What are the cheapest airlines to fly from Durham to Santiago de los Caballeros one-way?

To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $176. Frontier flights start at $228 while deals on American Airlines start at $342 one-way.

What is the cheapest day to fly from Durham to Santiago de los Caballeros?

Travelers seeking maximum savings on their Durham to Santiago de los Caballeros flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Durham to Santiago de los Caballeros?

American Airlines, JetBlue and Delta are the most popular airlines when flying from Durham to Santiago de los Caballeros.

How far in advance should I book a flight from Durham to Santiago de los Caballeros?

Find a great deal and save up to 21% by booking at least 22 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Durham to Santiago de los Caballeros within the next two weeks, with the cheapest ticket starting at $442.

What is the cheapest month to fly from Durham to Santiago de los Caballeros?

The best pricing can be found in the month of September. Prices to Santiago de los Caballeros from Durham average $588. You can even find prices in September for less than $588, as users have found deals to Santiago de los Caballeros from as low as $353. The month of December appears to be one of the more expensive times to travel to Santiago de los Caballeros from Durham. Flying in the targeted month can save you up to 22%.

What airport do you fly into for flights to Santiago de los Caballeros from Durham?

Santiago de los Caballeros (STI) is the airport you will fly into if you book a flight from Durham to Santiago de los Caballeros. You should not have trouble finding flights to Santiago from Durham; the airport handles an average of 0 inbound flights from Durham per day. You should also have plenty of airline options to choose from since 4 airlines have flights to the Santiago de los Caballeros airport from Durham. It is only a 6.8 mi journey from Santiago (STI) to Santiago de los Caballeros’s city center.

How can I find direct flights from Durham to Santiago de los Caballeros?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Santiago de los Caballeros.

Can I find deals for business class flights from Durham to Santiago de los Caballeros?

Yes. Cheapflights offers flight deals from Durham to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$176+ Flights from Durham to Santiago de los Caballeros

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1. Tell us where you want to go

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We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Cheapflights Tip: The best prices from Durham to Santiago de los Caballeros are usually found in September or March, booked 86 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Durham to Santiago de los Caballeros

Round-trip from	$338 (SmartFares)
One-way from	$176 (Mytrip)
Popular in	December
Cheapest in	September
Average price	$618

From Durham to Santiago de los Caballeros

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One-way flight from Durham to Santiago de los Caballeros

Search Deals

Highest demand for flights based on searches. 1% potential increase in price ($6 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from Durham to Santiago de los Caballeros

Cheapest flights from Durham to Santiago de los Caballeros
Explore the most affordable flight options available from Durham to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Fri 9/58:43 pmRDU - STI

1 stop14h 41mSpirit Airlines

Fri 9/1212:19 pmSTI - RDU

1 stop7h 29mSpirit Airlines

Deal found 6/9

$338

Mon 7/289:10 amRDU - STI

1 stop24h 40mMultiple Airlines

Fri 8/82:06 pmSTI - RDU

1 stop6h 24mMultiple Airlines

Deal found 6/10

$425

Thu 11/66:00 amRDU - STI

1 stop13h 14mJetBlue

Wed 11/129:40 pmSTI - RDU

1 stop11h 06mJetBlue

Deal found 6/10

$433

Mon 9/112:06 pmRDU - STI

1 stop8h 42mAmerican Airlines

Mon 9/81:29 pmSTI - RDU

2 stops18h 44mAmerican Airlines

Deal found 6/11

$437

Thu 11/201:00 pmRDU - STI

2 stops11h 26mDelta

Sun 11/236:45 amSTI - RDU

1 stop8h 36mDelta

Deal found 6/12

$509

Thu 8/76:00 amRDU - STI

1 stop9h 12mUnited Airlines

Tue 8/122:07 pmSTI - RDU

1 stop8h 00mUnited Airlines

Deal found 6/9

$713

Best flights from Durham to Santiago de los Caballeros
Discover carefully curated flight deals from Durham to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Fri 9/58:43 pmRDU - STI

