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$320+ Cheap flights from Columbus (CMH) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — SCL
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
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Cheap flight deals from Columbus to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (CMH) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 20, 2025.

Round-trip from

$604
(Avianca Connect)

One-way from

$320
(eDestinos)

Popular in

December

Cheapest in

October

Average price

$906
From Columbus to Santiago Arturo Merino Benitez
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One-way flight from Columbus to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 4% potential increase in price ($41 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Columbus to Santiago

Cheapest flights from Columbus to Santiago
Explore the most affordable flight options available from Columbus to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This Avianca Connect deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/18:34 amCMH - SCL
2 stops19h 41mMultiple Airlines
Sun 10/1212:55 amSCL - CMH
2 stops18h 14mMultiple Airlines
Deal found 8/19$604
This Avianca Connect deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/15:15 amCMH - SCL
2 stops23h 00mMultiple Airlines
Wed 10/812:55 amSCL - CMH
2 stops18h 14mMultiple Airlines
Deal found 8/19$627
This Avianca Connect deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/212:31 pmCMH - SCL
2 stops15h 44mMultiple Airlines
Wed 10/812:55 amSCL - CMH
2 stops18h 14mMultiple Airlines
Deal found 8/18$628
This Trip.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/18:34 amCMH - SCL
2 stops21h 11mMultiple Airlines
Fri 10/1012:25 amSCL - CMH
2 stops36h 02mMultiple Airlines
Deal found 8/18$661
This Avianca Connect deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/185:15 amCMH - SCL
2 stops23h 00mMultiple Airlines
Wed 9/2412:55 amSCL - CMH
2 stops18h 16mMultiple Airlines
Deal found 8/20$673
This Avianca Connect deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/38:34 amCMH - SCL
2 stops19h 41mMultiple Airlines
Thu 10/912:55 amSCL - CMH
2 stops18h 14mMultiple Airlines
Deal found 8/19$710
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/111:54 amCMH - SCL
1 stop18h 51mLATAM Airlines
Thu 10/910:55 pmSCL - CMH
1 stop19h 45mLATAM Airlines
Deal found 8/19$727

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Columbus Airport to Santiago that are best for you.

Fly from

Columbus

Fly to

Santiago

Route

Depart

Return

Price

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Wed 10/1

8:34 am-5:15 am

2 stops19h 41m

Santiago Arturo Merino Benitez

Sun 10/12

12:55 am-6:09 pm

2 stops18h 14m

$604

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Wed 10/1

5:15 am-5:15 am

2 stops23h 00m

Santiago Arturo Merino Benitez

Wed 10/8

12:55 am-6:09 pm

2 stops18h 14m

$627

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Thu 10/2

12:31 pm-5:15 am

2 stops15h 44m

Santiago Arturo Merino Benitez

Wed 10/8

12:55 am-6:09 pm

2 stops18h 14m

$628

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Wed 10/1

8:34 am-6:45 am

2 stops21h 11m

Santiago Arturo Merino Benitez

Fri 10/10

12:25 am-11:27 am

2 stops36h 02m

$661

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Thu 9/18

5:15 am-5:15 am

2 stops23h 00m

Santiago Arturo Merino Benitez

Wed 9/24

12:55 am-6:11 pm

2 stops18h 16m

$673

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Fri 10/3

8:34 am-5:15 am

2 stops19h 41m

Santiago Arturo Merino Benitez

Thu 10/9

12:55 am-6:09 pm

2 stops18h 14m

$710

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Wed 10/1

11:54 am-7:45 am

1 stop18h 51m

Santiago Arturo Merino Benitez

Thu 10/9

10:55 pm-5:40 pm

1 stop19h 45m

$727

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Wed 10/1

7:07 am-7:45 am

1 stop23h 38m

Santiago Arturo Merino Benitez

Mon 10/13

10:50 pm-5:40 pm

1 stop19h 50m

$744

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Sat 8/30

6:44 pm-4:15 am

2 stops33h 31m

$320

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Thu 1/22

9:10 pm-3:20 pm

2 stops40h 10m

$350

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Showing 1-10 of 16 results
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Best time to book a flight from Columbus to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to Santiago

What is the cheapest month to book a flight from Columbus Airport to Santiago?

Currently, April is the cheapest month in which you can book a flight from Columbus Airport to Santiago (average of $752). Flying from Columbus Airport to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to SCL?

Find hourly flight availability from Columbus to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2025.

When flying from Columbus Airport to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 17% versus a flight in the afternoon.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated August 20, 2025.
Get a feel of what it's like to fly with Delta and LATAM Airlines from Columbus Airport to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,844 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Columbus to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Columbus?

    Located just 8.4 mi from the city center, Santiago Arturo Merino Benitez is the airport most travelers will use when flying to Santiago from Columbus. Booking flights from Columbus to Arturo Merino Benitez (SCL) should be relatively easy as there are 0 daily inbound flights from Columbus from 2 different airlines.

  • What are the cheapest airlines flying from Columbus Airport to Santiago round-trip?

    According to our current data, Delta ($732), and LATAM Airlines ($732) offers the cheapest pricing from Columbus Airport to Santiago. Delta is currently priced 24% below the average price you’ll pay for this route.

  • Can I find deals for flights from Columbus to Santiago that include hotel bookings?

    Yes. In addition to deals on Columbus to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Santiago.

  • Can I find deals for business class flights from Columbus to Santiago?

    Yes. Cheapflights offers flight deals from Columbus to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus Airport to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Columbus Airport to Santiago (average of $752). Flying from Columbus Airport to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
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Lastarria car rentals

Top 2 airlines flying from Columbus to Santiago

Discover the top 2 airlines that operate flights from Columbus to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$732Average$1,026FlexibilityNo cancel feeOn-time81%
DeltaCheapest$732Average$1,098FlexibilityNo cancel feeOn-timeN/A

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