$292+ Cheap flights from Mexico City (MEX) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
Apr 16 — Apr 231
Round-trip
1 adult, Economy
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Find cheap flights from Mexico City to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in May or November, booked 90 days in advance, depart on a Thursday or Wednesday and return on a Monday
Cheap flight deals from Mexico City to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mexico City to SantiagoExplore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/214:50 pm
MEX
- SCL
2 stops14h 49m
Multiple Airlines
Fri 4/104:56 am
SCL
- MEX
1 stop32h 14m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$550
This Mytrip deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/94:55 pm
MEX
- SCL
2 stops19h 36m
Multiple Airlines
Wed 4/158:31 pm
SCL
- MEX
2 stops28h 29m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$594
This Avianca deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2211:10 pm
MEX
- SCL
1 stop27h 20m
Avianca
Wed 3/254:25 pm
SCL
- MEX
1 stop13h 35m
Avianca
Deal found 3/12![Avianca logo]()
$602
This Gotogate deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:00 am
MEX
- SCL
1 stop16h 30m
Avianca
Fri 4/103:20 pm
SCL
- MEX
1 stop13h 45m
Avianca
Deal found 3/12![Avianca logo]()
$616
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/275:50 am
MEX
- SCL
1 stop14h 53m
Copa Airlines
Wed 5/134:09 am
SCL
- MEX
1 stop12h 21m
Copa Airlines
Deal found 3/13![Copa Airlines logo]()
$618
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/269:50 am
MEX
- SCL
1 stop31h 33m
Copa Airlines
Sun 5/311:17 am
SCL
- MEX
1 stop15h 43m
Copa Airlines
Deal found 3/12![Copa Airlines logo]()
$625
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/225:00 am
MEX
- SCL
1 stop16h 30m
Avianca
Fri 4/103:20 pm
SCL
- MEX
1 stop13h 45m
Avianca
Deal found 3/12![Avianca logo]()
$632
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/113:30 pm
MEX
- SCL
1 stop33h 30m
Copa Airlines
Sat 4/1811:25 am
SCL
- MEX
1 stop12h 35m
Copa Airlines
Deal found 3/14![Copa Airlines logo]()
$639
This Mytrip deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:55 am
MEX
- SCL
2 stops21h 22m
Multiple Airlines
Wed 4/223:30 pm
SCL
- MEX
2 stops33h 30m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$640
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1210:00 pm
MEX
- SCL
1 stop13h 30m
Multiple Airlines
Sun 4/194:56 am
SCL
- MEX
1 stop32h 14m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$646
Best flights from Mexico City to SantiagoDiscover carefully curated flight deals from Mexico City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
Discover carefully curated flight deals from Mexico City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
This Copa Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:50 am
MEX
- SCL
1 stop11h 33m
Copa Airlines
Wed 5/204:09 am
SCL
- MEX
1 stop16h 56m
Copa Airlines
Deal found 3/13![Copa Airlines logo]()
$653
This Copa Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:10 am
MEX
- SCL
1 stop15h 13m
Copa Airlines
Mon 5/114:09 am
SCL
- MEX
1 stop19h 56m
Copa Airlines
Deal found 3/13![Copa Airlines logo]()
$653
This Copa Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:50 am
MEX
- SCL
1 stop15h 36m
Copa Airlines
Tue 6/22:22 am
SCL
- MEX
1 stop11h 48m
Copa Airlines
Deal found 3/13![Copa Airlines logo]()
$668
This Copa Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:20 am
MEX
- SCL
1 stop20h 06m
Copa Airlines
Fri 5/12:22 am
SCL
- MEX
1 stop14h 08m
Copa Airlines
Deal found 3/16![Copa Airlines logo]()
$684
This Copa Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:50 am
MEX
- SCL
1 stop15h 36m
Copa Airlines
Sun 4/192:30 am
SCL
- MEX
1 stop21h 35m
Copa Airlines
Deal found 3/14![Copa Airlines logo]()
$684
This Copa Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:20 am
MEX
- SCL
1 stop16h 03m
Copa Airlines
Sat 6/62:22 am
SCL
- MEX
1 stop14h 08m
Copa Airlines
Deal found 3/16![Copa Airlines logo]()
$684
This Copa Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:50 am
MEX
- SCL
1 stop11h 33m
Copa Airlines
Sat 4/1812:46 am
SCL
- MEX
1 stop20h 19m
Copa Airlines
Deal found 3/12![Copa Airlines logo]()
$725
This Copa Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/31:10 pm
MEX
- SCL
1 stop13h 49m
Copa Airlines
Tue 9/1512:22 pm
SCL
- MEX
1 stop15h 38m
Copa Airlines
Deal found 3/12![Copa Airlines logo]()
$736
Last-minute flights from Mexico City to SantiagoDiscover last-minute flight deals from Mexico City to Santiago. Data last updated March 17, 2026 and is based on user searches.
