HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$249+ Cheap flights from Gainesville (GNV) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
GNV — CHS
Apr 16 — Apr 231
Thu 4/16
Thu 4/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Gainesville to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Gainesville to South Carolina

Cheapest flights from Gainesville to South Carolina
Explore the most affordable flight options available from Gainesville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.

This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:38 am
GNV
-
MYR
1 stop4h 01m
Delta
Tue 5/266:00 am
MYR
-
GNV
1 stop6h 22m
Delta
Deal found 3/14$367
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:05 pm
GNV
-
GSP
1 stop4h 32m
Delta
Sun 10/185:40 am
GSP
-
GNV
1 stop3h 44m
Delta
Deal found 3/14$377
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:05 am
GNV
-
MYR
1 stop5h 24m
American Airlines
Tue 5/264:43 pm
MYR
-
GNV
2 stops7h 16m
American Airlines
Deal found 3/14$382
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:03 pm
GNV
-
GSP
1 stop4h 53m
Delta
Sun 4/265:40 am
GSP
-
GNV
1 stop3h 44m
Delta
Deal found 3/12$387
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:49 pm
GNV
-
CLT
Nonstop1h 51m
American Airlines
Sun 4/2612:59 pm
CLT
-
GNV
Nonstop1h 42m
American Airlines
Deal found 3/13$404
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:59 pm
GNV
-
GSP
1 stop3h 58m
American Airlines
Sun 4/265:20 am
GSP
-
GNV
1 stop5h 37m
American Airlines
Deal found 3/16$407
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1510:10 am
GNV
-
CLT
1 stop3h 33m
Delta
Sat 5/25:30 am
CLT
-
GNV
1 stop3h 54m
Delta
Deal found 3/13$413
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:05 pm
GNV
-
GSP
1 stop4h 38m
Delta
Sun 5/108:45 am
GSP
-
GNV
1 stop6h 10m
Delta
Deal found 3/15$433
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:47 pm
GNV
-
CLT
Nonstop1h 48m
American Airlines
Sat 5/29:10 am
CLT
-
GNV
Nonstop1h 47m
American Airlines
Deal found 3/13$433
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/174:54 pm
GNV
-
CLT
Nonstop1h 50m
American Airlines
Sat 3/285:40 pm
CLT
-
GNV
Nonstop1h 40m
American Airlines
Deal found 3/13$435
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:03 pm
GNV
-
CLT
1 stop4h 50m
Delta
Fri 5/14:54 pm
CLT
-
GNV
1 stop5h 45m
Delta
Deal found 3/13$444
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:45 pm
GNV
-
MYR
1 stop4h 10m
American Airlines
Tue 3/316:54 am
MYR
-
GNV
1 stop4h 21m
American Airlines
Deal found 3/12$447

Find flight deals from Gainesville to South Carolina

Keep the following information in mind while searching for Gainesville to South Carolina flight deals. Data was last updated March 17, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$367
(Delta)

One-way from

$249
(Delta)
Provider with most accurate pricing for Gainesville Regional-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Gainesville Regional-Myrtle Beach Intl flights.
Search Deals
From Gainesville Regional to South Carolina
Search Deals
One-way flight from Gainesville Regional to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Gainesville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Gainesville to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GainesvilleMyrtle Beach

