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$550+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Apr 20 — Apr 271
Mon 4/20
Mon 4/27
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 21, 2026.

This Avianca deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/23:50 pm
PTY
-
MAD
1 stop25h 20m
Avianca
Thu 8/208:10 am
MAD
-
PTY
1 stop13h 05m
Avianca
Deal found 3/19$677
This Air France deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:27 pm
PTY
-
MAD
1 stop14h 48m
Air France
Fri 5/84:40 pm
MAD
-
PTY
1 stop34h 05m
Air France
Deal found 3/20$678
This Avianca deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:55 pm
PTY
-
MAD
1 stop16h 30m
Avianca
Sat 11/146:40 am
MAD
-
PTY
1 stop13h 20m
Avianca
Deal found 3/18$680
This Avianca deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:25 am
PTY
-
MAD
1 stop13h 55m
Avianca
Sat 10/316:40 am
MAD
-
PTY
1 stop16h 15m
Avianca
Deal found 3/20$682
This Air France deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:27 pm
PTY
-
MAD
1 stop14h 48m
Multiple Airlines
Mon 6/15:20 pm
MAD
-
PTY
1 stop30h 30m
Multiple Airlines
Deal found 3/20$686
This Air France deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:27 pm
PTY
-
MAD
1 stop14h 48m
Air France
Wed 5/136:00 am
MAD
-
PTY
2 stops17h 50m
Air France
Deal found 3/20$687
This Air France deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:27 pm
PTY
-
MAD
1 stop14h 48m
Multiple Airlines
Sun 5/318:30 pm
MAD
-
PTY
1 stop27h 20m
Multiple Airlines
Deal found 3/18$696
This Air France deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:27 pm
PTY
-
MAD
2 stops19h 18m
Multiple Airlines
Sat 5/25:20 pm
MAD
-
PTY
1 stop30h 30m
Multiple Airlines
Deal found 3/19$698
This Air France deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/142:15 pm
PTY
-
MAD
1 stop15h 00m
Air France
Sat 5/235:45 pm
MAD
-
PTY
1 stop33h 00m
Air France
Deal found 3/19$699
This Avianca deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:55 pm
PTY
-
MAD
1 stop16h 30m
Avianca
Sat 11/76:40 am
MAD
-
PTY
1 stop16h 15m
Avianca
Deal found 3/17$702
This Turkish Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2210:20 pm
PTY
-
AGP
1 stop29h 30m
Turkish Airlines
Mon 4/2712:20 pm
AGP
-
PTY
2 stops37h 05m
Turkish Airlines
Deal found 3/17$723
This KLM deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:50 pm
PTY
-
BCN
1 stop32h 25m
KLM
Sun 5/317:45 pm
BCN
-
PTY
1 stop28h 05m
KLM
Deal found 3/20$725

Find flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated March 21, 2026.

Round-trip from

$677
(Avianca)

One-way from

$550
(Avianca)

Popular in

January

Cheapest in

May

Average price

$866

Good round-trip deal

$773 or less

Good one-way deal

$682 or less
From Panama City Tocumen Intl to Spain
Search Deals
One-way flight from Panama City Tocumen Intl to Spain
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($75 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2026.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 5/26