Discover last-minute flight deals from Mexico City to Santiago. Data last updated March 17, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/214:50 pm
MEX
- SCL
2 stops14h 49m
Multiple Airlines
Fri 4/104:56 am
SCL
- MEX
1 stop32h 14m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$550
This Gotogate deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:00 am
MEX
- SCL
1 stop16h 30m
Avianca
Fri 4/103:20 pm
SCL
- MEX
1 stop13h 45m
Avianca
Deal found 3/12![Avianca logo]()
$616
This Avianca deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2211:10 pm
MEX
- SCL
1 stop27h 20m
Avianca
Wed 3/254:25 pm
SCL
- MEX
1 stop13h 35m
Avianca
Deal found 3/12![Avianca logo]()
$602
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/225:00 am
MEX
- SCL
1 stop16h 30m
Avianca
Fri 4/103:20 pm
SCL
- MEX
1 stop13h 45m
Avianca
Deal found 3/12![Avianca logo]()
$632
This Mytrip deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/94:55 pm
MEX
- SCL
2 stops19h 36m
Multiple Airlines
Wed 4/158:31 pm
SCL
- MEX
2 stops28h 29m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$594
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/113:30 pm
MEX
- SCL
1 stop33h 30m
Copa Airlines
Sat 4/1811:25 am
SCL
- MEX
1 stop12h 35m
Copa Airlines
Deal found 3/14![Copa Airlines logo]()
$639
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1210:00 pm
MEX
- SCL
1 stop13h 30m
Multiple Airlines
Sun 4/194:56 am
SCL
- MEX
1 stop32h 14m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$646
This Mytrip deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:55 am
MEX
- SCL
2 stops21h 22m
Multiple Airlines
Wed 4/223:30 pm
SCL
- MEX
2 stops33h 30m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$640
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/269:50 am
MEX
- SCL
1 stop31h 33m
Copa Airlines
Sun 5/311:17 am
SCL
- MEX
1 stop15h 43m
Copa Airlines
Deal found 3/12![Copa Airlines logo]()
$625
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/275:50 am
MEX
- SCL
1 stop14h 53m
Copa Airlines
Wed 5/134:09 am
SCL
- MEX
1 stop12h 21m
Copa Airlines
Deal found 3/13![Copa Airlines logo]()
$618
One-way flights from Mexico City to SantiagoSearch for one-way flight options from Mexico City to Santiago. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
Search for one-way flight options from Mexico City to Santiago. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
This Copa Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/249:25 am
MEX
- SCL
1 stop14h 52m
Copa Airlines
Deal found 3/13![Copa Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/94:55 am
MEX
- SCL
2 stops31h 36m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:55 am
MEX
- SCL
2 stops21h 16m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:55 pm
MEX
- SCL
2 stops19h 36m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$301
This Copa Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:50 am
MEX
- SCL
1 stop14h 53m
Copa Airlines
Deal found 3/13![Copa Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:55 pm
MEX
- SCL
2 stops33h 16m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$331
This Mytrip deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/510:00 pm
MEX
- SCL
1 stop21h 05m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$339
This Copa Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/35:50 am
MEX
- SCL
1 stop11h 33m
Copa Airlines
Deal found 3/13![Copa Airlines logo]()
$346
This KAYAK deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/163:30 pm
MEX
- SCL
1 stop25h 53m
Copa Airlines
Deal found 3/12![Copa Airlines logo]()
$349
This Cheapflightsfares deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1612:40 am
MEX
- SCL
1 stop20h 40m
Avianca
Deal found 3/17![Avianca logo]()
$352
This Super.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:55 am
MEX
- SCL
1 stop16h 25m
Avianca
Deal found 3/15![Avianca logo]()
$366
Find flight deals from Mexico City to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $588 (Mytrip) |
One-way from | $292 (Copa Airlines) |
Popular in | December |
Cheapest in | May |
Average price | $626 |
Good round-trip deal | $733 or less |
Good one-way deal | $692 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Tue 5/5
5:50 am-7:23 pm
1 stop11h 33m
Santiago Arturo Merino Benitez
Wed 5/20
4:09 am-7:05 pm
1 stop16h 56m
$653
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Wed 5/6
2:10 am-7:23 pm
1 stop15h 13m
Santiago Arturo Merino Benitez
Mon 5/11
4:09 am-10:05 pm
1 stop19h 56m
$653
Quickest round-trip
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Tue 5/26
5:50 am-11:26 pm
1 stop15h 36m
Santiago Arturo Merino Benitez
Tue 6/2
2:22 am-12:10 pm
1 stop11h 48m
$668
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Thu 4/23
