$260+ Cheap flights from Missouri to Santiago de los Caballeros (STI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — STI
Mar 7 — Mar 141
1 adult, Economy
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Find cheap flights from Missouri to Santiago de los Caballeros with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Santiago de los Caballeros
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Cheapest flights from Missouri to Santiago de los CaballerosExplore the most affordable flight options available from Missouri to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
Explore the most affordable flight options available from Missouri to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:26 am
MCI
- STI
1 stop26h 09m
Spirit Airlines
Tue 3/243:43 pm
STI
- MCI
1 stop20h 46m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$368
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/711:26 am
MCI
- STI
1 stop26h 07m
Spirit Airlines
Wed 3/44:40 pm
STI
- MCI
1 stop19h 50m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$417
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/184:24 pm
MCI
- STI
2 stops21h 11m
Spirit Airlines
Tue 3/242:46 am
STI
- MCI
1 stop9h 43m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$441
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/511:26 am
MCI
- STI
1 stop26h 07m
Spirit Airlines
Tue 3/103:41 pm
STI
- MCI
2 stops24h 48m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$450
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:01 am
STL
- STI
1 stop8h 11m
United Airlines
Tue 6/22:07 pm
STI
- STL
1 stop10h 20m
United Airlines
Deal found 2/4![United Airlines logo]()
$539
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:50 am
STL
- STI
2 stops12h 04m
Delta
Wed 3/256:33 am
STI
- STL
2 stops10h 59m
Delta
Deal found 2/3![Delta logo]()
$543
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:15 am
STL
- STI
1 stop6h 15m
American Airlines
Wed 3/251:30 pm
STI
- STL
1 stop11h 28m
American Airlines
Deal found 2/2![American Airlines logo]()
$549
This Delta deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
STL
- STI
2 stops17h 14m
Delta
Tue 6/26:10 am
STI
- STL
1 stop11h 55m
Delta
Deal found 2/4![Delta logo]()
$553
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:20 am
STL
- STI
2 stops13h 41m
American Airlines
Tue 6/27:00 am
STI
- STL
2 stops14h 26m
American Airlines
Deal found 2/3![American Airlines logo]()
$569
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:14 am
STL
- STI
1 stop6h 17m
American Airlines
Sat 3/147:00 am
STI
- STL
1 stop28h 32m
American Airlines
Deal found 2/3![American Airlines logo]()
$607
Best flights from Missouri to Santiago de los CaballerosDiscover carefully curated flight deals from Missouri to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
Discover carefully curated flight deals from Missouri to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:26 am
MCI
- STI
1 stop26h 09m
Spirit Airlines
Tue 3/243:43 pm
STI
- MCI
1 stop20h 46m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:01 am
STL
- STI
1 stop8h 11m
United Airlines
Tue 6/22:07 pm
STI
- STL
1 stop10h 20m
United Airlines
Deal found 2/4![United Airlines logo]()
$539
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:32 am
STL
- STI
2 stops16h 22m
Delta
Wed 3/256:33 am
STI
- STL
2 stops10h 59m
Delta
Deal found 2/2![Delta logo]()
$543
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:15 am
STL
- STI
1 stop6h 15m
American Airlines
Wed 3/251:30 pm
STI
- STL
1 stop11h 28m
American Airlines
Deal found 2/2![American Airlines logo]()
$549
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/184:24 pm
MCI
- STI
2 stops45h 11m
Spirit Airlines
Tue 3/242:46 am
STI
- MCI
1 stop9h 43m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$458
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
STL
- STI
2 stops17h 14m
Delta
Tue 6/26:10 am
STI
- STL
2 stops18h 49m
Delta
Deal found 2/2![Delta logo]()
$553
Last-minute flights from Missouri to Santiago de los CaballerosDiscover last-minute flight deals from Missouri to Santiago de los Caballeros. Data last updated February 5, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Santiago de los Caballeros. Data last updated February 5, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/511:26 am
MCI
- STI
1 stop26h 07m
Spirit Airlines
Tue 3/103:41 pm
STI
- MCI
2 stops24h 48m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$450
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/711:26 am
MCI
- STI
1 stop26h 07m
Spirit Airlines
Wed 3/44:40 pm
STI
- MCI
1 stop19h 50m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$417
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:26 am
MCI
- STI
1 stop26h 09m
Spirit Airlines
Tue 3/243:43 pm
STI
- MCI
1 stop20h 46m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$368
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/184:24 pm
MCI
- STI
2 stops21h 11m
Spirit Airlines
Tue 3/242:46 am
STI
- MCI
1 stop9h 43m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$441
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/211:36 pm
STL
- STI
2 stops21h 55m
American Airlines
Sat 2/282:31 pm
STI
- STL
2 stops20h 04m
American Airlines
Deal found 2/3![American Airlines logo]()
$643
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:14 am