8:05 pm-10:25 am

1 stop31h 20m

Madrid Barajas

Sun 5/31

6:25 pm-8:25 pm

1 stop33h 00m

$721

Panama CityBilbao

PTY - BIO

PTYBIO

Panama City Tocumen Intl

Thu 4/23

8:10 pm-11:10 am

1 stop32h 00m

Bilbao

Sun 5/3

6:20 pm-8:25 pm

1 stop33h 05m

$745

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Sun 5/3

8:05 pm-10:50 am

1 stop31h 45m

Malaga

Sun 6/14

11:50 am-6:30 pm

2 stops37h 40m

$749

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Tue 5/26

6:50 pm-10:10 pm

1 stop20h 20m

Malaga

Wed 6/3

11:05 pm-4:50 pm

1 stop24h 45m

$757

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Wed 4/15

10:20 pm-10:45 am

1 stop29h 25m

Barcelona-El Prat

Wed 4/22

7:40 am-8:25 pm

1 stop19h 45m

$771

Panama CityIbiza

PTY - IBZ

PTYIBZ

Panama City Tocumen Intl

Mon 5/18

8:25 pm-2:05 pm

1 stop34h 40m

Ibiza

Fri 5/22

2:55 pm-6:40 pm

1 stop34h 45m

$777

Panama CitySeville

PTY - SVQ

PTYSVQ

Panama City Tocumen Intl

Sat 5/2

10:20 pm-10:35 am

1 stop29h 15m

Sevilla

Thu 5/7

6:35 pm-6:25 pm

2 stops30h 50m

$784

Panama CityBilbao

PTY - BIO

PTYBIO

Panama City Tocumen Intl

Mon 4/20

10:20 pm-5:20 pm

1 stop36h 00m

Bilbao

Sun 4/26

6:20 pm-6:30 pm

2 stops31h 10m

$798

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Fri 5/22

8:25 pm-7:45 am

1 stop28h 20m

Malaga

Tue 5/26

8:35 am-6:40 pm

1 stop17h 05m

$802

Panama CityVigo

PTY - VGO

PTYVGO

Panama City Tocumen Intl

Thu 6/11

8:25 pm-4:00 pm

1 stop12h 35m

Vigo

Sun 6/14

8:40 am-6:40 pm

1 stop17h 00m

$817

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/19

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
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6

Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in December is currently the most expensive (average of $703). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 21, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated March 21, 2026.

The most flights from PTY to ES0 are scheduled on a Wednesday (10 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (4 on average).

How often are flights from Panama City to Spain delayed?

About 13% of weekly flights between Panama City and Spain have experienced delays in the past year, with the average delay time being 150 minutes.

What is the most punctual flight time for Panama City to Spain flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Sunday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama City to Spain flights?

Over the last year, Air Europa have had the lowest number of delays on this route, with just 11% of flights being delayed.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated March 21, 2026.
Get a feel of what it's like to fly with Air France,Turkish Airlines, andIberia from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,547 reviews

Entertainment

7.0

Overall

7.4

Crew

8.1

Food

7.0

Comfort

7.3

Boarding

7.4

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Air France
7.4
Good
1,547 reviews
Air France
7.4
Good
1,547 reviews

Entertainment

7.0

Overall

7.4

Crew

8.1

Food

7.0

Comfort

7.3

Boarding

7.4

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Turkish Airlines
7.3
Good
4,266 reviews
Air France
7.4
Good
1,547 reviews

Entertainment

7.0

Overall

7.4

Crew

8.1

Food

7.0

Comfort

7.3

Boarding

7.4

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Iberia
7.0
Good
3,147 reviews
Air France
7.4
Good
1,547 reviews

Entertainment

7.0

Overall

7.4

Crew

8.1

Food

7.0

Comfort

7.3

Boarding

7.4

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Air Europa
6.9
Okay
597 reviews
Air France
7.4
Good
1,547 reviews

Entertainment

7.0

Overall

7.4

Crew

8.1

Food

7.0

Comfort

7.3

Boarding

7.4

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Avianca
6.5
Okay
2,503 reviews
Air France
7.4
Good
1,547 reviews

Entertainment

7.0

Overall

7.4

Crew

8.1

Food

7.0

Comfort

7.3

Boarding

7.4

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 25 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Spain?

    Turkish Airlines, KLM, and Air Europa can get you from Panama City to Spain in just under 20h 20m. Your travel time can differ by up to 14h 20m. Panama City and Spain are separated by a distance of 5006 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Turkish Airlines, which is currently one of the cheapest options available, starting at $434. Avianca flights start at $508 while deals on Air Europa start at $518 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Santander or Panama City Tocumen Intl - Malaga when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Air Europa (87%), Etihad Airways (87%) or China Eastern (87%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,444 for a flight from Panama City to Spain. The cheapest flight overall is $586 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $665.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in December is currently the most expensive (average of $703). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 8 airlines flying from Panama City to Spain

Discover the top 8 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$618Average$1,096FlexibilityNo cancel feeOn-time75%
AviancaCheapest$635Average$1,075FlexibilityNo cancel feeOn-time71%
IberiaCheapest$666Average$901FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$674Average$913FlexibilityNo cancel feeOn-time83%
Air FranceCheapest$685Average$837FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$760FlexibilityNo cancel feeOn-time77%
Copa AirlinesCheapest$722Average$1,269FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$841Average$956FlexibilityNo cancel feeOn-time69%

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