How long is the flight from Mississippi to Santo Domingo?

Spirit Airlines, Delta, and American Airlines can get you from Mississippi to Santo Domingo in just under 6h 21m. Your travel time can differ by up to 19h 30m. There are 1692 mi between Mississippi and Santo Domingo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

What are the most popular routes from Mississippi to Santo Domingo?

The most popular route from Mississippi to Santo Domingo is Jackson-Evers Intl - Santo Domingo Las Americas. You may also consider Memphis - Santo Domingo Las Americas or Baton Rouge Ryan - Santo Domingo Las Americas.

What is the cheapest time of day to fly from MS to SDQ?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to Santo Domingo as you normally would.

What airport do you fly into for flights to Santo Domingo from Mississippi?

Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Mississippi. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.

Can I find deals for flights from Mississippi to Santo Domingo that include hotel bookings?

Yes. In addition to deals on Mississippi to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mississippi to Santo Domingo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Santo Domingo.

Can I find deals for business class flights from Mississippi to Santo Domingo?

Yes. Cheapflights offers flight deals from Mississippi to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$250+ Flights from Mississippi to Santo Domingo

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Cheap flight deals from Mississippi to Santo Domingo

Cheapest flights from Mississippi to Santo Domingo
Explore the most affordable flight options available from Mississippi to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Wed 12/106:07 amBTR - SDQ

1 stop6h 35mDelta

Sun 12/143:57 pmSDQ - BTR

1 stop7h 56mDelta

Deal found 12/9

$763

Fri 12/124:20 pmJAN - SDQ

2 stops18h 08mAmerican Airlines

Fri 12/196:57 pmSDQ - JAN

2 stops15h 33mAmerican Airlines

Deal found 12/11

$815

Fri 12/125:48 amJAN - SDQ

1 stop6h 54mDelta

Fri 12/193:57 pmSDQ - JAN

1 stop9h 08mDelta

Deal found 12/11

$1,134

Sun 12/215:10 amJAN - SDQ

2 stops10h 41mAmerican Airlines

Sun 1/46:57 pmSDQ - JAN

2 stops19h 08mAmerican Airlines

Deal found 12/10

$1,205

Sat 12/207:50 pmJAN - SDQ

2 stops16h 26mAmerican Airlines

Sun 1/46:57 pmSDQ - JAN

2 stops19h 08mAmerican Airlines

Deal found 12/10

$1,293

Wed 12/107:00 amBTR - SDQ

2 stops14h 46mUnited Airlines

Sun 12/146:00 amSDQ - BTR

2 stops17h 13mUnited Airlines

Deal found 12/9

$1,397

Sun 12/216:00 amJAN - SDQ

1 stop6h 32mDelta

Sun 1/43:57 pmSDQ - JAN

1 stop9h 08mDelta

Deal found 12/10

$1,886

Sat 12/206:00 amJAN - SDQ

1 stop6h 32mDelta

Sun 1/43:57 pmSDQ - JAN

1 stop9h 08mDelta

Deal found 12/10

$2,020

Best flights from Mississippi to Santo Domingo
Discover carefully curated flight deals from Mississippi to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

