How popular is this Mexico City to Santiago flight route?

Within the past month, 5 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

How long is the flight from Mexico City to Santiago?

For as low as $546, Copa Airlines can have you in Santiago from Mexico City in 18h 41m. The distance between Mexico City and Santiago is about 4096 mi.

What are the cheapest airlines flying from Mexico City to Santiago round-trip?

Cheapflights users have booked flights from Mexico City to Santiago round-trip from $314. Other airlines that can offer you cheap pricing are Avianca, from $330, and Aeromexico, from $343. Users have found that Copa Airlines is 50% cheaper than the other options available to this destination.

Weekly flight availability from Mexico City to Santiago

The most flights from MEX to SCL are scheduled on a Monday (1 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

What are the cheapest flights from Mexico City to Santiago?

While on average a flight from Mexico City to Santiago is generally $1,203, our data shows the cheapest flight currently is $530. When looking at the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), you can expect to pay $519 for that flight.

What are the most popular airlines that fly from Mexico City to Santiago?

Before booking your flight from Mexico City to Santiago check out the most popular airlines for this route: Aeromexico, Avianca or Copa Airlines.

What is the cheapest day to fly round-trip from Mexico City to Santiago?

Users have found that leaving on a Wednesday can be a cost-effective option. It’s possible to save up to 43% on your flight compared to booking on days when demand is much higher.

How far in advance should I book a flight from Mexico City to Santiago?

To save on the cost of your flight from Mexico City to Santiago, book at least 57 days before your planned departure. Booking around this time can save you about 29% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $677 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $731.

What is the cheapest month to fly from Mexico City to Santiago?

Our data shows that May tends to be the cheapest month to fly to Santiago from Mexico City. Users have commonly found prices around $628 for the month, but tickets can be as low as $345. Due to multiple factors, prepare for potentially higher prices in December.

What airports do I use to fly from Mexico City to Santiago?

If you wish to fly to Santiago from Mexico City, then you need to book flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez. There is 1 flight from Benito Juarez (MEX) to Arturo Merino Benitez (SCL) per day to choose from. Flights to Santiago from Benito Juarez are available from 4 different airlines, which means you should have some options if you want to compare airfare deals. 8h 00m is how long a nonstop flight from Mexico City to Santiago Arturo Merino Benitez typically takes.

Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mexico City to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

Can I find deals for business class flights from Mexico City to Santiago?

Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$272+ Flights from Mexico City to Santiago

Q: How much does it cost to fly round-trip from Mexico City to Santiago?

Airfare is below average for this route at the moment. Mexico City to Santiago flights typically cost between $561 and $736 in October. The cheapest round-trip price found within the last 3 days was $515 on LATAM Airlines (Oct 29-Nov 11).

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Find cheap flights from Mexico City to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in May or July, booked 90 days in advance, depart on a Thursday or Wednesday and return on a Thursday

Cheap flight deals from Mexico City to Santiago

Round-trip from	$515 (LATAM Airlines)
One-way from	$272 (Cheapflightsfares)
Popular in	December
Cheapest in	May
Average price	$632
Good round-trip deal	$585 or less
Good one-way deal	$667 or less

From Mexico City Benito Juarez to Santiago Arturo Merino Benitez

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One-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($48 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Price to beat on a round-trip flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

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Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Wed 10/295:15 pmMEX - SCL

