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$190+ Cheap flights from Santo Domingo (SDQ) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SCL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Santo Domingo Las Americas to Santiago Arturo Merino Benitez are usually found in October or November, booked 67 days in advance, depart on a Monday or Tuesday and return on a Monday

Cheap flight deals from Santo Domingo to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$577
(Booking.com)

One-way from

$190
(Arajet)

Popular in

February

Cheapest in

October

Average price

$585
From Santo Domingo Las Americas to Santiago Arturo Merino Benitez
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One-way flight from Santo Domingo Las Americas to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 13% potential increase in price ($98 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santo Domingo to Santiago

Cheapest flights from Santo Domingo to Santiago
Explore the most affordable flight options available from Santo Domingo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/119:00 pmSDQ - SCL
1 stop16h 45mMultiple Airlines
Tue 9/2310:40 pmSCL - SDQ
1 stop11h 35mMultiple Airlines
Deal found 9/10$548
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/149:30 pmSDQ - SCL
1 stop16h 15mMultiple Airlines
Tue 9/2310:40 pmSCL - SDQ
1 stop11h 35mMultiple Airlines
Deal found 9/10$552
This Booking.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:45 pmSDQ - SCL
1 stop10h 45mMultiple Airlines
Mon 11/106:00 amSCL - SDQ
1 stop11h 45mMultiple Airlines
Deal found 9/10$577
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/119:00 pmSDQ - SCL
1 stop16h 45mMultiple Airlines
Wed 9/244:35 amSCL - SDQ
1 stop11h 50mMultiple Airlines
Deal found 9/10$590
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/119:00 pmSDQ - SCL
1 stop16h 45mMultiple Airlines
Thu 9/255:51 amSCL - SDQ
1 stop27h 54mMultiple Airlines
Deal found 9/10$597
This Priceline deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:10 pmSDQ - SCL
1 stop10h 05mAvianca
Wed 9/247:10 amSCL - SDQ
1 stop11h 05mAvianca
Deal found 9/10$605
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/149:30 pmSDQ - SCL
1 stop16h 15mMultiple Airlines
Thu 9/255:51 amSCL - SDQ
1 stop27h 54mMultiple Airlines
Deal found 9/10$607
This Priceline deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:45 pmSDQ - SCL
1 stop10h 45mAvianca
Sun 11/91:35 amSCL - SDQ
1 stop16h 15mAvianca
Deal found 9/10$608
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/149:30 pmSDQ - SCL
1 stop16h 15mMultiple Airlines
Wed 9/244:35 amSCL - SDQ
1 stop11h 50mMultiple Airlines
Deal found 9/10$609
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:10 pmSDQ - SCL
1 stop10h 05mMultiple Airlines
Tue 9/2310:40 pmSCL - SDQ
1 stop11h 35mMultiple Airlines
Deal found 9/10$611
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:10 pmSDQ - SCL
1 stop10h 05mMultiple Airlines
Wed 9/244:35 amSCL - SDQ
1 stop11h 50mMultiple Airlines
Deal found 9/10$613

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Santo Domingo to Santiago that are best for you.

Fly from

Santo Domingo

Fly to

Santiago

Route

Depart

Return

Price

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Sun 12/14

8:50 pm-5:14 am

1 stop31h 24m

Santiago Arturo Merino Benitez

Mon 12/29

6:00 am-4:45 pm

1 stop11h 45m

$625

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Sat 10/4

11:45 am-11:30 pm

1 stop10h 45m

Santiago Arturo Merino Benitez

Tue 10/7

12:55 am-5:15 pm

1 stop17h 20m

$677

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Wed 9/24

6:10 pm-5:15 am

1 stop10h 05m

Santiago Arturo Merino Benitez

Sun 9/28

7:10 am-5:15 pm

1 stop11h 05m

$677

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Fri 10/10

11:57 am-12:04 am

1 stop11h 07m

Santiago Arturo Merino Benitez

Fri 10/10

3:35 am-10:25 pm

1 stop19h 50m

$679

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Sun 10/5

11:57 am-11:40 pm

1 stop10h 43m

Santiago Arturo Merino Benitez

Fri 10/31

12:20 pm-10:25 pm

1 stop11h 05m

$679

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Sun 3/8

8:48 am-11:49 pm

1 stop14h 01m

Santiago Arturo Merino Benitez

Wed 3/18

5:44 am-4:14 pm

1 stop11h 30m

$682

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Wed 11/5

8:55 am-8:21 pm

1 stop10h 26m

Santiago Arturo Merino Benitez

Fri 11/7

3:23 am-4:15 pm

1 stop13h 52m

$682

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Sun 11/2

8:55 am-3:43 am

1 stop17h 48m

Santiago Arturo Merino Benitez

Fri 11/14

3:23 am-4:15 pm

1 stop13h 52m

$682

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Sun 9/28

1:55 pm-3:35 am

1 stop12h 40m

$190

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Tue 10/14

2:25 pm-3:35 am

1 stop12h 10m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 16 results
1
2

Best time to book a flight from Santo Domingo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Santiago

How far ahead should I book a flight from Santo Domingo to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Santiago. Price data was last updated on August 29, 2025.

The best time to book flights from Santo Domingo to Santiago is 67 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Santiago?

Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of $752). Flying from Santo Domingo to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to SCL?

Find hourly flight availability from Santo Domingo to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

A simple way to save on the total cost of your ticket is to fly from Santo Domingo to Santiago at noon. If you’re flexible enough to do this you can expect to save up to 16% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with Copa Airlines and Avianca from Santo Domingo to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Food

6.8

Overall

7.6

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

PEI - PTY

The attention to us was excellent. Help was provided with care.
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Food

6.8

Overall

7.6

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

PEI - PTY

The attention to us was excellent. Help was provided with care.
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Food

6.8

Overall

7.6

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

PEI - PTY

The attention to us was excellent. Help was provided with care.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Santiago?

    There are many flights that can get you from Santo Domingo to Santiago in 10h 45m. Fly via Avianca or Copa Airlines to get the fastest option. The distance between Santo Domingo and Santiago is about 3579 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Santo Domingo to Santiago round-trip?

    According to our current data, Copa Airlines ($467), and Avianca ($511) offers the cheapest pricing from Santo Domingo to Santiago. Copa Airlines is 25% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Santo Domingo to Santiago that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Santiago.

  • Can I find deals for business class flights from Santo Domingo to Santiago?

    Yes. Cheapflights offers flight deals from Santo Domingo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of $752). Flying from Santo Domingo to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Punta Cana to Santiago flights

Top 2 airlines flying from Santo Domingo to Santiago

Discover the top 2 airlines that operate flights from Santo Domingo to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$467Average$661FlexibilityNo cancel feeOn-time70%
AviancaCheapest$511Average$588FlexibilityNo cancel feeOn-time71%

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