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$213+ Cheap flights from Quito (UIO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/3. Fares are subject to change and may not be available on all flights or dates of travel.
UIO — SCL
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Quito Mariscal Sucr to Santiago Arturo Merino Benitez are usually found in April or May, booked 68 days in advance, depart on a Monday or Friday and return on a Friday

Cheap flight deals from Quito to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Quito (UIO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 17, 2025.

Round-trip from

$378
(JetSMART)

One-way from

$213
(Mytrip)

Popular in

February

Cheapest in

April

Average price

$425
From Quito Mariscal Sucr to Santiago Arturo Merino Benitez
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One-way flight from Quito Mariscal Sucr to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 8% potential increase in price ($33 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Quito to Santiago

Cheapest flights from Quito to Santiago
Explore the most affordable flight options available from Quito to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This FlightHub deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/194:49 pmUIO - SCL
1 stop10h 25mJetSMART
dom. 11/235:59 amSCL - UIO
1 stop12h 01mJetSMART
Deal found 9/17$405
This JetSMART deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/264:49 pmUIO - SCL
1 stop19h 41mJetSMART
sáb. 1/109:29 pmSCL - UIO
1 stop20h 31mJetSMART
Deal found 9/16$408
This JetSMART deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/74:49 pmUIO - SCL
1 stop10h 25mJetSMART
dom. 11/235:59 amSCL - UIO
1 stop12h 01mJetSMART
Deal found 9/17$415
This JetSMART deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/244:49 pmUIO - SCL
1 stop10h 25mJetSMART
mié. 12/315:59 amSCL - UIO
1 stop12h 01mJetSMART
Deal found 9/16$420
This Gotogate deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/87:55 amUIO - SCL
2 stops13h 35mMultiple Airlines
mié. 10/295:59 amSCL - UIO
1 stop12h 01mMultiple Airlines
Deal found 9/16$424
This JetSMART deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/174:41 pmUIO - SCL
1 stop10h 20mJetSMART
mié. 10/225:51 amSCL - UIO
1 stop12h 03mJetSMART
Deal found 9/17$426
This JetSMART deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/224:41 pmUIO - SCL
1 stop10h 20mJetSMART
vie. 10/315:59 amSCL - UIO
1 stop12h 01mJetSMART
Deal found 9/16$428
This Booking.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/174:49 pmUIO - SCL
1 stop10h 25mMultiple Airlines
mar. 1/64:25 pmSCL - UIO
1 stop10h 55mMultiple Airlines
Deal found 9/17$429
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/154:41 pmUIO - SCL
1 stop10h 20mMultiple Airlines
mar. 10/217:10 amSCL - UIO
1 stop9h 30mMultiple Airlines
Deal found 9/16$435
This JetSMART deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/104:41 pmUIO - SCL
1 stop10h 20mJetSMART
mié. 10/225:51 amSCL - UIO
1 stop12h 03mJetSMART
Deal found 9/16$438
This JetSMART deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/164:49 pmUIO - SCL
1 stop10h 25mJetSMART
mié. 11/265:59 amSCL - UIO
1 stop12h 01mJetSMART
Deal found 9/16$441

Cheapflights Fare Finder

 
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Quito

Fly to

Santiago

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 11/16

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

dom. 11/23

5:59 am-4:00 pm

1 stop12h 01m

$415

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

vie. 12/5

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

vie. 12/12

5:59 am-4:00 pm

1 stop12h 01m

$420

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

vie. 10/17

4:41 pm-5:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

mié. 10/22

5:51 am-3:54 pm

1 stop12h 03m

$426

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 11/5

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

dom. 11/9

5:59 am-4:00 pm

1 stop12h 01m

$428

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 10/22

4:41 pm-5:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

vie. 10/31

5:59 am-4:00 pm

1 stop12h 01m

$428

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 11/2

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

dom. 11/16

5:59 am-4:00 pm

1 stop12h 01m

$438

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 10/19

4:56 pm-5:01 am

1 stop10h 05m

Santiago Arturo Merino Benitez

mié. 10/22

5:51 am-3:54 pm

1 stop12h 03m

$458

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 12/31

3:30 am-3:20 pm

1 stop9h 50m

Santiago Arturo Merino Benitez

sáb. 1/31

9:29 pm-4:00 pm

1 stop20h 31m

$466

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mar. 2/3

3:30 am-3:20 pm

1 stop9h 50m

Santiago Arturo Merino Benitez

mié. 3/4

4:25 pm-1:20 am

1 stop10h 55m

$482

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

lun. 11/10

12:27 pm-3:43 am

1 stop13h 16m

Santiago Arturo Merino Benitez

jue. 11/13

12:20 pm-12:35 am

1 stop14h 15m

$487

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 19 results
1
2

Best time to book a flight from Quito to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Quito with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Quito to Santiago

How far ahead should I book a flight from Quito to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Quito to Santiago. Price data was last updated on September 12, 2025.

The price you pay for your flight from Quito to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 68 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Quito to Santiago?

Currently, April is the cheapest month in which you can book a flight from Quito to Santiago (average of $752). Flying from Quito to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from UIO to SCL?

Find hourly flight availability from Quito to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 17, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 9% on flights from Quito to Santiago by exploring options for tickets at noon.

What is the cheapest day to fly from Quito to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Quito to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Quito to Santiago flight should consider departing on Monday at noon when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Quito to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated septiembre 17, 2025.
Read reviews from past customers who have flown Copa Airlines, LATAM Airlines, and Avianca from Quito to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,533 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,533 reviews
Copa Airlines
7.6
Good
1,533 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
LATAM Airlines
7.5
Good
1,849 reviews
Copa Airlines
7.6
Good
1,533 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,533 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
JetSMART
6.5
Okay
225 reviews
Copa Airlines
7.6
Good
1,533 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Quito to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Quito to Santiago?

    JetSMART can get you from Quito to Santiago in just under 10h 25m. Your travel time can differ by up to . There are 2349 mi between Quito and Santiago.

  • What are the cheapest airlines flying from Quito to Santiago round-trip?

    Currently priced at $161, JetSMART will fly you from Quito to Santiago and back. In addition to JetSMART, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Copa Airlines and Avianca - these airlines can fly you to your destination from $183 and $207, respectively. JetSMART is priced at 56% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Quito to Santiago that include hotel bookings?

    Yes. In addition to deals on Quito to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Quito to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Quito to Santiago.

  • Can I find deals for business class flights from Quito to Santiago?

    Yes. Cheapflights offers flight deals from Quito to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Quito to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Quito to Santiago (average of $752). Flying from Quito to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Quito to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Guayaquil to Santiago flights

Top 4 airlines flying from Quito to Santiago

Discover the top 4 airlines that operate flights from Quito to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetSMARTCheapest$161Average$372FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$183Average$507FlexibilityNo cancel feeOn-time70%
AviancaCheapest$207Average$467FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$354Average$508FlexibilityNo cancel feeOn-time81%

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