HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$325+ Cheap flights from Madrid, Spain (MAD) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — CHS
Dec 22 — Dec 291
Mon 12/22
Mon 12/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Madrid to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Madrid to South Carolina

Keep the following information in mind while searching for Madrid to South Carolina flight deals. Data was last updated November 22, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$530
(Mytrip)

One-way from

$325
(Kiwi.com)
Provider with most accurate pricing for Madrid Barajas-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Madrid Barajas-Myrtle Beach Intl flights.
Search Deals
From Madrid Barajas to South Carolina
Search Deals
One-way flight from Madrid Barajas to South Carolina
Search Deals

Find flight deals from Madrid to South Carolina

Cheapest flights from Madrid to South Carolina
Explore the most affordable flight options available from Madrid to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 22, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:35 pmMAD - CHS
1 stop25h 25mMultiple Airlines
Sun 12/1411:55 amCHS - MAD
2 stops38h 45mMultiple Airlines
Deal found 11/20$604
This Mytrip deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:20 amMAD - CHS
3 stops30h 40mMultiple Airlines
Mon 12/811:55 amCHS - MAD
3 stops29h 35mMultiple Airlines
Deal found 11/20$618
This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:35 pmMAD - CLT
2 stops50h 57mUnited Airlines
Sun 12/75:05 pmCLT - MAD
2 stops38h 10mUnited Airlines
Deal found 11/20$648
This Mytrip deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1112:10 pmMAD - CHS
2 stops28h 50mMultiple Airlines
Sun 12/1411:55 amCHS - MAD
3 stops26h 25mMultiple Airlines
Deal found 11/22$763
This Mytrip deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1710:20 amMAD - CLT
2 stops30h 43mMultiple Airlines
Sat 1/109:07 pmCLT - MAD
3 stops21h 08mMultiple Airlines
Deal found 11/19$774
This United Airlines deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:00 amMAD - CHS
2 stops43h 30mUnited Airlines
Sun 12/146:05 amCHS - MAD
2 stops20h 00mUnited Airlines
Deal found 11/21$790
This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:35 amMAD - CHS
2 stops16h 26mUnited Airlines
Sun 12/146:05 amCHS - MAD
2 stops20h 00mUnited Airlines
Deal found 11/20$792
This Cheapflightsfares deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/101:00 pmMAD - CLT
Nonstop9h 25mIberia
Thu 2/56:30 pmCLT - MAD
1 stop12h 10mIberia
Deal found 11/21$797
This lol.travel deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:15 amMAD - CHS
1 stop12h 57mLufthansa
Mon 12/87:47 pmCHS - MAD
1 stop30h 18mLufthansa
Deal found 11/20$797
This British Airways deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/101:00 pmMAD - CLT
Nonstop9h 25mBritish Airways
Thu 2/56:30 pmCLT - MAD
1 stop12h 10mBritish Airways
Deal found 11/20$802
This Delta deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1011:00 amMAD - CLT
2 stops16h 55mDelta
Thu 2/52:25 pmCLT - MAD
2 stops18h 55mDelta
Deal found 11/21$808
This Cheapflightsfares deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:55 amMAD - CLT
2 stops18h 55mLufthansa
Thu 2/56:50 pmCLT - MAD
1 stop17h 00mLufthansa
Deal found 11/20$812

Cheapflights Fare Finder

 
Customize your flight search to find flights from Madrid to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 22, 2025.
Use the filters below to find and compare flights from Madrid to South Carolina that are best for you.