GNV - MYR

GNVMYR

Gainesville Regional

Tue 5/19

6:38 am-10:39 am

1 stop4h 01m

Myrtle Beach Intl

Tue 5/26

6:00 am-12:22 pm

1 stop6h 22m

$367

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

Fri 5/8

7:05 pm-11:43 pm

1 stop4h 38m

Greenville

Sun 5/10

8:45 am-2:55 pm

1 stop6h 10m

$387

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

Fri 4/24

7:03 pm-11:56 pm

1 stop4h 53m

Greenville

Sun 4/26

5:40 am-9:24 am

1 stop3h 44m

$387

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

Fri 5/8

7:05 pm-11:43 pm

1 stop4h 38m

Greenville

Mon 5/11

10:09 am-2:55 pm

1 stop4h 46m

$387

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Tue 4/14

6:05 am-7:55 am

Nonstop1h 50m

Charlotte Douglas

Tue 4/21

9:20 am-11:07 am

Nonstop1h 47m

$404

GainesvilleGreenville

GNV - GSP

GNVGSP

Gainesville Regional

Thu 5/7

7:05 pm-11:43 pm

1 stop4h 38m

Greenville

Sun 5/10

8:45 am-2:55 pm

1 stop6h 10m

$433
Quickest round-trip

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Fri 8/21

1:57 pm-3:39 pm

Nonstop1h 42m

Charlotte Douglas

Mon 8/24

7:10 am-8:52 am

Nonstop1h 42m

$435

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Wed 4/15

7:03 pm-11:53 pm

1 stop4h 50m

Charlotte Douglas

Fri 5/1

4:54 pm-10:39 pm

1 stop5h 45m

$444

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Wed 4/22

7:03 pm-11:53 pm

1 stop4h 50m

Charlotte Douglas

Sun 4/26

5:30 am-9:24 am

1 stop3h 54m

$444

GainesvilleCharlotte

GNV - CLT

GNVCLT

Gainesville Regional

Wed 4/15

6:00 am-11:11 am

1 stop5h 11m

Charlotte Douglas

Thu 4/30

5:30 am-9:24 am

1 stop3h 54m

$444

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/15

Showing 1-10 of 36 resultsSorted by cheapest first
1
2
3
4

Best time to book a flight from Gainesville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Gainesville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Gainesville to South Carolina

What is the cheapest month to book a flight from Gainesville to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Gainesville to South Carolina (average of $46). Flying from Gainesville to South Carolina in February is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 17, 2026.
Read through reviews of airlines operating flights from Gainesville to South Carolina, such as Delta. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,288 reviews

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,288 reviews
Delta
7.9
Good
8,288 reviews

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Gainesville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Gainesville to South Carolina?

    If you book a flight to South Carolina from Gainesville, you will be flying from Gainesville Regional, which is the city’s only airport. Gainesville Regional (GNV) is located 4.2 mi from the center of Gainesville.

  • How long is the flight from Gainesville to South Carolina?

    Departing from Gainesville to South Carolina will take you 1h 50m. The distance between Gainesville and South Carolina is about 390 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Gainesville to South Carolina?

    Most travelers choose Gainesville Regional - Charlotte Douglas, Gainesville Regional - Greenville or Gainesville Regional - Myrtle Beach Intl when deciding on the best route from Gainesville to South Carolina.

  • Can I find deals for flights from Gainesville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Gainesville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Gainesville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Gainesville to South Carolina.

  • Can I find deals for business class flights from Gainesville to South Carolina?

    Yes. Cheapflights offers flight deals from Gainesville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Gainesville to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Gainesville to South Carolina (average of $46). Flying from Gainesville to South Carolina in February is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Gainesville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Miami to John F Kennedy Intl flights
Fort Lauderdale to LaGuardia flights
Fort Lauderdale to Newark flights
Miami to LaGuardia flights
Miami to Newark flights
Fort Lauderdale to John F Kennedy Intl flights
Orlando to John F Kennedy Intl flights
Orlando to Las Vegas flights
Orlando to Newark flights
Orlando to LaGuardia flights
Tampa to Newark flights
Tampa to LaGuardia flights
Orlando to Seattle flights
West Palm Beach to Newark flights
Tampa to John F Kennedy Intl flights
Orlando to Los Angeles flights
Tampa to Seattle flights
Fort Lauderdale to Las Vegas flights
West Palm Beach to John F Kennedy Intl flights
Orlando to Denver flights
Orlando to O'Hare Intl flights
Orlando to Dallas/Fort Worth flights
Tampa to Las Vegas flights
Tampa to Denver flights
Miami to Los Angeles flights
Miami to Las Vegas flights
Miami to Seattle flights
Orlando to Dulles Intl flights
Orlando to Baltimore flights
Tampa to Boston flights
West Palm Beach to LaGuardia flights
Fort Lauderdale to Los Angeles flights
Miami to Reagan-National flights
Orlando to Reagan-National flights
Orlando to Philadelphia flights
Tampa to O'Hare Intl flights
Fort Lauderdale to Atlanta flights
Orlando to Hobby flights
Miami to Denver flights
Fort Lauderdale to Denver flights
Fort Lauderdale to Seattle flights
Fort Lauderdale to Dallas/Fort Worth flights
Fort Lauderdale to Baltimore flights
Miami to San Francisco flights
Miami to Boston flights
Miami to Baltimore flights
Tampa to Dulles Intl flights
Fort Myers to Newark flights
Fort Lauderdale to Boston flights
Orlando to Boston flights

Top airline flying from Gainesville to South Carolina

Discover the top airline that operate flights from Gainesville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$355Average$485FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.