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$220+ Cheap flights from Quito (UIO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/20. Fares are subject to change and may not be available on all flights or dates of travel.
UIO — SCL
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
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Cheap flight deals from Quito to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Quito (UIO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$397
(JetSMART)

One-way from

$220
(JetSMART)

Popular in

February

Cheapest in

April

Average price

$431
Provider with most accurate pricing for Quito Mariscal Sucr-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Quito Mariscal Sucr-Santiago Arturo Merino Benitez flights.
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From Quito Mariscal Sucr to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Quito Mariscal Sucr to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 11% potential increase in price ($50 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Quito to Santiago

Cheapest flights from Quito to Santiago
Explore the most affordable flight options available from Quito to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This JetSMART deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Sun 5/314:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 1/15$363
This JetSMART deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Sun 5/104:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 1/15$384
This JetSMART deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Fri 5/224:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 1/14$387
This JetSMART deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Sun 4/124:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 1/15$393
This JetSMART deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/274:49 pm
UIO
-
SCL
1 stop15h 50m
JetSMART
Sun 3/295:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 1/15$397
This JetSMART deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/54:49 pm
UIO
-
SCL
1 stop10h 25m
JetSMART
Sun 7/194:59 am
SCL
-
UIO
1 stop12h 01m
JetSMART
Deal found 1/14$402
This CheapOair deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/104:49 pm
UIO
-
SCL
1 stop10h 27m
JetSMART
Fri 7/104:59 am
SCL
-
UIO
1 stop12h 01m
JetSMART
Deal found 1/14$403
This CheapOair deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/154:49 pm
UIO
-
SCL
1 stop15h 50m
JetSMART
Wed 3/255:59 am
SCL
-
UIO
1 stop12h 01m
JetSMART
Deal found 1/15$407
This JetSMART deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/224:49 pm
UIO
-
SCL
1 stop10h 25m
JetSMART
Fri 5/154:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 1/15$408
This Booking.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/224:49 pm
UIO
-
SCL
1 stop15h 50m
Multiple Airlines
Sun 3/2910:10 pm
SCL
-
UIO
1 stop15h 00m
Multiple Airlines
Deal found 1/14$410
This JetSMART deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/254:49 pm
UIO
-
SCL
1 stop15h 50m
JetSMART
Wed 4/15:41 am
SCL
-
UIO
1 stop12h 23m
JetSMART
Deal found 1/15$421

Cheapflights Fare Finder

 
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Quito

Fly to

Santiago

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 5/15

4:49 pm-4:11 am

1 stop10h 22m

Santiago Arturo Merino Benitez

Sun 5/31

4:56 am-4:04 pm

1 stop12h 08m

$363

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 5/1

4:49 pm-4:11 am

1 stop10h 22m

Santiago Arturo Merino Benitez

Sun 5/10

4:56 am-4:04 pm

1 stop12h 08m

$384

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 5/15

4:49 pm-4:11 am

1 stop10h 22m

Santiago Arturo Merino Benitez

Fri 5/29

4:56 am-4:04 pm

1 stop12h 08m

$387

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 4/19

4:49 pm-4:11 am

1 stop10h 22m

Santiago Arturo Merino Benitez

Sun 5/3

4:56 am-4:04 pm

1 stop12h 08m

$387

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 3/15

4:49 pm-10:39 am

1 stop15h 50m

Santiago Arturo Merino Benitez

Wed 3/25

5:59 am-4:00 pm

1 stop12h 01m

$407

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 3/22

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

Fri 5/15

4:56 am-4:04 pm

1 stop12h 08m

$408

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 3/22

4:49 pm-10:39 am

1 stop15h 50m

Santiago Arturo Merino Benitez

Sun 3/29

10:10 pm-11:10 am

1 stop15h 00m

$410

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 3/20

4:49 pm-10:39 am

1 stop15h 50m

$220

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 3/22

4:49 pm-10:39 am

1 stop15h 50m

$235

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 4/22

4:49 pm-4:16 am

1 stop10h 27m

$238

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/14

Showing 1-10 of 14 results
1
2

Compare providers for flights from Quito to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Quito to Santiago in January.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Quito-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Quito-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Quito-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Quito-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Quito-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Quito to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Quito with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Quito to Santiago

How far ahead should I book a flight from Quito to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Quito to Santiago. Price data was last updated on January 9, 2026.

The price you pay for your flight from Quito to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 42 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Quito to Santiago?

Currently, March is the cheapest month in which you can book a flight from Quito to Santiago (average of $125). Flying from Quito to Santiago in December is currently the most expensive (average of $186). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated January 15, 2026.
Read reviews from past customers who have flown Copa Airlines, LATAM Airlines, and JetSMART from Quito to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,559 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,559 reviews
Copa Airlines
7.6
Good
1,559 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
LATAM Airlines
7.5
Good
1,904 reviews
Copa Airlines
7.6
Good
1,559 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
JetSMART
6.7
Okay
260 reviews
Copa Airlines
7.6
Good
1,559 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,492 reviews
Copa Airlines
7.6
Good
1,559 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Quito to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Quito to Santiago?

    JetSMART can get you from Quito to Santiago in just under 10h 27m. Your travel time can differ by up to . There are 2349 mi between Quito and Santiago.

  • What are the cheapest airlines flying from Quito to Santiago round-trip?

    Currently priced at $161, JetSMART will fly you from Quito to Santiago and back. In addition to JetSMART, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Avianca and Copa Airlines - these airlines can fly you to your destination from $183 and $275, respectively. JetSMART is priced at 57% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Quito to Santiago one-way?

    The cheapest airlines for a one-way flight from Quito to Santiago are JetSMART ($185), Avianca ($238), and LATAM Airlines ($251).

  • Can I find deals for flights from Quito to Santiago that include hotel bookings?

    Yes. In addition to deals on Quito to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Quito to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Quito to Santiago.

  • Can I find deals for business class flights from Quito to Santiago?

    Yes. Cheapflights offers flight deals from Quito to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Quito to Santiago?

    Currently, March is the cheapest month in which you can book a flight from Quito to Santiago (average of $125). Flying from Quito to Santiago in December is currently the most expensive (average of $186). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Quito to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Guayaquil to Santiago flights

Top 4 airlines flying from Quito to Santiago

Discover the top 4 airlines that operate flights from Quito to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetSMARTCheapest$161Average$383FlexibilityNo cancel feeOn-timeN/A
AviancaCheapest$183Average$476FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$275Average$528FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$359Average$570FlexibilityNo cancel feeOn-time81%

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