$197+ Cheap flights from Santa Fe to St. Louis (SAF - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — STL
Sep 3 — Sep 101
Round-trip
1 adult, Economy
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Find cheap flights from Santa Fe to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
One-way
Cheapest flights from Santa Fe to St. LouisExplore the most affordable flight options available from Santa Fe to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
Explore the most affordable flight options available from Santa Fe to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:48 am
SAF
- STL
1 stop8h 32m
American Airlines
Mon 9/75:42 am
STL
- SAF
1 stop4h 59m
American Airlines
Deal found 8/3![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/184:53 pm
SAF
- STL
1 stop5h 49m
American Airlines
Sat 8/228:36 am
STL
- SAF
1 stop6h 02m
American Airlines
Deal found 8/3![American Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:48 am
SAF
- STL
1 stop5h 07m
American Airlines
Wed 8/1910:16 am
STL
- SAF
1 stop7h 07m
American Airlines
Deal found 7/30![American Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:21 pm
SAF
- STL
1 stop4h 25m
United Airlines
Sat 8/294:40 pm
STL
- SAF
1 stop4h 56m
United Airlines
Deal found 8/2![United Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1112:35 pm
SAF
- STL
1 stop7h 17m
American Airlines
Fri 9/185:18 pm
STL
- SAF
1 stop5h 39m
American Airlines
Deal found 8/3![American Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:00 pm
SAF
- STL
1 stop4h 40m
United Airlines
Wed 8/194:40 pm
STL
- SAF
1 stop4h 56m
United Airlines
Deal found 7/31![United Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:00 am
SAF
- STL
1 stop5h 04m
American Airlines
Fri 11/138:13 pm
STL
- SAF
1 stop17h 11m
American Airlines
Deal found 8/3![American Airlines logo]()
$486
Best flights from Santa Fe to St. LouisDiscover carefully curated flight deals from Santa Fe to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
Discover carefully curated flight deals from Santa Fe to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:00 am
SAF
- STL
1 stop4h 38m
United Airlines
Sat 11/71:40 pm
STL
- SAF
1 stop4h 32m
United Airlines
Deal found 8/3![United Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:16 pm
SAF
- STL
1 stop5h 06m
American Airlines
Fri 11/138:13 pm
STL
- SAF
1 stop17h 11m
American Airlines
Deal found 8/1![American Airlines logo]()
$496
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:21 pm
SAF
- STL
1 stop4h 25m
United Airlines
Sat 8/299:00 am
STL
- SAF
1 stop4h 47m
United Airlines
Deal found 7/31![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:00 pm
SAF
- STL
1 stop4h 40m
United Airlines
Wed 8/194:40 pm
STL
- SAF
1 stop4h 56m
United Airlines
Deal found 7/31![United Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:16 pm
SAF
- STL
1 stop7h 58m
American Airlines
Fri 11/138:13 pm
STL
- SAF
1 stop17h 11m
American Airlines
Deal found 7/31![American Airlines logo]()
$496
Last-minute flights from Santa Fe to St. LouisDiscover last-minute flight deals from Santa Fe to St. Louis. Data last updated August 4, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Fe to St. Louis. Data last updated August 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:48 am
SAF
- STL
1 stop5h 07m
American Airlines
Wed 8/1910:16 am
STL
- SAF
1 stop7h 07m
American Airlines
Deal found 7/30![American Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:00 pm
SAF
- STL
1 stop4h 40m
United Airlines
Wed 8/194:40 pm
STL
- SAF
1 stop4h 56m
United Airlines
Deal found 7/31![United Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/184:53 pm
SAF
- STL
1 stop5h 49m
American Airlines
Sat 8/228:36 am
STL
- SAF
1 stop6h 02m
American Airlines
Deal found 8/3![American Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:21 pm
SAF
- STL
1 stop4h 25m
United Airlines
Sat 8/294:40 pm
STL
- SAF
1 stop4h 56m
United Airlines
Deal found 8/2![United Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:48 am
SAF
- STL
1 stop8h 32m
American Airlines
Mon 9/75:42 am
STL
- SAF
1 stop4h 59m
American Airlines
Deal found 8/3![American Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:21 pm
SAF
- STL
1 stop4h 25m
United Airlines
Mon 9/75:30 pm
STL
- SAF
2 stops16h 55m
United Airlines
Deal found 8/3![United Airlines logo]()
$567
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1112:35 pm
SAF
- STL
1 stop7h 17m
American Airlines
Fri 9/185:18 pm
STL
- SAF
1 stop5h 39m
American Airlines
Deal found 8/3![American Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:50 pm
