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$148+ Cheap flights from Santo Domingo (SDQ) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — CHS
Mar 9 — Mar 161
Mon 3/9
Mon 3/16
1 adult, Economy
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Cheap flight deals from Santo Domingo to South Carolina

Cheapest flights from Santo Domingo to South Carolina
Explore the most affordable flight options available from Santo Domingo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 7, 2026.

This CheapOair deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/193:37 pm
SDQ
-
CLT
1 stop9h 03m
Spirit Airlines
Tue 5/196:00 am
CLT
-
SDQ
1 stop8h 32m
Spirit Airlines
Deal found 2/6$277
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1912:31 pm
SDQ
-
CLT
1 stop20h 27m
Multiple Airlines
Thu 2/2611:00 am
CLT
-
SDQ
1 stop26h 20m
Multiple Airlines
Deal found 2/7$300
This CheapOair deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/262:20 pm
SDQ
-
CLT
1 stop10h 18m
Spirit Airlines
Thu 4/99:00 pm
CLT
-
SDQ
1 stop16h 15m
Spirit Airlines
Deal found 2/5$307
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/82:32 pm
SDQ
-
CLT
1 stop17h 54m
Multiple Airlines
Sun 3/228:56 am
CLT
-
SDQ
1 stop16h 42m
Multiple Airlines
Deal found 2/7$310
This OneTravel deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure OneTravel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/122:20 pm
SDQ
-
CLT
1 stop5h 57m
Spirit Airlines
Thu 3/199:00 pm
CLT
-
SDQ
1 stop16h 15m
Spirit Airlines
Deal found 2/7$311
This Cheapflightsfares deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/302:52 am
SDQ
-
CLT
1 stop17h 25m
Spirit Airlines
Tue 4/76:00 am
CLT
-
SDQ
1 stop7h 15m
Spirit Airlines
Deal found 2/6$312
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/193:37 pm
SDQ
-
CLT
1 stop22h 41m
Multiple Airlines
Tue 5/53:16 pm
CLT
-
SDQ
2 stops25h 13m
Multiple Airlines
Deal found 2/6$314
This Kiwi.com deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/63:32 pm
SDQ
-
CLT
1 stop6h 26m
Multiple Airlines
Sun 2/86:00 am
CLT
-
SDQ
1 stop7h 27m
Multiple Airlines
Deal found 2/5$317
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/252:52 am
SDQ
-
CLT
1 stop11h 25m
Multiple Airlines
Sun 4/59:00 pm
CLT
-
SDQ
1 stop28h 38m
Multiple Airlines
Deal found 2/6$319
This Cheapflightsfares deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/302:52 am
SDQ
-
CLT
1 stop17h 25m
Spirit Airlines
Mon 4/61:20 pm
CLT
-
SDQ
1 stop12h 18m
Spirit Airlines
Deal found 2/5$320
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:19 am
SDQ
-
CLT
1 stop25h 48m
Multiple Airlines
Mon 3/3010:52 pm
CLT
-
SDQ
2 stops41h 37m
Multiple Airlines
Deal found 2/6$322
This Mytrip deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:37 pm
SDQ
-
CLT
1 stop9h 03m
Spirit Airlines
Tue 5/57:18 pm
CLT
-
SDQ
2 stops19h 14m
Spirit Airlines
Deal found 2/4$326

Find flight deals from Santo Domingo to South Carolina

Keep the following information in mind while searching for Santo Domingo to South Carolina flight deals. Data was last updated February 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$277
(CheapOair)

One-way from

$148
(Cheapflightsfares)
Provider with most accurate pricing for Santo Domingo Las Americas-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Myrtle Beach Intl flights.
Search Deals
From Santo Domingo Las Americas to South Carolina
Search Deals
One-way flight from Santo Domingo Las Americas to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 7, 2026.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Santo Domingo

Fly to

South Carolina

Route

Depart

Return

Price

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Thu 3/26

2:52 am-8:17 pm

1 stop17h 25m

Charlotte Douglas

Tue 4/7

1:20 pm-1:38 am

1 stop12h 18m

$307

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Sun 4/19

3:37 pm-2:18 pm

1 stop22h 41m

Charlotte Douglas

Sun 4/26

2:28 pm-4:29 pm

1 stop26h 01m

$307

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Thu 3/26

2:20 pm-12:38 am

1 stop10h 18m

Charlotte Douglas

Thu 4/9

9:00 pm-1:15 pm

1 stop16h 15m

$307

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Tue 4/28

3:37 pm-12:40 am

1 stop9h 03m

Charlotte Douglas

Tue 5/5

8:55 am-2:32 pm

1 stop5h 37m

$311

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Sun 3/22

2:52 am-12:38 am

1 stop21h 46m

Charlotte Douglas

Mon 3/30

8:56 am-1:38 am

1 stop16h 42m

$312

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Wed 2/18

3:32 pm-11:56 pm

1 stop9h 24m

Charlotte Douglas

Mon 3/2

5:55 am-2:20 pm

1 stop7h 25m

$312

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Sun 4/19

3:37 pm-2:18 pm

1 stop22h 41m

Charlotte Douglas

Tue 5/5

3:16 pm-4:29 pm

2 stops25h 13m

$314

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Wed 3/25

2:52 am-2:17 pm

1 stop11h 25m

Charlotte Douglas

Sun 4/5

9:00 pm-1:38 am

1 stop28h 38m

$319

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Mon 3/30

2:52 am-8:17 pm

1 stop17h 25m

Charlotte Douglas

Mon 4/6

1:20 pm-1:38 am

1 stop12h 18m

$320

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Wed 2/25

3:32 pm-11:56 pm

1 stop9h 24m

Charlotte Douglas

Wed 3/4

5:55 am-2:20 pm

1 stop7h 25m

$320

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/5

Showing 1-10 of 39 results
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Best time to book a flight from Santo Domingo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to South Carolina?

    Santo Domingo Las Americas (SDQ) is the airport you will fly out of if you book a flight from Santo Domingo to South Carolina. It is only a 17.5 mi journey to Las Americas (SDQ) from Santo Domingo’s city center.

  • How long is the flight from Santo Domingo to South Carolina?

    Spirit Airlines, JetBlue, and American Airlines can get you from Santo Domingo to South Carolina in just under 8h 35m. Your travel time can differ by up to 8h 04m. The distance between Santo Domingo and South Carolina is about 1187 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santo Domingo to South Carolina?

    While some choose either Santo Domingo Las Americas - Charleston or Santo Domingo Las Americas - Columbia Metropolitan, Santo Domingo Las Americas - Charlotte Douglas is the most popular route from Santo Domingo to South Carolina.

  • Can I find deals for flights from Santo Domingo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to South Carolina.

  • Can I find deals for business class flights from Santo Domingo to South Carolina?

    Yes. Cheapflights offers flight deals from Santo Domingo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Santo Domingo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Punta Cana to LaGuardia flights
Santo Domingo to Raleigh flights
Santo Domingo to Charlotte flights
Santo Domingo to Los Angeles flights
Punta Cana to Baltimore flights
Punta Cana to Orlando flights
Punta Cana to Midway flights
Punta Cana to Charlotte flights
Santo Domingo to Denver flights
Punta Cana to Los Angeles flights
Santo Domingo to George Bush Intcntl flights
Santiago de los Caballeros to Philadelphia flights

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