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$289+ Cheap flights from Mexico City (MEX) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
ago 4 — ago 111
seg 8/4
seg 8/11
1 adult, Economy
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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in May or March, booked 90 days in advance, depart on a Thursday or Tuesday and return on a Thursday

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated julho 30, 2025.

Round-trip from

$537
(Kiwi.com)

One-way from

$289
(Avianca)

Popular in

December

Cheapest in

May

Average price

$618

Good round-trip deal

$586 or less

Good one-way deal

$646 or less
From Mexico City Benito Juarez to Santiago Arturo Merino Benitez
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One-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 6% potential increase in price ($46 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
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Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julho 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 8/79:50 amMEX - SCL
1 stop11h 18mCopa Airlines
ter 8/124:11 amSCL - MEX
1 stop12h 19mCopa Airlines
Deal found 7/29$533
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 9/1512:40 amMEX - SCL
2 stops31h 40mMultiple Airlines
seg 9/229:15 pmSCL - MEX
2 stops16h 40mMultiple Airlines
Deal found 7/29$549
This LATAM Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 11/177:50 pmMEX - SCL
Nonstop8h 05mLATAM Airlines
sex 11/289:15 amSCL - MEX
Nonstop8h 40mLATAM Airlines
Deal found 7/30$554
This Cheapflightsfares deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 11/231:50 pmMEX - SCL
1 stop12h 40mAvianca
qua 11/261:35 amSCL - MEX
1 stop19h 35mAvianca
Deal found 7/30$573
This Aeromexico deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 11/610:00 amMEX - SCL
Nonstop8h 15mAeromexico
ter 11/1811:25 pmSCL - MEX
Nonstop8h 40mAeromexico
Deal found 7/29$626

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julho 30, 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

ter 8/12

9:50 am-11:08 pm

1 stop11h 18m

Santiago Arturo Merino Benitez

sáb 8/16

4:11 am-2:30 pm

1 stop12h 19m

$537

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

seg 9/15

12:40 am-11:20 am

2 stops31h 40m

Santiago Arturo Merino Benitez

seg 9/22

9:15 pm-10:55 am

2 stops16h 40m

$549

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

seg 11/17

7:50 pm-6:55 am

Nonstop8h 05m

Santiago Arturo Merino Benitez

sex 11/28

9:15 am-2:55 pm

Nonstop8h 40m

$554

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

dom 11/23

1:50 pm-5:30 am

1 stop12h 40m

Santiago Arturo Merino Benitez

qua 11/26

1:35 am-6:10 pm

1 stop19h 35m

$573

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

qui 11/6

10:00 am-9:15 pm

Nonstop8h 15m

Santiago Arturo Merino Benitez

ter 11/18

11:25 pm-5:05 am

Nonstop8h 40m

$626

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

seg 12/8

12:40 am-11:40 pm

1 stop44h 00m

$289

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

ter 10/7

4:50 pm-2:45 pm

2 stops18h 55m

$293

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

qua 12/10

7:50 pm-6:55 am

Nonstop8h 05m

$296

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

dom 8/10

1:40 am-10:44 pm

1 stop19h 04m

$438

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

seg 12/15

10:10 am-9:15 pm

Nonstop8h 05m

$572

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on July 25, 2025.

The best time to book flights from Mexico City to Santiago is 90 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $752). Flying from Mexico City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julho 30, 2025.

When flying from Mexico City to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 27% versus a flight in the morning.

What is the cheapest day to fly from Mexico City to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Santiago. Price data was last updated on July 27, 2025.

Travelers seeking maximum savings on their Mexico City to Santiago flight should consider departing on Thursday at noon when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Mexico City to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated julho 30, 2025.
See what other customers who have flown with LATAM Airlines, Copa Airlines, and Aeromexico from Mexico City to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,822 reviews

Boarding

7.6

Food

6.7

Entertainment

7.0

Comfort

7.4

Crew

8.1

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
LATAM Airlines
7.5
Good
1,822 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Boarding

7.6

Food

6.7

Entertainment

7.0

Comfort

7.4

Crew

8.1

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Copa Airlines
7.5
Good
1,493 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Boarding

7.6

Food

6.7

Entertainment

7.0

Comfort

7.4

Crew

8.1

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Aeromexico
7.5
Good
1,721 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Boarding

7.6

Food

6.7

Entertainment

7.0

Comfort

7.4

Crew

8.1

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Avianca
6.7
Okay
2,387 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Boarding

7.6

Food

6.7

Entertainment

7.0

Comfort

7.4

Crew

8.1

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 5 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from $537. Other airlines that can offer you cheap pricing are LATAM Airlines, from $554, and Avianca, from $573. Users have found that Copa Airlines is 15% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mexico City to Santiago one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $289. LATAM Airlines flights start at $296 while deals on Copa Airlines start at $438 one-way.

  • What are the cheapest flights from Mexico City to Santiago?

    While on average a flight from Mexico City to Santiago is generally $677, our data shows the cheapest flight currently is $516. When looking at the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), you can expect to pay $536 for that flight.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $752). Flying from Mexico City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Punta Arenas car rentals
Temuco car rentals
Lastarria car rentals

Top 4 airlines flying from Mexico City to Santiago

Discover the top 4 airlines that operate flights from Mexico City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julho 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$314Average$660FlexibilityNo cancel feeOn-time70%
AviancaCheapest$330Average$587FlexibilityNo cancel feeOn-time71%
AeromexicoCheapest$384Average$754FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$491Average$677FlexibilityNo cancel feeOn-time81%

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