HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$161+ Cheap flights from Santo Domingo (SDQ) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — CHS
Feb 7 — Feb 141
Sat 2/7
Sat 2/14
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santo Domingo to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santo Domingo to South Carolina

Keep the following information in mind while searching for Santo Domingo to South Carolina flight deals. Data was last updated January 8, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$281
(Cheapflightsfares)

One-way from

$161
(Kiwi.com)
Provider with most accurate pricing for Santo Domingo Las Americas-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Myrtle Beach Intl flights.
Search Deals
From Santo Domingo Las Americas to South Carolina
Search Deals
One-way flight from Santo Domingo Las Americas to South Carolina
Search Deals

Find flight deals from Santo Domingo to South Carolina

Cheapest flights from Santo Domingo to South Carolina
Explore the most affordable flight options available from Santo Domingo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This Cheapflightsfares deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/233:32 pmSDQ - CLT
1 stop10h 08mSpirit Airlines
Sat 1/316:00 amCLT - SDQ
1 stop7h 27mSpirit Airlines
Deal found 1/6$281
This Kiwi.com deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/251:57 pmSDQ - CLT
1 stop28h 39mMultiple Airlines
Sun 2/152:01 pmCLT - SDQ
1 stop25h 28mMultiple Airlines
Deal found 1/8$303
This Cheapflightsfares deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/223:32 pmSDQ - CLT
1 stop10h 08mSpirit Airlines
Sun 2/16:00 amCLT - SDQ
1 stop7h 27mSpirit Airlines
Deal found 1/7$313
This Kiwi.com deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/2411:14 amSDQ - CLT
1 stop6h 40mMultiple Airlines
Sun 2/152:01 pmCLT - SDQ
1 stop25h 28mMultiple Airlines
Deal found 1/8$319
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/233:32 pmSDQ - CLT
1 stop10h 08mMultiple Airlines
Sat 1/319:59 pmCLT - SDQ
2 stops21h 12mMultiple Airlines
Deal found 1/6$321
This CheapOair deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/233:32 pmSDQ - CLT
1 stop10h 08mSpirit Airlines
Sun 2/16:00 amCLT - SDQ
1 stop7h 27mSpirit Airlines
Deal found 1/7$328
This CheapOair deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/243:32 pmSDQ - CLT
1 stop10h 08mSpirit Airlines
Tue 1/276:00 amCLT - SDQ
1 stop7h 27mSpirit Airlines
Deal found 1/6$334
This CheapOair deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/213:32 pmSDQ - CLT
1 stop10h 08mSpirit Airlines
Sun 1/256:00 amCLT - SDQ
1 stop7h 27mSpirit Airlines
Deal found 1/6$335
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/213:32 pmSDQ - CLT
1 stop23h 05mMultiple Airlines
Sat 2/285:49 pmCLT - SDQ
1 stop14h 50mMultiple Airlines
Deal found 1/7$339
This JetBlue deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/299:50 pmSDQ - CHS
1 stop12h 30mJetBlue
Mon 2/210:10 amCHS - SDQ
1 stop9h 15mJetBlue
Deal found 1/6$345
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:55 pmSDQ - CHS
1 stop18h 52mAmerican Airlines
Mon 5/48:09 pmCHS - SDQ
1 stop13h 11mAmerican Airlines
Deal found 1/7$352
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/106:29 pmSDQ - CHS
1 stop15h 14mAmerican Airlines
Wed 5/138:09 pmCHS - SDQ
1 stop13h 11mAmerican Airlines
Deal found 1/6$510

