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$328+ Cheap flights from Madrid, Spain (MAD) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — CHS
Feb 5 — Feb 121
Thu 2/5
Thu 2/12
1 adult, Economy
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Cheap flight deals from Madrid to South Carolina

Keep the following information in mind while searching for Madrid to South Carolina flight deals. Data was last updated January 6, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$485
(Trip.com)

One-way from

$328
(Kiwi.com)
Provider with most accurate pricing for Madrid Barajas-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Madrid Barajas-Myrtle Beach Intl flights.
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From Madrid Barajas to South Carolina
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One-way flight from Madrid Barajas to South Carolina
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Find flight deals from Madrid to South Carolina

Cheapest flights from Madrid to South Carolina
Explore the most affordable flight options available from Madrid to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

This Trip.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1010:20 amMAD - CLT
2 stops19h 39mMultiple Airlines
Tue 2/249:21 amCLT - MAD
2 stops18h 09mMultiple Airlines
Deal found 1/4$485
This Trip.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1010:20 amMAD - CLT
2 stops19h 39mMultiple Airlines
Wed 2/189:21 amCLT - MAD
2 stops18h 09mMultiple Airlines
Deal found 1/5$493
This Trip.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/227:40 amMAD - CLT
2 stops22h 19mMultiple Airlines
Wed 2/43:15 pmCLT - MAD
2 stops23h 05mMultiple Airlines
Deal found 1/4$513
This Trip.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/57:40 amMAD - CLT
2 stops22h 19mMultiple Airlines
Mon 2/239:21 amCLT - MAD
2 stops22h 44mMultiple Airlines
Deal found 1/4$522
This Trip.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1910:20 amMAD - CLT
2 stops19h 39mMultiple Airlines
Thu 2/269:21 amCLT - MAD
2 stops32h 09mMultiple Airlines
Deal found 1/5$528
This Mytrip deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/222:55 pmMAD - SAV
2 stops27h 27mMultiple Airlines
Mon 1/261:17 pmSAV - MAD
2 stops14h 13mMultiple Airlines
Deal found 1/6$533
This Mytrip deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/189:10 pmMAD - CLT
2 stops32h 49mMultiple Airlines
Wed 2/259:21 amCLT - MAD
2 stops18h 09mMultiple Airlines
Deal found 1/4$551
This Mytrip deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/86:35 pmMAD - CLT
3 stops34h 24mMultiple Airlines
Wed 3/189:21 amCLT - MAD
2 stops25h 49mMultiple Airlines
Deal found 1/5$574
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/312:40 pmMAD - GSP
1 stop12h 27mAmerican Airlines
Tue 2/106:00 amGSP - MAD
1 stop20h 55mAmerican Airlines
Deal found 1/6$624
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1512:40 pmMAD - CHS
1 stop16h 27mAmerican Airlines
Mon 1/1912:29 pmCHS - MAD
1 stop11h 16mAmerican Airlines
Deal found 1/6$624
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/312:40 pmMAD - SAV
1 stop14h 20mAmerican Airlines
Tue 2/107:10 pmSAV - MAD
2 stops31h 40mAmerican Airlines
Deal found 1/6$624
This Mytrip deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2112:10 pmMAD - SAV
3 stops30h 12mMultiple Airlines
Sun 1/251:17 pmSAV - MAD
2 stops21h 53mMultiple Airlines
Deal found 1/5$629

Cheapflights Fare Finder

 
Customize your flight search to find flights from Madrid to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 6, 2026.
Use the filters below to find and compare flights from Madrid to South Carolina that are best for you.

