$345+ Cheap flights from Santa Fe to St. Louis (SAF - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/2. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — STL
Jul 23 — Jul 301
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Santa Fe to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Fe to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Santa Fe to St. LouisExplore the most affordable flight options available from Santa Fe to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2026.
Explore the most affordable flight options available from Santa Fe to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2026.
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:23 pm
SAF
- STL
1 stop5h 41m
American Airlines
Thu 7/232:46 pm
STL
- SAF
1 stop5h 10m
American Airlines
Deal found 6/20![American Airlines logo]()
$393
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/265:13 pm
SAF
- STL
1 stop5h 46m
American Airlines
Mon 6/297:04 am
STL
- SAF
1 stop6h 21m
American Airlines
Deal found 6/21![American Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:22 pm
SAF
- STL
1 stop6h 21m
United Airlines
Sat 7/115:10 am
STL
- SAF
1 stop5h 34m
United Airlines
Deal found 6/22![United Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:13 pm
SAF
- STL
1 stop5h 46m
American Airlines
Sat 7/112:46 pm
STL
- SAF
1 stop5h 10m
American Airlines
Deal found 6/18![American Airlines logo]()
$435
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:00 pm
SAF
- STL
1 stop4h 47m
United Airlines
Fri 7/245:10 am
STL
- SAF
1 stop5h 34m
United Airlines
Deal found 6/18![United Airlines logo]()
$489
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/261:22 pm
SAF
- STL
2 stops9h 07m
United Airlines
Mon 6/295:10 am
STL
- SAF
1 stop5h 34m
United Airlines
Deal found 6/22![United Airlines logo]()
$499
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/221:22 pm
SAF
- STL
2 stops9h 07m
United Airlines
Mon 6/294:48 pm
STL
- SAF
1 stop4h 53m
United Airlines
Deal found 6/21![United Airlines logo]()
$518
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/110:30 am
SAF
- STL
2 stops9h 59m
United Airlines
Sat 7/111:38 pm
STL
- SAF
1 stop4h 34m
United Airlines
Deal found 6/18![United Airlines logo]()
$532
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/143:20 pm
SAF
- STL
1 stop4h 14m
United Airlines
Tue 11/171:39 pm
STL
- SAF
1 stop4h 31m
United Airlines
Deal found 6/20![United Airlines logo]()
$535
Best flights from Santa Fe to St. LouisDiscover carefully curated flight deals from Santa Fe to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 23, 2026.
Discover carefully curated flight deals from Santa Fe to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 23, 2026.
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:22 pm
SAF
- STL
1 stop6h 21m
United Airlines
Sat 7/115:10 am
STL
- SAF
1 stop5h 34m
United Airlines
Deal found 6/22![United Airlines logo]()
$414
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:00 pm
SAF
- STL
1 stop4h 47m
United Airlines
Fri 7/245:10 am
STL
- SAF
1 stop5h 34m
United Airlines
Deal found 6/18![United Airlines logo]()
$489
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/143:20 pm
SAF
- STL
1 stop4h 14m
United Airlines
Tue 11/171:39 pm
STL
- SAF
1 stop4h 31m
United Airlines
Deal found 6/20![United Airlines logo]()
$535
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:00 pm
SAF
- STL
1 stop4h 57m
United Airlines
Sun 7/51:38 pm
STL
- SAF
1 stop4h 34m
United Airlines
Deal found 6/18![United Airlines logo]()
$635
Last-minute flights from Santa Fe to St. LouisDiscover last-minute flight deals from Santa Fe to St. Louis. Data last updated June 23, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Fe to St. Louis. Data last updated June 23, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/221:22 pm
SAF
- STL
2 stops9h 07m
United Airlines
Mon 6/294:48 pm
STL
- SAF
1 stop4h 53m
United Airlines
Deal found 6/21![United Airlines logo]()
$518
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/265:13 pm
SAF
- STL
1 stop5h 46m
American Airlines
Mon 6/297:04 am
STL
- SAF
1 stop6h 21m
American Airlines
Deal found 6/21![American Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/261:22 pm
SAF
- STL
2 stops9h 07m
United Airlines
Mon 6/295:10 am
STL
- SAF
1 stop5h 34m
United Airlines
Deal found 6/22![United Airlines logo]()
$499
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:13 pm
SAF
- STL
1 stop5h 46m
American Airlines
Sat 7/112:46 pm
STL
- SAF
1 stop5h 10m
American Airlines
Deal found 6/18![American Airlines logo]()
$435
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/110:30 am
SAF
- STL
2 stops9h 59m
United Airlines
Sat 7/111:38 pm
STL
- SAF
1 stop4h 34m
United Airlines
Deal found 6/18![United Airlines logo]()
$532
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:00 pm
SAF
- STL
1 stop4h 57m
United Airlines
