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Santo Domingo

$281+ Cheap flights from Mississippi to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/26. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — SDQ
Jul 1 — Jul 81
Tue 7/1
Tue 7/8
1 adult, Economy
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Cheap flight deals from Mississippi to Santo Domingo

Keep the following information in mind while searching for Mississippi to Santo Domingo flight deals. Data was last updated June 26, 2025.

Round-trip from

$399
(FlightHub)

One-way from

$281
(American Airlines)
From Mississippi to Santo Domingo Las Americas
Search Deals
One-way flight from Mississippi to Santo Domingo Las Americas
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Find flight deals from Mississippi to Santo Domingo

Cheapest flights from Mississippi to Santo Domingo
Explore the most affordable flight options available from Mississippi to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2025.

This FlightHub deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/105:00 amMEM - SDQ
2 stops19h 41mSpirit Airlines
Mon 9/157:30 amSDQ - MEM
1 stop16h 27mSpirit Airlines
Deal found 6/25$399
This Delta deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/235:45 amJAN - SDQ
1 stop7h 02mDelta
Tue 10/213:15 pmSDQ - JAN
1 stop9h 06mDelta
Deal found 6/25$465
This Delta deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:45 amMEM - SDQ
1 stop5h 37mDelta
Mon 9/156:10 amSDQ - MEM
1 stop10h 45mDelta
Deal found 6/25$475
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:00 amMEM - SDQ
2 stops13h 30mAmerican Airlines
Mon 9/157:00 amSDQ - MEM
2 stops15h 47mAmerican Airlines
Deal found 6/25$479
This Delta deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:00 amBTR - SDQ
1 stop6h 53mDelta
Fri 10/243:15 pmSDQ - BTR
1 stop7h 45mDelta
Deal found 6/25$525
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:12 pmBTR - SDQ
2 stops17h 13mAmerican Airlines
Fri 10/243:30 pmSDQ - BTR
2 stops19h 47mAmerican Airlines
Deal found 6/25$529
This Mytrip deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/295:49 pmMEM - SDQ
3 stops21h 40mMultiple Airlines
Thu 7/37:15 amSDQ - MEM
2 stops27h 07mMultiple Airlines
Deal found 6/25$753
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/87:00 amJAN - SDQ
2 stops17h 50mUnited Airlines
Fri 8/151:10 pmSDQ - JAN
2 stops27h 51mUnited Airlines
Deal found 6/24$822
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:48 pmJAN - SDQ
2 stops17h 12mAmerican Airlines
Sun 1/46:45 amSDQ - JAN
2 stops17h 22mAmerican Airlines
Deal found 6/25$1,017

Cheapflights Fare Finder

Customize your flight search to find flights from Mississippi to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 26, 2025.
Use the filters below to find and compare flights from Mississippi to Santo Domingo that are best for you.

Fly from

Mississippi

Fly to

Santo Domingo

Route

Depart

Return

Price

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 9/10

5:00 am-1:41 am

2 stops19h 41m

Santo Domingo Las Americas

Mon 9/15

7:30 am-10:57 pm

1 stop16h 27m

$399

JacksonSanto Domingo

JAN - SDQ

JANSDQ

Jackson-Evers Intl

Tue 9/23

5:45 am-1:47 pm

1 stop7h 02m

Santo Domingo Las Americas

Tue 10/21

3:15 pm-11:21 pm

1 stop9h 06m

$465

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 9/10

6:45 am-1:22 pm

1 stop5h 37m

Santo Domingo Las Americas

Mon 9/15

6:10 am-3:55 pm

1 stop10h 45m

$475

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 9/10

6:00 am-8:30 pm

2 stops13h 30m

Santo Domingo Las Americas

Mon 9/15

7:00 am-9:47 pm

2 stops15h 47m

$479

Baton RougeSanto Domingo

BTR - SDQ

BTRSDQ

Baton Rouge Ryan

Fri 10/17

6:00 am-1:53 pm

1 stop6h 53m

Santo Domingo Las Americas

Fri 10/24

3:15 pm-10:00 pm

1 stop7h 45m

$525

Baton RougeSanto Domingo

BTR - SDQ

BTRSDQ

Baton Rouge Ryan

Fri 10/17

8:12 pm-2:25 pm

2 stops17h 13m

Santo Domingo Las Americas

Fri 10/24

3:30 pm-10:17 am

2 stops19h 47m

$529

JacksonSanto Domingo

JAN - SDQ

JANSDQ

Jackson-Evers Intl

Fri 8/8

7:00 am-1:50 am

2 stops17h 50m

Santo Domingo Las Americas

Fri 8/15

1:10 pm-4:01 pm

2 stops27h 51m

$822

JacksonSanto Domingo

JAN - SDQ

JANSDQ

Jackson-Evers Intl

Sun 12/21

4:48 pm-12:00 pm

2 stops17h 12m

Santo Domingo Las Americas

Sun 1/4

6:45 am-10:07 pm

2 stops17h 22m

$1,017

JacksonSanto Domingo

JAN - SDQ

JANSDQ

Jackson-Evers Intl

Sat 7/26

4:10 pm-9:15 am

2 stops16h 05m

$281

Baton RougeSanto Domingo

BTR - SDQ

BTRSDQ

Baton Rouge Ryan

Sun 7/6

6:00 am-1:21 pm

1 stop6h 21m

$316

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/26

Showing 1-10 of 12 results
1
2

Best time to book a flight from Mississippi to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Santo Domingo
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated June 26, 2025.
Read through reviews of airlines operating flights from Mississippi to Santo Domingo, such as Delta, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,964 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,964 reviews
Delta
8.0
Very good
7,964 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,838 reviews
Delta
8.0
Very good
7,964 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,964 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Spirit Airlines
6.3
Okay
8,089 reviews
Delta
8.0
Very good
7,964 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Mississippi?

    Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Mississippi. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.

  • What are the cheapest airlines to fly from Mississippi to Santo Domingo one-way?

    $281 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $316 and $623, respectively.

  • What are the most popular routes from Mississippi to Santo Domingo?

    The most popular route from Mississippi to Santo Domingo is Jackson-Evers Intl - Santo Domingo Las Americas. You may also consider Memphis - Santo Domingo Las Americas or Baton Rouge Ryan - Santo Domingo Las Americas.

  • Can I find deals for flights from Mississippi to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Mississippi to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Santo Domingo.

  • Can I find deals for business class flights from Mississippi to Santo Domingo?

    Yes. Cheapflights offers flight deals from Mississippi to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Mississippi to Santo Domingo (average of $362). Flying from Mississippi to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mississippi?

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Alternative routes for Mississippi to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Mississippi to Santo Domingo

Discover the top airline that operate flights from Mississippi to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$454Average$454FlexibilityNo cancel feeOn-time71%

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