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$435+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated June 12, 2025.

Round-trip from

$715
(Air France)

One-way from

$435
(Turkish Airlines)

Popular in

July

Cheapest in

March

Average price

$871

Good round-trip deal

$841 or less

Good one-way deal

$640 or less
From Panama City Tocumen Intl to Spain
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One-way flight from Panama City Tocumen Intl to Spain
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Highest demand for flights based on searches. 6% potential increase in price ($57 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
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Find flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Air France deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/37:55 pmPTY - MAD
1 stop13h 50mMultiple Airlines
Thu 8/215:10 pmMAD - PTY
1 stop30h 40mMultiple Airlines
Deal found 6/10$715
This Air France deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/37:55 pmPTY - MAD
1 stop13h 50mAir France
Thu 8/216:00 amMAD - PTY
1 stop18h 45mAir France
Deal found 6/12$716
This Air Europa deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/38:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Fri 8/223:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 6/10$724
This CheapOair deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/11:30 pmPTY - MAD
2 stops17h 55mAvianca
Sat 11/158:30 amMAD - PTY
2 stops34h 05mAvianca
Deal found 6/10$739
This Turkish Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/179:55 pmPTY - MAD
1 stop32h 40mTurkish Airlines
Tue 9/306:20 pmMAD - PTY
1 stop32h 40mTurkish Airlines
Deal found 6/10$740
This KLM deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/186:50 pmPTY - MAD
1 stop21h 35mKLM
Fri 8/298:25 pmMAD - PTY
1 stop27h 25mKLM
Deal found 6/10$749
This Turkish Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/19:45 pmPTY - AGP
1 stop31h 55mTurkish Airlines
Fri 12/1212:40 pmAGP - PTY
1 stop37h 10mTurkish Airlines
Deal found 6/12$750
This Turkish Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/149:55 pmPTY - BCN
1 stop29h 40mTurkish Airlines
Wed 9/247:50 amBCN - PTY
1 stop19h 10mTurkish Airlines
Deal found 6/10$762
This Turkish Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/169:55 pmPTY - VLC
1 stop36h 30mTurkish Airlines
Thu 7/246:20 pmVLC - PTY
1 stop32h 40mTurkish Airlines
Deal found 6/12$774
This Booking.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:20 pmPTY - MAD
Nonstop10h 05mIberia
Sat 11/1511:45 amMAD - PTY
Nonstop11h 05mIberia
Deal found 6/10$778
This Gotogate deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/68:25 pmPTY - BCN
1 stop29h 30mAir Europa
Mon 10/2011:50 amBCN - PTY
1 stop13h 50mAir Europa
Deal found 6/10$799
This KLM deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:50 pmPTY - BCN
1 stop30h 45mKLM
Mon 9/295:20 pmBCN - PTY
1 stop30h 30mKLM
Deal found 6/10$821

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 7/3

7:55 pm-4:45 pm

1 stop13h 50m

Madrid Barajas

Thu 8/21

5:10 pm-4:50 pm

1 stop30h 40m

$715

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 7/3

7:55 pm-4:45 pm

1 stop13h 50m

Madrid Barajas

Thu 8/21

6:00 am-5:45 pm

1 stop18h 45m

$716

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 8/3

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Sun 8/24

3:05 pm-6:40 pm

Nonstop10h 35m

$724

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 11/1

1:30 pm-1:25 pm

2 stops17h 55m

Madrid Barajas

Sat 11/15

8:30 am-12:35 pm

2 stops34h 05m

$739

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 10/24

9:55 pm-11:25 am

1 stop30h 30m

Madrid Barajas

Tue 11/11

11:55 am-7:50 pm

1 stop37h 55m

$740

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 7/18

6:50 pm-11:25 pm

1 stop21h 35m

Madrid Barajas

Fri 8/29

8:25 pm-4:50 pm

1 stop27h 25m

$749

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Mon 12/1

9:45 pm-11:40 am

1 stop31h 55m

Malaga

Fri 12/12

12:40 pm-7:50 pm

1 stop37h 10m

$750

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Sun 9/14

9:55 pm-10:35 am

1 stop29h 40m

Barcelona-El Prat

Wed 9/24

7:50 am-8:00 pm

1 stop19h 10m

$762

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Wed 7/16

9:55 pm-5:25 pm

1 stop36h 30m

Valencia

Thu 7/24

6:20 pm-8:00 pm

1 stop32h 40m

$774

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 11/3

6:20 pm-10:25 am

Nonstop10h 05m

Madrid Barajas

Sat 11/15

11:45 am-4:50 pm

Nonstop11h 05m

$778

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 52 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,057). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 12, 2025.

The most flights from PTY to ES0 are scheduled on a Saturday (9 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (3 on average).

Rainfall in Spain by month

Plan your trip to Spain by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Spain ranges from 0.8 - 3.6 inches per month. October is typically the wettest month, when rainfall can reach 3.6 in. July is typically the driest time to visit Spain when rainfall is around 0.8 in.

Temperature in Spain by month

Plan your trip to Spain by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Spain, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated June 12, 2025.
See what other customers who have flown with Delta, KLM and Air France from Panama City to Spain have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
KLM
7.8
Good
1,358 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
Air France
7.5
Good
1,463 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
Copa Airlines
7.5
Good
1,451 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 17 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Turkish Airlines, which is currently one of the cheapest options available, starting at $435. KLM flights start at $507 while deals on Air Europa start at $511 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Granadilla Tenerife-Sur when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Air Europa (88%), Etihad Airways (88%) or China Eastern (88%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,574 for a flight from Panama City to Spain. The cheapest flight overall is $534 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $706.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,057). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 7 airlines flying from Panama City to Spain

Discover the top 7 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$543Average$862FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$666Average$840FlexibilityNo cancel feeOn-time83%
KLMCheapest$670Average$883FlexibilityNo cancel feeOn-time75%
Air FranceCheapest$674Average$799FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$678Average$816FlexibilityNo cancel feeOn-time69%
IberiaCheapest$680Average$954FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$729Average$804FlexibilityNo cancel feeOn-time77%

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