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$387+ Cheap flights from Santiago (SCL) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/11. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — STL
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Santiago to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$980
(Delta)

One-way from

$387
(eDestinos)

Popular in

March

Cheapest in

November

Average price

$1,058
From Santiago Arturo Merino Benitez to Lambert-St Louis
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One-way flight from Santiago Arturo Merino Benitez to Lambert-St Louis
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Highest demand for flights based on searches. 3% potential increase in price ($41 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1611:30 pmSCL - STL
2 stops17h 05mDelta
Wed 9/249:19 amSTL - SCL
2 stops18h 41mDelta
Deal found 7/27$980
This LATAM Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:15 pmSCL - STL
1 stop14h 25mLATAM Airlines
Mon 11/174:00 pmSTL - SCL
1 stop12h 00mLATAM Airlines
Deal found 7/26$989
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/119:55 pmSCL - STL
1 stop28h 04mAmerican Airlines
Thu 9/185:28 amSTL - SCL
1 stop24h 27mAmerican Airlines
Deal found 7/28$999
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/115:55 amSCL - STL
3 stops35h 23mMultiple Airlines
Thu 9/1810:35 amSTL - SCL
3 stops31h 30mMultiple Airlines
Deal found 7/28$1,039

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Santiago

Fly to

St. Louis

Route

Depart

Return

Price

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 9/16

9:40 pm-9:59 am

1 stop14h 19m

Lambert-St Louis

Wed 9/24

1:26 pm-7:45 am

2 stops16h 19m

$980

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 11/13

11:15 pm-10:40 am

1 stop14h 25m

Lambert-St Louis

Mon 11/17

4:00 pm-7:00 am

1 stop12h 00m

$989

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 9/11

9:55 pm-11:59 pm

1 stop28h 04m

Lambert-St Louis

Thu 9/18

5:28 am-7:55 am

1 stop24h 27m

$999

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 9/11

5:55 am-3:18 pm

3 stops35h 23m

Lambert-St Louis

Thu 9/18

10:35 am-8:05 pm

3 stops31h 30m

$1,039

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 8/11

11:25 pm-11:47 pm

2 stops25h 22m

$387

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 12/1

11:25 pm-3:58 pm

2 stops19h 33m

$577

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sun 11/30

12:25 am-8:09 am

2 stops34h 44m

$581

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sat 8/9

9:55 pm-11:59 pm

1 stop27h 04m

$704

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sat 11/15

10:45 pm-3:50 pm

1 stop20h 05m

$1,856

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to St. Louis

How much does it cost to fly round-trip from Santiago to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated July 29, 2025.
Read through reviews of airlines operating flights from Santiago to St. Louis, such as Delta, LATAM Airlines, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,979 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
Delta
8.0
Very good
7,979 reviews
Delta
8.0
Very good
7,979 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
LATAM Airlines
7.5
Good
1,822 reviews
Delta
8.0
Very good
7,979 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,979 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,979 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.

Related info for your journey

Find useful and relevant information for your journey from Santiago to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Santiago to St. Louis round-trip?

    According to our current data, Delta ($980), LATAM Airlines ($989), and American Airlines ($999) offers the cheapest pricing from Santiago to St. Louis. You may be able to fly from Santiago to St. Louis for 3% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Santiago to St. Louis one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $577. However, be on the lookout for offers from LATAM Airlines and American Airlines, as they are both options that can get you from Santiago to St. Louis for a low price.

  • Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

    Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.

  • Can I find deals for business class flights from Santiago to St. Louis?

    Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Santiago to St. Louis (average of $311). Flying from Santiago to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
O'Fallon
Maryland Heights
Fairview Heights
Collinsville
Eureka
St. Peters
Glencoe
Alton
Chesterfield
Festus
Farmington

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Top 2 airlines flying from Santiago to St. Louis

Discover the top 2 airlines that operate flights from Santiago to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$782Average$1,076FlexibilityNo cancel feeOn-time71%
DeltaCheapest$925Average$1,159FlexibilityNo cancel feeOn-timeN/A

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