HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Syracuse

$121+ Cheap flights from Missouri to Syracuse (SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SYR
Nov 16 — Nov 231
Sun 11/16
Sun 11/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Syracuse with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Missouri to Syracuse

Cheapest flights from Missouri to Syracuse
Explore the most affordable flight options available from Missouri to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 17, 2025.

This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amSTL - SYR
1 stop4h 38mAmerican Airlines
Tue 12/237:47 pmSYR - STL
1 stop5h 05mAmerican Airlines
Deal found 10/15$249
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:25 amSTL - SYR
1 stop6h 38mAmerican Airlines
Mon 11/36:12 pmSYR - STL
1 stop5h 55mAmerican Airlines
Deal found 10/15$259
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:12 pmMCI - SYR
1 stop5h 35mDelta
Sun 11/166:00 amSYR - MCI
1 stop4h 52mDelta
Deal found 10/15$259
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:47 pmMCI - SYR
2 stops8h 55mUnited Airlines
Sun 11/166:15 amSYR - MCI
1 stop5h 25mUnited Airlines
Deal found 10/16$264
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:00 amMCI - SYR
1 stop4h 50mAmerican Airlines
Wed 12/35:31 pmSYR - MCI
1 stop6h 23mAmerican Airlines
Deal found 10/16$274
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:00 amSTL - SYR
1 stop4h 36mDelta
Tue 11/256:00 amSYR - STL
1 stop4h 46mDelta
Deal found 10/15$284
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/15:55 amMCI - SYR
1 stop6h 17mDelta
Mon 11/36:00 amSYR - MCI
1 stop7h 29mDelta
Deal found 10/15$289
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:00 amMCI - SYR
2 stops8h 39mAmerican Airlines
Mon 11/36:12 pmSYR - MCI
1 stop6h 32mAmerican Airlines
Deal found 10/15$294
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/233:59 pmSTL - SYR
1 stop7h 21mDelta
Sun 10/266:39 pmSYR - STL
1 stop6h 02mDelta
Deal found 10/15$309
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/235:00 amSTL - SYR
2 stops8h 14mUnited Airlines
Sun 10/266:15 amSYR - STL
1 stop7h 13mUnited Airlines
Deal found 10/15$314
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/244:39 pmMCI - SYR
1 stop6h 41mDelta
Thu 11/137:01 pmSYR - MCI
1 stop5h 49mDelta
Deal found 10/16$314
This Mytrip deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2010:53 amSTL - SYR
1 stop6h 45mMultiple Airlines
Tue 11/2510:18 amSYR - STL
2 stops9h 18mMultiple Airlines
Deal found 10/15$317

Cheap flight deals from Missouri to Syracuse

Keep the following information in mind while searching for Missouri to Syracuse flight deals. Data was last updated October 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Delta)

One-way from

$121
(Kiwi.com)

Popular in

October

Cheapest in

January

Average price

$411
Provider with most accurate pricing for Lambert-St Louis-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Syracuse Hancock Intl flights.
Search Deals
From Missouri to Syracuse Hancock Intl
Search Deals
One-way flight from Missouri to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($11 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
Use the filters below to find and compare flights from Missouri to Syracuse that are best for you.

