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$247+ Cheap flights from Mexico City (MEX) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in May or March, booked 74 days in advance, depart on a Thursday or Sunday and return on a Thursday

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$486
(Avianca Connect)

One-way from

$250
(Avianca Connect)

Popular in

December

Cheapest in

May

Average price

$633

Good round-trip deal

$508 or less

Good one-way deal

$588 or less
From Mexico City Benito Juarez to Santiago Arturo Merino Benitez
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One-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 6% potential increase in price ($47 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Price to beat on a round-trip flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
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Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This LATAM Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/243:10 pmMEX - SCL
1 stop10h 20mLATAM Airlines
Fri 10/105:15 amSCL - MEX
1 stop11h 35mLATAM Airlines
Deal found 6/11$474
This Avianca Connect deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1912:40 amMEX - SCL
1 stop19h 50mAvianca
Wed 8/276:10 amSCL - MEX
1 stop18h 50mAvianca
Deal found 6/10$486
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/161:05 pmMEX - SCL
1 stop11h 20mCopa Airlines
Thu 7/244:10 amSCL - MEX
1 stop12h 20mCopa Airlines
Deal found 6/9$517
This Trip.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2110:05 pmMEX - SCL
1 stop21h 05mMultiple Airlines
Wed 11/261:30 amSCL - MEX
2 stops36h 30mMultiple Airlines
Deal found 6/12$556

Cheapflights Fare Finder

Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 9/24

3:10 pm-4:30 am

1 stop10h 20m

Santiago Arturo Merino Benitez

Fri 10/10

5:15 am-1:50 pm

1 stop11h 35m

$474

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 8/19

12:40 am-10:30 pm

1 stop19h 50m

Santiago Arturo Merino Benitez

Wed 8/27

6:10 am-11:00 pm

1 stop18h 50m

$486

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 7/16

1:05 pm-2:25 am

1 stop11h 20m

Santiago Arturo Merino Benitez

Thu 7/24

4:10 am-2:30 pm

1 stop12h 20m

$517

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 10/21

10:05 pm-10:10 pm

1 stop21h 05m

Santiago Arturo Merino Benitez

Wed 11/26

1:30 am-11:00 am

2 stops36h 30m

$556

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 9/24

12:40 am-11:30 pm

1 stop19h 50m

$247

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 10/21

10:05 pm-10:10 pm

1 stop21h 05m

$252

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 6/30

1:40 am-11:08 pm

1 stop19h 28m

$363

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 7/11

8:20 pm-6:40 am

Nonstop8h 20m

$543

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 12/6

1:10 am-2:20 pm

2 stops34h 10m

$732

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 12/6

1:00 am-9:25 am

2 stops29h 25m

$796

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 11 results
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on June 9, 2025.

The best time to book flights from Mexico City to Santiago is 74 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $752). Flying from Mexico City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Mexico City to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 25% versus a flight in the evening.

What is the cheapest day to fly from Mexico City to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Santiago. Price data was last updated on June 8, 2025.

Travelers seeking maximum savings on their Mexico City to Santiago flight should consider departing on Sunday mornings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 12, 2025.
Read through reviews of airlines operating flights from Mexico City to Santiago, such as LATAM Airlines, Qantas Airways and Copa Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,785 reviews

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.
LATAM Airlines
7.5
Good
1,785 reviews
LATAM Airlines
7.5
Good
1,785 reviews

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.
Qantas Airways
7.5
Good
854 reviews
LATAM Airlines
7.5
Good
1,785 reviews

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.
Copa Airlines
7.5
Good
1,451 reviews
LATAM Airlines
7.5
Good
1,785 reviews

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.
Air Canada
7.1
Good
9,531 reviews
LATAM Airlines
7.5
Good
1,785 reviews

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.
Avianca
6.7
Okay
2,345 reviews
LATAM Airlines
7.5
Good
1,785 reviews

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 5 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from $486. Other airlines that can offer you cheap pricing are Copa Airlines, from $517, and LATAM Airlines, from $536. Users have found that Avianca is 23% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mexico City to Santiago one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $250. Copa Airlines flights start at $363 while deals on LATAM Airlines start at $543 one-way.

  • What are the cheapest flights from Mexico City to Santiago?

    While on average a flight from Mexico City to Santiago is generally $615, our data shows the cheapest flight currently is $343. When looking at the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), you can expect to pay $448 for that flight.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $752). Flying from Mexico City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Punta Arenas car rentals
Temuco car rentals
Lastarria car rentals

Top 4 airlines flying from Mexico City to Santiago

Discover the top 4 airlines that operate flights from Mexico City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$330Average$596FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$347Average$665FlexibilityNo cancel feeOn-time70%
AeromexicoCheapest$384Average$720FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$506Average$682FlexibilityNo cancel feeOn-time81%

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