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Santo Domingo

Fly to

South Carolina

Route

Depart

Return

Price

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Fri 1/23

3:32 pm-12:40 am

1 stop10h 08m

Charlotte Douglas

Sat 1/31

6:00 am-2:27 pm

1 stop7h 27m

$281

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Thu 1/22

3:32 pm-12:40 am

1 stop10h 08m

Charlotte Douglas

Sun 2/1

6:00 am-2:27 pm

1 stop7h 27m

$313

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Sat 1/24

11:14 am-4:54 pm

1 stop6h 40m

Charlotte Douglas

Sun 2/15

2:01 pm-4:29 pm

1 stop25h 28m

$319

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Fri 1/23

3:32 pm-12:40 am

1 stop10h 08m

Charlotte Douglas

Sun 2/1

6:00 am-2:27 pm

1 stop7h 27m

$328

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Wed 1/21

3:32 pm-12:40 am

1 stop10h 08m

Charlotte Douglas

Sun 1/25

6:00 am-2:27 pm

1 stop7h 27m

$335

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 1/29

9:50 pm-9:20 am

1 stop12h 30m

Charleston

Mon 2/2

10:10 am-8:25 pm

1 stop9h 15m

$345

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

4:00 pm-10:24 am

1 stop18h 24m

Charleston

Mon 5/4

11:04 am-10:52 pm

1 stop11h 48m

$352

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Thu 2/5

3:32 pm-12:40 am

1 stop10h 08m

Charlotte Douglas

Wed 2/18

5:55 am-2:20 pm

1 stop7h 25m

$356

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Tue 1/20

11:14 am-10:40 am

1 stop24h 26m

Charlotte Douglas

Fri 2/6

6:02 pm-2:27 pm

1 stop19h 25m

$362

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Thu 1/15

4:24 pm-6:13 pm

2 stops26h 49m

Charlotte Douglas

Sun 2/1

7:00 am-11:20 pm

1 stop15h 20m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/5

Showing 1-10 of 34 results
1
2
3
4

Best time to book a flight from Santo Domingo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to South Carolina
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 8, 2026.
Peruse reviews from past customers who have flown with Delta from Santo Domingo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,025 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,025 reviews
Delta
7.9
Good
8,025 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to South Carolina?

    Santo Domingo Las Americas (SDQ) is the airport you will fly out of if you book a flight from Santo Domingo to South Carolina. It is only a 17.5 mi journey to Las Americas (SDQ) from Santo Domingo’s city center.

  • How long is the flight from Santo Domingo to South Carolina?

    Spirit Airlines, JetBlue, and American Airlines can get you from Santo Domingo to South Carolina in just under 10h 08m. Your travel time can differ by up to 8h 16m. The distance between Santo Domingo and South Carolina is about 1349 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santo Domingo to South Carolina?

    While some choose either Santo Domingo Las Americas - Charleston or Santo Domingo Las Americas - Columbia Metropolitan, Santo Domingo Las Americas - Charlotte Douglas is the most popular route from Santo Domingo to South Carolina.

  • Can I find deals for flights from Santo Domingo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to South Carolina.

  • Can I find deals for business class flights from Santo Domingo to South Carolina?

    Yes. Cheapflights offers flight deals from Santo Domingo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to John F Kennedy Intl flights
Punta Cana to Orlando flights
Santo Domingo to Newark flights
Punta Cana to Newark flights
Punta Cana to John F Kennedy Intl flights
Santo Domingo to Fort Lauderdale flights
Punta Cana to O'Hare Intl flights
Santo Domingo to Miami flights
Santo Domingo to LaGuardia flights
Punta Cana to LaGuardia flights
Punta Cana to Fort Lauderdale flights
Punta Cana to Miami flights
Punta Cana to Midway flights
Santo Domingo to Boston flights
Santiago de los Caballeros to John F Kennedy Intl flights
Santiago de los Caballeros to Newark flights
Santo Domingo to Orlando flights
Santo Domingo to Atlanta flights
Santiago de los Caballeros to LaGuardia flights
Santiago de los Caballeros to Orlando flights
Santo Domingo to Philadelphia flights
Punta Cana to Baltimore flights
Santiago de los Caballeros to Boston flights
Santiago de los Caballeros to Miami flights
Santo Domingo to Las Vegas flights
Punta Cana to Dulles Intl flights
Punta Cana to West Palm Beach flights
Santo Domingo to Dallas/Fort Worth flights
Santiago de los Caballeros to Fort Lauderdale flights
Santo Domingo to Los Angeles flights
Santo Domingo to O'Hare Intl flights
Santo Domingo to Tampa flights
Punta Cana to Boston flights
Santiago de los Caballeros to Philadelphia flights
Santo Domingo to Baltimore flights
Puerto Plata to John F Kennedy Intl flights
Santo Domingo to Reagan-National flights
Santo Domingo to Dulles Intl flights
Punta Cana to Hobby flights
Santo Domingo to West Palm Beach flights
Santo Domingo to Charlotte flights
Santo Domingo to Salt Lake City flights
Punta Cana to Atlanta flights
Punta Cana to Reagan-National flights
Santo Domingo to Hobby flights
Santo Domingo to Atlantic City flights
Santo Domingo to George Bush Intcntl flights
Punta Cana to Los Angeles flights
Punta Cana to George Bush Intcntl flights

Top airline flying from Santo Domingo to South Carolina

Discover the top airline that operate flights from Santo Domingo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$494Average$494FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.