$272+ Cheap flights from Santa Fe to St. Louis (SAF - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — STL
Oct 2 — Oct 91
Round-trip
1 adult, Economy
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Find cheap flights from Santa Fe to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Fe to St. Louis
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One-way
Cheapest flights from Santa Fe to St. LouisExplore the most affordable flight options available from Santa Fe to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
Explore the most affordable flight options available from Santa Fe to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:05 am -
1 stop7h 39m
Mon 10/55:40 am -
1 stop5h 02m
Deal found 8/31![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:47 am -
1 stop5h 29m
Sat 9/195:43 am -
1 stop5h 00m
Deal found 8/31![American Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am -
2 stops7h 38m
Sat 9/194:40 pm -
1 stop4h 48m
Deal found 8/31![United Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 pm -
1 stop4h 44m
Fri 10/301:08 pm -
2 stops8h 21m
Deal found 8/29![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:31 pm -
1 stop4h 34m
Mon 11/232:48 pm -
1 stop5h 58m
Deal found 8/27![American Airlines logo]()
$393
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:08 pm -
1 stop4h 35m
Sun 9/64:50 pm -
1 stop5h 39m
Deal found 8/29![American Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:50 pm -
1 stop4h 50m
Sun 9/205:10 am -
1 stop5h 36m
Deal found 9/1![United Airlines logo]()
$427
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:22 pm -
2 stops7h 38m
Sun 9/69:00 am -
1 stop4h 47m
Deal found 8/29![United Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:09 pm -
1 stop8h 06m
Fri 11/138:15 pm -
1 stop17h 09m
Deal found 9/1![American Airlines logo]()
$450
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:55 pm -
1 stop22h 02m
Sat 10/311:40 pm -
1 stop4h 30m
Deal found 8/27![United Airlines logo]()
$492
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 pm -
1 stop4h 44m
Mon 10/58:00 am -
2 stops26h 21m
Deal found 9/1![United Airlines logo]()
$496
Best flights from Santa Fe to St. LouisDiscover carefully curated flight deals from Santa Fe to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
Discover carefully curated flight deals from Santa Fe to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:38 pm -
1 stop6h 05m
Sun 9/205:43 am -
1 stop5h 00m
Deal found 8/31![American Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:50 pm -
1 stop4h 50m
Sun 9/205:10 am -
1 stop5h 36m
Deal found 9/1![United Airlines logo]()
$427
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:47 am -
1 stop5h 29m
Sat 9/195:43 am -
1 stop5h 00m
Deal found 8/31![American Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:55 pm -
1 stop22h 02m
Sat 10/311:40 pm -
1 stop4h 30m
Deal found 8/27![United Airlines logo]()
$492
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:09 pm -
1 stop5h 13m
Fri 11/138:15 pm -
1 stop17h 09m
Deal found 8/30![American Airlines logo]()
$501
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:30 am -
2 stops10h 05m
Mon 11/98:50 am -
1 stop25h 22m
Deal found 8/27![United Airlines logo]()
$547
Last-minute flights from Santa Fe to St. LouisDiscover last-minute flight deals from Santa Fe to St. Louis. Data last updated September 2, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Fe to St. Louis. Data last updated September 2, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:08 pm -
1 stop4h 35m
Sun 9/64:50 pm -
1 stop5h 39m
Deal found 8/29![American Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:22 pm -
2 stops7h 38m
Sun 9/69:00 am -
1 stop4h 47m
Deal found 8/29![United Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:47 am -
1 stop5h 29m
Sat 9/195:43 am -
1 stop5h 00m
Deal found 8/31![American Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am -
2 stops7h 38m
Sat 9/194:40 pm -
1 stop4h 48m
Deal found 8/31![United Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:50 pm -
1 stop4h 50m
Sun 9/205:10 am -
1 stop5h 36m
Deal found 9/1![United Airlines logo]()
$427
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:05 am -
1 stop7h 39m
Mon 10/55:40 am -
1 stop5h 02m
Deal found 8/31![American Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 pm -
1 stop4h 44m
Mon 10/58:00 am -
2 stops26h 21m
Deal found 9/1![United Airlines logo]()
$496
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 pm -
1 stop4h 44m
Fri 10/301:08 pm -
2 stops8h 21m
Deal found 8/29![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:55 pm -
1 stop22h 02m
Sat 10/311:40 pm -
1 stop4h 30m
Deal found 8/27![United Airlines logo]()
$492
One-way flights from Santa Fe to St. LouisSearch for one-way flight options from Santa Fe to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 2, 2026.
Search for one-way flight options from Santa Fe to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 2, 2026.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:11 pm -
1 stop5h 48m
Deal found 9/1![American Airlines logo]()
$272
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/211:17 pm -
2 stops8h 42m
Deal found 9/1![United Airlines logo]()
$354
Find flight deals from Santa Fe to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $314 (American Airlines) |
One-way from | $272 (American Airlines) |
Popular in | October |
Cheapest in | November |
Average price | $394 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Fe to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
Use the filters below to find and compare flights from Santa Fe to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Fri 9/18
4:38 pm-11:43 pm
1 stop6h 05m
Lambert-St Louis
Sun 9/20
5:43 am-9:43 am
1 stop5h 00m
$344
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Tue 9/15
6:47 am-1:16 pm
1 stop5h 29m
Lambert-St Louis
Sat 9/19
5:43 am-9:43 am
1 stop5h 00m
$344
Quickest round-trip
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Wed 9/16
5:50 pm-11:40 pm
1 stop4h 50m
Lambert-St Louis
Sun 9/20
5:10 am-9:46 am
1 stop5h 36m
$427
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Wed 10/28
5:55 pm-4:57 pm
1 stop22h 02m
Lambert-St Louis
Sat 10/31
1:40 pm-5:10 pm
1 stop4h 30m
$492
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Thu 11/12
1:09 pm-7:22 pm
1 stop5h 13m
Lambert-St Louis
Fri 11/13
8:15 pm-12:24 pm
1 stop17h 09m
$501
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Fri 11/6
10:30 am-9:35 pm
2 stops10h 05m
Lambert-St Louis
Mon 11/9
8:50 am-9:12 am
1 stop25h 22m
$547
Cheapest one-way
Quickest one-way
Santa FeSt. Louis
SAF Santa Fe - STL Lambert-St Louis
SAFSTL
Santa Fe
Wed 10/21
1:17 pm-10:59 pm
2 stops8h 42m
$354
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Santa Fe-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Fe-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Fe to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santa Fe with our price prediction graph.
SAF-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 2, 2026.
See what other customers who have flown with American Airlines from Santa Fe to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.1
Food
6.4
Boarding
7.5
Comfort
7.2
Entertainment
6.8
Crew
7.9
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Overall
7.1
Food
6.4
Boarding
7.5
Comfort
7.2
Entertainment
6.8
Crew
7.9
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Santa Fe to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
Fairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
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Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
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Santa Fe and St. Louis flights
Browse other Santa Fe and St. Louis flight options. Last updated on September 2, 2026.
Other flights from Santa Fe
Browse through other flights departing from Santa Fe. Flights are based on user searches made on Cheapflights and were last updated on September 2, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 2, 2026.
Top airline flying from Santa Fe to St. Louis
Discover the top airline that operate flights from Santa Fe to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$324 | Average$394 | FlexibilityNo cancel fee | On-time71% |