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$266+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — SCL
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find flight deals from Detroit to Santiago

Cheapest flights from Detroit to Santiago
Explore the most affordable flight options available from Detroit to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1012:12 pmDTW - SCL
3 stops32h 03mMultiple Airlines
Wed 12/1712:30 pmSCL - DTW
2 stops23h 30mMultiple Airlines
Deal found 10/26$759
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:00 amDTW - SCL
3 stops28h 15mMultiple Airlines
Thu 12/181:35 amSCL - DTW
3 stops25h 07mMultiple Airlines
Deal found 10/28$771
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/157:08 amDTW - SCL
3 stops29h 32mMultiple Airlines
Sat 1/179:29 pmSCL - DTW
3 stops36h 50mMultiple Airlines
Deal found 10/26$794
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1011:05 amDTW - SCL
2 stops19h 45mUnited Airlines
Wed 12/1710:45 pmSCL - DTW
1 stop19h 04mUnited Airlines
Deal found 10/26$864
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:23 pmDTW - SCL
2 stops26h 52mMultiple Airlines
Wed 1/76:00 amSCL - DTW
1 stop36h 06mMultiple Airlines
Deal found 10/27$884
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:40 amDTW - SCL
1 stop25h 45mAmerican Airlines
Mon 12/2911:15 pmSCL - DTW
1 stop17h 28mAmerican Airlines
Deal found 10/28$926

Cheap flight deals from Detroit to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$645
(Mytrip)

One-way from

$266
(Kiwi.com)

Popular in

October

Cheapest in

November

Average price

$1,308
Provider with most accurate pricing for Detroit Metropolitan Wayne County-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Detroit Metropolitan Wayne County-Santiago Arturo Merino Benitez flights.
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From Detroit Metropolitan Wayne County to Santiago Arturo Merino Benitez
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One-way flight from Detroit Metropolitan Wayne County to Santiago Arturo Merino Benitez
Search Deals
High demand for flights, 3% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Santiago that are best for you.

Fly from

Detroit

Fly to

Santiago

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 1/6

5:50 am-10:15 pm

3 stops38h 25m

Santiago Arturo Merino Benitez

Tue 1/20

12:35 pm-2:09 pm

2 stops27h 34m

$645

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 2/20

12:29 pm-5:25 am

3 stops38h 56m

Santiago Arturo Merino Benitez

Mon 3/2

9:10 pm-2:09 pm

2 stops18h 59m

$793

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 12/10

11:05 am-8:50 am

2 stops19h 45m

Santiago Arturo Merino Benitez

Wed 12/17

10:45 pm-3:49 pm

1 stop19h 04m

$864

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 12/10

11:48 am-7:45 am

1 stop17h 57m

Santiago Arturo Merino Benitez

Wed 12/17

11:15 pm-6:35 pm

1 stop21h 20m

$864

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/20

3:37 pm-9:05 am

2 stops16h 28m

Santiago Arturo Merino Benitez

Thu 3/26

9:15 pm-2:47 pm

2 stops18h 32m

$909

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/20

6:15 pm-9:55 pm

2 stops26h 40m

Santiago Arturo Merino Benitez

Thu 3/26

7:25 am-5:35 pm

3 stops35h 10m

$925

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 12/15

10:57 am-8:55 am

2 stops19h 58m

Santiago Arturo Merino Benitez

Sat 1/17

11:55 pm-4:35 pm

2 stops18h 40m

$1,009

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 11/10

8:00 pm-4:00 am

2 stops30h 00m

$266

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 11/12

3:12 pm-3:35 am

3 stops34h 23m

$269

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 11/11

7:17 pm-10:15 pm

3 stops48h 58m

$283

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 13 results
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Compare providers for flights from Detroit to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Santiago in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Detroit Metropolitan Wayne County Airport-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Santiago

What is the cheapest time of day to fly from DTW to SCL?

Find hourly flight availability from Detroit to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 18% on flights from Detroit Metropolitan Wayne County Airport to Santiago by exploring options for tickets in the evening.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 28, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and American Airlines from Detroit Metropolitan Wayne County Airport to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,995 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,995 reviews
Delta
7.9
Good
7,995 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
LATAM Airlines
7.5
Good
1,871 reviews
Delta
7.9
Good
7,995 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,995 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Air Canada
7.1
Good
10,370 reviews
Delta
7.9
Good
7,995 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to Santiago round-trip?

    According to our current data, Air Canada ($684), LATAM Airlines ($733), and Delta ($768) offers the cheapest pricing from Detroit Metropolitan Wayne County Airport to Santiago. Users have found that Air Canada is 40% cheaper than the other options available to this destination.

  • Can I find deals for flights from Detroit to Santiago that include hotel bookings?

    Yes. In addition to deals on Detroit to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Santiago.

  • Can I find deals for business class flights from Detroit to Santiago?

    Yes. Cheapflights offers flight deals from Detroit to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Detroit to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Detroit to Easter Island flights

Top 4 airlines flying from Detroit to Santiago

Discover the top 4 airlines that operate flights from Detroit to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
Air CanadaCheapest$684Average$946FlexibilityNo cancel feeOn-time67%
LATAM AirlinesCheapest$733Average$1,418FlexibilityNo cancel feeOn-time81%
DeltaCheapest$768Average$1,273FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$822Average$1,047FlexibilityNo cancel feeOn-time71%

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