HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$148+ Cheap flights from Gainesville (GNV) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
GNV — CHS
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Gainesville to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Gainesville to South Carolina

Keep the following information in mind while searching for Gainesville to South Carolina flight deals. Data was last updated August 14, 2025.

Round-trip from

$315
(American Airlines)

One-way from

$148
(Delta)
From Gainesville Regional to South Carolina
Search Deals
One-way flight from Gainesville Regional to South Carolina
Search Deals

Find flight deals from Gainesville to South Carolina

Cheapest flights from Gainesville to South Carolina
Explore the most affordable flight options available from Gainesville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/67:44 pmGNV - CLT
Nonstop1h 45mAmerican Airlines
Sat 10/117:10 amCLT - GNV
Nonstop1h 43mAmerican Airlines
Deal found 8/14$315
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/67:07 pmGNV - CLT
1 stop4h 43mDelta
Sat 10/115:05 pmCLT - GNV
1 stop5h 30mDelta
Deal found 8/14$325
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/194:43 pmGNV - CLT
Nonstop1h 50mAmerican Airlines
Sun 9/217:11 amCLT - GNV
Nonstop1h 39mAmerican Airlines
Deal found 8/13$335
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/36:00 amGNV - CLT
Nonstop1h 48mAmerican Airlines
Wed 9/172:25 pmCLT - GNV
Nonstop1h 43mAmerican Airlines
Deal found 8/12$352
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1910:10 amGNV - CLT
1 stop4h 43mDelta
Sun 9/218:25 amCLT - GNV
1 stop4h 06mDelta
Deal found 8/13$355
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2711:17 amGNV - MYR
1 stop4h 06mAmerican Airlines
Sun 8/319:19 amMYR - GNV
1 stop4h 11mAmerican Airlines
Deal found 8/12$367
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/66:13 amGNV - CLT
1 stop4h 17mAmerican Airlines
Sat 9/207:20 pmCLT - GNV
1 stop4h 39mAmerican Airlines
Deal found 8/11$372
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2210:11 amGNV - MYR
1 stop3h 39mDelta
Sun 10/266:00 amMYR - GNV
1 stop3h 26mDelta
Deal found 8/13$377
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:13 amGNV - CLT
1 stop4h 17mAmerican Airlines
Sun 9/147:11 amCLT - GNV
Nonstop1h 39mAmerican Airlines
Deal found 8/12$382
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/223:02 pmGNV - MYR
1 stop3h 43mAmerican Airlines
Sun 10/265:59 pmMYR - GNV
2 stops5h 56mAmerican Airlines
Deal found 8/13$392
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/66:13 amGNV - CLT
1 stop4h 17mAmerican Airlines
Fri 9/195:28 pmCLT - GNV
1 stop6h 31mAmerican Airlines
Deal found 8/11$392
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/192:55 pmGNV - CLT
Nonstop1h 42mAmerican Airlines
Tue 8/2610:00 pmCLT - GNV
Nonstop1h 38mAmerican Airlines
Deal found 8/12$409

Cheapflights Fare Finder

 
Customize your flight search to find flights from Gainesville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Gainesville to South Carolina that are best for you.

