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$110+ Cheap flights from Cusco (CUZ) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel.
CUZ — SCL
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Cheap flight deals from Cuzco to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Cuzco (CUZ) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$252
(Trip.com)

One-way from

$110
(LATAM Airlines)

Popular in

June

Cheapest in

October

Average price

$297

Good one-way deal

$177 or less
Provider with most accurate pricing for Cusco Velazco Astete-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Cusco Velazco Astete-Santiago Arturo Merino Benitez flights.
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From Cusco Velazco Astete to Santiago Arturo Merino Benitez
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One-way flight from Cusco Velazco Astete to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 14% potential increase in price ($55 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Price to beat on a one-way flight from Cusco Velazco Astete to Santiago Arturo Merino Benitez.
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Find flight deals from Cuzco to Santiago

Cheapest flights from Cuzco to Santiago
Explore the most affordable flight options available from Cuzco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Booking.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/154:22 pmCUZ - SCL
1 stop10h 52mMultiple Airlines
Wed 12/3111:05 pmSCL - CUZ
1 stop24h 00mMultiple Airlines
Deal found 11/11$269
This Booking.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/158:30 pmCUZ - SCL
2 stops13h 45mSky Airline
Wed 12/3111:05 pmSCL - CUZ
1 stop24h 00mSky Airline
Deal found 11/11$286
This Trip.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/251:27 pmCUZ - SCL
1 stop13h 47mMultiple Airlines
Wed 12/3111:05 pmSCL - CUZ
1 stop24h 00mMultiple Airlines
Deal found 11/11$296
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:45 pmCUZ - SCL
1 stop14h 55mSky Airline
Thu 1/112:35 pmSCL - CUZ
1 stop20h 45mSky Airline
Deal found 11/11$313
This CheapOair deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/129:30 amCUZ - SCL
Nonstop3h 15mMultiple Airlines
Mon 11/179:05 pmSCL - CUZ
1 stop11h 25mMultiple Airlines
Deal found 11/11$314
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:30 amCUZ - SCL
Nonstop3h 15mLATAM Airlines
Thu 1/18:10 amSCL - CUZ
1 stop9h 10mLATAM Airlines
Deal found 11/11$333
This Trip.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/68:30 pmCUZ - SCL
2 stops13h 45mSky Airline
Wed 12/109:05 pmSCL - CUZ
1 stop12h 15mSky Airline
Deal found 11/13$335
This Trip.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/128:30 pmCUZ - SCL
1 stop16h 10mSky Airline
Mon 11/179:05 pmSCL - CUZ
1 stop11h 25mSky Airline
Deal found 11/11$337

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cuzco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Cusco to Santiago that are best for you.

Fly from

Cuzco

Fly to

Santiago

Route

Depart

Return

Price

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Mon 12/15

4:22 pm-5:14 am

1 stop10h 52m

Santiago Arturo Merino Benitez

Wed 12/31

11:05 pm-9:05 pm

1 stop24h 00m

$269

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 4/9

9:30 am-1:50 pm

Nonstop3h 20m

Santiago Arturo Merino Benitez

Sat 4/11

12:35 am-4:15 pm

2 stops16h 40m

$270

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 4/9

11:10 am-11:15 am

2 stops23h 05m

Santiago Arturo Merino Benitez

Sun 4/12

8:15 pm-5:50 pm

1 stop22h 35m

$279

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 3/19

5:00 am-5:55 pm

1 stop10h 55m

$110

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Sun 4/5

11:35 pm-5:35 pm

1 stop17h 00m

$110

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 3/12

12:10 pm-10:15 pm

1 stop8h 05m

$127

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Sun 4/5

7:05 am-5:50 am

1 stop21h 45m

$128

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 3/19

8:57 pm-10:39 am

1 stop11h 42m

$129

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 4/9

7:05 am-11:15 am

2 stops27h 10m

$138

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Wed 12/24

4:45 pm-12:15 pm

2 stops17h 30m

$138

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 11 results
1
2

Compare providers for flights from Cuzco to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Cuzco to Santiago in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Cusco-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Cusco-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Cusco-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Cusco-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Cusco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Cuzco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Cuzco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cusco to Santiago

How far ahead should I book a flight from Cusco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Cuzco to Santiago. Price data was last updated on November 7, 2025.

To ensure you get the cheapest price possible for a flight from Cusco to Santiago, you should look to book at least 51 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Cusco to Santiago?

Currently, October is the cheapest month in which you can book a flight from Cusco to Santiago (average of $113). Flying from Cusco to Santiago in July is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CUZ to SCL?

Find hourly flight availability from Cuzco to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

When flying from Cusco to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Cusco to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated November 13, 2025.
Read through reviews of airlines operating flights from Cusco to Santiago, such as LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,876 reviews

Entertainment

7.0

Crew

8.0

Food

6.7

Boarding

7.6

Comfort

7.3

Overall

7.5

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!
LATAM Airlines
7.5
Good
1,876 reviews
LATAM Airlines
7.5
Good
1,876 reviews

Entertainment

7.0

Crew

8.0

Food

6.7

Boarding

7.6

Comfort

7.3

Overall

7.5

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!

Related info for your journey

Find useful and relevant information for your journey from Cuzco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Cusco to Santiago?

    Booking a flight from Cusco Velazco Astete (CUZ) to Santiago Arturo Merino Benitez (SCL) is your only option if you wish to fly from Cusco to Santiago. On a typical day, there is 1 flight from Velazco Astete to Arturo Merino Benitez, all of which are around 3h 15m for a nonstop flight. You can also purchase a plane ticket from 1 airline when you book a flight from Velazco Astete to Santiago.

  • What is the cheapest airline to fly from Cusco to Santiago round-trip?

    Flying on LATAM Airlines is currently your cheapest option to Santiago, with prices starting at $292. Users have found that LATAM Airlines is 7% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Cusco to Santiago one-way?

    To fly one-way, consider booking your trip with LATAM Airlines, which is currently one of the cheapest options available, starting at $110. Sky Airline flights start at $127 while deals on JetSMART start at $129 one-way.

  • What are the cheapest flights from Cusco to Santiago?

    While on average a flight from Cusco to Santiago is generally $202, our data shows the cheapest flight currently is $147. When looking at the most popular route, (Cusco Velazco Astete - Santiago Arturo Merino Benitez), you can expect to pay $369 for that flight.

  • Can I find deals for flights from Cuzco to Santiago that include hotel bookings?

    Yes. In addition to deals on Cuzco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cuzco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cuzco to Santiago.

  • Can I find deals for business class flights from Cuzco to Santiago?

    Yes. Cheapflights offers flight deals from Cuzco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cusco to Santiago?

    Currently, October is the cheapest month in which you can book a flight from Cusco to Santiago (average of $113). Flying from Cusco to Santiago in July is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Cuzco to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Cuzco to Santiago

Discover the top airline that operate flights from Cuzco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$292Average$469FlexibilityNo cancel feeOn-time81%

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