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$163+ Cheap flights from Santo Domingo (SDQ) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — CHS
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
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Cheap flight deals from Santo Domingo to South Carolina

Keep the following information in mind while searching for Santo Domingo to South Carolina flight deals. Data was last updated October 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$326
(Kiwi.com)

One-way from

$163
(Mytrip)
Provider with most accurate pricing for Santo Domingo Las Americas-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Myrtle Beach Intl flights.
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From Santo Domingo Las Americas to South Carolina
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One-way flight from Santo Domingo Las Americas to South Carolina
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Find flight deals from Santo Domingo to South Carolina

Cheapest flights from Santo Domingo to South Carolina
Explore the most affordable flight options available from Santo Domingo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:05 amSDQ - CHS
1 stop14h 55mDelta
Fri 11/712:50 pmCHS - SDQ
1 stop11h 37mDelta
Deal found 10/13$319
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/274:35 pmSDQ - CHS
1 stop6h 30mSpirit Airlines
Thu 12/410:40 amCHS - SDQ
1 stop27h 53mSpirit Airlines
Deal found 10/13$326
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:14 pmSDQ - CHS
1 stop6h 45mAmerican Airlines
Mon 11/107:57 pmCHS - SDQ
1 stop15h 22mAmerican Airlines
Deal found 10/12$339
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:24 pmSDQ - CHS
1 stop15h 18mAmerican Airlines
Sun 11/166:00 amCHS - SDQ
1 stop10h 24mAmerican Airlines
Deal found 10/12$345
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/274:35 pmSDQ - CHS
1 stop6h 30mMultiple Airlines
Thu 12/48:53 pmCHS - SDQ
2 stops41h 40mMultiple Airlines
Deal found 10/13$357
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/74:25 pmSDQ - CLT
1 stop17h 37mMultiple Airlines
Mon 11/1010:42 pmCLT - SDQ
1 stop22h 03mMultiple Airlines
Deal found 10/13$364
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/193:35 pmSDQ - CLT
1 stop21h 21mMultiple Airlines
Mon 10/277:29 pmCLT - SDQ
1 stop26h 16mMultiple Airlines
Deal found 10/13$368
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1010:19 amSDQ - CLT
1 stop27h 41mMultiple Airlines
Tue 11/253:01 pmCLT - SDQ
1 stop24h 28mMultiple Airlines
Deal found 10/14$376
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2610:19 amSDQ - CLT
1 stop23h 30mMultiple Airlines
Thu 12/41:57 pmCLT - SDQ
1 stop6h 48mMultiple Airlines
Deal found 10/12$380
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:20 amSDQ - CHS
1 stop25h 17mMultiple Airlines
Tue 1/62:59 pmCHS - SDQ
1 stop11h 33mMultiple Airlines
Deal found 10/13$382
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/253:35 pmSDQ - CLT
1 stop18h 14mMultiple Airlines
Mon 12/15:59 pmCLT - SDQ
1 stop20h 31mMultiple Airlines
Deal found 10/12$425
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/113:35 pmSDQ - CLT
1 stop22h 25mMultiple Airlines
Thu 11/208:52 pmCLT - SDQ
2 stops14h 33mMultiple Airlines
Deal found 10/12$453

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Santo Domingo

Fly to

South Carolina

Route

Depart

Return

Price

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 11/27

4:35 pm-10:05 pm

1 stop6h 30m

Charleston

Thu 12/4

10:40 am-3:33 pm

1 stop27h 53m

$326

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 2/5

7:05 am-4:47 pm

1 stop10h 42m

Charleston

Sat 2/7

12:45 pm-11:59 pm

1 stop10h 14m

$339

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Sat 11/8

4:45 pm-8:29 am

2 stops16h 44m

Charleston

Mon 11/10

7:57 pm-12:19 pm

1 stop15h 22m

$344

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Sun 11/9

6:24 pm-8:42 am

1 stop15h 18m

Charleston

Sun 11/16

6:00 am-5:24 pm

1 stop10h 24m

$345

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 11/27

4:35 pm-10:05 pm

1 stop6h 30m

Charleston

Thu 12/4

8:53 pm-3:33 pm

2 stops41h 40m

$357

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Fri 1/23

8:01 am-2:48 pm

1 stop7h 47m

Charlotte Douglas

Sun 2/1

5:45 am-1:39 am

2 stops18h 54m

$372

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Wed 1/21

8:01 am-9:06 pm

1 stop14h 05m

Charlotte Douglas

Sun 1/25

5:45 am-1:39 am

2 stops18h 54m

$372

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Mon 11/10

10:19 am-1:00 pm

1 stop27h 41m

Charlotte Douglas

Tue 11/25

3:01 pm-4:29 pm

1 stop24h 28m

$376

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Mon 12/22

8:20 am-8:37 am

1 stop25h 17m

Charleston

Tue 1/6

2:59 pm-3:32 am

1 stop11h 33m

$382

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Thu 2/5

8:01 am-12:59 am

2 stops17h 58m

Charlotte Douglas

Sat 2/21

5:45 am-1:39 am

2 stops18h 54m

$404

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/13

Showing 1-10 of 25 results
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Best time to book a flight from Santo Domingo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to South Carolina

What is the cheapest time of day to fly from SDQ to SC?

Find hourly flight availability from Santo Domingo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 14, 2025.

When flying from Santo Domingo to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 44% versus a flight in the morning.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 14, 2025.
Peruse reviews from past customers who have flown with Delta from Santo Domingo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,975 reviews

Overall

8.0

Crew

8.5

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,975 reviews
Delta
8.0
Very good
7,975 reviews

Overall

8.0

Crew

8.5

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to South Carolina?

    Santo Domingo Las Americas (SDQ) is the airport you will fly out of if you book a flight from Santo Domingo to South Carolina. It is only a 17.5 mi journey to Las Americas (SDQ) from Santo Domingo’s city center.

  • How long is the flight from Santo Domingo to South Carolina?

    Spirit Airlines, Delta, and American Airlines can get you from Santo Domingo to South Carolina in just under 6h 30m. Your travel time can differ by up to 10h 14m. The distance between Santo Domingo and South Carolina is about 1187 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Santo Domingo to South Carolina one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $163. Delta flights start at $177 while deals on JetBlue start at $218 one-way.

  • What are the most popular routes from Santo Domingo to South Carolina?

    While some choose either Santo Domingo Las Americas - Charleston or Santo Domingo Las Americas - Columbia Metropolitan, Santo Domingo Las Americas - Charlotte Douglas is the most popular route from Santo Domingo to South Carolina.

  • Can I find deals for flights from Santo Domingo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to South Carolina.

  • Can I find deals for business class flights from Santo Domingo to South Carolina?

    Yes. Cheapflights offers flight deals from Santo Domingo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Santo Domingo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Santo Domingo to South Carolina

Discover the top airline that operate flights from Santo Domingo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$494Average$494FlexibilityNo cancel feeOn-timeN/A

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