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$471+ Cheap flights from Santiago (SCL) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — STL
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Santiago to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$764
(Delta)

One-way from

$471
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$877
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Lambert-St Louis flights.
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From Santiago Arturo Merino Benitez to Lambert-St Louis
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One-way flight from Santiago Arturo Merino Benitez to Lambert-St Louis
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Highest demand for flights based on searches. 6% potential increase in price ($67 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:45 pmSCL - STL
1 stop20h 05mUnited Airlines
Tue 11/114:35 pmSTL - SCL
1 stop13h 15mUnited Airlines
Deal found 10/26$761
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:30 pmSCL - STL
1 stop20h 03mDelta
Mon 11/175:17 pmSTL - SCL
2 stops17h 48mDelta
Deal found 10/26$764
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/811:30 pmSCL - STL
2 stops20h 39mDelta
Wed 11/129:33 amSTL - SCL
1 stop19h 07mDelta
Deal found 10/26$795
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:45 pmSCL - STL
1 stop14h 54mUnited Airlines
Mon 11/104:35 pmSTL - SCL
1 stop13h 15mUnited Airlines
Deal found 10/26$802
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:45 pmSCL - STL
2 stops16h 43mUnited Airlines
Fri 11/144:35 pmSTL - SCL
1 stop13h 15mUnited Airlines
Deal found 10/26$842
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/910:45 pmSCL - STL
1 stop20h 19mUnited Airlines
Tue 12/166:15 amSTL - SCL
1 stop23h 35mUnited Airlines
Deal found 10/26$875
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/911:25 pmSCL - STL
2 stops20h 45mDelta
Tue 12/167:05 amSTL - SCL
2 stops20h 30mDelta
Deal found 10/26$885
This LATAM Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/84:35 amSCL - STL
2 stops20h 22mLATAM Airlines
Tue 12/169:30 amSTL - SCL
2 stops18h 05mLATAM Airlines
Deal found 10/26$901
This Air Canada deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:55 pmSCL - STL
1 stop21h 34mAir Canada
Fri 11/144:05 pmSTL - SCL
1 stop17h 10mAir Canada
Deal found 10/26$980
This LATAM Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:30 pmSCL - STL
2 stops19h 15mLATAM Airlines
Thu 12/186:00 amSTL - SCL
2 stops21h 35mLATAM Airlines
Deal found 10/27$1,003
This Air Canada deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:55 pmSCL - STL
2 stops27h 59mAir Canada
Wed 11/124:05 pmSTL - SCL
1 stop17h 10mAir Canada
Deal found 10/26$1,034

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Santiago

Fly to

St. Louis

Route

Depart

Return

Price

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 11/13

11:10 pm-10:43 am

1 stop14h 33m

Lambert-St Louis

Mon 11/17

1:55 pm-7:40 am

1 stop14h 45m

$764

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 11/13

6:30 pm-10:43 am

2 stops19h 13m

Lambert-St Louis

Mon 11/17

5:17 pm-2:05 pm

2 stops17h 48m

$764

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sat 11/8

11:25 pm-1:00 pm

2 stops16h 35m

Lambert-St Louis

Wed 11/12

9:33 am-5:50 am

2 stops17h 17m

$795

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Fri 11/7

10:45 pm-10:39 am

1 stop14h 54m

Lambert-St Louis

Thu 11/13

4:35 pm-8:50 am

1 stop13h 15m

$802

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sat 11/8

10:45 pm-3:46 pm

2 stops20h 01m

Lambert-St Louis

Tue 11/11

4:35 pm-8:50 am

1 stop13h 15m

$802

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sat 11/8

10:45 pm-10:39 am

1 stop14h 54m

Lambert-St Louis

Thu 11/13

4:35 pm-8:50 am

1 stop13h 15m

$802

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 1/7

7:25 am-10:33 pm

3 stops42h 08m

$471

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 1/6

12:20 am-8:53 am

2 stops35h 33m

$718

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 1/7

10:45 pm-9:22 am

1 stop13h 37m

$910

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 11/13

8:50 am-11:44 pm

2 stops17h 54m

$2,409

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Showing 1-10 of 11 results
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Compare providers for flights from Santiago to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to St. Louis in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santiago-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santiago-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santiago-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 28, 2025.
Read through reviews of airlines operating flights from Santiago to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!

Related info for your journey

Find useful and relevant information for your journey from Santiago to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to St. Louis?

    A quick flight from Santiago to St. Louis can take about 14h 33m. LATAM Airlines provides one of the quickest options available for as low as $764. The distance between Santiago and St. Louis is about 5137 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Santiago to St. Louis round-trip?

    According to our current data, American Airlines ($782), and Delta ($843) offers the cheapest pricing from Santiago to St. Louis. You may be able to fly from Santiago to St. Louis for 20% less than the average price by searching for these airlines.

  • Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

    Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.

  • Can I find deals for business class flights from Santiago to St. Louis?

    Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Top 2 airlines flying from Santiago to St. Louis

Discover the top 2 airlines that operate flights from Santiago to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$782Average$1,091FlexibilityNo cancel feeOn-time71%
DeltaCheapest$843Average$1,065FlexibilityNo cancel feeOn-timeN/A

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