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Syracuse

$126+ Cheap flights from Missouri to Syracuse (SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SYR
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Missouri to Syracuse

Cheapest flights from Missouri to Syracuse
Explore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Mytrip deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:54 amSTL - SYR
1 stop6h 56mFrontier
Fri 12/128:20 pmSYR - STL
1 stop27h 13mFrontier
Deal found 11/5$133
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/203:14 pmSTL - SYR
1 stop16h 49mFrontier
Mon 11/2410:24 amSYR - STL
1 stop29h 05mFrontier
Deal found 11/4$217
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/810:47 amSTL - SYR
2 stops24h 18mMultiple Airlines
Fri 12/128:20 pmSYR - STL
1 stop27h 13mMultiple Airlines
Deal found 11/5$229
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:40 amSTL - SYR
1 stop4h 28mDelta
Fri 12/512:58 pmSYR - STL
1 stop5h 12mDelta
Deal found 11/5$264
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:10 pmSTL - SYR
1 stop4h 59mUnited Airlines
Mon 12/295:30 amSYR - STL
1 stop7h 07mUnited Airlines
Deal found 11/6$286
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/201:35 pmSGF - SYR
1 stop8h 40mUnited Airlines
Mon 11/246:15 amSYR - SGF
1 stop5h 36mUnited Airlines
Deal found 11/5$309
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1910:23 amMCI - SYR
1 stop6h 33mDelta
Sun 11/236:00 amSYR - MCI
1 stop6h 13mDelta
Deal found 11/4$309
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2411:05 amSTL - SYR
1 stop4h 35mUnited Airlines
Fri 11/2810:26 amSYR - STL
2 stops8h 13mUnited Airlines
Deal found 11/6$313
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/199:58 amMCI - SYR
1 stop5h 42mUnited Airlines
Sun 11/236:00 amSYR - MCI
2 stops9h 21mUnited Airlines
Deal found 11/4$314
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:02 amSTL - SYR
1 stop7h 04mAmerican Airlines
Tue 11/255:30 amSYR - STL
1 stop4h 50mAmerican Airlines
Deal found 11/6$319
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/165:47 pmMCI - SYR
1 stop4h 23mDelta
Thu 12/116:00 amSYR - MCI
1 stop4h 56mDelta
Deal found 11/4$329
This Mytrip deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:00 amMCI - SYR
1 stop10h 31mMultiple Airlines
Mon 12/18:28 pmSYR - MCI
2 stops16h 35mMultiple Airlines
Deal found 11/5$333

Cheap flight deals from Missouri to Syracuse

Keep the following information in mind while searching for Missouri to Syracuse flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$133
(Mytrip)

One-way from

$126
(Kiwi.com)

Popular in

October

Cheapest in

January

Average price

$378
Provider with most accurate pricing for Lambert-St Louis-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Syracuse Hancock Intl flights.
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From Missouri to Syracuse Hancock Intl
Search Deals
One-way flight from Missouri to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($24 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Missouri to Syracuse that are best for you.

Fly from

Missouri

Fly to

Syracuse

Route

Depart

Return

Price

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Mon 12/8

9:54 am-5:50 pm

1 stop6h 56m

Syracuse Hancock Intl

Fri 12/12

8:20 pm-10:33 pm

1 stop27h 13m

$133

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Thu 11/20

3:14 pm-9:03 am

1 stop16h 49m

Syracuse Hancock Intl

Mon 11/24

10:24 am-2:29 pm

1 stop29h 05m

$217

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Mon 12/8

10:47 am-12:05 pm

2 stops24h 18m

Syracuse Hancock Intl

Fri 12/12

8:20 pm-10:33 pm

1 stop27h 13m

$229

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Sun 11/23

6:40 am-12:08 pm

1 stop4h 28m

Syracuse Hancock Intl

Fri 12/5

12:58 pm-5:10 pm

1 stop5h 12m

$264

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Tue 12/23

3:10 pm-9:09 pm

1 stop4h 59m

Syracuse Hancock Intl

Mon 12/29

5:30 am-11:37 am

1 stop7h 07m

$286

SpringfieldSyracuse

SGF - SYR

SGFSYR

Springfield-Branson

Fri 3/6

5:06 pm-11:53 pm

1 stop5h 47m

Syracuse Hancock Intl

Tue 3/10

6:00 am-11:14 am

1 stop6h 14m

$299

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Thu 11/20

6:00 am-2:49 pm

1 stop7h 49m

Syracuse Hancock Intl

Sun 11/23

6:00 am-1:11 pm

1 stop8h 11m

$309

SpringfieldSyracuse

SGF - SYR

SGFSYR

Springfield-Branson

Thu 11/20

1:35 pm-11:15 pm

1 stop8h 40m

Syracuse Hancock Intl

Mon 11/24

6:15 am-10:51 am

1 stop5h 36m

$309

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Wed 11/19

10:23 am-5:56 pm

1 stop6h 33m

Syracuse Hancock Intl

Sun 11/23

6:00 am-11:13 am

1 stop6h 13m

$309

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Mon 11/24

11:05 am-4:40 pm

1 stop4h 35m

Syracuse Hancock Intl

Fri 11/28

10:26 am-5:39 pm

2 stops8h 13m

$313

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 41 results
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Best time to book a flight from Missouri to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Syracuse

What is the cheapest month to book a flight from Missouri to Syracuse?

Currently, July is the cheapest month in which you can book a flight from Missouri to Syracuse (average of $155). Flying from Missouri to Syracuse in November is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SYR?

Find hourly flight availability from Missouri to Syracuse. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

When flying from Missouri to Syracuse, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 26% versus a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Syracuse from Missouri?

    Located just 4.8 mi from the city center, Syracuse Hancock Intl (SYR) is the airport most travelers will use when flying to Syracuse from Missouri.

  • How long is the flight from Missouri to Syracuse?

    There are many flights that can get you from Missouri to Syracuse in 4h 28m. Fly via Frontier, Delta, or United Airlines to get the fastest option. The distance between Missouri and Syracuse is about 801 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Syracuse one-way?

    One-way options have recently been found by users for as low as $126 on Frontier. Other airlines that offer cheap prices include Delta from $239 and United Airlines from $333 one-way.

  • What are the most popular routes from Missouri to Syracuse?

    While some choose either Kansas City - Syracuse Hancock Intl or Springfield-Branson - Syracuse Hancock Intl, Lambert-St Louis - Syracuse Hancock Intl is the most popular route from Missouri to Syracuse.

  • Can I find deals for flights from Missouri to Syracuse that include hotel bookings?

    Yes. In addition to deals on Missouri to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Syracuse.

  • Can I find deals for business class flights from Missouri to Syracuse?

    Yes. Cheapflights offers flight deals from Missouri to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Syracuse?

    Currently, July is the cheapest month in which you can book a flight from Missouri to Syracuse (average of $155). Flying from Missouri to Syracuse in November is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Liverpool
East Syracuse
Waterloo

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Alternative routes for Missouri to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Syracuse

Discover the top 3 airlines that operate flights from Missouri to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$409FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$321FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$334Average$398FlexibilityNo cancel feeOn-time69%

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