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South Carolina

$182+ Cheap flights from Santo Domingo (SDQ) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — CHS
Dec 18 — Dec 251
Thu 12/18
Thu 12/25
1 adult, Economy
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Cheap flight deals from Santo Domingo to South Carolina

Keep the following information in mind while searching for Santo Domingo to South Carolina flight deals. Data was last updated November 18, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$295
(Booking.com)

One-way from

$182
(JetBlue)
Provider with most accurate pricing for Santo Domingo Las Americas-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Myrtle Beach Intl flights.
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From Santo Domingo Las Americas to South Carolina
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One-way flight from Santo Domingo Las Americas to South Carolina
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Find flight deals from Santo Domingo to South Carolina

Cheapest flights from Santo Domingo to South Carolina
Explore the most affordable flight options available from Santo Domingo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 18, 2025.

This Booking.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:21 pmSDQ - CLT
1 stop8h 08mSpirit Airlines
Thu 1/19:00 amCLT - SDQ
1 stop5h 23mSpirit Airlines
Deal found 11/18$295
This CheapOair deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/254:21 pmSDQ - CLT
1 stop8h 08mSpirit Airlines
Tue 12/309:00 amCLT - SDQ
1 stop5h 23mSpirit Airlines
Deal found 11/17$301
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:04 pmSDQ - CLT
1 stop22h 52mMultiple Airlines
Thu 1/87:00 amCLT - SDQ
1 stop7h 35mMultiple Airlines
Deal found 11/16$337
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:59 amSDQ - CLT
1 stop17h 34mSpirit Airlines
Fri 1/29:38 pmCLT - SDQ
1 stop28h 16mSpirit Airlines
Deal found 11/18$342
This Cheapflightsfares deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/193:59 amSDQ - CLT
1 stop6h 40mSpirit Airlines
Sun 1/47:00 amCLT - SDQ
1 stop7h 23mSpirit Airlines
Deal found 11/18$344
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/273:35 pmSDQ - CLT
1 stop18h 43mMultiple Airlines
Mon 12/88:55 amCLT - SDQ
1 stop5h 28mMultiple Airlines
Deal found 11/16$353
This Spirit Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:20 amSDQ - CLT
1 stop13h 19mSpirit Airlines
Wed 12/319:00 amCLT - SDQ
1 stop5h 23mSpirit Airlines
Deal found 11/17$356
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:59 amSDQ - CLT
1 stop17h 34mMultiple Airlines
Fri 1/210:38 pmCLT - SDQ
2 stops27h 16mMultiple Airlines
Deal found 11/18$360
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/181:19 pmSDQ - CHS
1 stop6h 58mAmerican Airlines
Tue 11/256:00 amCHS - SDQ
1 stop10h 08mAmerican Airlines
Deal found 11/17$367
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/186:45 amSDQ - CHS
2 stops11h 38mDelta
Tue 11/2512:51 pmCHS - SDQ
2 stops11h 45mDelta
Deal found 11/17$412
This JetBlue deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/174:09 amSDQ - CHS
1 stop10h 10mJetBlue
Tue 11/258:24 amCHS - SDQ
1 stop4h 58mJetBlue
Deal found 11/17$619
This Mytrip deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1812:20 pmSDQ - CHS
3 stops31h 40mMultiple Airlines
Tue 11/256:50 amCHS - SDQ
2 stops21h 35mMultiple Airlines
Deal found 11/17$2,182

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 18, 2025.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Santo Domingo

Fly to

South Carolina

Route

Depart

Return

Price

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Thu 12/25

4:21 pm-11:29 pm

1 stop8h 08m

Charlotte Douglas

Tue 12/30

9:00 am-3:23 pm

1 stop5h 23m

$301

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Fri 1/30

10:19 am-12:22 pm

1 stop27h 03m

Charlotte Douglas

Mon 2/9

6:56 pm-3:35 pm

1 stop19h 39m

$351

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Mon 12/29

8:20 am-8:39 pm

1 stop13h 19m

Charlotte Douglas

Wed 12/31

9:00 am-3:23 pm

1 stop5h 23m

$356

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 2/5

7:31 am-5:13 pm

1 stop10h 42m

Charleston

Sat 2/7

6:00 am-7:14 pm

1 stop12h 14m

$358

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

3:25 pm-10:42 pm

1 stop7h 17m

Charleston

Mon 5/4

11:17 am-7:45 pm

1 stop8h 28m

$358

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Sat 12/20

8:20 am-8:39 pm

1 stop13h 19m

Charlotte Douglas

Sat 1/3

7:00 am-3:18 pm

1 stop7h 18m

$385

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Mon 12/15

10:19 am-12:41 pm

1 stop27h 22m

Charlotte Douglas

Fri 1/2

9:04 pm-10:01 am

1 stop11h 57m

$395

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Thu 12/25

3:59 am-9:39 am

1 stop6h 40m

Charlotte Douglas

Thu 1/8

7:00 am-3:35 pm

1 stop7h 35m

$397

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Sun 12/7

4:21 pm-11:59 pm

1 stop8h 38m

Charlotte Douglas

Tue 12/9

8:55 am-3:23 pm

1 stop5h 28m

$411

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Tue 3/31

3:37 pm-12:40 am

1 stop9h 03m

Charlotte Douglas

Tue 4/7

6:00 am-2:32 pm

1 stop8h 32m

$418

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/18

Showing 1-10 of 33 results
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Best time to book a flight from Santo Domingo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to South Carolina

What is the cheapest time of day to fly from SDQ to SC?

Find hourly flight availability from Santo Domingo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 18, 2025.

When flying from Santo Domingo to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 44% versus a flight in the morning.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 18, 2025.
Peruse reviews from past customers who have flown with Delta from Santo Domingo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,003 reviews

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,003 reviews
Delta
7.9
Good
8,003 reviews

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to South Carolina?

    Santo Domingo Las Americas (SDQ) is the airport you will fly out of if you book a flight from Santo Domingo to South Carolina. It is only a 17.5 mi journey to Las Americas (SDQ) from Santo Domingo’s city center.

  • How long is the flight from Santo Domingo to South Carolina?

    Spirit Airlines, Delta, and American Airlines can get you from Santo Domingo to South Carolina in just under 7h 17m. Your travel time can differ by up to 3h 25m. The distance between Santo Domingo and South Carolina is about 1187 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Santo Domingo to South Carolina one-way?

    To fly one-way, consider booking your trip with JetBlue, which is currently one of the cheapest options available, starting at $182. Delta flights start at $187 while deals on Spirit Airlines start at $193 one-way.

  • What are the most popular routes from Santo Domingo to South Carolina?

    While some choose either Santo Domingo Las Americas - Columbia Metropolitan or Santo Domingo Las Americas - Charleston, Santo Domingo Las Americas - Charlotte Douglas is the most popular route from Santo Domingo to South Carolina.

  • Can I find deals for flights from Santo Domingo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to South Carolina.

  • Can I find deals for business class flights from Santo Domingo to South Carolina?

    Yes. Cheapflights offers flight deals from Santo Domingo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Santo Domingo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Santo Domingo to South Carolina

Discover the top airline that operate flights from Santo Domingo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$494Average$494FlexibilityNo cancel feeOn-timeN/A

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