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$403+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
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Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This Avianca deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/272:55 amPTY - MAD
1 stop23h 55mAvianca
Sat 1/176:35 amMAD - PTY
1 stop13h 25mAvianca
Deal found 10/12$679
This FlightHub deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Fri 11/283:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 10/12$684
This Air Europa deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/39:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Fri 11/283:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 10/13$695
This CheapOair deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/89:45 pmPTY - MAD
1 stop33h 35mTurkish Airlines
Sun 11/2311:55 amMAD - PTY
1 stop37h 55mTurkish Airlines
Deal found 10/12$719
This SmartFares deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/129:45 pmPTY - MAD
1 stop33h 35mTurkish Airlines
Fri 11/145:55 pmMAD - PTY
1 stop31h 55mTurkish Airlines
Deal found 10/12$740
This CheapOair deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/89:45 pmPTY - MAD
1 stop36h 40mTurkish Airlines
Sat 11/156:20 amMAD - PTY
1 stop19h 30mTurkish Airlines
Deal found 10/12$741
This Air France deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/410:20 pmPTY - MAD
1 stop18h 45mAir France
Tue 11/258:05 pmMAD - PTY
1 stop30h 05mAir France
Deal found 10/13$742
This Air France deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1610:20 pmPTY - MAD
1 stop18h 45mAir France
Tue 11/258:05 pmMAD - PTY
1 stop30h 05mAir France
Deal found 10/13$746
This Air Europa deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/219:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Mon 1/193:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 10/12$748
This KLM deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:45 pmPTY - MAD
1 stop15h 20mMultiple Airlines
Mon 11/246:45 pmMAD - PTY
1 stop31h 25mMultiple Airlines
Deal found 10/13$753
This Air France deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:20 pmPTY - MAD
1 stop14h 50mAir France
Wed 12/316:00 amMAD - PTY
1 stop20h 10mAir France
Deal found 10/13$754
This KLM deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1610:20 pmPTY - VLC
1 stop13h 35mMultiple Airlines
Sun 11/238:50 pmVLC - PTY
1 stop25h 40mMultiple Airlines
Deal found 10/14$755

Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated October 14, 2025.

Round-trip from

$659
(KLM)

One-way from

$403
(Mytrip)

Popular in

December

Cheapest in

March

Average price

$793

Good round-trip deal

$714 or less

Good one-way deal

$624 or less
From Panama City Tocumen Intl to Spain
Search Deals
One-way flight from Panama City Tocumen Intl to Spain
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($32 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 2/4

10:05 pm-11:25 pm

1 stop19h 20m

Madrid Barajas

Wed 2/18

6:00 am-7:55 pm

1 stop19h 55m

$670

Panama CitySeville

PTY - SVQ

PTYSVQ

Panama City Tocumen Intl

Mon 2/2

10:05 pm-7:40 pm

1 stop15h 35m

Sevilla

Mon 2/9

6:45 pm-4:30 pm

1 stop27h 45m

$708

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 3/9

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Sun 3/22

5:55 pm-7:50 pm

1 stop31h 55m

$744

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Sun 2/8

6:45 pm-9:45 am

1 stop33h 00m

Malaga

Sun 2/15

8:20 pm-4:30 pm

1 stop26h 10m

$756

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 3/8

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

Wed 3/18

3:10 pm-7:45 pm

Nonstop10h 35m

$757

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 3/4

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Sun 3/22

2:25 pm-7:50 pm

1 stop35h 25m

$767

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 3/9

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Tue 3/17

5:55 pm-7:50 pm

1 stop31h 55m

$767

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Wed 3/18

9:45 pm-10:55 am

1 stop31h 10m

Valencia

Sun 3/22

11:55 am-7:50 pm

1 stop37h 55m

$774

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Wed 3/18

9:45 pm-11:40 am

1 stop31h 55m

Malaga

Sun 3/22

5:40 pm-7:50 pm

1 stop32h 10m

$776

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Tue 2/17

3:27 pm-4:10 pm

2 stops18h 43m

Valencia

Sun 3/22

6:00 am-8:10 pm

2 stops20h 10m

$780

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/13

Showing 1-10 of 53 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in September is currently the most expensive (average of $650). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 14, 2025.

It’s optimal to fly from Panama City to Spain in the evening. By choosing this option you can save up to 18% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated October 14, 2025.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Air Europa from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,475 reviews

Food

7.0

Overall

7.4

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Air France
7.4
Good
1,475 reviews
Air France
7.4
Good
1,475 reviews

Food

7.0

Overall

7.4

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Turkish Airlines
7.3
Good
4,007 reviews
Air France
7.4
Good
1,475 reviews

Food

7.0

Overall

7.4

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Air Europa
7.0
Good
568 reviews
Air France
7.4
Good
1,475 reviews

Food

7.0

Overall

7.4

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Iberia
7.0
Good
2,988 reviews
Air France
7.4
Good
1,475 reviews

Food

7.0

Overall

7.4

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Avianca
6.6
Okay
2,451 reviews
Air France
7.4
Good
1,475 reviews

Food

7.0

Overall

7.4

Comfort

7.4

Crew

8.2

Entertainment

7.0

Boarding

7.4

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 19 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Spain?

    KLM, Turkish Airlines, and Air Europa can get you from Panama City to Spain in just under 9h 35m. Your travel time can differ by up to 21h 05m. Panama City and Spain are separated by a distance of 5065 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Air Europa, which is currently one of the cheapest options available, starting at $521. KLM flights start at $541 while deals on Avianca start at $661 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Granadilla Tenerife-Sur when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Pascan (89%), Air Europa (88%) or Etihad Airways (88%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,209 for a flight from Panama City to Spain. The cheapest flight overall is $520 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $653.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in September is currently the most expensive (average of $650). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 8 airlines flying from Panama City to Spain

Discover the top 8 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$614Average$965FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$657Average$849FlexibilityNo cancel feeOn-time83%
KLMCheapest$664Average$946FlexibilityNo cancel feeOn-time75%
IberiaCheapest$679Average$841FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$697Average$819FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$793FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$832FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$728Average$1,190FlexibilityNo cancel feeOn-time70%

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