1 stop14h 41mSpirit Airlines

Fri 9/1212:19 pmSTI - RDU

1 stop7h 29mSpirit Airlines

Deal found 6/9

$338

Mon 7/289:10 amRDU - STI

1 stop24h 40mMultiple Airlines

Fri 8/82:06 pmSTI - RDU

1 stop6h 24mMultiple Airlines

Deal found 6/10

$425

Thu 11/66:00 amRDU - STI

1 stop13h 14mJetBlue

Wed 11/129:40 pmSTI - RDU

1 stop11h 06mJetBlue

Deal found 6/10

$433

Mon 9/112:06 pmRDU - STI

1 stop8h 42mAmerican Airlines

Mon 9/81:29 pmSTI - RDU

2 stops18h 44mAmerican Airlines

Deal found 6/11

$437

Thu 11/201:00 pmRDU - STI

2 stops11h 26mDelta

Sun 11/236:45 amSTI - RDU

1 stop8h 36mDelta

Deal found 6/12

$509

Thu 8/76:00 amRDU - STI

1 stop9h 12mUnited Airlines

Tue 8/122:07 pmSTI - RDU

1 stop8h 00mUnited Airlines

Deal found 6/9

$713

Last-minute flights from Durham to Santiago de los Caballeros
Discover last-minute flight deals from Durham to Santiago de los Caballeros. Data last updated June 12, 2025 and is based on user searches.

Tue 6/246:47 amRDU - STI

1 stop12h 47mJetBlue

Sun 6/298:59 pmSTI - RDU

1 stop11h 32mJetBlue

Deal found 6/10

$586

Sun 6/298:59 amRDU - STI

2 stops12h 06mAmerican Airlines

Mon 7/71:30 pmSTI - RDU

1 stop21h 37mAmerican Airlines

Deal found 6/11

$542

Thu 7/310:35 amRDU - STI

1 stop23h 54mSpirit Airlines

Sat 7/1210:55 amSTI - RDU

1 stop8h 48mSpirit Airlines

Deal found 6/11

$390

Mon 7/289:10 amRDU - STI

1 stop24h 40mMultiple Airlines

Fri 8/82:06 pmSTI - RDU

1 stop6h 24mMultiple Airlines

Deal found 6/10

$425

One-way flights from Durham to Santiago de los Caballeros
Search for one-way flight options from Durham to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Fri 8/19:10 amRDU - STI

1 stop24h 40mSpirit Airlines

Deal found 6/10

$176

Thu 6/1911:51 amRDU - STI

2 stops24h 59mFrontier

Deal found 6/11

$228

Fri 8/110:01 amRDU - STI

2 stops23h 49mMultiple Airlines

Deal found 6/10

$300

Fri 6/207:21 pmRDU - STI

1 stop17h 19mAmerican Airlines

Deal found 6/10

$342

Cheapflights Fare Finder

Use the filters below to find and compare flights from Durham to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

Fri 9/5

8:43 pm-11:24 am

1 stop14h 41m

Santiago de los Caballeros

Fri 9/12

12:19 pm-7:48 pm

1 stop7h 29m

$338

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

Mon 7/28

9:10 am-9:50 am

1 stop24h 40m

Santiago de los Caballeros

Fri 8/8

2:06 pm-8:30 pm

1 stop6h 24m

$425

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

Mon 9/1

12:06 pm-8:48 pm

1 stop8h 42m

Santiago de los Caballeros

Mon 9/8

1:29 pm-8:13 am

2 stops18h 44m

$437

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

Fri 9/5

11:17 am-6:03 pm

1 stop6h 46m

Santiago de los Caballeros

Thu 9/11

3:45 am-4:50 pm

1 stop13h 05m

$558

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

Thu 8/7

6:00 am-3:12 pm

1 stop9h 12m

Santiago de los Caballeros

Tue 8/12

2:07 pm-10:07 pm

1 stop8h 00m

$713

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

Fri 8/1

9:10 am-9:50 am

1 stop24h 40m

$176

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

Thu 6/19

11:51 am-12:50 pm

2 stops24h 59m

$228

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

Fri 8/1

10:01 am-9:50 am

2 stops23h 49m

$300

RaleighSantiago de los Caballeros

RDU - STI

RDUSTI

Raleigh-Durham

Fri 6/20

7:21 pm-12:40 pm

1 stop17h 19m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Durham to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Durham with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Santiago de los Caballeros

How far ahead should I book a flight from Durham to Santiago de los Caballeros?

