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St. Louis

$333+ Cheap flights from Santiago (SCL) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/3. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — STL
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This LATAM Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1412:40 am
SCL
-
STL
2 stops18h 22m
LATAM Airlines
Wed 8/51:30 pm
STL
-
SCL
2 stops16h 25m
LATAM Airlines
Deal found 1/26$800
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:05 pm
SCL
-
STL
2 stops19h 57m
Delta
Wed 8/51:30 pm
STL
-
SCL
1 stop16h 45m
Delta
Deal found 1/26$816
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:30 pm
SCL
-
STL
1 stop27h 15m
American Airlines
Wed 8/55:18 am
STL
-
SCL
1 stop24h 32m
American Airlines
Deal found 1/27$828
This LATAM Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/111:05 pm
SCL
-
STL
2 stops34h 02m
LATAM Airlines
Wed 7/86:00 am
STL
-
SCL
2 stops23h 00m
LATAM Airlines
Deal found 1/28$848
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:10 pm
SCL
-
STL
1 stop12h 56m
Delta
Mon 3/910:12 am
STL
-
SCL
1 stop19h 28m
Delta
Deal found 1/27$849
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2410:45 pm
SCL
-
STL
1 stop13h 38m
United Airlines
Tue 3/108:17 am
STL
-
SCL
2 stops21h 33m
United Airlines
Deal found 1/27$855
This LATAM Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:15 am
SCL
-
STL
3 stops19h 21m
LATAM Airlines
Mon 3/96:59 pm
STL
-
SCL
2 stops17h 06m
LATAM Airlines
Deal found 1/27$868

Find flight deals from Santiago to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$800
(LATAM Airlines)

One-way from

$333
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$1,150
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Lambert-St Louis flights.
Search Deals
From Santiago Arturo Merino Benitez to Lambert-St Louis
Search Deals
One-way flight from Santiago Arturo Merino Benitez to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Santiago

Fly to

St. Louis

Route

Depart

Return

Price

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

11:05 pm-6:02 pm

2 stops19h 57m

Lambert-St Louis

Wed 8/5

1:30 pm-7:15 am

1 stop16h 45m

$816

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 7/14

12:40 am-6:02 pm

2 stops18h 22m

Lambert-St Louis

Wed 8/5

1:30 pm-6:55 am

2 stops16h 25m

$817

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:30 pm-10:45 pm

1 stop27h 15m

Lambert-St Louis

Wed 8/5

5:18 am-6:50 am

1 stop24h 32m

$829

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/1

11:05 pm-8:07 am

2 stops34h 02m

Lambert-St Louis

Wed 7/8

6:00 am-6:00 am

2 stops23h 00m

$851

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 2/25

10:45 pm-9:23 am

1 stop13h 38m

Lambert-St Louis

Thu 3/12

7:41 am-7:50 am

2 stops22h 09m

$855

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 2/26

10:35 am-11:36 pm

2 stops16h 01m

Lambert-St Louis

Tue 3/10

10:12 am-7:00 am

2 stops18h 48m

$855

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 2/25

10:45 pm-3:38 pm

1 stop19h 53m

Lambert-St Louis

Mon 3/9

6:00 am-7:50 am

1 stop23h 50m

$855

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 2/26

8:50 am-11:36 pm

2 stops17h 46m

Lambert-St Louis

Mon 3/9

6:59 pm-2:05 pm

2 stops17h 06m

$855

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 2/24

10:45 pm-9:23 am

1 stop13h 38m

Lambert-St Louis

Tue 3/10

10:05 am-7:50 am

1 stop19h 45m

$855

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 2/26

10:45 pm-9:23 am

1 stop13h 38m

Lambert-St Louis

Thu 3/12

10:05 am-7:50 am

1 stop19h 45m

$855

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 12 results
1
2
  • Most accurate provider: When it comes to deals on Santiago-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to St. Louis

What is the cheapest month to book a flight from Santiago to St. Louis?

Currently, July is the cheapest month in which you can book a flight from Santiago to St. Louis (average of $685). Flying from Santiago to St. Louis in January is currently the most expensive (average of $1,031). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santiago to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated January 29, 2026.
Read through reviews of airlines operating flights from Santiago to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Entertainment

7.8

Food

7.2

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Entertainment

7.8

Food

7.2

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Entertainment

7.8

Food

7.2

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Santiago to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to St. Louis?

    A quick flight from Santiago to St. Louis can take about 18h 22m. Delta provides one of the quickest options available for as low as $817. The distance between Santiago and St. Louis is about 5137 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Santiago to St. Louis round-trip?

    According to our current data, Delta ($877), and American Airlines ($948) offers the cheapest pricing from Santiago to St. Louis. You may be able to fly from Santiago to St. Louis for 10% less than the average price by searching for these airlines.

  • Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

    Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.

  • Can I find deals for business class flights from Santiago to St. Louis?

    Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to St. Louis?

    Currently, July is the cheapest month in which you can book a flight from Santiago to St. Louis (average of $685). Flying from Santiago to St. Louis in January is currently the most expensive (average of $1,031). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Santiago to St. Louis

Discover the top 2 airlines that operate flights from Santiago to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$877Average$1,159FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$948Average$1,150FlexibilityNo cancel feeOn-time71%

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