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$489+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Avianca deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/25:50 pm
PTY
-
MAD
1 stop13h 35m
Avianca
Mon 2/166:35 am
MAD
-
PTY
1 stop16h 20m
Avianca
Deal found 1/20$658
This KLM deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:50 pm
PTY
-
MAD
1 stop31h 40m
Multiple Airlines
Wed 6/1010:05 am
MAD
-
PTY
2 stops17h 15m
Multiple Airlines
Deal found 1/20$659
This FlightHub deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Tue 6/93:05 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 1/20$660
This KLM deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2110:05 pm
PTY
-
MAD
1 stop30h 10m
KLM
Mon 2/27:05 am
MAD
-
PTY
1 stop18h 50m
KLM
Deal found 1/20$662
This Trip.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:25 pm
PTY
-
AGP
1 stop12h 50m
Air Europa
Sun 10/1812:35 pm
AGP
-
PTY
1 stop13h 05m
Air Europa
Deal found 1/20$664
This Air Europa deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:25 pm
PTY
-
VGO
1 stop16h 55m
Air Europa
Thu 4/2312:35 pm
VGO
-
PTY
1 stop13h 05m
Air Europa
Deal found 1/19$664
This FlightHub deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:25 pm
PTY
-
BCN
1 stop13h 10m
Air Europa
Thu 4/2311:50 am
BCN
-
PTY
1 stop13h 50m
Air Europa
Deal found 1/20$664
This Air France deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:30 pm
PTY
-
MAD
1 stop17h 45m
Air France
Wed 6/108:15 pm
MAD
-
PTY
1 stop30h 30m
Air France
Deal found 1/20$665
This Booking.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/19:30 pm
PTY
-
MAD
Nonstop9h 50m
Iberia
Fri 5/83:55 pm
MAD
-
PTY
Nonstop11h 05m
Iberia
Deal found 1/19$668
This Avianca deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/19:45 am
PTY
-
MAD
1 stop12h 50m
Avianca
Mon 3/91:20 am
MAD
-
PTY
1 stop13h 30m
Avianca
Deal found 1/20$669
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/19:30 pm
PTY
-
MAD
Nonstop9h 50m
Iberia
Sun 5/173:55 pm
MAD
-
PTY
Nonstop11h 05m
Iberia
Deal found 1/20$670
This British Airways deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/19:30 pm
PTY
-
MAD
Nonstop9h 50m
Iberia
Fri 5/153:55 pm
MAD
-
PTY
Nonstop11h 05m
Iberia
Deal found 1/21$671

Find flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated January 21, 2026.

Round-trip from

$658
(Avianca)

One-way from

$489
(Kiwi.com)

Popular in

January

Cheapest in

October

Average price

$999

Good round-trip deal

$776 or less

Good one-way deal

$657 or less
From Panama City Tocumen Intl to Spain
Search Deals
One-way flight from Panama City Tocumen Intl to Spain
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($61 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityVigo

PTY - VGO

PTYVGO

Panama City Tocumen Intl

Mon 4/20

8:25 pm-8:20 pm

1 stop16h 55m

Vigo

Thu 4/23

12:35 pm-6:40 pm

1 stop13h 05m

$664

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 3/31

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Tue 4/14

3:05 pm-6:40 pm

Nonstop10h 35m

$676

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Wed 3/18

6:20 pm-12:05 am

1 stop23h 45m

Valencia

Tue 4/14

5:40 pm-8:00 pm

1 stop33h 20m

$685

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Wed 5/27

6:50 pm-10:45 pm

1 stop20h 55m

Barcelona-El Prat

Thu 6/18

6:10 am-7:45 pm

1 stop20h 35m

$698

Panama CityBilbao

PTY - BIO

PTYBIO

Panama City Tocumen Intl

Mon 3/16

9:45 pm-4:10 pm

1 stop36h 25m

Bilbao

Tue 3/24

12:00 pm-7:50 pm

1 stop37h 50m

$700

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Sat 6/6

6:50 pm-10:45 pm

1 stop20h 55m

Barcelona-El Prat

Sun 6/14

6:20 am-4:50 pm

1 stop17h 30m

$702

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 1/29

6:45 pm-10:15 am

1 stop33h 30m

Madrid Barajas

Wed 4/15

4:40 pm-7:45 pm

1 stop34h 05m

$707

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Tue 6/9

6:50 pm-8:25 am

1 stop30h 35m

Valencia

Mon 6/15

6:40 am-7:45 pm

1 stop20h 05m

$715

Panama CityBilbao

PTY - BIO

PTYBIO

Panama City Tocumen Intl

Mon 4/27

10:20 pm-5:20 pm

1 stop36h 00m

Bilbao

Mon 5/4

12:10 pm-6:25 pm

2 stops37h 15m

$716

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Sat 2/14

9:45 pm-4:40 pm

1 stop36h 55m

Malaga

Tue 2/24

12:40 pm-5:05 pm

2 stops34h 25m

$718

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 57 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in December is currently the most expensive (average of $701). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

How often are flights from Panama City to Spain delayed?

About 12% of weekly flights between Panama City and Spain have experienced delays in the past year, with the average delay time being 135 minutes.

What is the most punctual flight time for Panama City to Spain flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Sunday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama City to Spain flights?

Over the last year, Pascan have had the lowest number of delays on this route, with just 6% of flights being delayed.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated January 21, 2026.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Iberia from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,523 reviews

Crew

8.1

Overall

7.4

Boarding

7.4

Comfort

7.3

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Air France
7.4
Good
1,523 reviews
Air France
7.4
Good
1,523 reviews

Crew

8.1

Overall

7.4

Boarding

7.4

Comfort

7.3

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Turkish Airlines
7.3
Good
4,200 reviews
Air France
7.4
Good
1,523 reviews

Crew

8.1

Overall

7.4

Boarding

7.4

Comfort

7.3

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Iberia
7.0
Good
3,094 reviews
Air France
7.4
Good
1,523 reviews

Crew

8.1

Overall

7.4

Boarding

7.4

Comfort

7.3

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Air Europa
6.9
Okay
588 reviews
Air France
7.4
Good
1,523 reviews

Crew

8.1

Overall

7.4

Boarding

7.4

Comfort

7.3

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Avianca
6.6
Okay
2,496 reviews
Air France
7.4
Good
1,523 reviews

Crew

8.1

Overall

7.4

Boarding

7.4

Comfort

7.3

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 24 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Spain?

    Air Europa, Iberia, and Turkish Airlines can get you from Panama City to Spain in just under 16h 55m. Your travel time can differ by up to 19h 30m. Panama City and Spain are separated by a distance of 4812 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Air Europa, which is currently one of the cheapest options available, starting at $419. Turkish Airlines flights start at $434 while deals on Avianca start at $535 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Bilbao or Panama City Tocumen Intl - Barcelona-El Prat when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Qatar Airways (84%), Iberia (84%) or EL AL (84%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $889 for a flight from Panama City to Spain. The cheapest flight overall is $615 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $628.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in December is currently the most expensive (average of $701). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Spain

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Top 7 airlines flying from Panama City to Spain

Discover the top 7 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$597Average$1,028FlexibilityNo cancel feeOn-time71%
KLMCheapest$654Average$1,079FlexibilityNo cancel feeOn-time75%
Air EuropaCheapest$666Average$885FlexibilityNo cancel feeOn-time83%
IberiaCheapest$674Average$899FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$695Average$841FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$773FlexibilityNo cancel feeOn-time77%
Copa AirlinesCheapest$722Average$1,269FlexibilityNo cancel feeOn-time70%

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