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$450+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
May 5 — May 121
Mon 5/5
Mon 5/12
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated April 30, 2025.

Round-trip from

$718
(Turkish Airlines)

One-way from

$450
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$808

Good round-trip deal

$802 or less

Good one-way deal

$596 or less
From Panama City Tocumen Intl to Spain
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One-way flight from Panama City Tocumen Intl to Spain
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Highest demand for flights based on searches. 4% potential increase in price ($38 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
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Find flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

This KLM deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/236:50 pmPTY - MAD
1 stop31h 45mKLM
Wed 9/105:10 pmMAD - PTY
1 stop30h 40mKLM
Deal found 4/28$698
This Air France deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/277:55 pmPTY - MAD
1 stop30h 15mAir France
Mon 6/96:00 amMAD - PTY
1 stop18h 45mAir France
Deal found 4/28$699
This Air France deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/18:00 amPTY - MAD
1 stop18h 35mMultiple Airlines
Mon 6/168:25 pmMAD - PTY
1 stop27h 25mMultiple Airlines
Deal found 4/28$713
This Turkish Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/169:55 pmPTY - MAD
1 stop29h 30mTurkish Airlines
Sat 5/242:45 pmMAD - PTY
1 stop36h 15mTurkish Airlines
Deal found 4/28$718
This Gotogate deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:55 pmPTY - MAD
1 stop18h 40mAvianca
Wed 11/54:20 pmMAD - PTY
1 stop14h 00mAvianca
Deal found 4/29$723
This SmartFares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/48:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Sat 10/113:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 4/28$744
This Iberia deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/245:35 pmPTY - MAD
Nonstop9h 50mIberia
Mon 6/912:00 pmMAD - PTY
Nonstop11h 05mIberia
Deal found 4/29$756
This Turkish Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/179:55 pmPTY - BCN
1 stop18h 15mTurkish Airlines
Tue 9/3012:00 pmBCN - PTY
1 stop39h 00mTurkish Airlines
Deal found 4/29$757
This Gotogate deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/278:25 pmPTY - BCN
1 stop13h 10mAir Europa
Tue 6/311:50 amBCN - PTY
1 stop13h 50mAir Europa
Deal found 4/29$761
This KLM deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/116:50 pmPTY - BCN
1 stop14h 35mMultiple Airlines
Tue 6/249:55 amBCN - PTY
1 stop14h 50mMultiple Airlines
Deal found 4/29$825
This KLM deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/186:50 pmPTY - BCN
1 stop30h 50mKLM
Sat 5/317:40 pmBCN - PTY
1 stop28h 10mKLM
Deal found 4/29$831
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/283:30 pmPTY - BCN
2 stops34h 30mUnited Airlines
Mon 7/1411:15 amBCN - PTY
2 stops33h 35mUnited Airlines
Deal found 4/29$841

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 7/23

6:50 pm-9:35 am

1 stop31h 45m

Madrid Barajas

Wed 9/10

5:10 pm-4:50 pm

1 stop30h 40m

$698

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 5/27

7:55 pm-9:10 am

1 stop30h 15m

Madrid Barajas

Mon 6/9

6:00 am-5:45 pm

1 stop18h 45m

$699

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 6/1

8:00 am-9:35 am

1 stop18h 35m

Madrid Barajas

Mon 6/16

8:25 pm-4:50 pm

1 stop27h 25m

$713

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/16

9:55 pm-10:25 am

1 stop29h 30m

Madrid Barajas

Sat 5/24

2:45 pm-8:00 pm

1 stop36h 15m

$718

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 10/22

3:20 am-11:30 pm

1 stop37h 10m

Madrid Barajas

Wed 11/12

10:55 am-9:00 pm

1 stop16h 05m

$724

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 10/4

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Sat 10/18

3:05 pm-6:40 pm

Nonstop10h 35m

$744

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/30

5:35 pm-10:25 am

Nonstop9h 50m

Madrid Barajas

Sun 6/8

12:00 pm-4:05 pm

Nonstop11h 05m

$756

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Wed 9/17

9:55 pm-11:10 pm

1 stop18h 15m

Barcelona-El Prat

Tue 9/30

12:00 pm-8:00 pm

1 stop39h 00m

$757

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Tue 5/27

8:25 pm-4:35 pm

1 stop13h 10m

Barcelona-El Prat

Tue 6/3

11:50 am-6:40 pm

1 stop13h 50m

$761

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Wed 6/11

6:50 pm-4:25 pm

1 stop14h 35m

Barcelona-El Prat

Tue 6/24

9:55 am-5:45 pm

1 stop14h 50m

$825

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 52 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,086). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

Rainfall in Spain by month

Plan your trip to Spain by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Spain ranges from 0.8 - 3.6 inches per month. October is typically the wettest month, when rainfall can reach 3.6 in. July is typically the driest time to visit Spain when rainfall is around 0.8 in.

Temperature in Spain by month

Plan your trip to Spain by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Spain, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated April 30, 2025.
See what other customers who have flown with Delta, KLM and Air France from Panama City to Spain have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
Delta
8.0
Very good
7,929 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
KLM
7.8
Good
1,334 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
Air France
7.4
Good
1,446 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!
Turkish Airlines
7.3
Good
3,788 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Aug 2023

ATL - BCN

Crew was great . NO WIFI FOR AN 8 HR FLIGHT !!!! WASNT NOTIFIED THIS SERIES OF AIR BUS HAS NO WIFI!!! COULDN'T DO ANY WORK. SPENT 150,000 POINTS TO UPGRADE TO DELTA ONE ONLY TO BE STUCK WITH NO WIFI. WAS ONLY OFFERED 5K POINTS!!!!!

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 17 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Turkish Airlines, which is currently one of the cheapest options available, starting at $450. Air Europa flights start at $527 while deals on Avianca start at $538 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Santiago de Compostela when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Air Europa (81%), Etihad Airways (81%) or China Eastern (81%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,712 for a flight from Panama City to Spain. The cheapest flight overall is $466 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $698.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,086). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Panama City to Spain

Discover the top 7 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$543Average$853FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$592Average$810FlexibilityNo cancel feeOn-time83%
IberiaCheapest$633Average$949FlexibilityNo cancel feeOn-time77%
KLMCheapest$670Average$873FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$678Average$813FlexibilityNo cancel feeOn-time69%
Air FranceCheapest$681Average$806FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$736Average$828FlexibilityNo cancel feeOn-time77%

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