HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Spain

$508+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Spain with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Air France deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:20 pmPTY - MAD
1 stop28h 50mMultiple Airlines
Wed 1/216:00 amMAD - PTY
1 stop16h 30mMultiple Airlines
Deal found 11/11$731
This Turkish Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:45 pmPTY - MAD
1 stop40h 05mTurkish Airlines
Tue 12/25:55 pmMAD - PTY
1 stop31h 55mTurkish Airlines
Deal found 11/12$738
This Air Europa deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Fri 3/133:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/12$757
This Turkish Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/229:45 pmPTY - MAD
1 stop31h 05mTurkish Airlines
Mon 12/82:25 pmMAD - PTY
2 stops32h 40mTurkish Airlines
Deal found 11/11$764
This British Airways deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/226:20 pmPTY - MAD
Nonstop10h 05mIberia
Sat 2/1411:40 amMAD - PTY
Nonstop11h 05mIberia
Deal found 11/13$775
This FlightHub deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Wed 3/43:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/11$778
This KLM deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:45 pmPTY - BCN
1 stop35h 30mMultiple Airlines
Tue 12/26:05 pmBCN - PTY
1 stop32h 05mMultiple Airlines
Deal found 11/11$785
This Avianca deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:50 pmPTY - MAD
1 stop23h 30mAvianca
Fri 1/301:20 amMAD - PTY
1 stop21h 35mAvianca
Deal found 11/13$786
This Air Europa deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Fri 3/133:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/12$789
This Air France deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2510:20 pmPTY - MAD
1 stop28h 50mAir France
Tue 12/28:05 pmMAD - PTY
1 stop30h 05mAir France
Deal found 11/11$796
This KLM deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:45 pmPTY - MAD
1 stop18h 55mKLM
Wed 1/146:00 amMAD - PTY
1 stop19h 55mKLM
Deal found 11/12$801
This Turkish Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:45 pmPTY - BCN
1 stop23h 05mTurkish Airlines
Fri 1/306:25 pmBCN - PTY
2 stops28h 40mTurkish Airlines
Deal found 11/11$802

Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated November 13, 2025.

Round-trip from

$680
(KLM)

One-way from

$508
(Booking.com)

Popular in

January

Cheapest in

March

Average price

$818

Good round-trip deal

$810 or less

Good one-way deal

$635 or less
From Panama City Tocumen Intl to Spain
Search Deals
One-way flight from Panama City Tocumen Intl to Spain
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($31 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/2

10:05 pm-11:25 pm

1 stop19h 20m

Madrid Barajas

Mon 2/16

11:00 am-7:55 pm

1 stop14h 55m

$689

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Fri 2/6

6:45 pm-10:55 am

1 stop34h 10m

Valencia

Fri 3/6

6:10 pm-7:50 pm

1 stop31h 40m

$725

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Wed 4/1

10:15 pm-10:55 am

1 stop29h 40m

Malaga

Mon 4/6

12:25 pm-6:30 pm

2 stops37h 05m

$732

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Sun 2/8

6:45 pm-11:40 am

1 stop34h 55m

Malaga

Sun 2/15

5:40 pm-7:50 pm

1 stop32h 10m

$732

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Wed 3/18

9:45 pm-5:10 pm

1 stop37h 25m

Valencia

Sun 3/22

6:10 pm-7:50 pm

1 stop31h 40m

$769

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Wed 3/18

9:45 pm-11:40 am

1 stop31h 55m

Malaga

Sun 3/22

12:40 pm-7:50 pm

1 stop37h 10m

$785

Panama CitySeville

PTY - SVQ

PTYSVQ

Panama City Tocumen Intl

Tue 3/31

6:50 pm-7:55 pm

1 stop18h 05m

Sevilla

Tue 4/14

5:15 pm-4:50 pm

2 stops30h 35m

$787

Panama CitySeville

PTY - SVQ

PTYSVQ

Panama City Tocumen Intl

Sun 3/22

6:45 pm-4:45 pm

1 stop40h 00m

Sevilla

Thu 3/26

5:45 pm-5:05 pm

2 stops29h 20m

$810

Panama CitySeville

PTY - SVQ

PTYSVQ

Panama City Tocumen Intl

Thu 3/5

6:45 pm-10:50 am

1 stop34h 05m

Sevilla

Thu 3/19

5:45 pm-5:05 pm

2 stops29h 20m

$810

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Wed 4/1

6:50 pm-7:15 pm

1 stop17h 25m

Malaga

Mon 4/6

5:20 pm-4:50 pm

1 stop30h 30m

$837

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in September is currently the most expensive (average of $650). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

It’s optimal to fly from Panama City to Spain in the evening. By choosing this option you can save up to 18% on the cost of your flight, compared to a flight at noon.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 13, 2025.

The most flights from PTY to ES0 are scheduled on a Monday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated November 13, 2025.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Air Europa from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,486 reviews

Overall

7.4

Crew

8.2

Comfort

7.4

Entertainment

7.0

Boarding

7.4

Food

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Air France
7.4
Good
1,486 reviews
Air France
7.4
Good
1,486 reviews

Overall

7.4

Crew

8.2

Comfort

7.4

Entertainment

7.0

Boarding

7.4

Food

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Turkish Airlines
7.3
Good
4,044 reviews
Air France
7.4
Good
1,486 reviews

Overall

7.4

Crew

8.2

Comfort

7.4

Entertainment

7.0

Boarding

7.4

Food

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Air Europa
7.0
Good
569 reviews
Air France
7.4
Good
1,486 reviews

Overall

7.4

Crew

8.2

Comfort

7.4

Entertainment

7.0

Boarding

7.4

Food

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Iberia
7.0
Good
3,010 reviews
Air France
7.4
Good
1,486 reviews

Overall

7.4

Crew

8.2

Comfort

7.4

Entertainment

7.0

Boarding

7.4

Food

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.
Avianca
6.6
Okay
2,475 reviews
Air France
7.4
Good
1,486 reviews

Overall

7.4

Crew

8.2

Comfort

7.4

Entertainment

7.0

Boarding

7.4

Food

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

SGN - CDG

Staff attentive, would have liked a covering on the seats for sleeping (as Vietnam airways did - and others) ‘duvet’ cover very light- needed but heavier. Food not great, scallop did not smell right, chicken over cooked.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 19 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Spain?

    KLM, Turkish Airlines, and United Airlines can get you from Panama City to Spain in just under 19h 20m. Your travel time can differ by up to 14h 50m. Panama City and Spain are separated by a distance of 5065 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with KLM, which is currently one of the cheapest options available, starting at $511. Air Europa flights start at $521 while deals on Turkish Airlines start at $667 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Valencia when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Air Europa (89%), Etihad Airways (89%) or China Eastern (89%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $858 for a flight from Panama City to Spain. The cheapest flight overall is $526 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $667.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in September is currently the most expensive (average of $650). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 8 airlines flying from Panama City to Spain

Discover the top 8 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$614Average$960FlexibilityNo cancel feeOn-time71%
KLMCheapest$654Average$938FlexibilityNo cancel feeOn-time75%
Air EuropaCheapest$661Average$850FlexibilityNo cancel feeOn-time83%
IberiaCheapest$677Average$852FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$697Average$823FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$781FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$854FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$728Average$1,232FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.