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$446+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Feb 6 — Feb 131
Fri 2/6
Fri 2/13
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated January 7, 2026.

Round-trip from

$664
(FlightHub)

One-way from

$446
(Kiwi.com)

Popular in

January

Cheapest in

October

Average price

$954

Good round-trip deal

$789 or less

Good one-way deal

$636 or less
From Panama City Tocumen Intl to Spain
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One-way flight from Panama City Tocumen Intl to Spain
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Highest demand for flights based on searches. 5% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
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Find flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.

This FlightHub deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:25 pmPTY - BCN
1 stop13h 10mAir Europa
Sat 5/911:50 amBCN - PTY
1 stop13h 50mAir Europa
Deal found 1/6$664
This KLM deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:50 pmPTY - BCN
1 stop30h 55mKLM
Sat 5/305:20 pmBCN - PTY
1 stop30h 30mKLM
Deal found 1/4$681
This KLM deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:50 pmPTY - BCN
1 stop20h 55mKLM
Thu 5/286:20 amBCN - PTY
1 stop17h 30mKLM
Deal found 1/6$698
This KLM deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:50 pmPTY - MAD
1 stop21h 35mKLM
Wed 6/36:00 amMAD - PTY
1 stop17h 50mKLM
Deal found 1/6$705
This FlightHub deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:25 pmPTY - BCN
1 stop29h 30mAir Europa
Wed 4/2211:50 amBCN - PTY
1 stop13h 50mAir Europa
Deal found 1/5$705
This Booking.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:20 pmPTY - BCN
1 stop18h 00mTurkish Airlines
Sat 5/167:35 amBCN - PTY
1 stop19h 50mTurkish Airlines
Deal found 1/4$706
This Air Europa deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:25 pmPTY - VGO
1 stop16h 55mAir Europa
Thu 4/2312:35 pmVGO - PTY
1 stop13h 05mAir Europa
Deal found 1/6$707
This FlightHub deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:25 pmPTY - BCN
1 stop13h 10mAir Europa
Fri 10/98:30 pmBCN - PTY
1 stop29h 10mAir Europa
Deal found 1/5$708
This KLM deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/210:05 pmPTY - MAD
1 stop30h 10mKLM
Wed 2/184:50 pmMAD - PTY
1 stop29h 40mKLM
Deal found 1/6$709
This Air France deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:20 pmPTY - MAD
1 stop14h 55mMultiple Airlines
Sat 5/166:00 amMAD - PTY
1 stop17h 50mMultiple Airlines
Deal found 1/6$711
This FlightHub deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/239:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Mon 3/233:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 1/4$713
This KLM deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/210:05 pmPTY - MAD
1 stop30h 10mKLM
Fri 3/64:50 pmMAD - PTY
1 stop29h 40mKLM
Deal found 1/6$714