Fri 1/301:21 pmMEM - SDQ

2 stops24h 14mMultiple Airlines

Thu 2/54:40 pmSDQ - MEM

2 stops20h 09mMultiple Airlines

Deal found 12/10

$466

Fri 1/3011:44 amMEM - SDQ

3 stops25h 51mSpirit Airlines

Thu 2/54:40 pmSDQ - MEM

3 stops20h 09mSpirit Airlines

Deal found 12/10

$472

Fri 1/306:00 amMEM - SDQ

1 stop6h 21mDelta

Thu 2/53:46 pmSDQ - MEM

1 stop7h 14mDelta

Deal found 12/10

$478

Fri 1/163:39 pmJAN - SDQ

2 stops20h 21mAmerican Airlines

Tue 1/206:00 amSDQ - JAN

2 stops19h 45mAmerican Airlines

Deal found 12/9

$517

Sat 1/247:00 amJAN - SDQ

2 stops14h 46mUnited Airlines

Wed 1/282:53 pmSDQ - JAN

2 stops22h 33mUnited Airlines

Deal found 12/9

$592

Thu 2/195:50 pmMEM - SDQ

1 stop13h 58mAmerican Airlines

Sun 2/226:43 pmSDQ - MEM

1 stop7h 15mAmerican Airlines

Deal found 12/10

$543

Sat 1/249:30 amBTR - SDQ

2 stops12h 16mUnited Airlines

Sat 1/316:00 amSDQ - BTR

2 stops17h 32mUnited Airlines

Deal found 12/10

$637

Wed 1/75:32 amJAN - SDQ

1 stop6h 49mDelta

Fri 2/273:42 pmSDQ - JAN

1 stop6h 35mDelta

Deal found 12/11

$709

Fri 1/165:32 amJAN - SDQ

1 stop6h 49mDelta

Tue 1/203:46 pmSDQ - JAN

1 stop9h 15mDelta

Deal found 12/9

$729

Last-minute flights from Mississippi to Santo Domingo
Discover last-minute flight deals from Mississippi to Santo Domingo. Data last updated December 12, 2025 and is based on user searches.

Fri 12/124:20 pmJAN - SDQ

2 stops18h 08mAmerican Airlines

Fri 12/196:57 pmSDQ - JAN

2 stops15h 33mAmerican Airlines

Deal found 12/11

$815

Fri 12/125:48 amJAN - SDQ

1 stop6h 54mDelta

Fri 12/193:57 pmSDQ - JAN

1 stop9h 08mDelta

Deal found 12/11

$1,134

Sun 12/215:10 amJAN - SDQ

2 stops10h 41mAmerican Airlines

Sun 1/46:57 pmSDQ - JAN

2 stops19h 08mAmerican Airlines

Deal found 12/10

$1,205

Wed 1/75:14 pmJAN - SDQ

2 stops17h 07mAmerican Airlines

Fri 2/2710:50 amSDQ - JAN

2 stops13h 07mAmerican Airlines

Deal found 12/11

$507

Wed 1/75:32 amJAN - SDQ

1 stop6h 49mDelta

Fri 2/273:42 pmSDQ - JAN

1 stop6h 35mDelta

Deal found 12/11

$709

Fri 1/163:39 pmJAN - SDQ

2 stops20h 21mAmerican Airlines

Tue 1/206:00 amSDQ - JAN

2 stops19h 45mAmerican Airlines

Deal found 12/9

$517

Fri 1/165:32 amJAN - SDQ

1 stop6h 49mDelta

Tue 1/203:46 pmSDQ - JAN

1 stop9h 15mDelta

Deal found 12/9

$729

Sat 1/247:00 amJAN - SDQ

2 stops14h 46mUnited Airlines

Wed 1/282:53 pmSDQ - JAN

2 stops22h 33mUnited Airlines

Deal found 12/9

$592

Sat 1/249:30 amBTR - SDQ

2 stops12h 16mUnited Airlines

Sat 1/316:00 amSDQ - BTR

2 stops17h 32mUnited Airlines

Deal found 12/10

$637

Fri 1/3011:44 amMEM - SDQ

3 stops25h 51mSpirit Airlines

Thu 2/54:40 pmSDQ - MEM

2 stops20h 09mSpirit Airlines

Deal found 12/10

$438

Fri 1/301:21 pmMEM - SDQ

2 stops24h 14mMultiple Airlines

Thu 2/54:40 pmSDQ - MEM

2 stops20h 09mMultiple Airlines

Deal found 12/10

$466

Fri 1/306:00 amMEM - SDQ

1 stop6h 21mDelta

Thu 2/53:46 pmSDQ - MEM

1 stop7h 14mDelta

Deal found 12/10

$478

One-way flights from Mississippi to Santo Domingo
Search for one-way flight options from Mississippi to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated December 12, 2025.

Sat 4/1111:14 amMEM - SDQ

2 stops13h 24mSpirit Airlines

Deal found 12/11

$250

Sat 4/115:56 amMEM - SDQ

1 stop14h 54mAmerican Airlines

Deal found 12/11

$287

Sat 4/1111:14 amMEM - SDQ

3 stops33h 31mMultiple Airlines

Deal found 12/11

$326

Sat 4/1112:00 pmMEM - SDQ

1 stop9h 46mUnited Airlines

Deal found 12/11

$725

Find flight deals from Mississippi to Santo Domingo

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Most trusted provider	eDreams 3 stars
Round-trip from	$438 (Mytrip)
One-way from	$250 (Mytrip)

Provider with most accurate pricing for Jackson-Evers Intl-Santo Domingo Las Americas flight deals.

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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Santo Domingo Las Americas flights.

