$280+ Cheap flights from Santiago (SCL) to Santo Domingo (SDQ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SDQ
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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Find cheap flights from Santiago to Santo Domingo with Cheapflights
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Cheapest flights from Santiago to Santo DomingoExplore the most affordable flight options available from Santiago to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Santiago to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:32 pm -
1 stop19h 38m
Wed 12/168:05 pm -
1 stop31h 58m
Deal found 9/12![Multiple Airlines logo]()
$498
This Trip.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:07 am -
1 stop27h 33m
Thu 12/318:50 pm -
1 stop12h 33m
Deal found 9/13![Multiple Airlines logo]()
$534
This Trip.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:00 am -
1 stop27h 41m
Sun 11/2210:21 pm -
1 stop30h 04m
Deal found 9/14![Multiple Airlines logo]()
$548
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:00 am -
1 stop27h 41m
Sun 12/1310:21 pm -
1 stop29h 42m
Deal found 9/14![Multiple Airlines logo]()
$549
This Avianca deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/121:30 am -
1 stop17h 25m
Sun 10/1812:45 pm -
1 stop16h 00m
Deal found 9/16![Avianca logo]()
$551
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:00 am -
1 stop25h 10m
Wed 12/28:05 pm -
1 stop15h 35m
Deal found 9/15![Multiple Airlines logo]()
$555
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/113:15 am -
1 stop10h 57m
Mon 10/1912:42 pm -
1 stop9h 57m
Deal found 9/15![Copa Airlines logo]()
$556
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:15 am -
1 stop10h 57m
Thu 10/812:42 pm -
1 stop9h 57m
Deal found 9/14![Copa Airlines logo]()
$558
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:43 am -
1 stop10h 59m
Fri 10/212:42 pm -
1 stop9h 57m
Deal found 9/15![Copa Airlines logo]()
$560
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:07 am -
1 stop27h 33m
Thu 1/78:50 pm -
1 stop13h 03m
Deal found 9/13![Multiple Airlines logo]()
$566
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:23 pm -
1 stop15h 02m
Sat 10/1712:12 pm -
1 stop31h 20m
Deal found 9/15![Copa Airlines logo]()
$569
Best flights from Santiago to Santo DomingoDiscover carefully curated flight deals from Santiago to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Santiago to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:15 pm -
1 stop11h 43m
Sun 11/225:55 am -
1 stop20h 43m
Deal found 9/13![Copa Airlines logo]()
$574
This Arajet deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/139:25 am -
1 stop13h 15m
Sat 2/201:40 pm -
1 stop12h 10m
Deal found 9/11![Multiple Airlines logo]()
$697
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/33:48 am -
1 stop20h 10m
Fri 12/118:55 am -
1 stop16h 53m
Deal found 9/11![Copa Airlines logo]()
$574
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:07 am -
1 stop18h 51m
Sat 12/127:03 pm -
1 stop24h 08m
Deal found 9/11![Copa Airlines logo]()
$637
This Arajet deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/29:25 am -
1 stop13h 15m
Sat 1/91:40 pm -
1 stop12h 10m
Deal found 9/13![Multiple Airlines logo]()
$729
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:07 am -
1 stop18h 51m
Tue 1/512:06 pm -
1 stop11h 17m
Deal found 9/14![Copa Airlines logo]()
$637
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/71:16 am -
1 stop22h 06m
Mon 3/158:40 am -
1 stop16h 42m
Deal found 9/11![Copa Airlines logo]()
$700
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/131:16 am -
1 stop13h 13m
Sun 3/215:54 am -
1 stop23h 22m
Deal found 9/15![Copa Airlines logo]()
$720
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:07 am -
1 stop22h 01m
Sat 12/2612:43 pm -
1 stop10h 35m
Deal found 9/13![Copa Airlines logo]()
$723
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/143:19 am -
1 stop10h 55m
Tue 12/157:03 pm -
1 stop9h 49m
Deal found 9/13![Copa Airlines logo]()
$723
Last-minute flights from Santiago to Santo DomingoDiscover last-minute flight deals from Santiago to Santo Domingo. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to Santo Domingo. Data last updated September 17, 2026 and is based on user searches.
