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South Carolina

$168+ Cheap flights from Santo Domingo (SDQ) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/29. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — CHS
ene. 8 — ene. 151
jue. 1/8
jue. 1/15
1 adult, Economy
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Cheap flight deals from Santo Domingo to South Carolina

Cheapest flights from Santo Domingo to South Carolina
Explore the most affordable flight options available from Santo Domingo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 9, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/193:59 amSDQ - CLT
1 stop11h 03mMultiple Airlines
mié. 12/319:00 amCLT - SDQ
1 stop16h 54mMultiple Airlines
Deal found 12/7$331
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/226:04 pmSDQ - CLT
1 stop22h 52mMultiple Airlines
dom. 12/2810:34 amCLT - SDQ
1 stop29h 15mMultiple Airlines
Deal found 12/9$335
This eDestinos deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/208:20 amSDQ - CLT
1 stop13h 19mSpirit Airlines
sáb. 1/311:08 amCLT - SDQ
1 stop14h 46mSpirit Airlines
Deal found 12/7$341
This Frontier deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/2112:35 pmSDQ - CLT
1 stop9h 03mFrontier
vie. 1/29:04 pmCLT - SDQ
1 stop11h 57mFrontier
Deal found 12/7$343
This Kiwi.com deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/254:21 pmSDQ - CLT
1 stop8h 08mMultiple Airlines
dom. 1/111:30 pmCLT - SDQ
1 stop23h 12mMultiple Airlines
Deal found 12/7$344
This Frontier deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/2612:35 pmSDQ - CLT
1 stop8h 34mFrontier
jue. 1/88:46 pmCLT - SDQ
1 stop11h 55mFrontier
Deal found 12/8$345
This Frontier deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/2312:35 pmSDQ - CLT
1 stop8h 54mFrontier
dom. 1/410:26 amCLT - SDQ
1 stop8h 01mFrontier
Deal found 12/9$354
This eDestinos deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/184:21 pmSDQ - CLT
1 stop8h 08mSpirit Airlines
sáb. 1/37:00 amCLT - SDQ
1 stop7h 18mSpirit Airlines
Deal found 12/7$359
This Expedia deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/93:28 pmSDQ - CHS
1 stop18h 09mJetBlue
mar. 12/1610:51 amCHS - SDQ
1 stop13h 04mJetBlue
Deal found 12/8$593
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/214:49 pmSDQ - CAE
2 stops16h 50mAmerican Airlines
jue. 1/17:05 amCAE - SDQ
2 stops9h 46mAmerican Airlines
Deal found 12/9$593
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/2111:07 amSDQ - CAE
2 stops11h 51mAmerican Airlines
dom. 1/47:59 pmCAE - SDQ
2 stops13h 08mAmerican Airlines
Deal found 12/9$611
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/96:00 amSDQ - CHS
2 stops16h 06mAmerican Airlines
mar. 12/166:00 amCHS - SDQ
1 stop8h 58mAmerican Airlines
Deal found 12/8$632

Find flight deals from Santo Domingo to South Carolina

Keep the following information in mind while searching for Santo Domingo to South Carolina flight deals. Data was last updated diciembre 9, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$323
(Delta)

One-way from

$168
(Kiwi.com)
Provider with most accurate pricing for Santo Domingo Las Americas-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Myrtle Beach Intl flights.
Search Deals
From Santo Domingo Las Americas to South Carolina
Search Deals
One-way flight from Santo Domingo Las Americas to South Carolina
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 9, 2025.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Santo Domingo

