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$305+ Cheap flights from Indianapolis (IND) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
IND — SCL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Indianapolis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Indianapolis (IND) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$751
(LATAM Airlines)

One-way from

$305
(Kiwi.com)

Popular in

December

Cheapest in

November

Average price

$963
From Indianapolis to Santiago Arturo Merino Benitez
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One-way flight from Indianapolis to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 3% potential increase in price ($36 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Indianapolis to Santiago

Cheapest flights from Indianapolis to Santiago
Explore the most affordable flight options available from Indianapolis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/34:48 pmIND - SCL
1 stop12h 52mLATAM Airlines
Mon 11/1711:40 pmSCL - IND
1 stop14h 36mLATAM Airlines
Deal found 9/9$751
This Trip.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/75:30 amIND - SCL
2 stops24h 25mMultiple Airlines
Sun 10/1212:10 amSCL - IND
2 stops23h 54mMultiple Airlines
Deal found 9/11$757
This LATAM Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/712:52 pmIND - SCL
1 stop15h 53mLATAM Airlines
Mon 10/1310:50 pmSCL - IND
1 stop18h 29mLATAM Airlines
Deal found 9/11$767
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:45 amIND - SCL
3 stops23h 00mMultiple Airlines
Sat 10/43:30 pmSCL - IND
3 stops27h 05mMultiple Airlines
Deal found 9/11$768
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/285:45 amIND - SCL
1 stop24h 15mMultiple Airlines
Thu 10/211:00 amSCL - IND
2 stops34h 04mMultiple Airlines
Deal found 9/11$771
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/285:45 amIND - SCL
1 stop24h 15mMultiple Airlines
Wed 10/14:47 amSCL - IND
2 stops33h 16mMultiple Airlines
Deal found 9/11$773
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/311:28 amIND - SCL
1 stop18h 12mDelta
Sun 11/1612:55 amSCL - IND
2 stops18h 36mDelta
Deal found 9/9$784
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/285:45 amIND - SCL
1 stop24h 15mMultiple Airlines
Fri 10/34:35 amSCL - IND
2 stops31h 18mMultiple Airlines
Deal found 9/11$787
This Mytrip deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/155:45 amIND - SCL
3 stops32h 00mMultiple Airlines
Sun 9/285:51 amSCL - IND
3 stops30h 02mMultiple Airlines
Deal found 9/10$790

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indianapolis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Indianapolis to Santiago that are best for you.

Fly from

Indianapolis

Fly to

Santiago

Route

Depart

Return

Price

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Tue 12/9

5:34 pm-7:40 am

1 stop12h 06m

Santiago Arturo Merino Benitez

Tue 12/16

11:40 pm-12:17 pm

1 stop14h 37m

$751

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Mon 11/3

11:28 am-7:40 am

1 stop18h 12m

Santiago Arturo Merino Benitez

Mon 11/17

11:40 pm-12:16 pm

1 stop14h 36m

$767

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Tue 12/9

10:09 am-4:30 am

2 stops16h 21m

Santiago Arturo Merino Benitez

Tue 12/16

6:30 pm-10:29 am

2 stops17h 59m

$784

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Mon 11/3

11:28 am-7:40 am

1 stop18h 12m

Santiago Arturo Merino Benitez

Sun 11/16

12:55 am-5:31 pm

2 stops18h 36m

$784

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Mon 9/29

5:00 am-3:35 am

3 stops45h 35m

$305

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Tue 9/30

5:45 am-6:55 am

2 stops24h 10m

$352

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Fri 10/10

8:51 pm-10:15 pm

3 stops24h 24m

$412

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Fri 10/10

12:52 pm-5:45 am

1 stop15h 53m

$580

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Tue 9/30

4:40 pm-7:00 am

1 stop13h 20m

$593

IndianapolisSantiago

IND - SCL

INDSCL

Indianapolis

Mon 9/29

4:40 pm-7:00 am

1 stop13h 20m

$593

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 14 results
1
2

Best time to book a flight from Indianapolis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indianapolis to Santiago

What is the cheapest month to book a flight from Indianapolis to Santiago?

Currently, April is the cheapest month in which you can book a flight from Indianapolis to Santiago (average of $752). Flying from Indianapolis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SCL?

Find hourly flight availability from Indianapolis to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

One of the essential ways to save on airfare from Indianapolis to Santiago is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 21% on airfare.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 11, 2025.
See what other customers who have flown with Delta and LATAM Airlines from Indianapolis to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,847 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Indianapolis to Santiago?

    A quick flight from Indianapolis to Santiago can take about 12h 06m. LATAM Airlines provides one of the quickest options available for as low as $751. The distance between Indianapolis and Santiago is about 5144 mi.

  • What are the cheapest airlines flying from Indianapolis to Santiago round-trip?

    According to our current data, LATAM Airlines ($803), and Delta ($823) offers the cheapest pricing from Indianapolis to Santiago. LATAM Airlines is 18% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Indianapolis to Santiago that include hotel bookings?

    Yes. In addition to deals on Indianapolis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to Santiago.

  • Can I find deals for business class flights from Indianapolis to Santiago?

    Yes. Cheapflights offers flight deals from Indianapolis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Indianapolis to Santiago (average of $752). Flying from Indianapolis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Indianapolis to Santiago

Discover the top 2 airlines that operate flights from Indianapolis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$803Average$994FlexibilityNo cancel feeOn-time81%
DeltaCheapest$823Average$1,006FlexibilityNo cancel feeOn-timeN/A

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