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$490+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated September 11, 2025.

Round-trip from

$678
(FlightHub)

One-way from

$490
(Kiwi.com)

Popular in

July

Cheapest in

March

Average price

$845

Good round-trip deal

$773 or less

Good one-way deal

$632 or less
From Panama City Tocumen Intl to Spain
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One-way flight from Panama City Tocumen Intl to Spain
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Highest demand for flights based on searches. 5% potential increase in price ($47 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
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Find flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This FlightHub deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/169:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Sat 11/223:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/10$678
This Booking.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/19:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Sun 12/143:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/11$681
This FlightHub deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Sat 12/63:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/11$683
This Air Europa deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/148:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Fri 10/313:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/11$688
This Air Europa deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Sun 11/233:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/10$689
This Air Europa deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/88:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Mon 10/203:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/10$694
This Trip.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Fri 11/73:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/11$696
This Turkish Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/89:55 pmPTY - AGP
1 stop30h 05mTurkish Airlines
Sat 10/186:00 pmAGP - PTY
1 stop33h 00mTurkish Airlines
Deal found 9/10$707
This Booking.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/78:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Tue 10/143:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 9/10$708
This CheapOair deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/19:55 pmPTY - BCN
1 stop36h 10mTurkish Airlines
Wed 10/87:50 amBCN - PTY
1 stop19h 10mTurkish Airlines
Deal found 9/10$715
This Air Europa deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/138:25 pmPTY - BCN
1 stop13h 10mAir Europa
Sat 10/2511:50 amBCN - PTY
1 stop13h 50mAir Europa
Deal found 9/11$716
This KLM deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:50 pmPTY - MAD
1 stop17h 40mKLM
Thu 11/66:00 amMAD - PTY
1 stop16h 30mKLM
Deal found 9/11$717

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Wed 10/8

9:55 pm-11:00 am

1 stop30h 05m

Malaga

Sat 10/18

6:00 pm-8:00 pm

1 stop33h 00m

$707

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Sun 11/2

9:30 pm-8:05 am

1 stop28h 35m

Valencia

Tue 12/2

12:25 pm-7:45 pm

1 stop13h 20m

$721

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Sun 10/19

8:25 pm-4:35 pm

1 stop13h 10m

Barcelona-El Prat

Fri 10/24

8:30 pm-6:40 pm

1 stop29h 10m

$727

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Mon 11/10

9:30 pm-8:55 am

1 stop29h 25m

Barcelona-El Prat

Thu 11/13

8:30 pm-7:45 pm

1 stop29h 15m

$735

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Fri 2/6

9:30 pm-4:15 pm

1 stop12h 45m

Valencia

Fri 3/6

12:25 pm-7:45 pm

1 stop13h 20m

$743

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Wed 10/15

9:55 pm-5:00 pm

1 stop36h 05m

Malaga

Sun 11/9

12:40 pm-7:50 pm

1 stop37h 10m

$749

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 11/1

9:45 pm-10:35 am

1 stop30h 50m

Madrid Barajas

Thu 11/13

6:20 am-5:05 pm

2 stops40h 45m

$762

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 10/19

9:55 pm-1:35 pm

1 stop32h 40m

Madrid Barajas

Sun 10/26

11:55 am-7:50 pm

1 stop37h 55m

$763

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 11/1

9:45 pm-4:25 pm

1 stop36h 40m

Madrid Barajas

Sat 11/15

6:20 am-7:50 pm

1 stop19h 30m

$763

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Sun 2/1

6:45 pm-9:15 am

1 stop32h 30m

Valencia

Sun 2/8

8:50 pm-4:30 pm

1 stop25h 40m

$780

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 60 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 11, 2025.

The most flights from PTY to ES0 are scheduled on a Monday (5 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (5 on average).

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with KLM, Air France, and Air Europa from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,385 reviews

Entertainment

7.2

Food

7.3

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Mark,Sep 2025

AMS - BHX

Crew and snacks were good, boarding wasn't great as busses were used rather than boarding tunnels. Also endured a one hour delay.
KLM
7.8
Good
1,385 reviews
KLM
7.8
Good
1,385 reviews

Entertainment

7.2

Food

7.3

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Mark,Sep 2025

AMS - BHX

Crew and snacks were good, boarding wasn't great as busses were used rather than boarding tunnels. Also endured a one hour delay.
Air France
7.4
Good
1,469 reviews
KLM
7.8
Good
1,385 reviews

Entertainment

7.2

Food

7.3

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Mark,Sep 2025

AMS - BHX

Crew and snacks were good, boarding wasn't great as busses were used rather than boarding tunnels. Also endured a one hour delay.
Air Europa
7.0
Good
556 reviews
KLM
7.8
Good
1,385 reviews

Entertainment

7.2

Food

7.3

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Mark,Sep 2025

AMS - BHX

Crew and snacks were good, boarding wasn't great as busses were used rather than boarding tunnels. Also endured a one hour delay.
Iberia
7.0
Good
2,929 reviews
KLM
7.8
Good
1,385 reviews

Entertainment

7.2

Food

7.3

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Mark,Sep 2025

AMS - BHX

Crew and snacks were good, boarding wasn't great as busses were used rather than boarding tunnels. Also endured a one hour delay.
Avianca
6.7
Okay
2,436 reviews
KLM
7.8
Good
1,385 reviews

Entertainment

7.2

Food

7.3

Overall

7.8

Comfort

7.7

Crew

8.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Mark,Sep 2025

AMS - BHX

Crew and snacks were good, boarding wasn't great as busses were used rather than boarding tunnels. Also endured a one hour delay.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 15 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Spain?

    Turkish Airlines, Air Europa, and KLM can get you from Panama City to Spain in just under 28h 35m. Your travel time can differ by up to 3h 55m. Panama City and Spain are separated by a distance of 5227 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with KLM, which is currently one of the cheapest options available, starting at $510. Air Europa flights start at $530 while deals on Turkish Airlines start at $668 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Valencia when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Qatar Airways (94%), Iberia (94%) or EL AL (94%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $787 for a flight from Panama City to Spain. The cheapest flight overall is $558 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $609.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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Top 8 airlines flying from Panama City to Spain

Discover the top 8 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$543Average$956FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$665Average$846FlexibilityNo cancel feeOn-time83%
IberiaCheapest$680Average$953FlexibilityNo cancel feeOn-time77%
KLMCheapest$681Average$880FlexibilityNo cancel feeOn-time75%
Air FranceCheapest$695Average$851FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$790FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$832FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$826Average$1,180FlexibilityNo cancel feeOn-time70%

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