1 stop16h 35mLATAM Airlines

Tue 11/114:35 amSCL - MEX

1 stop12h 15mLATAM Airlines

Deal found 9/10

$515

Fri 10/34:55 amMEX - SCL

1 stop15h 35mAvianca

Sun 10/127:10 amSCL - MEX

1 stop13h 55mAvianca

Deal found 9/10

$517

Tue 10/215:20 pmMEX - SCL

1 stop15h 10mLATAM Airlines

Fri 10/319:10 amSCL - MEX

Nonstop8h 40mLATAM Airlines

Deal found 9/10

$519

Mon 10/611:20 pmMEX - SCL

1 stop12h 05mAvianca

Sun 10/127:10 amSCL - MEX

1 stop13h 55mAvianca

Deal found 9/10

$522

Wed 10/84:55 amMEX - SCL

1 stop15h 35mAvianca

Wed 10/153:30 pmSCL - MEX

1 stop14h 35mAvianca

Deal found 9/10

$525

Mon 11/177:50 pmMEX - SCL

Nonstop8h 05mLATAM Airlines

Fri 11/285:15 amSCL - MEX

1 stop11h 35mLATAM Airlines

Deal found 9/10

$526

Thu 10/22:00 amMEX - SCL

1 stop15h 20mCopa Airlines

Wed 10/1512:29 pmSCL - MEX

1 stop12h 36mCopa Airlines

Deal found 9/10

$527

Wed 10/11:05 pmMEX - SCL

1 stop13h 55mCopa Airlines

Wed 10/812:29 pmSCL - MEX

1 stop12h 31mCopa Airlines

Deal found 9/11

$528

Fri 11/147:50 pmMEX - SCL

Nonstop8h 05mLATAM Airlines

Tue 11/259:15 amSCL - MEX

Nonstop8h 40mLATAM Airlines

Deal found 9/9

$530

Mon 10/69:50 amMEX - SCL

1 stop11h 14mCopa Airlines

Mon 10/134:47 amSCL - MEX

1 stop20h 18mCopa Airlines

Deal found 9/10

$532

Wed 10/82:00 amMEX - SCL

1 stop19h 04mCopa Airlines

Thu 10/164:47 amSCL - MEX

1 stop22h 28mCopa Airlines

Deal found 9/11

$533

Tue 10/77:05 pmMEX - SCL

2 stops15h 15mMultiple Airlines

Mon 10/136:30 pmSCL - MEX

1 stop23h 25mMultiple Airlines

Deal found 9/10

$534

Best flights from Mexico City to Santiago
Discover carefully curated flight deals from Mexico City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2025.

Mon 11/172:00 amMEX - SCL

1 stop18h 41mCopa Airlines

Thu 11/273:23 amSCL - MEX

1 stop21h 42mCopa Airlines

Deal found 9/11

$546

Sun 10/122:00 amMEX - SCL

1 stop15h 20mCopa Airlines

Mon 11/105:12 amSCL - MEX

1 stop17h 08mCopa Airlines

Deal found 9/11

$546

Thu 10/21:05 pmMEX - SCL

1 stop11h 37mCopa Airlines

Thu 10/94:47 amSCL - MEX

1 stop22h 28mCopa Airlines

Deal found 9/9

$546

Sun 11/162:00 amMEX - SCL

1 stop15h 21mCopa Airlines

Thu 11/273:23 amSCL - MEX

1 stop18h 57mCopa Airlines

Deal found 9/11

$546

Wed 11/129:25 amMEX - SCL

1 stop11h 41mCopa Airlines

Tue 12/212:20 pmSCL - MEX

1 stop15h 40mCopa Airlines

Deal found 9/10

$546

Thu 9/259:50 amMEX - SCL

1 stop14h 52mCopa Airlines

Mon 10/63:35 amSCL - MEX

1 stop21h 30mCopa Airlines

Deal found 9/11

$546

Wed 9/245:50 amMEX - SCL

1 stop15h 14mCopa Airlines

Sat 9/273:26 amSCL - MEX

1 stop21h 39mCopa Airlines

Deal found 9/10

$546

Wed 10/13:30 pmMEX - SCL

1 stop11h 30mCopa Airlines

Tue 10/73:35 amSCL - MEX

1 stop21h 30mCopa Airlines

Deal found 9/11

$546

Last-minute flights from Mexico City to Santiago
Discover last-minute flight deals from Mexico City to Santiago. Data last updated September 11, 2025 and is based on user searches.