1:20 am-11:26 pm
1 stop20h 06m
Santiago Arturo Merino Benitez
Fri 5/1
2:22 am-2:30 pm
1 stop14h 08m
$684
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Sat 4/11
5:50 am-11:26 pm
1 stop15h 36m
Santiago Arturo Merino Benitez
Sun 4/19
2:30 am-10:05 pm
1 stop21h 35m
$684
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Tue 6/2
1:20 am-7:23 pm
1 stop16h 03m
Santiago Arturo Merino Benitez
Sat 6/6
2:22 am-2:30 pm
1 stop14h 08m
$684
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Mon 4/6
5:50 am-7:23 pm
1 stop11h 33m
Santiago Arturo Merino Benitez
Sat 4/18
12:46 am-7:05 pm
1 stop20h 19m
$725
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Thu 9/3
1:10 pm-4:59 am
1 stop13h 49m
Santiago Arturo Merino Benitez
Tue 9/15
12:22 pm-1:00 am
1 stop15h 38m
$736
Cheapest one-way
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Fri 5/8
9:50 am-11:26 pm
1 stop11h 36m
$325
Mexico CitySantiago
MEX - SCL
MEXSCL
Mexico City Benito Juarez
Sat 5/16
2:10 am-10:43 pm
1 stop18h 33m
$325
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Mexico City to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Santiago in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Mexico City-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Mexico City-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Mexico City-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Mexico City-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Mexico City to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
MEX-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mexico City to Santiago
Prices
Airlines
Delays
How far ahead should I book a flight from Mexico City to Santiago?
Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on March 13, 2026.
The best time to book flights from Mexico City to Santiago is 90 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Mexico City to Santiago?
Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $264). Flying from Mexico City to Santiago in June is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MEX to SCL?
Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 17, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mexico City to Santiago as you normally would.
How often are flights from Mexico City to Santiago delayed?
About 10% of weekly flights between Mexico City and Santiago have experienced delays in the past year, with the average delay time being 134 minutes.
What is the most punctual flight time for Mexico City to Santiago flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the evening tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Wednesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Mexico City to Santiago flights?
Over the last year, LATAM Airlines have had the lowest number of delays on this route, with just 5% of flights being delayed.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated March 17, 2026.
See what other customers who have flown with Copa Airlines,LATAM Airlines, andAeromexico from Mexico City to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Crew
8.1
Entertainment
6.8
Food
6.8
Overall
7.5
Comfort
7.4
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Boarding
7.8
Crew
8.1
Entertainment
6.8
Food
6.8
Overall
7.5
Comfort
7.4
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Boarding
7.8
Crew
8.1
Entertainment
6.8
Food
6.8
Overall
7.5
Comfort
7.4
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Boarding
7.8
Crew
8.1
Entertainment
6.8
Food
6.8
Overall
7.5
Comfort
7.4
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Boarding
7.8
Crew
8.1
Entertainment
6.8
Food
6.8
Overall
7.5
Comfort
7.4
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Related info for your journey
Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mexico City to Santiago by cabin class
Find flights from Mexico City to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mexico City and Santiago flights
Browse other Mexico City and Santiago flight options. Last updated on March 17, 2026.
Other flights from Mexico City
Browse through other flights departing from Mexico City. Flights are based on user searches made on Cheapflights and were last updated on March 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 17, 2026.
Top 4 airlines flying from Mexico City to Santiago
Discover the top 4 airlines that operate flights from Mexico City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$284 | Average$608 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$423 | Average$563 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$461 | Average$594 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$465 | Average$671 | FlexibilityNo cancel fee | On-time81% |