HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$147+ Cheap flights from Santo Domingo (SDQ) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — CHS
Mar 25 — Apr 11
Wed 3/25
Wed 4/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santo Domingo to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santo Domingo to South Carolina

Cheapest flights from Santo Domingo to South Carolina
Explore the most affordable flight options available from Santo Domingo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.

This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/82:20 pm
SDQ
-
CLT
1 stop10h 18m
Spirit Airlines
Wed 4/226:00 am
CLT
-
SDQ
1 stop8h 39m
Spirit Airlines
Deal found 2/21$295
This FlightHub deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/262:20 pm
SDQ
-
CLT
1 stop5h 57m
Spirit Airlines
Thu 4/99:00 pm
CLT
-
SDQ
1 stop16h 15m
Spirit Airlines
Deal found 2/20$297
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:20 pm
SDQ
-
CLT
1 stop10h 18m
Multiple Airlines
Thu 4/163:08 pm
CLT
-
SDQ
1 stop8h 04m
Multiple Airlines
Deal found 2/21$301
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/910:46 am
SDQ
-
CLT
1 stop21h 17m
Multiple Airlines
Mon 3/231:20 pm
CLT
-
SDQ
1 stop12h 18m
Multiple Airlines
Deal found 2/22$305
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:44 pm
SDQ
-
CLT
1 stop6h 49m
Multiple Airlines
Tue 5/262:44 pm
CLT
-
SDQ
1 stop25h 45m
Multiple Airlines
Deal found 2/20$306
This Expedia deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/203:09 pm
SDQ
-
CHS
1 stop7h 29m
Spirit Airlines
Wed 9/27:00 am
CHS
-
SDQ
1 stop7h 04m
Spirit Airlines
Deal found 2/20$310
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/611:46 am
SDQ
-
CLT
1 stop22h 14m
Multiple Airlines
Sun 3/159:18 am
CLT
-
SDQ
1 stop30h 50m
Multiple Airlines
Deal found 2/22$312
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:20 pm
SDQ
-
CLT
1 stop10h 18m
Spirit Airlines
Fri 4/246:00 am
CLT
-
SDQ
1 stop8h 39m
Spirit Airlines
Deal found 2/20$313
This CheapOair deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/262:52 am
SDQ
-
CLT
1 stop17h 25m
Spirit Airlines
Tue 4/79:00 pm
CLT
-
SDQ
1 stop16h 15m
Spirit Airlines
Deal found 2/21$315
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/62:52 am
SDQ
-
CLT
1 stop29h 29m
Spirit Airlines
Thu 5/146:00 am
CLT
-
SDQ
1 stop8h 39m
Spirit Airlines
Deal found 2/22$318
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/610:19 am
SDQ
-
CLT
1 stop14h 06m
Multiple Airlines
Mon 4/136:45 am
CLT
-
SDQ
1 stop9h 44m
Multiple Airlines
Deal found 2/20$320
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/82:20 pm
SDQ
-
CHS
1 stop7h 53m
Multiple Airlines
Wed 4/153:26 pm
CHS
-
SDQ
1 stop14h 03m
Multiple Airlines
Deal found 2/21$336

Find flight deals from Santo Domingo to South Carolina

Keep the following information in mind while searching for Santo Domingo to South Carolina flight deals. Data was last updated February 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$295
(Mytrip)

One-way from

$147
(Cheapflightsfares)
Provider with most accurate pricing for Santo Domingo Las Americas-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Myrtle Beach Intl flights.
Search Deals
From Santo Domingo Las Americas to South Carolina
Search Deals
One-way flight from Santo Domingo Las Americas to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Santo Domingo

