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$116+ Cheap flights from Cusco (CUZ) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
CUZ — SCL
feb. 20 — feb. 271
vie. 2/20
vie. 2/27
1 adult, Economy
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Cheap flight deals from Cuzco to Santiago

Cheapest flights from Cuzco to Santiago
Explore the most affordable flight options available from Cuzco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 21, 2026.

This FlightHub deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/92:05 pm
CUZ
-
SCL
1 stop15h 35m
Sky Airline
dom. 4/128:15 pm
SCL
-
CUZ
1 stop11h 20m
Sky Airline
Deal found 1/20$274
This FlightHub deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/95:05 pm
CUZ
-
SCL
1 stop10h 06m
JetSMART
dom. 4/124:56 am
SCL
-
CUZ
1 stop12h 04m
JetSMART
Deal found 1/21$275
This FlightHub deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/99:30 am
CUZ
-
SCL
Nonstop3h 20m
LATAM Airlines
dom. 4/124:50 pm
SCL
-
CUZ
1 stop7h 35m
LATAM Airlines
Deal found 1/20$300
This FlightHub deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/97:05 am
CUZ
-
SCL
2 stops26h 55m
Sky Airline
mié. 3/111:35 am
SCL
-
CUZ
2 stops21h 30m
Sky Airline
Deal found 1/20$308
This CheapOair deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/911:40 am
CUZ
-
SCL
2 stops22h 20m
Multiple Airlines
jue. 3/123:45 pm
SCL
-
CUZ
Nonstop3h 30m
Multiple Airlines
Deal found 1/20$363
This FlightHub deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/94:17 pm
CUZ
-
SCL
1 stop10h 57m
JetSMART
vie. 3/135:59 am
SCL
-
CUZ
1 stop16h 22m
JetSMART
Deal found 1/21$399
This JetSMART deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/1010:02 pm
CUZ
-
SCL
1 stop29h 12m
JetSMART
sáb. 3/145:59 am
SCL
-
CUZ
1 stop26h 27m
JetSMART
Deal found 1/20$406

Find flight deals from Cuzco to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Cuzco (CUZ) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 21, 2026.

Most accurate provider

Justfly.com
3 stars

Most trusted provider

Justfly.com
3 stars

Round-trip from

$274
(FlightHub)

One-way from

$116
(JetSMART)

Popular in

June

Cheapest in

December

Average price

$364

Good one-way deal

$256 or less
Provider with most accurate pricing for Cusco Velazco Astete-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cusco Velazco Astete-Santiago Arturo Merino Benitez flights.
Search Deals
From Cusco Velazco Astete to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Cusco Velazco Astete to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($50 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a one-way flight from Cusco Velazco Astete to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cuzco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 21, 2026.
Use the filters below to find and compare flights from Cusco to Santiago that are best for you.

Fly from

Cuzco

Fly to

Santiago

Route

Depart

Return

Price

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

jue. 4/9

2:05 pm-6:40 am

1 stop15h 35m

Santiago Arturo Merino Benitez

dom. 4/12

8:15 pm-6:35 am

1 stop11h 20m

$274

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

jue. 4/9

9:30 am-1:50 pm

Nonstop3h 20m

Santiago Arturo Merino Benitez

dom. 4/12

4:50 pm-11:25 pm

1 stop7h 35m

$300

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

lun. 3/9

7:05 am-12:00 pm

2 stops26h 55m

Santiago Arturo Merino Benitez

mié. 3/11

1:35 am-9:05 pm

2 stops21h 30m

$308

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

lun. 3/9

4:17 pm-5:14 am

1 stop10h 57m

Santiago Arturo Merino Benitez

vie. 3/13

5:59 am-8:21 pm

1 stop16h 22m

$399

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

mar. 4/21

4:35 pm-3:56 am

1 stop10h 21m

$116

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

mar. 6/16

5:20 pm-3:56 am

1 stop9h 36m

$116

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

jue. 4/16

9:45 pm-11:00 am

2 stops12h 15m

$128

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

jue. 4/9

7:10 am-11:00 am

2 stops26h 50m

$137

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

jue. 4/16

9:30 am-1:50 pm

Nonstop3h 20m

$138

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

vie. 5/1

2:05 pm-11:00 am

2 stops19h 55m

$139

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 12 results
1
2

Compare providers for flights from Cuzco to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Cuzco to Santiago in January.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
Justfly.comPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Cusco-Santiago flights, users find the pricing of Justfly.com to be most consistent on Cheapflights vs. Justfly.com Users can find the same prices on Cusco-Santiago flight deals on Cheapflights vs. Justfly.com >95% of the time. Price accuracy is based on data collected from Cusco-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Cusco-Santiago flights, Cheapflights users trust Justfly.com the most. Justfly.com has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Cusco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Cuzco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Cuzco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cusco to Santiago

How far ahead should I book a flight from Cusco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Cuzco to Santiago. Price data was last updated on January 16, 2026.

To ensure you get the cheapest price possible for a flight from Cusco to Santiago, you should look to book at least 51 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Cusco to Santiago?

Currently, October is the cheapest month in which you can book a flight from Cusco to Santiago (average of $114). Flying from Cusco to Santiago in July is currently the most expensive (average of $249). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CUZ to SCL?

Find hourly flight availability from Cuzco to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated enero 21, 2026.

When flying from Cusco to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated enero 21, 2026.
Read through reviews of airlines operating flights from Cusco to Santiago, such as LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,913 reviews

Crew

8.0

Overall

7.5

Boarding

7.6

Comfort

7.3

Entertainment

7.0

Food

6.7

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
LATAM Airlines
7.5
Good
1,913 reviews
LATAM Airlines
7.5
Good
1,913 reviews

Crew

8.0

Overall

7.5

Boarding

7.6

Comfort

7.3

Entertainment

7.0

Food

6.7

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken

Related info for your journey

Find useful and relevant information for your journey from Cuzco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Cusco to Santiago?

    A quick flight from Cusco to Santiago can take about 15h 35m. Sky Airline provides one of the quickest options available for as low as $274. The distance from Cusco to Santiago is about 1373 mi.

  • What is the cheapest airline to fly from Cusco to Santiago round-trip?

    Flying on LATAM Airlines is currently your cheapest option to Santiago, with prices starting at $280. Users have found that LATAM Airlines is 11% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Cusco to Santiago one-way?

    To fly one-way, consider booking your trip with JetSMART, which is currently one of the cheapest options available, starting at $93. Sky Airline flights start at $113 while deals on LATAM Airlines start at $145 one-way.

  • What are the cheapest flights from Cusco to Santiago?

    While on average a flight from Cusco to Santiago is generally $282, our data shows the cheapest flight currently is $145. When looking at the most popular route, (Cusco Velazco Astete - Santiago Arturo Merino Benitez), you can expect to pay $229 for that flight.

  • Can I find deals for flights from Cuzco to Santiago that include hotel bookings?

    Yes. In addition to deals on Cuzco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cuzco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cuzco to Santiago.

  • Can I find deals for business class flights from Cuzco to Santiago?

    Yes. Cheapflights offers flight deals from Cuzco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cusco to Santiago?

    Currently, October is the cheapest month in which you can book a flight from Cusco to Santiago (average of $114). Flying from Cusco to Santiago in July is currently the most expensive (average of $249). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Cuzco to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Lima to Santiago flights
Arequipa to Santiago flights
Lima to Punta Arenas flights

Top airline flying from Cuzco to Santiago

Discover the top airline that operate flights from Cuzco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$280Average$470FlexibilityNo cancel feeOn-time81%

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