What are the cheapest airlines to fly from Missouri to Syracuse one-way?

One-way options have recently been found by users for as low as $119 on Frontier. Other airlines that offer cheap prices include Delta from $153 and American Airlines from $262 one-way.

In terms of precipitation, rainfall in Syracuse ranges from 2.1 - 3.8 inches per month. July is typically the wettest month, when rainfall can reach 3.8 in. February is typically the driest time to visit Syracuse when rainfall is around 2.1 in.

If weather is an important factor for your trip to Syracuse, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What are the most popular routes from Missouri to Syracuse?

While some choose either Kansas City - Syracuse Hancock Intl or Springfield-Branson - Syracuse Hancock Intl, Lambert-St Louis - Syracuse Hancock Intl is the most popular route from Missouri to Syracuse.

What are the most popular airlines that fly from Missouri to Syracuse?

When booking a flight from Missouri to Syracuse, you may want to consider flying on American Airlines, Delta or United Airlines as they are the most popular for this route.

How far in advance should I book a flight from Missouri to Syracuse?

Travelers have found it’s best to book a flight 28 days in advance to save up to 80% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 28 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Missouri to Syracuse 1-2 weeks in advance for as low as $257, or $358 for flights within the next 24 hours.

What is the cheapest month to fly from Missouri to Syracuse?

Due to multiple factors, expect to potentially pay more when booking in February. For low rates, April can be a great choice for travel to Syracuse. Flights to Syracuse from Missouri in April are about $368 on average during April, but can be found for as low as $198.

What airport do you fly into for flights to Syracuse from Missouri?

Located just 4.8 mi from the city center, Syracuse Hancock Intl (SYR) is the airport most travelers will use when flying to Syracuse from Missouri.

Can I find deals for flights from Missouri to Syracuse that include hotel bookings?

Yes. In addition to deals on Missouri to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Syracuse?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Syracuse.

Can I find deals for business class flights from Missouri to Syracuse?

Yes. Cheapflights offers flight deals from Missouri to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$119+ Cheap Flights from Missouri to Syracuse

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Cheap flight deals from Missouri to Syracuse

Round-trip from	$249 (Delta)
One-way from	$119 (FlightHub)
Popular in	February
Cheapest in	April
Average price	$328

From Missouri to Syracuse Hancock Intl

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One-way flight from Missouri to Syracuse Hancock Intl

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Highest demand for flights based on searches. 5% potential increase in price ($21 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).

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Average for round-trip flights in August 2025

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Find flight deals from Missouri to Syracuse

Cheapest flights from Missouri to Syracuse
Explore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Thu 8/212:02 pmSTL - SYR