The best time to book flights from Durham to Santiago de los Caballeros is 86 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Durham to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Durham to Santiago de los Caballeros (average of $347). Flying from Durham to Santiago de los Caballeros in July is currently the most expensive (average of $630). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to STI?

When flying from Durham to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Santiago de los Caballeros by month

In terms of precipitation, rainfall in Santiago de los Caballeros ranges from 3.0 - 11.6 inches per month. December is typically the wettest month, when rainfall can reach 11.6 in. July is typically the driest time to visit Santiago de los Caballeros when rainfall is around 3.0 in.

Temperature in Santiago de los Caballeros by month

If weather is an important factor for your trip to Santiago de los Caballeros, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

Reviews of airlines servicing Santiago de los Caballeros

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,946 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,790 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

JetBlue

7.3

Good

2,925 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Spirit Airlines

6.3

Okay

8,052 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What airport do you fly into for flights to Santiago de los Caballeros from Durham?
Santiago de los Caballeros (STI) is the airport you will fly into if you book a flight from Durham to Santiago de los Caballeros. You should not have trouble finding flights to Santiago from Durham; the airport handles an average of 0 inbound flights from Durham per day. You should also have plenty of airline options to choose from since 4 airlines have flights to the Santiago de los Caballeros airport from Durham. It is only a 6.8 mi journey from Santiago (STI) to Santiago de los Caballeros’s city center.
What are the cheapest airlines to fly from Durham to Santiago de los Caballeros one-way?
To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $176. Frontier flights start at $228 while deals on American Airlines start at $342 one-way.
Can I find deals for flights from Durham to Santiago de los Caballeros that include hotel bookings?
Yes. In addition to deals on Durham to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Durham to Santiago de los Caballeros?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Santiago de los Caballeros.
Can I find deals for business class flights from Durham to Santiago de los Caballeros?
Yes. Cheapflights offers flight deals from Durham to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Durham to Santiago de los Caballeros?
Currently, May is the cheapest month in which you can book a flight from Durham to Santiago de los Caballeros (average of $347). Flying from Durham to Santiago de los Caballeros in July is currently the most expensive (average of $630). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from Durham to Santiago de los Caballeros

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$353	Average$452	FlexibilityNo cancel fee	On-timeN/A
JetBlue	Cheapest$391	Average$556	FlexibilityNo cancel fee	On-time62%
United Airlines	Cheapest$396	Average$617	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$444	Average$638	FlexibilityNo cancel fee	On-time71%

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$176+ Cheap flights from Durham, NC to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Durham to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Durham to Santiago de los Caballeros are usually found in September or March, booked 86 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Durham to Santiago de los Caballeros

Keep the following information in mind while searching for Durham to Santiago de los Caballeros flight deals. Data was last updated June 12, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Durham to Santiago de los Caballeros

Cheapest flights from Durham to Santiago de los CaballerosExplore the most affordable flight options available from Durham to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from Durham to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Durham to Santiago de los Caballeros that are best for you.

Best time to book a flight from Durham to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Durham with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Durham to Santiago de los Caballeros

How far ahead should I book a flight from Durham to Santiago de los Caballeros?

Use this chart to determine the optimal time to book a round-trip flight from Durham to Santiago de los Caballeros. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from Durham to Santiago de los Caballeros?

What is the cheapest time of day to fly from DU8 to STI?

Find hourly flight availability from Durham to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Rainfall in Santiago de los Caballeros by month

Plan your trip to Santiago de los Caballeros by taking into account the average rainfall totals by month.

Temperature in Santiago de los Caballeros by month

Plan your trip to Santiago de los Caballeros by taking into account the average temperature totals by month.

Reviews of airlines servicing Santiago de los Caballeros

Related info for your journey

Find useful and relevant information for your journey from Durham to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Santiago de los Caballeros from Durham?

What are the cheapest airlines to fly from Durham to Santiago de los Caballeros one-way?

Can I find deals for flights from Durham to Santiago de los Caballeros that include hotel bookings?

How can I find direct flights from Durham to Santiago de los Caballeros?

Can I find deals for business class flights from Durham to Santiago de los Caballeros?

What is the cheapest month to book a flight from Durham to Santiago de los Caballeros?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Durham to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Durham to Santiago de los Caballeros

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Cheapest flights from Durham to Santiago de los Caballeros
Explore the most affordable flight options available from Durham to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.