$282+ Cheap flights from Santa Fe to St. Louis (SAF - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — STL
Nov 13 — Nov 201
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Santa Fe to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Fe to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Santa Fe to St. LouisExplore the most affordable flight options available from Santa Fe to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
Explore the most affordable flight options available from Santa Fe to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/221:16 pm -
1 stop8h 16m
Wed 12/306:00 am -
1 stop7h 18m
Deal found 10/10![American Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:05 am -
1 stop7h 25m
Sun 11/85:00 am -
1 stop5h 39m
Deal found 10/13![American Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/221:16 pm -
1 stop8h 16m
Tue 12/298:22 pm -
1 stop16h 56m
Deal found 10/10![American Airlines logo]()
$453
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:30 am -
2 stops10h 10m
Sun 11/84:39 pm -
1 stop4h 50m
Deal found 10/13![United Airlines logo]()
$498
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:48 pm -
1 stop6h 10m
Mon 12/286:00 am -
1 stop7h 18m
Deal found 10/11![American Airlines logo]()
$542
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:30 am -
1 stop5h 27m
Tue 11/171:40 pm -
1 stop7h 49m
Deal found 10/11![United Airlines logo]()
$551
Best flights from Santa Fe to St. LouisDiscover carefully curated flight deals from Santa Fe to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
Discover carefully curated flight deals from Santa Fe to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:30 am -
2 stops10h 10m
Sun 11/84:39 pm -
1 stop4h 50m
Deal found 10/13![United Airlines logo]()
$498
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:48 pm -
1 stop6h 10m
Mon 12/286:00 am -
1 stop7h 18m
Deal found 10/12![American Airlines logo]()
$542
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:30 am -
1 stop5h 27m
Tue 11/171:40 pm -
1 stop7h 49m
Deal found 10/11![United Airlines logo]()
$551
Last-minute flights from Santa Fe to St. LouisDiscover last-minute flight deals from Santa Fe to St. Louis. Data last updated October 14, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Fe to St. Louis. Data last updated October 14, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:26 pm -
1 stop5h 16m
Thu 10/293:20 pm -
1 stop5h 06m
Deal found 10/10![American Airlines logo]()
$735
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:05 am -
1 stop7h 25m
Sun 11/85:00 am -
1 stop5h 39m
Deal found 10/13![American Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:30 am -
2 stops10h 10m
Sun 11/84:39 pm -
1 stop4h 50m
Deal found 10/13![United Airlines logo]()
$498
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:30 am -
1 stop5h 27m
Tue 11/171:40 pm -
1 stop7h 49m
Deal found 10/11![United Airlines logo]()
$551
One-way flights from Santa Fe to St. LouisSearch for one-way flight options from Santa Fe to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 14, 2026.
Search for one-way flight options from Santa Fe to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 14, 2026.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:54 pm -
1 stop8h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/13![American Airlines logo]()
$282
Find flight deals from Santa Fe to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $337 (American Airlines) |
One-way from | $282 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Fe to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
Use the filters below to find and compare flights from Santa Fe to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Sat 11/7
12:54 pm-10:24 pm
1 stop8h 30m
Lambert-St Louis
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$282
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Sat 10/31
10:30 am-9:40 pm
2 stops10h 10m
Lambert-St Louis
Sun 11/8
4:39 pm-8:29 pm
1 stop4h 50m
$498
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Fri 12/11
12:48 pm-7:58 pm
1 stop6h 10m
Lambert-St Louis
Mon 12/28
6:00 am-12:18 pm
1 stop7h 18m
$542
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Sat 11/14
10:30 am-4:57 pm
1 stop5h 27m
Lambert-St Louis
Tue 11/17
1:40 pm-8:29 pm
1 stop7h 49m
$551
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Santa Fe-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Fe-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Fe to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santa Fe with our price prediction graph.
SAF-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 14, 2026.
See what other customers who have flown with American Airlines from Santa Fe to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.4
Overall
7.0
Comfort
7.2
Crew
7.9
Food
6.4
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Boarding
7.4
Overall
7.0
Comfort
7.2
Crew
7.9
Food
6.4
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Santa Fe to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Maryland Heights
Chesterfield
Collinsville
Edwardsville
Glencoe
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Santa Fe
Popular flights
St. Louis flight routes
Alternative routes for Santa Fe to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Santa Fe to St. Louis by cabin class
Find flights from Santa Fe to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Santa Fe and St. Louis flights
Browse other Santa Fe and St. Louis flight options. Last updated on October 14, 2026.
Other flights from Santa Fe
Browse through other flights departing from Santa Fe. Flights are based on user searches made on Cheapflights and were last updated on October 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 14, 2026.
Top airline flying from Santa Fe to St. Louis
Discover the top airline that operate flights from Santa Fe to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$314 | Average$364 | FlexibilityNo cancel fee | On-time71% |