Fly from

Madrid

Fly to

South Carolina

Route

Depart

Return

Price

MadridSavannah

MAD - SAV

MADSAV

Madrid Barajas

Thu 1/22

2:55 pm-12:22 pm

2 stops27h 27m

Savannah/Hilton Head

Mon 1/26

1:17 pm-8:20 pm

3 stops25h 03m

$556

MadridGreenville

MAD - GSP

MADGSP

Madrid Barajas

Tue 2/3

12:40 pm-7:07 pm

1 stop12h 27m

Greenville

Tue 2/10

6:00 am-8:55 am

1 stop20h 55m

$624

MadridSavannah

MAD - SAV

MADSAV

Madrid Barajas

Thu 1/22

11:00 am-11:16 pm

2 stops18h 16m

Savannah/Hilton Head

Mon 1/26

10:22 am-5:45 am

1 stop13h 23m

$624

MadridSavannah

MAD - SAV

MADSAV

Madrid Barajas

Tue 2/3

12:40 pm-9:00 pm

1 stop14h 20m

Savannah/Hilton Head

Tue 2/10

7:10 pm-8:50 am

2 stops31h 40m

$624

MadridSavannah

MAD - SAV

MADSAV

Madrid Barajas

Wed 1/21

12:10 pm-12:22 pm

3 stops30h 12m

Savannah/Hilton Head

Sun 1/25

1:17 pm-5:10 pm

2 stops21h 53m

$629

MadridSavannah

MAD - SAV

MADSAV

Madrid Barajas

Wed 1/21

12:40 pm-10:38 pm

1 stop15h 58m

Savannah/Hilton Head

Sun 1/25

11:33 am-5:50 am

1 stop12h 17m

$642

MadridGreenville

MAD - GSP

MADGSP

Madrid Barajas

Wed 1/21

10:00 am-6:26 pm

1 stop14h 26m

Greenville

Sun 1/25

1:45 pm-8:55 am

2 stops13h 10m

$643

MadridCharlotte

MAD - CLT

MADCLT

Madrid Barajas

Sun 2/1

12:50 pm-9:10 pm

1 stop14h 20m

Charlotte Douglas

Wed 2/11

4:10 pm-5:45 am

Nonstop7h 35m

$643

MadridCharlotte

MAD - CLT

MADCLT

Madrid Barajas

Sun 1/25

1:15 pm-8:04 pm

1 stop12h 49m

Charlotte Douglas

Tue 2/10

2:11 pm-8:55 am

1 stop12h 44m

$643

MadridCharleston

MAD - CHS

MADCHS

Madrid Barajas

Fri 2/13

1:00 pm-11:01 pm

1 stop16h 01m

Charleston

Sat 2/28

12:25 pm-8:50 am

1 stop14h 25m

$659

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/3

Showing 1-10 of 60 results
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Best time to book a flight from Madrid to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Madrid with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to South Carolina

What is the cheapest month to book a flight from Madrid to South Carolina?

Currently, June is the cheapest month in which you can book a flight from Madrid to South Carolina (average of $673). Flying from Madrid to South Carolina in July is currently the most expensive (average of $923). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Madrid to South Carolina?

Related info for your journey

Find useful and relevant information for your journey from Madrid to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Madrid to South Carolina?

    Madrid Barajas (MAD) is the airport you will fly out of if you book a flight from Madrid to South Carolina. It is only a 8.5 mi journey to Barajas (MAD) from Madrid’s city center.

  • How long is the flight from Madrid to South Carolina?

    A quick flight from Madrid to South Carolina can take about 12h 27m. American Airlines provides one of the quickest options available for as low as $624. Madrid and South Carolina are separated by a distance of 4169 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Madrid to South Carolina?

    When deciding which route to take from Madrid to South Carolina consider Madrid Barajas - Charlotte Douglas, Madrid Barajas - Charleston or Madrid Barajas - Greenville as they are the most popular.

  • Can I find deals for flights from Madrid to South Carolina that include hotel bookings?

    Yes. In addition to deals on Madrid to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Madrid to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to South Carolina.

  • Can I find deals for business class flights from Madrid to South Carolina?

    Yes. Cheapflights offers flight deals from Madrid to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to South Carolina?

    Currently, June is the cheapest month in which you can book a flight from Madrid to South Carolina (average of $673). Flying from Madrid to South Carolina in July is currently the most expensive (average of $923). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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