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South Carolina

$235+ Cheap flights from Gainesville (GNV) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel.
GNV — CHS
Feb 19 — Feb 261
Thu 2/19
Thu 2/26
1 adult, Economy
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Cheap flight deals from Gainesville to South Carolina

Cheapest flights from Gainesville to South Carolina
Explore the most affordable flight options available from Gainesville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

This American Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:01 pm
GNV
-
CLT
Nonstop1h 54m
American Airlines
Tue 2/2410:16 pm
CLT
-
GNV
Nonstop1h 40m
American Airlines
Deal found 1/18$235
This American Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/137:45 pm
GNV
-
CLT
Nonstop1h 54m
American Airlines
Mon 2/1610:45 pm
CLT
-
GNV
Nonstop1h 40m
American Airlines
Deal found 1/18$255
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/137:00 pm
GNV
-
CLT
1 stop4h 49m
Delta
Mon 2/165:25 am
CLT
-
GNV
1 stop3h 59m
Delta
Deal found 1/19$275
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/46:35 am
GNV
-
CLT
Nonstop1h 44m
American Airlines
Wed 2/119:45 pm
CLT
-
GNV
Nonstop1h 45m
American Airlines
Deal found 1/19$290
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/46:00 am
GNV
-
CLT
1 stop7h 28m
American Airlines
Fri 2/1310:45 pm
CLT
-
GNV
Nonstop1h 40m
American Airlines
Deal found 1/19$300
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/410:11 am
GNV
-
CLT
1 stop3h 27m
Delta
Wed 2/119:59 am
CLT
-
GNV
1 stop6h 05m
Delta
Deal found 1/19$310
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:45 pm
GNV
-
CLT
Nonstop1h 54m
American Airlines
Sun 2/229:10 am
CLT
-
GNV
Nonstop1h 49m
American Airlines
Deal found 1/20$315
This American Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:05 am
GNV
-
CLT
Nonstop1h 50m
American Airlines
Sat 5/168:55 pm
CLT
-
GNV
Nonstop1h 44m
American Airlines
Deal found 1/18$333
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:05 pm
GNV
-
CLT
1 stop4h 52m
Delta
Sat 5/1611:00 am
CLT
-
GNV
1 stop5h 26m
Delta
Deal found 1/20$353
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/76:00 am
GNV
-
GSP
1 stop5h 08m
Delta
Sun 2/85:40 am
GSP
-
GNV
1 stop3h 44m
Delta
Deal found 1/20$407
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/76:00 am
GNV
-
GSP
2 stops9h 14m
American Airlines
Sun 2/86:56 pm
GSP
-
GNV
1 stop5h 01m
American Airlines
Deal found 1/20$412

Find flight deals from Gainesville to South Carolina

Keep the following information in mind while searching for Gainesville to South Carolina flight deals. Data was last updated January 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$235
(American Airlines)
Provider with most accurate pricing for Gainesville Regional-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Gainesville Regional-Myrtle Beach Intl flights.
Search Deals
From Gainesville Regional to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Gainesville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from Gainesville to South Carolina that are best for you.

Fly from

Gainesville

Fly to

South Carolina

Route

Depart

Return

Price

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Thu 2/19

6:24 am-8:20 am

Nonstop1h 56m

Charlotte Douglas

Mon 2/23

10:45 pm-12:25 am

Nonstop1h 40m

$235

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Fri 2/20

7:45 pm-9:39 pm

Nonstop1h 54m

Charlotte Douglas

Sun 2/22

10:45 pm-12:25 am

Nonstop1h 40m

$235

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Fri 2/20

7:00 pm-11:49 pm

1 stop4h 49m

Charlotte Douglas

Sun 2/22

5:25 am-9:24 am

1 stop3h 59m

$255

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Fri 2/13

6:24 am-8:20 am

Nonstop1h 56m

Charlotte Douglas

Mon 2/16

10:45 pm-12:25 am

Nonstop1h 40m

$255

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Fri 2/13

7:00 pm-11:49 pm

1 stop4h 49m

Charlotte Douglas

Mon 2/16

5:25 am-9:24 am

1 stop3h 59m

$275

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Mon 2/2

6:35 am-8:19 am

Nonstop1h 44m

Charlotte Douglas

Mon 2/9

6:55 pm-11:57 pm

1 stop5h 02m

$300

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Wed 2/4

6:00 am-1:28 pm

1 stop7h 28m

Charlotte Douglas

Wed 2/11

9:45 pm-11:30 pm

Nonstop1h 45m

$300

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

Sat 2/7

6:00 am-11:08 am

1 stop5h 08m

Greenville

Sun 2/8

5:40 am-9:24 am

1 stop3h 44m

$407

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

Sat 2/7

6:00 am-3:14 pm

2 stops9h 14m

Greenville

Sun 2/8

6:56 pm-11:57 pm

1 stop5h 01m

$412

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Sat 3/21

5:34 pm-9:19 am

2 stops15h 45m

$238

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Showing 1-10 of 23 results
1
2
3

Best time to book a flight from Gainesville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Gainesville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Gainesville to South Carolina

What is the cheapest month to book a flight from Gainesville to South Carolina?

Currently, February is the cheapest month in which you can book a flight from Gainesville to South Carolina (average of $40). Flying from Gainesville to South Carolina in January is currently the most expensive (average of $75). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 20, 2026.
Read through reviews of airlines operating flights from Gainesville to South Carolina, such as Delta. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,077 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,077 reviews
Delta
7.9
Good
8,077 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Gainesville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Gainesville to South Carolina?

    If you book a flight to South Carolina from Gainesville, you will be flying from Gainesville Regional, which is the city’s only airport. Gainesville Regional (GNV) is located 4.2 mi from the center of Gainesville.

  • How long is the flight from Gainesville to South Carolina?

    Departing from Gainesville to South Carolina will take you 1h 56m. The distance between Gainesville and South Carolina is about 390 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Gainesville to South Carolina?

    Most travelers choose Gainesville Regional - Charlotte Douglas, Gainesville Regional - Myrtle Beach Intl or Gainesville Regional - Greenville when deciding on the best route from Gainesville to South Carolina.

  • Can I find deals for flights from Gainesville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Gainesville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Gainesville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Gainesville to South Carolina.

  • Can I find deals for business class flights from Gainesville to South Carolina?

    Yes. Cheapflights offers flight deals from Gainesville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Gainesville to South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Gainesville to South Carolina (average of $40). Flying from Gainesville to South Carolina in January is currently the most expensive (average of $75). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Gainesville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Gainesville to South Carolina

Discover the top airline that operate flights from Gainesville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$351Average$442FlexibilityNo cancel feeOn-timeN/A

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