What are the cheapest airlines flying from Santiago to St. Louis round-trip?

According to our current data, American Airlines ($1,007), Delta ($1,020), and LATAM Airlines ($1,073) offers the cheapest pricing from Santiago to St. Louis.

What are the cheapest airlines to fly from Santiago to St. Louis one-way?

The cheapest airline one-way is Copa Airlines, with whom users have recently found tickets for as low as $491. However, be on the lookout for offers from Air Canada and LATAM Airlines, as they are both options that can get you from Santiago to St. Louis for a low price.

What is the cheapest month to book a flight from Santiago to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Santiago to St. Louis (average of $311). Flying from Santiago to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest day to fly from Santiago to St. Louis?

Travelers seeking maximum savings on their Santiago to St. Louis flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Santiago to St. Louis?

Users have found that leaving on a Monday can be a cost-effective option. It’s possible to save up to 34% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Santiago to St. Louis?

Flights from Santiago to St. Louis lean towards being more expensive in March. Prices are generally better when you fly from Santiago to St. Louis in November, with the cheapest ticket starting at $784.

What is the cheapest time of day to fly from SCL to STL?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santiago to St. Louis as you normally would.

Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santiago to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.

Can I find deals for business class flights from Santiago to St. Louis?

Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$491+ Flights from Santiago to St. Louis

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Cheap flight deals from Santiago to St. Louis

Round-trip from	$1,007 (American Airlines)
One-way from	$491 (Copa Airlines)
Popular in	March
Cheapest in	November
Average price	$1,019

From Santiago Arturo Merino Benitez to Lambert-St Louis

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One-way flight from Santiago Arturo Merino Benitez to Lambert-St Louis

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Highest demand for flights based on searches. 2% potential increase in price ($28 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($25 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Tue 7/299:50 pmSCL - STL

1 stop27h 07mAmerican Airlines

Tue 8/125:22 amSTL - SCL

1 stop24h 33mAmerican Airlines

Deal found 6/11

$1,007

Tue 7/84:55 pmSCL - STL

2 stops20h 39mDelta

Mon 7/145:23 pmSTL - SCL

1 stop12h 37mDelta

Deal found 6/9

$1,020

Mon 7/2812:37 amSCL - STL

2 stops24h 16mLATAM Airlines

Tue 8/121:26 pmSTL - SCL

1 stop16h 34mLATAM Airlines

Deal found 6/11

$1,073

Tue 7/2912:12 pmSCL - STL

2 stops28h 04mMultiple Airlines

Tue 8/125:26 pmSTL - SCL

3 stops33h 51mMultiple Airlines

Deal found 6/11

$1,109

Tue 6/1712:13 amSCL - STL

2 stops19h 15mCopa Airlines

Sat 6/218:05 amSTL - SCL

2 stops19h 59mCopa Airlines

Deal found 6/11

$1,591

Best flights from Santiago to St. Louis
Discover carefully curated flight deals from Santiago to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Tue 7/299:50 pmSCL - STL

1 stop27h 07mAmerican Airlines

Tue 8/125:22 amSTL - SCL

1 stop24h 33mAmerican Airlines

Deal found 6/11

$1,007

Tue 7/84:55 pmSCL - STL

2 stops20h 39mDelta

Mon 7/145:23 pmSTL - SCL

1 stop12h 37mDelta

Deal found 6/9

$1,020

Mon 7/2812:37 amSCL - STL

2 stops24h 16mLATAM Airlines

Tue 8/121:26 pmSTL - SCL

1 stop16h 34mLATAM Airlines

Deal found 6/11

$1,073

Tue 7/2912:12 pmSCL - STL

2 stops28h 04mMultiple Airlines

Tue 8/125:26 pmSTL - SCL

3 stops33h 51mMultiple Airlines

Deal found 6/11

$1,109

Mon 7/72:23 amSCL - STL

2 stops32h 36mCopa Airlines

Mon 7/148:00 amSTL - SCL

2 stops20h 04mCopa Airlines

Deal found 6/9

$1,954

Last-minute flights from Santiago to St. Louis
Discover last-minute flight deals from Santiago to St. Louis. Data last updated June 12, 2025 and is based on user searches.

