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$351+ Cheap flights from Santo Domingo (SDQ) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/11. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SCL
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
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Cheap flight deals from Santo Domingo to Santiago

Cheapest flights from Santo Domingo to Santiago
Explore the most affordable flight options available from Santo Domingo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

This Copa Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/272:14 pmSDQ - SCL
1 stop12h 29mCopa Airlines
Mon 2/2312:28 pmSCL - SDQ
1 stop14h 49mCopa Airlines
Deal found 12/27$717
This Copa Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:55 amSDQ - SCL
1 stop14h 29mCopa Airlines
Sat 1/1012:28 pmSCL - SDQ
1 stop11h 27mCopa Airlines
Deal found 12/26$904
This Copa Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:39 pmSDQ - SCL
1 stop10h 22mCopa Airlines
Sat 1/1712:28 pmSCL - SDQ
1 stop11h 27mCopa Airlines
Deal found 12/27$927
This FlightHub deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:55 amSDQ - SCL
1 stop13h 46mMultiple Airlines
Sat 1/105:10 amSCL - SDQ
2 stops36h 40mMultiple Airlines
Deal found 12/26$1,017
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:57 pmSDQ - SCL
2 stops22h 18mDelta
Thu 2/511:10 pmSCL - SDQ
2 stops26h 20mDelta
Deal found 12/26$3,136
This Delta deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/273:57 pmSDQ - SCL
1 stop14h 43mDelta
Sat 1/1711:10 pmSCL - SDQ
2 stops26h 20mDelta
Deal found 12/27$3,236
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2711:07 amSDQ - SCL
2 stops19h 38mAmerican Airlines
Sat 1/1010:30 pmSCL - SDQ
2 stops18h 13mAmerican Airlines
Deal found 12/26$5,036

Find flight deals from Santo Domingo to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$679
(Avianca)

One-way from

$351
(Copa Airlines)

Popular in

February

Cheapest in

October

Average price

$759
Provider with most accurate pricing for Santo Domingo Las Americas-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Santiago Arturo Merino Benitez flights.
Search Deals
From Santo Domingo Las Americas to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Santo Domingo Las Americas to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($77 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Santo Domingo to Santiago that are best for you.

Fly from

Santo Domingo

Fly to

Santiago

Route

Depart

Return

Price

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Thu 4/16

6:10 pm-4:15 am

1 stop10h 05m

Santiago Arturo Merino Benitez

Sat 5/2

6:10 am-5:15 pm

1 stop11h 05m

$679

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Wed 3/25

2:13 pm-6:00 am

1 stop14h 47m

Santiago Arturo Merino Benitez

Tue 4/7

12:09 am-11:41 am

1 stop11h 32m

$717

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Fri 3/20

8:48 am-11:49 pm

1 stop14h 01m

Santiago Arturo Merino Benitez

Mon 3/23

5:21 am-4:14 pm

1 stop11h 53m

$717

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Thu 1/22

12:40 pm-11:43 pm

1 stop10h 03m

Santiago Arturo Merino Benitez

Wed 1/28

5:44 am-10:55 pm

1 stop18h 11m

$764

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Sat 1/17

8:50 am-11:43 pm

1 stop13h 53m

Santiago Arturo Merino Benitez

Sat 1/24

12:28 pm-2:17 am

1 stop14h 49m

$764

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Thu 4/16

6:10 pm-4:15 am

1 stop10h 05m

Santiago Arturo Merino Benitez

Sat 5/2

11:55 pm-1:13 pm

2 stops13h 18m

$1,332

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Mon 1/19

6:00 am-8:50 am

2 stops25h 50m

Santiago Arturo Merino Benitez

Mon 1/26

10:45 pm-11:46 pm

2 stops26h 01m

$2,163

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Tue 1/13

6:00 am-8:50 am

2 stops25h 50m

Santiago Arturo Merino Benitez

Tue 1/20

10:45 pm-11:46 pm

2 stops26h 01m

$2,487

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Mon 1/19

3:46 pm-5:20 pm

2 stops24h 34m

Santiago Arturo Merino Benitez

Mon 1/26

11:10 pm-7:14 pm

2 stops21h 04m

$2,671

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Sun 1/11

8:50 am-8:20 pm

1 stop10h 30m

$351

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/26

Showing 1-10 of 14 results
1
2

Compare providers for flights from Santo Domingo to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Santiago in December.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santo Domingo-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Santiago

How far ahead should I book a flight from Santo Domingo to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Santiago. Price data was last updated on December 26, 2025.

The best time to book flights from Santo Domingo to Santiago is 67 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Santiago?

Currently, September is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of $241). Flying from Santo Domingo to Santiago in January is currently the most expensive (average of $373). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated December 28, 2025.
Get a feel of what it's like to fly with Copa Airlines and Avianca from Santo Domingo to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Crew

8.1

Food

6.8

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Crew

8.1

Food

6.8

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Avianca
6.6
Okay
2,489 reviews
Copa Airlines
7.6
Good
1,561 reviews

Crew

8.1

Food

6.8

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Santiago?

    There are many flights that can get you from Santo Domingo to Santiago in 10h 05m. Fly via Avianca or Copa Airlines to get the fastest option. The distance between Santo Domingo and Santiago is about 3579 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Santo Domingo to Santiago round-trip?

    According to our current data, Copa Airlines ($281), and Avianca ($321) offers the cheapest pricing from Santo Domingo to Santiago. Copa Airlines is 55% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Santo Domingo to Santiago that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Santiago.

  • Can I find deals for business class flights from Santo Domingo to Santiago?

    Yes. Cheapflights offers flight deals from Santo Domingo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Santiago?

    Currently, September is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of $241). Flying from Santo Domingo to Santiago in January is currently the most expensive (average of $373). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Punta Cana to Santiago flights

Top 2 airlines flying from Santo Domingo to Santiago

Discover the top 2 airlines that operate flights from Santo Domingo to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$465Average$606FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$467Average$740FlexibilityNo cancel feeOn-time70%

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