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$449+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated August 14, 2025.

Round-trip from

$714
(CheapOair)

One-way from

$449
(Turkish Airlines)

Popular in

January

Cheapest in

March

Average price

$879

Good round-trip deal

$824 or less

Good one-way deal

$624 or less
From Panama City Tocumen Intl to Spain
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One-way flight from Panama City Tocumen Intl to Spain
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Highest demand for flights based on searches. 4% potential increase in price ($36 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
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Find flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This CheapOair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/289:55 pmPTY - BCN
1 stop29h 40mTurkish Airlines
Thu 10/2312:00 pmBCN - PTY
1 stop39h 00mTurkish Airlines
Deal found 8/13$714
This CheapOair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Sun 11/233:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/13$716
This KLM deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/146:50 pmPTY - MAD
1 stop17h 40mKLM
Sun 9/76:00 amMAD - PTY
1 stop17h 50mKLM
Deal found 8/14$717
This KLM deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/136:50 pmPTY - MAD
1 stop34h 15mKLM
Tue 9/25:10 pmMAD - PTY
1 stop30h 40mKLM
Deal found 8/13$718
This CheapOair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/219:55 pmPTY - MAD
1 stop32h 40mTurkish Airlines
Sat 10/46:20 pmMAD - PTY
1 stop32h 40mTurkish Airlines
Deal found 8/13$719
This Avianca deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:55 amPTY - MAD
1 stop14h 25mAvianca
Wed 11/51:20 amMAD - PTY
1 stop13h 30mAvianca
Deal found 8/14$720
This Air Europa deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/288:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Tue 10/73:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/14$721
This Air Europa deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/308:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Tue 10/143:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/13$722
This Avianca deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/263:25 amPTY - MAD
1 stop13h 05mAvianca
Sun 10/59:40 amMAD - PTY
1 stop18h 30mAvianca
Deal found 8/14$729
This Mytrip deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1411:05 amPTY - BCN
2 stops17h 20mMultiple Airlines
Wed 8/207:00 amBCN - PTY
2 stops26h 40mMultiple Airlines
Deal found 8/13$730
This Air Europa deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/58:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Fri 10/243:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/13$735
This CheapOair deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/128:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Tue 10/283:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 8/14$736

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Sun 9/28

9:55 pm-5:05 pm

1 stop36h 10m

Barcelona-El Prat

Thu 10/23

12:00 pm-8:00 pm

1 stop39h 00m

$714

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Sun 9/28

9:55 pm-11:10 pm

1 stop18h 15m

Barcelona-El Prat

Wed 10/22

7:50 am-8:00 pm

1 stop19h 10m

$714

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Wed 10/1

9:55 pm-5:05 pm

1 stop36h 10m

Barcelona-El Prat

Sun 10/12

7:50 am-8:00 pm

1 stop19h 10m

$714

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 9/25

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Mon 10/6

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 9/28

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Mon 10/6

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 9/30

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Mon 10/6

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 9/28

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Tue 10/7

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 9/30

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Tue 10/7

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 9/29

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Wed 10/8

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 9/28

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Wed 10/8

3:05 pm-6:40 pm

Nonstop10h 35m

$721

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 60 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,053). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 14, 2025.

The most flights from PTY to ES0 are scheduled on a Thursday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated August 14, 2025.
Get a feel of what it's like to fly with KLM, Air France, and Air Europa from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,381 reviews

Overall

7.8

Boarding

7.8

Crew

8.4

Food

7.3

Comfort

7.7

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
KLM
7.8
Good
1,381 reviews
KLM
7.8
Good
1,381 reviews

Overall

7.8

Boarding

7.8

Crew

8.4

Food

7.3

Comfort

7.7

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Air France
7.4
Good
1,467 reviews
KLM
7.8
Good
1,381 reviews

Overall

7.8

Boarding

7.8

Crew

8.4

Food

7.3

Comfort

7.7

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Air Europa
7.0
Good
545 reviews
KLM
7.8
Good
1,381 reviews

Overall

7.8

Boarding

7.8

Crew

8.4

Food

7.3

Comfort

7.7

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Iberia
7.0
Good
2,878 reviews
KLM
7.8
Good
1,381 reviews

Overall

7.8

Boarding

7.8

Crew

8.4

Food

7.3

Comfort

7.7

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Avianca
6.7
Okay
2,401 reviews
KLM
7.8
Good
1,381 reviews

Overall

7.8

Boarding

7.8

Crew

8.4

Food

7.3

Comfort

7.7

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 16 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Turkish Airlines, which is currently one of the cheapest options available, starting at $449. Air Europa flights start at $835 while deals on United Airlines start at $920 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Malaga when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Qatar Airways (100%), Hainan Airlines (100%) or EL AL (97%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,507 for a flight from Panama City to Spain. The cheapest flight overall is $508 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $684.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,053). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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Top 8 airlines flying from Panama City to Spain

Discover the top 8 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$543Average$868FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$665Average$846FlexibilityNo cancel feeOn-time83%
Air FranceCheapest$674Average$805FlexibilityNo cancel feeOn-time77%
IberiaCheapest$678Average$952FlexibilityNo cancel feeOn-time77%
KLMCheapest$681Average$898FlexibilityNo cancel feeOn-time75%
Turkish AirlinesCheapest$698Average$792FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$821FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$826Average$1,190FlexibilityNo cancel feeOn-time70%

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