1 stop18h 26mFrontier

Sat 8/231:48 pmSYR - STL

1 stop24h 19mFrontier

Deal found 8/13

$237

Tue 9/95:25 pmSTL - SYR

1 stop4h 22mDelta

Wed 9/175:55 amSYR - STL

1 stop7h 26mDelta

Deal found 8/14

$249

Tue 9/23:10 pmSTL - SYR

1 stop6h 58mDelta

Sat 9/62:15 pmSYR - STL

1 stop5h 52mDelta

Deal found 8/14

$254

Thu 10/24:00 pmSTL - SYR

1 stop18h 22mFrontier

Thu 10/912:16 pmSYR - STL

1 stop23h 21mFrontier

Deal found 8/13

$257

Tue 9/26:02 amSTL - SYR

2 stops7h 11mAmerican Airlines

Sat 9/612:01 pmSYR - STL

1 stop5h 14mAmerican Airlines

Deal found 8/14

$259

Wed 9/174:06 pmMCI - SYR

1 stop6h 53mDelta

Sat 9/205:55 amSYR - MCI

1 stop5h 28mDelta

Deal found 8/14

$259

Wed 9/1710:28 amMCI - SYR

1 stop5h 41mAmerican Airlines

Sat 9/206:10 amSYR - MCI

2 stops9h 03mAmerican Airlines

Deal found 8/14

$264

Thu 10/235:30 amSTL - SYR

1 stop4h 18mAmerican Airlines

Sun 10/268:06 pmSYR - STL

1 stop13h 03mAmerican Airlines

Deal found 8/14

$269

Fri 10/246:08 pmSTL - SYR

1 stop4h 30mAmerican Airlines

Sun 10/267:40 amSYR - STL

1 stop7h 04mAmerican Airlines

Deal found 8/14

$273

Mon 12/225:32 amMCI - SYR

2 stops7h 10mAmerican Airlines

Wed 12/314:43 pmSYR - MCI

1 stop6h 20mAmerican Airlines

Deal found 8/13

$279

Fri 8/298:05 amJLN - SYR

2 stops9h 45mUnited Airlines

Tue 9/25:43 pmSYR - JLN

1 stop7h 00mUnited Airlines

Deal found 8/14

$290

Sat 9/274:10 pmSTL - SYR

1 stop7h 23mDelta

Sun 9/285:55 amSYR - STL

1 stop5h 04mDelta

Deal found 8/14

$294

Best flights from Missouri to Syracuse
Discover carefully curated flight deals from Missouri to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2025.

Tue 9/99:16 amSTL - SYR

1 stop7h 03mDelta

Wed 9/1712:15 pmSYR - STL

1 stop7h 50mDelta

Deal found 8/13

$249

Tue 9/96:00 pmSTL - SYR

1 stop4h 40mAmerican Airlines

Wed 9/176:47 pmSYR - STL

1 stop5h 20mAmerican Airlines

Deal found 8/13

$249

Fri 8/298:05 amJLN - SYR

2 stops9h 45mUnited Airlines

Tue 9/25:43 pmSYR - JLN

1 stop7h 00mUnited Airlines

Deal found 8/14

$290

Wed 10/156:00 pmSTL - SYR

1 stop4h 04mDelta

Sat 10/182:17 pmSYR - STL

1 stop4h 45mDelta

Deal found 8/13

$249

Sat 12/65:58 amSTL - SYR

2 stops7h 01mAmerican Airlines

Mon 12/87:40 amSYR - STL

1 stop7h 55mAmerican Airlines

Deal found 8/12

$254

Fri 10/245:15 pmSTL - SYR

1 stop6h 05mDelta

Sun 10/266:00 amSYR - STL

1 stop4h 37mDelta

Deal found 8/13

$249

Thu 9/186:30 pmMCI - SYR

1 stop4h 59mAmerican Airlines

Sun 9/217:38 pmSYR - MCI

1 stop5h 27mAmerican Airlines

Deal found 8/13

$259

Thu 12/44:27 pmSTL - SYR

1 stop6h 24mDelta

Sun 12/711:25 amSYR - STL

1 stop6h 15mDelta

Deal found 8/14

$249

Wed 9/1710:28 amMCI - SYR

1 stop5h 41mAmerican Airlines

Sun 9/217:38 pmSYR - MCI

1 stop5h 27mAmerican Airlines

Deal found 8/14

$259

Sat 12/64:50 pmSTL - SYR

1 stop6h 05mDelta

Mon 12/811:25 amSYR - STL

1 stop6h 15mDelta

Deal found 8/12

$249

Wed 9/1710:28 amMCI - SYR

1 stop5h 41mAmerican Airlines

Sat 9/206:10 amSYR - MCI

2 stops9h 03mAmerican Airlines

Deal found 8/14

$264

Tue 9/23:10 pmSTL - SYR

1 stop6h 58mDelta

Sat 9/65:55 amSYR - STL

1 stop7h 36mDelta

Deal found 8/13

$254

Last-minute flights from Missouri to Syracuse
Discover last-minute flight deals from Missouri to Syracuse. Data last updated August 14, 2025 and is based on user searches.