Wed 10/11:05 pmMEX - SCL

1 stop13h 55mCopa Airlines

Wed 10/812:29 pmSCL - MEX

1 stop12h 31mCopa Airlines

Deal found 9/11

$528

Thu 10/22:00 amMEX - SCL

1 stop15h 20mCopa Airlines

Wed 10/1512:29 pmSCL - MEX

1 stop12h 36mCopa Airlines

Deal found 9/10

$527

Fri 10/34:55 amMEX - SCL

1 stop15h 35mAvianca

Sat 10/117:10 amSCL - MEX

1 stop13h 55mAvianca

Deal found 9/10

$517

Sun 10/512:40 amMEX - SCL

1 stop19h 50mAvianca

Mon 10/137:10 amSCL - MEX

1 stop22h 55mAvianca

Deal found 9/10

$536

Mon 10/611:20 pmMEX - SCL

1 stop12h 05mAvianca

Sun 10/127:10 amSCL - MEX

1 stop13h 55mAvianca

Deal found 9/10

$522

Mon 10/69:50 amMEX - SCL

1 stop11h 14mCopa Airlines

Mon 10/134:47 amSCL - MEX

1 stop20h 18mCopa Airlines

Deal found 9/10

$532

Tue 10/77:05 pmMEX - SCL

2 stops15h 15mMultiple Airlines

Mon 10/136:30 pmSCL - MEX

1 stop23h 25mMultiple Airlines

Deal found 9/10

$534

Wed 10/84:55 amMEX - SCL

1 stop15h 35mAvianca

Wed 10/153:30 pmSCL - MEX

1 stop14h 35mAvianca

Deal found 9/10

$525

Wed 10/82:00 amMEX - SCL

1 stop18h 40mCopa Airlines

Wed 10/153:35 amSCL - MEX

1 stop24h 25mCopa Airlines

Deal found 9/11

$533

Wed 10/81:05 pmMEX - SCL

1 stop11h 37mCopa Airlines

Fri 10/104:47 amSCL - MEX

1 stop12h 43mCopa Airlines

Deal found 9/10

$541

Tue 10/215:20 pmMEX - SCL

1 stop15h 10mLATAM Airlines

Fri 10/319:10 amSCL - MEX

Nonstop8h 40mLATAM Airlines

Deal found 9/10

$519

Wed 10/295:15 pmMEX - SCL

1 stop16h 35mLATAM Airlines

Tue 11/114:35 amSCL - MEX

1 stop12h 15mLATAM Airlines

Deal found 9/10

$515

One-way flights from Mexico City to Santiago
Search for one-way flight options from Mexico City to Santiago. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.

Sat 12/612:40 amMEX - SCL

1 stop11h 40mAvianca

Deal found 9/10

$272

Sat 10/44:55 amMEX - SCL

1 stop15h 35mAvianca

Deal found 9/11

$273

Thu 10/232:00 pmMEX - SCL

2 stops36h 01mMultiple Airlines

Deal found 9/11

$283

Mon 12/87:50 pmMEX - SCL

Nonstop8h 05mLATAM Airlines

Deal found 9/10

$284

Fri 11/2811:15 pmMEX - SCL

2 stops20h 00mMultiple Airlines

Deal found 9/11

$285

Thu 12/115:00 amMEX - SCL

2 stops41h 21mMultiple Airlines

Deal found 9/10

$288

Wed 12/104:00 pmMEX - SCL

2 stops14h 09mLATAM Airlines

Deal found 9/10

$292

Thu 12/255:00 amMEX - SCL

1 stop16h 30mAvianca

Deal found 9/10

$297

Thu 1/297:50 pmMEX - SCL

Nonstop8h 05mLATAM Airlines

Deal found 9/10

$300

Fri 1/304:00 pmMEX - SCL

1 stop10h 50mLATAM Airlines

Deal found 9/10

$308

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 11/17

2:00 am-11:41 pm

1 stop18h 41m

Santiago Arturo Merino Benitez

Thu 11/27

3:23 am-10:05 pm

1 stop21h 42m

$546

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 10/12

2:00 am-8:20 pm

1 stop15h 20m

Santiago Arturo Merino Benitez

Mon 11/10

5:12 am-7:20 pm

1 stop17h 08m

$546

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 10/2

1:05 pm-3:42 am

1 stop11h 37m

Santiago Arturo Merino Benitez

Thu 10/9

4:47 am-12:15 am

1 stop22h 28m

$546

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 11/16

2:00 am-8:21 pm

1 stop15h 21m

Santiago Arturo Merino Benitez

Thu 11/27

3:23 am-7:20 pm

1 stop18h 57m

$546

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 11/12

9:25 am-12:06 am

1 stop11h 41m

Santiago Arturo Merino Benitez

Tue 12/2

12:20 pm-1:00 am

1 stop15h 40m

$546

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 9/25

9:50 am-3:42 am

1 stop14h 52m

Santiago Arturo Merino Benitez

Mon 10/6

3:35 am-10:05 pm

1 stop21h 30m

$546

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 9/24

5:50 am-12:04 am

1 stop15h 14m

Santiago Arturo Merino Benitez

Sat 9/27

3:26 am-10:05 pm

1 stop21h 39m

$546

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 10/1

3:30 pm-6:00 am

1 stop11h 30m

Santiago Arturo Merino Benitez

Tue 10/7

3:35 am-10:05 pm

1 stop21h 30m

$546

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 10/29

12:40 am-3:20 pm

1 stop11h 40m

$272

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 12/28

12:40 am-3:20 pm

1 stop11h 40m

$272

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 16 results

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

Prices

Airlines

How far ahead should I book a flight from Mexico City to Santiago?

The best time to book flights from Mexico City to Santiago is 90 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $752). Flying from Mexico City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

When flying from Mexico City to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 37% versus a flight in the morning.

What is the cheapest day to fly from Mexico City to Santiago?

