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$161+ Cheap flights from Santo Domingo (SDQ) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — CHS
dic. 25 — ene. 11
jue. 12/25
jue. 1/1
1 adult, Economy
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Cheap flight deals from Santo Domingo to South Carolina

Keep the following information in mind while searching for Santo Domingo to South Carolina flight deals. Data was last updated noviembre 25, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$301
(Kiwi.com)

One-way from

$161
(Kiwi.com)
Provider with most accurate pricing for Santo Domingo Las Americas-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Myrtle Beach Intl flights.
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From Santo Domingo Las Americas to South Carolina
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One-way flight from Santo Domingo Las Americas to South Carolina
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Find flight deals from Santo Domingo to South Carolina

Cheapest flights from Santo Domingo to South Carolina
Explore the most affordable flight options available from Santo Domingo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 25, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/223:59 amSDQ - CLT
1 stop17h 34mMultiple Airlines
mar. 12/307:46 pmCLT - SDQ
1 stop19h 43mMultiple Airlines
Deal found 11/23$313
This Priceline deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/174:21 pmSDQ - CLT
1 stop8h 38mMultiple Airlines
mié. 1/74:32 pmCLT - SDQ
1 stop16h 09mMultiple Airlines
Deal found 11/23$318
This CheapOair deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/193:59 amSDQ - CLT
1 stop6h 40mSpirit Airlines
sáb. 1/311:08 amCLT - SDQ
1 stop14h 46mSpirit Airlines
Deal found 11/25$320
This Kiwi.com deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/253:59 amSDQ - CLT
1 stop11h 13mMultiple Airlines
sáb. 1/38:54 amCLT - SDQ
1 stop17h 00mMultiple Airlines
Deal found 11/25$324
This Kiwi.com deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/226:04 pmSDQ - CLT
1 stop22h 52mMultiple Airlines
dom. 1/111:30 pmCLT - SDQ
1 stop23h 12mMultiple Airlines
Deal found 11/22$325
This Cheapflightsfares deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/218:20 amSDQ - CLT
1 stop13h 19mSpirit Airlines
vie. 1/27:00 amCLT - SDQ
1 stop7h 23mSpirit Airlines
Deal found 11/25$335
This Priceline deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/293:59 amSDQ - CLT
1 stop6h 40mMultiple Airlines
dom. 1/48:18 pmCLT - SDQ
1 stop13h 52mMultiple Airlines
Deal found 11/25$336
This Mytrip deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/308:20 amSDQ - CLT
1 stop13h 19mMultiple Airlines
lun. 1/59:43 pmCLT - SDQ
1 stop13h 57mMultiple Airlines
Deal found 11/23$337
This CheapOair deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/193:59 amSDQ - CLT
1 stop6h 40mSpirit Airlines
dom. 1/47:00 amCLT - SDQ
1 stop7h 23mSpirit Airlines
Deal found 11/25$340
This Frontier deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/2011:16 amSDQ - CLT
1 stop9h 53mFrontier
sáb. 1/310:38 pmCLT - SDQ
1 stop11h 32mFrontier
Deal found 11/25$343
This American Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/61:28 pmSDQ - CHS
1 stop12h 18mAmerican Airlines
lun. 12/86:00 amCHS - SDQ
1 stop10h 23mAmerican Airlines
Deal found 11/23$429
This Delta deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/66:35 amSDQ - CHS
2 stops13h 53mDelta
lun. 12/85:25 amCHS - SDQ
2 stops12h 53mDelta
Deal found 11/23$548

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 25, 2025.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Santo Domingo

