm

1 stop7h 53m

Syracuse Hancock Intl

Wed 5/6

6:07 am-1:37 pm

2 stops8h 30m

$344

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Wed 12/24

5:55 pm-11:16 pm

1 stop4h 21m

Syracuse Hancock Intl

Fri 1/2

6:00 am-9:24 am

1 stop4h 24m

$364

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Fri 12/19

5:16 pm-11:29 pm

1 stop5h 13m

Syracuse Hancock Intl

Tue 12/23

7:47 pm-8:35 am

1 stop13h 48m

$396

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Thu 1/8

12:44 pm-11:25 pm

2 stops9h 41m

Syracuse Hancock Intl

Mon 1/12

10:19 am-10:13 am

1 stop24h 54m

$446

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/7

Showing 1-10 of 30 results

Best time to book a flight from Missouri to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Syracuse

What is the cheapest month to book a flight from Missouri to Syracuse?

Currently, July is the cheapest month in which you can book a flight from Missouri to Syracuse (average of $155). Flying from Missouri to Syracuse in December is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SYR?

When flying from Missouri to Syracuse, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 26% versus a flight in the morning.

Related info for your journey

What airport do you fly into for flights to Syracuse from Missouri?
Located just 4.8 mi from the city center, Syracuse Hancock Intl (SYR) is the airport most travelers will use when flying to Syracuse from Missouri.
How long is the flight from Missouri to Syracuse?
There are many flights that can get you from Missouri to Syracuse in 4h 21m. Fly via United Airlines, American Airlines, or Delta to get the fastest option. The distance between Missouri and Syracuse is about 801 mi. This flight may include one or multiple stops.
What are the cheapest airlines to fly from Missouri to Syracuse one-way?
One-way options have recently been found by users for as low as $63 on American Airlines. Other airlines that offer cheap prices include Frontier from $64 and Delta from $155 one-way.
What are the most popular routes from Missouri to Syracuse?
While some choose either Kansas City - Syracuse Hancock Intl or Springfield-Branson - Syracuse Hancock Intl, Lambert-St Louis - Syracuse Hancock Intl is the most popular route from Missouri to Syracuse.
Can I find deals for flights from Missouri to Syracuse that include hotel bookings?
Yes. In addition to deals on Missouri to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Syracuse?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Syracuse.
Can I find deals for business class flights from Missouri to Syracuse?
Yes. Cheapflights offers flight deals from Missouri to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Syracuse?
Currently, July is the cheapest month in which you can book a flight from Missouri to Syracuse (average of $155). Flying from Missouri to Syracuse in December is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Missouri to Syracuse

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$198	Average$408	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$236	Average$327	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$268	Average$367	FlexibilityNo cancel fee	On-time69%

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$128+ Cheap flights from Missouri to Syracuse (SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/11. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Missouri to Syracuse

Cheapest flights from Missouri to SyracuseExplore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Explore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Find flight deals from Missouri to Syracuse

Keep the following information in mind while searching for Missouri to Syracuse flight deals. Data was last updated December 8, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Syracuse that are best for you.

Best time to book a flight from Missouri to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Syracuse

What is the cheapest month to book a flight from Missouri to Syracuse?

What is the cheapest time of day to fly from MO to SYR?

Find hourly flight availability from Missouri to Syracuse. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 8, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Syracuse from Missouri?

How long is the flight from Missouri to Syracuse?

What are the cheapest airlines to fly from Missouri to Syracuse one-way?

What are the most popular routes from Missouri to Syracuse?

Can I find deals for flights from Missouri to Syracuse that include hotel bookings?

How can I find direct flights from Missouri to Syracuse?

Can I find deals for business class flights from Missouri to Syracuse?

What is the cheapest month to book a flight from Missouri to Syracuse?

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Alternative routes for Missouri to Syracuse

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Top 3 airlines flying from Missouri to Syracuse

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Cheapest flights from Missouri to Syracuse
Explore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.