Fly from

Madrid

Fly to

South Carolina

Route

Depart

Return

Price

MadridCharleston

MAD - CHS

MADCHS

Madrid Barajas

Fri 12/12

3:35 pm-11:00 am

1 stop25h 25m

Charleston

Sun 12/14

11:55 am-8:40 am

2 stops38h 45m

$604

MadridCharlotte

MAD - CLT

MADCLT

Madrid Barajas

Thu 1/15

9:10 pm-11:59 pm

2 stops32h 49m

Charlotte Douglas

Wed 1/28

7:00 am-11:30 pm

3 stops34h 30m

$616

MadridCharleston

MAD - CHS

MADCHS

Madrid Barajas

Thu 12/4

10:20 am-11:00 am

3 stops30h 40m

Charleston

Mon 12/8

11:55 am-11:30 pm

3 stops29h 35m

$618

MadridCharleston

MAD - CHS

MADCHS

Madrid Barajas

Mon 1/12

6:10 am-8:38 am

2 stops32h 28m

Charleston

Sun 1/18

5:05 pm-8:00 am

1 stop32h 55m

$724

MadridGreenville

MAD - GSP

MADGSP

Madrid Barajas

Tue 2/3

6:00 am-4:19 pm

2 stops16h 19m

Greenville

Tue 2/10

6:45 pm-3:20 pm

2 stops14h 35m

$739

MadridGreenville

MAD - GSP

MADGSP

Madrid Barajas

Tue 2/3

1:15 pm-11:36 pm

2 stops16h 21m

Greenville

Tue 2/10

6:25 am-9:25 am

1 stop21h 00m

$750

MadridSavannah

MAD - SAV

MADSAV

Madrid Barajas

Wed 1/21

8:30 am-10:46 pm

2 stops20h 16m

Savannah/Hilton Head

Sun 1/25

1:51 pm-9:15 am

1 stop13h 24m

$756

MadridGreenville

MAD - GSP

MADGSP

Madrid Barajas

Fri 2/20

6:00 am-11:59 pm

2 stops23h 59m

Greenville

Tue 2/24

12:05 pm-9:15 am

1 stop15h 10m

$757

MadridGreenville

MAD - GSP

MADGSP

Madrid Barajas

Tue 2/3

1:35 pm-2:19 pm

3 stops30h 44m

Greenville

Tue 2/10

5:34 pm-8:00 am

3 stops32h 26m

$760

MadridCharleston

MAD - CHS

MADCHS

Madrid Barajas

Thu 12/11

12:10 pm-11:00 am

2 stops28h 50m

Charleston

Sun 12/14

11:55 am-8:20 pm

3 stops26h 25m

$763

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/21

Showing 1-10 of 53 results
1
2
3
...
6

Best time to book a flight from Madrid to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Madrid with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to South Carolina

What is the cheapest month to book a flight from Madrid to South Carolina?

Currently, January is the cheapest month in which you can book a flight from Madrid to South Carolina (average of $579). Flying from Madrid to South Carolina in July is currently the most expensive (average of $923). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Madrid to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Madrid to South Carolina?

    Madrid Barajas (MAD) is the airport you will fly out of if you book a flight from Madrid to South Carolina. It is only a 8.5 mi journey to Barajas (MAD) from Madrid’s city center.

  • How long is the flight from Madrid to South Carolina?

    A quick flight from Madrid to South Carolina can take about 16h 21m. American Airlines provides one of the quickest options available for as low as $750. Madrid and South Carolina are separated by a distance of 4169 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Madrid to South Carolina one-way?

    $519 is the cheapest one-way deal found within the past few days, from Finnair. You may also be able to find cheap deals on British Airways and American Airlines, with prices starting from $521 and $530, respectively.

  • What are the most popular routes from Madrid to South Carolina?

    When deciding which route to take from Madrid to South Carolina consider Madrid Barajas - Charlotte Douglas, Madrid Barajas - Charleston or Madrid Barajas - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Madrid to South Carolina that include hotel bookings?

    Yes. In addition to deals on Madrid to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Madrid to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to South Carolina.

  • Can I find deals for business class flights from Madrid to South Carolina?

    Yes. Cheapflights offers flight deals from Madrid to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Madrid to South Carolina (average of $579). Flying from Madrid to South Carolina in July is currently the most expensive (average of $923). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Madrid to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Madrid to John F Kennedy Intl flights
Madrid to Newark flights
Madrid to Miami flights
Madrid to LaGuardia flights
Madrid to Fort Lauderdale flights
Madrid to Los Angeles flights
Madrid to O'Hare Intl flights
Madrid to Boston flights
Madrid to Dulles Intl flights
Madrid to Dallas/Fort Worth flights
Madrid to West Palm Beach flights
Madrid to Orlando flights
Madrid to Las Vegas flights
Madrid to Baltimore flights
Madrid to Midway flights
Madrid to Charlotte flights
Madrid to Philadelphia flights
Madrid to San Francisco flights
Madrid to Atlanta flights
Madrid to Reagan-National flights
Madrid to Hobby flights
Madrid to Seattle flights
Madrid to Ontario flights
Madrid to Love Field flights
Madrid to Denver flights
Madrid to George Bush Intcntl flights
Madrid to San Diego flights
Madrid to Santa Ana flights
Madrid to Austin flights
Madrid to Sky Harbor Intl flights
Madrid to Minneapolis flights
Madrid to Tampa flights
Madrid to Portland flights
Madrid to San Jose flights
Madrid to Honolulu flights
Madrid to Burbank flights
Madrid to Salt Lake City flights
Madrid to Jacksonville flights
Madrid to Raleigh flights
Madrid to Norfolk flights
Madrid to Pittsburgh flights
Madrid to Detroit flights
Madrid to San Antonio flights
Madrid to Nashville flights
Madrid to New Orleans flights
Madrid to Richmond flights
Madrid to Oakland flights
Madrid to Columbus flights
Madrid to Anchorage flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.