Fly from

Gainesville

Fly to

South Carolina

Route

Depart

Return

Price

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Wed 11/26

11:16 am-12:58 pm

Nonstop1h 42m

Charlotte Douglas

Fri 11/28

9:00 am-10:40 am

Nonstop1h 40m

$315

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Sat 9/27

6:45 pm-11:46 pm

1 stop5h 01m

Charlotte Douglas

Tue 9/30

5:30 am-9:25 am

1 stop3h 55m

$315

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Mon 10/6

7:44 pm-9:29 pm

Nonstop1h 45m

Charlotte Douglas

Sat 10/11

7:10 am-8:53 am

Nonstop1h 43m

$315

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Mon 10/6

7:44 pm-9:29 pm

Nonstop1h 45m

Charlotte Douglas

Wed 10/15

8:25 am-10:09 am

Nonstop1h 44m

$315

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Mon 10/6

7:07 pm-11:50 pm

1 stop4h 43m

Charlotte Douglas

Sat 10/11

5:05 pm-10:35 pm

1 stop5h 30m

$325

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Wed 11/26

7:05 pm-11:35 pm

1 stop4h 30m

Charlotte Douglas

Fri 11/28

6:00 am-10:08 am

1 stop4h 08m

$335

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Thu 9/25

9:15 am-10:59 am

Nonstop1h 44m

Charlotte Douglas

Sun 9/28

10:31 pm-12:13 am

Nonstop1h 42m

$335

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

Thu 2/5

8:03 pm-11:17 pm

1 stop3h 14m

Greenville

Sun 2/8

4:51 pm-12:04 am

1 stop7h 13m

$357

GainesvilleMyrtle Beach

GNV - MYR

GNVMYR

Gainesville Regional

Wed 8/27

11:17 am-3:23 pm

1 stop4h 06m

Myrtle Beach Intl

Sun 8/31

9:19 am-1:30 pm

1 stop4h 11m

$367

GainesvilleMyrtle Beach

GNV - MYR

GNVMYR

Gainesville Regional

Wed 10/22

10:11 am-1:50 pm

1 stop3h 39m

Myrtle Beach Intl

Sun 10/26

6:00 am-9:26 am

1 stop3h 26m

$377

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 23 results
1
2
3

Best time to book a flight from Gainesville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Gainesville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Gainesville to South Carolina

What is the cheapest month to book a flight from Gainesville to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Gainesville to South Carolina (average of $217). Flying from Gainesville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GNV to SC?

Find hourly flight availability from Gainesville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Gainesville to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 14, 2025.
Read through reviews of airlines operating flights from Gainesville to South Carolina, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Gainesville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Gainesville to South Carolina?

    If you book a flight to South Carolina from Gainesville, you will be flying from Gainesville Regional, which is the city’s only airport. Gainesville Regional (GNV) is located 4.2 mi from the center of Gainesville.

  • What are the most popular routes from Gainesville to South Carolina?

    Most travelers choose Gainesville Regional - Charlotte Douglas, Gainesville Regional - Myrtle Beach Intl or Gainesville Regional - Greenville when deciding on the best route from Gainesville to South Carolina.

  • Can I find deals for flights from Gainesville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Gainesville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Gainesville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Gainesville to South Carolina.

  • Can I find deals for business class flights from Gainesville to South Carolina?

    Yes. Cheapflights offers flight deals from Gainesville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Gainesville to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Gainesville to South Carolina (average of $217). Flying from Gainesville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Gainesville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to LaGuardia flights
Miami to LaGuardia flights
Fort Lauderdale to Newark flights
Fort Lauderdale to John F Kennedy Intl flights
Miami to Newark flights
Miami to John F Kennedy Intl flights
Orlando to John F Kennedy Intl flights
Tampa to John F Kennedy Intl flights
Orlando to LaGuardia flights
Tampa to Newark flights
Tampa to LaGuardia flights
Fort Lauderdale to Las Vegas flights
Orlando to Newark flights
Orlando to Las Vegas flights
West Palm Beach to John F Kennedy Intl flights
Tampa to Las Vegas flights
Orlando to Seattle flights
Orlando to Los Angeles flights
Tampa to Boston flights
Orlando to Dallas/Fort Worth flights
Orlando to O'Hare Intl flights
Tampa to Seattle flights
Fort Lauderdale to Atlanta flights
Tampa to Denver flights
Tampa to Dulles Intl flights
Fort Lauderdale to Los Angeles flights
Fort Lauderdale to Dallas/Fort Worth flights
Miami to Los Angeles flights
Miami to Las Vegas flights
Miami to Denver flights
Fort Lauderdale to Boston flights
Fort Lauderdale to O'Hare Intl flights
Orlando to Denver flights
Miami to Atlanta flights
Fort Lauderdale to Denver flights
Orlando to Boston flights
West Palm Beach to LaGuardia flights
Miami to Boston flights
West Palm Beach to Newark flights
Fort Lauderdale to Seattle flights
Miami to O'Hare Intl flights
Tampa to Philadelphia flights
Jacksonville to Newark flights
Jacksonville to John F Kennedy Intl flights
Orlando to Midway flights
Fort Lauderdale to Baltimore flights
Orlando to Atlanta flights
Tampa to Baltimore flights
Tampa to O'Hare Intl flights
Fort Lauderdale to Reagan-National flights

Top 2 airlines flying from Gainesville to South Carolina

Discover the top 2 airlines that operate flights from Gainesville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$289Average$411FlexibilityNo cancel feeOn-time71%
DeltaCheapest$316Average$406FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.