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$132+ Cheap flights from Cusco (CUZ) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
CUZ — SCL
oct. 16 — oct. 231
jeu. 10/16
jeu. 10/23
1 adult, Economy
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Cheapflights Tip: The best prices from Cusco Velazco Astete to Santiago Arturo Merino Benitez are usually found in December or October, booked 51 days in advance, depart on a Monday or Tuesday and return on a Saturday

Cheap flight deals from Cuzco to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Cuzco (CUZ) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septembre 16, 2025.

Round-trip from

$265
(Trip.com)

One-way from

$132
(Trip.com)

Popular in

June

Cheapest in

December

Average price

$285

Good one-way deal

$192 or less
From Cusco Velazco Astete to Santiago Arturo Merino Benitez
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One-way flight from Cusco Velazco Astete to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 15% potential increase in price ($56 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a one-way flight from Cusco Velazco Astete to Santiago Arturo Merino Benitez.
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Find flight deals from Cuzco to Santiago

Cheapest flights from Cuzco to Santiago
Explore the most affordable flight options available from Cuzco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septembre 16, 2025.

This Trip.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 10/2911:02 amCUZ - SCL
1 stop16h 12mJetSMART
mer. 11/55:59 amSCL - CUZ
1 stop8h 07mJetSMART
Deal found 9/14$265
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 10/2912:47 pmCUZ - SCL
1 stop14h 27mMultiple Airlines
mar. 11/41:35 amSCL - CUZ
2 stops20h 10mMultiple Airlines
Deal found 9/14$274
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 10/1510:40 pmCUZ - SCL
1 stop14h 20mLATAM Airlines
mer. 10/225:55 pmSCL - CUZ
1 stop7h 25mLATAM Airlines
Deal found 9/16$278
This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 10/309:25 amCUZ - SCL
1 stop10h 50mSky Airline
jeu. 11/65:50 amSCL - CUZ
1 stop15h 55mSky Airline
Deal found 9/15$279
This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/303:47 pmCUZ - SCL
1 stop11h 14mMultiple Airlines
lun. 10/612:30 pmSCL - CUZ
1 stop9h 25mMultiple Airlines
Deal found 9/15$282
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 10/159:30 amCUZ - SCL
Nonstop3h 20mMultiple Airlines
mer. 10/225:55 amSCL - CUZ
1 stop16h 00mMultiple Airlines
Deal found 9/16$287
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 10/26:25 pmCUZ - SCL
1 stop9h 35mMultiple Airlines
ven. 10/106:35 amSCL - CUZ
1 stop7h 20mMultiple Airlines
Deal found 9/14$288
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/1611:10 pmCUZ - SCL
1 stop16h 25mMultiple Airlines
mar. 9/235:55 amSCL - CUZ
1 stop13h 45mMultiple Airlines
Deal found 9/15$289

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cuzco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septembre 16, 2025.
Use the filters below to find and compare flights from Cusco to Santiago that are best for you.

