What are the cheapest airlines to fly from Durham to Santiago de los Caballeros one-way?

To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $145. American Airlines flights start at $181 while deals on Delta start at $205 one-way.

What is the cheapest day to fly from Durham to Santiago de los Caballeros?

Travelers seeking maximum savings on their Durham to Santiago de los Caballeros flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santiago de los Caballeros ranges from 3.0 - 11.6 inches per month. December is typically the wettest month, when rainfall can reach 11.6 in. July is typically the driest time to visit Santiago de los Caballeros when rainfall is around 3.0 in.

If weather is an important factor for your trip to Santiago de los Caballeros, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

What are the most popular airlines that fly from Durham to Santiago de los Caballeros?

American Airlines, JetBlue and Delta are the most popular airlines when flying from Durham to Santiago de los Caballeros.

How far in advance should I book a flight from Durham to Santiago de los Caballeros?

Find a great deal and save up to 145% by booking at least 30 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Durham to Santiago de los Caballeros within the next two weeks, with the cheapest ticket starting at $442.

What is the cheapest month to fly from Durham to Santiago de los Caballeros?

The best pricing can be found in the month of September. Prices to Santiago de los Caballeros from Durham average $587. You can even find prices in September for less than $587, as users have found deals to Santiago de los Caballeros from as low as $353. The month of December appears to be one of the more expensive times to travel to Santiago de los Caballeros from Durham. Flying in the targeted month can save you up to 21%.

What airport do you fly into for flights to Santiago de los Caballeros from Durham?

Santiago de los Caballeros (STI) is the airport you will fly into if you book a flight from Durham to Santiago de los Caballeros. You should not have trouble finding flights to Santiago from Durham; the airport handles an average of 0 inbound flights from Durham per day. You should also have plenty of airline options to choose from since 4 airlines have flights to the Santiago de los Caballeros airport from Durham. It is only a 6.8 mi journey from Santiago (STI) to Santiago de los Caballeros’s city center.

How can I find direct flights from Durham to Santiago de los Caballeros?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Santiago de los Caballeros.

Can I find deals for business class flights from Durham to Santiago de los Caballeros?

Yes. Cheapflights offers flight deals from Durham to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$145+ Flights from Durham to Santiago de los Caballeros

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Cheapflights Tip: The best prices from Durham to Santiago de los Caballeros are usually found in September or March, booked 29 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Durham to Santiago de los Caballeros

Round-trip from	$319 (FlightHub)
One-way from	$145 (SmartFares)
Popular in	December
Cheapest in	September
Average price	$653

From Durham to Santiago de los Caballeros

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One-way flight from Durham to Santiago de los Caballeros

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Highest demand for flights based on searches. 1% potential increase in price ($9 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Durham to Santiago de los Caballeros

Cheapest flights from Durham to Santiago de los Caballeros
Explore the most affordable flight options available from Durham to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 31, 2025.

jue. 8/217:56 pmRDU - STI

1 stop13h 19mSpirit Airlines

dom. 9/712:10 pmSTI - RDU

1 stop26h 25mSpirit Airlines

Deal found 7/30

$319

lun. 9/112:06 pmRDU - STI

1 stop8h 42mAmerican Airlines

lun. 9/81:29 pmSTI - RDU

1 stop10h 16mAmerican Airlines

Deal found 7/29

$395

sáb. 9/137:03 pmRDU - STI

2 stops16h 02mMultiple Airlines

sáb. 9/2012:10 pmSTI - RDU

1 stop26h 25mMultiple Airlines

Deal found 7/30

$419

vie. 12/1910:27 amRDU - STI

1 stop5h 55mJetBlue

vie. 12/1911:01 pmSTI - RDU

1 stop10h 08mJetBlue

Deal found 7/31

$428

dom. 11/27:10 amRDU - STI

1 stop16h 34mDelta

sáb. 11/89:59 pmSTI - RDU

1 stop12h 53mDelta

Deal found 7/31

$433

Best flights from Durham to Santiago de los Caballeros
Discover carefully curated flight deals from Durham to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 31, 2025.