Fly to

South Carolina

Route

Depart

Return

Price

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

mar. 2/10

7:30 am-8:55 pm

2 stops14h 25m

Charleston

mié. 2/18

12:00 pm-12:32 am

1 stop11h 32m

$323

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

mar. 2/10

4:40 pm-12:40 am

1 stop9h 00m

Charlotte Douglas

mié. 2/18

7:00 am-4:29 pm

1 stop8h 29m

$332

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

lun. 2/9

4:40 pm-12:40 am

1 stop9h 00m

Charlotte Douglas

jue. 2/19

7:00 am-3:32 pm

1 stop7h 32m

$342

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

vie. 5/1

3:25 pm-10:42 pm

1 stop7h 17m

Charleston

lun. 5/4

8:08 pm-10:50 am

1 stop14h 42m

$344

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

jue. 12/25

4:21 pm-11:29 pm

1 stop8h 08m

Charlotte Douglas

dom. 1/11

1:30 pm-1:42 pm

1 stop23h 12m

$344

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

lun. 2/9

12:41 pm-4:42 pm

2 stops29h 01m

Charlotte Douglas

jue. 2/19

7:03 pm-3:32 pm

1 stop19h 29m

$351

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

mar. 12/23

12:35 pm-8:29 pm

1 stop8h 54m

Charlotte Douglas

dom. 1/4

10:26 am-7:27 pm

1 stop8h 01m

$354

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

dom. 2/1

6:29 pm-9:48 am

2 stops16h 19m

Charleston

jue. 2/5

7:20 pm-12:21 pm

1 stop16h 01m

$354

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

mar. 2/10

6:00 am-9:08 pm

2 stops16h 08m

Charleston

mié. 2/18

6:10 am-4:00 pm

2 stops8h 50m

$357

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

vie. 1/23

4:40 pm-12:40 am

1 stop9h 00m

Charlotte Douglas

dom. 2/1

6:00 am-3:35 pm

1 stop8h 35m

$358

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/7

Showing 1-10 of 34 results
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Best time to book a flight from Santo Domingo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to South Carolina

What is the cheapest time of day to fly from SDQ to SC?

Find hourly flight availability from Santo Domingo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 9, 2025.

When flying from Santo Domingo to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 44% versus a flight in the morning.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated diciembre 9, 2025.
Peruse reviews from past customers who have flown with Delta from Santo Domingo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to South Carolina?

    Santo Domingo Las Americas (SDQ) is the airport you will fly out of if you book a flight from Santo Domingo to South Carolina. It is only a 17.5 mi journey to Las Americas (SDQ) from Santo Domingo’s city center.

  • How long is the flight from Santo Domingo to South Carolina?

    Delta, Spirit Airlines, and American Airlines can get you from Santo Domingo to South Carolina in just under 7h 17m. Your travel time can differ by up to 7h 08m. The distance between Santo Domingo and South Carolina is about 1187 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santo Domingo to South Carolina?

    While some choose either Santo Domingo Las Americas - Charleston or Santo Domingo Las Americas - Columbia Metropolitan, Santo Domingo Las Americas - Charlotte Douglas is the most popular route from Santo Domingo to South Carolina.

  • Can I find deals for flights from Santo Domingo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to South Carolina.

  • Can I find deals for business class flights from Santo Domingo to South Carolina?

    Yes. Cheapflights offers flight deals from Santo Domingo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Santo Domingo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Santiago de los Caballeros to Boston flights
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Santo Domingo to Tampa flights
Santiago de los Caballeros to Fort Lauderdale flights
Santo Domingo to Dallas/Fort Worth flights
Punta Cana to Atlanta flights
Santo Domingo to Charlotte flights
Punta Cana to Philadelphia flights
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Puerto Plata to Newark flights
Santo Domingo to West Palm Beach flights
Punta Cana to Hobby flights
Santo Domingo to Hobby flights
Santo Domingo to Dulles Intl flights
Santo Domingo to George Bush Intcntl flights
Santo Domingo to Baltimore flights
Santo Domingo to Salt Lake City flights
Puerto Plata to LaGuardia flights
Punta Cana to George Bush Intcntl flights
Punta Cana to West Palm Beach flights
Punta Cana to Baltimore flights
Punta Cana to Dulles Intl flights
Santo Domingo to Reagan-National flights

Top airline flying from Santo Domingo to South Carolina

Discover the top airline that operate flights from Santo Domingo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 9, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$494Average$494FlexibilityNo cancel feeOn-timeN/A

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