Fly from

Cuzco

Fly to

Santiago

Route

Depart

Return

Price

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

mer. 10/29

11:02 am-5:14 am

1 stop16h 12m

Santiago Arturo Merino Benitez

mer. 11/5

5:59 am-12:06 pm

1 stop8h 07m

$265

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

mer. 10/29

12:47 pm-5:14 am

1 stop14h 27m

Santiago Arturo Merino Benitez

mar. 11/4

1:35 am-7:45 pm

2 stops20h 10m

$274

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

mer. 10/15

10:40 pm-3:00 pm

1 stop14h 20m

Santiago Arturo Merino Benitez

mer. 10/22

5:55 pm-11:20 pm

1 stop7h 25m

$278

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

jeu. 10/30

9:25 am-10:15 pm

1 stop10h 50m

Santiago Arturo Merino Benitez

jeu. 11/6

5:50 am-7:45 pm

1 stop15h 55m

$279

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

mar. 9/30

4:42 pm-5:01 am

1 stop10h 19m

Santiago Arturo Merino Benitez

dim. 10/5

1:35 am-7:55 pm

2 stops20h 20m

$282

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

mer. 10/15

9:30 am-2:50 pm

Nonstop3h 20m

Santiago Arturo Merino Benitez

mar. 10/21

1:35 am-7:55 pm

2 stops20h 20m

$287

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

jeu. 10/2

6:25 pm-6:00 am

1 stop9h 35m

Santiago Arturo Merino Benitez

ven. 10/10

6:35 am-11:55 am

1 stop7h 20m

$288

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

mar. 10/7

8:40 pm-12:20 pm

2 stops13h 40m

$132

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

dim. 2/15

5:55 pm-2:40 pm

1 stop18h 45m

$133

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

dim. 10/5

10:57 pm-5:01 am

1 stop28h 04m

$138

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 14 results
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Best time to book a flight from Cuzco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Cuzco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cusco to Santiago

How far ahead should I book a flight from Cusco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Cuzco to Santiago. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Cusco to Santiago, you should look to book at least 51 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Cusco to Santiago?

Currently, April is the cheapest month in which you can book a flight from Cusco to Santiago (average of $752). Flying from Cusco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CUZ to SCL?

Find hourly flight availability from Cuzco to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septembre 16, 2025.

When flying from Cusco to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 1% versus a flight in the morning.

How much does it cost to fly round-trip from Cusco to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated septembre 16, 2025.
Read through reviews of airlines operating flights from Cusco to Santiago, such as LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,847 reviews

Boarding

7.6

Crew

8.0

Entertainment

7.0

Overall

7.5

Food

6.7

Comfort

7.4

Reviews

1 / 20
8.0
Excellent

Darrel,Sep 2025

LIM - GRU

The Wi-Fi was not working, so there was no in-flight entertainment. The biggest disappointment was that my Delta diamond status did not transfer any status to my LATAM flight. I WOULD’VE THOUGHT THAT THERE WOULD BE A BETTER WORKING AGREEMENT BETWEEN THE AIRLINES.
LATAM Airlines
7.5
Good
1,847 reviews
LATAM Airlines
7.5
Good
1,847 reviews

Boarding

7.6

Crew

8.0

Entertainment

7.0

Overall

7.5

Food

6.7

Comfort

7.4

Reviews

1 / 20
8.0
Excellent

Darrel,Sep 2025

LIM - GRU

The Wi-Fi was not working, so there was no in-flight entertainment. The biggest disappointment was that my Delta diamond status did not transfer any status to my LATAM flight. I WOULD’VE THOUGHT THAT THERE WOULD BE A BETTER WORKING AGREEMENT BETWEEN THE AIRLINES.

Related info for your journey

Find useful and relevant information for your journey from Cuzco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Cusco to Santiago?

    A quick flight from Cusco to Santiago can take about 14h 20m. JetSMART provides one of the quickest options available for as low as $278. The distance from Cusco to Santiago is about 1373 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Cusco to Santiago round-trip?

    Flying on LATAM Airlines is currently your cheapest option to Santiago, with prices starting at $292. Users have found that LATAM Airlines is 6% cheaper than the other options available to this destination.

  • What are the cheapest flights from Cusco to Santiago?

    While on average a flight from Cusco to Santiago is generally $232, our data shows the cheapest flight currently is $147. When looking at the most popular route, (Cusco Velazco Astete - Santiago Arturo Merino Benitez), you can expect to pay $247 for that flight.

  • Can I find deals for flights from Cuzco to Santiago that include hotel bookings?

    Yes. In addition to deals on Cuzco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cuzco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cuzco to Santiago.

  • Can I find deals for business class flights from Cuzco to Santiago?

    Yes. Cheapflights offers flight deals from Cuzco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cusco to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Cusco to Santiago (average of $752). Flying from Cusco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Cuzco to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Lima to Santiago flights
Arequipa to Santiago flights
Lima to Punta Arenas flights

Top airline flying from Cuzco to Santiago

Discover the top airline that operate flights from Cuzco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septembre 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$292Average$469FlexibilityNo cancel feeOn-time81%

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