jue. 8/217:56 pmRDU - STI

1 stop13h 19mSpirit Airlines

dom. 9/712:10 pmSTI - RDU

1 stop26h 25mSpirit Airlines

Deal found 7/30

$319

lun. 9/112:06 pmRDU - STI

1 stop8h 42mAmerican Airlines

lun. 9/81:29 pmSTI - RDU

1 stop10h 16mAmerican Airlines

Deal found 7/29

$395

sáb. 9/137:03 pmRDU - STI

2 stops16h 02mMultiple Airlines

sáb. 9/2012:10 pmSTI - RDU

1 stop26h 25mMultiple Airlines

Deal found 7/30

$419

dom. 10/54:20 pmRDU - STI

1 stop20h 30mJetBlue

vie. 10/243:20 amSTI - RDU

1 stop13h 30mJetBlue

Deal found 7/30

$466

Last-minute flights from Durham to Santiago de los Caballeros
Discover last-minute flight deals from Durham to Santiago de los Caballeros. Data last updated julio 31, 2025 and is based on user searches.

mar. 8/198:00 amRDU - STI

2 stops25h 15mMultiple Airlines

mié. 9/310:20 amSTI - RDU

1 stop28h 15mMultiple Airlines

Deal found 7/30

$431

mar. 8/199:19 amRDU - STI

1 stop8h 39mJetBlue

mié. 9/32:00 pmSTI - RDU

1 stop25h 24mJetBlue

Deal found 7/30

$504

jue. 8/217:56 pmRDU - STI

1 stop13h 19mSpirit Airlines

dom. 9/712:10 pmSTI - RDU

1 stop26h 25mSpirit Airlines

Deal found 7/30

$319

jue. 8/218:00 amRDU - STI

2 stops12h 48mAmerican Airlines

dom. 9/71:29 pmSTI - RDU

2 stops19h 15mAmerican Airlines

Deal found 7/31

$442

One-way flights from Durham to Santiago de los Caballeros
Search for one-way flight options from Durham to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated julio 31, 2025.

dom. 10/59:23 amRDU - STI

1 stop25h 42mSpirit Airlines

Deal found 7/30

$145

lun. 9/18:00 amRDU - STI

2 stops12h 48mAmerican Airlines

Deal found 7/29

$181

mié. 9/1710:00 amRDU - STI

1 stop9h 11mDelta

Deal found 7/30

$205

mié. 9/175:14 pmRDU - STI

3 stops41h 49mMultiple Airlines

Deal found 7/30

$317

Cheapflights Fare Finder

Use the filters below to find and compare flights from Durham to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

jue. 8/21

7:56 pm-9:15 am

1 stop13h 19m

Santiago de los Caballeros

dom. 9/7

12:10 pm-2:35 pm

1 stop26h 25m

$319

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

lun. 9/1

12:06 pm-8:48 pm

1 stop8h 42m

Santiago de los Caballeros

lun. 9/8

1:29 pm-11:45 pm

1 stop10h 16m

$395

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

sáb. 9/13

7:03 pm-11:05 am

2 stops16h 02m

Santiago de los Caballeros

sáb. 9/20

12:10 pm-2:35 pm

1 stop26h 25m

$419

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

dom. 10/5

4:20 pm-12:50 pm

1 stop20h 30m

Santiago de los Caballeros

vie. 10/24

3:20 am-4:50 pm

1 stop13h 30m

$466

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

dom. 10/5

9:23 am-11:05 am

1 stop25h 42m

$145

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

lun. 9/1

8:00 am-8:48 pm

2 stops12h 48m

$181

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

mié. 9/17

10:00 am-7:11 pm

1 stop9h 11m

$205

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

mié. 9/17

5:14 pm-11:03 am

3 stops41h 49m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Best time to book a flight from Durham to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Durham with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Santiago de los Caballeros

How far ahead should I book a flight from Durham to Santiago de los Caballeros?