Sat 8/165:25 pmSTL - SYR

1 stop4h 22mDelta

Wed 8/2012:10 pmSYR - STL

1 stop7h 57mDelta

Deal found 8/12

$324

Thu 8/212:02 pmSTL - SYR

1 stop18h 26mFrontier

Sat 8/231:48 pmSYR - STL

1 stop24h 19mFrontier

Deal found 8/13

$237

Fri 8/298:05 amJLN - SYR

2 stops9h 45mUnited Airlines

Tue 9/25:43 pmSYR - JLN

1 stop7h 00mUnited Airlines

Deal found 8/14

$290

Fri 8/299:17 amSTL - SYR

2 stops8h 33mUnited Airlines

Tue 9/26:57 pmSYR - STL

1 stop5h 47mUnited Airlines

Deal found 8/14

$355

Tue 9/23:10 pmSTL - SYR

1 stop6h 58mDelta

Sat 9/62:15 pmSYR - STL

1 stop5h 52mDelta

Deal found 8/14

$254

Tue 9/26:02 amSTL - SYR

2 stops7h 11mAmerican Airlines

Sat 9/612:01 pmSYR - STL

1 stop5h 14mAmerican Airlines

Deal found 8/14

$259

Tue 9/95:25 pmSTL - SYR

1 stop4h 22mDelta

Wed 9/175:55 amSYR - STL

1 stop7h 26mDelta

Deal found 8/14

$249

Tue 9/98:15 amSTL - SYR

1 stop4h 56mUnited Airlines

Wed 9/176:00 amSYR - STL

2 stops9h 19mUnited Airlines

Deal found 8/14

$350

Wed 9/174:06 pmMCI - SYR

1 stop6h 53mDelta

Sat 9/205:55 amSYR - MCI

1 stop5h 28mDelta

Deal found 8/14

$259

Wed 9/1710:28 amMCI - SYR

1 stop5h 41mAmerican Airlines

Sat 9/206:10 amSYR - MCI

2 stops9h 03mAmerican Airlines

Deal found 8/14

$264

Wed 9/177:00 amMCI - SYR

2 stops9h 09mAmerican Airlines

Sun 9/217:38 pmSYR - MCI

1 stop5h 27mAmerican Airlines

Deal found 8/14

$381

Sat 9/274:10 pmSTL - SYR

1 stop7h 23mDelta

Sun 9/285:55 amSYR - STL

1 stop5h 04mDelta

Deal found 8/14

$294

One-way flights from Missouri to Syracuse
Search for one-way flight options from Missouri to Syracuse. Find affordable one-way fares based on user searches. Data last updated August 14, 2025.

