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$260+ Cheap flights from Mexico City (MEX) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in May or August, booked 90 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This LATAM Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:15 pmMEX - SCL
1 stop15h 20mLATAM Airlines
Wed 12/179:10 amSCL - MEX
Nonstop8h 40mLATAM Airlines
Deal found 10/30$519
This LATAM Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/147:50 pmMEX - SCL
Nonstop8h 40mLATAM Airlines
Wed 12/249:10 amSCL - MEX
Nonstop8h 40mLATAM Airlines
Deal found 10/29$543
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:55 amMEX - SCL
1 stop14h 46mCopa Airlines
Tue 12/212:20 pmSCL - MEX
1 stop14h 55mCopa Airlines
Deal found 10/28$548
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:00 pmMEX - SCL
2 stops16h 05mLATAM Airlines
Wed 12/249:10 amSCL - MEX
Nonstop8h 40mLATAM Airlines
Deal found 10/28$552
This Copa Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/22:00 amMEX - SCL
1 stop19h 24mCopa Airlines
Tue 12/93:23 amSCL - MEX
1 stop18h 57mCopa Airlines
Deal found 10/28$564
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/254:00 pmMEX - SCL
1 stop20h 30mLATAM Airlines
Tue 12/29:10 amSCL - MEX
Nonstop8h 40mLATAM Airlines
Deal found 10/28$565
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/22:00 amMEX - SCL
1 stop15h 21mCopa Airlines
Wed 12/2412:20 pmSCL - MEX
1 stop12h 45mCopa Airlines
Deal found 10/28$570
This Priceline deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/295:00 amMEX - SCL
1 stop21h 30mAvianca
Wed 8/1211:55 pmSCL - MEX
1 stop14h 10mAvianca
Deal found 10/28$584
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/11:20 amMEX - SCL
1 stop20h 04mCopa Airlines
Tue 12/161:08 amSCL - MEX
1 stop21h 12mCopa Airlines
Deal found 10/30$585
This Booking.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1612:40 amMEX - SCL
1 stop20h 50mMultiple Airlines
Wed 11/269:10 amSCL - MEX
Nonstop8h 40mMultiple Airlines
Deal found 10/29$593
This LATAM Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/177:50 pmMEX - SCL
Nonstop8h 40mLATAM Airlines
Sat 1/319:10 amSCL - MEX
Nonstop8h 40mLATAM Airlines
Deal found 10/30$595

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$519
(LATAM Airlines)

One-way from

$260
(Kiwi.com)

Popular in

February

Cheapest in

May

Average price

$613

Good round-trip deal

$617 or less

Good one-way deal

$341 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flights.
Search Deals
From Mexico City Benito Juarez to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($53 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a round-trip flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 12/2

2:00 am-11:41 pm

1 stop18h 41m

Santiago Arturo Merino Benitez

Wed 12/10

12:20 pm-1:00 am

1 stop15h 40m

$564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 12/3

9:25 am-6:01 am

1 stop17h 36m

Santiago Arturo Merino Benitez

Wed 12/10

1:08 am-7:20 pm

1 stop21h 12m

$564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 11/24

1:20 am-8:21 pm

1 stop16h 01m

Santiago Arturo Merino Benitez

Mon 12/1

3:23 am-7:20 pm

1 stop18h 57m

$564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 3/12

9:25 am-11:49 pm

1 stop11h 24m

Santiago Arturo Merino Benitez

Wed 3/18

3:32 am-7:20 pm

1 stop18h 48m

$564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 12/1

1:20 am-8:21 pm

1 stop16h 01m

Santiago Arturo Merino Benitez

Tue 12/9

5:44 am-7:20 pm

1 stop16h 36m

$564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 3/16

9:25 am-11:49 pm

1 stop11h 24m

Santiago Arturo Merino Benitez

Tue 3/24

3:32 am-10:05 pm

1 stop21h 33m

$564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 11/25

2:00 am-12:06 am

1 stop19h 06m

Santiago Arturo Merino Benitez

Sun 12/7

1:29 am-7:20 pm

1 stop20h 51m

$585

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 12/2

9:25 am-6:01 am

1 stop17h 36m

Santiago Arturo Merino Benitez

Tue 12/16

3:23 am-7:20 pm

1 stop18h 57m

$585

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 12/13

2:00 am-11:41 pm

1 stop18h 41m

Santiago Arturo Merino Benitez

Tue 12/23

3:23 am-2:30 pm

1 stop14h 07m

$611

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 12/28

2:00 am-12:24 am

1 stop19h 24m

$264

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 18 results
1
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Compare providers for flights from Mexico City to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Santiago in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
CheapflightsfaresPrice Accuracy3 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Mexico City-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Mexico City-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Mexico City-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mexico City-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on October 24, 2025.

The best time to book flights from Mexico City to Santiago is 90 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, December is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $306). Flying from Mexico City to Santiago in February is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

When flying from Mexico City to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 41% versus a flight in the morning.

What is the cheapest day to fly from Mexico City to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Santiago. Price data was last updated on October 26, 2025.

Travelers seeking maximum savings on their Mexico City to Santiago flight should consider departing on Wednesday at noon when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Mexico City to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 30, 2025.
See what other customers who have flown with Copa Airlines, LATAM Airlines, and Aeromexico from Mexico City to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
LATAM Airlines
7.5
Good
1,872 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Aeromexico
7.4
Good
1,674 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,467 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mexico City to Santiago?

    If you wish to fly to Santiago from Mexico City, then you need to book flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez. There are 2 flights from Benito Juarez (MEX) to Arturo Merino Benitez (SCL) per day to choose from. Flights to Santiago from Benito Juarez are available from 4 different airlines, which means you should have some options if you want to compare airfare deals. 8h 10m is how long a nonstop flight from Mexico City to Santiago Arturo Merino Benitez typically takes.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 2 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • How long is the flight from Mexico City to Santiago?

    For as low as $564, Copa Airlines can have you in Santiago from Mexico City in 18h 41m. The distance between Mexico City and Santiago is about 4096 mi.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from $323. Other airlines that can offer you cheap pricing are Avianca, from $330, and Copa Airlines, from $423. Users have found that Aeromexico is 48% cheaper than the other options available to this destination.

  • What are the cheapest flights from Mexico City to Santiago?

    While on average a flight from Mexico City to Santiago is generally $1,008, our data shows the cheapest flight currently is $283. When looking at the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), you can expect to pay $463 for that flight.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, December is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $306). Flying from Mexico City to Santiago in February is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Temuco car rentals
Lastarria car rentals

Top 4 airlines flying from Mexico City to Santiago

Discover the top 4 airlines that operate flights from Mexico City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$323Average$847FlexibilityNo cancel feeOn-timeN/A
AviancaCheapest$330Average$587FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$423Average$646FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$483Average$697FlexibilityNo cancel feeOn-time81%

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