Fly to

South Carolina

Route

Depart

Return

Price

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Fri 3/6

11:46 am-9:00 am

1 stop22h 14m

Charlotte Douglas

Sun 3/15

9:18 am-4:08 pm

1 stop30h 50m

$312

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Mon 4/6

10:19 am-12:25 am

1 stop14h 06m

Charlotte Douglas

Mon 4/13

6:45 am-4:29 pm

1 stop9h 44m

$320

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Mon 3/23

2:52 am-8:17 pm

1 stop17h 25m

Charlotte Douglas

Fri 4/24

6:00 am-2:39 pm

1 stop8h 39m

$323

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Mon 3/30

2:52 am-8:17 pm

1 stop17h 25m

Charlotte Douglas

Tue 4/7

9:00 pm-1:15 pm

1 stop16h 15m

$326

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Mon 4/20

3:44 pm-10:33 pm

1 stop6h 49m

Charlotte Douglas

Fri 5/29

6:00 am-2:39 pm

1 stop8h 39m

$332

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 4/8

2:20 pm-10:13 pm

1 stop7h 53m

Charleston

Wed 4/15

3:26 pm-5:29 am

1 stop14h 03m

$336

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 5/14

2:45 pm-10:56 pm

1 stop8h 11m

Charleston

Tue 9/8

6:00 am-6:04 pm

1 stop12h 04m

$338

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Tue 4/21

3:44 pm-10:33 pm

1 stop6h 49m

Charlotte Douglas

Tue 5/26

3:09 pm-4:29 pm

2 stops25h 20m

$348

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Thu 3/26

2:52 am-10:11 am

2 stops7h 19m

Charlotte Douglas

Tue 4/7

9:00 pm-1:15 pm

1 stop16h 15m

$349

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

2:25 pm-12:24 am

1 stop9h 59m

Charleston

Mon 5/4

8:09 pm-9:20 am

1 stop13h 11m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 45 results
1
2
3
...
5

Best time to book a flight from Santo Domingo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to South Carolina

How much does it cost to fly round-trip from Santo Domingo to South Carolina?

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to South Carolina?

    Santo Domingo Las Americas (SDQ) is the airport you will fly out of if you book a flight from Santo Domingo to South Carolina. It is only a 17.5 mi journey to Las Americas (SDQ) from Santo Domingo’s city center.

  • How long is the flight from Santo Domingo to South Carolina?

    Spirit Airlines, Delta, and American Airlines can get you from Santo Domingo to South Carolina in just under 8h 11m. Your travel time can differ by up to 2h 07m. The distance between Santo Domingo and South Carolina is about 1187 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santo Domingo to South Carolina?

    While some choose either Santo Domingo Las Americas - Charleston or Santo Domingo Las Americas - Columbia Metropolitan, Santo Domingo Las Americas - Charlotte Douglas is the most popular route from Santo Domingo to South Carolina.

  • Can I find deals for flights from Santo Domingo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to South Carolina.

  • Can I find deals for business class flights from Santo Domingo to South Carolina?

    Yes. Cheapflights offers flight deals from Santo Domingo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to John F Kennedy Intl flights
Santo Domingo to Newark flights
Santiago de los Caballeros to John F Kennedy Intl flights
Santiago de los Caballeros to Newark flights
Santo Domingo to Orlando flights
Santo Domingo to Miami flights
Santo Domingo to LaGuardia flights
Santo Domingo to Fort Lauderdale flights
Santo Domingo to Boston flights
Santiago de los Caballeros to LaGuardia flights
Punta Cana to John F Kennedy Intl flights
Punta Cana to O'Hare Intl flights
Santiago de los Caballeros to Orlando flights
Santo Domingo to Atlanta flights
Punta Cana to Atlanta flights
Punta Cana to Newark flights
Santo Domingo to Philadelphia flights
Santiago de los Caballeros to Boston flights
Santiago de los Caballeros to Miami flights
Punta Cana to Miami flights
Santo Domingo to Dallas/Fort Worth flights
Santiago de los Caballeros to Fort Lauderdale flights
Santo Domingo to Las Vegas flights
Punta Cana to Fort Lauderdale flights
Punta Cana to Dulles Intl flights
Santo Domingo to Tampa flights
Punta Cana to Orlando flights
Puerto Plata to John F Kennedy Intl flights
Punta Cana to LaGuardia flights
Punta Cana to Baltimore flights
Santo Domingo to O'Hare Intl flights
Santo Domingo to Charlotte flights
Santo Domingo to Hobby flights
Santo Domingo to Los Angeles flights
Santo Domingo to Dulles Intl flights
Punta Cana to Hobby flights
Punta Cana to Philadelphia flights
Punta Cana to Boston flights
Santo Domingo to Baltimore flights
Punta Cana to George Bush Intcntl flights
Puerto Plata to Newark flights
Santo Domingo to Raleigh flights
Santo Domingo to George Bush Intcntl flights
Santo Domingo to San Francisco flights
Punta Cana to Reagan-National flights
Punta Cana to Tampa flights
Santo Domingo to New Orleans flights
Santo Domingo to West Palm Beach flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.