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$438+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
déc. 20 — déc. 271
sam. 12/20
sam. 12/27
1 adult, Economy
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Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on novembre 20, 2025.

This Air Europa deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/279:30 pmPTY - MAD
Nonstop9h 35mAir Europa
lun. 12/83:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/19$684
This Air France deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 12/2410:20 pmPTY - MAD
1 stop14h 50mMultiple Airlines
sam. 2/75:00 pmMAD - PTY
1 stop29h 30mMultiple Airlines
Deal found 11/17$696
This Avianca deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 11/292:55 amPTY - MAD
1 stop14h 25mAvianca
jeu. 2/261:20 amMAD - PTY
1 stop18h 40mAvianca
Deal found 11/18$700
This Trip.com deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/99:30 pmPTY - MAD
Nonstop9h 35mAir Europa
ven. 12/193:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/19$709
This Gotogate deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 11/309:30 pmPTY - MAD
Nonstop9h 35mAir Europa
ven. 2/273:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/18$740
This Avianca deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/232:55 amPTY - MAD
1 stop14h 25mAvianca
sam. 2/76:40 amMAD - PTY
1 stop24h 20mAvianca
Deal found 11/17$742
This Air Europa deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 11/299:30 pmPTY - VLC
1 stop28h 35mAir Europa
lun. 12/1512:25 pmVLC - PTY
1 stop13h 20mAir Europa
Deal found 11/19$750
This Booking.com deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 11/266:20 pmPTY - MAD
Nonstop10h 05mIberia
mer. 12/3111:40 amMAD - PTY
Nonstop11h 05mIberia
Deal found 11/19$796
This KLM deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 12/256:40 pmPTY - BCN
2 stops16h 25mMultiple Airlines
lun. 2/910:05 amBCN - PTY
1 stop15h 50mMultiple Airlines
Deal found 11/20$798
This Avianca deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 12/255:50 pmPTY - MAD
1 stop13h 35mAvianca
mar. 3/31:20 amMAD - PTY
1 stop13h 30mAvianca
Deal found 11/18$828
This KLM deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/206:45 pmPTY - BCN
1 stop18h 20mMultiple Airlines
mer. 12/34:00 pmBCN - PTY
1 stop34h 10mMultiple Airlines
Deal found 11/19$938
This Mytrip deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/207:05 pmPTY - BCN
3 stops32h 05mMultiple Airlines
dim. 11/239:45 pmBCN - PTY
2 stops28h 00mMultiple Airlines
Deal found 11/19$942

Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated novembre 20, 2025.

Round-trip from

$684
(Air Europa)

One-way from

$438
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$818

Good round-trip deal

$810 or less

Good one-way deal

$635 or less
From Panama City Tocumen Intl to Spain
Search Deals
One-way flight from Panama City Tocumen Intl to Spain
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($32 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated novembre 20, 2025.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