This FlightHub deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/214:20 pm -
1 stop26h 35m
Mon 9/286:50 pm -
1 stop28h 30m
Deal found 9/13![Avianca logo]()
$594
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:40 am -
1 stop11h 15m
Wed 9/3012:45 pm -
1 stop16h 00m
Deal found 9/15![Avianca logo]()
$571
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:43 am -
1 stop10h 59m
Fri 10/212:42 pm -
1 stop9h 57m
Deal found 9/15![Copa Airlines logo]()
$560
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2712:22 pm -
1 stop24h 20m
Sun 10/412:42 pm -
1 stop9h 57m
Deal found 9/13![Copa Airlines logo]()
$573
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:22 pm -
1 stop28h 53m
Sun 10/46:06 am -
1 stop17h 16m
Deal found 9/16![Copa Airlines logo]()
$574
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:15 am -
1 stop10h 57m
Thu 10/812:42 pm -
1 stop9h 57m
Deal found 9/14![Copa Airlines logo]()
$558
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:15 am -
1 stop10h 57m
Fri 10/92:16 pm -
1 stop11h 30m
Deal found 9/11![Copa Airlines logo]()
$581
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:40 am -
1 stop11h 15m
Fri 10/1612:45 pm -
1 stop16h 00m
Deal found 9/14![Avianca logo]()
$578
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:23 pm -
1 stop15h 02m
Sat 10/1712:12 pm -
1 stop31h 20m
Deal found 9/15![Copa Airlines logo]()
$569
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/113:15 am -
1 stop10h 57m
Mon 10/1912:42 pm -
1 stop9h 57m
Deal found 9/15![Copa Airlines logo]()
$556
This Avianca deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/121:30 am -
1 stop17h 25m
Sun 10/1812:45 pm -
1 stop16h 00m
Deal found 9/16![Avianca logo]()
$551
One-way flights from Santiago to Santo DomingoSearch for one-way flight options from Santiago to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from Santiago to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2712:32 pm -
1 stop19h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$280
This Arajet deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:25 am -
1 stop13h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$283
This Mytrip deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/241:30 pm -
1 stop18h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$286
This Arajet deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:00 am -
1 stop11h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$289
This Arajet deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:00 am -
1 stop11h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/76:07 am -
1 stop28h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/2610:12 pm -
1 stop33h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1210:12 pm -
1 stop33h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$298
This Arajet deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2810:00 am -
1 stop12h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/39:02 pm -
1 stop11h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:58 am -
1 stop27h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$312
This Arajet deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:00 am -
1 stop11h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$317
Find flight deals from Santiago to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $498 (Kiwi.com) |
One-way from | $280 (Kiwi.com) |
Popular in | January |
Cheapest in | October |
Average price | $646 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Santiago to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Mon 3/8
6:00 am-4:45 pm
1 stop11h 45m
Santo Domingo Las Americas
Wed 12/31
12:00 am-1:30 am
Nonstop0h 00m
$304
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Sat 1/23
9:25 am-9:40 pm
1 stop13h 15m
Santo Domingo Las Americas
Wed 12/31
12:00 am-1:30 am
Nonstop0h 00m
$337
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Fri 2/5
5:00 am-4:20 pm
1 stop12h 20m
Santo Domingo Las Americas
Wed 12/31
12:00 am-1:30 am
Nonstop0h 00m
$337
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Wed 9/30
5:14 am-10:56 pm
1 stop18h 42m
Santo Domingo Las Americas
Wed 12/31
12:00 am-1:30 am
Nonstop0h 00m
$353
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Mon 10/5
1:07 am-1:12 pm
1 stop13h 05m
Santo Domingo Las Americas
Wed 12/31
12:00 am-1:30 am
Nonstop0h 00m
$353
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Sun 11/15
12:15 pm-1:10 pm
1 stop25h 55m
Santo Domingo Las Americas
Wed 12/31
12:00 am-1:30 am
Nonstop0h 00m
$353
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Mon 9/28
5:14 am-10:56 pm
1 stop18h 42m
Santo Domingo Las Americas
Wed 12/31
12:00 am-1:30 am
Nonstop0h 00m
$353
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Sun 11/15
12:15 pm-10:58 pm
1 stop11h 43m
Santo Domingo Las Americas
Sun 11/22
5:55 am-3:38 am
1 stop20h 43m
$574
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Thu 12/3
3:48 am-10:58 pm
1 stop20h 10m
Santo Domingo Las Americas
Fri 12/11
8:55 am-2:48 am
1 stop16h 53m
$574
SantiagoSanto Domingo
SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas
SCLSDQ
Santiago Arturo Merino Benitez
Sat 12/5
5:07 am-10:58 pm
1 stop18h 51m
Santo Domingo Las Americas
Sat 12/12
7:03 pm-8:11 pm
1 stop24h 08m
$637
Showing 1-10 of 17 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Santiago-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Santiago with our price prediction graph.
SCL-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to Santo Domingo
How far ahead should I book a flight from Santiago to Santo Domingo?
Booking 41 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santiago to Santo Domingo. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Santiago to Santo Domingo?
Currently, October is the cheapest month in which you can book a flight from Santiago to Santo Domingo (average of $547). Flying from Santiago to Santo Domingo in January is currently the most expensive (average of $706). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santiago to Santo Domingo?
Airfare is below average for this route at the moment.
Santiago to Santo Domingo flights typically cost between $596 and $692 in December.The cheapest round-trip price found within the last 5 days was $498 on Multiple Airlines (Dec 9-Dec 16).
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated September 17, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Santiago to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Entertainment
6.9
Food
6.9
Overall
7.6
Crew
8.1
Comfort
7.4
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Boarding
7.8
Entertainment
6.9
Food
6.9
Overall
7.6
Crew
8.1
Comfort
7.4
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Boarding
7.8
Entertainment
6.9
Food
6.9
Overall
7.6
Crew
8.1
Comfort
7.4
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Related info for your journey
Find useful and relevant information for your journey from Santiago to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
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Santiago and Santo Domingo flights
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Top 2 airlines flying from Santiago to Santo Domingo
Discover the top 2 airlines that operate flights from Santiago to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$517 | Average$618 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$536 | Average$886 | FlexibilityNo cancel fee | On-time71% |