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$216+ Cheap flights from Quito (UIO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
UIO — SCL
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Cheapflights Tip: The best prices from Quito Mariscal Sucr to Santiago Arturo Merino Benitez are usually found in April or June, booked 32 days in advance, depart on a Monday or Friday and return on a Friday

Find flight deals from Quito to Santiago

Cheapest flights from Quito to Santiago
Explore the most affordable flight options available from Quito to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Priceline deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:30 amUIO - SCL
2 stops21h 00mAvianca
Sun 3/11:35 amSCL - UIO
1 stop13h 35mAvianca
Deal found 11/11$446
This CheapOair deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:49 pmUIO - SCL
1 stop10h 25mJetSMART
Sun 1/115:59 amSCL - UIO
1 stop12h 01mJetSMART
Deal found 11/11$451
This CheapOair deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/268:20 pmUIO - SCL
1 stop15h 45mMultiple Airlines
Sun 1/115:59 amSCL - UIO
1 stop11h 56mMultiple Airlines
Deal found 11/13$457
This Mytrip deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/296:30 amUIO - SCL
2 stops16h 00mAvianca
Sat 12/67:25 amSCL - UIO
1 stop19h 55mAvianca
Deal found 11/13$465
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/173:55 pmUIO - SCL
2 stops21h 25mAvianca
Wed 11/264:25 pmSCL - UIO
1 stop22h 45mAvianca
Deal found 11/10$470
This Priceline deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/164:40 pmUIO - SCL
2 stops20h 40mAvianca
Wed 11/191:35 amSCL - UIO
1 stop18h 20mAvianca
Deal found 11/12$473
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:34 pmUIO - SCL
1 stop30h 50mCopa Airlines
Wed 11/265:24 amSCL - UIO
1 stop9h 27mCopa Airlines
Deal found 11/10$479
This Mytrip deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/212:45 pmUIO - SCL
1 stop6h 50mMultiple Airlines
Sat 11/224:25 pmSCL - UIO
1 stop10h 55mMultiple Airlines
Deal found 11/11$481

Cheap flight deals from Quito to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Quito (UIO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$378
(JetSMART)

One-way from

$216
(JetSMART)

Popular in

February

Cheapest in

April

Average price

$406
Provider with most accurate pricing for Quito Mariscal Sucr-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Quito Mariscal Sucr-Santiago Arturo Merino Benitez flights.
Search Deals
From Quito Mariscal Sucr to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Quito Mariscal Sucr to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Quito

Fly to

Santiago

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 1/23

4:49 pm-8:44 pm

1 stop25h 55m

Santiago Arturo Merino Benitez

Tue 2/10

9:29 pm-4:00 pm

1 stop20h 31m

$429

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Thu 12/4

6:30 am-12:30 am

2 stops16h 00m

Santiago Arturo Merino Benitez

Mon 3/2

4:25 pm-7:25 am

2 stops17h 00m

$464

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sat 11/29

6:30 am-12:30 am

2 stops16h 00m

Santiago Arturo Merino Benitez

Sat 12/6

7:25 am-1:20 am

1 stop19h 55m

$465

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 11/16

4:40 pm-3:20 pm

2 stops20h 40m

Santiago Arturo Merino Benitez

Wed 11/19

1:35 am-5:55 pm

1 stop18h 20m

$473

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 12/10

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

Wed 12/17

7:25 am-1:20 am

1 stop19h 55m

$481

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 11/16

6:34 pm-11:41 pm

1 stop27h 07m

Santiago Arturo Merino Benitez

Fri 11/21

5:24 am-12:51 pm

1 stop9h 27m

$494

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 12/10

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

Fri 12/12

12:45 am-8:24 am

1 stop9h 39m

$497

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Mon 11/17

3:55 pm-3:20 pm

2 stops21h 25m

Santiago Arturo Merino Benitez

Tue 11/25

1:35 am-1:10 pm

1 stop13h 35m

$498

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Mon 11/17

12:27 pm-3:24 am

1 stop12h 57m

Santiago Arturo Merino Benitez

Wed 11/26

5:12 am-12:51 pm

1 stop9h 39m

$500

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 12/14

4:49 pm-5:14 am

1 stop10h 25m

$216

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 16 results
1
2

Compare providers for flights from Quito to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Quito to Santiago in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Quito-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Quito-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Quito-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Quito-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Quito-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Quito to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Quito with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Quito to Santiago

How far ahead should I book a flight from Quito to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Quito to Santiago. Price data was last updated on November 7, 2025.

The price you pay for your flight from Quito to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 32 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Quito to Santiago?

Currently, March is the cheapest month in which you can book a flight from Quito to Santiago (average of $116). Flying from Quito to Santiago in December is currently the most expensive (average of $171). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from UIO to SCL?

Find hourly flight availability from Quito to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 8% on flights from Quito to Santiago by exploring options for tickets at noon.

What is the cheapest day to fly from Quito to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Quito to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Quito to Santiago flight should consider departing on Monday at noon when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated November 13, 2025.
Read reviews from past customers who have flown Copa Airlines, LATAM Airlines, and Avianca from Quito to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,565 reviews

Crew

8.1

Overall

7.6

Food

6.9

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,565 reviews
Copa Airlines
7.6
Good
1,565 reviews

Crew

8.1

Overall

7.6

Food

6.9

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
LATAM Airlines
7.5
Good
1,875 reviews
Copa Airlines
7.6
Good
1,565 reviews

Crew

8.1

Overall

7.6

Food

6.9

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,475 reviews
Copa Airlines
7.6
Good
1,565 reviews

Crew

8.1

Overall

7.6

Food

6.9

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
JetSMART
6.6
Okay
240 reviews
Copa Airlines
7.6
Good
1,565 reviews

Crew

8.1

Overall

7.6

Food

6.9

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Quito to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Quito to Santiago?

    JetSMART and Avianca can get you from Quito to Santiago in just under 16h. Your travel time can differ by up to 9h 55m. There are 2349 mi between Quito and Santiago. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Quito to Santiago round-trip?

    Currently priced at $161, JetSMART will fly you from Quito to Santiago and back. In addition to JetSMART, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Copa Airlines and Avianca - these airlines can fly you to your destination from $183 and $207, respectively. JetSMART is priced at 57% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Quito to Santiago that include hotel bookings?

    Yes. In addition to deals on Quito to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Quito to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Quito to Santiago.

  • Can I find deals for business class flights from Quito to Santiago?

    Yes. Cheapflights offers flight deals from Quito to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Quito to Santiago?

    Currently, March is the cheapest month in which you can book a flight from Quito to Santiago (average of $116). Flying from Quito to Santiago in December is currently the most expensive (average of $171). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Quito to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Guayaquil to Santiago flights

Top 4 airlines flying from Quito to Santiago

Discover the top 4 airlines that operate flights from Quito to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetSMARTCheapest$161Average$372FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$183Average$507FlexibilityNo cancel feeOn-time70%
AviancaCheapest$207Average$423FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$360Average$525FlexibilityNo cancel feeOn-time81%

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