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Santo Domingo

$135+ Cheap flights from Mississippi to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — SDQ
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
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Cheap flight deals from Mississippi to Santo Domingo

Keep the following information in mind while searching for Mississippi to Santo Domingo flight deals. Data was last updated August 18, 2025.

Round-trip from

$361
(Kiwi.com)

One-way from

$135
(Expedia)
From Mississippi to Santo Domingo Las Americas
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One-way flight from Mississippi to Santo Domingo Las Americas
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Find flight deals from Mississippi to Santo Domingo

Cheapest flights from Mississippi to Santo Domingo
Explore the most affordable flight options available from Mississippi to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/177:00 amMEM - SDQ
2 stops32h 00mMultiple Airlines
Wed 10/83:54 pmSDQ - MEM
1 stop16h 48mMultiple Airlines
Deal found 8/18$361
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:00 amMEM - SDQ
2 stops32h 00mMultiple Airlines
Wed 10/83:54 pmSDQ - MEM
1 stop16h 48mMultiple Airlines
Deal found 8/17$367
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:00 amMEM - SDQ
1 stop28h 15mSpirit Airlines
Thu 10/163:54 pmSDQ - MEM
1 stop18h 06mSpirit Airlines
Deal found 8/18$374
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/258:35 pmMEM - SDQ
2 stops18h 25mSpirit Airlines
Thu 10/233:54 pmSDQ - MEM
1 stop18h 06mSpirit Airlines
Deal found 8/18$386
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/303:01 pmMEM - SDQ
2 stops23h 59mSpirit Airlines
Thu 10/163:54 pmSDQ - MEM
1 stop18h 06mSpirit Airlines
Deal found 8/18$390
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/57:55 pmMEM - SDQ
1 stop16h 12mSpirit Airlines
Mon 9/85:05 pmSDQ - MEM
2 stops31h 45mSpirit Airlines
Deal found 8/17$396
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/28:35 pmMEM - SDQ
2 stops18h 25mSpirit Airlines
Thu 10/163:54 pmSDQ - MEM
1 stop18h 06mSpirit Airlines
Deal found 8/18$403
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:00 amMEM - SDQ
1 stop28h 15mSpirit Airlines
Wed 10/223:54 pmSDQ - MEM
2 stops24h 18mSpirit Airlines
Deal found 8/18$407
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/303:01 pmMEM - SDQ
2 stops23h 59mSpirit Airlines
Wed 10/223:54 pmSDQ - MEM
2 stops24h 18mSpirit Airlines
Deal found 8/18$409
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/243:01 pmMEM - SDQ
2 stops23h 59mSpirit Airlines
Wed 10/223:54 pmSDQ - MEM
2 stops24h 18mSpirit Airlines
Deal found 8/18$424
This FlightHub deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2512:06 pmMEM - SDQ
2 stops25h 42mSpirit Airlines
Tue 10/283:54 pmSDQ - MEM
2 stops28h 51mSpirit Airlines
Deal found 8/16$436
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/235:50 amJAN - SDQ
2 stops11h 09mDelta
Tue 9/306:03 amSDQ - JAN
2 stops12h 32mDelta
Deal found 8/18$469

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Mississippi to Santo Domingo that are best for you.

Fly from

Mississippi

Fly to

Santo Domingo

Route

Depart

Return

Price

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 9/17

7:00 am-4:00 pm

2 stops32h 00m

Santo Domingo Las Americas

Wed 10/8

3:54 pm-7:42 am

1 stop16h 48m

$361

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 10/1

7:00 am-12:15 pm

1 stop28h 15m

Santo Domingo Las Americas

Wed 10/8

3:54 pm-7:42 am

1 stop16h 48m

$362

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 10/1

7:00 am-12:15 pm

1 stop28h 15m

Santo Domingo Las Americas

Thu 10/23

3:54 pm-9:00 am

1 stop18h 06m

$374

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 9/24

7:00 am-12:15 pm

1 stop28h 15m

Santo Domingo Las Americas

Thu 10/23

3:54 pm-9:00 am

1 stop18h 06m

$374

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Wed 10/1

7:00 am-12:15 pm

1 stop28h 15m

Santo Domingo Las Americas

Thu 10/16

3:54 pm-9:00 am

1 stop18h 06m

$374

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Thu 9/25

8:35 pm-4:00 pm

2 stops18h 25m

Santo Domingo Las Americas

Thu 10/23

3:54 pm-9:00 am

1 stop18h 06m

$386

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Tue 9/30

3:01 pm-4:00 pm

2 stops23h 59m

Santo Domingo Las Americas

Thu 10/23

3:54 pm-9:00 am

1 stop18h 06m

$390

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Tue 9/23

3:01 pm-4:00 pm

2 stops23h 59m

Santo Domingo Las Americas

Thu 10/23

3:54 pm-9:00 am

1 stop18h 06m

$390

MemphisSanto Domingo

MEM - SDQ

MEMSDQ

Memphis

Tue 9/30

3:01 pm-4:00 pm

2 stops23h 59m

Santo Domingo Las Americas

Thu 10/16

3:54 pm-9:00 am

1 stop18h 06m

$390

JacksonSanto Domingo

JAN - SDQ

JANSDQ

Jackson-Evers Intl

Tue 9/23

5:50 am-5:59 pm

2 stops11h 09m

Santo Domingo Las Americas

Tue 9/30

6:03 am-5:35 pm

2 stops12h 32m

$469

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/18

Showing 1-10 of 26 results
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Best time to book a flight from Mississippi to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Santo Domingo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Mississippi?

    Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Mississippi. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.

  • How long is the flight from Mississippi to Santo Domingo?

    Spirit Airlines, Delta, and American Airlines can get you from Mississippi to Santo Domingo in just under 11h 09m. Your travel time can differ by up to 17h 06m. There are 1588 mi between Mississippi and Santo Domingo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Mississippi to Santo Domingo one-way?

    $135 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $306 and $336, respectively.

  • What are the most popular routes from Mississippi to Santo Domingo?

    The most popular route from Mississippi to Santo Domingo is Memphis - Santo Domingo Las Americas. You may also consider Jackson-Evers Intl - Santo Domingo Las Americas or Baton Rouge Ryan - Santo Domingo Las Americas.

  • Can I find deals for flights from Mississippi to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Mississippi to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Santo Domingo.

  • Can I find deals for business class flights from Mississippi to Santo Domingo?

    Yes. Cheapflights offers flight deals from Mississippi to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Mississippi to Santo Domingo (average of $362). Flying from Mississippi to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Mississippi to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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