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$133+ Cheap flights from Santo Domingo (SDQ) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — CHS
dic. 4 — dic. 111
jue. 12/4
jue. 12/11
1 adult, Economy
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Cheap flight deals from Santo Domingo to South Carolina

Keep the following information in mind while searching for Santo Domingo to South Carolina flight deals. Data was last updated noviembre 4, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$323
(CheapOair)

One-way from

$133
(Cheapflightsfares)
Provider with most accurate pricing for Santo Domingo Las Americas-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Myrtle Beach Intl flights.
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From Santo Domingo Las Americas to South Carolina
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One-way flight from Santo Domingo Las Americas to South Carolina
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Find flight deals from Santo Domingo to South Carolina

Cheapest flights from Santo Domingo to South Carolina
Explore the most affordable flight options available from Santo Domingo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 4, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/234:35 pmSDQ - CLT
1 stop17h 47mMultiple Airlines
mar. 12/93:42 pmCLT - SDQ
1 stop23h 47mMultiple Airlines
Deal found 11/3$327
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/234:35 pmSDQ - CLT
1 stop17h 47mSpirit Airlines
lun. 12/87:00 amCLT - SDQ
1 stop7h 23mSpirit Airlines
Deal found 11/3$332
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/203:35 pmSDQ - CLT
1 stop18h 43mMultiple Airlines
lun. 11/245:59 pmCLT - SDQ
1 stop20h 31mMultiple Airlines
Deal found 11/4$338
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/234:35 pmSDQ - CLT
1 stop17h 47mSpirit Airlines
dom. 12/77:00 amCLT - SDQ
1 stop7h 23mSpirit Airlines
Deal found 11/3$342
This Priceline deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/612:49 pmSDQ - CLT
1 stop12h 10mSpirit Airlines
sáb. 12/137:00 amCLT - SDQ
1 stop7h 23mSpirit Airlines
Deal found 11/4$346
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/234:35 pmSDQ - CLT
1 stop17h 47mMultiple Airlines
jue. 12/111:57 pmCLT - SDQ
1 stop6h 48mMultiple Airlines
Deal found 11/3$354
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/274:35 pmSDQ - CLT
1 stop17h 47mSpirit Airlines
mié. 12/35:59 pmCLT - SDQ
1 stop20h 24mSpirit Airlines
Deal found 11/3$358
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/204:35 pmSDQ - CLT
3 stops22h 31mSpirit Airlines
lun. 11/247:30 amCLT - SDQ
1 stop7h 00mSpirit Airlines
Deal found 11/4$361
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/244:35 pmSDQ - CLT
1 stop22h 31mSpirit Airlines
lun. 12/87:00 amCLT - SDQ
1 stop7h 23mSpirit Airlines
Deal found 11/3$365
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/234:35 pmSDQ - CLT
1 stop17h 47mMultiple Airlines
mié. 12/1012:59 pmCLT - SDQ
1 stop15h 26mMultiple Airlines
Deal found 11/3$366
This CheapOair deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/184:21 pmSDQ - CLT
1 stop8h 08mSpirit Airlines
sáb. 1/311:08 amCLT - SDQ
1 stop14h 46mSpirit Airlines
Deal found 11/4$371
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/43:06 pmSDQ - CAE
2 stops9h 40mAmerican Airlines
jue. 12/186:09 amCAE - SDQ
2 stops10h 42mAmerican Airlines
Deal found 11/4$1,065

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 4, 2025.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Santo Domingo

Fly to

South Carolina

Route

Depart

Return

Price

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

jue. 11/20

3:35 pm-9:18 am

1 stop18h 43m

Charlotte Douglas

lun. 11/24

5:59 pm-3:30 pm

1 stop20h 31m

$338

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

jue. 2/5

2:33 pm-10:22 pm

1 stop8h 49m

Charleston

sáb. 2/7

6:00 am-12:32 am

1 stop17h 32m

$339

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

vie. 5/1

1:28 pm-10:42 pm

1 stop9h 14m

Charleston

lun. 5/4

11:17 am-7:45 pm

1 stop8h 28m

$358

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

sáb. 12/20

4:23 pm-11:29 pm

1 stop8h 06m

Charlotte Douglas

mié. 1/7

9:38 pm-3:35 pm

1 stop16h 57m

$366

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

vie. 12/26

8:20 am-8:39 pm

1 stop13h 19m

Charlotte Douglas

jue. 1/8

9:49 am-5:50 pm

1 stop7h 01m

$380

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

mar. 12/30

8:20 am-11:29 pm

2 stops16h 09m

Charlotte Douglas

mar. 1/6

9:00 am-2:54 am

1 stop16h 54m

$405

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

dom. 12/21

12:35 pm-8:38 pm

1 stop9h 03m

Charlotte Douglas

vie. 1/2

2:51 pm-10:01 am

1 stop18h 10m

$410

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

vie. 12/19

3:59 am-9:39 am

1 stop6h 40m

Charlotte Douglas

sáb. 1/3

7:00 am-3:18 pm

1 stop7h 18m

$413

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

jue. 1/22

6:55 pm-12:59 am

1 stop7h 04m

Charlotte Douglas

dom. 2/1

5:45 am-1:39 am

2 stops18h 54m

$423

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

jue. 12/18

4:21 pm-11:29 pm

1 stop8h 08m

Charlotte Douglas

sáb. 1/3

7:00 am-3:18 pm

1 stop7h 18m

$438

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 32 results
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Best time to book a flight from Santo Domingo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to South Carolina

What is the cheapest time of day to fly from SDQ to SC?

Find hourly flight availability from Santo Domingo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 4, 2025.

When flying from Santo Domingo to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 44% versus a flight in the morning.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated noviembre 4, 2025.
Peruse reviews from past customers who have flown with Delta from Santo Domingo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,003 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,003 reviews
Delta
7.9
Good
8,003 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to South Carolina?

    Santo Domingo Las Americas (SDQ) is the airport you will fly out of if you book a flight from Santo Domingo to South Carolina. It is only a 17.5 mi journey to Las Americas (SDQ) from Santo Domingo’s city center.

  • How long is the flight from Santo Domingo to South Carolina?

    Delta, American Airlines, and Spirit Airlines can get you from Santo Domingo to South Carolina in just under 8h 06m. Your travel time can differ by up to 1h 08m. The distance between Santo Domingo and South Carolina is about 1349 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santo Domingo to South Carolina?

    While some choose either Santo Domingo Las Americas - Charleston or Santo Domingo Las Americas - Columbia Metropolitan, Santo Domingo Las Americas - Charlotte Douglas is the most popular route from Santo Domingo to South Carolina.

  • Can I find deals for flights from Santo Domingo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to South Carolina.

  • Can I find deals for business class flights from Santo Domingo to South Carolina?

    Yes. Cheapflights offers flight deals from Santo Domingo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Santo Domingo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Punta Cana to Dulles Intl flights
Santiago de los Caballeros to Fort Lauderdale flights
Santo Domingo to Seattle flights
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Punta Cana to Baltimore flights
Punta Cana to Hobby flights
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Santo Domingo to Austin flights
Santiago de los Caballeros to Philadelphia flights
Puerto Plata to LaGuardia flights
Punta Cana to Dallas/Fort Worth flights
Santo Domingo to New Orleans flights
Santiago de los Caballeros to Salt Lake City flights

Top airline flying from Santo Domingo to South Carolina

Discover the top airline that operate flights from Santo Domingo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$494Average$494FlexibilityNo cancel feeOn-timeN/A

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