Thu 10/25:15 pmMCI - SYR

1 stop17h 07mFrontier

Deal found 8/14

$119

Fri 10/311:13 amMCI - SYR

1 stop30h 37mMultiple Airlines

Deal found 8/14

$133

Sat 8/305:45 pmMCI - SYR

1 stop4h 02mDelta

Deal found 8/13

$153

Sat 10/45:15 amMCI - SYR

2 stops36h 30mMultiple Airlines

Deal found 8/14

$155

Fri 8/229:50 amSTL - SYR

2 stops26h 15mMultiple Airlines

Deal found 8/12

$163

Thu 10/25:15 amMCI - SYR

2 stops33h 27mMultiple Airlines

Deal found 8/14

$177

Wed 10/17:12 amMCI - SYR

1 stop11h 49mAmerican Airlines

Deal found 8/14

$211

Tue 9/27:54 pmSTL - SYR

3 stops45h 44mMultiple Airlines

Deal found 8/14

$212

Thu 12/189:50 amSTL - SYR

2 stops10h 15mMultiple Airlines

Deal found 8/14

$231

Fri 9/126:00 amMCI - SYR

1 stop13h 01mAmerican Airlines

Deal found 8/14

$233

Tue 9/304:05 pmMCI - SYR

3 stops49h 40mMultiple Airlines

Deal found 8/14

$234

Wed 10/14:05 pmMCI - SYR

3 stops25h 40mMultiple Airlines

Deal found 8/14

$236

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Tue 9/9

9:16 am-5:19 pm

1 stop7h 03m

Syracuse Hancock Intl

Wed 9/17

12:15 pm-7:05 pm

1 stop7h 50m

$249

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Tue 9/9

6:00 pm-11:40 pm

1 stop4h 40m

Syracuse Hancock Intl

Wed 9/17

6:47 pm-11:07 pm

1 stop5h 20m

$249

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Wed 10/15

6:00 pm-11:04 pm

1 stop4h 04m

Syracuse Hancock Intl

Sat 10/18

2:17 pm-6:02 pm

1 stop4h 45m

$249

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Fri 10/24

5:15 pm-12:20 am

1 stop6h 05m

Syracuse Hancock Intl

Sun 10/26

6:00 am-9:37 am

1 stop4h 37m

$249

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Thu 12/4

4:27 pm-11:51 pm

1 stop6h 24m

Syracuse Hancock Intl

Sun 12/7

11:25 am-4:40 pm

1 stop6h 15m

$249

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Sat 12/6

4:50 pm-11:55 pm

1 stop6h 05m

Syracuse Hancock Intl

Mon 12/8

11:25 am-4:40 pm

1 stop6h 15m

$249

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Sat 12/6

5:58 am-1:59 pm

2 stops7h 01m

Syracuse Hancock Intl

Mon 12/8

7:40 am-2:35 pm

1 stop7h 55m

$254

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Tue 9/2

3:10 pm-11:08 pm

1 stop6h 58m

Syracuse Hancock Intl

Sat 9/6

5:55 am-12:31 pm

1 stop7h 36m

$254

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Thu 9/18

6:30 pm-12:29 am

1 stop4h 59m

Syracuse Hancock Intl

Sun 9/21

7:38 pm-12:05 am

1 stop5h 27m

$259

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Wed 9/17

10:28 am-5:09 pm

1 stop5h 41m

Syracuse Hancock Intl

Sun 9/21

7:38 pm-12:05 am

1 stop5h 27m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 43 results

...

Best time to book a flight from Missouri to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Syracuse

What is the cheapest month to book a flight from Missouri to Syracuse?

Currently, January is the cheapest month in which you can book a flight from Missouri to Syracuse (average of $272). Flying from Missouri to Syracuse in July is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SYR?

When flying from Missouri to Syracuse, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

What airport do you fly into for flights to Syracuse from Missouri?
Located just 4.8 mi from the city center, Syracuse Hancock Intl (SYR) is the airport most travelers will use when flying to Syracuse from Missouri.
What are the cheapest airlines to fly from Missouri to Syracuse one-way?
One-way options have recently been found by users for as low as $119 on Frontier. Other airlines that offer cheap prices include Delta from $153 and American Airlines from $262 one-way.
What are the most popular routes from Missouri to Syracuse?
While some choose either Kansas City - Syracuse Hancock Intl or Springfield-Branson - Syracuse Hancock Intl, Lambert-St Louis - Syracuse Hancock Intl is the most popular route from Missouri to Syracuse.
Can I find deals for flights from Missouri to Syracuse that include hotel bookings?
Yes. In addition to deals on Missouri to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Syracuse?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Syracuse.
Can I find deals for business class flights from Missouri to Syracuse?
Yes. Cheapflights offers flight deals from Missouri to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Syracuse?
Currently, January is the cheapest month in which you can book a flight from Missouri to Syracuse (average of $272). Flying from Missouri to Syracuse in July is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Liverpool

Cicero

East Syracuse

Waterloo

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Top 3 airlines flying from Missouri to Syracuse

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$198	Average$385	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$236	Average$346	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$248	Average$386	FlexibilityNo cancel fee	On-time69%

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$119+ Cheap flights from Missouri to Syracuse (SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Missouri to Syracuse

Keep the following information in mind while searching for Missouri to Syracuse flight deals. Data was last updated August 14, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Missouri to Syracuse

Cheapest flights from Missouri to SyracuseExplore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Explore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Syracuse that are best for you.

Best time to book a flight from Missouri to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Syracuse

What is the cheapest month to book a flight from Missouri to Syracuse?

What is the cheapest time of day to fly from MO to SYR?

Find hourly flight availability from Missouri to Syracuse. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Syracuse from Missouri?

What are the cheapest airlines to fly from Missouri to Syracuse one-way?

What are the most popular routes from Missouri to Syracuse?

Can I find deals for flights from Missouri to Syracuse that include hotel bookings?

How can I find direct flights from Missouri to Syracuse?

Can I find deals for business class flights from Missouri to Syracuse?

What is the cheapest month to book a flight from Missouri to Syracuse?

Traveling to a place near Syracuse?

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Alternative routes for Missouri to Syracuse

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Top 3 airlines flying from Missouri to Syracuse

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Cheapest flights from Missouri to Syracuse
Explore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.