SAF
- STL
1 stop4h 50m
United Airlines
Fri 9/185:30 pm
STL
- SAF
2 stops17h 16m
United Airlines
Deal found 8/3![United Airlines logo]()
$551
One-way flights from Santa Fe to St. LouisSearch for one-way flight options from Santa Fe to St. Louis. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
Search for one-way flight options from Santa Fe to St. Louis. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:38 pm
SAF
- STL
1 stop6h 05m
American Airlines
Deal found 7/31![American Airlines logo]()
$197
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:22 pm
SAF
- STL
1 stop6h 16m
United Airlines
Deal found 7/31![United Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:48 am
SAF
- STL
1 stop8h 32m
American Airlines
Deal found 7/31![American Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:22 pm
SAF
- STL
2 stops8h 37m
United Airlines
Deal found 7/31![United Airlines logo]()
$305
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:10 am
SAF
- STL
2 stops14h 49m
United Airlines
Deal found 7/31![United Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:22 pm
SAF
- STL
2 stops8h 37m
United Airlines
Deal found 7/31![United Airlines logo]()
$355
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:50 pm
SAF
- STL
2 stops17h 07m
United Airlines
Deal found 7/31![United Airlines logo]()
$361
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:00 pm
SAF
- STL
2 stops20h 44m
United Airlines
Deal found 7/31![United Airlines logo]()
$449
Find flight deals from Santa Fe to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $314 (American Airlines) |
One-way from | $197 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Fe to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from Santa Fe to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Tue 10/27
7:00 am-12:38 pm
1 stop4h 38m
Lambert-St Louis
Sat 11/7
1:40 pm-5:12 pm
1 stop4h 32m
$394
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Tue 8/25
3:21 pm-8:46 pm
1 stop4h 25m
Lambert-St Louis
Sat 8/29
9:00 am-12:47 pm
1 stop4h 47m
$394
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Sat 8/15
6:00 pm-11:40 pm
1 stop4h 40m
Lambert-St Louis
Wed 8/19
4:40 pm-8:36 pm
1 stop4h 56m
$424
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Thu 11/12
1:16 pm-7:22 pm
1 stop5h 06m
Lambert-St Louis
Fri 11/13
8:13 pm-12:24 pm
1 stop17h 11m
$496
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Wed 11/11
1:16 pm-10:14 pm
1 stop7h 58m
Lambert-St Louis
Fri 11/13
8:13 pm-12:24 pm
1 stop17h 11m
$496
Cheapest one-way
Quickest one-way
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Sun 9/6
6:00 pm-11:31 pm
1 stop4h 31m
$237
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Sat 9/12
10:30 am-10:59 pm
2 stops11h 29m
$247
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Fri 9/11
1:22 pm-10:59 pm
2 stops8h 37m
$305
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Tue 9/8
5:50 pm-11:57 am
2 stops17h 07m
$361
Santa FeSt. Louis
SAF - STL
SAFSTL
Santa Fe
Mon 9/7
6:00 pm-3:44 pm
2 stops20h 44m
$449
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Santa Fe-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Fe-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Fe to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santa Fe with our price prediction graph.
SAF-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated August 4, 2026.
See what other customers who have flown with American Airlines from Santa Fe to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.1
Food
6.4
Boarding
7.5
Crew
7.9
Entertainment
6.8
Comfort
7.2
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Overall
7.1
Food
6.4
Boarding
7.5
Crew
7.9
Entertainment
6.8
Comfort
7.2
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Santa Fe to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
Fairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Farmington
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Santa Fe and St. Louis flights
Browse other Santa Fe and St. Louis flight options. Last updated on August 4, 2026.
Other flights from Santa Fe
Browse through other flights departing from Santa Fe. Flights are based on user searches made on Cheapflights and were last updated on August 4, 2026.
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Top airline flying from Santa Fe to St. Louis
Discover the top airline that operate flights from Santa Fe to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$319 | Average$364 | FlexibilityNo cancel fee | On-time71% |