STL
- STI
1 stop6h 17m
American Airlines
Sat 3/147:00 am
STI
- STL
1 stop28h 32m
American Airlines
Deal found 2/3![American Airlines logo]()
$607
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:50 am
STL
- STI
2 stops12h 04m
Delta
Wed 3/256:33 am
STI
- STL
2 stops10h 59m
Delta
Deal found 2/3![Delta logo]()
$543
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:15 am
STL
- STI
1 stop6h 15m
American Airlines
Wed 3/251:30 pm
STI
- STL
1 stop11h 28m
American Airlines
Deal found 2/2![American Airlines logo]()
$549
One-way flights from Missouri to Santiago de los CaballerosSearch for one-way flight options from Missouri to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
Search for one-way flight options from Missouri to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2312:12 pm
MCI
- STI
1 stop25h 23m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$260
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:44 pm
MCI
- STI
2 stops17h 33m
American Airlines
Deal found 2/1![American Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:40 pm
MCI
- STI
2 stops19h 37m
American Airlines
Deal found 2/3![American Airlines logo]()
$375
This CheapOair deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/145:45 am
MCI
- STI
2 stops19h 04m
Spirit Airlines
Deal found 2/5![Spirit Airlines logo]()
$400
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:00 am
MCI
- STI
3 stops55h 35m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$412
Find flight deals from Missouri to Santiago de los Caballeros
Keep the following information in mind while searching for Missouri to Santiago de los Caballeros flight deals. Data was last updated February 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $368 (CheapOair) |
One-way from | $260 (CheapOair) |
Popular in | February |
Cheapest in | October |
Average price | $869 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Missouri to Santiago de los Caballeros that are best for you.
Fly from
Missouri
Fly to
Santiago de los Caballeros
Route
Depart
Return
Price
Kansas CitySantiago de los Caballeros
MCI - STI
MCISTI
Kansas City
Sun 2/15
11:26 am-3:35 pm
1 stop26h 09m
Santiago de los Caballeros
Tue 3/24
3:43 pm-11:29 am
1 stop20h 46m
$368
Kansas CitySantiago de los Caballeros
MCI - STI
MCISTI
Kansas City
Wed 2/18
4:24 pm-3:35 pm
2 stops45h 11m
Santiago de los Caballeros
Tue 3/24
2:46 am-11:29 am
1 stop9h 43m
$458
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Thu 5/28
6:01 am-3:12 pm
1 stop8h 11m
Santiago de los Caballeros
Tue 6/2
2:07 pm-11:27 pm
1 stop10h 20m
$539
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Tue 3/17
6:32 am-11:54 pm
2 stops16h 22m
Santiago de los Caballeros
Wed 3/25
6:33 am-4:32 pm
2 stops10h 59m
$543
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Tue 3/17
5:15 am-12:30 pm
1 stop6h 15m
Santiago de los Caballeros
Wed 3/25
1:30 pm-11:58 pm
1 stop11h 28m
$549
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Thu 5/28
6:00 am-12:14 am
2 stops17h 14m
Santiago de los Caballeros
Tue 6/2
6:10 am-11:59 pm
2 stops18h 49m
$553
Kansas CitySantiago de los Caballeros
MCI - STI
MCISTI
Kansas City
Mon 5/25
12:12 pm-2:35 pm
1 stop25h 23m
$260
Kansas CitySantiago de los Caballeros
MCI - STI
MCISTI
Kansas City
Sat 5/23
12:12 pm-2:35 pm
1 stop25h 23m
$260
Kansas CitySantiago de los Caballeros
MCI - STI
MCISTI
Kansas City
Mon 5/25
7:44 pm-2:17 pm
2 stops17h 33m
$271
Kansas CitySantiago de los Caballeros
MCI - STI
MCISTI
Kansas City
Sat 5/23
5:40 pm-2:17 pm
2 stops19h 37m
$375
Showing 1-10 of 11 results
Best time to book a flight from Missouri to Santiago de los Caballeros
Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Missouri with our price prediction graph.
MCI-STI
STL-STI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Santiago de los Caballeros
USMO-STI
MCI-STI
STL-STI
What is the cheapest month to book a flight from Missouri to Santiago de los Caballeros?
Currently, January is the cheapest month in which you can book a flight from Missouri to Santiago de los Caballeros (average of $255). Flying from Missouri to Santiago de los Caballeros in June is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to Santiago de los Caballeros
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Complete your trip
Complete your trip to Santiago de los Caballeros by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Santiago de los Caballeros by cabin class
Find flights from Missouri to Santiago de los Caballeros, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Santiago de los Caballeros flights
Browse other Missouri and Santiago de los Caballeros flight options. Last updated on February 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago de los Caballeros
Explore flights to Santiago de los Caballeros departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 5, 2026.
Missouri to Santiago de los Caballeros flights
Consider these flights traveling from Missouri to Santiago de los Caballeros.
Top 2 airlines flying from Missouri to Santiago de los Caballeros
Discover the top 2 airlines that operate flights from Missouri to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$522 | Average$629 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$538 | Average$609 | FlexibilityNo cancel fee | On-time69% |