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$264+ Cheap flights from Santa Fe to St. Louis (SAF - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — STL
Aug 20 — Aug 271
Thu 8/20
Thu 8/27
1 adult, Economy
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Cheap flight deals from Santa Fe to St. Louis

Cheapest flights from Santa Fe to St. Louis
Explore the most affordable flight options available from Santa Fe to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 21, 2026.

This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/194:53 pm
SAF
-
STL
1 stop5h 49m
American Airlines
Wed 8/268:36 am
STL
-
SAF
1 stop6h 02m
American Airlines
Deal found 7/19$304
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/191:22 pm
SAF
-
STL
1 stop6h 24m
United Airlines
Wed 8/267:25 am
STL
-
SAF
2 stops10h 46m
United Airlines
Deal found 7/19$394
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/54:53 pm
SAF
-
STL
1 stop5h 49m
American Airlines
Sun 8/95:42 am
STL
-
SAF
1 stop4h 59m
American Airlines
Deal found 7/21$408
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/51:22 pm
SAF
-
STL
2 stops9h 22m
United Airlines
Sun 8/99:06 am
STL
-
SAF
1 stop6h 38m
United Airlines
Deal found 7/21$640
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1810:30 am
SAF
-
STL
2 stops10h 06m
United Airlines
Sun 9/205:10 am
STL
-
SAF
1 stop5h 36m
United Airlines
Deal found 7/19$695

Find flight deals from Santa Fe to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$304
(American Airlines)

One-way from

$264
(American Airlines)
Provider with most accurate pricing for Santa Fe-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Santa Fe-Lambert-St Louis flights.
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From Santa Fe to Lambert-St Louis
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One-way flight from Santa Fe to Lambert-St Louis
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 21, 2026.
Use the filters below to find and compare flights from Santa Fe to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Wed 8/19

1:22 pm-8:46 pm

1 stop6h 24m

Lambert-St Louis

Wed 8/26

7:25 am-5:11 pm

2 stops10h 46m

$394
Quickest round-trip

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Wed 8/5

4:53 pm-11:42 pm

1 stop5h 49m

Lambert-St Louis

Sun 8/9

5:42 am-9:41 am

1 stop4h 59m

$408

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Wed 8/5

1:22 pm-11:44 pm

2 stops9h 22m

Lambert-St Louis

Sun 8/9

9:06 am-2:44 pm

1 stop6h 38m

$640

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Fri 9/18

10:30 am-9:36 pm

2 stops10h 06m

Lambert-St Louis

Sun 9/20

5:10 am-9:46 am

1 stop5h 36m

$695
Cheapest one-way

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Tue 8/25

10:30 am-10:00 pm

2 stops10h 30m

$274
Quickest one-way

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Sat 8/1

11:20 am-7:53 pm

1 stop7h 33m

$359

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Sat 8/1

10:30 am-11:44 pm

2 stops12h 14m

$369

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Wed 7/29

10:30 am-11:44 pm

2 stops12h 14m

$402

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Sun 7/26

3:22 pm-11:57 pm

1 stop7h 35m

$414

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Thu 7/30

10:30 am-11:44 pm

2 stops12h 14m

$424

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/16

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Santa Fe-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Fe-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Fe to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated July 21, 2026.
See what other customers who have flown with American Airlines from Santa Fe to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,826 reviews

Food

6.4

Comfort

7.2

Crew

7.9

Overall

7.1

Entertainment

6.8

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,826 reviews
American Airlines
7.1
Good
11,826 reviews

Food

6.4

Comfort

7.2

Crew

7.9

Overall

7.1

Entertainment

6.8

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to St. Louis?

    United Airlines and American Airlines can get you from Santa Fe to St. Louis in just under 5h 49m. Your travel time can differ by up to 35m. There are 890 mi between Santa Fe and St. Louis. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Santa Fe to St. Louis round-trip?

    Cheapflights users have booked flights from Santa Fe to St. Louis round-trip from $319.

  • Can I find deals for flights from Santa Fe to St. Louis that include hotel bookings?

    Yes. In addition to deals on Santa Fe to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to St. Louis.

  • Can I find deals for business class flights from Santa Fe to St. Louis?

    Yes. Cheapflights offers flight deals from Santa Fe to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Farmington

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Santa Fe to St. Louis

Discover the top airline that operate flights from Santa Fe to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$319Average$364FlexibilityNo cancel feeOn-time71%

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