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South Carolina

$194+ Cheap flights from Gainesville (GNV) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
GNV — CHS
oct. 29 — nov. 51
mer. 10/29
mer. 11/5
1 adult, Economy
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Cheap flight deals from Gainesville to South Carolina

Keep the following information in mind while searching for Gainesville to South Carolina flight deals. Data was last updated septembre 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$215
(American Airlines)

One-way from

$194
(Delta)
Provider with most accurate pricing for Gainesville Regional-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Gainesville Regional-Myrtle Beach Intl flights.
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From Gainesville Regional to South Carolina
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One-way flight from Gainesville Regional to South Carolina
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Find flight deals from Gainesville to South Carolina

Cheapest flights from Gainesville to South Carolina
Explore the most affordable flight options available from Gainesville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septembre 29, 2025.

This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/46:28 amGNV - CLT
Nonstop1h 44mAmerican Airlines
mar. 11/118:41 amCLT - GNV
Nonstop1h 45mAmerican Airlines
Deal found 9/27$215
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/286:58 pmGNV - CLT
Nonstop1h 44mAmerican Airlines
mar. 11/48:41 amCLT - GNV
Nonstop1h 45mAmerican Airlines
Deal found 9/28$220
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 10/226:58 pmGNV - CLT
Nonstop1h 44mAmerican Airlines
mer. 10/298:25 amCLT - GNV
Nonstop1h 44mAmerican Airlines
Deal found 9/29$225
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 11/14:46 pmGNV - CLT
Nonstop1h 45mAmerican Airlines
mer. 11/59:40 pmCLT - GNV
Nonstop1h 45mAmerican Airlines
Deal found 9/27$251
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 10/177:44 pmGNV - CLT
Nonstop1h 45mAmerican Airlines
lun. 10/2010:31 pmCLT - GNV
Nonstop1h 46mAmerican Airlines
Deal found 9/27$260
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 10/166:00 amGNV - CLT
1 stop4h 30mAmerican Airlines
lun. 10/207:10 amCLT - GNV
Nonstop1h 43mAmerican Airlines
Deal found 9/27$270
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 11/146:45 pmGNV - CLT
Nonstop1h 49mAmerican Airlines
dim. 11/168:40 pmCLT - GNV
Nonstop1h 46mAmerican Airlines
Deal found 9/28$275
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 10/177:07 pmGNV - CLT
1 stop4h 43mDelta
dim. 10/195:30 amCLT - GNV
1 stop3h 56mDelta
Deal found 9/28$280
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 10/255:57 pmGNV - GSP
1 stop4h 21mDelta
sam. 11/19:45 amGSP - GNV
1 stop3h 02mDelta
Deal found 9/27$337
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 10/254:46 pmGNV - GSP
1 stop4h 25mAmerican Airlines
sam. 11/12:37 pmGSP - GNV
2 stops9h 18mAmerican Airlines
Deal found 9/27$367
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 10/116:04 amGNV - GSP
1 stop2h 55mDelta
mar. 10/1410:04 amGSP - GNV
1 stop4h 55mDelta
Deal found 9/27$387
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/141:32 pmGNV - MYR
1 stop4h 31mDelta
sam. 10/186:00 amMYR - GNV
1 stop3h 26mDelta
Deal found 9/29$387

Cheapflights Fare Finder

 
Customize your flight search to find flights from Gainesville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septembre 29, 2025.
Use the filters below to find and compare flights from Gainesville to South Carolina that are best for you.

Fly from

Gainesville

Fly to

South Carolina

Route

Depart

Return

Price

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

ven. 1/30

8:03 pm-9:50 pm

Nonstop1h 47m

Charlotte Douglas

dim. 2/1

10:30 pm-12:08 am

Nonstop1h 38m

$215

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

mar. 11/4

6:28 am-8:12 am

Nonstop1h 44m

Charlotte Douglas

mar. 11/11

8:41 am-10:26 am

Nonstop1h 45m

$215

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

mer. 10/22

6:58 pm-8:42 pm

Nonstop1h 44m

Charlotte Douglas

mer. 10/29

8:25 am-10:09 am

Nonstop1h 44m

$225

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

ven. 1/30

1:10 pm-6:20 pm

1 stop5h 10m

Charlotte Douglas

dim. 2/1

5:30 am-9:26 am

1 stop3h 56m

$235

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

mar. 10/28

1:32 pm-4:40 pm

1 stop3h 08m

Charlotte Douglas

mar. 11/4

5:30 am-9:26 am

1 stop3h 56m

$235

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

ven. 11/14

6:00 am-10:42 am

1 stop4h 42m

Charlotte Douglas

dim. 11/16

8:40 pm-10:26 pm

Nonstop1h 46m

$235

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

mar. 10/28

6:00 am-10:30 am

1 stop4h 30m

Charlotte Douglas

mar. 11/4

8:41 am-10:26 am

Nonstop1h 45m

$240

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

sam. 10/25

5:57 pm-10:18 pm

1 stop4h 21m

Greenville

sam. 11/1

9:45 am-12:47 pm

1 stop3h 02m

$337

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

mar. 2/17

7:05 pm-11:36 pm

1 stop4h 31m

Greenville

lun. 2/23

5:45 am-9:26 am

1 stop3h 41m

$347

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

sam. 10/11

6:04 am-8:59 am

1 stop2h 55m

Greenville

mar. 10/14

10:04 am-2:59 pm

1 stop4h 55m

$387

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/28

Showing 1-10 of 50 results
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Best time to book a flight from Gainesville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Gainesville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Gainesville to South Carolina

What is the cheapest month to book a flight from Gainesville to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Gainesville to South Carolina (average of $217). Flying from Gainesville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GNV to SC?

Find hourly flight availability from Gainesville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septembre 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Gainesville to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated septembre 29, 2025.
Read through reviews of airlines operating flights from Gainesville to South Carolina, such as Delta. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,964 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,964 reviews
Delta
8.0
Very good
7,964 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Gainesville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Gainesville to South Carolina?

    If you book a flight to South Carolina from Gainesville, you will be flying from Gainesville Regional, which is the city’s only airport. Gainesville Regional (GNV) is located 4.2 mi from the center of Gainesville.

  • How long is the flight from Gainesville to South Carolina?

    Departing from Gainesville to South Carolina will take you 1h 47m. The distance between Gainesville and South Carolina is about 390 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Gainesville to South Carolina?

    Most travelers choose Gainesville Regional - Charlotte Douglas, Gainesville Regional - Myrtle Beach Intl or Gainesville Regional - Greenville when deciding on the best route from Gainesville to South Carolina.

  • Can I find deals for flights from Gainesville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Gainesville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Gainesville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Gainesville to South Carolina.

  • Can I find deals for business class flights from Gainesville to South Carolina?

    Yes. Cheapflights offers flight deals from Gainesville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Gainesville to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Gainesville to South Carolina (average of $217). Flying from Gainesville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Gainesville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Gainesville to South Carolina

Discover the top airline that operate flights from Gainesville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septembre 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$316Average$426FlexibilityNo cancel feeOn-timeN/A

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