Tue 6/1712:13 amSCL - STL

2 stops19h 15mCopa Airlines

Sat 6/218:05 amSTL - SCL

2 stops19h 59mCopa Airlines

Deal found 6/11

$1,591

Wed 6/1811:05 pmSCL - STL

2 stops20h 00mDelta

Sat 6/2110:30 amSTL - SCL

2 stops19h 00mDelta

Deal found 6/10

$1,265

Wed 6/184:55 amSCL - STL

3 stops37h 09mMultiple Airlines

Sat 6/212:30 pmSTL - SCL

3 stops31h 00mMultiple Airlines

Deal found 6/11

$1,300

Wed 6/189:55 pmSCL - STL

1 stop27h 04mAmerican Airlines

Sat 6/215:21 pmSTL - SCL

1 stop12h 39mAmerican Airlines

Deal found 6/12

$1,339

Wed 6/187:20 amSCL - STL

2 stops17h 16mLATAM Airlines

Sat 6/215:30 pmSTL - SCL

1 stop12h 30mLATAM Airlines

Deal found 6/11

$1,369

Tue 7/84:55 pmSCL - STL

2 stops20h 39mDelta

Mon 7/145:23 pmSTL - SCL

1 stop12h 37mDelta

Deal found 6/9

$1,020

Mon 7/2812:37 amSCL - STL

2 stops24h 16mLATAM Airlines

Tue 8/1211:02 amSTL - SCL

2 stops17h 38mLATAM Airlines

Deal found 6/11

$1,073

Tue 7/299:50 pmSCL - STL

1 stop27h 07mAmerican Airlines

Tue 8/125:22 amSTL - SCL

1 stop24h 33mAmerican Airlines

Deal found 6/11

$1,007

Tue 7/2912:12 pmSCL - STL

2 stops28h 04mMultiple Airlines

Tue 8/125:26 pmSTL - SCL

3 stops33h 51mMultiple Airlines

Deal found 6/11

$1,109

One-way flights from Santiago to St. Louis
Search for one-way flight options from Santiago to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Fri 11/212:42 amSCL - STL

2 stops34h 06mCopa Airlines

Deal found 6/10

$491

Sat 11/228:50 pmSCL - STL

1 stop21h 36mAir Canada

Deal found 6/10

$593

Thu 6/195:28 pmSCL - STL

3 stops55h 25mMultiple Airlines

Deal found 6/11

$645

Thu 6/198:40 pmSCL - STL

1 stop14h 03mLATAM Airlines

Deal found 6/11

$671

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 7/29

9:50 pm-11:57 pm

1 stop27h 07m

Lambert-St Louis

Tue 8/12

5:22 am-6:55 am

1 stop24h 33m

$1,007

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 7/8

4:55 pm-12:34 pm

2 stops20h 39m

Lambert-St Louis

Mon 7/14

5:23 pm-7:00 am

1 stop12h 37m

$1,020

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 7/28

12:37 am-11:53 pm

2 stops24h 16m

Lambert-St Louis

Tue 8/12

11:02 am-5:40 am

2 stops17h 38m

$1,073

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 7/29

12:12 pm-3:16 pm

2 stops28h 04m

Lambert-St Louis

Tue 8/12

5:26 pm-4:17 am

3 stops33h 51m

$1,109

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 7/7

2:23 am-9:59 am

2 stops32h 36m

Lambert-St Louis

Mon 7/14

8:00 am-5:04 am

2 stops20h 04m

$1,954

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Fri 11/21

2:42 am-9:48 am

2 stops34h 06m

$491

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sat 11/22

8:50 pm-3:26 pm

1 stop21h 36m

$593

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 6/19

5:28 pm-11:53 pm

3 stops55h 25m

$645

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 6/19

8:40 pm-9:43 am

1 stop14h 03m

$671

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to St. Louis

Rainfall in St. Louis by month

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get a feel of what it's like to fly with Delta, LATAM Airlines and Copa Airlines from Santiago to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,950 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,785 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Copa Airlines

7.5

Good

1,451 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Air Canada

7.1

Good

9,531 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Santiago to St. Louis round-trip?
According to our current data, American Airlines ($1,007), Delta ($1,020), and LATAM Airlines ($1,073) offers the cheapest pricing from Santiago to St. Louis.
What are the cheapest airlines to fly from Santiago to St. Louis one-way?
The cheapest airline one-way is Copa Airlines, with whom users have recently found tickets for as low as $491. However, be on the lookout for offers from Air Canada and LATAM Airlines, as they are both options that can get you from Santiago to St. Louis for a low price.
Can I find deals for flights from Santiago to St. Louis that include hotel bookings?
Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santiago to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.
Can I find deals for business class flights from Santiago to St. Louis?
Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santiago to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Santiago to St. Louis (average of $311). Flying from Santiago to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Maryland Heights

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Top airline flying from Santiago to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$843	Average$1,159	FlexibilityNo cancel fee	On-timeN/A

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$491+ Cheap flights from Santiago (SCL) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santiago to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Santiago to St. Louis

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. LouisExplore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santiago to St. Louis

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

Reviews of airlines servicing St. Louis

Get a feel of what it's like to fly with Delta, LATAM Airlines and Copa Airlines from Santiago to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santiago to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Santiago to St. Louis round-trip?

What are the cheapest airlines to fly from Santiago to St. Louis one-way?

Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

How can I find direct flights from Santiago to St. Louis?

Can I find deals for business class flights from Santiago to St. Louis?

What is the cheapest month to book a flight from Santiago to St. Louis?

Traveling to a place near Santiago?

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Complete your trip

Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.

Top airline flying from Santiago to St. Louis

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Travel Smart

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.