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Santo Domingo

$149+ Cheap flights from Mississippi to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/8. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — SDQ
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Mississippi to Santo Domingo

Cheapest flights from Mississippi to Santo Domingo
Explore the most affordable flight options available from Mississippi to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:03 am
MEM
-
SDQ
1 stop25h 53m
Multiple Airlines
Thu 3/512:31 pm
SDQ
-
MEM
1 stop20h 43m
Multiple Airlines
Deal found 1/29$327
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:01 pm
MEM
-
SDQ
1 stop17h 19m
Multiple Airlines
Thu 3/512:31 pm
SDQ
-
MEM
1 stop20h 43m
Multiple Airlines
Deal found 1/29$334
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:03 am
MEM
-
SDQ
1 stop25h 53m
Multiple Airlines
Wed 3/43:32 pm
SDQ
-
MEM
1 stop27h 54m
Multiple Airlines
Deal found 1/29$338
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:15 am
MEM
-
SDQ
1 stop20h 24m
Multiple Airlines
Thu 3/512:31 pm
SDQ
-
MEM
1 stop20h 43m
Multiple Airlines
Deal found 1/29$343
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:01 pm
MEM
-
SDQ
1 stop17h 19m
Multiple Airlines
Wed 3/43:32 pm
SDQ
-
MEM
1 stop27h 54m
Multiple Airlines
Deal found 1/29$344
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:04 pm
MEM
-
SDQ
2 stops17h 16m
Multiple Airlines
Thu 3/512:31 pm
SDQ
-
MEM
1 stop20h 43m
Multiple Airlines
Deal found 1/29$345
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:01 pm
MEM
-
SDQ
1 stop17h 19m
Multiple Airlines
Tue 3/31:11 pm
SDQ
-
MEM
1 stop23h 09m
Multiple Airlines
Deal found 1/29$352
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:15 am
MEM
-
SDQ
1 stop20h 24m
Multiple Airlines
Wed 3/43:32 pm
SDQ
-
MEM
1 stop27h 54m
Multiple Airlines
Deal found 1/29$354
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:04 pm
MEM
-
SDQ
2 stops17h 16m
Multiple Airlines
Wed 3/43:32 pm
SDQ
-
MEM
1 stop27h 54m
Multiple Airlines
Deal found 1/29$355
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2411:15 am
MEM
-
SDQ
2 stops25h 05m
Multiple Airlines
Thu 3/512:31 pm
SDQ
-
MEM
1 stop20h 43m
Multiple Airlines
Deal found 1/29$359
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:37 pm
BTR
-
SDQ
2 stops16h 43m
American Airlines
Thu 11/56:00 am
SDQ
-
BTR
2 stops17h 45m
American Airlines
Deal found 1/26$603
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:00 am
JAN
-
SDQ
2 stops14h 46m
United Airlines
Thu 10/295:00 am
SDQ
-
JAN
2 stops15h 28m
United Airlines
Deal found 1/28$653

Find flight deals from Mississippi to Santo Domingo

Keep the following information in mind while searching for Mississippi to Santo Domingo flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$327
(Kiwi.com)

One-way from

$149
(Kiwi.com)
Provider with most accurate pricing for Jackson-Evers Intl-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Santo Domingo Las Americas flights.
Search Deals
From Mississippi to Santo Domingo Las Americas
Search Deals
One-way flight from Mississippi to Santo Domingo Las Americas
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Mississippi to Santo Domingo that are best for you.

Fly from

Mississippi

Fly to

Santo Domingo

Route

Depart

Return

Price

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Mon 3/2

8:03 am-11:56 am

1 stop25h 53m

Santo Domingo Las Americas

Thu 3/5

12:31 pm-7:14 am

1 stop20h 43m

$327

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Mon 3/2

8:03 am-11:56 am

1 stop25h 53m

Santo Domingo Las Americas

Wed 3/4

3:32 pm-5:26 pm

1 stop27h 54m

$338

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Thu 2/26

7:04 pm-2:20 pm

2 stops17h 16m

Santo Domingo Las Americas

Thu 3/5

12:31 pm-7:14 am

1 stop20h 43m

$345

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Sun 3/1

7:04 pm-4:29 pm

2 stops19h 25m

Santo Domingo Las Americas

Wed 3/4

3:32 pm-5:26 pm

1 stop27h 54m

$348

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Thu 2/26

7:04 pm-2:20 pm

2 stops17h 16m

Santo Domingo Las Americas

Wed 3/4

3:32 pm-5:26 pm

1 stop27h 54m

$355

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 2/25

11:15 am-11:26 am

1 stop22h 11m

Santo Domingo Las Americas

Thu 3/5

12:31 pm-7:14 am

1 stop20h 43m

$365

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Fri 2/27

5:09 pm-2:20 pm

1 stop19h 11m

Santo Domingo Las Americas

Thu 3/5

12:31 pm-7:14 am

1 stop20h 43m

$366

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Mon 3/2

5:09 pm-2:20 pm

1 stop19h 11m

Santo Domingo Las Americas

Sat 3/7

3:32 pm-5:20 pm

2 stops27h 48m

$371

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 2/25

11:15 am-11:26 am

1 stop22h 11m

Santo Domingo Las Americas

Wed 3/4

3:32 pm-5:26 pm

1 stop27h 54m

$376

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Tue 2/24

11:15 am-2:20 pm

2 stops25h 05m

Santo Domingo Las Americas

Fri 3/6

11:46 am-10:20 am

1 stop24h 34m

$377

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 18 results
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Best time to book a flight from Mississippi to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Santo Domingo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Mississippi?

    Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Mississippi. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.

  • How long is the flight from Mississippi to Santo Domingo?

    American Airlines can get you from Mississippi to Santo Domingo in just under 17h 18m. Your travel time can differ by up to . There are 1588 mi between Mississippi and Santo Domingo.

  • What are the most popular routes from Mississippi to Santo Domingo?

    The most popular route from Mississippi to Santo Domingo is Memphis - Santo Domingo Las Americas. You may also consider Baton Rouge Ryan - Santo Domingo Las Americas or Jackson-Evers Intl - Santo Domingo Las Americas.

  • Can I find deals for flights from Mississippi to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Mississippi to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Santo Domingo.

  • Can I find deals for business class flights from Mississippi to Santo Domingo?

    Yes. Cheapflights offers flight deals from Mississippi to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Mississippi to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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