The best time to book flights from Durham to Santiago de los Caballeros is 29 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Durham to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Durham to Santiago de los Caballeros (average of $347). Flying from Durham to Santiago de los Caballeros in July is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to STI?

When flying from Durham to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santiago de los Caballeros

Get a feel of what it's like to fly with Delta, JetBlue, and American Airlines from Durham to Santiago de los Caballeros by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,981 reviews

Delta

8.0

Very good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

JetBlue

7.3

Good

2,914 reviews

Delta

8.0

Very good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Spirit Airlines

6.3

Okay

8,049 reviews

Delta

8.0

Very good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What airport do you fly into for flights to Santiago de los Caballeros from Durham?
Santiago de los Caballeros (STI) is the airport you will fly into if you book a flight from Durham to Santiago de los Caballeros. You should not have trouble finding flights to Santiago from Durham; the airport handles an average of 0 inbound flights from Durham per day. You should also have plenty of airline options to choose from since 4 airlines have flights to the Santiago de los Caballeros airport from Durham. It is only a 6.8 mi journey from Santiago (STI) to Santiago de los Caballeros’s city center.
What are the cheapest airlines to fly from Durham to Santiago de los Caballeros one-way?
To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $145. American Airlines flights start at $181 while deals on Delta start at $205 one-way.
Can I find deals for flights from Durham to Santiago de los Caballeros that include hotel bookings?
Yes. In addition to deals on Durham to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Durham to Santiago de los Caballeros?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Santiago de los Caballeros.
Can I find deals for business class flights from Durham to Santiago de los Caballeros?
Yes. Cheapflights offers flight deals from Durham to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Durham to Santiago de los Caballeros?
Currently, May is the cheapest month in which you can book a flight from Durham to Santiago de los Caballeros (average of $347). Flying from Durham to Santiago de los Caballeros in July is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from Durham to Santiago de los Caballeros

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$279	Average$452	FlexibilityNo cancel fee	On-timeN/A
JetBlue	Cheapest$391	Average$561	FlexibilityNo cancel fee	On-time62%
United Airlines	Cheapest$396	Average$617	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$442	Average$739	FlexibilityNo cancel fee	On-time71%

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$145+ Cheap flights from Durham, NC to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Durham to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Durham to Santiago de los Caballeros are usually found in September or March, booked 29 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Durham to Santiago de los Caballeros

Keep the following information in mind while searching for Durham to Santiago de los Caballeros flight deals. Data was last updated julio 31, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Durham to Santiago de los Caballeros

Cheapest flights from Durham to Santiago de los CaballerosExplore the most affordable flight options available from Durham to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 31, 2025.

Explore the most affordable flight options available from Durham to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 31, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Durham to Santiago de los Caballeros that are best for you.

Best time to book a flight from Durham to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Durham with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Durham to Santiago de los Caballeros

How far ahead should I book a flight from Durham to Santiago de los Caballeros?

Use this chart to determine the optimal time to book a round-trip flight from Durham to Santiago de los Caballeros. Price data was last updated on July 25, 2025.

What is the cheapest month to book a flight from Durham to Santiago de los Caballeros?

What is the cheapest time of day to fly from DU8 to STI?

Find hourly flight availability from Durham to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 31, 2025.

Reviews of airlines servicing Santiago de los Caballeros

Get a feel of what it's like to fly with Delta, JetBlue, and American Airlines from Durham to Santiago de los Caballeros by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Durham to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Santiago de los Caballeros from Durham?

What are the cheapest airlines to fly from Durham to Santiago de los Caballeros one-way?

Can I find deals for flights from Durham to Santiago de los Caballeros that include hotel bookings?

How can I find direct flights from Durham to Santiago de los Caballeros?

Can I find deals for business class flights from Durham to Santiago de los Caballeros?

What is the cheapest month to book a flight from Durham to Santiago de los Caballeros?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Durham to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Durham to Santiago de los Caballeros

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Cheapest flights from Durham to Santiago de los Caballeros
Explore the most affordable flight options available from Durham to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 31, 2025.