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityVigo

PTY - VGO

PTYVGO

Panama City Tocumen Intl

Sun 4/19

8:25 pm-8:20 pm

1 stop16h 55m

Vigo

Thu 4/23

8:40 am-6:40 pm

1 stop17h 00m

$707

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 4/30

2:20 pm-12:15 pm

1 stop14h 55m

Madrid Barajas

Tue 5/19

10:05 am-7:45 pm

1 stop16h 40m

$711

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Fri 4/17

8:25 pm-8:55 am

1 stop29h 30m

Barcelona-El Prat

Sat 5/2

11:50 am-6:40 pm

1 stop13h 50m

$727

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Mon 2/9

9:45 pm-5:05 pm

1 stop37h 20m

Barcelona-El Prat

Sun 2/15

12:10 pm-5:05 pm

2 stops34h 55m

$734

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 2/6

6:45 pm-1:20 pm

1 stop36h 35m

Madrid Barajas

Sun 3/8

2:25 pm-7:50 pm

1 stop35h 25m

$738

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 2/18

9:45 pm-1:20 pm

1 stop33h 35m

Madrid Barajas

Sat 3/7

6:20 am-7:50 pm

1 stop19h 30m

$748

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Tue 2/10

6:45 pm-1:25 pm

1 stop36h 40m

Barcelona-El Prat

Sat 2/28

2:25 pm-5:05 pm

2 stops32h 40m

$750

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Mon 2/9

10:05 pm-11:05 pm

1 stop19h 00m

Barcelona-El Prat

Wed 2/18

6:00 am-8:10 pm

1 stop20h 10m

$754

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Mon 1/26

10:05 pm-9:05 am

1 stop29h 00m

Valencia

Tue 2/24

4:55 pm-7:55 pm

1 stop33h 00m

$755

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Sun 2/8

6:45 pm-4:40 pm

1 stop39h 55m

Malaga

Sun 2/15

12:40 pm-7:50 pm

1 stop37h 10m

$755

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/5

Showing 1-10 of 54 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in December is currently the most expensive (average of $699). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 7, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 7, 2026.

The most flights from PTY to ES0 are scheduled on a Monday (10 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (4 on average).

How often are flights from Panama City to Spain delayed?

About 14% of weekly flights between Panama City and Spain have experienced delays in the past year, with the average delay time being 133 minutes.

What is the most punctual flight time for Panama City to Spain flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Monday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama City to Spain flights?

Over the last year, Pascan have had the lowest number of delays on this route, with just 6% of flights being delayed.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated January 7, 2026.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Air Europa from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,519 reviews

Food

7.0

Crew

8.1

Comfort

7.4

Boarding

7.4

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Jayesh,Jan 2026

EWR - CDG

More choice on Food Coffee portion was small, the cups could be bigger. Dessert could have more options.
Air France
7.4
Good
1,519 reviews
Air France
7.4
Good
1,519 reviews

Food

7.0

Crew

8.1

Comfort

7.4

Boarding

7.4

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Jayesh,Jan 2026

EWR - CDG

More choice on Food Coffee portion was small, the cups could be bigger. Dessert could have more options.
Turkish Airlines
7.3
Good
4,152 reviews
Air France
7.4
Good
1,519 reviews

Food

7.0

Crew

8.1

Comfort

7.4

Boarding

7.4

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Jayesh,Jan 2026

EWR - CDG

More choice on Food Coffee portion was small, the cups could be bigger. Dessert could have more options.
Air Europa
7.0
Good
580 reviews
Air France
7.4
Good
1,519 reviews

Food

7.0

Crew

8.1

Comfort

7.4

Boarding

7.4

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Jayesh,Jan 2026

EWR - CDG

More choice on Food Coffee portion was small, the cups could be bigger. Dessert could have more options.
Iberia
7.0
Good
3,074 reviews
Air France
7.4
Good
1,519 reviews

Food

7.0

Crew

8.1

Comfort

7.4

Boarding

7.4

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Jayesh,Jan 2026

EWR - CDG

More choice on Food Coffee portion was small, the cups could be bigger. Dessert could have more options.
Avianca
6.6
Okay
2,498 reviews
Air France
7.4
Good
1,519 reviews

Food

7.0

Crew

8.1

Comfort

7.4

Boarding

7.4

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Jayesh,Jan 2026

EWR - CDG

More choice on Food Coffee portion was small, the cups could be bigger. Dessert could have more options.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 21 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Spain?

    Air Europa, Air France, and Turkish Airlines can get you from Panama City to Spain in just under 14h 55m. Your travel time can differ by up to 22h 25m. Panama City and Spain are separated by a distance of 5065 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Air Europa, which is currently one of the cheapest options available, starting at $419. Turkish Airlines flights start at $434 while deals on Avianca start at $535 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Malaga when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Qatar Airways (81%), Iberia (81%) or EL AL (81%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,629 for a flight from Panama City to Spain. The cheapest flight overall is $615 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $641.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in December is currently the most expensive (average of $699). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Panama City to Spain

Discover the top 7 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$614Average$958FlexibilityNo cancel feeOn-time71%
KLMCheapest$654Average$935FlexibilityNo cancel feeOn-time75%
Air EuropaCheapest$665Average$885FlexibilityNo cancel feeOn-time83%
IberiaCheapest$677Average$905FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$695Average$821FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$774FlexibilityNo cancel feeOn-time77%
Copa AirlinesCheapest$728Average$1,280FlexibilityNo cancel feeOn-time70%

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