Fly to

South Carolina

Route

Depart

Return

Price

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

mar. 12/30

8:20 am-8:39 pm

1 stop13h 19m

Charlotte Douglas

dom. 1/4

10:26 am-7:27 pm

1 stop8h 01m

$338

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

sáb. 1/31

9:50 pm-9:20 am

1 stop12h 30m

Charleston

lun. 2/2

10:10 am-8:21 pm

1 stop9h 11m

$344

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

vie. 5/1

7:55 am-10:42 pm

1 stop14h 47m

Charleston

lun. 5/4

11:17 am-9:50 pm

1 stop10h 33m

$344

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

mié. 12/17

4:21 pm-11:59 pm

1 stop8h 38m

Charlotte Douglas

mié. 1/7

7:00 am-3:23 pm

1 stop7h 23m

$344

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

vie. 12/26

12:35 pm-8:09 pm

1 stop8h 34m

Charlotte Douglas

jue. 1/8

8:46 pm-9:41 am

1 stop11h 55m

$345

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

dom. 12/21

3:59 am-2:12 pm

1 stop11h 13m

Charlotte Douglas

dom. 1/11

3:15 pm-1:42 pm

2 stops21h 27m

$355

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

vie. 12/19

12:25 pm-7:29 pm

1 stop8h 04m

Charlotte Douglas

mar. 12/23

7:46 pm-4:49 pm

1 stop20h 03m

$356

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

lun. 12/29

8:20 am-8:39 pm

1 stop13h 19m

Charlotte Douglas

mié. 12/31

7:00 am-3:32 am

2 stops19h 32m

$377

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

dom. 12/21

12:35 pm-7:59 am

2 stops20h 24m

Charlotte Douglas

vie. 1/2

10:38 pm-11:10 am

1 stop11h 32m

$377

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

lun. 12/15

4:21 pm-11:59 pm

1 stop8h 38m

Charlotte Douglas

vie. 1/2

7:00 am-3:23 pm

1 stop7h 23m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/25

Showing 1-10 of 28 results
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Best time to book a flight from Santo Domingo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to South Carolina

What is the cheapest time of day to fly from SDQ to SC?

Find hourly flight availability from Santo Domingo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 25, 2025.

When flying from Santo Domingo to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 44% versus a flight in the morning.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated noviembre 25, 2025.
Peruse reviews from past customers who have flown with Delta from Santo Domingo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,999 reviews

Overall

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
7,999 reviews
Delta
7.9
Good
7,999 reviews

Overall

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to South Carolina?

    Santo Domingo Las Americas (SDQ) is the airport you will fly out of if you book a flight from Santo Domingo to South Carolina. It is only a 17.5 mi journey to Las Americas (SDQ) from Santo Domingo’s city center.

  • How long is the flight from Santo Domingo to South Carolina?

    JetBlue, American Airlines, and Spirit Airlines can get you from Santo Domingo to South Carolina in just under 8h 38m. Your travel time can differ by up to 6h 09m. The distance between Santo Domingo and South Carolina is about 1349 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santo Domingo to South Carolina?

    While some choose either Santo Domingo Las Americas - Charleston or Santo Domingo Las Americas - Columbia Metropolitan, Santo Domingo Las Americas - Charlotte Douglas is the most popular route from Santo Domingo to South Carolina.

  • Can I find deals for flights from Santo Domingo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to South Carolina.

  • Can I find deals for business class flights from Santo Domingo to South Carolina?

    Yes. Cheapflights offers flight deals from Santo Domingo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Santo Domingo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Santiago de los Caballeros to Fort Lauderdale flights
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Punta Cana to Baltimore flights
Punta Cana to Dulles Intl flights
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Punta Cana to Hobby flights
Santo Domingo to Reagan-National flights
Santo Domingo to Hobby flights
Santiago de los Caballeros to Philadelphia flights
Santo Domingo to Midway flights
Punta Cana to George Bush Intcntl flights
Punta Cana to West Palm Beach flights
Punta Cana to Detroit flights
Santo Domingo to George Bush Intcntl flights
Santo Domingo to Raleigh flights
Puerto Plata to Newark flights

Top airline flying from Santo Domingo to South Carolina

Discover the top airline that operate flights from Santo Domingo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$494Average$494FlexibilityNo cancel feeOn-timeN/A

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