Sun 7/51:38 pm
STL
- SAF
1 stop4h 34m
United Airlines
Deal found 6/18![United Airlines logo]()
$577
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:00 pm
SAF
- STL
1 stop4h 57m
United Airlines
Sun 7/51:38 pm
STL
- SAF
1 stop4h 34m
United Airlines
Deal found 6/18![United Airlines logo]()
$635
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:22 pm
SAF
- STL
1 stop6h 21m
United Airlines
Sat 7/115:10 am
STL
- SAF
1 stop5h 34m
United Airlines
Deal found 6/22![United Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:23 pm
SAF
- STL
1 stop5h 41m
American Airlines
Thu 7/232:46 pm
STL
- SAF
1 stop5h 10m
American Airlines
Deal found 6/20![American Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:00 pm
SAF
- STL
1 stop4h 47m
United Airlines
Fri 7/245:10 am
STL
- SAF
1 stop5h 34m
United Airlines
Deal found 6/18![United Airlines logo]()
$489
One-way flights from Santa Fe to St. LouisSearch for one-way flight options from Santa Fe to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 23, 2026.
Search for one-way flight options from Santa Fe to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 23, 2026.
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/26:51 am
SAF
- STL
1 stop6h 02m
American Airlines
Deal found 6/21![American Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:13 pm
SAF
- STL
1 stop5h 46m
American Airlines
Deal found 6/20![American Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:51 am
SAF
- STL
1 stop6h 01m
American Airlines
Deal found 6/21![American Airlines logo]()
$523
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:22 pm
SAF
- STL
2 stops9h 07m
United Airlines
Deal found 6/21![United Airlines logo]()
$614
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/281:22 pm
SAF
- STL
2 stops9h 07m
United Airlines
Deal found 6/21![United Airlines logo]()
$695
Find flight deals from Santa Fe to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $393 (American Airlines) |
One-way from | $345 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Fe to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 23, 2026.
Use the filters below to find and compare flights from Santa Fe to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Tue 7/7
1:22 pm-8:43 pm
1 stop6h 21m
Lambert-St Louis
Sat 7/11
5:10 am-9:44 am
1 stop5h 34m
$414
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Sat 7/18
6:00 pm-11:47 pm
1 stop4h 47m
Lambert-St Louis
Fri 7/24
5:10 am-9:44 am
1 stop5h 34m
$489
Quickest round-trip
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Sat 11/14
3:20 pm-8:34 pm
1 stop4h 14m
Lambert-St Louis
Tue 11/17
1:39 pm-5:10 pm
1 stop4h 31m
$535
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Thu 7/2
6:00 pm-11:57 pm
1 stop4h 57m
Lambert-St Louis
Sun 7/5
1:38 pm-5:12 pm
1 stop4h 34m
$635
Cheapest one-way
Quickest one-way
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Fri 7/3
6:51 am-1:52 pm
1 stop6h 01m
$523
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Fri 7/3
1:22 pm-11:29 pm
2 stops9h 07m
$614
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Sun 6/28
7:05 am-6:13 pm
2 stops10h 08m
$695
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Sun 8/2
10:30 am-11:44 pm
2 stops12h 14m
$695
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Santa Fe-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Fe-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Fe to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santa Fe with our price prediction graph.
SAF-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 23, 2026.
See what other customers who have flown with American Airlines from Santa Fe to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Boarding
7.5
Comfort
7.2
Overall
7.1
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Crew
7.9
Food
6.4
Boarding
7.5
Comfort
7.2
Overall
7.1
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Related info for your journey
Find useful and relevant information for your journey from Santa Fe to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Santa Fe
Popular flights
St. Louis flight routes
Alternative routes for Santa Fe to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Santa Fe to St. Louis by cabin class
Find flights from Santa Fe to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Santa Fe and St. Louis flights
Browse other Santa Fe and St. Louis flight options. Last updated on June 23, 2026.
Other flights from Santa Fe
Browse through other flights departing from Santa Fe. Flights are based on user searches made on Cheapflights and were last updated on June 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 23, 2026.
Top airline flying from Santa Fe to St. Louis
Discover the top airline that operate flights from Santa Fe to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$319 | Average$398 | FlexibilityNo cancel fee | On-time71% |