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From Mississippi to Santo Domingo Las Americas

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One-way flight from Mississippi to Santo Domingo Las Americas

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Fri 1/30

1:21 pm-3:35 pm

2 stops24h 14m

Santo Domingo Las Americas

Thu 2/5

4:40 pm-10:49 am

2 stops20h 09m

$466

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Fri 1/30

11:44 am-3:35 pm

3 stops25h 51m

Santo Domingo Las Americas

Thu 2/5

4:40 pm-10:49 am

3 stops20h 09m

$472

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Fri 1/30

6:00 am-2:21 pm

1 stop6h 21m

Santo Domingo Las Americas

Thu 2/5

3:46 pm-9:00 pm

1 stop7h 14m

$478

JacksonSanto Domingo

JAN - SDQ

JANSDQ

Jackson-Evers Intl

Fri 1/16

3:39 pm-2:00 pm

2 stops20h 21m

Santo Domingo Las Americas

Tue 1/20

6:00 am-11:45 pm

2 stops19h 45m

$517

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Thu 2/19

5:50 pm-9:48 am

1 stop13h 58m

Santo Domingo Las Americas

Sun 2/22

6:43 pm-11:58 pm

1 stop7h 15m

$543

JacksonSanto Domingo

JAN - SDQ

JANSDQ

Jackson-Evers Intl

Sat 1/24

7:00 am-11:46 pm

2 stops14h 46m

Santo Domingo Las Americas

Wed 1/28

2:53 pm-11:26 am

2 stops22h 33m

$592

Baton RougeSanto Domingo

BTR - SDQ

BTRSDQ

Baton Rouge Ryan

Sat 1/24

9:30 am-11:46 pm

2 stops12h 16m

Santo Domingo Las Americas

Sat 1/31

6:00 am-9:32 pm

2 stops17h 32m

$637

JacksonSanto Domingo

JAN - SDQ

JANSDQ

Jackson-Evers Intl

Wed 1/7

5:32 am-2:21 pm

1 stop6h 49m

Santo Domingo Las Americas

Fri 2/27

3:42 pm-8:17 pm

1 stop6h 35m

$709

JacksonSanto Domingo

JAN - SDQ

JANSDQ

Jackson-Evers Intl

Fri 1/16

5:32 am-2:21 pm

1 stop6h 49m

Santo Domingo Las Americas

Tue 1/20

3:46 pm-11:01 pm

1 stop9h 15m

$729

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Sat 4/11

11:14 am-1:38 am

2 stops13h 24m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 12 results

Best time to book a flight from Mississippi to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Mississippi with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Santo Domingo

No data available for this route at this time. Please check back soon.

Related info for your journey

What airport do you fly into for flights to Santo Domingo from Mississippi?
Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Mississippi. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.
How long is the flight from Mississippi to Santo Domingo?
Spirit Airlines, Delta, and American Airlines can get you from Mississippi to Santo Domingo in just under 6h 21m. Your travel time can differ by up to 19h 30m. There are 1692 mi between Mississippi and Santo Domingo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the most popular routes from Mississippi to Santo Domingo?
The most popular route from Mississippi to Santo Domingo is Jackson-Evers Intl - Santo Domingo Las Americas. You may also consider Memphis - Santo Domingo Las Americas or Baton Rouge Ryan - Santo Domingo Las Americas.
Can I find deals for flights from Mississippi to Santo Domingo that include hotel bookings?
Yes. In addition to deals on Mississippi to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mississippi to Santo Domingo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Santo Domingo.
Can I find deals for business class flights from Mississippi to Santo Domingo?
Yes. Cheapflights offers flight deals from Mississippi to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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$250+ Cheap flights from Mississippi to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/11. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Mississippi to Santo Domingo with Cheapflights

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2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Mississippi to Santo Domingo

Cheapest flights from Mississippi to Santo DomingoExplore the most affordable flight options available from Mississippi to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Explore the most affordable flight options available from Mississippi to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Find flight deals from Mississippi to Santo Domingo

Keep the following information in mind while searching for Mississippi to Santo Domingo flight deals. Data was last updated December 12, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to Santo Domingo that are best for you.

Best time to book a flight from Mississippi to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Mississippi with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Santo Domingo

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Santo Domingo from Mississippi?

How long is the flight from Mississippi to Santo Domingo?

What are the most popular routes from Mississippi to Santo Domingo?

Can I find deals for flights from Mississippi to Santo Domingo that include hotel bookings?

How can I find direct flights from Mississippi to Santo Domingo?

Can I find deals for business class flights from Mississippi to Santo Domingo?

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Cheapest flights from Mississippi to Santo Domingo
Explore the most affordable flight options available from Mississippi to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.