lun. 2/2

10:05 pm-10:15 am

1 stop30h 10m

Madrid Barajas

lun. 2/16

11:00 am-7:55 pm

1 stop14h 55m

$695

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

mar. 2/3

6:45 pm-5:10 pm

1 stop40h 25m

Valencia

dim. 2/8

6:10 pm-5:05 pm

2 stops28h 55m

$750

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

mer. 2/4

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

mer. 2/18

2:25 pm-5:05 pm

2 stops32h 40m

$760

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

lun. 4/20

8:25 pm-4:15 pm

1 stop12h 50m

Malaga

ven. 4/24

8:35 am-6:40 pm

1 stop17h 05m

$775

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

mer. 1/21

9:45 pm-5:10 pm

1 stop37h 25m

Valencia

ven. 2/20

11:55 am-7:50 pm

1 stop37h 55m

$802

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

lun. 4/20

10:15 pm-4:50 pm

1 stop35h 35m

Malaga

ven. 4/24

5:50 pm-6:30 pm

2 stops31h 40m

$803

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

dim. 1/25

9:30 pm-4:15 pm

1 stop12h 45m

Valencia

mar. 2/24

12:25 pm-7:45 pm

1 stop13h 20m

$807

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

sam. 1/24

9:30 pm-4:15 pm

1 stop12h 45m

Valencia

lun. 2/23

12:25 pm-7:45 pm

1 stop13h 20m

$807

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

dim. 2/8

6:45 pm-11:40 am

1 stop34h 55m

Malaga

dim. 2/15

5:40 pm-7:50 pm

1 stop32h 10m

$807

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

ven. 2/6

6:45 pm-11:00 pm

1 stop22h 15m

Valencia

ven. 3/6

9:55 am-4:30 pm

1 stop36h 35m

$814

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/20

Showing 1-10 of 60 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in September is currently the most expensive (average of $650). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated novembre 20, 2025.

It’s optimal to fly from Panama City to Spain in the evening. By choosing this option you can save up to 18% on the cost of your flight, compared to a flight at noon.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated novembre 20, 2025.

The most flights from PTY to ES0 are scheduled on a Monday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

How often are flights $[0, preposition:'from ']$[0, article:'from ']$[0, place:'from'] $[1, preposition:'to ']$[1, article:'to ']$[1, place:'to'] delayed?

About 14% of weekly flights between $[0, place:'genitive'] and $[1, place:'genitive'] have experienced delays in the past year, with the average delay time being 132 minutes.

What is the most punctual flight time for $[0,article:'genitive ']$[0,place:'genitive'] $[1, preposition:'to ']$[1, article:'to ']$[1, place:'to'] flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.

Which airline has the best punctuality record on $[0,article:'genitive ']$[0,place:'genitive'] $[1, preposition:'to ']$[1, article:'to ']$[1, place:'to'] flights?

Over the last year, Pascan have had the lowest number of delays on this route, with just 6% of flights being delayed.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated novembre 20, 2025.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Air Europa from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,493 reviews

Overall

7.4

Entertainment

7.0

Boarding

7.4

Crew

8.2

Food

7.0

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Air France
7.4
Good
1,493 reviews
Air France
7.4
Good
1,493 reviews

Overall

7.4

Entertainment

7.0

Boarding

7.4

Crew

8.2

Food

7.0

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Turkish Airlines
7.3
Good
4,044 reviews
Air France
7.4
Good
1,493 reviews

Overall

7.4

Entertainment

7.0

Boarding

7.4

Crew

8.2

Food

7.0

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Air Europa
7.0
Good
569 reviews
Air France
7.4
Good
1,493 reviews

Overall

7.4

Entertainment

7.0

Boarding

7.4

Crew

8.2

Food

7.0

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Iberia
7.0
Good
3,027 reviews
Air France
7.4
Good
1,493 reviews

Overall

7.4

Entertainment

7.0

Boarding

7.4

Crew

8.2

Food

7.0

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Avianca
6.6
Okay
2,477 reviews
Air France
7.4
Good
1,493 reviews

Overall

7.4

Entertainment

7.0

Boarding

7.4

Crew

8.2

Food

7.0

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 19 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Spain?

    KLM, Turkish Airlines, and Air Europa can get you from Panama City to Spain in just under 28h 35m. Your travel time can differ by up to 11h 50m. Panama City and Spain are separated by a distance of 5227 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Air Europa, which is currently one of the cheapest options available, starting at $541. KLM flights start at $543 while deals on Avianca start at $546 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Valencia when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Air Europa (78%), Etihad Airways (78%) or China Eastern (78%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $858 for a flight from Panama City to Spain. The cheapest flight overall is $526 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $684.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in September is currently the most expensive (average of $650). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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Top 8 airlines flying from Panama City to Spain

Discover the top 8 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated novembre 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$614Average$960FlexibilityNo cancel feeOn-time71%
KLMCheapest$654Average$938FlexibilityNo cancel feeOn-time75%
Air EuropaCheapest$661Average$850FlexibilityNo cancel feeOn-time83%
IberiaCheapest$677Average$852FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$697Average$823FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$781FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$854FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$728Average$1,232FlexibilityNo cancel feeOn-time70%

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