Travelers seeking maximum savings on their Mexico City to Santiago flight should consider departing on Thursday at noon when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Mexico City to Santiago?

Reviews of airlines servicing Santiago

See what other customers who have flown with Copa Airlines, LATAM Airlines, and Aeromexico from Mexico City to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.6

Good

1,531 reviews

Reviews

1 / 20

4.0

Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Copa Airlines

7.6

Good

1,531 reviews

Copa Airlines

7.6

Good

1,531 reviews

Reviews

1 / 20

4.0

Okay

Juan Pablo,Sep 2025

PTY - VVI

LATAM Airlines

7.5

Good

1,847 reviews

Copa Airlines

7.6

Good

1,531 reviews

Reviews

1 / 20

4.0

Okay

Juan Pablo,Sep 2025

PTY - VVI

Aeromexico

7.5

Good

1,701 reviews

Copa Airlines

7.6

Good

1,531 reviews

Reviews

1 / 20

4.0

Okay

Juan Pablo,Sep 2025

PTY - VVI

Avianca

6.7

Okay

2,436 reviews

Copa Airlines

7.6

Good

1,531 reviews

Reviews

1 / 20

4.0

Okay

Juan Pablo,Sep 2025

PTY - VVI

Related info for your journey

What airports do I use to fly from Mexico City to Santiago?
If you wish to fly to Santiago from Mexico City, then you need to book flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez. There is 1 flight from Benito Juarez (MEX) to Arturo Merino Benitez (SCL) per day to choose from. Flights to Santiago from Benito Juarez are available from 4 different airlines, which means you should have some options if you want to compare airfare deals. 8h 00m is how long a nonstop flight from Mexico City to Santiago Arturo Merino Benitez typically takes.
How popular is this Mexico City to Santiago flight route?
Within the past month, 5 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
How long is the flight from Mexico City to Santiago?
For as low as $546, Copa Airlines can have you in Santiago from Mexico City in 18h 41m. The distance between Mexico City and Santiago is about 4096 mi.
What are the cheapest airlines flying from Mexico City to Santiago round-trip?
Cheapflights users have booked flights from Mexico City to Santiago round-trip from $314. Other airlines that can offer you cheap pricing are Avianca, from $330, and Aeromexico, from $343. Users have found that Copa Airlines is 50% cheaper than the other options available to this destination.
What are the cheapest flights from Mexico City to Santiago?
While on average a flight from Mexico City to Santiago is generally $1,203, our data shows the cheapest flight currently is $530. When looking at the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), you can expect to pay $519 for that flight.
Can I find deals for flights from Mexico City to Santiago that include hotel bookings?
Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mexico City to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.
Can I find deals for business class flights from Mexico City to Santiago?
Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Mexico City to Santiago?
Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $752). Flying from Mexico City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Complete your trip

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Lastarria car rentals

Other flights to Santiago

Top 4 airlines flying from Mexico City to Santiago

Airline	Cheapest	Average	Flexibility	On-time
Copa Airlines	Cheapest$314	Average$677	FlexibilityNo cancel fee	On-time70%
Avianca	Cheapest$330	Average$587	FlexibilityNo cancel fee	On-time71%
Aeromexico	Cheapest$343	Average$781	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$491	Average$668	FlexibilityNo cancel fee	On-time81%

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$272+ Cheap flights from Mexico City (MEX) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Mexico City to Santiago with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in May or July, booked 90 days in advance, depart on a Thursday or Wednesday and return on a Thursday

Cheap flight deals from Mexico City to Santiago

Round-trip from

One-way from

Popular in

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Average price

Good round-trip deal

Good one-way deal

Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to SantiagoExplore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

What is the cheapest month to book a flight from Mexico City to Santiago?

What is the cheapest time of day to fly from MEX to SCL?

What is the cheapest day to fly from Mexico City to Santiago?

How much does it cost to fly round-trip from Mexico City to Santiago?

Weekly flight availability from Mexico City to Santiago

Reviews of airlines servicing Santiago

See what other customers who have flown with Copa Airlines, LATAM Airlines, and Aeromexico from Mexico City to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Mexico City to Santiago?

How popular is this Mexico City to Santiago flight route?

How long is the flight from Mexico City to Santiago?

What are the cheapest airlines flying from Mexico City to Santiago round-trip?

What are the cheapest flights from Mexico City to Santiago?

Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

How can I find direct flights from Mexico City to Santiago?

Can I find deals for business class flights from Mexico City to Santiago?

What is the cheapest month to book a flight from Mexico City to Santiago?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.

Top 4 airlines flying from Mexico City to Santiago

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Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.