Fly from

Missouri

Fly to

Syracuse

Route

Depart

Return

Price

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Fri 12/19

6:00 am-11:38 am

1 stop4h 38m

Syracuse Hancock Intl

Tue 12/23

7:47 pm-11:52 pm

1 stop5h 05m

$249

SpringfieldSyracuse

SGF - SYR

SGFSYR

Springfield-Branson

Wed 2/18

11:45 am-11:13 pm

2 stops10h 28m

Syracuse Hancock Intl

Sat 2/21

3:00 pm-9:41 pm

1 stop7h 41m

$256

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Thu 10/30

6:25 am-2:03 pm

1 stop6h 38m

Syracuse Hancock Intl

Mon 11/3

6:12 pm-11:07 pm

1 stop5h 55m

$259

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Fri 12/12

5:12 pm-11:46 pm

1 stop5h 34m

Syracuse Hancock Intl

Mon 12/15

7:01 pm-11:55 pm

1 stop5h 54m

$259

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Sat 11/1

6:00 am-12:04 pm

1 stop5h 04m

Syracuse Hancock Intl

Mon 11/3

6:12 pm-11:07 pm

1 stop5h 55m

$259

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Sat 2/28

6:00 am-12:04 pm

1 stop5h 04m

Syracuse Hancock Intl

Tue 3/3

6:00 am-11:35 am

1 stop6h 35m

$259

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Fri 11/14

5:12 pm-11:47 pm

1 stop5h 35m

Syracuse Hancock Intl

Sun 11/16

6:00 am-9:52 am

1 stop4h 52m

$259

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Fri 11/14

1:47 pm-11:42 pm

2 stops8h 55m

Syracuse Hancock Intl

Sun 11/16

6:15 am-10:40 am

1 stop5h 25m

$264

Kansas CitySyracuse

MCI - SYR

MCISYR

Kansas City

Fri 12/12

1:40 pm-11:15 pm

1 stop8h 35m

Syracuse Hancock Intl

Mon 12/15

6:00 am-2:21 pm

2 stops9h 21m

$264

St. LouisSyracuse

STL - SYR

STLSYR

Lambert-St Louis

Thu 11/20

6:00 am-11:36 am

1 stop4h 36m

Syracuse Hancock Intl

Tue 11/25

6:00 am-9:46 am

1 stop4h 46m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 40 results
1
2
3
4

Best time to book a flight from Missouri to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Syracuse

What is the cheapest month to book a flight from Missouri to Syracuse?

Currently, July is the cheapest month in which you can book a flight from Missouri to Syracuse (average of $155). Flying from Missouri to Syracuse in November is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SYR?

Find hourly flight availability from Missouri to Syracuse. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 17, 2025.

When flying from Missouri to Syracuse, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 26% versus a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Syracuse from Missouri?

    Located just 4.8 mi from the city center, Syracuse Hancock Intl (SYR) is the airport most travelers will use when flying to Syracuse from Missouri.

  • How long is the flight from Missouri to Syracuse?

    There are many flights that can get you from Missouri to Syracuse in 4h 38m. Fly via American Airlines, Delta, or United Airlines to get the fastest option. The distance between Missouri and Syracuse is about 801 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to Syracuse?

    While some choose either Kansas City - Syracuse Hancock Intl or Springfield-Branson - Syracuse Hancock Intl, Lambert-St Louis - Syracuse Hancock Intl is the most popular route from Missouri to Syracuse.

  • Can I find deals for flights from Missouri to Syracuse that include hotel bookings?

    Yes. In addition to deals on Missouri to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Syracuse.

  • Can I find deals for business class flights from Missouri to Syracuse?

    Yes. Cheapflights offers flight deals from Missouri to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Syracuse?

    Currently, July is the cheapest month in which you can book a flight from Missouri to Syracuse (average of $155). Flying from Missouri to Syracuse in November is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Cicero
Liverpool
East Syracuse
Waterloo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to John F Kennedy Intl flights
Dallas/Fort Worth to John F Kennedy Intl flights
Dallas/Fort Worth to LaGuardia flights
Los Angeles to Newark flights
San Francisco to John F Kennedy Intl flights
O'Hare Intl to John F Kennedy Intl flights
San Francisco to Newark flights
Dallas/Fort Worth to Newark flights
Los Angeles to LaGuardia flights
Orlando to John F Kennedy Intl flights
Atlanta to LaGuardia flights
O'Hare Intl to Newark flights
O'Hare Intl to LaGuardia flights
Atlanta to John F Kennedy Intl flights
Hobby to LaGuardia flights
Hobby to John F Kennedy Intl flights
Seattle to John F Kennedy Intl flights
Hobby to Newark flights
Miami to John F Kennedy Intl flights
Tampa to John F Kennedy Intl flights
Fort Lauderdale to LaGuardia flights
San Francisco to LaGuardia flights
Fort Lauderdale to John F Kennedy Intl flights
Atlanta to Newark flights
Fort Lauderdale to Newark flights
George Bush Intcntl to John F Kennedy Intl flights
George Bush Intcntl to Newark flights
Denver to John F Kennedy Intl flights
Austin to John F Kennedy Intl flights
Tampa to LaGuardia flights
Miami to Newark flights
Raleigh to John F Kennedy Intl flights
Orlando to LaGuardia flights
Tampa to Newark flights
Denver to LaGuardia flights
George Bush Intcntl to LaGuardia flights
Raleigh to LaGuardia flights
Minneapolis to John F Kennedy Intl flights
Denver to Newark flights
Seattle to Newark flights
Charlotte to John F Kennedy Intl flights
Sky Harbor Intl to John F Kennedy Intl flights
San Diego to John F Kennedy Intl flights
Miami to LaGuardia flights
Austin to Newark flights
Minneapolis to LaGuardia flights
Orlando to Newark flights
Minneapolis to Newark flights
Boston to LaGuardia flights
Indianapolis to John F Kennedy Intl flights

Top 3 airlines flying from Missouri to Syracuse

Discover the top 3 airlines that operate flights from Missouri to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$387FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$322FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$380FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.