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$484+ Cheap flights from Columbus to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/11. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — SCL
Mar 6 — Mar 131
Fri 3/6
Fri 3/13
1 adult, Economy
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Cheap flight deals from Columbus to Santiago

Cheapest flights from Columbus to Santiago
Explore the most affordable flight options available from Columbus to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:45 am
CMH
-
SCL
2 stops27h 54m
Multiple Airlines
Fri 3/2711:24 am
SCL
-
CMH
2 stops23h 17m
Multiple Airlines
Deal found 2/3$676
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:25 am
CMH
-
SCL
2 stops21h 36m
Multiple Airlines
Thu 5/145:01 am
SCL
-
CMH
3 stops41h 12m
Multiple Airlines
Deal found 2/1$709
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:05 pm
CMH
-
SCL
1 stop18h 45m
LATAM Airlines
Tue 8/115:40 am
SCL
-
CMH
2 stops18h 19m
LATAM Airlines
Deal found 2/2$773
This Mytrip deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/65:45 am
CMH
-
SCL
3 stops22h 55m
Multiple Airlines
Fri 3/1311:24 am
SCL
-
CMH
2 stops23h 17m
Multiple Airlines
Deal found 2/4$787
This FlightHub deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:07 am
CMH
-
SCL
1 stop23h 43m
LATAM Airlines
Wed 5/2010:55 pm
SCL
-
CMH
1 stop18h 45m
LATAM Airlines
Deal found 2/1$802

Find flight deals from Columbus to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (C01) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 4, 2026.

Round-trip from

$676
(Mytrip)

One-way from

$484
(American Airlines)

Popular in

December

Cheapest in

June

Average price

$977
From Columbus to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Columbus to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 7% potential increase in price ($78 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in February 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Columbus to Santiago that are best for you.

Fly from

Columbus

Fly to

Santiago

Route

Depart

Return

Price

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Fri 3/20

5:45 am-10:39 am

2 stops27h 54m

Santiago Arturo Merino Benitez

Fri 3/27

11:24 am-9:41 am

2 stops23h 17m

$676

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Mon 5/4

6:25 am-4:01 am

2 stops21h 36m

Santiago Arturo Merino Benitez

Thu 5/14

5:01 am-10:13 pm

3 stops41h 12m

$709

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Fri 3/6

5:45 am-6:40 am

3 stops22h 55m

Santiago Arturo Merino Benitez

Fri 3/13

11:24 am-9:41 am

2 stops23h 17m

$787

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Mon 5/4

12:37 pm-6:50 am

1 stop18h 13m

Santiago Arturo Merino Benitez

Thu 5/14

7:45 am-12:36 am

2 stops16h 51m

$821

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Sun 3/22

6:00 pm-6:45 am

2 stops35h 45m

Santiago Arturo Merino Benitez

Tue 3/24

10:10 pm-12:04 pm

1 stop14h 54m

$878

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Wed 2/11

1:19 pm-8:15 am

1 stop16h 56m

$484

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Wed 2/11

12:19 pm-8:15 am

2 stops17h 56m

$554

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Wed 2/11

6:06 am-5:35 am

3 stops21h 29m

$566

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Best time to book a flight from Columbus to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to Santiago

What is the cheapest month to book a flight from Columbus to Santiago?

Currently, January is the cheapest month in which you can book a flight from Columbus to Santiago (average of $753). Flying from Columbus to Santiago in April is currently the most expensive (average of $1,163). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated February 4, 2026.
See what other customers who have flown with Delta and LATAM Airlines from Columbus to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,145 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,145 reviews
Delta
7.9
Good
8,145 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,918 reviews
Delta
7.9
Good
8,145 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Columbus?

    Located just 8.4 mi from the city center, Santiago Arturo Merino Benitez is the airport most travelers will use when flying to Santiago from Columbus. Booking flights from Columbus to Arturo Merino Benitez (SCL) should be relatively easy as there are 0 daily inbound flights from Columbus from 2 different airlines.

  • What are the cheapest airlines flying from Columbus to Santiago round-trip?

    According to our current data, LATAM Airlines ($748), and Delta ($768) offers the cheapest pricing from Columbus to Santiago. LATAM Airlines is currently priced 26% below the average price you’ll pay for this route.

  • Can I find deals for flights from Columbus to Santiago that include hotel bookings?

    Yes. In addition to deals on Columbus to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Santiago.

  • Can I find deals for business class flights from Columbus to Santiago?

    Yes. Cheapflights offers flight deals from Columbus to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus to Santiago?

    Currently, January is the cheapest month in which you can book a flight from Columbus to Santiago (average of $753). Flying from Columbus to Santiago in April is currently the most expensive (average of $1,163). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Columbus to Santiago

Discover the top 2 airlines that operate flights from Columbus to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$748Average$972FlexibilityNo cancel feeOn-time81%
DeltaCheapest$768Average$909FlexibilityNo cancel feeOn-timeN/A

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