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$470+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This KLM deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 pmPTY - MAD
1 stop36h 55mMultiple Airlines
Wed 1/216:00 amMAD - PTY
1 stop20h 10mMultiple Airlines
Deal found 12/10$731
This KLM deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 pmPTY - MAD
1 stop36h 55mMultiple Airlines
Mon 1/196:45 pmMAD - PTY
1 stop31h 25mMultiple Airlines
Deal found 12/11$733
This KLM deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:45 pmPTY - MAD
1 stop36h 55mMultiple Airlines
Tue 2/106:00 amMAD - PTY
1 stop20h 10mMultiple Airlines
Deal found 12/11$747
This KLM deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:45 pmPTY - MAD
1 stop18h 55mMultiple Airlines
Tue 1/206:00 amMAD - PTY
1 stop20h 10mMultiple Airlines
Deal found 12/11$752
This KLM deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:45 pmPTY - MAD
1 stop33h 30mMultiple Airlines
Mon 1/196:45 pmMAD - PTY
1 stop31h 25mMultiple Airlines
Deal found 12/11$753
This Air Europa deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Mon 2/23:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 12/10$757
This Air Europa deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Wed 2/43:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 12/10$789
This KLM deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 pmPTY - MAD
1 stop36h 55mKLM
Wed 3/48:30 pmMAD - PTY
1 stop26h 00mKLM
Deal found 12/10$815
This Air Europa deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Wed 1/213:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 12/11$821
This KLM deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:45 pmPTY - MAD
1 stop33h 30mKLM
Wed 2/47:05 amMAD - PTY
1 stop15h 25mKLM
Deal found 12/10$829
This KLM deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:40 pmPTY - VLC
2 stops17h 15mMultiple Airlines
Fri 1/236:00 amVLC - PTY
2 stops20h 10mMultiple Airlines
Deal found 12/11$860
This KLM deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:45 pmPTY - BCN
1 stop22h 20mMultiple Airlines
Thu 1/158:20 pmBCN - PTY
1 stop29h 50mMultiple Airlines
Deal found 12/11$895

Find flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated December 12, 2025.

Round-trip from

$713
(Booking.com)

One-way from

$470
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$919

Good round-trip deal

$811 or less

Good one-way deal

$629 or less
From Panama City Tocumen Intl to Spain
Search Deals
One-way flight from Panama City Tocumen Intl to Spain
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($46 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 2/4

10:05 pm-10:15 am

1 stop30h 10m

Madrid Barajas

Wed 2/18

6:00 am-8:10 pm

1 stop20h 10m

$724

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 2/15

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

Wed 3/4

3:10 pm-7:45 pm

Nonstop10h 35m

$725

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/2

6:45 pm-11:25 pm

1 stop22h 40m

Madrid Barajas

Mon 2/16

6:00 am-8:10 pm

1 stop20h 10m

$739

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Mon 5/4

8:25 pm-8:20 pm

1 stop16h 55m

Malaga

Thu 5/7

12:35 pm-6:40 pm

1 stop13h 05m

$743

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 2/10

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

Wed 3/4

3:10 pm-7:45 pm

Nonstop10h 35m

$757

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/9

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

Sat 3/7

3:10 pm-7:45 pm

Nonstop10h 35m

$757

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/9

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

Fri 3/6

3:10 pm-7:45 pm

Nonstop10h 35m

$757

Panama CityIbiza

PTY - IBZ

PTYIBZ

Panama City Tocumen Intl

Mon 5/18

8:25 pm-2:10 pm

1 stop34h 45m

Ibiza

Fri 5/22

3:00 pm-6:40 pm

1 stop34h 40m

$758

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Sun 2/8

6:45 pm-11:05 pm

1 stop22h 20m

Barcelona-El Prat

Sun 2/22

7:55 pm-7:55 pm

1 stop30h 00m

$763

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/22

6:50 pm-11:25 pm

1 stop21h 35m

Madrid Barajas

Mon 6/1

6:00 am-4:50 pm

1 stop17h 50m

$772

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 56 results
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6

Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in December is currently the most expensive (average of $671). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s optimal to fly from Panama City to Spain in the evening. By choosing this option you can save up to 18% on the cost of your flight, compared to a flight at noon.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 12, 2025.

The most flights from PTY to ES0 are scheduled on a Monday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

How often are flights from Panama City to Spain delayed?

About 14% of weekly flights between Panama City and Spain have experienced delays in the past year, with the average delay time being 133 minutes.

What is the most punctual flight time for Panama City to Spain flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Monday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama City to Spain flights?

Over the last year, Pascan have had the lowest number of delays on this route, with just 6% of flights being delayed.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated December 12, 2025.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Air Europa from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,504 reviews

Food

7.0

Boarding

7.4

Entertainment

7.0

Overall

7.4

Comfort

7.3

Crew

8.2

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Air France
7.4
Good
1,504 reviews
Air France
7.4
Good
1,504 reviews

Food

7.0

Boarding

7.4

Entertainment

7.0

Overall

7.4

Comfort

7.3

Crew

8.2

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Turkish Airlines
7.3
Good
4,090 reviews
Air France
7.4
Good
1,504 reviews

Food

7.0

Boarding

7.4

Entertainment

7.0

Overall

7.4

Comfort

7.3

Crew

8.2

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Air Europa
7.0
Good
571 reviews
Air France
7.4
Good
1,504 reviews

Food

7.0

Boarding

7.4

Entertainment

7.0

Overall

7.4

Comfort

7.3

Crew

8.2

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Iberia
7.0
Good
3,045 reviews
Air France
7.4
Good
1,504 reviews

Food

7.0

Boarding

7.4

Entertainment

7.0

Overall

7.4

Comfort

7.3

Crew

8.2

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Avianca
6.6
Okay
2,480 reviews
Air France
7.4
Good
1,504 reviews

Food

7.0

Boarding

7.4

Entertainment

7.0

Overall

7.4

Comfort

7.3

Crew

8.2

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 20 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Spain?

    Air Europa, KLM, and Turkish Airlines can get you from Panama City to Spain in just under 9h 35m. Your travel time can differ by up to 27h 50m. Panama City and Spain are separated by a distance of 5065 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Air Europa, which is currently one of the cheapest options available, starting at $419. Turkish Airlines flights start at $434 while deals on Avianca start at $535 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Granadilla Tenerife-Sur when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Qatar Airways (77%), Iberia (77%) or EL AL (77%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,380 for a flight from Panama City to Spain. The cheapest flight overall is $540 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $698.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $155). Flying from Panama City to Spain in December is currently the most expensive (average of $671). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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Top 8 airlines flying from Panama City to Spain

Discover the top 8 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$614Average$959FlexibilityNo cancel feeOn-time71%
KLMCheapest$654Average$933FlexibilityNo cancel feeOn-time75%
Air EuropaCheapest$665Average$853FlexibilityNo cancel feeOn-time83%
IberiaCheapest$677Average$924FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$697Average$822FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$698Average$774FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$700Average$891FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$728Average$1,262FlexibilityNo cancel feeOn-time70%

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